Systemic diseases associated with hematologic disease that can manifest as periodontitis include Acquired neutropenia Agranulocytosis Leukemias Lazy leukocyte syndrome Hypogammaglobulinemia Systemic diseases associated with genetic disorders that can manifest as periodontitis include Familial and cyclic neutropenia Down syndrome Leukocyte adhesion deficiency syndromes Papillon-Lefèvre syndrome Chédiak-Higashi syndrome Histiocytosis syndromes Glycogen storage disease Infantile genetic agranulocytosis Ehlers-Danlos syndrome (types IV and VIII) Hypophosphatasia Cohen syndrome Crohn disease Periodontitis The previous (AAP, 1999) classification distinguished between chronic and aggressive periodontitis.