To evaluate the effectiveness of eltrombopag in aldult chronic / persistent immune thrombocytopenia at Blood Transfusion Hospital Subjects and Methods: This was a descriptive case series study. We retrospectively reviewed the medical recorded records clinical, laboratory test, the response and outcome of treatment and side effects of eltrombopag from January 2018 to December 2021 Results: 21 patients were included in this study, average age was 38, 1 year-old, with female predominance over male.