Treatment of Bullous Keratopathy Topical hypertonic agents, drugs to lower intraocular pressure, and corneal transplantation Treatment by an ophthalmologist is required and includes topical dehydrating agents (eg, hypertonic [5%] sodium chloride drops and ointment), intraocular pressure-lowering agents, occasional short-term use of therapeutic soft contact lenses for some mild to moderate cases, and treatment of any secondary microbial infection.