Hand-Foot-and-Mouth Disease (HFMD) By Brenda L Tesini, MD, University of Rochester School of Medicine and Dentistry Reviewed / Revised Jun 2023 View Patient Education Topic Resources Hand-Foot-and-Mouth Disease... Hand-Foot-and-Mouth Disease... Hand-Foot-and-Mouth Disease... Hand-Foot-and-Mouth Disease... Coxsackie Virus A Exanthem... Hand-foot-and-mouth disease (HFMD) is a febrile disorder usually caused by coxsackievirus A16, enterovirus 71, or other enteroviruses.