JAMA 215 (8): 762 - 774, 2016. doi: 10.1001 / jama.2016.0288 Treatment of Sepsis and Septic Shock Perfusion restored with IV fluids and sometimes vasopressors Oxygen support Broad-spectrum antibiotics Source control Sometimes other supportive measures (eg, corticosteroids, insulin) Patients with septic shock should be treated in an ICU.