Hepatocytes also make proteins that aid in the diagnosis of specific disorders: Alpha-1 antitrypsin (absent or decreased in alpha-1 antitrypsin deficiency) Ceruloplasmin (reduced in Wilson disease) Transferrin (saturated with iron in hemochromatosis) Ferritin (greatly increased in hemochromatosis) These proteins usually increase in response to damage (eg, inflammation) to various tissues, so that elevations may not specifically reflect liver disorders.