Many patients present with an endocrinopathy due to hormone deficiency or excess: Diabetes insipidus if less vasopressin is released because the hypothalamus is compressed Amenorrhea and galactorrhea in women and, less commonly, erectile dysfunction and gynecomastia in men if prolactin is overproduced Gigantism before puberty or acromegaly after puberty if growth hormone is overproduced Cushing syndrome if ACTH is overproduced Sometimes pituitary tumors that compress tissue throughout the anterior lobe of the pituitary reduce production of multiple pituitary hormones, causing generalized hypopituitarism.