```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Involvement of @09:58:03</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Malignant neoplasms</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms \ Malignant neoplasms</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Involvement of regional lymph nodes / extent of spread</modifier_name>
                <modifier_key>\\i2b2_DIAG\TNM\Nodes\N2\</modifier_key>
                <applied_path>\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find all instances of malignant neoplasms (cancerous tumors) with involvement of regional lymph nodes or extent of spread, as classified by the ENC (Encounter) coding system, within any time frame, with a specificity scale of 0 and a panel accuracy scale of 100. The query will be applied to the Diagnoses section under the Neoplasms category in the i2b2 database.