Methods: The acute toxicity was studied based on Regulation No. 371 of Ministry of Health and two experimental hepatotoxic models. These models were induced by carbon tetrachloride at dose of 0.5 g / Kg (acute disorder) and by ethanol at dose of 1.8 g / Kg (chronic disorder) using hepatic content of malondialdehyde (MDA) and glutathione as observation index.