To contribute a part in finding better treatments for these patients, we research the topic: "The value of a Paclitaxel-coated drug-eluting balloon in coronary intervention in patients with in stent restenosis and small blood vessel lesion". Methods: In this prospective study about 36 patients with In Stent restenosis and small vessel lesion, treated with a new Paclitaxel-eluting balloon (3.0 μg / m2 balloon surface area).