For progressive cases unresponsive to standard drugs, combinations of 4 to 6 drugs that include clarithromycin 500 mg orally 2 times a day or azithromycin 600 mg orally once / day, rifabutin 300 mg orally once / day, ciprofloxacin 250 to 500 mg orally or IV 2 times a day, clofazimine 100 to 200 mg orally once / day, and amikacin 10 to 15 mg / kg IV once / day may be tried.