Clin Respir J 11 (6): 999 - 1005, 2017. doi: 10.1111 / crj.12453 Treatment of Pneumococcal Infections A beta-lactam, macrolide, respiratory fluoroquinolone (eg, levofloxacin, moxifloxacin), tetracycline (eg, doxycycline, omadacycline), or pleuromutilin (eg, lefamulin) If pneumococcal infection is suspected, initial therapy pending susceptibility studies should be determined by local resistance patterns.