The results reported that lower HRQOL score had seen in children with a disease duration of less than 12 months, higher disease activity (≥ 11 points, as measured by SLEDAI score), two or more damaged organs, hospitalized more than three times on all four PedsQLTM4.0 Generic scales, especially in physical functioning and school functioning. Therefore, health care providers should be paying attention on HRQOL in children with SLE.