Per the KDIGO (Kidney Disease: Improving Global Outcomes) Clinical Practice Guideline for Acute Kidney Injury (1), AKI is defined as any of the following: Increase in the serum creatinine value of ≥ 0.3 mg / dL (26.52 micromol / L) in 48 hours Increase in serum creatinine of ≥ 1.5 times baseline within the prior 7 days Urine volume < 0.5 mL / kg / hour for 6 hours Evaluation should determine the presence and type of AKI and seek a cause.