Intensive Care Med 43 (12): 1751 - 1763, 2017. doi: 10.1007 / s00134 - 017 - 4919 - 5 Prognosis for Sepsis and Septic Shock Overall mortality in patients with septic shock is decreasing and now averages 30 to 40% (range 10 to 90%, depending on patient characteristics).