Cochrane Database Sys Rev July 22, 2022. doi: 10.1002/14651858.CD013705.pub3 / full Treatment of COVID-19 Supportive care Sometimes, for mild to moderate illness with high-risk of severe disease: nirmatrelvir in combination with ritonavir; remdesivir (short course); molnupiravir For severe illness: remdesivir; dexamethasone; immunomodulators Treatment of COVID-19 depends on the severity of illness and the likelihood that the patient will develop severe disease.