Contraindications and Precautions of Tetanus-Diphtheria Vaccine The main contraindication for Td is A severe allergic reaction (eg, anaphylaxis) after a previous dose or to a vaccine component Precautions with Td include Guillain-Barré syndrome within 6 weeks after a previous dose of a vaccine that contains tetanus toxoid Moderate or severe acute illness with or without fever History of type III hypersensitivity reactions after a previous dose of a vaccine that contains tetanus or diphtheria toxoid (vaccination is postponed until ≥ 10 years since the last dose of a vaccine that contains tetanus toxoid) Dose and Administration of Tetanus-Diphtheria Vaccine The Td dose is 0.5 mL IM.