Painful paresthesias are usually treated with gabapentin 100 to 800 mg orally 3 times a day or pregabalin 25 to 150 mg orally twice a day; alternatives include tricyclic antidepressants (eg, amitriptyline 25 to 75 mg orally at bedtime, desipramine 25 to 100 mg orally at bedtime if amitriptyline has intolerable anticholinergic effects), carbamazepine 200 mg orally 3 times a day, as well as other antiseizure medications, and opioids.