```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Asthma@10:37:38</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Asthma</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Respiratory system (460-519)\Chronic obstructive diseases (490-496)\(493) Asthma\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Respiratory system \ Chronic obstructive diseases \ Asthma</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find patients with a diagnosis of asthma in the respiratory system category, specifically under chronic obstructive diseases, using the i2b2 query builder with the specificity scale set to 0, accuracy scale at 100, and the query timing set to ANY. The query will focus on a single panel with panel timing set to ANY and a total of one item occurrence. The specific item being searched is the ICD-10 code for asthma, which is (493), and the query will return encounters where this diagnosis was recorded.