A suggested regimen is timolol 0.5% one drop every 30 minutes for 2 doses, pilocarpine 2 to 4% one drop every 15 minutes for 2 doses, brimonidine (0.15 or 0.2%) one drop every 15 minutes for 2 doses, acetazolamide 500 mg orally initially (IV if patients are nauseated) followed by 250 mg every 6 hours, and an osmotic agent, such as oral glycerol 1 mL / kg diluted with an equal amount of cold water, mannitol 1.0 to 1.5 mg / kg IV, or isosorbide 100 g orally (220 mL of a 45% solution).