Result: In this study including 54 cardiac surgerys patient undergoing general anesthesia with cardiopulmonary bypass, proportion of men was 53.7% and 46.3% women; mean aged 47.1 ± 11.6ys; mean BMI 22.16; mean anesthesia time 348.6 ± 63.8mins; mean cardiopulmonary bypass time 159.2 ± 40.3mins; mean ventilation time 573.0 ± 386.5mins, mean neuromuscular blockade dose 157.8 ± 32.5mg.