The highest rates occur in Low-birth-weight (LBW) infants Infants with depressed function at birth as manifested by a low Apgar score Infants with maternal perinatal risk factors (eg, low socioeconomic status, premature rupture of membranes) Minorities Males Etiology of Neonatal Sepsis Onset of neonatal sepsis can be Early (≤ 3 days of birth) Late (after 3 days) Early-onset neonatal sepsis Early-onset neonatal sepsis usually results from organisms acquired intrapartum.