immune mediated thrombocytopenia definition
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- Mississippi State University College of Veterinary Medicine, Starkville, MS. Immune-mediated thrombocytopenia (IMT) is a relatively common cause of bleeding in small. animals, particularly the dog. Many differing disease processes may initiate IMT.
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Overcoming the diagnostic and therapeutic challenges of canine immune-mediated thrombocytopenia Platelets play an essential role in normal hemostasis. In primary hemostasis, platelets bind to the damaged vessel wall, forming an initial platelet plug. The platelet plug is then stabilized by fibrin, which is generated through the activation of clotting factors in secondary hemostasis. Immune-mediated thrombocytopenia is often diagnostically and therapeutically challenging. Understanding the underlying pathophysiology and principal differential diagnoses for thrombocytopenia in dogs is vital to develop an appropriate diagnostic and therapeutic approach.
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Humoral immunity Humoral immunity refers to antibody production and the accessory processes that accompany it, including: Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation.n incompatible blood transfusion causes a transfusion reaction, which is mediated by the humoral immune response. This type of reaction, called an acute hemolytic reaction, results in the rapid destruction (hemolysis) of the donor red blood cells by host antibodies.
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- Immune complex mediated vasculitis. Immune complex deposition in the blood vessel. wall triggers activation of the complement cas-. cade with recruitment of polymorphs and mac-. rophages, ampliﬁ cation of inﬂ ammation, and. the generation of lytic and injurious membrane.
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Immune thrombocytopenic purpura Idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenia, primary immune thrombocytopenic purpura or autoimmune thrombocytopenic purpura, is defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia.diopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenia, primary immune thrombocytopenic purpura or autoimmune thrombocytopenic purpura, is defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia.
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THROMBOCYTOPENIA blood disease, blood disorder - a disease or disorder of the blood. essential thrombocytopenia - the primary form of thrombocytopenia (rather than a shortage of platelets caused by other conditions such as tuberculosis or chemical suppression of bone marrow etc.) Translations. trombocitopénia.
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Immune Thrombocytopenia  (ITP) Idiopathic thrombocytopenic purpura (ITP) is a bleeding condition in which the blood doesn't clot as it should. This is due to a low number of blood cell fragments called platelets (PLATE-lets).Platelets also are called thrombocytes (THROM-bo-sites).They're made in your bone marrow along with other kinds of blood cells. Platelets stick together (clot) to seal small cuts or breaks on blood vessel walls and stop bleeding.his is due to a low number of blood cell fragments called platelets (PLATE-lets). Platelets also are called thrombocytes (THROM-bo-sites). They're made in your bone marrow along with other kinds of blood cells. Platelets stick together (clot) to seal small cuts or breaks on blood vessel walls and stop bleeding.
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Idiopathic thrombocytopenic purpura (ITP) Idiopathic thrombocytopenic purpura (ITP) Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. People with the disease have too few platelets in the blood. ITP is sometimes called immune thrombocytopenic purpura or simply, immune thrombocytopenia.
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Immune thrombocytopenic purpura Immune thrombocytopenia is a type of thrombocytopenic purpura defined as isolated low platelet count with normal bone marrow and the absence of other causes of thrombocytopenia. It causes a characteristic purpuric rash and an increased tendency to bleed. Two distinct clinical syndromes manifest as an acute condition in children and a chronic condition in adults. The acute form often follows an infection and has a spontaneous resolution within two months. Chronic immune thrombocytopenia persists longer than six months with a specific cause being unknown. ITP is an autoimmune disease with antibodies detectable against several platelet surface antigens. ITP is diagnosed by a low platelet count in a complete blood count (a common blood test).
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- Essential thrombocythaemia (ET; also known as essential thrombocytosis, essential thrombocythemia, primary thrombocytosis) is a rare chronic blood disorder characterised by the overproduction of platelets by megakaryocytes in the bone marrow.It may, albeit rarely, develop into acute myeloid leukaemia or myelofibrosis.ssential thrombocythaemia (ET; also known as essential thrombocytosis, essential thrombocythemia, primary thrombocytosis) is a rare chronic blood disorder characterised by the overproduction of platelets by megakaryocytes in the bone marrow. It may, albeit rarely, develop into acute myeloid leukaemia or myelofibrosis.
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Thrombocytosis Thrombocytosis is a disorder in which your body produces too many platelets (thrombocytes), which play an important role in blood clotting. The disorder is called reactive thrombocytosis or secondary thrombocythemia when it's caused by an underlying condition, such as an infection. Thrombocytosis (throm-boe-sie-TOE-sis) may also, less commonly, be caused by a blood and bone marrow disease. When caused by a bone marrow disorder, thrombocytosis is called autonomous, primary or essential thrombocytosis, or essential thrombocythemia. Your doctor may detect thrombocytosis in routine blood test results that show a high platelet level. If your blood test indicates thrombocytosis, it's important to determine whether it's reactive thrombocytosis or if you have essential thrombocythemia, which is more likely to cause blood clots.
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Lymphocytes? Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of macrophages and natural killer cells, the production of antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen.
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Idiopathic thrombocytopenic purpura (ITP) Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. Persons with the disease have too few platelets in the blood. ITP is sometimes called immune thrombocytopenic purpura or simply, immune thrombocytopenia.
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- A high MAGI can prevent you from contributing to a Roth IRA. For 2010, if you are married filing jointly or a qualifying widow, you cannot contribute to a Roth if your MAGI equals $176,000 or more.
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Immune (Idiopathic) Thrombocytopenia Purpura Idiopathic means the cause is unknown. Thrombocytopenia means a decreased number of platelets in the blood. Purpura refers to the purple discoloring of the skin, as with a bruise. The new name that is coming into use is immune thrombocytopenic purpura.
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Translations for cell-mediated immunity Cell-mediated immunity. Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen.D4 cells or helper T cells provide protection against different pathogens. Cytotoxic T cells cause death by apoptosis without using cytokines, therefore in cell mediated immunity cytokines are not always present.
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Thrombocythemia [edit on Wikidata] Thrombocytosis (or thrombocythemia) is the presence of high platelet counts in the blood, and can be either primary (also termed essential and caused by a myeloproliferative disease) or reactive (also termed secondary).
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thrombocytopenia Definition of thrombocytopenia : persistent decrease in the number of platelets in the blood that is often associated with hemorrhagic conditions thrombocytopenic
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- Immune-Mediated Platelet Destruction. In addition to ITP, there are other diseases where the involvement of the immune system causes platelet destruction in the bone marrow or in circulation, resulting in thrombocytopenia.
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- Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of exposure to heparin (ie, unfractionated heparin, low molecular weight [LMW] heparin) that occurs in up to 5 percent of patients exposed, regardless of the dose, schedule, or route of administration.
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Immune Thrombocytopenic Purpura (ITP) Practice Essentials. Immune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) (see the image below) manifests as a bleeding tendency, easy bruising (purpura), or extravasation of blood from capillaries into skin and mucous membranes (petechiae).
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HIV-Related Thrombocytopenia Zidovudine is effective treatment for HIV-related thrombocytopenia1 because it improves platelet production by the bone marrow2. Its effect on platelets may be distinct from its effect on HIV. Other anti-HIV drugs may not influence platelet production and may be ineffective against HIV-related thrombocytopenia.
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Immune thrombocytopenic purpura Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia. It causes a characteristic purpuric rash and an increased tendency to bleed.
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- Immune thrombocytopenic purpura. Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia. It causes a characteristic purpuric rash and an increased tendency to bleed.
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Thrombocytosis Primary thrombocytosis (also referred to as essential thrombocytosis, essential thrombocythaemia and primary thrombocythaemia) is due to a failure to regulate the production of platelets (autonomous production) and is a feature of a number of myeloproliferative disorders.
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Immune Thrombocytopenic Purpura (ITP) Practice Essentials. Immune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) (see the image below) manifests as a bleeding tendency, easy bruising (purpura), or extravasation of blood from capillaries into skin and mucous membranes (petechiae).ractice Essentials. Immune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) (see the image below) manifests as a bleeding tendency, easy bruising (purpura), or extravasation of blood from capillaries into skin and mucous membranes (petechiae).
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Thrombocytopenia Thrombocytopenia (THROM-bo-si-to-PE-ne-ah) is a condition in which your blood has a lower than normal number of blood cell fragments called platelets (PLATE-lets). Platelets are made in your bone marrow along with other kinds of blood cells.