Drugs that potentially decrease libido include weak androgen receptor antagonists (eg, spironolactone, cimetidine), luteinizing hormone-releasing hormone agonists (eg, leuprolide, goserelin, buserelin) and antagonists (eg, degarelix) used to treat prostate cancer, antiandrogens used to treat prostate cancer (eg, flutamide, bicalutamide), 5-alpha-reductase inhibitors (eg, finasteride, dutasteride) used to treat benign prostatic hyperplasia, some antihypertensives, and virtually all drugs that are active in the central nervous system (eg, selective serotonin reuptake inhibitors [SSRIs], tricyclic antidepressants, antipsychotics).