Treatment of Neonatal Hyponatremia IV 5% dextrose / 0.45% to 0.9% saline solution Rarely IV hypertonic (3%) saline solution Treatment of neonatal hyponatremia is with 5% D/0.45% to 0.9% saline solution IV in volumes equal to the calculated deficit, given over as many days as it takes to correct the sodium concentration by no more than 10 to 12 mEq / L / day (10 to 12 mmol / L / day) to avoid rapid fluid shifts in the brain.