The mixture of 3-methyl-1-buthanol and decanol solution (75: 25) resulted in the permeation rate at steady state of captopril through excised rat skins was maximum with flux 559.73 ± 4.32 µg / cm2 / h, and the lag time was 3.39 ± 0.48 h. Conclusion: The present results provided evidence that mixture of 3-methyl-1-buthanol and decanol solution (3: 1) can be used as a good skin permeation enhancer for formulation of transdermal patches containing captopril.