In the model of granuloma formation following implantation cotton pellets in mice: The level of weight loss of dry granulomas in all 6 groups was statistically significant compared with the control group; the M1 group, the NTL1 group and the PH1 group of weight reduction were similar; the meloxicam 4mg / kg (M2) group, the NTL2 group and the PH2 group had similar dry granuloma weight reduction.