Systemic Abnormalities in Liver Disease By Danielle Tholey, MD, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Jan 2023 View Patient Education Circulatory Abnormalities Endocrine Abnormalities Hematologic Abnormalities Renal and Electrolyte Abnormalities Pulmonary Abnormalities Liver disease often causes systemic symptoms and abnormalities.