Nonhormonal medications At least 3 groups of nonhormonal medications are useful in reducing polyuria: Diuretics, primarily thiazides Vasopressin - releasing medications (eg, chlorpropamide, carbamazepine, clofibrate) Prostaglandin inhibitors These medications have been particularly useful in partial arginine vasopressin deficiency and do not cause the adverse effects of exogenous vasopressin.