Diagnosis of Sepsis and Septic Shock Clinical manifestations Blood pressure (BP), heart rate, and oxygen monitoring Complete blood count (CBC) with differential, electrolyte panel and creatinine, lactate Invasive central venous pressure (CVP), PaO2, and central venous oxygen saturation (ScvO2) readings Cultures of blood, urine, and other potential sites of infection, including wounds in surgical patients Sepsis is suspected when a patient with a known infection develops systemic signs of inflammation or organ dysfunction.