TLR5 + 1174 polymorphism was a functional polymorphism of the gen TLR5 and was considered to be worth to be studied in the association with H pylori infection or gastric cancer risk. Aims: Anylyzing TLR5 + 1174 polymorphism in three control ethnic groups resident in Malaysia including Chinese, Indian and Malay. Evaluating the association between this SNP (Single Nucleotide Polymorphism) with H pylori infection or gastric cancer risk. Methods: Two groups include 370 subjects participating in the study; a control group including 123 Chinese, 108 Indians and 84 Malays; and a case group of 55 Chinese gastric cancers.