Preferred regimens are Doxorubicin Docetaxel / gemcitabine (preferred for leiomyosarcoma) Other recommended regimens include Doxorubicin / ifosfamide Doxorubicin / dacarbazine Gemcitabine / dacarbazine Gemcitabine / vinorelbine Dacarbazine Gemcitabine Epirubicin Ifosfamide Liposomal doxorubicin Pazopanib Temozolomide Trabectedin Eribulin Overall, response to chemotherapy is poor.