what is interleukin
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- Noun. 1. interleukin-any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system. lymphokine-a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages).
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Interleukin Interleukin 13 (IL-13) is a pleiotropic cytokine that may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis.
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Interferon What are interferons and how do they work? Interferons are a family of naturally-occurring proteins that are made and secreted by cells of the immune system (for example, white blood cells, natural killer cells, fibroblasts, and epithelial cells). Three classes of interferons have been identified: alpha,
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interleukin-1 in·ter·leu·kin-·1. A cytokine, derived primarily from mononuclear phagocytes, that enhances the proliferation of T-helper cells and the growth and differentiation of B cells. Il-1 induces the release of Il-2. When secreted in larger quantities, IL-1 is a mediator of inflammation, entering the bloodstream and causing fever, inducing synthesis of acute phase proteins, and initiating metabolic wasting.
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Interleukin-1 receptor family Interleukin-1 receptor family. Members of the very wide interleukin-1 receptor (IL-1R) family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1R (TIR) domain. It is a group of structurally homologous proteins, conserved throughout the species as it was identified from plants to mammals.
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- Interferons are proteins that have antiviral, antiproliferative, and immunomodulatory effects. Published reports indicate that after IFN-a treatment with 5 million U/day or 10 million U 3 times per week subcutaneously (SC) for 4 months, HBV DNA levels and HBeAg become undetectable in 30-40% of patients.
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- Home / Human Interferon Alpha ELISA Plasma Matrix Study Abstract Accurate detection of Interferons (IFN) in serum or plasma samples by Enzyme-Linked Immunosorbent Assay (ELISA) is affected by interference from components in serum or plasma such as heterophilic antibodies and clotting factors.
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- Summary. The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15.
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- Interferon-beta (fibroblast interferon) is produced by virus-infected fibroblasts, or virus-infected epithelial cells, etc. Interferon-a (a family of about 20 related proteins) and interferon-b are particularly potent as antiviral agents. They are not expressed in normal cells, but viral infection of a cell causes interferons to be made and released from the cell (that cell will often eventually die as a result of the infection).
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What are Cytokines? In addition, cytokines have a much larger distribution of sources for their production, with nearly all cells that have a nucleus capable of producing interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α), particularly endothelial cells, epithelial cells and resident macrophages.
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Interleukin Interleukin 3 (IL3) is a cytokine that regulates blood-cell production by controlling the production, differentiation and function of granulocytes and macrophages.
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cytokine cytokine. [sī′təkīn]. one of a large group of low-molecular-weight proteins secreted by various cell types and involved in cell-to-cell communication, coordinating antibody and T cell immune interactions, and amplifying immune reactivity.ytokine. any of many small, secreted proteins such as erythropoietin, G-CSF, interferon, interleukins, that bind to cell surface receptors and transduce signals leading to the differentiation or proliferation of cells.
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Ustekinumab Ustekinumab (INN, experimental name CNTO 1275, proprietary commercial name Stelara, Centocor) is a human monoclonal antibody. It is directed against interleukin 12 and interleukin 23, naturally occurring proteins that regulate the immune system and immune-mediated inflammatory disorders.
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- Diffuse interstitial lung disease (ILD) is a group of diseases that affect the connective tissue that forms the support structure of the air sacs, or alveoli, of the lungs.
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- : Interleukin-8 (IL-8) is a neutrophil chemokine that is encoded on the CXCL8 gene. Normally CXCL8 expression is repressed due to histone deacetylation, octamer-1 binding to the promoter and the inhibitory effect of nuclear factor-κB repressing factor (NRF).
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Diffuse Interstitial Lung Disease Diffuse interstitial lung disease (ILD) is a group of diseases that affect the connective tissue that forms the support structure of the air sacs, or alveoli, of the lungs. During normal inhalation, the alveoli fill with air. Oxygen within the air passes through the walls of the alveoli into the blood stream.
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Cytokine Cytokines produced by leukocytes are sometimes called interleukins, while those produced by lymphocytes may be referred to as lymphokines. Cytokines typically are not stored within the cell but instead are synthesized “on demand,” often in response to another cytokine. Once secreted, the cytokine binds to a specific protein molecule, called a receptor, on the surface of the target cell, an event that triggers a signaling cascade inside that cell.
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Human Interferon Alpha ELISA Plasma Matrix Study Abstract. 1  Accurate detection of Interferons (IFN) in serum or plasma samples by Enzyme-Linked Immunosorbent Assay (ELISA) is affected by interference from components in serum or plasma such as heterophilic antibodies and clotting factors. The interference from these different components is termed as matrix effect. In such cases, to evaluate the performance of an ELISA kit, a known concentration of IFN is added into IFN free plasma and the percentage difference between the concentration detected by ELISA and the actual amount is determined. This is known as Spike Recovery.
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Interferon Interferons (IFNs) are a group of signaling proteins[1] made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.
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- Interferon beta 1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS).It is produced by mammalian cells, while interferon beta 1b is produced in modified E. coli.nterferons are not a cure for MS (there is no cure); the claim is that interferons may slow the progress of the disease if started early and continued for the duration of the disease. Interferon beta 1a is sold under the trade names Avonex (Biogen) and Rebif (Merck Serono), (Pfizer); CinnoVex (CinnaGen) is biosimilar.
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Interferon Interferon was named for its ability to interfere with viral proliferation. The various forms of interferon are the body’s most rapidly produced and important defense against viruses. Interferons can also combat bacterial and parasitic infections, inhibit cell division, and promote or impede the differentiation of cells. They are produced by all vertebrate animals and possibly by some invertebrates as well. Interferons are categorized as cytokines, small proteins that are
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Diagnosis Interferons are naturally occurring substances that fight viruses and stimulate immune system cells. Gamma interferon is a manufactured (synthetic) substance given as an injection in the thigh or arm three times a week. It's used to treat chronic granulomatous disease, one form of primary immunodeficiency.
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interleukin one of several proteins important for lymphocyte proliferation. Interleukin-1 (IL-1) is produced by macrophages and induces the production of interleukin-2 by T cells that have been stimulated by antigen or mitogen.
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What Is Avonex (Interferon Beta-1a)? Avonex is the brand name of the injectable medicine interferon beta-1a, which is used to treat symptoms of relapsing multiple sclerosis (MS).Interferon beta-1a is also manufactured under the brand name Rebif. MS is a neurological condition where the immune system attacks the protective covering of nerves.Relapsing MS occurs when symptoms come and go. Avonex is in a class of drugs known as immunomodulators, which work by acting on the immune system.nterferon beta-1a is also manufactured under the brand name Rebif. MS is a neurological condition where the immune system attacks the protective covering of nerves. Relapsing MS occurs when symptoms come and go. Avonex is in a class of drugs known as immunomodulators, which work by acting on the immune system.
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- Siltuximab ( INN , trade name Sylvant ; also known as CNTO 328, anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins ) monoclonal antibody . It binds to interleukin-6 .
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- Interstitial lung disease, or ILD, is a common term that includes more than 100 chronic lung disorders, which may be: Nonmalignant (noncancerous). Noninfectious. Interstitial lung diseases are named after the tissue between the air sacs of the lungs called the interstitium--the tissue affected by fibrosis (scarring).