Results: In 3, 5 years 2016 and 2019, retrospectively 36 cases using pemetrexed + platinum chemotherapy was divided into 2 groups including 20 patients on first - line treatment and 16 patients on second - line treatment, overall response rate was 52.8%; median duration of response was 11.7 cycles; median progression - free survival 7.1 months; (median overall survival in this population was 15.8 months; overall 1 - year survival rate was 66.7%.