In patients allergic to penicillin, clindamycin 300 to 450 mg 3 times a day plus either an oral fluoroquinolone (eg, ciprofloxacin 500 mg every 12 hours) or double-strength sulfamethoxazole / trimethoprim (800 mg sulfamethoxazole/160 mg trimethoprim) orally 2 times a day may be used.