Treatment of Non-Hodgkin Lymphomas Watch and wait (for indolent, largely asymptomatic lymphomas) Chemotherapy Radiation therapy (most common in patients with limited-stage disease and sometimes in those with advanced-stage disease) Immunotherapy (eg, monoclonal antibodies targeting CD20, CD19, or CD79, or chimeric antigen receptor T cells [CAR T cells]) Targeted drugs (eg, BTK [Bruton tyrosine kinase] inhibitors, PI3K [phosphoinositide 3-kinase] inhibitors, cereblon inhibitors) Sometimes hematopoietic stem cell transplantation (autologous or allogeneic) Treatment varies considerably with cell type, which are too numerous to permit detailed discussion.