Preliminary studies in VN-ese patients had cited the high rate of mutation on different stage of the diseases. Objective: To define the rate of precore (PC) and basal core promoter (BCP) in CHB patients with HBeAg (+) or HBeAg (+). Methods: This prospective observational study was done from December 08 to April 09 on CHB patients at the outpatient and the inpatient wards.