To evaluate the impact of compliance on mortality, and the organisational charateristics of Asian hospitals which are associated with high compliance. Objects: 16 countries, 150 ICUs with 1825 severe sepsis patients in Asia for 1 month. Method: the prospective observational study. Results: mortality rate is 44.9%, achievement rates for the bundle targets were: lactate measurement, 39.8%; blood cultures, 62.5%; broad-spectrum antibiotics, 64.0%; fluids ±vasopressors, 81.4%; central venous pressure, 39.7%; central or mixed venous oxygen saturation, 10.8%; low-dose steroids, 55.8%; drotrecogin alfa, 3.2%; glucose control, 27.1%; lung-protective ventilation, 11.7%.