IV midazolam: Titrate to patient response (mild sedation), as follows: Initial dose: 0.02 to 0.1 mg / kg IV over ≥ 2 minutes Subsequent doses (after 3 to 5 minutes): 0.005 to 0.025 mg / kg IV over ≥ 2 minutes Maximum dose: 2.5 mg / dose and 5 mg cumulative dose (1.5 mg and 3.5 mg for patients ≥ 60 years of age).