Overview of Generalized Anxiety Disorder VIDEO Treatment of Generalized Anxiety Disorder Antidepressants and often benzodiazepines Certain antidepressants, including selective serotonin reuptake inhibitors (SSRIs; eg, escitalopram, starting dose of 10 mg orally once a day) and serotonin-norepinephrinereuptake inhibitors (SNRIs; eg, venlafaxine extended-release, starting dose 37.5 mg orally once a day) are effective but typically only after being taken for at least a few weeks.