Hb composition changed: β0β0, HbA1 decreased (35.7±12.2%), HbF increased (60.8±23.7%); The β0βE form has decreased HbA1 (26.1±14.1%); HbF increased (38.5±14.6%) and HbE increased (38.3±15.7%); β0β mutant, with reduced HbA1 (73.7±26.5%); HbA2 increased (3.8±1.5%), HbF increased (21.2±4.3%).