The study results showed that the likelihood of patients at stage III-IV was higher when they were 60 years old, had syndrome B, hemoglobin concentration decreases <120 g / l, platelet count <150 G / L, abnormal white blood cell count (>10 or <4 G / L), increased lymphocyte count >3G / L, bone marrow biopsy results with marrow invasion, LDH increased >460U / l, B2M increased >2.2U / l, Ki67 index increased >30%.