There are three types of neuromyelitis optica spectrum disorder: Aquaporin-4 antibody positive (formerly known as NMO antibody positive) Myelin oligodendrocyte glycoprotein (MOG) positive Double-antibody negative (patients with this type have clinical neuromyelitis optica spectrum disorder but have neither antibody) Symptoms and Signs of NMOSD Symptoms of neuromyelitis optica spectrum disorder include visual loss, muscle spasms, paraparesis or quadriparesis, and incontinence.