Hereditary Hemochromatosis (Primary Hemochromatosis) By James Peter Adam Hamilton, MD, Johns Hopkins University School of Medicine Reviewed / Revised Sep 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Hemochromatosis (Skin Hyperpigmen... Common Manifestations of... Overview of Hemochromatosis Hereditary hemochromatosis is a genetic disorder characterized by excessive iron (Fe) accumulation that results in tissue damage.