Table 3.16: Diagnosis value of severe sepsis and septic shock of presepsin compared with PCT and CRP at T0 Index Cut - off Sensitivity Specificity AUC KTC 95% p Presepsin (pg / ml) 495 57, 1% 78, 9% 0, 7 0, 59 - 0, 82 p < 0, 01 PCT (ng / ml) 6, 1 72, 5% 63, 9% 0, 66 0, 54 - 0, 78 p < 0, 05 CRP (mg / l) 183, 7 40% 83, 3% 0, 59 0, 46 - 0, 72 p > 0, 05 11 Figure 3.2: Values of plasma presepsin, CRP and PCT in differential diagnosis of NKN and SNK - Plasma presepsin concentration has a differential diagnostic value of severe sepsis and sept ic shock, the area under ROC 0.7 curve (p <0.01), with a cut-off of 495 pg / ml with a sensitivity of 57.1% and specificity 78.9%.