Methods: This is a cross - sectional descriptive study 11 cases of severe brain injury, Glasgow Coma Scale (GCS) < 9, ICP monitoring, mean arterial pressure monitoring, mechanical ventilation, target concentration of propofol TCI for sedation is 0.5 - 1 mcg / ml continuous at department of anesthesia and critical care Nguyen Dinh Chieu hospital in Ben Tre province.