Compare results between before antibiotic treatment and after 48h antibiotic treatment group 1: TBC1 - 2 = 2.867 PBC1 - 2 < 0.009 (There is a difference (P < 0.05); TCRP1 - 2 = 3.544 PCRP1 - 2 = 0.002 (There is a difference (P < 0.05); TPCT1 - 2 =2.261; PPCT1 - 2 = 0.034 (There is a difference (P < 0.05).