Cytokine serum levels in the study group and control group before the treatment Cytokine Study group (n=35) (X±SD) Control group (n=35) (X±SD) p IL-2 (pg / ml) 86, 259 ± 70, 50 5, 000 ± 0, 000 <0, 001 IL-4 (pg / ml) 8, 041 ± 9, 646 3, 829 ± 5, 541 <0, 01 IL-6 (pg / ml) 16, 687 ± 79, 244 3, 084 ± 6, 413 >0, 05 IL-8 (pg / ml) 53, 024 ± 228, 239 25, 264 ± 66, 821 <0, 05 IL-10 (pg / ml) 1, 984 ± 2, 113 1, 000 ± 0, 000 <0, 05 IL-17 (pg / ml) 1, 798 ± 2, 062 2, 000 ± 0, 000 <0, 001 TNF-α (pg / ml) 3, 438 ± 11, 090 1, 715 ± 1, 371 >0, 05 INF - (pg / ml) 8, 311 ± 3, 214 9, 099 ± 2, 894 >0, 05 Conclusion: Compared with the control group, psoriatic patients had significantly different serum concentrations of several cytokines (IL-2, IL-4, IL-8, IL-10).