Three dopamine agonists, pramipexole, ropinirole, and rotigotine (used as a patch), are effective and have few serious adverse effects other than augmentation: Pramipexole 0.125 mg is given orally 2 hours before onset of moderate to severe symptoms and is increased, as needed, by 0.125 mg orally every 2 nights until symptoms are relieved (maximum dose 0.5 mg).