ACE2 consists of a peptidase (PD) and collectrin-like domain (CLD) ending with a transmembrane-helix that has a cellular portion (~ 40 residues) in the N - and C-terminal, respectively. The ACE2 is highly localized in the epithelial cells of the lungs, heart, kidneys, blood vessels, small intestine, testes, adipose tissue and thyroid gland, and it controls vasoconstriction and blood pressure [4].