Treatment of Endometrial Cancer Total hysterectomy and bilateral salpingo-oophorectomy Pelvic and para-aortic lymphadenectomy for grade 1 or 2 with deep (> 50%) myometrial invasion, for any grade 3, and for all cancers with high-risk histology Pelvic radiation therapy with or without chemotherapy for stage II or III Multimodal therapy usually recommended for stage IV (See also National Comprehensive Cancer Network (NCCN): NCCN Clinical Practice Guidelines in Oncology: Uterine Neoplasms)