Lefamulin By Brian J Werth, PharmD, University of Washington School of Pharmacy Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Pharmacokinetics Indications Contraindications Use in Pregnancy and Breastfeeding Adverse Effects Lefamulin is a pleuromutilin antibiotic that inhibits bacterial protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA.