The major adverse toxic responses identified were hematological toxicity (anemia grad 3 and 4 28.9%, neutropenia grad 3 and 4 44.4%, and thrombocytopenia grad 3 and 4 6, 7%), gastrointestinal toxicity (nausea and vomiting 80% and diarrhea 42.2%), The complete responese rate was 84.4%.