Change in PASI before and after treatment (n=35) n PASI (X±SD) PASI down p Before 35 25, 38 ± 4, 20 Cytokine (pg / ml) Before treatment After treatment p (sign test) IL-2 (X±SD) 2, 00 ± 0, 00 2, 00 ± 0, 00 >0, 05 IL-6 (X±SD) 42, 27 ± 98, 35 16, 22 ± 40, 01 >0, 05 IL-8 (X±SD) 495, 15 ± 783, 80 609, 80 ± 902, 12 >0, 05 IL-10 (X±SD) 3, 92 ± 3, 84 3, 40 ± 2, 99 >0, 05 IL-12 (X±SD) 1, 47 ± 0, 60 1, 46 ± 0, 60 >0, 05 IL-17 (X±SD) 1, 04 ± 2, 11 0, 65 ± 0, 84 >0, 05 TNF-α (X±SD) 4, 88 ± 7, 78 3, 55 ± 1, 39 >0, 05 INF - (X±SD) 2, 37 ± 3, 24 1, 43 ± 0, 53 <0, 05 15 treatment (1) 16, 09 (63, 39%) p12, p13, p23 < 0, 001 After 5 weeks of treatment (2) 35 9.29 ± 3.20 After 10 weeks of treatment (3) 35 5, 50 ± 3, 74 19, 88 (78, 33%) Conclusion: After treatment of psoriasis with cyclosporin A, PASI decreased 5 weeks (63, 39%), 10 weeks (78.33%), significantly (p<0.001).