Less common causes of DIC include Severe tissue damage due to head trauma, burns, frostbite, or gunshot wounds Complications of prostate surgery that allow prostatic material with tissue factor activity (along with plasminogen activators) to enter the circulation Enzymes in certain snake venoms that enter the circulation, activate one or several coagulation factors, and either generate thrombin or directly convert fibrinogen to fibrin Profound intravascular hemolysis Aortic aneurysms or cavernous hemangiomas (Kasabach-Merritt syndrome) associated with vessel wall damage and areas of blood stasis Slowly-evolving disseminated intravascular coagulation typically results mainly from cancer, aneurysms, or cavernous hemangiomas.