Treatment of Noncholera Vibrio Infections Ciprofloxacin or doxycycline for enteric infection Antibiotics and often debridement for wound infection Noncholera Vibrio enteric infections can be treated with a single oral dose of one of the following: Ciprofloxacin 1 g Doxycycline 300 mg However, generally, such treatment is not necessary because the infection is self-limited, although treatment may be considered in severe cases.