Optimum extraction of breadfruit leaves has good ability to neutralize free radicals 2, 2'-azino-bis (3 - ethylbenzothiazoline-6-sulfonic acid) (EC50=56.57±0.10 µg / mL) and 2, 2 - diphenyl-1-picrylrylhydrazyl (EC50=68.85±0.53 µg / mL) and nitric oxide (EC50=77.21±0.84 µg / mL).