Sinusoidal Obstruction Syndrome (Veno-Occlusive Disease) By Whitney Jackson, MD, University of Colorado School of Medicine Reviewed / Revised Jan 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Hepatic sinusoidal obstruction syndrome is caused by endothelial injury, leading to nonthrombotic occlusion of the terminal hepatic venules and hepatic sinusoids, rather than of the hepatic veins or inferior vena cava (as in Budd-Chiari syndrome).