Staging of neuroblastoma The following should be done to evaluate for metastases: Bone marrow aspirates and marrow core biopsies from multiple sites (typically, both posterior iliac crests) Bone scan or iodine-131 metaiodobenzylguanidine (MIBG) scan (MIBG uptake occurs in > 90% of neuroblastomas) Abdominal, pelvic, and chest CT or MRI Cranial imaging with CT or MRI is indicated if symptoms or signs suggest brain metastases.