In RENAAL, 1513 adults with type 2 diabetes, albuminuria >300 mg / day (median urinary ACR of approximately 1250 mg / g), and mean serum creatinine 1.9 mg / dL (168 micromol / L) were randomly assigned to losartan (50 titrating up to 100 mg once daily) or placebo; additional drugs were added as need to attain goal blood pressure [48].