Inheritance can be Autosomal dominant: Caused by mutations in the STAT3 (signal transducer and activator of transcription 3) gene Autosomal recessive: Appears to be caused by homozygous null mutations in TYK2 (tyrosine kinase 2) or DOCK8 (dedicator of cytokinesis 8) genes Hyper-IgE syndrome starts during infancy.