Treatment of Cluster Headache For aborting attacks, parenteral triptans, dihydroergotamine, or 100% oxygen For long-term prophylaxis, of episodic cluster, verapamil, lithium, topiramate, divalproex, or a combination or galcanezumab Acute attacks of cluster headache can be aborted with either a parenteral triptan or dihydroergotamine, zolmitriptan taken by nasal spray, and / or 100% oxygen given by nonrebreathing face mask.