Linezolid Linezolid is an oxazolidinone antibiotic that has activity against the following: Streptococci Enterococci, including vancomycin - resistant enterococci (VRE) Staphylococci, including methicillin-resistant S aureus (MRSA) and other strains resistant to other classes of antibiotics Mycobacteria, including Mycobacterium tuberculosis Anaerobes, such as Fusobacterium, Prevotella, Porphyromonas, and Bacteroides species and peptostreptococci Contraindications to Linezolid Linezolid is contraindicated in patients with a prior allergic reaction to it.