Overview of Channelopathies By L Brent Mitchell, MD, Libin Cardiovascular Institute of Alberta, University of Calgary Reviewed / Revised Jan 2023 View Patient Education Channelopathies are a group of genetic, autoimmune, or inflammatory conditions that alter cardiomyocyte ion channel function in a manner that predisposes to bradyarrhythmias or tachyarrhythmias in the absence of a structural heart disorder.