To stabilize vitamin B12 in tablets containing Vitamin B1+B6+B12, Kollidon Cl-M was used as stabililizer agent combining the dipersion of vitamin B12 in dry state before compression. Applying accelerated stability testing with storage condition of t0 = 57o C, RH=80% in 72 hours, the preliminary results showed that the use of Kollidon CL-M 2% in the formulation can improved effect on the stabilization of vitamin B12.