The combination of an ACE inhibitor or ARB with a diuretic is an acceptable alternative, and may be preferred in patients with edema; however, the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial suggested that combining an ACE inhibitor or ARB with a long-acting dihydropyridine calcium channel blocker was superior to the combination with a thiazide diuretic [41], including among patients with diabetes [42].