Among them, the disease group consists of 56 patients (12 male, 44 female, mean age 52.5 ± 27.5 years) were diagnosed as rheumatoid arthritis according to ARA and ACR / EULAR 2010 criteria; the non-rheumatoid arthritis group includes 45 persons (11 male, 34 female, mean age 47.2 ± 18.0 years).