Hirschsprung Disease (Congenital Megacolon) By William J Cochran, MD, Geisinger Clinic Reviewed / Revised Apr 2021 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Hirschsprung Enterocolitis (Toxic Megacolon) Topic Resources Single-Contrast Barium Enema... Hirschsprung Disease Overview of Hirschsprung... Hirschsprung disease is a congenital anomaly of innervation of the lower intestine, usually limited to the colon, resulting in partial or total functional obstruction.