Treatment of Cushing Syndrome High protein intake, and potassium administration (or potassium-sparing drugs such as spironolactone) Adrenal inhibitors such as metyrapone or ketoconazole and rarely mitotane, or newer drugs such as osilodrostat and levoketoconazole Surgery or radiation therapy to remove pituitary, adrenal, or ectopic ACTH-producing tumors Sometimes somatostatin analogs or dopamine agonists to block ACTH secretion, or the glucocorticoid receptor antagonist mifepristone Initially, the patient's general condition should be supported by high protein intake and appropriate administration of potassium.