rheumatoid arthritis patients with increased IL-1α concentrations is accounted for 40, 8%; increased IL-1β concentration in 48.7%; increased IL-2 concentration in 32, 9%; increased IL-4 concentration in 86%; increased IL-6 concentration in 100%; increased IL-8 concentration in 39, 5%; increased IL-10 concentration in 81, 6%; increased VEGF concentration in 51, 3%; increased IFN-γ concentration in 67, 1%; increased TNF-α concentration in 61, 8%; increased MCP1 concentration in 30, 3%; increased EGF concentration in 39, 43%.