Checkerboard method was used to determine type of synergic effect of combination of chalcone derivatives with antibiotics. Results: Among the six heterocyclic chalcone derivatives the compounds of F4 (1 - (pyridine-2-yl) - 3 - (3-hydroxyphenyl) - 2-propene-1-one)) and F5 (1 - (furane-2-yl) - 3 - (3-hydroxyphenyl) - 2-propen-1-one) showed potentially synergic effect with doxycylin and cefuroxim against tested Salmonella.