Treatment of Neonatal Hyperglycemia Reduction of IV dextrose concentration, rate, or both Sometimes IV insulin Treatment of iatrogenic hyperglycemia is reduction of the IV dextrose concentration (eg, from 10% to 5%) or of the infusion rate; hyperglycemia persisting at low dextrose infusion rates (eg, 4 mg / kg / minute) may indicate relative insulin deficiency or insulin resistance.