As a hypothetical example, a high cutoff for white blood cell (WBC) count (eg, 20, 000 / μ L) in a possible case of acute appendicitis is more specific and would have a high LR + but also a high (and thus not very informative) LR -; choosing a much lower and very sensitive cutoff (eg, 10, 000 / μ L) would have a low LR - but also a low LR +.