Subjects and Methods: 55 pre-diabetes patients treated with diet therapy, physical exercise, using metformin 1700 mg / day for 1 year were assessed based on the glucose concentration, blood lipids, anthropometric indices, blood pressure, insulin concentration, c-peptide and insulin resistance indices including HOMA2-IR, HOMA2 -% S, HOMA2 -% B determined with the pairs of glucose-insulin, glucose - c-peptid.