define hox gene
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- Hox gene. n. Any of a group of homeobox genes that exist as clusters in animals, especially in vertebrates, and determine the identity and locations of body parts along the anterior-posterior body axis in a developing fetus or larva. [From h(omeob)ox 1  .]. Facebook.
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- What is HoFH? HoFH is an inherited disorder of lipoprotein metabolism characterized by marked elevation of low density lipoprotein cholesterol (LDL-C), xanthomata and premature cardiovascular disease. In most cases the underlying genetic abnormality is mutation of both alleles of the LDL-receptor (LDLR) gene.
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- Similar to ASPM, however, these results were not replicated in other samples, and in the Dutch Adults sample, VIQ was significantly associated with the A-allele, rather than the D-allele, of Microcephalin in the family-based test of additive and dominant effects (P = 0.03).ecent advances in comparative genomics and population genetics have facilitated rapid progress in studying the genetic basis of human brain evolution. By searching for signatures of adaptive evolution in genes known to function in the mammalian brain, a large number of candidate loci have been identified (2).
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Science Chapter 14 Sections. Sex-linked disorders are caused by alleles of genes usually carried on the X chromosome. Sex chromosome disorders are caused by nondisjunction, or sex chromosomes failing to separate correctly during meiosis. What is the Human Genome Project? An ongoing effort to analyze the human DNA sequence
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Developmental biology: Hox gene variation and evolution Figure 1: Evolutionary conservation of the Hox gene clusters in zebrafish, pufferfish, mouse and Amphioxus. The zebrafish Hox gene clusters are shown with the 34 genes confirmed by Prince et al. , and an additional eight, for the total of 42 that the zebrafish is likely to have.
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HOTAIR For other uses, see Hot air. HOTAIR (for HOX transcript antisense RNA) is a human gene located on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence transcription on another chromosome.
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Hox gene Similarly, mutations in the Hox genes can result in body parts and limbs in the wrong place along the body. Like a play director, the Hox genes do not act in the play or participate in limb formation themselves. The protein product of each Hox gene is a transcription factor. Each Hox gene contains a well-conserved DNA sequence known as the homeobox. Hox genes are thus a subset of the homeobox transcription factor genes. In many animals, the organization of the Hox genes in the chromosome is the same as the order of their expression along the anterior-posterior axis of the developing animal, and are thus said to display colinearity.
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Chapter 15 Sex linked gene. gene located on the X or Y chromosome. fathers can pass sex-linked alleles to all of their daughters but to none of their sons, mothers can pass to both sons and daughters. iN humans sex-linked gene refers to a gene on the X chromosome.
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APTXGene  (Protein Coding) APTX (Aprataxin) is a Protein Coding gene. Diseases associated with APTX include Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia and Aptx-Related Coenzyme Q10 Deficiency. Among its related pathways are DNA Damage.
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What mechanism generates our fingers and toes? Genetic studies confirm a mathematical model By studying the role of Hox genes during limb development, we were able to show, for the first time, that the patterning process that generates our fingers and toes relies on a Turing-like mechanism..
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- The growth arrest homeobox gene hereinafter referred to as the Gax gene and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.
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Fragile X syndrome Location of FMR1 gene on the X chromosome. Fragile X syndrome is a genetic disorder which occurs as a result of a mutation of the fragile X mental retardation 1 (FMR1) gene on the X chromosome, most commonly an increase in the number of CGG trinucleotide repeats in the 5' untranslated region of FMR1.
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- Publications for APTX Gene. 1  Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. (PMID: 11586299) Date H. … Tsuji S. (Nat. 2  The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn- finger protein aprataxin. (PMID: 11586300) Moreira M.-C.
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Raccoon poxvirus as a gene expression and vaccine vector for genes of rabies virus and other organisms The invention is a recombinant raccoon poxvirus. Such recombinant viruses can be used for the production of oral or injectable vaccines for wildlife, livestock, or companion animals to control rabies and for the production of related biochemical and immunobiological reagents.or the purpose of this invention, the following definitions are provided. A late promoter is defined as a DNA segment that includes nucleotide sequences that. regulate gene expression and are functionally active after, but not before, the replication of virus DNA in infected cells.
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Developmental biology: Hox gene variation and evolution Surprisingly, they found that the zebrafish has three Hox genes (Hox C3, Hox A8 and Hox B10), with no direct mouse equivalents (Fig. 1). Moreover, the expression domains of the anterior Hox genes are partly overlapping, and restricted to a shorter anterior region.
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- Hereditary disorder caused by a mutant allele of a single gene (e.g., Duchenne muscular dystrophy, retinoblastoma, sickle cell disease).Definition from: Human Genome Project Information at the U.S. Department of Energy.ereditary disorder caused by a mutant allele of a single gene (e.g., Duchenne muscular dystrophy, retinoblastoma, sickle cell disease).
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Homeoboxes Because homeobox genes have so many important functions, mutations in these genes are responsible for a variety of developmental disorders. For example, mutations in the HOX group of homeobox genes typically cause limb malformations.Changes in PAX homeobox genes often result in eye disorders, and changes in MSX homeobox genes cause abnormal head, face, and tooth development.ecause homeobox genes have so many important functions, mutations in these genes are responsible for a variety of developmental disorders. For example, mutations in the HOX group of homeobox genes typically cause limb malformations.
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- An origin of gene conversion. (a) Heteroduplexes formed by the resolution of Holliday structure or by other mechanisms. (b) The blue DNA uses the invaded segment (e') as template to correct the mismatch, resulting in gene conversion.
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Chromosome Ph1 chromosome (Philadelphia chromosome) an abnormality of chromosome 22, characterized by the translocation of genetic material from its long arm to chromosome 9, seen in the marrow cells of most patients with chronic myelogenous leukemia.
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Biology Chapter 10 Patterns of Inheritance referring to a pattern of inheritance characteristic of genes located on one type of sex chromosome (for example X) and not found on the other type (for example Y); in mammals, in almost all cases, the gene controlling the trait is on the X chromosome so this pattern is often called X-linked.
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- All seven sub-families of opsin were already present in the last common ancestor of animals. In addition, the genetic toolkit for positioning eyes is common to all animals: the PAX6 gene controls where the eye develops in organisms ranging from octopuses to mice to fruit flies.
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- EPH. A gene on chromosome 7q32-q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. gene on chromosome 7q32-q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells.
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Hox gene The products of Hox genes are Hox proteins. Hox proteins are transcription factors, which are proteins that are capable of binding to specific nucleotide sequences on the DNA called enhancers where they either activate or repress genes. The same Hox protein can act as a repressor at one gene and an activator at another.
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Bcl-2-associated X protein The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis. The p53 protein is a transcription factor that, when activated as part of the cell's response to stress, regulates many downstream target genes, including BAX.he BAX gene was the first identified pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero-or homodimers.
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- Hox gene is an example of a homeobox gene. The homeobox sequence codes for a 60 amino acid protein domain known as the homeodomain. The main role of homeodomain is to act as a switch that controls gene transcription. See also: Hox gene.Please contribute to this project, if you have more information about this term feel free to edit this page.This page was last modified on 12 January 2009, at 09:04.This page has been accessed 11,228 times.he main role of homeodomain is to act as a switch that controls gene transcription. See also: Hox gene. Please contribute to this project, if you have more information about this term feel free to edit this page. This page was last modified on 12 January 2009, at 09:04.This page has been accessed 11,228 times.
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- Overexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with cancer cell proliferation, invasion, progression, and metastasis as well as poor survival in a variety of human cancers including breast cancer (BC).