Treatment of Alpha-1 Antitrypsin Deficiency Supportive care For pulmonary disease, often alpha-1 antitrypsin replacement Treatment of pulmonary disease is with purified human alpha-1 antitrypsin (60 mg / kg IV over 45 to 60 minutes given once a week or 250 mg / kg over 4 to 6 hours given once a month [pooled only]), which can maintain the serum alpha-1 antitrypsin level above a target protective level of 80 mg / dL (35% of normal).