Treatment of Retinoblastoma For advanced unilateral cancer, enucleation For less advanced unilateral cancer, sometimes chemotherapy and / or local-control treatments For bilateral cancer, photocoagulation, intra-arterial chemotherapy, or unilateral enucleation with photocoagulation, cryotherapy and irradiation of the other eye Systemic chemotherapy The goal of retinoblastoma treatment should be cure, but attempts to preserve as much vision as possible are appropriate.