Outpatient treatment with oral antibiotics is possible if all of the following criteria are satisfied: Patients are expected to be adherent Patients are immunocompetent Patients have no nausea or vomiting or evidence of volume depletion or septicemia Patients have no factors suggesting complicated UTI Ciprofloxacin 500 mg orally twice a day for 7 days and levofloxacin 750 mg orally once a day for 5 days are 1st-line antibiotics if < 10% of the uropathogens in the community are resistant.