Ability to reduce DPPH, Fe3+, Cu2+ of pineapple peel through IC50 respectively index are 62.63 μg / mL, 97.72 μg / mL, 220.95 μg / mL; nhibited tyrosinase enzym activity in vitro with an IC50 is 73.13 g / mL; Inhibition of melanin production on the B16F10 cell line reached 59.37% at a concentration of 10 μg/mL.