Treatment of Gonorrhea For uncomplicated infection, a single dose of ceftriaxone Concomitant treatment for chlamydial infection Treatment of sex partners For disseminated gonococcal infection (DGI) with arthritis, a longer course of parenteral antibiotics Uncomplicated gonococcal infection of the urethra, cervix, rectum, and pharynx is treated with the following: A single dose of ceftriaxone 500 mg IM (1 g IM for patients weighing ≥ 150 kg) If ceftriaxone is not available, use cefixime 800 mg orally in a single dose.