These parameters include Transpulmonary gradient (TPG, defined as the mean pulmonary artery pressure to pulmonary artery occlusion pressure gradient) > 12 mm Hg Pulmonary vascular resistance (PVR, defined as the TPG divided by the cardiac output) ≥ 3 Woods units Diastolic pulmonary gradient (DPG, defined as the pulmonary artery diastolic pressure to pulmonary artery occlusion pressure gradient) ≥ 7 mm Hg In most patients, pulmonary hypertension eventually leads to right ventricular hypertrophy followed by dilation and right ventricular failure.