After using nebulized hypertonic saline, the results of lab tests showed the improvement of NTA specimens quality: the Barlett's score ≥ 3 (80% versus 40%, p <0, 001, c2) the rate of columnar cell (84% versus 50%, p <0, 001, c2), epithelial cell (90% versus 40%, p<0, 001, c2), positive and negative-Gram bacteria stain (40% versus 5%, p=0, 002, c2).