Adrenal gland disorders can develop when: your pituitary gland fails to control your hormone production properly benign, or noncancerous, tumors grow in your adrenal glands malignant, or cancerous, tumors grow in your adrenal glands infections develop in your adrenal glands you inherit certain genetic mutations These disorders include the following medical conditions: Addison's disease: This rare autoimmune disease develops when your adrenal glands don't produce enough cortisol or aldosterone.