```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Rheumatoid arthritis with rheumatoid factor-Methotrexate@10:46:12</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Rheumatoid arthritis with rheumatoid factor</item_name>
            <item_key>\\ICD10_ICD9\Diagnoses\(M00-M99) Dise~6mvn\(M00-M25) Arth~kgqv\(M05-M14) Infl~t2iu\(M05) Rheumato~npzf\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Diseases of the musculoskeletal system and connective tissue (m00-m99) \ Arthropathies (m00-m25) \ Inflammatory polyarthropathies (m05-m14)
 \ Rheumatoid arthritis with rheumatoid factor</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Methotrexate</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME178) miscellaneous agents\(LME182) antirheumatics\methotrexate\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ miscellaneous agents \ antirheumatics \ methotrexate</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find patients with a diagnosis of Rheumatoid arthritis with rheumatoid factor who have also been prescribed Methotrexate as a medication. This query is designed to search for patients with a specific combination of diagnosis and medication within the i2b2 database. The query will return results with a high level of accuracy, and it does not require a specific timeframe for the diagnosis or medication. The diagnosis of Rheumatoid arthritis with rheumatoid factor is classified under the ICD10 and ICD9 codes related to diseases of the musculoskeletal system and connective tissue, while Methotrexate is classified as a miscellaneous agent and an antirheumatic medication.