Squalene at doses of 400 mg / kg / dayand 1, 200 mg / kg / dayfor 60 consecutive days have allowed the normal behavior, body weight, hematological and biochemical parameters, liver and kidney functions, morphology of liver, kidney and spleen, total plasma cholesterol content, however, HDL-C level was higher in squalene treated mices compared to control group (p < 0.05). In addition, at doses of 600 and 1, 200 mg / kg / day for 60 continuous days, squalene treated mice showed the increase in HDL-C level and HDL-C / total cholesterol ratio and the decrease in the contents of LDL-C and VLDL-C without affectingthe body and liver weights and levels of total cholesterol and triglyceride.