After using evaporator equipment on the extracts, the residues were formed and symbolized as: exttotal EtOH, extn-Hex, extDC, extremaining EtOH The sponge extracts were investigated for cytotoxicity by the Brine-shrimp testing (Artemia salina), 3 out of 4 samples were well inhibited, which are the total EtOH extract, dichloromethane extract, and the remaining ethanol extract, with LC50less than 50μg / mL.