Pharmacotherapy are including NSAIDs in pain relief and moderate inflammation; prednisone and methylprednisolone used to treat in the cases of CRPS are not effective by NSAIDs and severe inflammation; other drugs as β blocker, calcium channel blocker, gabapentin and calcitonin for treatment of CRPS symptoms; sulfasalazine and methotrexate used to treat CRPS cases combined with JIA.