Targets include Plateau alveolar pressures 30 cm H2O (factors that potentially decrease chest wall and abdominal compliance considered) Tidal volume 6 mL / kg ideal body weight to minimize further lung injury FIO2 as low as is allowed to maintain adequate oxygen saturation to minimize possible oxygen toxicity PEEP should be high enough to maintain open alveoli and minimize FIO2 until a plateau pressure of 28 to 30 cm H2O is reached.