Adverse Effects of Tetracyclines Adverse effects of tetracyclines include Gastrointestinal disturbances Clostridioides (formerly Clostridium) difficile-induced diarrhea (pseudomembranous colitis) Candidiasis Photosensitivity Bone and dental effects in children Fatty liver Vestibular dysfunction (with minocycline) All oral tetracyclines cause nausea, vomiting, and diarrhea and can cause C difficile - induced diarrhea (pseudomembranous colitis) and candidal superinfections.