Diagnosis of Lymphangioleiomyomatosis Chest x-ray and high-resolution CT (HRCT) VEGF-D testing Lung biopsy if HRCT and VEGF-D testing are nondiagnostic Diagnosis of lymphangioleiomyomatosis is suspected in young women with dyspnea plus interstitial changes with normal or increased lung volumes on chest x-ray, spontaneous pneumothorax, or chylous effusion.