Intravenous cyclophosphamide (IC) was used for treatment in a number of clinical trial studies of various researchers such as Shah (2017), Kanigicherla (2018) and Berkane (2018) and was also shown to be effective. It helped to not only improve clinical signs and symptoms and laboratory parameters but also shorten the treatment time and remain a long-term remission in children with steroid - dependent and steroid - resistant INS.