Diagnostic criteria for tumor lysis syndrome include Acute kidney injury Hypocalcemia (calcium < 7 mg / dL [< 1.75 mmol / L]) Hyperuricemia (uric acid > 8 mg / dL [> 0.48 mmol / L]) Hyperphosphatemia (phosphorus > 6.5 mg / dL [> 2 mmol / L]) Hyperkalemia (potassium > 6 mEq / L [> 6 mmol / L]) Treatment of tumor lysis syndrome is with allopurinol 200 to 400 mg / m 2 once a day, maximum 600 mg / day, and normal saline IV to achieve urine output > 2 L / day should be initiated with close laboratory and cardiac monitoring.