In persistent chronic rhinosinusitis, CT Scan reveals occluded OMC (22/22), opacification of anterior ethmoid sinus (21/22) and posterior ethmoid sinus (12/22), pathology reveals damage of uncinate process, ethmoid tissues with chronic nflammation of mucosa and bone, polyp formation, loss of ciliary. Conclusion: recurrent acute rhinosinusitis due to anatomic variants: damages locate around OMC, infundibulum; in contrast, persistent chronic rhinosinusitis: damages diffuse in all sinuses.