Oral antifungals are given as primary prophylaxis or are added if fungal infections occur even once; most useful are Itraconazole orally once a day (100 mg capsule for patients < 13 years or weighing < 50 kg; 200 mg tablet for those ≥ 13 years or weighing > 50 kg) Voriconazole orally every 12 hours (9 mg / kg oral suspension for patients 2 to 12 years or weighing < 40 kg; 200 mg tablet for those weighing ≥ 40 kg) Posaconazole 300 mg delayed-release tablet orally twice a day on day 1, then 300 mg once daily; weight-based dosing for patients weighing < 40 kg Interferon gamma may reduce severity and frequency of infections and is usually included in the treatment regimen.