Lymphogranuloma Venereum (LGV) By Sheldon R Morris, MD, MPH, University of California San Diego Reviewed / Revised Jan 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Lymphogranuloma venereum (LGV) is a disease caused by 3 unique strains of Chlamydia trachomatis and characterized by a small, often asymptomatic skin lesion, followed by regional lymphadenopathy in the groin or pelvis.