+ In clinical trial: the study results shows the evidences that Hoang Kinh capsules in combination with Methotrexat during 30 days could improved significantly the symptoms of rheumatoid arthritis disease but has no side effects: The degree of pain on scale of VAS1, VAS2, the average number of swollen joints, erythrocyte sedimentation rate, C - reaction protein and ACR 20, which have significantly reduced after treatment in comparing with before treatment and with the control group (p<0.05).