Once in the lungs, infection may Remain localized in the lungs Disseminate hematogenously Hematogenous dissemination can cause focal infection in numerous organs, including the skin, prostate, epididymides, testes, seminal vesicles, kidneys, vertebrae, ends of long bones, subcutaneous tissues, central nervous system, oral or nasal mucosa, thyroid, lymph nodes, and bone marrow.