Dizopiramid
Dizopiramid (INN, -{Norpace, Rythmodan}-) antiaritmički je lek, koji se koristi za tretiranje ventrikularne tahikardije. On je blokator natrijumovog kanala i stoga se klasifikuje u klasu 1a anti-aritmičkih agenasa. Dizopiramid ima negativno inotropno dejstvo na ventrikularni miokard. On znatno umanjuje kontraktilnost. Dizopiramid takođe ima antiholinergički uticaj na srce, što uzrokuje mnoštvo nuspojava. Dizopiramid je dostupan u oralnoj i intravenoznoj formi, i ima nizak stepen toksičnosti.

Hemija 
Dizopiramid se može sintetisati iz benzil cijanida i 2-bromopiridina:

Reference

Literatura 
 -{
 Guyton, Arthur C., Hall, John E. (2006). Textbook of Medical Physiology (11th ed.). Philadelphia: Elsevier Saunders.
 Rizos, I. I., et al. "Effects of Intravenous Disopyramide and Quinidine on Normal Myocardium and on the Characteristics of Arrhythmias: Intraindividual Comparison in Patients with Sustained Ventricular Tachycardia." European heart journal 8.2 (1987): 154-63. Biological Sciences. Web. 10 Feb. 2012.
 Katzung, Bertram G., Masters, Susan B., Trevor, Anthony J. (2009). Basic and Clinical Pharmacology (11th ed.). New York: McGraw Hill
 Levites, R. R., and G. J. GJ Anderson. "Electrophysiological Effects of Disopyramide Phosphate during Experimental Myocardial Ischemia." American Heart Journal 98.3 (1979): 339-44. Biological Sciences. Web. 15 Feb. 2012.
 Hulting J, Rosenhamer G: Hemodynamic and electrocardiographic effects of disopyramide in patients with ventricular arrhythmia. Acta Med Scand 199:41-51, 1976.
 Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012.
 Kim, S. Y. SY, and N. L. NL Benowitz. "Poisoning due to Class IA Antiarrhythmic Drugs. Quinidine, Procainamide and Disopyramide." Drug safety : an international journal of medical toxicology and drug experience 5.6 (1990): 393-420. Biological Sciences; Environmental Science and Pollution Management. Web. 12 Feb. 2012.
}-

Spoljašnje veze 

-{Disopyramide on RxList}-

Пиридини
Блокатори натријумовог канала
Амиди
Dizopiramid ( INN , -{ Norpace , Rythmodan }- ) antiaritmički je lek , koji se koristi za tretiranje ventrikularne tahikardije . On je blokator natrijumovog kanala i stoga se klasifikuje u klasu anti-aritmičkih agenasa . Dizopiramid ima negativno inotropno dejstvo na ventrikularni miokard . On znatno umanjuje kontraktilnost . Dizopiramid takođe ima antiholinergički uticaj na srce , što uzrokuje mnoštvo nuspojava . Dizopiramid je dostupan u oralnoj i intravenoznoj formi , i ima nizak stepen toksičnosti . Hemija Dizopiramid se može sintetisati iz benzil cijanida ibromopiridina : Reference Literatura - { Guyton , Arthur C . , Hall , John E . Textbook of Medical Physiologyh ed . ) . Philadelphia : Elsevier Saunders . Rizos , I. I . , et al . " Effects of Intravenous Disopyramide and Quinidine on Normal Myocardium and on the Characteristics of Arrhythmias : Intraindividual Comparison in Patients with Sustained Ventricular Tachycardia . " European heart journal2 Biological Sciences. Web.Feb . Katzung , Bertram G . , Masters , Susan B . , Trevor , Anthony J. Basic and Clinical Pharmacologyh ed . ) . New York : McGraw Hill Levites , R. R . , and G. J. GJ Anderson . " Electrophysiological Effects of Disopyramide Phosphate during Experimental Myocardial Ischemia . " American Heart Journal3 Biological Sciences. Web.Feb . Hulting J , Rosenhamer G : Hemodynamic and electrocardiographic effects of disopyramide in patients with ventricular arrhythmia . Acta Med Scand41-51 , Mathur , P. P. PP . " Cardiovascular Effects of a Newer Antiarrhythmic Agent , Disopyramide Phosphate . " American Heart Journal6 Biological Sciences ; Environmental Science and Pollution Management. Web.Feb . Kim , S. Y. SY , and N. L . NL Benowitz . " Poisoning due to Class IA Antiarrhythmic Drugs . Quinidine , Procainamide and Disopyramide . " Drug safety \ : an international journal of medical toxicology and drug experience6 Biological Sciences ; Environmental Science and Pollution Management. Web.Feb . }- Spoljašnje veze -{ Disopyramide on RxList }- Пиридини Блокатори натријумовог канала Амиди