Chronic Lymphocytic Leukemia (CLL) By Ashkan Emadi, MD, PhD, University of Maryland; Jennie York Law, MD, University of Maryland, School of Medicine Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Clinical Staging of Chronic... Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of phenotypically mature malignant B lymphocytes.