Esophageal Rupture By Kristle Lee Lynch, MD, Perelman School of Medicine at The University of Pennsylvania Reviewed / Revised Mar 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Topic Resources Esophagography with Water-Soluble... Esophageal rupture may be iatrogenic during endoscopic procedures or other instrumentation or may be spontaneous (Boerhaave syndrome).