The effectiveness in the treatment of moderate and severe psoriasis vulgaris by methotrexate combined with metformin - Comparison in the characteristics of both groups: Table 3.14: Comparison in the characteristics of both group (n = 66) Treatment n (%) Control n (%) p Gender Male 23 (69.7) 16 (48.5) p > 0, 05 (p = 0, 08) Female 10 (30.3) 17 (51.5) Age < 40 5 (15.2) 5 (15.2) p > 0, 05 (p = 0, 856) 40 - 59 17 (51.5) 19 (57.5) ≥ 60 11 (33.3) 9 (27.3) 29 Treatment n (%) Control n (%) p Severity p > 0, 05 (p = 0, 218) Moderate 20 (60.6) 15 (45.5) Severe 13 (39.4) 18 (54.5) - The comparison in treatment results between 2 groups Chart 3.20.