The cutoff threshold of ALP levels was 238U / l that could distinguish IS patients from control group with the area under ROC curve was 0.798; 95% confident interval: 0.651 - 0.962, p<0.01.Univariate analysis shown that individuals with elevated ALP levels had 1.72 fold increased risk of cerebral infarction compared with those with normal ALP concentrations (95% CI: 1.43 - 2.11, p<0.05).