Patients with chronic hepatitis C with genotypes 1, 4, 5 or 6 treated Ledipasvir + Sofosbuvir (Ledvir) on tablet per day and lasts 12 weeks, genotypes 1.2.3.4.5 and 6 treatment of Velpatasvir + Sofosbuvir (Velsof) one tablet per day and lasts 12 weeks.