Health-related quality of life has multiple dimensions, including the following: Absence of distressing physical symptoms (eg, pain, dyspnea, nausea, constipation) Emotional well-being (eg, happiness, absence of anxiety) Physical and cognitive functional status (eg, capacity to do activities of daily living and higher-order functions, such as pleasurable activities) Quality of close interpersonal relationships (eg, with family members, friends) Participation in and enjoyment of social activities Satisfaction with medical and financial aspects of treatments Sexuality, body image, and intimacy Influences Some of the factors that influence health-related quality of life (eg, reduced life expectancy, cognitive impairment, disability, chronic pain, social isolation, functional status, dependency on caregivers) may be obvious to health care practitioners.