Treatment of Inflammatory Bowel Disease Supportive care 5-Aminosalicylic acid Corticosteroids Immunomodulating drugs Biologic agents (anticytokine drugs) Small-molecule agents (eg, Janus kinase inhibitor, sphingosine 1-phosphate [S1P] receptor modulator) Sometimes antibiotics (eg, metronidazole, ciprofloxacin) and probiotics Several classes of drugs are helpful for IBD.