```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Fem-Mal-Tem-PLT@14:37:05</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Female</item_name>
            <item_key>\\i2b2_DEMO\i2b2\Demographics\Gender\Female\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Demographic \ Gender \ Female</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>5</hlevel>
            <item_name>Malignant neoplasm of brain</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\Unspecified sites (190-199)\(191) Malignant neoplasm of brain\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms \ Malignant neoplasms \ Unspecified sites \ Malignant neoplasm of brain</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>3</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Temozolomide</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME55) antineoplastics\(LME56) alkylating agents\temozolomide\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ antineoplastics \ alkylating agents \ temozolomide</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>4</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>5</hlevel>
            <item_name>PLT ESTIMATE (LOINC:26515-7)</item_name>
            <item_key>\\i2b2_DEMO\i2b2\Labtests\LAB\(LLB53) Hematology\(LLB57) Complete Blood Count\PLT\LOINC:26515-7\</item_key>
            <item_icon>LA</item_icon>
            <tooltip>Labtests \ Hematology \ Complete Blood Count \ PLT (Group:PLT) \ PLT ESTIMATE (LOINC:26515-7)</tooltip>
            <class>ENC</class>
            <constrain_by_value>
                <value_operator>LT</value_operator>
                <value_constraint>50000</value_constraint>
                <value_unit_of_measure>k/ul</value_unit_of_measure>
                <value_type>NUMBER</value_type>
            </constrain_by_value>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find female patients with a diagnosis of malignant neoplasm of the brain who have been prescribed temozolomide and have a platelet count estimated value (PLT) less than 5000 k/ul at any time.