To continue the research, the new chiral derivatives N-heptyl and N-benzyl cis (+); cis (-) - 4 - (3, 4-dimethoxyphenyl) hexahydro phthalazinone were synthesized and determinated the structure. Aims: To continue contributing to the research of the synthesis of new chiral phthalazinone derivatives with selective inhibitory effects on phosphodiesterase IV (PDE4) and strong anti-inflammatory activity, the new chiral derivatives N-heptyl and N-benzyl cis (+); cis (-) - 4 - (3, 4-dimethoxyphenyl) hexahydro phthalazinone were synthesized Objects and Methods: Synthesize new chiral derivatives N-heptyl and N-benzyl cis (+); cis (-) - 4 - (3, 4-dimethoxyphenyl) hexahydro phthalazinone.