They include Inherited noninflammatory connective tissue disorders (eg, Ehlers-Danlos syndrome or Marfan syndrome) Vascular infections (tuberculous, fungal, or syphilitic) Fibromuscular dysplasias Disorders causing arterial thrombosis (eg, hypercoagulable states) Idiopathic inflammatory conditions (eg, ankylosing spondylitis with aortitis, rheumatoid arthritis, Cogan syndrome or Behçet syndrome, Kawasaki disease, sarcoidosis) All of these disorders can affect large vessels.