The main effects of IL-17 are Proinflammatory action Stimulation of production of cytokines (eg, TNF, IL-1 beta, IL-6, IL-8, G-CSF) Clinical relevance of IL-17 includes For anti-IL-17A mAb, treatment of adults with active ankylosing spondylitis, active psoriatic arthritis, or moderate to severe plaque psoriasis IL-18 is produced by monocytes, macrophages, and dendritic cells.