Hodgkin Lymphoma (Hodgkin's Disease) By Peter Martin, MD, Weill Cornell Medicine; John P Leonard, MD, Weill Cornell Medicine Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Hodgkin Lymphoma (Mediastinal... Reed-Sternberg Cell Histopathologic Subtypes... Lugano Staging of Hodgkin... Hodgkin Lymphoma Posttreatment... Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow.