Neurol Res Pract 4 (1): 37, 2022. doi: 10.1186 / s42466 - 022 - 00200 - 0 Treatment of Medication Overuse Headache Medications to prevent the underlying headache disorder Withdrawal of the overused headache drug Use of rescue medications (eg, antipsychotic medications, corticosteroids, dihydroergotamine) for headache during the withdrawal period Cognitive therapy Biofeedback Education A patient with medication overuse headache can be treated in an outpatient or inpatient setting; sometimes IV medications are required.