The primary indication for kidney transplantation is End-stage renal failure Absolute contraindications include Comorbidities that could compromise graft survival (eg, severe heart disorders, cancer), which can be detected via thorough screening Relative contraindications include Poorly controlled diabetes, which can lead to rapid failure of the allograft Patients in their 70s and sometimes 80s may be candidates for transplants if they are otherwise healthy and functionally independent with good social support, if they have a reasonably long life expectancy, and if transplantation is likely to substantially improve function and quality of life beyond simply freeing them from dialysis.