methotrexate definition
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Definitions &Translations Freebase(0.00 / 0 votes)Rate this definition: Methotrexate. Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid.
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Drug-Induced Liver Disease Methotrexate (Rheumatrex, Trexall) has been used for the long-term treatment of patients with severe psoriasis, rheumatoid arthritis, psoriatic arthritis, and some patients with Crohn's disease. Methotrexate has been found to be a cause of liver cirrhosis in a dose-dependent fashion.
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Methotrexate for Ectopic Pregnancy Methotrexate can be used to: 1  End an early ectopic pregnancy. 2  Prevent the growth of any embryonic or fetal cells that are left behind after surgery to end an ectopic pregnancy.
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Methotrexate: Managing Side Effects Most patients who use methotrexate to treat their inflammatory arthritis take between 10 and 25 milligrams (mg) per week. By contrast, the doses used to treat leukemia and certain other types of cancer may be hundreds of times larger.
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Rheumatrex Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types.
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Rheumatoid Arthritis  In-Depth Report Methotrexate (Rheumatrex™) 1  Originally developed as a chemotherapy drug (to treat cancer) and used as an immunosuppressant (to treat lupus). 2  Known as the gold standard -- the best drug -- for the treatment of rheumatoid arthritis. 3  Shown to be very effective in treating skin lesions, arthritis and pleuritis in people with lupus.
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Trexall Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis. Methotrexate is usually given after other medications have been tried without successful treatment of symptoms. Methotrexate may also be used for other purposes not listed in this medication guide.
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- METHOTREXATE is a chemotherapy drug. This medicine affects cells that are rapidly growing, such as cancer cells and cells in your mouth and stomach. It is used to treat many cancers and other medical conditions.
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Methotrexate for injection Rx Indications for Methotrexate for injection: Non-metastatic osteosarcoma in patients who have undergone surgical resection or amputation for the primary tumor (high-dose therapy with leucovorin rescue).
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methotrexate sodium (PF) injection Otrexup (PF) subcutaneous. Methotrexate has rarely caused serious (sometimes fatal) side effects. Therefore, this medication should be used only to treat severe diseases caused by an overactive immune system (such as psoriasis, rheumatoid arthritis). Methotrexate has caused birth defects and death in unborn babies.
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Systemic Medications: Methotrexate Systemic Medications: Methotrexate Approved by the FDA in the 1970s for treatment of severe psoriasis, methotrexate was initially used to treat cancer. In a person with psoriasis, methotrexate binds to and inhibits an enzyme involved in the rapid growth of skin cells and slows down their growth rate.
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- methotrexate. METHOTREXATE is a chemotherapy drug. This medicine affects cells that are rapidly growing, such as cancer cells and cells in your mouth and stomach. It is used to treat many cancers and other medical conditions.
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methotrexate - oral WARNING: Methotrexate has infrequently caused serious (sometimes fatal) side effects. Therefore, this medication should be used only to treat cancer or severe diseases caused by an overactive immune system (such as psoriasis, rheumatoid arthritis).ethotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis). (See also Side Effects section.).
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- Methotrexate may cause severe and sometimes fatal side effects. These may include infection or stomach, bowel, bone marrow, blood, liver, immune system, nerve, lung, kidney, or skin problems. For this reason, methotrexate is only used to treat certain patients who have severe psoriasis or rheumatoid arthritis that is not relieved by other treatments.
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methotrexate methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis. amethopterin, methotrexate sodium. antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite.
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Methotrexate: Managing Side Effects Understand the side effects of methotrexate and how you can take measures to keep them to a minimum. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis.
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Methotrexate How Methotrexate Is Given: 1  As an infusion into the vein (intravenous, IV). 2  As an injection into the muscle (intramuscular, IM). 3  Another method is by intraventricular or intrathecal infusion.  There is also a pill form of methotrexate to be taken by mouth.
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How long does tramadol withdrawal last? Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests. Coupons and discounts. (24) 2.5mg tablet. Cost for (24) 2.5mg tablets of Otrexup (Methotrexate) at pharmacies.
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What is methotrexate? Methotrexate is available as 2.5mg and 10mg tablets, and as a solution for injection. Most people are prescribed tablets. The most common dose is 15 mg each week, but it varies from 2.5 mg to 30 mg each week depending on kidney function, side effects experienced, and efficacy in treating the skin disease.
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Methotrexate â what do patients need to know, and when? Our new research aims to improve the way patients find out the facts about methotrexate, an important but much-maligned medication. Despite the advent of biological drugs for rheumatoid and other forms of inflammatory arthritis over the past decade, the drug that remains the mainstay of treatment for the vast majority of patients is methotrexate.
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- Methotrexate has an unusual history. What began as a drug for the treatment of cancer, particularly childhood leukemia, is now used to treat a wide variety of immunologic disorders. 1 The use of methotrexate in the treatment of psoriasis and rheumatoid arthritis dates from the 1960s.he dose packs consist of four cards with two, three, four, five or six 2.5-mg tablets. The cost for a weekly dose (7.5 to 15.0 mg) of methotrexate tablets ranges from $6 to $15 for the generic product and from $9 to $22 for Rheumatrex.
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Methotrexate Although originally designed as a chemotherapy drug (using high doses), in low doses, methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases. Because of its effectiveness, low-dose methotrexate is now first-line therapy for the treatment of rheumatoid arthritis.
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Methotrexate and Pregnancy Methotrexate (Rheumatrex®, Trexall®) is a prescription medication that should be avoided by almost all pregnant women, except in a few circumstances, such as to treat an ectopic pregnancy. This drug can cause miscarriages, birth defects, and other serious problems.
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Trexall Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have: alcoholism, cirrhosis, or other liver disease; a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells); a bone marrow disorder; or. if you are breast-feeding a baby.