```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns3:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/">
    <query_name>Other-Centr-Affym@09:12:36</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>2</hlevel>
            <item_name>Other degenerative diseases of the nervous system (g30-g32)</item_name>
            <item_key>\\ICD10_ICD9\Diagnoses\(G00-G99) Dise~j8kq\(G30-G32) Othe~kdmb\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Diseases of the nervous system (g00-g99) \ Other degenerative diseases of the nervous system (g30-g32)</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Principal Diagnosis</modifier_name>
                <modifier_key>\\ICD10_ICD9\Principal Diagnosis\</modifier_key>
                <applied_path>\Diagnoses\(G00-G99) Dise~j8kq\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>2</hlevel>
            <item_name>Central nervous system agents</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME92) central nervous system agents\</item_key>
            <item_icon>FAO</item_icon>
            <tooltip>medications \ central nervous system agents</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Patient Instructions</modifier_name>
                <modifier_key>\\i2b2_MEDS\Medication\Instructions\</modifier_key>
                <applied_path>\i2b2\Medications\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>3</hlevel>
            <item_name>Family history</item_name>
            <item_key>\\i2b2_REP\i2b2\Reports\Medical History\Family History\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>i2b2 \ Reports \ Medical History \ Family History</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>LIKE[contains]</value_operator>
                <value_constraint>ALS</value_constraint>
                <value_unit_of_measure></value_unit_of_measure>
                <value_type>TEXT</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>3</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>2</hlevel>
            <item_name>Affymetrix HG-U133</item_name>
            <item_key>\\i2b2_EXPR\i2b2\Expression Profiles Data\Affymetrix HG-U133\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Expression Profiles Data\Affymetrix HG-U133</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns3:query_definition>

```

I want to find patients with a principal diagnosis of other degenerative diseases of the nervous system (ICD-9 codes G30-G32) who have been prescribed central nervous system agents (medications) and have a family history that contains "ALS" (Amyotrophic Lateral Sclerosis) in their medical reports, as well as those who have Affymetrix HG-U13 expression profiles available.