Methods: Retrospective descriptive study of cases series. Results: 48 cases of MODS due to septic shock diagnosed by clinical findings and paraclinical tests, who were included, with age median of 14.5 month old, youngest of 3 month old, male accounting for 58.3%, female 41.7%, have been given CVVH or CVVHDF, showing improvement on clinical findings such as level of consciousness, cardiac rate, temperature, pallor, mottled skin as well as betterment on metabolic acidosis, level of lactate.