Symptoms and Signs of Granuloma Inguinale Sites of infection are Penis, scrotum, groin, and thighs in men Vulva, vagina, and perineum in women Anus and buttocks in patients who engage in anal-receptive intercourse Face in both sexes After an incubation period of about 1 to 12 weeks, a painless, red skin nodule slowly enlarges, becoming a raised, beefy red, moist, smooth, foul-smelling lesion.