These disorders include Corticosteroid-resistant nephrotic syndrome (defective NPHS2 gene coding for podocin) Familial focal segmental glomerulosclerosis (defective ACTN 4 gene coding for alpha-actin 4) Denys-Drash syndrome, which is characterized by diffuse mesangial sclerosis, male pseudohermaphroditism, and Wilms tumor (defective WT1 gene)