Treatment of TGA Prostaglandin E1 (PGE1) infusion Sometimes balloon atrial septostomy Surgical repair Unless arterial oxygen saturation is only mildly decreased and the atrial communication is adequate, a PGE1 infusion may help by opening and maintaining patency of the ductus arteriosus; this infusion increases pulmonary blood flow, which may promote left-to-right atrial shunting, leading to improved systemic oxygenation.