Despite dramatic improvements in survival and quality of life for patients with severe congenital heart defects and other heart disorders, pregnancy remains inadvisable for women with certain high-risk disorders such as the following (1): Pulmonary hypertension (pulmonary artery systolic pressure > 25 mm Hg) caused by any condition, including Eisenmenger syndrome Coarctation of the aorta if uncorrected or if accompanied by an aneurysm Marfan syndrome with aortic root diameter of > 4.5 cm Severe symptomatic aortic stenosis or severe mitral stenosis Bicuspid aortic valve with ascending aorta diameter > 50 mm A single ventricle and impaired systolic function (whether treated with the Fontan procedure or not) Cardiomyopathy with ejection fraction < 30% or New York Heart Association (NYHA) class III or IV heart failure (see table New York Heart Association (NYHA) Classification of Heart Failure) General reference 1.