Treatment of Obesity Dietary management Physical activity Behavioral interventions Drugs (eg, phentermine, orlistat, lorcaserin [not available in US because of possible cancer risk], phentermine / topiramate, naltrexone / bupropion extended-release, liraglutide, semaglutide) Bariatric surgery Weight loss of even 5 to 10% improves overall health, helps reduce risk of developing cardiovascular complications (eg, hypertension, dyslipidemia, insulinresistance) and helps lessen their severity, and may lessen the severity of other complications and comorbid disorders such as obstructive sleep apnea, fatty liver, infertility, and depression.