Methods: Claisen Schmidt reaction is applied for synthesis of heterocyclic chalcone, and their anti-inflammatory activity is measured by the model of carrageenin-induced edema in hind paw of the rat. Results: 10 Polyoxychalcones were obtained with good yields and the results of in vivo anti-inflammatory activity showed that chalcones with hydroxyl group at position 2 of A ring are stronger than that of mother chalcone.