Diagnosis of Bipolar Disorders Clinical criteria (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels to exclude hyperthyroidism Exclusion of stimulant drug abuse clinically or by blood or urine testing Diagnosis of bipolar disorder is based on identification of symptoms of mania or hypomania as described above, plus a history of remission and relapse.