Fulminant Hepatitis By Sonal Kumar, MD, MPH, Weill Cornell Medical College Reviewed / Revised Aug 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Fulminant hepatitis is a rare syndrome of rapid (usually within days or weeks), massive necrosis of liver parenchyma and a decrease in liver size (acute yellow atrophy); it usually occurs after infection with certain hepatitis viruses, alcoholic hepatitis, or drug-induced liver injury (DILI).