For example, Coccidioidomycosis: Confined primarily to the southwestern US, Washington, northern Mexico, and Central and South America Histoplasmosis: Occurring primarily in the eastern and Midwestern US and parts of Central and South America, Africa, Asia, and Australia Blastomycosis: Confined to North America and Africa Paracoccidioidomycosis (formerly, South American blastomycosis): Confined to that continent However, travelers can manifest disease any time after returning from endemic areas.