Methods: Controlled clinical trial, 84 HBeAg - positive chronic hepatitis B patients were assigned into 2 groups: Group 1 was used Diep Ha Chau capsule and Lamivudine, group 2 was used pure Lamivudine in 6 months. ALT was checked every month; HBV DNA (<250 copy / ml, <3 log copy / ml, < 5 log copy / ml) and HBeAg seroconversion were followed up at three months and six months later.