```xml
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ns3:query_definition xmlns:ns2="http://www.i2b2.org/xsd/cell/crc/psm/1.1/" xmlns:ns4="http://www.i2b2.org/xsd/cell/crc/psm/analysisdefinition/1.1/" xmlns:ns3="http://www.i2b2.org/xsd/cell/crc/psm/querydefinition/1.1/">
    <query_name>Tumor large in @10:16:25</query_name>
    <query_timing>ANY</query_timing>
    <specificity_scale>0</specificity_scale>
    <panel>
        <panel_number>1</panel_number>
        <panel_timing>ANY</panel_timing>
        <panel_accuracy_scale>100</panel_accuracy_scale>
        <invert>0</invert>
        <total_item_occurrences>1</total_item_occurrences>
        <item>
            <hlevel>6</hlevel>
            <item_name>Other malignant neoplasm of other specified sites of skin</item_name>
            <item_key>\\i2b2_DIAG\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\Bone, connective tissue, skin, and breast (170-176)\(173) Other malignant neoplasm of~\(173-8) Other malignant neoplasm ~\</item_key>
            <item_icon>FA</item_icon>
            <tooltip>Diagnoses \ ... \ Bone, connective tissue, skin, and breast \ Other malignant neoplasm of skin \ Other malignant neoplasm of other specified sites of skin</tooltip>
            <class>ENC</class>
            <constrain_by_modifier>
                <modifier_name>Tumor large in size</modifier_name>
                <modifier_key>\\i2b2_DIAG\TNM\Tumor\T3\</modifier_key>
                <applied_path>\i2b2\Diagnoses\Neoplasms (140-239)\Malignant neoplasms (140-208)\%</applied_path>
            </constrain_by_modifier>
            <item_is_synonym>false</item_is_synonym>
        </item>
    </panel>
</ns3:query_definition>

```

I want to find patients with a diagnosis of "Other malignant neoplasm of other specified sites of skin" (ICD-10 code C44.8) who have a "Tumor large in size" (T3) modifier applied to their diagnosis. The query will search for these cases at any time in the patient's medical record and will have a high accuracy level of 100. This query will be part of a panel with panel number 1 and panel timing set to ANY.