Treatment of Vasculitis Induction of remission for life-threatening or organ-threatening vasculitis with corticosteroids, often with cyclophosphamide or rituximab Induction of remission for less severe vasculitis with corticosteroids plus a less potent immunosuppressant (eg, methotrexate, azathioprine, mycophenolate mofetil) or rituximab Maintenance of remission with methotrexate, azathioprine, or rituximab, plus tapering of corticosteroids Treatment of vasculitis depends on the etiology, the type of vasculitis, and extent and severity of disease.