Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) By Julia Benedetti, MD, Harvard Medical School Reviewed / Revised Apr 2022 | Modified Sep 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points Topic Resources Stevens-Johnson Syndrome (SJS) Severity-of-Illness Score... Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous hypersensitivity reactions.