Therefore, enhanced expression of ACE2 aberrantly drives two physiological processes, on the one hand, it helps intrusion of SARS-CoV-2 in the cells, on the other hand, it is helpless to safeguard against injury of lungs since the ACE2 enzyme gets degraded by the SARS-CoV-2 which collectively enhances the risk of complications and destabilizes the patient to a fatal condition (Fig. (Fig. 3) .3).