Aim: Comparing MNV to procalcitolin in sepsis and non-sepsis would determinate MNV value in order to orient the early prediction of sepsis. Objectives: Among the 94 patients, there were 41 non-sepsis patients and 48 sepsis patients with infection degrees from mild to severe in the various departments of Chợ Rẫy Hospital for the period 3 months from May 2011 to July 2011.Method: Perspective study. Results anhd Conclusion: In the first group (non-sepsis with procalcitonin less than 0.5), MNV was 150.6 ± 1.5.