By using the Elevated Plus Maze model, swimming mice test and dark / light test, we evaluated the anti-depressant effect of Panax vietnamensis on mice and the obtained results revealed that the crude extract at 200 mg / kg showed markedly anxiolytic, anti-stress effects related to anti-depessant activity on the basis of both increasing the frequency and time of mice in the light compartment in the Dark / Light test and swimming time in the swimming capacity test.