Membranoproliferative Glomerulonephritis (Mesangiocapillary Glomerulonephritis; Lobular Glomerulonephritis) By Frank O'Brien, MD, Washington University in St Louis Reviewed / Revised Jun 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Prognosis More Information Key Points Topic Resources Membranoproliferative Glomerulone... Membranoproliferative Glomerulone... Serum Complement Profiles... Overview of Membranoproliferative... Membranoproliferative glomerulonephritis (MPGN) is characterized by a pattern of glomerular injury on light microscopy, including hypercellularity and thickening of the glomerular basement membrane.