Evaluation is focused at identifying causes, such as new drugs or infections, and excluding manifestations of inflammation or vasculitis in other organs, such as Lungs: Shortness of breath, cough, hemoptysis, and signs of consolidation Kidneys: New-onset hypertension or edema Nerves: New-onset asymmetric weakness or paresthesias Intestine: New-onset abdominal pain, diarrhea, and bloody stools Urinalysis should exclude blood, protein, and red blood cell casts.