Symptoms and Signs of Cushing Syndrome Clinical manifestations of Cushing syndrome include Moon face with a plethoric appearance Truncal obesity with prominent supraclavicular and dorsal cervical fat pads (buffalo hump) Violaceous striae (stretch marks) Usually, very slender distal extremities and fingers Manifestations of Cushing Syndrome Cushing Syndrome (Moon Facies) This photo shows characteristic moon facies in a patient with Cushing syndrome.