Objective: The aim of this study was to evaluate the efficiency of 5% potassium nitrate and 0.221% sodium fluoride containing toothpaste in reducing dentin hypersensitivity (DH) during home whitening. Materials and method: The trial was conducted on 70 subjects (19 - 28 years-old) wearing individual tray containing 20% carbamide peroxide in 2 hours every day for 14 days.