Multivariate regression analysis of some prognostic factors of death in the study group Index p O R KTC 95% Years > 60 0, 44 1, 7 0, 43 - 6, 68 APACHE II > 22 score 0, 009 8, 4 1, 7 - 41, 9 Presepsin > 488, 1 (pg / ml) 0, 01 5, 7 1, 4 - 22, 5 SOFA > 8 score 0, 56 1, 3 0, 3 - 6, 5 Lactat > 5, 4 (mmol / L) 0, 14 2, 8 0, 7 - 11, 3 Plasma presepsin concentration and APACHE II score are independent predictors of mortality in patients with severe infections and septic shock.