Diseases Caused by Clostridia Diseases caused by clostridia (see table) include Botulism (due to C botulinum) Clostridioides (formerly, Clostridium) difficile-induced colitis Gastroenteritis Soft-tissue infections Tetanus (due to C tetani) Clostridial necrotizing enteritis (due to C perfringens type C) Neutropenic enterocolitis (typhlitis) (due to C septicum) Table The most frequent clostridial infection is minor, self-limited gastroenteritis, typically due to C perfringens type A.