Treatment of Post-LP and Other Low-Pressure Headaches Hydration and caffeine Usually an epidural blood patch The first line of treatment for post-LP headache is Recumbency Hydration An elastic abdominal binder Caffeine Analgesics as needed However, if post-LP headache persists after a day of such treatment, an epidural blood patch (injection of a few mL of the patient's clotted venous blood into the lumbar epidural space) is usually effective.