Results: Out of 365 study participants: men (82.2%); ≥ 60 years old (83.8%), exposed to smoke and dust was 59.7%, currently smokes 13.2%, patients in stages III and IV are 75.3%, with ≥ 3 exacerbations / year in stage IV (72.7%); adherence to treatment at stage IV (54.1%), average treatment cost / month was 441 ± 57.3 VN.