Lichen Sclerosus By Shinjita Das, MD, Harvard Medical School Reviewed / Revised Aug 2021 | Modified Sep 2022 View Patient Education Diagnosis Treatment Key Points Topic Resources Lichen Sclerosus Lichen Sclerosus (Vulvar... Lichen Sclerosus (Perianal... Lichen Sclerosus (Labial... Lichen Sclerosus (Atrophic) Lichen sclerosus is an inflammatory dermatosis of unknown cause, possibly autoimmune, that usually affects the anogenital area.