Causes of Pain in the Residual Limb Causes of residual-limb pain include Postoperative surgical pain Skin infection Deep tissue infection (eg, osteomyelitis, vascular graft infection) Pressure points with or without skin breakdown Neuroma Neuropathy Bone spurs Limb ischemia Phantom pain Complex regional pain syndrome Postoperative surgical wound pain typically resolves as tissues heal, typically over 3 to 6 months.