Even with treatment, death is more likely and the prognosis is generally poorer for older people and people who have Infection with resistant organisms An underlying disorder A long delay in treatment Aortic valve or multiple valve involvement Large vegetations Polymicrobial bacteremia Prosthetic valve infections Mycotic aneurysms Valve ring abscess Major embolic events Septic shock is more likely in patients with diabetes, acute kidney injury, S aureus infection, vegetation size > 15 mm, and signs of persistent infection.