The CA-125 level of 20.86 UI / ml, associated with a sensitivity of 70%, a specificity of 73.6%, the positive predictive value of 81.1%, and the area under the ROC curve of 0.718, was suitable for adenomyosis diagnosis. Conclusions: Serum CA-125 is a simple and non-invasive diagnostic test for, and helpful in suggesting stages especially advanced stages of, pelvic endometriosis and adenomyosis.