The main effects of IFN-gamma are Inhibition of viral replication Augmentation of classes I and II MHC expression Activation of macrophages Antagonism of several actions of IL-4 Inhibition of Th2 cell proliferation Clinical uses of IFN-gamma include Control of infection in chronic granulomatous disease Delay of progression in severe malignant osteopetrosis Interleukins (ILs) Interleukins (IL-1 to IL-38) are collectively produced by a wide variety of cells and have multiple effects on cell development and the regulation of immune responses.