The most common cause of acute urate nephropathy is Tumor lysis syndrome after treatment of lymphoma, leukemia, or other myeloproliferative disorders Other causes of acute urate nephropathy include seizures, treatment of solid tumors, rare primary disorders of urate overproduction (hypoxanthine-guanine phosphoribosyltransferase deficiency), and disorders of urate overexcretion due to decreased proximal tubule reabsorption (Fanconi-like syndromes).