Obstet Gynecol 117 (4): 837 - 843 2011. doi: 10.1097/AOG.0b013e3182113c10 Treatment of Ectopic Pregnancy Usually, methotrexate for small, unruptured ectopic pregnancies Surgical resection if rupture is suspected or criteria are not met for methotrexate treatment Rho (D) immune globulin if the woman is Rh-negative Methotrexate Patients with a tubal pregnancy may be treated with methotrexate if all of the following are present: The patient is hemodynamically stable with no signs of current or impending rupture.