Poor prognostic indicators at 24 to 48 hours postingestion include all of the following: pH < 7.3 after adequate resuscitation International normalized ratio (INR) > 3 Serum creatinine > 2.6 Hepatic encephalopathy grade III (confusion and somnolence) or grade IV (stupor and coma) Hypoglycemia Thrombocytopenia Acute acetaminophen toxicity does not predispose patients to cirrhosis.