The patients showed increase of IL-2 concentrations, decrease of IL-4, IL-6, TNF-α and IFN - concentrations (p < 0, 05 - 0, 001); T-CD3, T-CD4 and NK CD56 lympho count increased significantly (p < 0, 01 - 0, 001), There is strict linear correlation between SLEDAI and changes in lymphocytic subsets post-treatment (r=0, 45, p<0, 001).