Diabetic Nephropathy (End-Stage Renal Disease) By Frank O'Brien, MD, Washington University in St Louis Reviewed / Revised Jun 2023 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Treatment Prognosis Key Points More Information Topic Resources Urinary Protein Excretion... Diabetic Nephropathy (Mesangial... Diabetic Nephropathy (Nodules) Diabetic Nephropathy (Hyalinosis) Diabetic nephropathy is glomerular sclerosis and fibrosis caused by the metabolic and hemodynamic changes of diabetes mellitus.