Due to the ultrafiltration - convection mechanism and large enough rate of replacement fluid, it is also possible to remove very well substances with high molecular weight such as inflammatory mediators of TNF-α, IL-1, IL-6, IL-8, IL-10, in addition to removing solutes. - Hemoperfusion is a method of filtering the blood extracorporeally that uses devices containing adsorbents (adsorbent devices).