These observations suggest 1 of 2 possibilities: Somatic mosaicism for TSC-2 mutations within the lungs and kidneys results in foci of disease superimposed against a background of normal cells within these tissues (although multiple discrete sites of disease might be expected) LAM represents a low-grade, destructive, metastasizing neoplasm, perhaps of uterine origin, that spreads through the lymphatic system Symptoms and Signs of Lymphangioleiomyomatosis Initial symptoms of lymphangioleiomyomatosis are dyspnea and, less commonly, cough, chest pain, and hemoptysis.