How To Do Procedural Sedation and Analgesia By Richard Pescatore, DO, Delaware Division of Public Health Reviewed / Revised Oct 2021 | Modified Sep 2022 View Patient Education Indications Contraindications Complications Equipment Additional Considerations Positioning Step-by-Step Description of Procedure Aftercare Warnings and Common Errors Tricks and Tips References More Information Procedural sedation and analgesia (PSA) is the administration of a short-acting sedative-hypnotic or dissociative agent, with or without an analgesic, for patients undergoing anxiety-provoking and / or painful procedures.