- The preoperative alkalization phosphatase: in group serum alkalization phosphatase concentration less than 588 u / l is 81.2% and 78.2%; group > 588u / l is 33.3% and 31.3% (Logrank, p< 0.05) The multi-variable analysis gave four factors, these are undependen prognostic on survival: metastasis after treatment, invasive soft tissue of tumour > 3 cm, the zise of tumour > 8 cm and preoperative serum alkalization concentration are twice higher than normal befor - surgery.