Treatment of Microsporidiosis For patients with AIDS, initiation or optimization of antiretroviral therapy (ART) For gastrointestinal, skin, muscle, or disseminated microsporidiosis, oral albendazole or fumagillin (where available), depending on the infecting species For keratoconjunctivitis, oral albendazole and topical fumagillin In patients with AIDS, initiation or optimization of ART is important.