Appropriate antibiotics with bactericidal activity include A fluoroquinolone (eg, ciprofloxacin 400 mg [10 to 15 mg / kg for children] IV every 12 hours, levofloxacin 750 mg IV every 24 hours, or moxifloxacin 400 mg IV every 24 hours) A carbapenem (meropenem 2 g IV every 8 hours or imipenem 1 g IV every 6 hours) Vancomycin IV dosing to maintain serum trough concentration of 15 to 20 mcg / mL (10.4 to 13.8 micromol / L) For penicillin-susceptible strains, penicillin G 4 million units IV every 4 hours or ampicillin 3 g IV every 4 hours Appropriate antibiotics that inhibit protein synthesis include Linezolid 600 mg IV every 12 hours Clindamycin 900 mg IV every 8 hours Rifampin 600 mg every 12 hours Chloramphenicol 1 g IV every 6 to 8 hours Linezolid should be used with caution in patients with myelosuppression; it cannot be used for long periods because of its neurologic side effects.