Resutf of treatment shows CR 41 (97.3%), CNV replapse 1 (3, 7%), toxic associated with high dose methotrexate consist of: Neutropenia 8 (18%), thrombocytopenia 6 (13.8%), stomatitis17 (38, 6%), elevated transaminase levels 11 (25%) and delay toxic of encephalopathy: headache 2 (4, 5%); cortical: 3 (6, 8%).