Serious extraspinal disorders include the following: Abdominal aortic aneurysm Aortic dissection Carotid or vertebral artery dissection Acute meningitis Angina or myocardial infarction Certain gastrointestinal (GI) disorders (eg, cholecystitis, diverticulitis, diverticular abscess, pancreatitis, penetrating peptic ulcer, retrocecal appendicitis) Certain pelvic disorders (eg, ectopic pregnancy, ovarian cancer, salpingitis (see Pelvic Inflammatory Disease (PID)) Certain pulmonary disorders (eg, pleuritis, pneumonia) Certain urinary tract disorders (eg, prostatitis, pyelonephritis, nephrolithiasis) Extraspinal cancer metastases Retroperitoneal inflammatory or infiltrative disorders (eg, retroperitoneal fibrosis, immunoglobulin G4-related disease [IgG4-RD], hematoma, adenopathy) Inflammatory muscle disorders (eg, polymyositis and other inflammatory myopathies, polymyalgia rheumatica) Serious spinal disorders include the following: Infections (eg, diskitis, epidural abscess, osteomyelitis) Primary tumors (of spinal cord or vertebrae) Metastatic vertebral tumors (most often from breasts, lungs, or prostate) Mechanical spine disorders can be serious if they compress the spinal nerve roots or, particularly, the spinal cord.