Objectives: This study in order to investigate the acute and sub-chronic toxicity of Momordica charantia - Abelmoschus esculentus extracts on mice as well as the hypoglycemic effect on diabetic mice - induced Alloxan. Methods: This study was carried out on Albino swiss mice were given Daonil and Momordica charantia - Abelmoschus esculentus extracts on Alloxan - induced diabetic miceResults: The LD50 of Momordica charantia - Abelmoschus esculentus extracts is 120.2 g / kg body weight of mice.