The Curaçao criteria include the following: Spontaneous recurrent epistaxis Multiple telangiectasias in typical locations Documented visceral arteriovenous malformations (eg, in the lung, liver, brain, and spine) First-degree family member with hereditary hemorrhagic telangiectasia Hereditary hemorrhagic telangiectasia is definite if 3 of these criteria are met and possible if 2 are met (1, 2).