Amphetamines (Methamphetamine) By Gerald F O'Malley, DO, Grand Strand Regional Medical Center; Rika O'Malley, MD, Grand Strand Medical Center Reviewed / Revised Dec 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Treatment More Information Amphetamines are sympathomimetic drugs with central nervous system stimulant and euphoriant properties whose toxic adverse effects include delirium, hypertension, seizures, and hyperthermia (which can cause rhabdomyolysis and renal failure).