(See also Overview of Transplantation) The most common indications for lung transplantation are Chronic obstructive pulmonary disease (COPD) Idiopathic pulmonary fibrosis Cystic fibrosis Alpha-1 antitrypsin deficiency Primary pulmonary hypertension Less common indications include other interstitial lung disorders (eg, sarcoidosis), bronchiectasis, and congenital heart disease.