Indications for Herpes Zoster Vaccine Indications for the zoster vaccine include Recombinant vaccine: Adults ≥ 50 years whether they have had episodes of herpes zoster or been given the live-attenuated zoster vaccine or not Recombinant vaccine: Adults ≥ 19 years who are or will be immunodeficient or immunosuppressed because of disease or therapy Recombinant vaccine or live-attenuated vaccine: Adults ≥ 60 years (the recombinant vaccine is preferred) Contraindications and Precautions of Herpes Zoster Vaccine Contraindications for the recombinant zoster vaccine include A severe allergic reaction (eg, anaphylaxis) to a vaccine component or after a previous dose of the vaccine Contraindications for the live-attenuated zoster vaccine include A severe allergic reaction (eg, anaphylaxis) to a vaccine component Known severe primary or acquired immunodeficiency (eg, due to leukemia, lymphomas, solid tumors, tumors that affect bone marrow or the lymphatic system, AIDS, severe HIV infection, treatment with chemotherapy, or long-term use of immunosuppressants) Pregnancy Precautions include Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves) For the live-attenuated zoster vaccine, use of specific antiviral drugs: acyclovir, famciclovir, or valacyclovir (if possible, vaccination is postponed until 24 hours after use of these drugs, and the drugs are not resumed for 14 days after vaccination) Clinical trials for the recombinant vaccine excluded pregnant women and women who are breastfeeding.