Aims of study: The aim of study focused on determining hypoglycemic and hepatorenal protective effects of herbal formula from Gymnema sylvestre, Gynostemma pentaphyllum, Evodia lepta, Ophiopogon japonicus, Schisandra chinensis, and Astragalus membranaceus (Thanh Duong An capsules) on glucose tolerance test and streptozotocin-induced diabetes in mice.