Research Objective: Using AIMS evaluation scale clinica tardive dyskinesia by using classical neuroleptics prolonged in patients with schizophrenia treated with Clozapine combined with Vitamin E Objects and methods of research: a double-blind study with tardive dyskinesia on schizophrenic patients in Hai Phong Psychiatric Hospital from July 2012 to May 03 2014, divided into 2 groups: Group 1: 30 patients treated with clozapine combined with Vitamin E, Group 2 included 33 patients treated with clozapine alone.