Usual indications for chemotherapy are one or more of the following: Estrogen receptor (ER) and progesterone receptor (PR) - negative Human epidermal growth factor 2 (HER2) oncogene-positive ER / PR+ and positive lymph nodes in a premenopausal patient ER / PR+ and HER2 - with high Oncotype Dx™ score Relative reduction in risk of recurrence and death with chemotherapy or endocrine therapy is the same regardless of the clinical-pathologic stage of the cancer.