Seizure Disorders By Bola Adamolekun, MD, University of Tennessee Health Science Center Reviewed / Revised Mar 2022 | Modified Sep 2022 View Patient Education Etiology Classification Symptoms and Signs Diagnosis Prognosis Treatment Key Points Topic Resources Glasgow Coma Scale Causes of Seizures Manifestations of Focal-Onset... Clinical Clues to the Causes... Overview of Epilepsy A seizure is an abnormal, unregulated electrical discharge that occurs within the brain's cortical gray matter and transiently interrupts normal brain function.