The abnormal electrophysiology may be favorable to one or both of the following: Failure of impulse formation or conduction, which may lead to bradyarrhythmias Re-entry and mechanisms of abnormal automaticity, leading to tachyarrhythmias The most common genetic channelopathies are the Brugada syndrome (BrS), catecholaminergic polymorphic ventricular tachycardia (CPVT), early repolarization syndrome (ERS), idiopathic ventricular fibrillation (IVF), isolated progressive cardiac conduction disease (isolated PCCD), long QT interval syndromes (LQTS), and short QT interval syndrome (SQTS).