A few laboratory tests are diagnostic by themselves; they include the following: IgM antibody to hepatitis A virus (anti-HAV) for acute hepatitis A Hepatitis B surface antigen (HBsAg) for acute and / or chronic hepatitis B Antibody to hepatitis C virus (anti-HCV) and HCV-RNA for acute and / or chronic hepatitis C Antimitochondrial antibody for primary biliary cholangitis (previously called primary biliary cirrhosis) Serum ceruloplasmin (reduced) and urinarycopper (elevated) for Wilson disease Serum alpha-1 antitrypsin level and genetic testing for alpha1-antitrypsin deficiency Alpha-fetoprotein for hepatocellular carcinoma Table Tests for Liver Injury Aminotransferases Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) leak from damaged cells; thus, these enzymes are sensitive indicators of liver injury.