Vaccination with ACAM2000 is dangerous and not recommended for some people, especially those with the following risk factors: Weakened immune system (such as those who have AIDS or who take medications that suppress the immune system) Skin disorders (particularly atopic dermatitis [eczema]) Eye inflammation Heart condition Age under 1 year Pregnancy Infection control Non-hospitalized patients with mpox should Isolate at home until the lesions have resolved and scabs have fallen off and a fresh layer of intact skin has formed Avoid direct physical contact with other people and animals Not share potentially contaminated items, such as bed linens, towels, clothing, drinking glasses, or eating utensils, and should clean and disinfect commonly touched surfaces and items Wear a mask if close contact with others in the home is necessary Infection control measures in the hospital include having patients in a private room with the door closed.