Purpose: Evaluate treatment results of chemotherapy in metastatic and recurrent colon cancer at Trieu An Hospital. Methods: A retrospective study all patients was diagnosed metastatic - recurrent colon cancer and treated at the oncological department in Trieu An Hospital from 5/2005 to 5/2008.Results: Patients treated with combination chemotherapy have more overall response rate, stable desease time, time to progressive desease than single agent chemotherapy. Conclusion: Chemotherapy provided benefits in metastatic and recurrent colon cancer.