Objective: To evaluate the correlation between clinical features and concentration of alpha-fetoprotein in serum of 73 hepatocellular carcinomas which were diagnosed at Cho Ray hospital from December 2009 to May 2010.Methods and materials: Seventy three consecutive hepatocellular carcinoma cases were diagnosed at the Cho Ray Hospital between 12/2009 and 5/2010 with clinical and histopathological data.