S - Adenosyl-L-Methionine (SAMe) By Laura Shane-McWhorter, PharmD, University of Utah College of Pharmacy Reviewed / Revised Jan 2023 View Patient Education Claims Evidence Adverse Effects Drug Interactions References More Information S - Adenosyl-L-methionine (SAMe) is a derivative of methionine and a cofactor for multiple synthetic pathways, particularly as a methyl group donor.