Establish the process for the preparation of 3-pyridylacetic acid hydrochloride. Result: Built the process for synthesis of 3-pyridylacetic acid hydrochloride from initial substance nicotinic acid. Conclusion: From cheap, easily found materials in Vietnam such as nicotinic acid, ethanol, morpholin..., we synthesized 3-pyridylacetic acid hydrochloride - a necessary material for preparing of risedronate sodium which is a popular drug to prevent bone fracture and to treat osteoporosis.