IV ketamine: Give doses over 30 to 60 seconds and titrate to patient response (sedation) as follows: Initial dose: 1 to 1.5 mg / kg IV (1 to 2 mg / kg for children) over 1 to 2 minutes Subsequent doses (after 10 minutes): 0.5 to 0.75 mg / kg IV (0.5 to 1 mg / kg for children) Use lower doses (0.25 to 0.5 mg / kg) depending on the patient's clinical status (eg, older age) or other sedation; however, note that patients may experience partial dissociation and anxiety that is sometimes severe at doses of 0.5 to 1 mg/kg.