Patients with the poorest prognosis are characterized by Age > 75 at time of diagnosis Poor performance status Lactate dehydrogenase (LDH) level > 500 U / L (> 8.4 microkat / L) Platelet count > 400, 000 / microL (> 400 × 10 9 / L) Chest pain Nonepithelial histology Prognosis reference 1.