Immunosuppressants Immunosuppressants are used when Patients cannot tolerate prednisone Sarcoidosis is refractory to moderate to high doses of prednisone Prednisone dose cannot be tapered below 10 to 15 mg daily after 3 months Prior to adding other immunosuppressants, possible reasons for lack of clinical improvement, such as noncompliance, comorbid disease (eg, asthma, heart failure, anemia), pulmonary hypertension, and end-stage fibrosis should be considered.