Table Pancreatic Endocrine Tumors Tumor Hormone Tumor Location Symptoms and Signs ACTHoma ACTH Pancreas Cushing syndrome Gastrinoma Gastrin Pancreas (60%) Duodenum (30%) Other (10%) Abdominal pain, peptic ulcer, diarrhea Glucagonoma Glucagon Pancreas Glucose intolerance, rash, weight loss, anemia GRFoma Growth hormone releasing factor Lung (54%) Pancreas (30%) Jejunum (7%) Other (13%) Acromegaly Insulinoma Insulin Pancreas Fasting hypoglycemia Somatostatinoma Somatostatin Pancreas (56%) Duodenum / jejunum (44%) Glucose intolerance, diarrhea, gallstones Vipoma Vasoactive intestinal peptidase Pancreas (90%) Other (10%) Severe watery diarrhea, hypokalemia, flushing Treatment of Pancreatic Endocrine Tumors Surgical resection Treatment for functioning and nonfunctioning tumors is surgical resection.