To evaluate the Health-related quality of life (HRQOL) of patients following minimally invasive open-heart surgery with endoscopic support for mitral valve replacement at the Cardiovascular Center of E Hospital. 6 Subjects and methods: A cross-sectional descriptive study on 46 cases following minimally invasive open-heart surgery with endoscopic support for mitral valve replacement at Cardiovascular Center of Hospital E from 1/1/2021 to 31 / 21/2021, using the SF-36 questionnaire.