Reactive airways dysfunction syndrome (RADS) and irritant-induced asthma Reactive airways dysfunction syndrome (RADS) is the rapid onset (minutes to hours, but not > 24 hours) of an asthma-like syndrome that Develops in people with no history of asthma Occurs following a single, specific inhalation exposure to a significant amount of an irritating gas or particulate Persists for ≥ 3 months Numerous substances have been implicated, including chlorine gas, nitrogen oxide, and volatile organic compounds (eg, from paints, solvents, adhesives).