Diagnosis of gender dysphoria in adolescents and adults Diagnostic criteria for gender dysphoria in adolescents and adults require ≥ 2 of the following (3): A marked incongruence between one's experienced / expressed gender and primary and / or secondary sex characteristics (or in young adolescents, the anticipated secondary sex characteristics) A strong desire to be rid of (or for young adolescents, prevent the development of) their primary and / or secondary sex characteristics A strong desire for the primary and / or secondary sex characteristics that match their felt gender A strong desire to be the other gender (or some alternative gender different from one's assigned gender) A strong desire to be treated as another gender A strong belief that they have the typical feelings and reactions of another gender The condition must be associated with clinically significant distress or impairment in social, occupational, or other important areas of functioning.