Overview of Gastrointestinal Disorders in Neonates and Infants By William J Cochran, MD, Geisinger Clinic Reviewed / Revised Aug 2021 | Modified Sep 2022 View Patient Education Gastrointestinal disorders can affect neonates and infants: Gastroesophageal reflux Hypertrophic pyloric stenosis Intussusception Meconium ileus Meconium plug syndrome Necrotizing enterocolitis Neonatal cholestasis Neonates are also susceptible to miscellaneous surgical emergencies (inguinal hernia, gastric perforation, ileal perforation, and mesenteric arterial occlusion).