After 2 years follow-up, 15/59 (25.4%) were replased, 13/59 (23.7%) were died and 01 (1.7%) one case was lost to follow, the overall survival was 76.2% and the disease free survival was 69, 5%. Several side effects in reduction including: infection (40.7%), mucositis (52%), hypertransaminase (44%), nausea (30%), hypofirinogen (39%).