Microdeletion and Microduplication Syndromes By Nina N Powell-Hamilton, MD, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Dec 2021 | Modified Sep 2022 View Patient Education Topic Resources Examples of Microdeletion... Microdeletion and microduplication syndromes are disorders caused by submicroscopic deletions or duplications of contiguous genes on particular parts of chromosomes.