The positive factors effecting median OS were HFSR (14.6 months vs 5.8 months, p=0.002), stomatitis (23.8 months vs 6.7 month, p=0.045), hypertension (45.2 months vs 6.7 months, p=0.011), no elevated liver enzymes (10.4 months vs 5.9 month, p=0.028).