```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Malignant neoplasms@10:29:10</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Malignant neoplasms</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms \ Malignant neoplasms</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Distant metastasis cannot be evaluated</modifier_name>
                <modifier_key>\\i2b2_DIAG\TNM\Metastisis\MX\</modifier_key>
                <applied_path>\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>3</hlevel>
            <item_name>Malignant neoplasms</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms \ Malignant neoplasms</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Distant metastasis is present</modifier_name>
                <modifier_key>\\i2b2_DIAG\TNM\Metastisis\M1\</modifier_key>
                <applied_path>\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
        <item>
            <hlevel>3</hlevel>
            <item_name>Malignant neoplasms</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms \ Malignant neoplasms</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>No distant metastasis</modifier_name>
                <modifier_key>\\i2b2_DIAG\TNM\Metastisis\M0\</modifier_key>
                <applied_path>\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find all instances of malignant neoplasms (ICD-10 code 140-208) with no specific timing, regardless of their specificity, and constrain the results by the presence or absence of distant metastasis. Specifically, I want to include cases where distant metastasis cannot be evaluated, as well as those where it is present (M1) or absent (M0). The query will look for these diagnoses in the i2b2 Diagnoses module, under the Neoplasms (140-239) category.