There hasn't been any study of characteristics, treatment and prognostic of CML in children in Vietnam. Objectives: To determine the epidemiologic, clinical and biologic features, and to evaluate the effect of Imatinib therapy in children with CML in The Blood Transfusion and Hematology Hospital, Ho Chi Minh city. Subjects and Methods: Review medical records to describe the epidemiologic, clinical and biologic features and to evaluate the effect of Imatinib therapy in 37 children with CML who were admitted to The Blood Transfusion and Hematology Hospital, Ho Chi Minh city from January 2006 to January 2011.Results: The majority of affected children are more than 10 years old at diagnosis. A male to female ratio is approximately 1.0.