In hot plate model: After treatments 30 and 90 minutes, DHLD at the dose of 450 mg / kg increased reaction times with heat 4.07% and 1.6% compared to before treatment, not significantly different; DHLD at the dose of 560 mg / kg increased reaction times 32.76% (p <0.001) and 3.47% compared to before treatment; DHLD at the dose of 750 mg / kg increased reaction times 51.91% (p <0.001) and 15.57% (p <0.05) compared to before treatment.