High-Pressure Injection Injuries By Michael I Greenberg, MD, Drexel University College of Medicine; David Vearrier, MD, MPH, University of Mississippi Medical Center Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Key Points High-pressure injection (HPI) injuries are rare injuries that occur when substances are accidentally injected by industrial equipment under pressure high enough to breach the skin.