Neonatal Sepsis (Sepsis Neonatorum) By Brenda L Tesini, MD, University of Rochester School of Medicine and Dentistry Reviewed / Revised Jul 2022 | Modified Sep 2022 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Prevention Key Points Neonatal sepsis is invasive infection, usually bacterial, occurring during the neonatal period.