Haematologica 103: 1433 - 1443, 2018. doi: 10.3324 / haematol.2018.193003 Symptoms and Signs of Hereditary Hemorrhagic Telangiectasia The most characteristic lesions of hereditary hemorrhagic telangiectasia are small red-to-violet telangiectatic lesions on the face, lips, oral and nasal mucosa, and tips of the fingers and toes.