Table Causes of Restrictive Cardiomyopathy Cause Examples Genetic abnormalities Fabry disease Gaucher disease Hemochromatosis Connective tissue disorders Amyloidosis Diffuse systemic sclerosis Endocardial fibroelastosis Other Carcinoid tumors Endomyocardial fibrosis (EMF) Hypereosinophilic syndrome (including Löffler syndrome) Radiation Sarcoidosis Pathophysiology of Restrictive Cardiomyopathy Endocardial thickening or myocardial infiltration (sometimes with death of myocytes, papillary muscle infiltration, compensatory myocardial hypertrophy, and fibrosis) may occur in one, typically the left, or both ventricles.