Autosomal Dominant Polycystic Kidney Disease (ADPKD) By Enrica Fung, MD, MPH, Loma Linda University School of Medicine Reviewed / Revised Apr 2023 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Prognosis Key Points Topic Resources Polycystic Kidney Disease CT Axial View of Polycystic... Polycystic kidney disease (PKD) is a hereditary disorder of renal cyst formation causing gradual enlargement of both kidneys, sometimes with progression to renal failure.