Indications Laceration or other surgically treated skin lesion Foreign body removal Incision and drainage Contraindications Absolute contraindications History of allergy to the anesthetic agent or delivery vehicle (choose a different anesthetic) Relative contraindications Large wounds (local infiltration of which may require toxic amounts of anesthetic) * Wounds requiring precise anatomic alignment (eg, vermilion border lip lacerations), for which wound edge distortion caused by infiltration is problematic * * Nerve blocks and procedural sedation and analgesia should be used as needed.