Overall, the most common causes of excessive bleeding include Severe thrombocytopenia Excessive anticoagulation, as with warfarin, heparin, or a direct oral anticoagulant (eg, apixaban, edoxaban, rivaroxaban) Liver disease (inadequate production of coagulation factors) Table Evaluation of Excessive Bleeding History History of present illness should determine the bleeding sites, the amount and duration of bleeding, and the relationship of bleeding to any possible precipitating events, including drug exposure.