what does homocysteine level mean
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homocysteine The level of homocysteine in the blood can be measured with a simple blood test that is often, but not always, done after fasting. Homocysteine levels of 12 mmol/L are considered normal and levels below 10 mmol/L are considered desirable.
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Hyperhomocysteinemia As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of vitamin B6, folic acid (vitamin B 9), and vitamin B12 can lead to high homocysteine levels. Hyperhomocysteinemia is typically managed with vitamin B6, vitamin B9 and vitamin B12 supplementation.
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- Useful For. Direct mutation analysis for the MTHFR C677T mutation should be reserved for patients with coronary artery disease, acute myocardial infarction, peripheral vascular artery disease, stroke, or venous thromboembolism who have increased basal homocysteine levels or an abnormal methionine-load test.seful For. Direct mutation analysis for the MTHFR C677T mutation should be reserved for patients with coronary artery disease, acute myocardial infarction, peripheral vascular artery disease, stroke, or venous thromboembolism who have increased basal homocysteine levels or an abnormal methionine-load test.
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10 Health Tips for Anyone with a MTHFR Gene Mutationâ¦ I have the MTHFR gene mutation C677T. It is heterozygous. My homocysteine levels are normal. I had my folic acid and B12 levels also tested and they also came back normal (folic acid was 46 pmol/L – normal values according to lab range from 7 to 36; B12 was 416 pmol/L – normal values are 156-672). If you test positive, read on, if you test negative, stick to recommended dose of 800 micrograms of folic acid per day. 2  If you tested positive for MTHFR gene polymorphism you will need follow the treatment for MTHFR mutation: start taking 1-5 mg of folic acid a day. 3  Methylated form is best (5-MTHF).
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- November 22 2015 by Ray Sahelian, M.D. Homocysteine is a derivative of the amino acid methionine. It received a great deal of media attention in 1997 following publication of articles in medical journals indicating that a high homocysteine blood level is a potential risk factor for stroke and heart disease.
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- A homocysteine blood test is done to: 1  Help identify vitamin B12 deficiency or folic acid deficiency. 2  But other tests for these deficiencies are available.3  Help identify a rare inherited disease (homocystinuria) that causes a deficiency of one of several enzymes needed to convert food to energy. homocysteine blood test is done to: 1  Help identify vitamin B12 deficiency or folic acid deficiency. 2  But other tests for these deficiencies are available.
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Useful For The most sensitive test for vitamin B12 deficiency at the cellular level is the assay for MMA. If clinical symptoms suggest deficiency, measurement of MMA and homocysteine should be considered, even if serum vitamin B12 concentrations are normal.or specimens without antibodies, follow-up testing of vitamin B12 tissue deficiency by measuring methylmalonic acid (MMA) (MMAS / Methylmalonic Acid [MMA], Quantitative, Serum) and/or homocysteine (HCYSP / Homocysteine, Total, Plasma) may be indicated if the patient is symptomatic.
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- Homocysteine: An amino acid that is produced by the human body, usually as a byproduct of consuming meat. Homocysteine is normally converted into other amino acids. An abnormal accumulation of homocysteine, which can be measured in the blood, can be a marker for the development of heart disease.
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- Fortunately, homocysteine can also be converted into cysteine by the B vitamins, folate, B12 and B6. When an individual consumes large amounts of foods rich in these B vitamins, not only will homocysteine levels go down, but hydrogen sulfide levels can go up since the body uses cysteine to make hydrogen sulfide.he B vitamins folate, B6, and B12 are necessary cofactors in an essential cellular process called the methylation cycle. In this cycle, all three B vitamins are used to convert a potentially damaging molecule called homocysteine into the useful amino acid cysteine.
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- Furthermore, a MTHFR C677T mutation may cause elevated levels of homocysteine in the body. Homocysteine contributes to oxidative stress and increases risk of heart disease when elevated. MTHFR A1298C MTHFR A1298C mutations affect conversion of methylfolate into BH4, or tetrahydrobiopterin.omozygous mutations are more severe than heterozygous mutations and often require additional treatment. If you see a +/+ for any mutation, this means you are homozygous for that mutation. If you see +/- for a mutation, this means you are heterozygous for that mutation. A -/- means you do not have that mutation.
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- Some of the excess homocysteine is excreted in urine. Rarely, homocystinuria can be caused by mutations in several other genes. The enzymes made by the MTHFR, MTR, MTRR, and MMADHC genes play roles in converting homocysteine to methionine. Mutations in any of these genes prevent the enzymes from functioning properly, which leads to a buildup of homocysteine in the body.
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- To learn what the results mean for you, talk with your health care provider. The normal range of homocysteine levels for people up to age 30 is 4.6 to 8.1 micromoles per liter (mcmol/L). Between ages 30 and 59, normal ranges are 6.3 to 11.2 mcmol/L for men and 4.5 to 7.9 mcmol/L for women.
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MTHFR Mutation If a person has two copies (homozygous) of MTHFR C677T, or has one copy of C677T and one of A1298C, then it is likely that elevated homocysteine levels are due to these inherited mutations, or that the mutations are contributing to them.f a person has two copies (homozygous) of MTHFR C677T, or has one copy of C677T and one of A1298C, then it is likely that elevated homocysteine levels are due to these inherited mutations, or that the mutations are contributing to them.
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- In folate deficiency, homocysteine levels are elevated and MMA levels are normal. In vitamin B12 deficiency, the analytic variability (CV) of both serum and RBC folate assays is considerable. Homocysteine and MMA levels are alternate determinates of folate deficiency.
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- Betaine ( trimethylglycine ) ( 6 grams per day ) and choline ( 2 grams per day ) have each been shown to lower homocysteine levels.5 , 6 Choline in the amount of 2.6 grams per day ( provided as 34 grams per day of soy lecithin ) has also been shown to lower homocysteine levels in a double-blind trial.7 More recently , 1.5 grams of betaine per day , ...
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What is an MTHFR Mutation? Individuals with low activity of the MTHFR enzyme may present with elevated homocysteine levels, which have been associated with inflammation and heart disease, birth defects, difficult pregnancies, and potentially an impaired ability to detoxify.
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MTHFR Mutation The MTHFR mutation test may sometimes be ordered when a person has elevated homocysteine levels, especially when the person has a personal or family history of premature cardiovascular disease or thrombosis.
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Methionine Elevated Homocysteine Levels. High homocysteine levels have been associated with increase thrombosis (blood clots in the veins) and cardiovascular disease (atherosclerosis). It is considered corrosive to the collagen and elastin in our bodies.levated Homocysteine Levels. High homocysteine levels have been associated with increase thrombosis (blood clots in the veins) and cardiovascular disease (atherosclerosis). It is considered corrosive to the collagen and elastin in our bodies.
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MTHFR C677T Mutation Basics Folate found naturally in foods, such as leafy green vegetables, does not pose a problem.The MTHFR C677T mutation may also cause high homocysteine levels, as methylfolate plays an important role in homocysteine metabolism.Elevated homocysteine levels can cause oxidative stress and increase your risk of heart disease.olate found naturally in foods, such as leafy green vegetables, does not pose a problem.The MTHFR C677T mutation may also cause high homocysteine levels, as methylfolate plays an important role in homocysteine metabolism.
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- Homocysteine: An amino acid that is normally present in blood. Homocystinuria: A severe form of hyperhomocysteinemia. Hypercoagulable state: A condition in which a person has an increased tendency to form blood clots. Also called thrombophilia. Hyperhomocysteinemia: A form of acquired thrombophilia resulting from a high level of homocysteine in the blood. Hypothyroidism: A medical condition caused by deficient thyroid activity.
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MTHFR Mutation When a person has two copies of the MTHFR C677T gene mutation (homozygous) or one copy of MTHFR C677T and one copy of A1298C (compound heterozygous), decreased MTHFR enzyme activity slows down the homocysteine-to-methionine conversion process and can lead to a buildup of homocysteine in the blood.
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- He also had high homocysteine level, due to his MTHFR gene mutation (he is homozygous C677t) and this is now corrected on methyl B12 and FolaPro (5-methyltetrahydrofolate) . ...He takes a high potency B....
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Andrew's Nutritional Health Resources The higher these levels the greater your risk of having a heart attack or stroke. Most labs report a normal homocysteine should be in the range of 5 to 12 or even 15 micromols/L. If your homocysteine level is above 12 micromols/L, you are in serious trouble.
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Vitamin B12Deficiency Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.