Treatment of Hyperkalemia Treatment of the cause For mild hyperkalemia, sodium polystyrene sulfonate, patiromer, or sodium zirconium cyclosilicate For moderate or severe hyperkalemia, IV insulin and glucose, an IV calcium solution, possibly an inhaled beta 2-agonist, and usually hemodialysis Mild hyperkalemia Patients with serum potassium < 6 mEq / L (< 6 mmol / L) and no ECG abnormalities may respond to diminished potassium intake or stopping potassium-elevating drugs.