Review of systems should seek symptoms of causative disorders, including Irritability, sweating, weight loss, and palpitations (hyperthyroidism) Depression, dry skin, and weight gain (hypothyroidism) Headache, pica, hair thinning, and exercise intolerance (iron deficiency anemia) Constitutional symptoms of weight loss, fatigue, and night sweats (cancer) Intermittent weakness, numbness, tingling, and visual disturbances or loss (multiple sclerosis) Steatorrhea, jaundice, and right upper quadrant pain (cholestasis) Urinary frequency, excessive thirst, and weight loss (diabetes) Past medical history should identify known causative disorders (eg, renal disease, cholestatic disorder, cancer being treated with chemotherapy) and the patient's emotional state.