Dyspepsia By Jonathan Gotfried, MD, Lewis Katz School of Medicine at Temple University Reviewed / Revised Jan 2022 | Modified Sep 2022 View Patient Education Etiology Evaluation Treatment Key Points Topic Resources Some Causes of Dyspepsia Some Oral Drugs for Dyspepsia Dyspepsia is a sensation of pain or discomfort in the upper abdomen; it often is recurrent.