Broad-spectrum antiseizure drugs (which are effective for focal-onset seizures and various types of generalized-onset seizures) include Lamotrigine Levetiracetam Topiramate Valproate Zonisamide For focal-onset seizures and generalized-onset tonic-clonic seizures, the newer antiseizure drugs (eg, clobazam, clonazepam, felbamate, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine, topiramate, zonisamide) are no more effective than the established drugs.