Results: Streptococcus Pneumoniae has a high resistance rate, the MIC value exceeds the MIC resistance to penicillin G / V, amoxicillin, Macrolid, Sulfamide, Phenicol; Haemophilus influenza some antibiotics also have high sensitivity such as FQ, C3, Carbapenem; Klebsiella Pneumoniae in Nghe An and Thai Binh had ESBL birth rates of 14%, 15.8%, respectively; E coli has a high rate of resistance to penicillin group (ampincilin, amoxicillin) tetracycline group, cephalosporins (C3 and C4), moderate resistance to FQ, and high sensitivity to Capabenem, Aminoside.