Primary Sclerosing Cholangitis (PSC) By Christina C Lindenmeyer, MD, Cleveland Clinic Reviewed / Revised Sep 2021 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Overview of Primary Sclerosing... Primary sclerosing cholangitis (PSC) is patchy inflammation, fibrosis, and strictures of the bile ducts that has no known cause.