Results: The average amount of protocol in the induction phase patients using BIS (55.2 ± 6.2) mg less than the group of patients not using BIS (67.2 ± 8.1) mg with p = 0.001, changes in pulse and blood pressure during induction of anesthesia both groups hardly changed, with a linear inverse correlation, just between BIS and protocol concentrations in the brain in the process of induction (r = - 0.53, p = 0.001), the linear regression equation BIS = 89 - 13 × Ce-propofol, sevoflurane average amount consumed in the group of patients using BIS decreased 20%, with p = 0.003.