```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Esophageal refl@15:39:03</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>5</hlevel>
            <item_name>Esophageal reflux</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Digestive system (520-579)\(530) Diseases of esophagus\(530-8) Other specified disorders~\(530-81) Esophageal reflux\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Diagnoses \ Digestive system \ Diseases of esophagus \ Other specified disorders of esophagus \ Esophageal reflux</tooltip>
            <class>ENC</class>
            <item_is_synonym>true</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find all instances of the diagnosis "Esophageal reflux" within the "Diagnoses" category, specifically under the subcategory of "Digestive system" and further under "Diseases of esophagus" and then "Other specified disorders of esophagus" using the i2b2 query builder with a specificity scale of 0 and accuracy scale of 100, with the total number of occurrences being 1, and the query timing set to "ANY."