Limb Pain By Andrea D Thompson, MD, PhD, University of Michigan; Michael J Shea, MD, Michigan Medicine at the University of Michigan Reviewed / Revised Jul 2022 | Modified Sep 2022 View Patient Education Etiology Evaluation Treatment Key Points Topic Resources Streptococcal Cellulitis Cholesterol Crystal Embolization Some Causes of Nontraumatic... Limb pain may affect all or part of an extremity (for joint pain, see Pain in and Around a Single Joint and Pain in Multiple Joints).