Absolute contraindications to liver transplantation are Elevated intracranial pressure (> 40 mm Hg) or low cerebral perfusion pressure (< 60 mm Hg) in patients with fulminant hepatic necrosis Severe pulmonary hypertension (mean pulmonary arterial pressure > 50 mm Hg) Sepsis Advanced or metastatic hepatocellular carcinoma All of these conditions lead to poor outcomes during or after transplantation.