There have not been many studies of IE in Viet Nam for recent decades. Objectives: survey etiologic agents and empiric therapeutic antibiotics in IE at Cho Ray Hospital. Methods: a retrospective, cross-sectional and descriptive study on patients with IE who were admitted to Department of Cardiology, Cho Ray Hospital from 1/2000 to 12/2009.Results: In ten years (2000 - 2009), there were 225 hospitalized patients with IE.