Ventricular Septal Defect (VSD) By Lee B Beerman, MD, Children's Hospital of Pittsburgh of the University of Pittsburgh School of Medicine Reviewed / Revised Apr 2023 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points More Information Topic Resources Ventricular Septal Defect... Ventricular septal defect Ventricular Septal Defect... Overview of Ventricular Septal... A ventricular septal defect (VSD) is an opening in the interventricular septum, causing a shunt between ventricles.