Goodpasture syndrome is the prototype cause, but pulmonary-renal syndrome can also be caused by systemic lupus erythematosus, granulomatosis with polyangiitis, microscopic polyangiitis, and, less commonly, by other vasculitides, connective tissue disorders, and drug-induced vasculitides (eg, propylthiouracil —see table Causes of Pulmonary-Renal Syndrome).