The main effects of GM-CSF are Stimulation of growth of monocyte, neutrophil, eosinophil, and basophil precursors Activation of macrophages Clinical uses of GM-CSF include Reversal of neutropenia after chemotherapy, radiation therapy, or both Macrophage colony stimulating factor (M-CSF) is produced by endothelial cells, epithelial cells, and fibroblasts.