Peripheral Ulcerative Keratitis (Marginal Keratolysis; Peripheral Rheumatoid Ulceration) By Melvin I Roat, MD, FACS, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Aug 2022 | Modified Sep 2022 View Patient Education Topic Resources Keratitis (Peripheral Ulcerative) Peripheral ulcerative keratitis is inflammation and ulceration of the cornea that often occurs with chronic connective tissue diseases.