Nephrogenic Diabetes Insipidus By L Aimee Hechanova, MD, Texas Tech University Health Sciences Center, El Paso Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points Nephrogenic diabetes insipidus (NDI) is an inability to concentrate urine due to impaired renal tubule response to vasopressin (ADH), which leads to excretion of large amounts of dilute urine.