Backgrounds: To evaluate the feasibility, efficacy and safety of laparoscopic cholecystectomy in acute lithiasic cholecystitis. Methods: We had 396 consecutive patients with acute cholecystitis undergoing laparoscopic cholecystectomy from Jan 01, 2004 to Dec 31, 2008 at Cho Ray Hospital, Hochiminh City. Results: Rate of success for laparoscopic cholecystectomy was 94.4% (374/396), including 335 patients (84.6%) with acute cholecystitis without necrosis and 61 patients with necrosis of the gallbladder.