Patients with evaporative keratoconjunctivitis sicca often benefit from treatment of concomitant blepharitis and associated acne rosacea with measures such as the following: For blepharitis with meibomian gland dysfunction: Gel-filled microwavable warm compresses applied for 10 to 15 minutes 1 to 2 times a week, infrared or automated heating and massaging devices, and / or systemic doxycycline 50 to 100 mg orally once or twice daily (contraindicated in pregnant or nursing patients) to help increase oil flow onto the eye surface and increase the amount and effectiveness of lipids in the tear film, thereby decreasing tear evaporation For seborrheic blepharitis: Eyelid margin scrubs and / or intermittent topical eyelid antibiotic ointments (eg, bacitracin at bedtime) Because of the variability of symptoms, validated questionnaires can help monitor response to therapy.