Enzymes, their cellular location, substrates and products in human <a href="https://en.wikipedia.org/wiki/steroidogenesis" class="extiw" title="w:steroidogenesis">steroidogenesis</a>.
<p>Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.
</p><p>White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see <a href="https://en.wikipedia.org/wiki/structural_formula" class="extiw" title="wikipedia:structural formula">Wikipedia:structural formula</a>.
</p><p>HSD: Hydroxysteroid dehydrogenase
</p><p><b>References:</b>
</p>
<ul><li><cite class="book" style="font-style:normal">Boron WF, Boulpaep EL (2003)      <i> Medical Physiology: A Cellular And Molecular Approach</i>, Elsevier/Saunders, pp. page 1,300  <small><a href="https://en.wikipedia.org/wiki/International_Standard_Book_Number" class="extiw" title="en:International Standard Book Number">ISBN</a>:  <a href="//commons.wikimedia.org/wiki/Special:BookSources/1-4160-2328-3" title="Special:BookSources/1-4160-2328-3">1-4160-2328-3</a>. </small></cite></li>
<li>For the absence of conversion of corticosterone to cortisol: <a rel="nofollow" class="external text" href="http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140">Steroid hormone biosynthesis Reference pathway (KO)</a>. <i>KEGG: Kyoto Encyclopedia of Genes and Genomes</i>. Kyoto University Bioinformatics Center. (<span class="mw-formatted-date" title="2013-11-01">1 November 2013</span>).</li></ul><dl><dd>There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.</dd></dl><p><b>Further reading:</b>
</p>
<ul><li><cite style="font-style:normal">Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". <i>The Journal of Steroid Biochemistry and Molecular Biology</i> <b>43</b> (8): 779–804. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/0960-0760(92)90307-5">10.1016/0960-0760(92)90307-5</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/22217824">22217824</a>.</cite></li>
<li><cite style="font-style:normal">Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". <i>Endocrine Reviews</i> <b>25</b> (6): 947–70. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1210/er.2003-0030">10.1210/er.2003-0030</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/15583024">15583024</a>.</cite></li></ul><p><b>See also:</b>
</p>
<ul><li><a href="https://en.wikiversity.org/wiki/Diagram_of_the_pathways_of_human_steroidogenesis" class="extiw" title="wikiversity:Diagram of the pathways of human steroidogenesis">Wikiversity:Diagram of the pathways of human steroidogenesis</a></li></ul>
Translation into Japanese by <a href="//commons.wikimedia.org/wiki/User:%E3%81%AB%E3%82%87%E3%82%8D%E3%82%93" title="User:にょろん">User:にょろん</a> based on the version by David Richfield (<a href="//commons.wikimedia.org/wiki/User:Slashme" title="User:Slashme">User:Slashme</a>) and <a href="//commons.wikimedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m" title="User:Mikael Häggström">Mikael Häggström</a>. Derived from previous version by <a href="//commons.wikimedia.org/wiki/User:Hoffmeier" title="User:Hoffmeier">Hoffmeier</a> and <a href="https://en.wikipedia.org/wiki/User:Settersr" class="extiw" title="wikipedia:User:Settersr">Settersr</a>.
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<a class="external free" href="https://upload.wikimedia.org/wikipedia/commons/1/13/Steroidogenesis.svg">https://upload.wikimedia.org/wikipedia/commons/1/13/Steroidogenesis.svg</a> (Original SVG file as of 2013/3/13(wed) 15:12), <cite style="font-style:normal">Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". <i>WikiJournal of Medicine</i> <b>1</b> (1). <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.15347/wjm/2014.005">10.15347/wjm/2014.005</a>. <a href="https://en.wikipedia.org/wiki/International_Standard_Serial_Number" class="extiw" title="en:International Standard Serial Number">ISSN</a> <a rel="nofollow" class="external text" href="https://www.worldcat.org/issn/20024436">20024436</a>.</cite>