Table Staging Esophageal Cancer * Stage Tumor (maximum penetration) Regional Lymph Node Metastasis Distant Metastasis 0 Tis N0 M0 I T1 N0 M0 II T2 or T3 N0 M0 III T3 or T4 N1 M0 IV Any T Any N M1 * cTNM classification (clinical staging): Tis = carcinoma in situ; T1 = lamina propria or submucosa; T2 = muscularis propria; T3 = adventitia; T4 = adjacent structures.