Differential diagnosis includes the following: Lymphoma, in which multiple gastric ulcers may occur Mucosa-associated lymphoid tissue (MALT) lymphoma, with extensive infiltration of monoclonal B lymphocytes Gastrinoma (Zollinger-Ellison syndrome) with associated gastric fold hypertrophy Cronkhite-Canada syndrome, a mucosal polypoid protein-losing syndrome associated with diarrhea Various treatments have been used, including anticholinergics, antisecretory medications, and corticosteroids, but none have proved fully effective.