- AFP-L3 and PIVKA-II values increased above the normal limit in the group of HCC patients with tumors < 2 cm, accounting for 78.9% and 63.2%, respectively; in the group with tumor size from 2 to 5 cm were 66.7% and 93.8% and in the group with tumor size > 5 cm were 84.2% and 94.7%, respectively.