Evaluation were checked with a survey of hematology and quantification of hepatic MDA and GSH. Results: The aqueous extract of Polygonum multiflorum tended to reduce concentration of MDA and increased concentration of GSH in mouse liver, but not statistically significant. The aqueous extract combined Polygonum multiflorum and Sesamum indicum nigrum reduced significantly concentration of MDA and increased significantly concentration of GSH in rat liver.