Limited data are available in clinical and cerebrospinal fluid significances of Cryptococcal neoformans meningitis in Vietnamese HIV-infected patients. Objective: Review 62 cases of Cryptococcal meningitis associated with Acquired Immuno Deficiency Syndrome (AIDS) diagnosed at Pham Ngoc Thach hospital in the last three years (from 2007 to 2009). Material and methods: Retrospective study of 62 cases of Cryptococcal neoformans meningitis in Vietnamese patients infected by human immunodeficiency virus (HIV).