Elastic tissues become calcified and fragmented, leading to disruption of the involved organ systems: Ocular system: Angioid streaks of the retina, retinal hemorrhages, and gradual vision loss Cardiovascular system: Premature atherosclerosis with subsequent intermittent claudication, hypertension, angina, and myocardial infarction Vascular fragility: Gastrointestinal hemorrhage and small-vessel bleeding with subsequent anemia Diagnosis of Pseudoxanthoma Elasticum Clinical evaluation Diagnosis of pseudoxanthoma elasticum is based on clinical and histologic findings.