Results: The expression of p53 was 34.1% in the total specimens, in which p53 (1 +) was 17.1%, p53 (2 +) was 4.8%, p53 (3 +) was 12.2% and negative p53 was 65.9%. Malignancies of the nose and paranasal sinuses have many kinds of histopathology: cancer of nerve cell, diffuse B cell lymphoma, sarcoma, adenoid cystic carcinoma and undifferentiated adenocarcinomas.