Patients at increased risk of non-Hodgkin lymphoma include those with Primary immunodeficiency Secondary immunodeficiency (eg, when induced by immunosuppressive drugs, such as those used in rheumatologic disorders and post-solid organ transplant) Exposure to certain chemicals (eg, some herbicides and insecticides) Chronic inflammation and reactive lymph node hyperplasia Non-Hodgkin lymphoma is the 2nd most common cancer in HIV-infected patients, and some AIDS patients present with lymphoma.