Treatment of SBP Cefotaxime or another antibiotic Albumin for prevention of hepatorenal syndrome If SBP is diagnosed, an antibiotic such as ceftriaxone or cefotaxime 2 g IV every 4 to 8 hours (pending Gram stain and culture results) is given for at least 5 days and until ascitic fluid shows < 250 PMNs / mcL.