15-Methyl prostaglandin F2-alpha 250 mcg IM every 15 to 90 minutes up to 8 doses or methylergonovine 0.2 mg IM every 2 to 4 hours (which may be followed by 0.2 mg orally 3 to 4 times a day for 1 week) should be tried if excessive bleeding continues during oxytocin infusion; during cesarean delivery, these drugs may be injected directly into the myometrium.