Indications for Daptomycin Daptomycin has activity against the following: Gram-positive bacteria (broad-spectrum activity) Multidrug-resistant gram-positive bacteria Daptomycin is used mainly for infections caused by Vancomycin - and methicillin-resistant Staphylococcus aureus Vancomycin - resistant enterococci However, methicillin-resistant S aureus and vancomycin - resistant enterococci may become resistant during daptomycin therapy, resulting in relapsing or persistent infection.