Drug therapy is recommended for children > 8 years and with either of the following: Poor response to dietary therapy, LDL-C ≥ 190 mg / dL (≥ 4.9 mmol / L), and no family history of premature cardiovascular disease LDL-C ≥ 160 mg / dL (≥ 4.13 mmol / L) and a family history of premature cardiovascular disease or ≥ 2 risk factors for premature cardiovascular disease Medications used in children include many of the statins.