Complications In addition to respiratory disease that can progress to acute respiratory distress syndrome (ARDS) and death, other serious complications include the following: Heart disorders including arrhythmias, cardiomyopathy, and acute cardiac injury Coagulation disorders including thromboembolism and pulmonary emboli, disseminated intravascular coagulation (DIC), hemorrhage, and arterial clot formation Guillain-Barré syndrome (rare) Sepsis, shock, and multiorgan failure A postinfectious inflammatory syndrome termed multisystem inflammatory syndrome in children (MIS-C) has been observed as a rare complication of SARS-CoV-2 infection.