If a pathogen is isolated on culture, the antibiotic regimen is adjusted as needed, as for the following: For group A streptococci: Clindamycin plus a beta-lactam For methicillin-susceptible S aureus (MSSA): Clindamycin plus oxacillin or nafcillin For methicillin-resistant Staphylococcus aureus (MRSA): Vancomycin or daptomycin plus clindamycin or linezolid, depending on the susceptibility Antibiotics given during the acute illness may eradicate pathogen foci and prevent recurrences.