Red flags The following findings are of particular concern: A mass or thickening that feels distinctly different from other breast tissue A mass that is fixed to the skin or chest wall A persistent mass Persistent breast swelling Peau d'orange (pitting, puckering, reddening, thickening, or dimpling in the skin of the breast) Scaly skin around the nipple Changes in the shape of the breast Changes in the nipple (eg, retraction) A unilateral discharge from the nipple, especially if it is bloody and / or occurs spontaneously Testing Imaging tests are used for Screening: Testing of asymptomatic women to detect early cancer Diagnosis: Evaluation of breast abnormalities (eg, masses, nipple discharge) Women should be screened for breast cancer (1).