Distribution of β-Thalassaemia children according to mutated gene function Gene function Number of patients Ratio (%) Transcriptional mutants Promoter regulatory elements - 28 (A - G) 0 0, 0 10 - 88 (C - T) Mutations in RNA complete processing Connector position IVS 1 - 1 (G - T) IVS 1 - 5 (G - C) IVS 2 - 654 (C - T) 1 1 1, 2 1, 2 RNA translation mutation Nonsense codon CD17 (AAG - TAG) CD26 (GAG - AAG) CD95 (TAC - TAA) - Frameshift CD41/42 (- TTCT) CD71/72 (+A) 84 15 33 2 21 13 97, 6 17, 4 38, 3 2, 4 24, 4 15, 1 Other less common mutations (mutants lose exon 2 through the 95 cd position) 1 1, 2 T o t a l 86 100, 0 Comments: Most of the mutations were related to the RNA translation stage (95.4%).