```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>(t) AsthmaAsthmaAsthma@20:18:49</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Asthma</item_name>
            <item_key>\\ICD10_ICD9\Diagnoses\(J00-J99) Dise~45pn\(J40-J47) Chro~fbox\(J45) Asthma\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Diseases of the respiratory system (j00-j99) \ Chronic lower respiratory diseases (j40-j47) \ Asthma</tooltip>
            <class>ENC</class>
            <item_is_synonym>true</item_is_synonym>
        </item>
    </panel>
    <subquery_constraint>
        <first_query>
            <query_id>Observation A</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>FIRST</aggregate_operator>
        </first_query>
        <operator>LESS</operator>
        <second_query>
            <query_id>Observation B</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>LAST</aggregate_operator>
        </second_query>
        <span>
            <operator>GREATEREQUAL</operator>
            <span_value>1000</span_value>
            <units>DAY</units>
        </span>
    </subquery_constraint>
    <subquery>
        <query_id>Observation A</query_id>
        <query_type>EVENT</query_type>
        <query_name>Observation A</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>0</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>3</hlevel>
                <item_name>Asthma</item_name>
                <item_key>\\ICD10_ICD9\Diagnoses\(J00-J99) Dise~45pn\(J40-J47) Chro~fbox\(J45) Asthma\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Diagnoses \ Diseases of the respiratory system (j00-j99) \ Chronic lower respiratory diseases (j40-j47) \ Asthma</tooltip>
                <class>ENC</class>
                <item_is_synonym>true</item_is_synonym>
            </item>
        </panel>
    </subquery>
    <subquery>
        <query_id>Observation B</query_id>
        <query_type>EVENT</query_type>
        <query_name>Observation B</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>0</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>3</hlevel>
                <item_name>Asthma</item_name>
                <item_key>\\ICD10_ICD9\Diagnoses\(J00-J99) Dise~45pn\(J40-J47) Chro~fbox\(J45) Asthma\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Diagnoses \ Diseases of the respiratory system (j00-j99) \ Chronic lower respiratory diseases (j40-j47) \ Asthma</tooltip>
                <class>ENC</class>
                <item_is_synonym>true</item_is_synonym>
            </item>
        </panel>
    </subquery>
</ns4:query_definition>

```

I want to find patients who have been diagnosed with asthma (J45) at least once within the same instance number as Observation A, and the last asthma diagnosis (J45) must be greater than or equal to 1000 days from the first asthma diagnosis (J45) recorded in Observation B.