J Am Coll Cardiol 64: 851 - 860, 2014. doi: 10.1016 / j. jacc.2014.03.061 Treatment of Atherosclerosis Lifestyle changes (diet, smoking, physical activity) Drug treatment of diagnosed risk factors Antiplatelet drugs Statins, possibly angiotensin-converting enzyme (ACE) inhibitors, beta-blockers Treatment involves aggressive modification of risk factors to slow progression and induce regression of existing plaques.