Small Intestinal Bacterial Overgrowth (SIBO) By Zubair Malik, MD, Lewis Katz School of Medicine at Temple University Reviewed / Revised Mar 2023 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points More Information Small intestinal bacterial overgrowth can result from alterations in intestinal anatomy or gastrointestinal motility, or lack of gastric acid secretion.