Principles of Topical Dermatologic Therapy By Jonette E Keri, MD, PhD, University of Miami, Miller School of Medicine Reviewed / Revised May 2021 | Modified Sep 2022 View Patient Education Vehicles Dressings Topical Agents Topic Resources Relative Potency of Selected.. Topical dermatologic treatments are grouped according to their therapeutic functions and include Cleansing agents Moisturizing agents (emollients, skin hydrators, and softeners) Drying agents and super-absorbent powders Anti-inflammatory agents Antimicrobial agents Keratolytics (agents that soften, loosen, and facilitate exfoliation of the squamous cells of the epidermis) Astringents (drying agents that precipitate protein and shrink and contract the skin) Antipruritics For certain topical treatments, successful therapy may also depend on The vehicle with which an agent is formulated The type of dressing used Vehicles Topical therapies can be delivered in various vehicles, which include Powders Liquids Combinations of liquid and oil The vehicle influences a therapy's effectiveness and may itself cause adverse effects (eg, allergic contact dermatitis or irritant contact dermatitis).