```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Female@09:04:55</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Female</item_name>
            <item_key>\\i2b2_DEMO\i2b2\Demographics\Gender\Female\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Demographic \ Gender \ Female</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>5</hlevel>
            <item_name>Malignant neoplasm of brain</item_name>
            <item_key>\\ICD10_ICD9\Diagnoses\(C00-D49) Neop~k3n8\(C00-C96) Mali~yqqr\(C00-C75) Mali~lbm0\(C69-C72) Mali~8lvo\(C71) Malignan~7z3n\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms (c00-d49) \ Malignant neoplasms (c00-c96) \ Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue (c00-c75) \ Malignant neoplasms of eye, brain and other parts of central nervous system (c69-c72) \ Malignant neoplasm of brain</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>4</hlevel>
            <item_name>Temozolomide</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME55) antineoplastics\(LME56) alkylating agents\temozolomide\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ antineoplastics \ alkylating agents \ temozolomide</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>5</hlevel>
            <item_name>PLT ESTIMATE (LOINC:26515-7)</item_name>
            <item_key>\\i2b2_LABS\i2b2\Labtests\LAB\(LLB53) Hematology\(LLB57) Complete Blood Count\PLT\LOINC:26515-7\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Labtests \ Hematology \ Complete Blood Count \ PLT (Group:PLT) \ PLT ESTIMATE (LOINC:26515-7)</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>LT</value_operator>
                <value_constraint>50000</value_constraint>
                <value_unit_of_measure>k/ul</value_unit_of_measure>
                <value_type>NUMBER</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find female patients with a diagnosis of malignant neoplasm of the brain who have been prescribed temozolomide and have a platelet count estimated value less than 5000 k/ul.