Patients and Method: From 07/2012 to 01/2013, a prospective, case-control analysis study, choosing 60 patients ≥ 16 years old, no diabetes, 15 ml / min/1.73 m2 ≤ eGFR ≤ 15 ml / min / 1.73 m2, good nutritious status, divided into 2 groups, each group 30 patients. Rather than the common treatment, group A is consulted to eat 0.3g protein / kg / day plus keto acid 1 tablet/5 kg body weight / day, group B eated 0.6g protein/kg/day.