Contraindications and Precautions of Influenza Vaccine The main contraindication for IIV is A severe allergic reaction (eg, anaphylaxis) after previous dose of IIV Precautions with IIV include Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves) Guillain-Barré syndrome (GBS) within 6 weeks after a previous dose of an influenza vaccine Contraindications for LAIV include A severe allergic reaction (eg, anaphylaxis) to any vaccine component (excluding egg) or to a previous dose of any influenza vaccine Immunocompromise (eg, due to disorders, including HIV infection, or use of immunosuppressants) For children and adolescents, concomitant use of aspirin or other salicylates Close contact with and / or caring for severely immunocompromised patients who require a protected environment (unless contact is avoided for 7 days after receiving LAIV) Pregnancy Anatomical or functional asplenia Receipt of influenza antiviral drugs in the past 48 hours Cerebrospinal fluid leak or a cochlear implant Age < 2 years or ≥ 50 years Age 2 to 4 years if children have asthma or have had wheezing or asthma episodes in the past 12 months Precautions for LAIV include Certain chronic disorders such as chronic lung, heart, kidney, liver, hematologic (eg, hemoglobinopathies), or metabolic (eg, diabetes mellitus) disorders Asthma in people aged ≥ 5 years Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves) Guillain-Barré syndrome within 6 weeks after a previous dose of an influenza vaccine Use of specific antiviral drugs: ie, amantadine, rimantadine, zanamivir, oseltamivir (these drugs are stopped 48 hours before vaccination and are not resumed for 14 days after vaccination) The main contraindication for RIV4 is A severe allergic reaction (eg, anaphylaxis) after a previous dose of RIV4 Precautions with RIV4 include Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves) Guillain-Barré syndrome within 6 weeks after a previous dose of an influenza vaccine Precautions for patients with suspected egg allergy: Patients with a history of egg allergy who have had only hives after exposure to egg should be given the influenza vaccine.