Local compression by tumor masses often causes symptoms and signs, including Jaundice secondary to intrahepatic or extrahepatic bile duct obstruction Localized edema (lymphedema) secondary to lymphatic obstruction by the tumor Severe dyspnea and wheezing secondary to tracheobronchial compression due to mediastinal disease Dyspnea, cough, and / or chest discomfort due to infiltration of lung parenchyma, which may simulate lobar consolidation or bronchopneumonia Epidural invasion that compresses the spinal cord may result in paraplegia.