Treatment of PDA Supportive medical therapy In symptomatic preterm infants, cyclo-oxygenase (COX) inhibitor therapy (eg, indomethacin, ibuprofen lysine) Sometimes transcatheter closure or surgical repair Typical medical management of patent ductus arteriosus includes fluid restriction, a diuretic (usually a thiazide), maintenance of hematocrit ≥ 35%, providing a neutral thermal environment, and, for ventilated patients, use of positive end-expiratory pressure (PEEP) to improve gas exchange.