Useful drugs include Imipenem 1 g IV every 6 hours Levofloxacin 500 mg IV or orally once / day Clarithromycin 500 mg orally 2 times a day Trimethoprim / sulfamethoxazole 1 double-strength tablet orally 2 times a day Doxycycline 100 to 200 mg orally once / day Cefoxitin 2 g IV every 6 to 8 hours Amikacin 10 to 15 mg / kg IV once / day Combination therapy with at least 2 drugs that have in vitro activity is recommended.