For drug-induced warm antibody hemolytic anemia, drug withdrawal and sometimes IV immune globulin For idiopathic warm antibody hemolytic anemia, corticosteroids and, in refractory cases, rituximab, IV immune globulin, or splenectomy For cold agglutinin disease, avoidance of cold and treatment of underlying disorder For PCH, avoidance of cold, immunosuppressants, and treatment of syphilis if present.