How To Do Local Wound Infiltration By Richard Pescatore, DO, Delaware Division of Public Health Reviewed / Revised Oct 2021 | Modified Sep 2022 View Patient Education Indications Contraindications Complications Equipment Additional Considerations Relevant Anatomy Positioning Step-by-Step Description of Procedure Tips and Tricks Topic Resources How To Anesthetize Wounds... Local anesthetic can be injected directly into the exposed subcutaneous tissue of an open skin wound before cleansing, repair, and closure.