Testing includes Amniocentesis or chorionic villus sampling Quad screen Ultrasonography Maternal serum alpha-fetoprotein Noninvasive prenatal screening Amniocentesis or chorionic villus sampling may detect inherited metabolic and chromosomal disorders, carrier states, and CNS malformations (eg, neural tube defects, anencephaly) and may be considered for all pregnant women > 35 years of age because their risk of having an infant with Down syndrome is increased and for pregnant women with a family history of inherited metabolic disorders.