Among 03 published articles related to the thesis, 01 article was published in a high quality open access scientific journal belonging to the Q1 group and the ISI system, which clearly shows the thesis's contribution to the major. The thesis consists of 124 pages, including 2 pages of problem statement, 36 pages of overview, 16 pages of objects and methods, 31 pages of results, 36 pages of discussion, 2 pages of conclusion.