Treatment of Chlamydia Oral antibiotics (preferably azithromycin) Empiric treatment for gonorrhea if it has not been excluded Treatment of sex partners Uncomplicated documented or suspected chlamydial infections are treated with one of the following: A single dose of azithromycin 1 g orally Doxycycline 100 mg orally twice a day for 7 days Levofloxacin 500 mg orally once a day for 7 days Azithromycin (given as a single dose) is preferred to medications that require multiple doses over 7 days, although there is some evidence that doxycycline may be preferable for rectal chlamydia (1).