Early-switching has the same treatment efficacy with not-switching and late-switching, but helped to decrease at least 2, 71 days of IV (CI: 2, 03 - 3, 39; p < 0, 001); 30, 6% antibiotic costs (CI: 5, 9 - 55, 2; p < 0, 001); 39, 5% therapy costs (CI: 6, 8 - 72, 1%; p < 0, 001) compared to not-switching.