The current definition of CRPC is generally regarded as sufficient: serum testosterone levels of less than 50ng / dl; three consecutive rise of PSA level, 1 week apart (the final PSA level reaching > 2ng / ml; PSA progression despite hormonal manipulations; antiandrogen withdrawal for at least 4 weeks for flutamide and 6 weeks for bicalutamide; and progression of clinical or bone lesions Mottet et al.2011.