The hallmark of chronic Myeloid Leukemia (CML) and a subset of Acute Lymphoblastic Leukemia (ALL) is the presence of the Philadelphia chromosome as a result of the t (9; 22) translocation. This gen rearangement results in a production of a novel oncoprotein, BCR-ABL-190 and BCR-ABL-210.Diagnostic and monitoring the CML can be made by Quantitation of these 2 gens by Reverse Quantitative Polymerase Chain Reaction (QR-PCR) with Ct method.