Overview of Congenital Adrenal Hyperplasia (Adrenogenital Syndrome; Adrenal Virilism) By Andrew Calabria, MD, The Children's Hospital of Philadelphia Reviewed / Revised Aug 2022 | Modified Sep 2022 View Patient Education Congenital adrenal hyperplasia is a group of genetic disorders, each characterized by inadequate synthesis of cortisol, aldosterone, or both.