Skin Manifestations of Internal Disease By Julia Benedetti, MD, Harvard Medical School Reviewed / Revised Dec 2021 | Modified Sep 2022 View Patient Education Topic Resources Dermatomyositis Dermatomyositis (Resulting... Leser-Trélat Sign Erythema Gyratum Repens Necrobiosis Lipoidica Erythema Nodosum Eruptive Xanthoma (Skin) The skin frequently serves as a marker for underlying internal disease.