Front Immunol 8: 1018, 2017. doi: 10.3389 / fimmu.2017.01018 Treatment Sometimes glucocorticoids, cimetidine, and / or tonsillectomy Treatment of PFAPA syndrome is optional and depends on the frequency and severity of flare-ups; it can include glucocorticoids, such as a single dose of prednisone (1 to 2 mg / kg orally) or betamethasone (0.1 to 0.2 mg / kg), which, when given at the onset of an episode can dramatically abort fever attacks in a few hours, cimetidine (20 to 40 mg / kg orally once a day), and, rarely, tonsillectomy.