Inherited metabolic disorders are typically grouped by the affected substrate, for example: Amino acid metabolism disorders Carbohydrate metabolism disorders Fatty acid metabolism disorders Purine and pyrimidine metabolism disorders All states in the US routinely do neonatal screening of all newborns for specific inherited disorders of metabolism and other conditions, including phenylketonuria, tyrosinemia, biotinidase deficiency, homocystinuria, maple syrup urine disease, and galactosemia.