Primary Infantile Glaucoma (Infantile Glaucoma; Congenital Glaucoma; Buphthalmos) By Leila M Khazaeni, MD, Loma Linda University School of Medicine Reviewed / Revised Feb 2022 | Modified Sep 2022 View Patient Education Topic Resources Aqueous humor production... Primary infantile glaucoma is a rare developmental defect in the iridocorneal filtration angle of the anterior chamber that prevents aqueous fluid from properly draining from the eye.