However, in recent years, the increasing prevalence of oral pathogens resistance is having a negative impact on the efficacy of antibiotics treatment. Objectives: To define the main pathogenic bacteria involved in orofacial odontogenic infections and their susceptibility to commonly used antibiotics. Materials and methods: The study was conducted at Can Tho General Hospital and Hospital of Ophthalmology and Odonto-Maxillo-facial Surgery from 9/2009 to 3/2010.