A comparison between group of severe liver damage and control group showed that there were differences in female sex (OR=2.4), primary treatment of shock in province hospitals (OR=5.2), unconsciousness (OR = 18.1), severe bleeding (OR=15.1), recurrent shock (OR=2.3), high bilirubinemia (OR =12.5), acute renal injury (OR=24.7), lactic acidosis (OR= 50.1), death (OR=53.3).