Lymphangioleiomyomatosis By Joyce Lee, MD, MAS, University of Colorado School of Medicine Reviewed / Revised Jun 2021 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Lymphangioleiomyomatosis Lymphangioleiomyomatosis (LAM) is an indolent, progressive growth of smooth muscle cells throughout the lungs, pulmonary blood vessels, lymphatics, and pleurae.