```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Male-Respi-Antih@16:44:22</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Male</item_name>
            <item_key>\\i2b2_DEMO\i2b2\Demographics\Gender\Male\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Demographic \ Gender \ Male</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>2</hlevel>
            <item_name>Respiratory system</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Respiratory system (460-519)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Respiratory system</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>3</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>1</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Antihistamines</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME219) respiratory agents\(LME221) antihistamines\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ respiratory agents \ antihistamines</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find male patients who have been diagnosed with a respiratory condition and have not been prescribed antihistamines.