POEMS Syndrome (Crow-Fukase Syndrome; Takatsuki Disease; PEP Syndrome) By Jennifer M Barker, MD, Children's Hospital Colorado, Division of Pediatric Endocrinology Reviewed / Revised Apr 2023 View Patient Education Symptoms and Signs Diagnosis Treatment POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) is a nonautoimmune polyglandular deficiency syndrome.