Consider the proportion of survival in vaccinated and control group which was injected with PBS+Alum instead of vaccine. Results: Vaccinated mice were healthy and survived 100 - 67% after 14 - 21 days P c. Control group that non-vaccinated succumbed within 10 days P c in proportion of survival 40 - 0% at doses 4.2 - 420 LD50/0.02ml / IN & IC Conclusion: Whole-virion inactivated purified influenza A H5N1 vaccine based on Vero cell culture gives sufficient protective efficacy in mice Balb / c when challenge with a human influenza AH5N1 virus.