For meningitis or severe pulmonary disease, the standard regimen consists of the following: Amphotericin B 0.7 mg / kg IV (or liposomal amphotericin B 3 to 4 mg / kg IV) once a day plus flucytosine 25 mg orally every 6 hours for the first 2 weeks of treatment (longer induction therapy may be needed if clinical response is slow or cultures remain positive) Followed by fluconazole 400 mg orally once a day for 10 weeks total Once induction therapy is completed, long-term suppressive (maintenance) therapy (required) Repeated lumbar puncture is important to manage elevated opening pressures.