Prelabor Rupture of Membranes (PROM) (Premature Rupture of Membranes) By Julie S Moldenhauer, MD, Children's Hospital of Philadelphia Reviewed / Revised Jul 2021 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Guidelines for Managing Prelabor... Prelabor rupture of membranes is leakage of amniotic fluid before onset of labor.