Neubauer cell counter and white blood cell count were applied to determine grade of neutropenia. Results: Interferon alfa-2b at a dose of 200.000 UI / kg, ip, 3 times / week combined with oral Ribavirin at a dose of 300 mg / kg / day x 14 days induced pathologically neutropenia. Conclusion: This mouse model can be applied for screening agents that exert protective effect on Carboplatin-induced neutropenia.