Treatment of Leishmaniasis Drug therapy depends on the clinical syndrome and other factors For cutaneous infection, topical treatment, sodium stibogluconate injection or topical paromomycin outside the US or heat therapy or cryotherapy For systemic treatment of cutaneous, mucosal, or visceral leishmaniasis, liposomal amphotericin IV or miltefosine orally Alternatively, amphotericin B deoxycholate IV or pentavalent antimonials (sodium stibogluconate, meglumine antimoniate) IV or IM if the infecting Leishmania species is likely to be susceptible Treatment of leishmaniasis is complicated.