The most frequent abnormalities include Intrauterine growth restriction Microcephaly Meningoencephalitis Cataracts Retinopathy Hearing loss Cardiac defects (patent ductus arteriosus and pulmonary artery stenosis) Hepatosplenomegaly Bone radiolucencies Less common manifestations include thrombocytopenia with purpura, dermal erythropoiesis resulting in bluish red skin lesions, adenopathy, hemolytic anemia, and interstitial pneumonia.