Treatment of Neonatal Hypocalcemia Early onset: IV 10% calcium gluconate Late onset: Oral calcitriol or calcium Early-onset hypocalcemia ordinarily resolves in a few days, and asymptomatic neonates with serum calcium levels > 7 mg / dL (1.75 mmol / L) or ionized calcium > 3.5 mg / dL (0.88 mmol / L) rarely require treatment.