Objectives: Assess pain and quality of life in advanced cancer patients from 7/2009 to 7/2010 in HCMC Oncology Hospital. Methods: Cross-sectional study: interview 256 patients in Departments of Medical Oncology in HCMC Oncology Hospital using Brief Pain Inventory and EORTC QLQ 30 from July to September 2009Results: The result showed that there was 73.3 percent were suffering from pain during the research of 256 patients, and among that was 63% reported pain rates under 5 points.