Several effective factor are: age, severe chronic disease, patients severity score, bad nutrition, late of diagnosis posoperative peritonitis, late therapy sepsis before admission to the ICU, apprance of multiorgan failure, decrease of albumin concentration, appearance of nosocomia. Conclusion: Close up vital signals, when the patients have the systematic inflamatory respond syndrome we have to find the cause for accuracy treatment, good nutrition, early therapy sepsis effectively reduce the incidence of multiorgan dysfunction mortality.