Treatment of Kaposi Sarcoma Surgical excision, cryotherapy, electrocoagulation, intralesional chemotherapy, or possibly topical imiquimod for superficial lesions Local radiation therapy and chemotherapy for multiple lesions, diffuse involvement, or lymph node disease Antiretroviral therapy with similar local treatments or chemotherapy depending on extent of disease for AIDS-associated Kaposi sarcoma Reduction of immunosuppressants for iatrogenic Kaposi sarcoma Treatments for classic and AIDS-associated Kaposi sarcoma overlap considerably.