Gastroenterology Feb 19; S0016 - 5085 (16) 00224 - 9, 2016. doi: 10.1053 / j. gastro.2016.02.033 Treatment of Acalculous Biliary Pain Unclear but sometimes laparoscopic cholecystectomy or endoscopic sphincterotomy Laparoscopic cholecystectomy improves outcomes for patients with microscopic stones and possibly abnormal gallbladder motility.