Objectives: The aims of our study are to describe the epidemiologic, clinical and paraclinical signs of hepatocellular carcinoma patients. Methods: A 107 - case series was conducted in our research. These patients were diagnosed and treated as HCC at Medical ward 4 and Surgical ward 2 from 09/2009 to 06/2010 at Oncology Hospital in Ho Chi Minh City. Results: Our study results from 107 HCC cases in which male is the preponderant gender, which makes up 79%.