Nirmatrelvir, an oral antiviral drug, given in combination with ritonavir, received Emergency Use Authorization (EUA) from the US Food and Drug Administration (FDA) for treatment of mild to moderate COVID-19 in adults and adolescents (≥ 12 years of age weighing ≥ 40 kilograms) who have positive results of direct SARS-CoV-2 viral testing and who are at high risk for progression to severe COVID-19.