Skin examination Chronic kidney disease can cause any of the following: Xerosis due to sebaceous and eccrine sweat gland atrophy Pallor due to anemia Hyperpigmentation due to melanin deposition Sallow or yellow-brown skin due to urochrome deposition Petechiae or ecchymoses due to platelet dysfunction Excoriation due to itching caused by hyperphosphatemia or uremia Uremic frost, the deposition of white-to-tan urea crystals on the skin after sweat evaporation, is rare.