In atypical cases, that is, in patients who have not had preceding infection or who have recurrent disease, testing for complement factor gene mutations is recommended. Treatment of HUS Supportive care, often including hemodialysis For cases involving complement dysregulation, sometimes eculizumab or ravulizumab Typical diarrhea-associated hemolytic-uremic syndrome in children caused by enterohemorrhagic infection usually spontaneously remits and is treated with supportive care; antibiotics are not used.