Medications for the Treatment of Gastric Acidity By Nimish Vakil, MD, University of Wisconsin School of Medicine and Public Health Reviewed / Revised Mar 2023 View Patient Education Proton Pump Inhibitors H2 Blockers Antacids Prostaglandins Sucralfate Potassium-Competitive Acid Inhibitors Topic Resources Proton Pump Inhibitors Medications for decreasing acidity are used for peptic ulcer, gastroesophageal reflux disease (GERD), and many forms of gastritis.