There are multiple options for CRC screening, including Colonoscopy every 10 years Fecal occult blood test annually (fecal immunochemical tests [FIT] preferred) Flexible sigmoidoscopy every 5 years (every 10 years if combined with FIT) CT colonography every 5 years Fecal DNA testing combined with FIT every 3 years The ACG colorectal cancer screening guidelines recommend colonoscopy every 10 years or annual FIT as the preferred screening tests.