Clin Rheumatol 36 (2): 463 - 468, 2017. doi: 10.1007 / s10067 - 016 - 3317 - 7 Diagnosis Clinical evaluation (1) Diagnosis of PFAPA syndrome is based on clinical findings, which include the following: ≥ 3 febrile episodes, lasting up to 5 days and occurring at regular intervals Pharyngitis plus adenopathy or aphthous ulcers Good health between episodes and normal growth Acute-phase reactants (eg, C-reactive protein, erythrocyte sedimentation rate) are elevated during a febrile episode but not between episodes.