Symptoms and signs of progeria develop within 2 years of birth and include Growth failure (eg, short stature, delayed tooth eruption) Craniofacial abnormalities (eg, craniofacial disproportion, micrognathia, beaked nose, macrocephaly, large fontanelle) Physical changes of aging (eg, wrinkled skin, balding, decreased range of motion of joints, tough skin that resembles scleroderma) Diagnosis of progeria is usually obvious by appearance but must be distinguished from segmental progerias (eg, acrogeria, metageria) and other causes of growth failure.