Contraindications and Precautions of Rotavirus Vaccine Contraindications for rotavirus vaccines are A severe allergic reaction (eg, anaphylaxis) after a previous dose of the vaccine or to a vaccine component (including latex, which is in the RV1 applicator) Infants with severe combined immunodeficiency Infants who have had intussusception The main precautions with rotavirus vaccines are Moderate or severe illness, including moderate or severe diarrhea or vomiting (vaccination is postponed until the illness resolves; infants with mild illness can be given the vaccine) The safety and efficacy of rotavirus vaccines have not be established in infants with the following: HIV / AIDS or any other disease that affects the immune system Treatment with corticosteroids or other immunosuppressants Cancer or cancer treatment with radiation or drugs Dose and Administration of Rotavirus Vaccine Rotavirus vaccines are given orally by putting drops in the infant's mouth.