Patients who require treatment regardless of chest x-ray stage include those with the following: Worsening symptoms Limitation of activity Markedly abnormal or deteriorating lung functions Worrisome x-ray changes (eg, cavitation, fibrosis, conglomerate masses, signs of pulmonary hypertension) Heart, nervous system, or eye involvement Renal or hepatic failure Moderate to severe hypercalcemia Disfiguring skin (eg, lupus pernio) or joint disease NSAIDs) are used to treat musculoskeletal discomfort.