The most common etiologies include Mechanical trauma or muscle ischemia (eg, crush injuries, electric shocks, seizures, or compartment syndrome) Drugs and toxins (eg, statins, antibiotics, anxiolytics, antipsychotics, cocaine, amphetamines, alcohol) Infection (eg, influenza A and B, coxsackievirus, Staphylococcus aureus) Less common etiologies include Electrolyte disorders (eg, hypokalemia, hypophosphatemia) Endocrine disorders (eg, diabetic ketoacidosis and nonketotic hyperglycemia) Genetic disorders (eg, Duchenne muscular dystrophy, Becker muscular dystrophy) Extreme exercise or prolonged immobilization Extremes in body temperature (eg, hypothermia, hyperthermia in neuroleptic malignant syndrome or malignant hyperthermia, and heatstroke) Symptoms and Signs of Rhabdomyolysis The classic triad of symptoms in rhabdomyolysis is muscle pain, weakness, and reddish-brown urine.