HSV serologic testing should be considered for the following; To evaluate patients who have no suspicious genital lesions but who require or request evaluation (eg, because of past genital lesions or high-risk behaviors) To help determine risk of developing lesions To identify pregnant women who do not have genital lesions but are at risk of transmitting herpes to the neonate during delivery To determine whether a person is susceptible to infection from a sex partner with genital herpes Treatment of Genital Herpes Acyclovir, valacyclovir, or famciclovir Genital herpes is treated with antiviral drugs.