Rifampin is used with other antibiotics for Tuberculosis Atypical mycobacterial infection (rifampin is active against many nontuberculous mycobacteria, but rapidly growing mycobacteria, such as Mycobacterium fortuitum, M chelonae, or M abscessus, are naturally resistant) Leprosy (with dapsone with or without clofazimine) Staphylococcal infections, including osteomyelitis, prosthetic valve endocarditis, and infections involving foreign bodies such as a prosthetic joint (with other antistaphylococcal antibiotics) Legionella infections (older data suggest better outcomes for rifampin when used with erythromycin; use of rifampin with azithromycin or a fluoroquinolone offers no advantage) Pneumococcal meningitis when organisms are susceptible to rifampin (with vancomycin with or without ceftriaxone or cefotaxime for ceftriaxone - or cefotaxime - resistant organisms [minimum inhibitory concentration > 4 mcg / mL]) or when expected clinical or microbiologic response is delayed Rifampin can be used alone for prophylaxis of close contacts of patients with meningococcal meningitis or Haemophilus influenzae type b meningitis.