```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns3:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/">
    <query_name>(t) zz V--Chole-De-IdCircuDiges@10:50:14</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>2</hlevel>
            <item_name>zz V-codes</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\zz V-codes\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ V-codes</tooltip>
            <class>ENC</class>
            <constrain_by_date>
                <date_from>1979-12-01T00:00:00.000-05:00</date_from>
            </constrain_by_date>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>5</hlevel>
            <item_name>UA-P/C - COLOR (LOINC:5778-6)</item_name>
            <item_key>\\i2b2_LABS\i2b2\Labtests\LAB\(LLB48) Urinalysis\(LLB49) Urinalysis\UA-COLOR\LOINC:5778-6\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Labtests \ Urinalysis \ Urinalysis \ Color (Group:UA-COLOR) \ Ua-p/c - color (LOINC:5778-6)</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>IN</value_operator>
                <value_constraint>('DK-YEL','STRAW CLEAR','YELLOW,CLEAR')</value_constraint>
                <value_type>TEXT</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Cholesterol (Group:CHOL)</item_name>
            <item_key>\\i2b2_LABS\i2b2\Labtests\LAB\(LLB16) Chemistry\(LLB17) Lipid Tests\CHOL\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Labtests \ Chemistry \ Lipid Tests \ Cholesterol (Group:CHOL)</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>GE</value_operator>
                <value_constraint>240</value_constraint>
                <value_unit_of_measure>mg/dl</value_unit_of_measure>
                <value_type>NUMBER</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>4</hlevel>
            <item_name>Cholesterol (Group:CHOL)</item_name>
            <item_key>\\i2b2_LABS\i2b2\Labtests\LAB\(LLB16) Chemistry\(LLB17) Lipid Tests\CHOL\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Labtests \ Chemistry \ Lipid Tests \ Cholesterol (Group:CHOL)</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>GE</value_operator>
                <value_constraint>240</value_constraint>
                <value_unit_of_measure>mg/dl</value_unit_of_measure>
                <value_type>NUMBER</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>3</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>2</hlevel>
            <item_name>De-Identified X-Ray Reports</item_name>
            <item_key>\\i2b2_REP\i2b2\Reports\De-Identified X-Ray Reports\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>\ i2b2 \ Reports \ De-Identified X-Ray Reports \</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>CONTAINS</value_operator>
                <value_constraint>fracture</value_constraint>
                <value_type>LARGETEXT</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>2</hlevel>
            <item_name>De-Identified X-Ray Reports</item_name>
            <item_key>\\i2b2_REP\i2b2\Reports\De-Identified X-Ray Reports\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>\ i2b2 \ Reports \ De-Identified X-Ray Reports \</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>CONTAINS[database]</value_operator>
                <value_constraint>broken</value_constraint>
                <value_type>LARGETEXT</value_type>
            </constrain_by_value>
            <constrain_by_date>
                <date_to>2018-01-30T00:00:00.000-05:00</date_to>
            </constrain_by_date>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <subquery_constraint>
        <first_query>
            <query_id>Event 1</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>FIRST</aggregate_operator>
        </first_query>
        <operator>LESS</operator>
        <second_query>
            <query_id>Event 2</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>FIRST</aggregate_operator>
        </second_query>
    </subquery_constraint>
    <subquery>
        <query_id>Event 1</query_id>
        <query_type>EVENT</query_type>
        <query_name>Event 1</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>1</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>2</hlevel>
                <item_name>Circulatory system</item_name>
                <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Circulatory system (390-459)\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Diagnoses \ Circulatory system</tooltip>
                <class>ENC</class>
                <constrain_by_date>
                    <date_from>1979-12-01T00:00:00.000-05:00</date_from>
                </constrain_by_date>
                <item_is_synonym>false</item_is_synonym>
            </item>
        </panel>
    </subquery>
    <subquery>
        <query_id>Event 2</query_id>
        <query_type>EVENT</query_type>
        <query_name>Event 2</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>1</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>2</hlevel>
                <item_name>Digestive system</item_name>
                <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Digestive system (520-579)\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Diagnoses \ Digestive system</tooltip>
                <class>ENC</class>
                <constrain_by_date>
                    <date_to>2018-01-30T00:00:00.000-05:00</date_to>
                </constrain_by_date>
                <item_is_synonym>false</item_is_synonym>
            </item>
        </panel>
    </subquery>
</ns3:query_definition>

```

I want to find patients with a diagnosis of a circulatory system condition (ICD code 390-459) and a de-identified x-ray report containing the term "fracture" in the same instance, while excluding patients with a digestive system diagnosis (ICD code 520-579) and a de-identified x-ray report containing the term "broken" in the same instance, where the first event (circulatory system diagnosis) occurred before the second event (digestive system diagnosis).