For patients who meet diagnostic criteria, other causes of hirsutism or virilization (eg, androgen-secreting tumors) should be excluded by measuring serum androgens including Total testosterone Early-morning serum 17 - hydroxyprogesterone is measured to exclude adrenal virilism DHEAS, if abnormal, women are evaluated as for amenorrhea Serum free testosterone is more sensitive than total testosterone but is technically more difficult to measure (see algorithm Diagnosis of primary and secondary hypogonadism).