Favorable prognostic factors are Age 3 to 9 years WBC count < 25, 000 / mcL (< 25 × 10 9 / L) or < 50, 000 / mcL (< 50 × 10 9 / L) in children Leukemic cell karyotype with high hyperdiploidy (51 to 65 chromosomes), t (1; 19), and t (12; 21) No CNS disease at diagnosis Unfavorable factors include Leukemic cell karyotype with 23 chromosomes (haploidy), with < 46 chromosomes (hypodiploidy), or with 66 to 68 chromosomes (near triploidy) Leukemic cell karyotype with t (v; 11q23) MLL (KMT2A) rearranged, including t (4; 11) / KMT2A-AF4 Leukemic cell karyotype t (5; 14) / IL3-IG Leukemic cell karyotype t (8; 14), t (8; 22), t (2; 8) C-MYC rearranged Presence of the Philadelphia (Ph) chromosome t (9; 22) BCR-ABL1 Increased age in adults BCR / ABL - like molecular signature Regardless of prognostic factors, the likelihood of initial remission is ≥ 95% in children and 70 to 90% in adults.