Treatment of Langerhans Cell Histiocytosis Supportive care Sometimes hormone replacement therapy for hypopituitarism, most commonly diabetes insipidus Chemotherapy for multisystem involvement, single system multifocal involvement, and involvement in certain sites such as skull-based lesions Sometimes surgery, corticosteroid injection, or rarely, radiation therapy (usually for unifocal bone involvement) General supportive care is essential and may include scrupulous hygiene to limit ear, cutaneous, and dental lesions.