The results showed that RFA was an effective procedure for treating inoperable NSCLC. Specifically, 36.5% of cases had complete necrosis after RFA, the median survival time was 20.5 months, and the overall survival rates after 1 year, 3 years, and 5 years were 57.1%, 16.8%, and 6.3%, respectively. The median local progression-free survival was 15.7 months, and the local progression-free survival rates after 1 year, 3 years, and 5 years were 42.9%, 9.5%, and 6.3%, respectively.