Marfan Syndrome By Frank Pessler, MD, PhD, Helmholtz Centre for Infection Research Reviewed / Revised Dec 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Marfan Syndrome Marfan Syndrome (Musculoskeletal... Marfan Syndrome (Thumb Sign) Marfan Syndrome (Long Fingers) Marfan syndrome consists of connective tissue anomalies resulting in ocular, skeletal, and cardiovascular abnormalities (eg, dilation of ascending aorta, which can lead to aortic dissection).