Review of systems should ask about symptoms that suggest an organic cause, including new onset of poor suck, hypotonia, and ingestion of honey before age 12 months (infantile botulism); cold intolerance, dry skin, fatigue, hypotonia, prolonged neonatal hyperbilirubinemia, urinary frequency, and excessive thirst (endocrinopathies); change in gait, pain or weakness in lower extremities, and urinary incontinence (spinal cord defects); night sweats, fever, and weight loss (cancer); and vomiting, abdominal pain, poor growth, and intermittent diarrhea (intestinal disorders).