Tuberous Sclerosis Complex (TSC) By M Cristina Victorio, MD, Akron Children's Hospital Reviewed / Revised Aug 2021 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Topic Resources Ash-Leaf Spots in Tuberous... Adenoma Sebaceum in Tuberous... Café-au-Lait Spot Koenen Tumors in Tuberous... International Tuberous Sclerosis... Tuberous sclerosis complex is a dominantly inherited genetic disorder in which tumors (usually hamartomas) develop in multiple organs.