Immunosuppression A common 3-drug posttransplant immunosuppression regimen combines A calcineurin inhibitor (cyclosporine or tacrolimus) A purine metabolism inhibitor (azathioprine or mycophenolate) Methylprednisolone or another corticosteroid First, patients are given high doses perioperatively; methylprednisolone IV is often given intraoperatively before reperfusion of the transplanted lung.