Gastroenterology 159 (2): 708 - 738.e4, 2020. doi: 10.1053 / j. gastro.2020.05.060 Antimicrobials Empiric antibiotics are generally not recommended except for certain cases of traveler's diarrhea or when suspicion of Shigella or Campylobacter infection is high (eg, contact with a known case).