IVIG is used to treat or prevent severe bacterial and viral infections, autoimmune disorders, and immunodeficiency disorders, particularly the following: Kawasaki disease HIV infection in children Chronic B-cell lymphocytic leukemia Primary immunodeficiencies Immune thrombocytopenia Prevention of graft-vs-host disease Adverse effects of IVIG are uncommon, although fever, chills, headache, faintness, nausea, vomiting, hypersensitivity, anaphylactic reactions, coughing, and volume overload have occurred.