After dividing case group into 2 subgroups, we found the significant DNA hypomethylation at CpG-2.3.4, CpG-5, CpG-9, CpG-10, CpG-11, CpG-12.13, CpG-17, CpG-18.19 in subgroup CASES-F-P compared to CASES-NON-F-P also control group (p< 0.05).