Objectives: To seek for the sensitivity and specificity of fetal echocardiography in prenatal diagnosis of congenital heart disease (CHD). Background: Echography is a reliable tool in detection of fetal defect, we don't know the accuracy of fetal echocardiography in detection CHD in Việt Nam. Methods: Cohort study of the women with gestational age from 16 to 28 weeks sent from obstetrical hospital, who live in HCMC Results: From May 2007 to May 2010 there were 2634 pregnances selected, were conducted echocardiography at Heart Institute in HCMC.