Preseptal and Orbital Cellulitis (Periorbital Cellulitis) By Richard C Allen, MD, PhD, Baylor College of Medicine Reviewed / Revised Oct 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Preseptal and orbital cellulitis Preseptal Cellulitis Orbital Cellulitis Ethmoid Sinusitis With Subperiost... Preseptal cellulitis (periorbital cellulitis) is infection of the eyelid and surrounding skin anterior to the orbital septum.