Contraindications and Precautions Contraindications for all four COVID-19 vaccines are Severe allergic reaction after a previous dose of either vaccine Severe allergic reaction to a vaccine component Precautions for all four COVID-19 vaccines are Acute anaphylactic reaction immediately after a dose Immunocompromise, including due to immunosuppressant therapy Appropriate medical treatment to manage immediate allergic reactions must be immediately available in the event an acute anaphylactic reaction occurs after any COVID-19 vaccine is given.