Results: We found that risk of morbidity and mortality closely related to older age  65 (p=0, 01 and p=0.018); ASA >2 (p<0, 001); the delay in operation over 24 hours (p=0, 007); and hole size of perforation (p= 0, 014 and 0, 041). Conclusions: Older age, ASA grade, the delay in operation, and hole size of perforation are factors influencing prognosis of morbidity and mortality after simple closure in patients with perforated peptic ulcer.