Patients and methods: 29 ASA physical status I-II patients, average 46.9 ± 1.97 yr, who underwent elective general surgery at University Medical Centre, from June to October 2007.Results: Introduced anesthetic dose of 0.20mcg / kg i. v Sufentanil, 0.42 ± 0.08 mcg / kg (0.40 - 0.50 mcg / kg) averaged overal dose of 0.42 ± 0.08 mcg / kg (0.40 - 0.50mcg / kg) Sufentanil, 5mcg / ml concentration, slow intravenous were no significant change in heart rate and mean blood pressure at several time of surgery (p<0.05).