Hypertrophic Cardiomyopathy By Tisha Suboc, MD, Rush University Reviewed / Revised Nov 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Hypertrophic Cardiomyopathy... Hypertrophic Cardiomyopathy... Hypertrophic cardiomyopathy is a congenital or acquired disorder characterized by marked ventricular hypertrophy with diastolic dysfunction (eg, due to valvular aortic stenosis, coarctation of the aorta, systemic hypertension).