Eosinophilic Granulomatosis with Polyangiitis (EGPA) (Churg-Strauss Syndrome; Allergic Granulomatosis and Angiitis) By Alexandra Villa-Forte, MD, MPH, Cleveland Clinic Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Key Points More Information Topic Resources Cutaneous Vasculitis (Lower... Eosinophilic granulomatosis with polyangiitis is a systemic small - and medium-vessel necrotizing vasculitis, characterized by extravascular granulomas, eosinophilia, and tissue infiltration by eosinophils.