J Allergy Clin Immunol 106 (6): 1147 - 1154, 2000. doi: 10.1067 / mai.2000.110471 Symptoms and Signs Symptoms and signs of hereditary and acquired angioedema are similar to those of other forms of bradykinin-mediated angioedema, with asymmetric and mildly painful swelling that often involves the face, lips, and / or tongue.