We validated fragment transition & LOD of each drugs: Sidenafil (mz 475.2 → 100.2 / 283.2), LOD: 0.015ppm; Tadanafil (mz 390.1 → 268.1/262.1) LOD: 0.015 ppm; Vadernafil (mz 483.9 → 312.3/299.2), LOD: 0.07ppm; Prednisolon (mz 361 → 147/343.3), LOD: 0.075ppm; Dexamethason (mz 393.2 → 373.1/293.1); LOD: 0.02 ppm; Betamethason (mz 393.1 → 147.1/355.2) LOD: 0.075 ppm; Piroxicam (mz 330 → 266.2/146.1); LOD: 0.015 ppm; Sibutramin (mz 280.9 → 139/125.2), LOD: 0.75 ppm; Orlistate (mz 496. → 179, 2 / 114.1), LOD: 1 ppm; Phenophtalein (mz 319, 2 → 141.1/283.2), LOD: 0.01 ppm; Furosemid (mz 329.2 → 285/204), LOD: 0.01 ppm.