DEN2 infection manifested more severely and more frequently than DEN1 in terms of shock (p < 0.001), reshock (p=0.011), respiratory distress (p=0.037), hepatomegaly (p=0.033), hypoalbuminemia (p=0.006), ascites (p=0.012), pleural effusions (p < 0.001) and oxygen support (p=0.037).