in PLATO trial-phase III. Methods: Tree-decision model, simulating one-year treatment of ACS by TIC or CLO based on data of PLATO trial and Markov model, simulating life-time horizon after 1-year treatment of ACS with input data, derived from PLATO trial, retrospective patients' records in 2014 - 2015 in Ho Chi Minh city (HCMC) Heart Institute, People Hospital 115, hospital of occupational diseases and rehabilitation.