Results: Serum HBcrAg concentration gradually decreased over time of treatment, from 5.94±1.36 initially to 5.50±1.47 after 3 months, 5.04±1.40 after 6 months and 4.92±1.34 after 12 months, the difference was statistically significant in serum HBcrAg levels at 3, 6 and 12 months compared with baseline (p<0.0001).