Platelets Platelet concentrates are used To prevent bleeding in asymptomatic severe thrombocytopenia (platelet count < 10, 000 / mcL (<10 × 10 9 / L)) For bleeding patients with less severe thrombocytopenia (platelet count < 50, 000 / mcL (< 50 × 10 9 / L)) For bleeding patients with platelet dysfunction due to antiplatelet drugs but with normal platelet count For patients receiving massive transfusion that causes dilutional thrombocytopenia Platelet concentrates are also sometimes used before invasive surgery, particularly with extracorporeal circulation for > 2 hours (which often makes platelets dysfunctional).