Drugs used depend on the type of ACS and include Aspirin, clopidogrel, or both (prasugrel or ticagrelor are alternatives to clopidogrel if fibrinolytic therapy has not been given) Beta-blocker Glycoprotein IIb / IIIa inhibitor considered for certain patients undergoing percutaneous coronary intervention (PCI) and high risk lesions (eg, high thrombus burden, no reflow) A heparin (unfractionated or low molecular weight heparin) or bivalirudin (particularly in ST-segment elevation myocardial infarction [STEMI] patients at high risk of bleeding) IV nitroglycerin (unless low-risk, uncomplicated myocardial infarction) Fibrinolytics for select patients with STEMI when timely PCI unavailable Angiotensin-converting enzyme (ACE) inhibitor (as early as possible) Statins Antiplatelet and antithrombotic drugs, which stop clots from forming, are used routinely.