```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>(t) Diabete-AtorvasAntihypAnencep@11:49:34</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>6</hlevel>
            <item_name>Diabetes mellitus type II [non-insulin dependent type] [NIDDM type] [adult-onset type] or unspecified type, not stated as uncontrolled, with unspecified complication</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Endocrine disorders (240-259)\Other endocrine gland diseases (250-259)\(250) Diabetes mellitus\(250-9) Diabetes with unspecified~\(250-90) Diabetes mellitus type I~\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ ... \ Diabetes mellitus type II [non-insulin dependent t{..}cified type, not stated as uncontrolled, with unspecified complication</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <panel>
        <panel_number>2</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>4</hlevel>
            <item_name>Atorvastatin</item_name>
            <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME5) antihyperlipidemic agents\(LME8) HMG-CoA reductase inhibitors\atorvastatin\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>medications \ antihyperlipidemic agents \ hmg-coa reductase inhibitors \ atorvastatin</tooltip>
            <class>ENC</class>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
    <subquery_constraint>
        <first_query>
            <query_id>Observation A</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>FIRST</aggregate_operator>
        </first_query>
        <operator>LESS</operator>
        <second_query>
            <query_id>Observation B</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>FIRST</aggregate_operator>
        </second_query>
    </subquery_constraint>
    <subquery>
        <query_id>Observation A</query_id>
        <query_type>EVENT</query_type>
        <query_name>Observation A</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>0</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>2</hlevel>
                <item_name>Antihyperlipidemic agents</item_name>
                <item_key>\\i2b2_MEDS\i2b2\Medications\MUL\(LME5) antihyperlipidemic agents\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>medications \ antihyperlipidemic agents</tooltip>
                <class>ENC</class>
                <item_is_synonym>false</item_is_synonym>
            </item>
        </panel>
    </subquery>
    <subquery>
        <query_id>Observation B</query_id>
        <query_type>EVENT</query_type>
        <query_name>Observation B</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>0</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>4</hlevel>
                <item_name>Anencephalus</item_name>
                <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Congenital anomalies (740-759)\(740) Anencephalus and similar an~\(740-0) Anencephalus\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Diagnoses \ Congenital anomalies \ Anencephalus and similar anomalies \ Anencephalus</tooltip>
                <class>ENC</class>
                <item_is_synonym>true</item_is_synonym>
            </item>
            <item>
                <hlevel>2</hlevel>
                <item_name>Circulatory system</item_name>
                <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Circulatory system (390-459)\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Diagnoses \ Circulatory system</tooltip>
                <class>ENC</class>
                <item_is_synonym>false</item_is_synonym>
            </item>
        </panel>
    </subquery>
</ns4:query_definition>

```

I want to find patients with a diagnosis of diabetes mellitus type II, not stated as uncontrolled, with unspecified complication, who have been prescribed atorvastatin, and have no record of antihyperlipidemic agents other than atorvastatin in their medical history. Additionally, I want to find patients with a diagnosis of anencephaly and any other circulatory system-related diagnoses in their medical history.