Results: There are 7 studies, in which 5 are randomized controlled trials and 2 are prospective studies with pre and post - treatment comparisons with 448 patients in this review, of recent 10 years duration. The antibiotics used in the studies are Clarythromycin and Azithromycin, half - dose and lasting 4 to 24 weeks; There are 6 studies showed improvement in the SNOT 20/22 scale with p< 0.05; 5 studies found an improvement in the endoscopy scale of Lun - Kenedy with p < 0.05; only two studies evaluated by CT Lund - Mackay scale showed improvement with p< 0.05; four studies evaluating tissue eosinophil presence, serum IgE, and Nasal secretion found whether macrolide therapy is effective in the patients with low IgE.