Loop diuretics (eg, furosemide 80 to 240 mg orally twice a day) may be combined with thiazide diuretics (eg, chlorthalidone 12.5 to 100 mg orally once a day, hydrochlorothiazide 25 to 100 mg orally in 1 to 2 divided doses a day, metolazone 2.5 to 20 mg orally once a day) if hypertension or edema is not controlled.