what do waldenstrom's macroglobulinemia
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Overview Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. If you have Waldenstrom macroglobulinemia, your bone marrow produces too many abnormal white blood cells that crowd out healthy blood cells. The abnormal white blood cells produce a protein that accumulates in the blood, impairs circulation and causes complications. Waldenstrom macroglobulinemia is considered a type of non-Hodgkin's lymphoma. It's sometimes called lymphoplasmacytic lymphoma.
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Lipopolysaccharide Lipopolysaccharides, also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. The term lipooligosaccharide is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides.
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- Multiple myeloma is a blood cancer that develops in the bone marrow (Figure 1). In myeloma, normal antibody-producing plasma cells transform into malignant myeloma cells. Myeloma cells produce large quantities of one antibody (or immu-noglobulin) called monoclonal (M) pro-tein.
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Goodpasture syndrome Goodpasture syndrome (GPS; also known as Goodpasture’s disease, antiglomerular basement antibody disease, or anti-GBM disease) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.oodpasture syndrome (GPS; also known as Goodpasture’s disease, antiglomerular basement antibody disease, or anti-GBM disease) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.
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- Myelophthisic anemia. Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases that affect the bone marrow. Myelophthisis refers to the displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.
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Hyperinsulinemia Hyperinsulinemia, or hyperinsulinaemia is a condition in which there are excess levels of insulin circulating in the blood than expected relative to the level of glucose.While it is often mistaken for diabetes or hyperglycaemia, hyperinsulinemia can result from a variety of metabolic diseases and conditions.ollowing birth, the hyperglycemic maternal blood is no longer accessible to the neonate resulting in a rapid drop in the newborn’s blood glucose levels. As insulin levels are still elevated this results in hyperinsulinemia.
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- Paraproteinemia is the presence of paraproteins or monoclonal gammaglobulins in the blood. It's common in people with leukemia and...
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- 1 Both blood and urine beta 2 microglobulin (B2M) tests may be ordered along with other kidney function tests to evaluate kidney damage and disease and to distinguish between disorders that affect the glomeruli and the renal tubules.
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The Alphabet Soup of Diabetes - What Do All of Those Acronyms Mean? For people with diabetes, especially those with protein in their urine, it also helps slow down kidney damage. Arteriosclerosis: (ar-TEER-ee-oh-skluh-RO-sis): hardening of the arteries. BG - Blood glucose (the measurement of glucose circulating in the blood); also known as BS (blood sugar). BMI: Body mass index.
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gamma globulin gamma globulin. 1. a class of plasma proteins composed almost entirely of immunoglobulins, the proteins that function as antibodies. Production of gamma globulin may be increased in the body when there is invasion by harmful microorganisms. An abnormal amount in the blood, a condition known as hypergammaglobulinemia, may be indicative of a chronic infection or certain malignant blood diseases.
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Anemia, Megaloblastic Megaloblastic anemia is a condition in which the bone marrow produces unusually large, structurally abnormal, immature red blood cells (megaloblasts). Bone marrow, the soft spongy material found inside certain bones, produces the main blood cells of the body-red cells, white cells, and platelets.Anemia is a condition characterized by the low levels of circulating, red blood cells.ernicious anemia is a rare blood disorder characterized by the inability of the body to properly utilize vitamin B12, which is essential for the development of red blood cells. Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed.
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- Pelger–Huet huët (anomaly: [pronunciation′pel gər′hyo̅o̅]) ət is a blood laminopathy associated with the Lamin b. receptordentifying Pelger–Huet huët anomaly is important to differentiate from bandemia with a-left shifted peripheral blood smear and neutrophilic band forms and from an increase in young neutrophilic forms that can be observed in association with. infection
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Monoclonal Gammopathies Monoclonal gammopathies are conditions in which abnormal proteins are found in the blood. These proteins develop from a small number of plasma cells in the bone marrow. Plasma cells make up just 1 percent of bone marrow cells. Their main function is to fight off infection. The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance (MGUS). It is not cancer. But people with MGUS have an increased risk of developing serious diseases of the bone marrow and blood.
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- Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.utations in the HBB gene cause sickle cell disease. Hemoglobin consists of four protein subunits, typically, two subunits called alpha-globin and two subunits called beta-globin. The HBB gene provides instructions for making beta-globin.
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Alone we are rare. Together we are strong.â¥ Donate Today Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
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What is Paraproteinemia? The third type involves whole immunoglobulins, wherein there is an abnormal ratio of light chains to heavy chains. In general, when monoclonal gammopathy involves heavy chains or whole immunoglobulins, the paraproteins are retained within the blood vessels. Sometimes, whole immunoglobulins aggregate and form polymers, leading to a condition called macroglobulinemia.
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Hypergammaglobulinemia Hypergammaglobulinemia is a condition that is characterized by the increased levels of a certain immunoglobulin in the blood serum. The name of the disorder refers to an excess of proteins after serum protein electrophoresis (found in the gammaglobulin region). Most hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM), because this is the default immunoglobulin type prior to class switching.
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Alpha Thalassemia *Alpha thalassemia facts medical author: Melissa Conrad Stöppler, MD. Alpha thalassemia is a blood disorder that reduces the production of normal hemoglobin, the protein in red blood cells that carries oxygen to cells throughout the body. There are four types of alpha thalassemia, hemoglobin Bart hydrops fetalis syndrome or Hb Bart syndrome (the more severe form), HbH disease, silent carrier state and trait. Alpha thalassemia occurs frequently in people from Mediterranean countries, North Africa, the Middle East, India, and Central Asia.
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WaldenstrÃ¶m's Macroglobulinemia Waldenström's Macroglobulinemia. Important. It is possible that the main title of the report Waldenström's Macroglobulinemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
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- Both blood and urine beta 2 microglobulin (B2M) tests may be ordered along with other kidney function tests to evaluate kidney damage and disease and to distinguish between disorders that affect the glomeruli and the renal tubules.
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Immunofixation - Blood Back to Top Why the Test Is Performed. This test is most often used to check the levels of certain antibodies associated with multiple myeloma and Waldenstrom's macroglobulinemia .Those antibodies include IgG, IgM, IgA, lambda light chain forms, and kappa light chain forms.here is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
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- This test is ordered when a person has symptoms of an immunoglobulin deficiency such as recurrent infections, especially of the respiratory tract (sinus, lungs) or gastrointestinal tract (stomach, intestines), and/or chronic diarrhea.mmunoglobulins testing may also be ordered when a person has signs of chronic inflammation or chronic infection and when a health practitioner suspects excess or abnormal immunoglobulin production. The test may be ordered periodically to monitor the course of a person's condition.
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Beta thalassemia Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body.Affected individuals also have a shortage of red blood cells (anemia), which can cause pale skin, weakness, fatigue, and more serious complications.ithout sufficient hemoglobin, red blood cells do not develop normally, causing a shortage of mature red blood cells. The low number of mature red blood cells leads to anemia and other associated health problems in people with beta thalassemia.
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Beta-2 Microglobulin Tumor Marker This beta-2 microglobulin (B2M) test is used as a tumor marker for some blood cell cancers. It is not diagnostic for a specific disease, but it has been associated with the amount of cancer present (tumor burden) and can give the health practitioner additional information about someone's likely prognosis.
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hypergammaglobulinemia An increased amount of the γ-globulins in the plasma, such as that frequently observed in chronic infectious diseases. hypergammaglobulinemia. monoclonal hypergammaglobulinemias plasma cell dyscrasias. hypergammaglobulinemia. n. An increased concentration of gamma globulins in plasma, as in chronic infectious diseases.
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What is plasmacytoma? They play an important role in protecting the body against infection and disease by producing proteins called immunoglobulins (Ig), also known as antibodies. There are two main types of solitary plasmacytomas: Solitary bone plasmacytoma (SBP) - where there is localised build-up of abnormal plasma cells in the bone.