Osteosclerosis By Frank Pessler, MD, PhD, Helmholtz Centre for Infection Research Reviewed / Revised Nov 2022 View Patient Education Topic Resources Pyknodysostosis (Receding... Pyknodysostosis (Hands) Osteogenesis Imperfecta... Osteosclerosis is a type of osteopetrosis that involves abnormal hardening of bone and increased skeletal density with little disturbance of modeling; in some types, bony encroachment on the marrow cavity causes cytopenias.