Necrotizing Soft-Tissue Infection (Necrotizing Cellulitis; Necrotizing Fasciitis; Necrotizing Subcutaneous Infection) By Wingfield E Rehmus, MD, MPH, University of British Columbia Reviewed / Revised Jun 2023 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Prognosis Key Points Topic Resources Group A Streptococci (Necrotizing... Fournier Gangrene (Necrotizing... Fournier Gangrene Necrotizing Fasciitis Clostridial Myonecrosis of... Necrotizing Subcutaneous... Fournier Gangrene (X-Ray) Fournier Gangrene (Abdominal... Necrotizing soft-tissue infection is typically caused by a mixture of aerobic and anaerobic organisms that cause necrosis of subcutaneous tissue, usually including the fascia.