Arthritis Rheum 60 (6): 1851 - 1861, 2009. doi: 10.1002 / art.24569 Treatment Colchicine Sometimes canakinumab, anakinra, or rilonacept Prophylactic colchicine 0.6 mg orally 2 times a day (some patients require dosing 4 times a day; others a single daily dose) provides complete remission or distinct improvement in about 85% of patients.