```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns4:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/">
    <query_name>Malignant neoplasms@16:10:59</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>3</hlevel>
            <item_name>Malignant neoplasms</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ Neoplasms \ Malignant neoplasms</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Involvement of regional lymph nodes / extent of spread</modifier_name>
                <modifier_key>\\i2b2_DIAG\TNM\Nodes\N2\</modifier_key>
                <applied_path>\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns4:query_definition>

```

I want to find all cases of malignant neoplasms, regardless of the specific type or location, with no specificity scale applied, and constrained by the involvement of regional lymph nodes or extent of spread. The query is set to have a high accuracy scale and the information will be retrieved from the Diagnoses section, specifically within the Neoplasms category under the Malignant neoplasms subcategory. The query is named "Malignant neoplasms@16:10:59" and the timing is set to ANY, meaning it can be any time in the patient's medical history.