Methods: Applying trimethyltin (TMT) model for memory impairments to evaluate the effect of TX extract using Morris Water Maze (MWM) protocol and biochemical detection (acetylcholine and acetylcholinesterase). Results: Two doses of TX (30 mg / kg, và 60 mg / kg, p o x 14 days) show the protective role in impairments of learning and memory caused by TMT one dose exposure (2.4 mg / kg, i. p) by evaluation of MWM: Hidden Platform Test (p < 0.01 as compared between TMT and TX60 + TMT group); Probe Test (p < 0.01 as compared between TMT and TX30 + TMT or TX60 + TMT group); and Working Memory Test (p < 0.05 as compared between TMT and TX30 + TMT; p < 0.01 as compared between TMT and TX60 + TMT).