Findings: The results have shown that clinical lesions were diverse, especially skin lesions. The skin thickness - mRSS was 14.5 ± 7.9, Raynaud's phenomenon (73.3%), skin pigmentation disorder (53.3%), hair loss (46.7%), digital ulcers (31.7%), digital gangrene (28.3%), pitting scars (11.7%), skin ulcers (33.3%), telangiectasia (13.3), calcinosis (18, 3%).