We developed methods on LC-MS / MS to detect synthesis pharmaceutical drugs in following groups of HSP: strengthen sexual for man group: sildenafil, Tadalafil, Vardenafil; Anti - arthritis group: Dexamethasone, Prednisolon, Betamethasone, Piroxicam; Slimming group: Sibutramin, Orlistate, Phenophtalein, Furosemid.