The average amounts of HBV DNA decrease in patients using antiviral drugs were 2, 3 x 108 copies / ml with adefovir and 4, 2 x108 copies / ml with lamivudine, and the average numbers of HBV DNA increase were 1, 4 x 108 copies / ml with lamivudine and 7, 5 x 107 copies / ml with entecavir.