Unconjugated hyperbilirubinemia is most often caused by ≥ 1 of the following: Increased production Decreased hepatic uptake Decreased conjugation Conjugated hyperbilirubinemia is most often caused by ≥ 1 of the following: Dysfunction of hepatocytes (hepatocellular dysfunction) Slowing of bile egress from the liver (intrahepatic cholestasis) Obstruction of extrahepatic bile flow (extrahepatic cholestasis) Consequences Outcome is determined primarily by the cause of jaundice and the presence and severity of hepatic dysfunction.