Different classes of drugs contribute to different types of dry eye, as in the following examples: Aqueous tear-deficient dry eyes: Diuretics, anticholinergics, antidepressants, beta-blockers, decongestants, oral contraceptives Evaporative dry eyes: Isotretinoin, antiandrogens Dry eyes due to poor eyelid closure: Major antipsychotics, adrenergic agonists, botulinum toxin injections Symptoms and Signs of Keratoconjunctivitis Sicca Patients report itching; burning; a gritty, pulling, or foreign body sensation; or photosensitivity.