So, the aim of this study was not only to determine the rate of thyroid cancer in patients with multinodular goiters hospitalized at Cancer hospital but also to explore its clinical and paraclinical charecteristics, contributing to diagnosing pre-surgical thyroid cancer episodes among patients with multinodular goiters. Materials and methods: reviewing 81 patients with thyroid cancer in multinodular goiters treated in Ho Chi Minh City Cancer Center from 01/01/2009 to 30/06/2009.Results: Thyroid carcinoma was identified in 25.9% of totally multinodular goiter cases.