Polyglandular Deficiency Syndromes (Autoimmune Polyglandular Syndromes; Polyendocrine Deficiency Syndromes) By Jennifer M Barker, MD, Children's Hospital Colorado, Division of Pediatric Endocrinology Reviewed / Revised Apr 2023 View Patient Education Etiology Pathophysiology Classification Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Characteristics of Polyglandular... Polyglandular deficiency syndromes are characterized by sequential or concurrent deficiencies in the function of several endocrine glands that have a common cause.