Generalized Hypopituitarism By John D Carmichael, MD, Keck School of Medicine of the University of Southern California Reviewed / Revised Apr 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Topic Resources Causes of Hypopituitarism Differentiation of Generalized.. Generalized hypopituitarism refers to endocrine deficiency syndromes due to partial or complete loss of anterior lobe pituitary function.