Arteries of the heart Treatment of Coronary Artery Disease Medical therapy including antiplatelet drugs, lipid-lowering drugs (eg, statins), and beta-blockers Percutaneous coronary intervention For acute thrombosis, sometimes fibrinolytic drugs Coronary artery bypass grafting Treatment generally aims to reduce cardiac workload by decreasing oxygen demand and improving coronary artery blood flow, and, over the long term, to halt and reverse the atherosclerotic process.