The clinical and para-clinical factors relating to major bleeding were mental disorder (OR=75.9), tachycardia ³ 120 times / min (OR=6.2), tachypnea ³ 28 times / min (OR=14), recurrent shock (OR=4.7), digestive hemorrhage (OR=191.2), vaginal bleeding (OR=12.3), epistaxis (OR=44.8), decrease in hematocrit £40% (OR=13.3), prolonged Prothrombin time ³ 20 sec (OR=7.2), prolonged APTT ³ 60 sec (OR=6.1) and lactatemia ³ 5 mEq / L (OR=29.1).