Nonsolar lentigines are sometimes associated with systemic disorders, such as Peutz-Jeghers syndrome (in which profuse lentigines of the lips occur), multiple lentigines syndrome (or LEOPARD syndrome, which stands for multiple L entigines, E lectrocardiogram [ECG] conduction abnormalities, O cular hypertelorism, P ulmonic stenosis, A bnormal genitals, R etardation of growth, and sensorineural D eafness), or xeroderma pigmentosum.