Anaesthesia 76: 655 - 664, 2021. doi: 10.1111 / anae.15317 Treatment of Malignant Hyperthermia Rapid cooling and supportive measures Dantrolene It is critical to cool patients with malignant hyperthermia as quickly and effectively as possible (see Heatstroke: Treatment) to prevent damage to the central nervous system and also to give patients supportive treatment to correct metabolic abnormalities.