Poor prognosis is predicted by the following: CD4 count of < 100 / mcL Age > 35 years Poor functional status Bone marrow involvement History of opportunistic infections High-grade histologic subtype Treatment of non-Hodgkin lymphoma is with various regimens of systemic, multidrug chemotherapy that includes cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide.