The immunoregulatory therapies include: IFN-λ to activates epithelial cells and reduces the mononuclear macrophage-mediated proinflammatory activity of IFN-αβ; Corticosteroids to inhibit inflammatory responses; Intravenous immunoglobulin (IVIG); Antagonists of the IL-1 family and IL-6; and macrophage inhibitors.