90% MeOH extract of Dictyopteris polypodioides exhibited the strongest α-amylase and α-glucosidase inhibitory with IC50 (52.95±0.28 mgL-1, 88.04±0.05 mgL-1), respectively, non-different with Acarbose (60.88±0.48 mgL-1, 92.16±1.67 mgL-1).