Liver Injury Caused by Drugs By Danielle Tholey, MD, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Mar 2023 View Patient Education Pathophysiology Diagnosis Treatment Prevention Key Points Topic Resources Potentially Hepatotoxic Drugs Many medications (eg, statins) commonly cause asymptomatic elevation of hepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase).