Some autoimmune disorders are linked to specific HLA alleles—for example, Ankylosing spondylitis and reactive arthritis to HLA-B27 Multiple sclerosis to HLA-DR2 Narcolepsy to HLA-DR2 and HLA-DQB1 * 06: 02 Psoriasis to HLA-C * 06: 02 Rheumatoid arthritis to HLA-DR4 Type 1 diabetes mellitus to HLA-DQ2 and HLA-DQ8