Aims: To evaluate the efficacy of 10day levofloxacin containing sequential therapy as first-line treatment for H pylori eradication, side effects, symptoms and endoscopic responses and improvement of histological features in Centre Vietnam. Patients and methods: 120 Naïve H pylori positive patients were received levofloxacin containing sequential therapy (rabeprazole 20mg twice daily, amoxicillin 1g twice daily for 5 days followed by rabeprazole 20mg, levofloxacin 500mg, and tinidazole 500mg, twice daily for 5 more days).