Gonadal dysgenesis due to genetic or chromosomal abnormalities (which can cause primary ovarian insufficiency) include Turner syndrome 46, XY gonadal dysgenesis Anatomic causes of amenorrhea include Congenital female reproductive tract anomalies (eg, vaginal agenesis, imperforate hymen) Acquired abnormalities (eg, Asherman syndrome or cervical stenosis) Common endocrinologic causes include Constitutional delay of puberty Pregnancy (the most common cause in women of reproductive age) Polycystic ovary syndrome Hyperprolactinemia (eg, due to pituitary adenoma, lactational amenorrhea during breastfeeding, or use of antipsychotics) Functional hypothalamic amenorrhea (eg, due to excessive exercise, eating disorders, or stress [1]) Primary ovarian insufficiency (premature ovarian failure) Hormonal medications (eg, oral contraceptives, depot medroxyprogesterone) Progestin-only contraceptives often cause amenorrhea.