Bartter Syndrome and Gitelman Syndrome (Bartter's Syndrome; Gitelman's Syndrome) By Christopher J LaRosa, MD, Perelman School of Medicine at The University of Pennsylvania Reviewed / Revised Dec 2022 View Patient Education Pathophysiology Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Some Differences Between... Subtypes of Bartter Syndrome * Bartter syndrome and Gitelman syndrome are autosomal recessive renal disorders characterized by fluid, electrolyte, urinary, and hormonal abnormalities, including renal potassium, sodium, chloride, and hydrogen wasting; hypokalemia; hyperreninemia and hyperaldosteronism without hypertension; and metabolic alkalosis.