The most appropriate model for forecasting the direct medical cost of Thalassemia treatment included age, sex, number of days in inpatient care, and comorbidities status, expressed as follows: 1-case direct medical cost=exp [14.135+ 0.255 * (≥6 years old) +0.092 * (Female) + 0.404 * (>1 day in inpatient care) + 0.449 * (had comorbidities)]).