Drug choices for maintenance anticoagulation include Oral vitamin K antagonist (warfarin in the US) Oral factor Xa inhibitors (apixaban, rivaroxaban, edoxaban) Oral direct thrombin inhibitor (dabigatran) Rarely subcutaneous low molecular weight heparin Warfarin is an effective long-term oral anticoagulant option that has been used for decades, but it is very inconvenient for a number of reasons.