Our study was designed to evaluate anti-inflamatory effect of Blumea balsamifera on mice. Study design and Setting: An experimental study was carried out on swiss albino mice were given Blumea balsamifera extract (2: 1) / ethanol 90% và ethanol 70%. Outcome measures: The percentage of granuloma inhibition, infection levels of S pneumoniae, the level of inflammatory sinus nasal mucosa of mice caused by S pneumonia are outcome measurements. Results: Inhibitory effect of Blumea balsamifera extract (40g / kg, per oral) on fresh granulomas is 20.87% (p <0.05) and on dry granulomas is 28.93% (p <0.05).