Maternal infection should be suspected if women have one or more of the following: A mononucleosis-like syndrome and negative tests for Epstein-Barr virus, HIV, and cytomegalovirus (antibody or PCR) Isolated regional adenopathy not due to another cause (eg, HIV) Chorioretinitis Acute maternal infection is suggested by seroconversion or a ≥ 4-fold rise between acute and convalescent IgG titers.