Disseminated Intravascular Coagulation (DIC) (Consumption Coagulopathy; Defibrination Syndrome) By Joel L Moake, MD, Baylor College of Medicine Reviewed / Revised Sep 2021 | Modified Sep 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Fibrinolytic pathway Overview of Disseminated.. Disseminated intravascular coagulation (DIC) involves abnormal, excessive generation of thrombin and fibrin in the circulating blood.