Patients who are not White may have HLA polymorphisms that are different from those of donors who are White, a higher rate of presensitization to HLA antigens, and a higher incidence of blood types O and B. Infection Donor and recipient exposure to common infectious pathogens and active as well as latent infections must be detected before transplantation to minimize risk of transmitting infection from the donor and risk of worsening or reactivating existing infection in the recipient (due to use of immunosuppressants).