```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Accolate 20mg tablet Astra-Zeneca Pharmaceuticals@14:46:19</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>1</hlevel>
            <item_name>Accolate 20mg tablet Astra-Zeneca Pharmaceuticals</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME219) respiratory agents\(LME229) leukotriene modifiers\zafirlukast\00310040239\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ respiratory agents \ leukotriene modifiers \ zafirlukast \ accolate 20mg tablet astra-zeneca pharmaceuticals</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Patient Instructions</modifier_name>
                <modifier_key>\\i2b2_MEDS\Medication\Instructions\</modifier_key>
                <applied_path>\i2b2\Medications\%</applied_path>
                <constrain_by_value>
                    <value_operator>CONTAINS</value_operator>
                    <value_constraint>test</value_constraint>
                    <value_type>LARGETEXT</value_type>
                </constrain_by_value>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find any instances where the medication "Accolate 20mg tablet" by Astra-Zeneca Pharmaceuticals has been prescribed to patients, with a high level of accuracy and no specific time frame. This query will search for the medication within the "Medications" category, specifically under the "respiratory agents" and "leukotriene modifiers" subcategories, and the tooltip will display "medications \ respiratory agents \ leukotriene modifiers \ zafirlukast \ accolate 20mg tablet astra-zeneca pharmaceuticals." The query will also be constrained by the "Patient Instructions" modifier, looking for any instances where the value "test" is contained within the "Medications" category.