Chronic Myeloid Leukemia (CML) (Chronic Granulocytic Leukemia; Chronic Myelocytic Leukemia; Chronic Myelogenous Leukemia) By Ashkan Emadi, MD, PhD, University of Maryland; Jennie York Law, MD, University of Maryland, School of Medicine Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Chronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes.