From March 01, 2010 to July 31, 2011, we analysed Acute Myeloid Leukemia patients at Blood Transfusion Hematology Hospital. Results: 19 patients expressing AML1/ETO (11.7%), 11 patients expressing PML / RARA (6.8%), 7 patients expressing CBFB / MYH11 4.3%), and 8 patients expressing MLL / AF9 (2.5%), among 162 newly diagnosed patients with AML Conclusion: RT-PCR is simple and highly sensitive technique that should apply to detect the frequent chromosome translocations not only in AML but also in other hematologic malignancies in hematology centers in Vietnam.