```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>(t) Medications-Medications@14:52:51</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <subquery_constraint>
        <first_query>
            <query_id>Event 1</query_id>
            <join_column>ENDDATE</join_column>
            <aggregate_operator>ANY</aggregate_operator>
        </first_query>
        <operator>LESS</operator>
        <second_query>
            <query_id>Event 2</query_id>
            <join_column>STARTDATE</join_column>
            <aggregate_operator>FIRST</aggregate_operator>
        </second_query>
        <span>
            <operator>EQUAL</operator>
            <span_value>2</span_value>
            <units>DAY</units>
        </span>
        <span>
            <operator>GREATEREQUAL</operator>
            <span_value>3</span_value>
            <units>DAY</units>
        </span>
    </subquery_constraint>
    <subquery>
        <query_id>Event 1</query_id>
        <query_type>EVENT</query_type>
        <query_name>Event 1</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>1</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>1</hlevel>
                <item_name>Medications</item_name>
                <item_key>\\i2b2_MEDS\i2b2\Medications\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Medications</tooltip>
                <class>ENC</class>
                <constrain_by_modifier>
                    <modifier_name>Patient Instructions</modifier_name>
                    <modifier_key>\\i2b2_MEDS\Medication\Instructions\</modifier_key>
                    <applied_path>\i2b2\Medications\%</applied_path>
                </constrain_by_modifier>
                <item_is_synonym>false</item_is_synonym>
            </item>
        </panel>
    </subquery>
    <subquery>
        <query_id>Event 2</query_id>
        <query_type>EVENT</query_type>
        <query_name>Event 2</query_name>
        <query_timing>SAMEINSTANCENUM</query_timing>
        <specificity_scale>0</specificity_scale>
        <panel>
            <panel_number>1</panel_number>
            <panel_timing>SAMEINSTANCENUM</panel_timing>
            <panel_accuracy_scale>100</panel_accuracy_scale>
            <invert>0</invert>
            <total_item_occurrences>1</total_item_occurrences>
            <item>
                <hlevel>1</hlevel>
                <item_name>Medications</item_name>
                <item_key>\\i2b2_MEDS\i2b2\Medications\</item_key>
                <item_icon>FA</item_icon>
                <tooltip>Medications</tooltip>
                <class>ENC</class>
                <constrain_by_modifier>
                    <modifier_name>Route</modifier_name>
                    <modifier_key>\\i2b2_MEDS\Medication\Route\</modifier_key>
                    <applied_path>\i2b2\Medications\%</applied_path>
                </constrain_by_modifier>
                <item_is_synonym>false</item_is_synonym>
            </item>
        </panel>
    </subquery>
</ns4:query_definition>

```

I want to find all instances of medication events where the end date of the first event is less than or equal to two days ago and the start date of the second event is greater than or equal to three days ago, within the same instance number, and where the first event is constrained by the 'Patient Instructions' modifier and the second event is constrained by the 'Route' modifier.