The change of plasma IL-10 concentration Cytokine Times IL-10, median (25th - 75th), n=31 Friedman Test T1 21.9 (7.88 - 51.4) χ2 = 13.311 p = 0.004 (<0.05) T2 12.5 (7.33 - 33.06) T3 9.38 (4.73 - 31.78) T4 9.15 (3.36 - 25.76) Comment: The median value of the IL-10 concentration tends to decrease gradually during continuous hemofiltration, this difference is statistically significant.