Indications for liver transplantation include Cirrhosis (70% of transplantations in the US; 10 to 20% of these cases are attributed to hepatitis C) Fulminant hepatic necrosis (about 8%) Hepatocellular carcinoma (about 7%) Biliary atresia and metabolic disorders, primarily in children (about 3% each) Other cholestatic (eg, primary sclerosing cholangitis) and noncholestatic (eg, autoimmune hepatitis) disorders (about 8%) For patients with hepatocellular carcinoma, transplantation is indicated for 1 tumor < 5 cm or up to 3 tumors < 3 cm.