Status and aim of study: Studies proving roles of Cytokines, lympho T, intrinsic growth factor... in pathology mechanism of Rheumatoid-arthritis has turned upside down classic treatment measures that have existed for more than 30 years; painkillers and anti-inflammatories became less important; and more studies are being conducted to find a new anti-Rheumatoid-arthritis medicine that has the effect of modifying lifestyle so as to take the place of Methotrexate, which is one of the most effective medicine nowadays but also has many side effects.