These three anabolic agents (teriparatide, abaloparatide, and romosozumab) are generally indicated for patients who have the following characteristics: Cannot tolerate antiresorptive drugs or have contraindications to their use Fail to respond (ie, develop new fractures or lose bone mineral density) to antiresorptive drugs, as well as calcium, vitamin D, and exercise Possibly have severe osteoporosis (eg, T-score < - 3.5) or multiple vertebral fragility fractures Have corticosteroid-induced osteoporosis (teriparatide only) Any of these three anabolic agents can be considered for use during a bisphosphonate holiday.