Multivariant logistic regression analysis showed the factors relating with encephalopathy: (1) Sex: male (OR=5.09; 95% Cl, 1.49 to 17.33; p = 0.009); (2) Gastrointestinal hemorrhage (OR = 6.26; 95% 1.63 to 24.07; p< 0.008); (3) High fever > 38.5o C (OR=15.96; 95% Cl, 3.25 to 78.33; p=0.001); (4) Hepatic failure (OR=37.93; 95% Cl, 2.01 to 713.4; p=0.015); (5) Hypoglycemia (OR=5.86; 95% Cl, 1.30 to 26.35; p=0.021); (6) WBC > 8000 / mm3 (OR=5.89; 95% Cl, 2.89 to 12.17; p=0.0001).