On the model of endogenous dyslipidemia, Folium Nelumbinis and Radix Polygoni multiflori combination (2 - 1 ratio) with dose 0.8 g Folium nelumbinis - 0.4 g Polygonum multiflorum decreased 23.21% total cholesterol, 25.49% triglyceride and 43.43% LDL-C On the model of exogenous dyslipidemia, Folium Nelumbinis and Radix Polygoni multiflori combination (2 - 1 ratio) with dose 0.8 g Folium nelumbinis - 0.4 g Radix Polygoni multiflori reduced 49.20% total cholesterol and 46.67% LDL-C. Conclusion: Combining Folium Nelumbinis and Radix Polygoni multiflori with 2 - 1 ratio is optimal for the prevention of dyslipidemia.