Langerhans Cell Histiocytosis By Jeffrey M Lipton, MD, PhD, Zucker School of Medicine at Hofstra / Northwell; Carolyn Fein Levy, MD, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell Reviewed / Revised Dec 2021 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Histiocytosis Juvenile Xanthogranuloma Eosinophilic Granuloma of... Histiocytosis (Head CT) Histiocytosis (Pelvic Bone) Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely.