Hyaluronic Acid, an important polysaccharide in the pathophysiology of the cirrhotic liver, had been evaluated as a valuable biomarker and could elevate the diagnostic value of a non-invasive assessment model in diagnosis of compensated cirrhosis. Objectives: We evaluated the diagnostic value of serum Hyaluronic acid itself and then constructed a non-invasive assessment model to diagnose compensated cirrhosis. Method: A total of 48 patients with chronic liver diseases who underwent percutaneous liver biopsy were prospectively analyzed.