Indications for Lefamulin Lefamulin is indicated for the treatment of community-acquired bacterial pneumonia (CABP) caused by the following susceptible microorganisms: Streptococcus pneumoniae Staphylococcus aureus Haemophilus influenzae Legionella pneumophila Mycoplasma pneumoniae Chlamydophila pneumoniae Contraindications to Lefamulin Use of lefamulin with CYP3A4 substrates that prolong the QT interval, such as tacrolimus, dofetilide, and quetiapine, is contraindicated.