Subject and method: 18F-NaF, using a synthetic chemical process 18F-NaF at laboratory scale not exceeding 100mCi / batch. Synthesis formula: 1000 ± 100mCi 18F-NaF/15ml, NaCl 0.9%: 15ml; bombardment energy: 18MeV; Beam intensity 35 - 36.5µA, 30 minutes of bombardment; radioactive chemistry: NaCl 0.9%: 3ml; Water: 5ml; Synthesis time 15 minutes; adding 12ml of 0.9% NaCl to the final product vial.