International criteria for diagnosis include recurrent oral ulcers (3 times in 1 year) and 2 of the following: Recurrent genital ulcers Eye lesions Skin lesions Positive pathergy test with no other clinical explanation A positive pathergy test consists of the appearance of an erythematous induration with a sterile pustule in the skin 24 to 48 hours after the insertion of a sterile needle into the skin of the forearm.