Objectives: survey epidemiological and clinical characteristics of patients with infective endocarditis (IE) at Cho Ray hospital in ten years (2000 - 2009). Methods: a retrospective, cross-sectional and descriptive study on all patients who were admitted to Department of Cardiology, Cho Ray Hospital from 1/1/2000 to 31/12/2009 and fulfilled the modified Duke criteria for diagnosis of IE Results: There were 225 patients with IE hospitalized in ten years.