Symptomatic and supportive treatment for acute reactions may include Antihistamines for pruritus Nonsteroidal anti-inflammatory drugs (NSAIDs) for arthralgias Corticosteroids for severe reactions (eg, exfoliative dermatitis, bronchospasm) Epinephrinefor anaphylaxis Conditions such as drug fever, a nonpruritic rash, or mild organ system reactions require no treatment other than discontinuation of the drug (for treatment of specific clinical reactions, see elsewhere in THE MANUAL).