Purpose 2: Determining changes in humoral and cellular immunity in blood of HZpatients before and after treatment. + Group of herpes zoster (including research group-RGand control group-CG of purpose 3): 62 patients with HZ onset ≤ 5 days (from skin lesions); age ≥ 18; did not use any drugs previously such as corticoid, zoster treatment drugs, are not suffering from immunodeficiency diseases or HIV / AIDS; follow the treatment process and agreed to participate in the study.