Organ involvement Patients are screened for organ involvement beginning with noninvasive testing: Kidneys: Urinalysis; measurement of serum BUN, creatinine, and albumin; estimated glomerular filtration rate (eGFR); and 24-hour urine collection for protein electrophoresis (UPEP) Liver: Liver function tests Lungs: Chest x-ray, chest CT, and pulmonary function tests Heart: ECG and measurement of biomarkers such as brain (B-type) natriuretic peptide (BNP) or N-terminal-pro-BNP (NT-proBNP) and troponin Cardiac involvement can be suggested by low voltage on ECG (caused by a thickened ventricle) and / or dysrhythmias.