Restrictive Cardiomyopathy By Tisha Suboc, MD, Rush University Reviewed / Revised Nov 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points Topic Resources Causes of Restrictive Cardiomyopa... Restrictive cardiomyopathy is characterized by noncompliant ventricular walls that resist diastolic filling; one (most commonly the left) or both ventricles may be affected.