Clinical and subclinical features of lung cancer patients with EGFR mutations when resistance to EGFR-TKIs Clinical features: the most common respiratory symptoms were cough (57.6%), chest pain (48.5%), and dyspnea (45.5%); most common systemic symptoms were weight loss (15.2%), peripheral lymph node (12.1%); most common metastatic symptoms were headache (15.2%), spinal pain (12.1%).