- Significant relationship between prognosis factors and treatment result to mortality risk including: high risk base on Mayo Clinic, R-ISS III, ECOG ≥ 2, P ≥ 30%, NLR ≥ 2, 25, platelet < 150 G / L, Calci ≥ 2, 67 mmol / L, β2M ≥ 5, 5 mmol/L.