It is done When the recipient is immunocompromised (eg, patients with congenital immune deficiency syndromes, hematologic cancers, or hematopoietic stem cell transplants; neonates) When donor blood is obtained from a 1st-degree relative When HLA-matched components, excluding stem cells, are transfused Treatment with corticosteroids and other immunosuppressants, including those used for solid organ transplantation, is not an indication for blood irradiation.