Ulcerative Colitis By Aaron E Walfish, MD, Mount Sinai Medical Center; Rafael Antonio Ching Companioni, MD, HCA Florida Gulf Coast Hospital Reviewed / Revised Jan 2022 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Ileal Pouch-Anal Anastomosis... Ulcerative Colitis Pseudopolyps Overview of Ulcerative Colitis Ulcerative colitis is a chronic inflammatory and ulcerative disease arising in the colonic mucosa, characterized most often by bloody diarrhea.