Purpose: Assess metastasis after treatment of surgery and chemotherapy combination with osteosarcoma, analysis some metastasis-related foctors. Patiens and methods: A restrospective describle study on 28 eligible patients with metastatic osteosarcoma out of 95 patients in stade II osteosarcoma are treated by surgery combinated with chemotherapy regimen consisting of Doxorubicin and Cisplatin in K hospital from 6/2000 to 9/2007.