Level of proinflammatory cytokines in blood such as TNF, IL1b, IL6 have been rising at the beginning of CVVH and falling at 12, 24 hours, showing that CVVH improved organ impairment and elimination of these inflammatory mediators Conclusion: the study revealed the role of proinflammatory cytokines as a basis for CVVH on treatment of bee sting with early complications of shock, ARDS as well as late complications of renal failure, hepatic failure, reducing mortality and saving many patients with bee sting complicated with MODS.