Accordingly, metabolic risks across tertile of HMW adiponectin showed that the lowest tertile associated with a higher risk for insulin resistance (OR 1.73, [95% CI, 1.36 to 2.20]), glucose intolerance (OR 1.45 [95% CI, 1.14 to 1.84]), metabolic syndrome (OR 1.33 [95% CI, 1.01 to 1.75]) and type 2 diabetes (OR 1.38 [95% CI, 1.03 to 1.85]) compared with the highest tertile of HMW adiponectin.