Antipsychotics Acute manic psychosis is being increasingly managed with 2nd-generation antipsychotics, such as Aripiprazole (10 to 30 mg orally once / day) Cariprazine (1.5 to 3.0 mg once / day) Lurasidone (20 to 120 mg once / day) Olanzapine (usually 5 to 10 mg orally twice a day) Quetiapine (200 to 400 mg orally twice a day) Risperidone (usually 2 to 3 mg orally twice a day) Ziprasidone (40 to 80 mg orally twice a day) In addition, evidence suggests that these drugs may enhance the effects of mood stabilizers after the acute phase.