Factors associated with a good prognosis include Good premorbid functioning (eg, good student, strong work history) Late and / or sudden onset of illness Family history of mood disorders other than schizophrenia Minimal cognitive impairment Few negative symptoms Shorter duration of untreated psychosis Factors associated with a poor prognosis include Young age at onset Poor premorbid functioning Family history of schizophrenia Many negative symptoms Longer duration of untreated psychosis Men have poorer outcomes than women; women respond better to treatment with antipsychotic drugs.