Alport Syndrome (Hereditary Nephritis) By Frank O'Brien, MD, Washington University in St Louis Reviewed / Revised Jun 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Alport Syndrome (Hereditary... Alport syndrome is a genetically heterogeneous disorder characterized by nephritic syndrome (ie, hematuria, proteinuria, hypertension, eventual renal insufficiency) often with sensorineural deafness and, less commonly, ophthalmologic symptoms.