Bullous Keratopathy By Melvin I Roat, MD, FACS, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Aug 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Bullous Keratopathy Bullous keratopathy is the presence of corneal epithelial bullae, resulting from corneal endothelial disease.