Observed parameters: Hematological parameters (red blood cells, white blood cells, platelets, hematocrit, hemoglobin), blood biochemistry parameters (transaminase AST, ALT, triglyceride, protein, creatinin, urea) and pathological examination were recorded for safety evaluation. Plasma testosterone levels, body weight, the wet weights of internal genital organs (seminal vesicles, prostate glands, testicles, levator ani muscle), and swimming time were recorded for efficacy evaluation.