Objective: To identify the clinical features, and factors related to the quality of life in patients with eczema on hand and foot, who admitted to the Hospital of Dermato Venereology in Ho Chi Minh City Subjects and Methods: 200 patients with eczema on hand and foot admitted to the Ho Chi Minh City Hospital of Dermatology were enrolled in a series case descriptive study where they would be interviewed (by a set of questionnaires) and medically examined.