Multiple Endocrine Neoplasia, Type 2B (MEN 2B) (Mucosal Neuroma Syndrome; Multiple Endocrine Adenomatosis, Type 2B) By Lawrence S Kirschner, MD, PhD, The Ohio State University; Pamela Brock, MS, CGC, The Ohio State University Reviewed / Revised Jun 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Mucosal Neuroma Multiple endocrine neoplasia, type 2B (MEN 2B) is an autosomal dominant syndrome characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities.