Simple Nontoxic Goiter (Euthyroid Goiter) By Glenn D Braunstein, MD, Cedars-Sinai Medical Center Reviewed / Revised Aug 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Simple nontoxic goiter, which may be diffuse or nodular, is noncancerous hypertrophy of the thyroid without hyperthyroidism, hypothyroidism, or inflammation.