Treatment of Pain By James C Watson, MD, Mayo Clinic College of Medicine and Science Reviewed / Revised Mar 2022 | Modified Sep 2022 View Patient Education Nonopioid Analgesics Opioid Analgesics Adjuvant Analgesic Drugs Neural Blockade Neuromodulation Geriatrics Essentials Topic Resources Nonopioid Analgesics Opioid Analgesics Equianalgesic Doses of Opioid... Drugs for Neuropathic Pain Nonopioid and opioid analgesics are the main drugs used to treat pain.