- Local failure seemed appear early when there was the presence of: Full thickness penetration of rectal wall (T3, T4, 35 ± 6 months; p=0, 0554), Regional lymph node involvement (19 ± 4 months vs 47 ± 4 months; p=0, 0637), High grade tumor (12 months vs 45 ± 4 months; p=0, 0493).