```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Cocaine-Impoten@11:31:28</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Cocaine (Schedule I substance)</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME178) miscellaneous agents\(LME189) illicit (street) drugs\cocaine (Schedule I substance)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ miscellaneous agents \ illicit (street) drugs \ cocaine (schedule i substance)</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>4</hlevel>
            <item_name>Pyridostigmine</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME178) miscellaneous agents\(LME184) cholinergic muscle stimulants\pyridostigmine\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ miscellaneous agents \ cholinergic muscle stimulants \ pyridostigmine</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Impotence agents</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME178) miscellaneous agents\(LME190) impotence agents\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ miscellaneous agents \ impotence agents</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find patients who have been prescribed Cocaine (Schedule I substance) and/or Pyridostigmine, as well as those who have been prescribed Impotence agents, at any time in their medical history. The specificity scale is set to 0, meaning that the query will return all records that contain any of the specified items, regardless of the number of occurrences. The accuracy scale for each panel is set to 10, indicating that all items within the panel must be present for the record to be included in the results. The panel timing is set to ANY, meaning that the items can occur at any point in time. The class of the items is ENC, which stands for "Encounter", and the items are not synonyms. This query is designed to identify individuals who have been prescribed Cocaine or Pyridostigmine, and have also been prescribed Impotence agents.