We found that there was a highly significant relation between high histological grading and other prognostic factors: low levels of ER (r=-0, 338; p <0, 01) and PR (r = - 0, 307; p < 0, 001), high levels of Her-2 / neu (r = 0, 165; p < 0, 05), Ki-67 (r = 0, 476; p < 0, 001), p53 (r = 0, 198; p < 0, 05), D2 - 40 (r = 0, 159; p < 0, 05) and Nottingham Prognostic Index NPI (r = 0, 367; p < 0, 001).