Direct Vasodilators for Hypertens... Oral Diuretics for Hypertension A number of drug classes are effective for initial and subsequent management of hypertension: Adrenergic modifiers Angiotensin-converting enzyme (ACE) inhibitors Angiotensin IIreceptor blockers (ARBs) Beta-blockers Calcium channel blockers Direct renin inhibitors Direct vasodilators Diuretics Selection and use of medications in the treatment of stable hypertension is discussed elsewhere.