Because of antimicrobial resistance and because chlamydial genital infection is often present in patients with gonorrhea, adult gonococcal conjunctivitis requires dual therapy with a single dose of ceftriaxone 1 g IM plus azithromycin 1 g orally once (to treat possible chlamydial co-infection [trachoma]) or with doxycycline 100 mg orally twice a day for 7 days if azithromycin allergy.