Osteogenesis Imperfecta By Frank Pessler, MD, PhD, Helmholtz Centre for Infection Research Reviewed / Revised Dec 2022 View Patient Education Symptoms and Signs Diagnosis Treatment More Information Topic Resources Osteogenesis Imperfecta... Osteogenesis Imperfecta... Osteogenesis imperfecta is a hereditary collagen disorder causing diffuse abnormal fragility of bone and is sometimes accompanied by sensorineural hearing loss, blue sclerae, dentinogenesis imperfecta, and joint hypermobility.