These high-risk groups include Men who have sex with men People with a sexually transmitted infection People who have had > 1 sex partner during the previous 6 months Health care and public safety workers potentially exposed to blood or other infectious body fluids People who currently or have recently injected illicit drugs People who have diabetes and are < 60 years old (or ≥ 60 years if their risk of acquiring HBV is considered increased) People with end-stage renal disease who receive dialysis, HIV infection, or chronic liver disease, or hepatitis C Household contacts and sex partners of people who are HBsAg-positive Clients and staff members of institutions and nonresidential day care facilities for people with developmental disabilities People in correctional facilities or facilities providing services to injection-drug users International travelers to regions with high or intermediate HBV endemicity Postexposure prophylaxis Hepatitis B postexposure immunoprophylaxis combines vaccination with hepatitis B immune globulin (HBIG), a product with high titers of anti-HBs.