Treatment of Simple Nontoxic Goiter Depends on cause In iodine-deficient areas, the following eliminate iodine deficiency: Iodine supplementation of salt Oral administration of iodized oil Intramuscular administration of iodized oil yearly Iodination of water, crops, or animal fodder Goitrogens (eg, cassava, broccoli, cauliflower, cabbage) being ingested should be stopped.