The study named: Study the effects of knee intra-articular autologous platelet - rich plasma therapy in treatment of primary knee osteoarthritis Major: Internal Rheumatology; Code: 62720142 Fellows: Bùi Hải Bình, 30th course Supervisor: Assoc. Prof Nguyen Thi Ngoc Lan Training address: Hanoi Medical University New contributions of the thesis: This is the first study to use knee intra-articular autologous platelet - rich plasma therapy in treatment of primary knee osteoarthritis stage 2 - 3 in Vietnam Study characteristics of blood cells and transforming growth factor beta-1 (TGF-β1) level in autologous platelet - rich plasma isolated by ACP (Arthrex) separation: platelet count in PRP were double higher in whole blood cell but white blood cell count was in small amount; TGF - β1 concentrations in PRP was 148, 6 ng / ml, higher than that was 13, 8 ng / ml in whole blood.