The intervention group was treated the same as the control group and adding Bio-acimin Gold include: Lactobacillus; Bacillus subtilis; Streptococcus faecalis; DHA; Coenzyme Q10; Beta Glucan; Immune gamma, zinc, calcium, selenium and vitamin B group. Indicators are monitored before treatment (T0) and after treatment (T2) are weight, height, serum zinc levels, hemoglobin and serum Immuno-globulin A concentrations (IgA), gastrointestinal symptoms and dietary intake.