Objectives: To characterize the epidemiological, clinical, laboratory and therapeutic features of patients with systemic onset juvenile rheumatoid arthritis (SoJRA). Method: A case-series study of 27 patients with systemic onset juvenile rheumatoid arthritis (SoJRA) was admitted to the Children's Hospital 2, HCMC from 1/2003 to 7/2009.Results: Study has shown the predominance in females (female to male ratio is 1.5: 1).