Bisphosphonates include the following: Alendronate (10 mg once a day or 70 mg orally once a week) Risedronate (5 mg orally once a day, 35 mg orally once / week, or 150 mg orally once a month) Zoledronic acid (5 mg IV once a year) Ibandronate (150 mg orally once a month or 3 mg IV once every 3 months) Evidence supports a treatment duration with oral alendronate for 5 years or with IV zoledronic acid for 3 to 6 years (1).