If clinical evidence for urethritis is uncertain, the Centers for Disease Control and Prevention (CDC) 2021 Sexually Transmitted Infections Treatment Guidelines state that urethritis can be documented by any of the following: Mucoid, mucopurulent, or purulent discharge observed during examination ≥ 10 white blood cells per high-power field in spun first-void urine A positive leukocyte esterase test on first-void urine ≥ 2 white blood cells per oil immersion field in Gram-stained urethral secretions Samples of cervical or vaginal specimens or male urethral or rectal exudates are obtained to check for chlamydiae.