Purpose: To find out the relationship between Epstein-Barr virus (EBV) and nasopharyngeal carcinoma (NPC) by follow-up of IgG antibody against viral capsid antigen (VCA) of EBV in serum samples from 80 NPC patients and 80 patients with squamous cell carcinoma of the head and neck other than nasopharynx (SCCHN).