Medication-Related Osteonecrosis of the Jaw (MRONJ) (MRON of the Jaw) By Stuart B Goodman, MD, PhD, Stanford University Reviewed / Revised Mar 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Medication-related osteonecrosis of the jaw has no unanimously accepted definition or etiology but is generally held to be an oral lesion involving bare mandibular or maxillary bone present for ≥ 8 weeks related to medications.