Macrolides By Brian J Werth, PharmD, University of Washington School of Pharmacy Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Pharmacokinetics Indications Contraindications Use During Pregnancy and Breastfeeding Adverse Effects Dosing Considerations Topic Resources QT Interval Correction (EKG) Mechanisms of Action: Protein... Macrolides Some Clinical Uses of Macrolides Macrolides are antibiotics that are primarily bacteriostatic; by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis.