There were significantly differences about anti-HBs titer at protection level between children with full-dose hepatitis B vaccine and whom without full-dose hepatitis B or between correctly national schedule group and incorrectly national schedule group (p <0.001). Conclusions: newborns should receive the first dose of hepatitis B vaccine as soon as possible after birth, preferably within 24 hours and with three doses of hepatitis B vaccine the rate of infection with hepatitis B will probably reduce significantly in the future.