Results: After treatment with surfactant by using INSURE method 48 hours, the incidence of tachypnoea decreased from 83.3% to 4.2% (p< 0.05), taking CPAP with FiO2 > 60% decreased from 73.3% to 8.3% (p< 0.05) and with peep > 5 cmH2O decreased from 23.3% to 4.2% (p< 0.05), the respiratory acidosis and the mixed respiratory - metabolic acidosis rates decreased from 70% to 0% (p< 0.05).