Acid-Base Disorders By James L Lewis III, MD, Brookwood Baptist Health and Saint Vincent's Ascension Health, Birmingham Reviewed / Revised Jul 2021 | Modified Sep 2022 View Patient Education Classification Symptoms and Signs Diagnosis Key Points Topic Resources Henderson-Hasselbalch Equation Anion Gap Anion Gap Delta Delta Gradient... Anion Gap in Hypoalbumin... Winter's Formula for Expected.. Arterial Blood Gas Interpretation... Primary Changes and Compensations... Clinical Consequences of... Overview of Acid-Base Maps... Overview of Plasma Anion Gap Acid-base disorders are pathologic changes in carbon dioxide partial pressure (P co 2) or serum bicarbonate (HCO 3 −) that typically produce abnormal arterial pH values.