With the control group - healthy people and patients with dengue Healthy people and patients with dengue eligible for the study would provide an additional 02 ml of blood contained in EDTA K2 tube to quantify the relative expression level of plasma miRNA. The blood samples in EDTA K2 tube were centrifuged 5000 rounds for 15 minutes at room temperature, then aspirated the upper phase plasma to Epfendor tube, recorded the patient information and stored in the refrigerator at minus 20 degrees Celsius.