Following multi-step bioinformatics analysis, trio-based Sanger sequencing confirmation, and variant classification according to standards of The American College of Medical Genetics and Genomics - 2015, we have identified 2 urlogenic mutations in 2 patients: OH3 (KCNQ2, c.868G>A, p G290S) and OH4 (SCN2A, c.788C>T, p A263V).