Aspirin and Other Salicylate Poisoning (Salicylism) By Gerald F O'Malley, DO, Grand Strand Regional Medical Center; Rika O'Malley, MD, Grand Strand Medical Center Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points Salicylate poisoning can cause vomiting, tinnitus, confusion, hyperthermia, respiratory alkalosis, metabolic acidosis, and multiple organ failure.