Patients more often have Angioedema, skin abnormalities, or both Circulating immune complexes (sometimes with serum sickness) Hypergammaglobulinemia (especially high IgE) Patients with the lymphoproliferative variant also more often respond favorably to corticosteroids and occasionally develop T-cell lymphoma. Other hypereosinophilic syndrome variants include Gleich syndrome (cyclical eosinophilia and angioedema), familial hypereosinophilic syndrome mapped to 5q 31 - 33, and other organ-specific syndromes.