+ Successful application of Continuous renal replacement therapy on with 3 mode: CVVH, CVVHD and CVVHDF, for 40 patients with acute metabolic crisis decompensation, including 18 patients with severe metabolic acidosis (45%), 12 patients with hyperammonemia (30%) and 9 patients with coma (22.5%) suspected Maple syrup urine diseases (MSUD).