Symptoms and Signs of POEMS Syndrome Patients may have the following: Adrenal insufficiency (Addison disease) Diabetes mellitus type 2 Hepatomegaly Hyperparathyroidism Hypogonadism Lymphadenopathy Monoclonal gammopathy Osteoclastic bone lesions Polyneuropathy (peripheral motor and sensory manifestations) Primary hypothyroidism Skin abnormalities (eg, hyperpigmentation, dermal thickening, hirsutism, angiomas, hypertrichosis) Other symptoms and signs of POEMS syndrome may include edema, ascites, pleural effusion, papilledema, and fever.