Diffuse Esophageal Spasm (Corkscrew Esophagus) By Kristle Lee Lynch, MD, Perelman School of Medicine at The University of Pennsylvania Reviewed / Revised Mar 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Symptomatic diffuse esophageal spasm is part of a spectrum of motility disorders characterized variously by nonpropulsive contractions and hyperdynamic contractions, sometimes in conjunction with elevated lower esophageal sphincter pressure.