Crude extract from fermentation liquid of strain C21 can inhibit Enterococcus faecalis CCARM 5168 at a concentration of 16 µg / ml, 8 µg / ml for E faecalis CCARM 5171, 32 µg / ml for E faecalis CCARM 5024, 64 µg / ml for E faecium CCARM 5025, 32 µg / ml for Streptococcus agalactiae CCARM 4504, and 8 µg / ml for S pyogenes CCARM 4520.