Antibiotics Prescribe empiric antibiotic therapy after drainage with a drug active against methicillin-resistant Staphyloccocal aureus (MRSA) and beta-hemolytic streptococci in patients who have the following: Significant associated cellulitis or septic thrombophlebitis A deep abscess Multiple or recurrent abscesses Systemic symptoms and signs Immunocompromise A facial abscess above the upper lip and below the brow High-risk heart disease, particularly with severe or extensive disease, comorbid conditions, extremes of age, or an abscess on the face, a hand, or the genitals Patients should receive antibiotics for at least 5 to 7 days after the procedure.