There are 116 Neonatal jaundice (7 cases transfusion): 23 cases premature and low birth weight, 57 cases cesarean section, 11 cases VE and 25 cases normal delivery. Objective: Evaluation of efficacy and safety phototherapy and blood transfusion in newborn at Neonatal department - Sihospital. Material & Methods: prospective descriptive trial. Results: 95% nurses carry out exact medical instruction, 100% nurses perform right process blood transfusion of Ministry of health.