Plague and Other Yersinia Infections (Bubonic Plague; Pestis; Black Death) By Larry M Bush, MD, FACP, Charles E Schmidt College of Medicine, Florida Atlantic University; Maria T Vazquez-Pertejo, MD, FACP, Wellington Regional Medical Center Reviewed / Revised Apr 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Prevention Key Points More Information Other Yersinia Infections Topic Resources Plague Bubo (Femoral) Plague Bubo (Inguinal) Plague Bubo (Axillary) Pneumonic Plague Plague is caused by the gram-negative bacterium Yersinia pestis.