Conclusion: Extracts from Prunella vulgaris L are potential antiherpetic agents as herbal products. Abbreviation: CC, cytotoxic concentration; CC50, 50% cytotoxic concentration; CPE, cytopathic effect; IC50, 50% Inhibitory concentration; HSV, Herpes simplex virus; SI, selectivity index, TCID50, 50% tissue culture infectious dose.