Neonatal Cholestasis By William J Cochran, MD, Geisinger Clinic Reviewed / Revised Aug 2021 | Modified Sep 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Diagnostic Evaluation for... Overview of Biliary Atresia Cholestasis is failure of bilirubin secretion, resulting in conjugated hyperbilirubinemia and jaundice.