Heart 86 (6): 666 - 671, 2001. doi: 10.1136 / heart.86.6.666 Treatment of Non-Compaction Cardiomyopathy Moderation of physical activity Sometimes an implantable cardioverter-defibrillator (ICD) Usually a beta-blocker Sometimes other antiarrhythmic drugs (particularly sotalol or amiodarone) Heart failure therapy (including transplantation) as required Sometimes chronic anticoagulation Patients with non-compaction cardiomyopathy should avoid athletic exertion because such activities foster life-threatening arrhythmias.