The ratio of IL-6/IL-10 was 9.28 (3.59 - 30.03) and IL-10/TNF- was 1.13 (0.44 - 4.06). Conclusion: We quantified 10 risk factors of death in ICU patients with MOD included (1) serum pH < 7.10; (2) IL-10/TNF- ratio  5, (3) SOFA scores ≥ 10, (4) patient with over 3 organs failured, (5) patient with hypotension / septic shock, (6) APACHE II scores  25, (7) serum IL-10 ≥ 50 pg / mL, (8) serum IL-6  100 pg / mL, (9) patient with mechanical ventilation and (10) patient over 55 year old.