Br J Clin Pharmacol 83 (8): 1801 - 1807, 2017. doi: 10.1111 / bcp.13256 Epub 2017 Mar 2 Symptoms and Signs of SIADH Symptoms of SIADH are those of hyponatremia, which mainly involve central nervous system dysfunction and generally occur when the effective plasma osmolality falls to < 240 mOsm / kg (< 240 mmol/kg).