Indications for Lipoglycopeptides Lipoglycopeptides are broadly active against gram-positive bacteria, including Streptococci Enterococcus faecalis Enterococcus faecium Staphylococcus aureus, including S aureus that is methicillin-resistant or vancomycin - intermediate-resistant Oritavancin is active against vancomycin - resistant enterococci (VRE) strains that harbor the vanA gene; dalbavancin and telavancin are not.