APTT longer than 72 seconds [adjusted odds ratio (aOR) 7.10, 95% CI 2.60 - 19.50, p <0.001], fibrinogen below 2 g / L [aOR 7.10, 95% CI 2.60 - 19.50, p <0.001] and ACT longer than 220 seconds [aOR 3.9, 95% CI 1.20 - 11.80, p=0.017] on prior major bleeding days were independently associated with greater risk of bleeding occurrence.