Low doses include 0.3 mg orally once a day (conjugated equine or synthetic estrogens) 0.5 mg orally once a day (oral estradiol) 0.025 to 0.375 mg a day released by a patch applied to the skin once or twice a week (estradiol patch) Women who have a uterus should be given a progestogen in addition to estrogen because unopposed estrogen increases risk of endometrial cancer.