Treatment of Essential Thrombocythemia Sometimes aspirin Platelet-lowering drugs (eg, hydroxyurea, interferon, anagrelide) Rarely plateletpheresis Rarely cytotoxic agents Rarely stem cell transplantation For mild vasomotor symptoms (eg, headache, mild digital ischemia, erythromelalgia) in low-risk patients who are > 60 years old and do not have the Jak2 mutation, aspirin 81 mg orally once a day is usually sufficient, but a higher dose may be used if necessary.