The biological manifestations rate: hemolytic anemia 5, 5%; leukopenia <4.000 / mm3 25, 5%; lymphopenia <1.000 / mm3 49, 1%; thrombocytopenia <100.000 / mm3 16, 4%; 24-hour urine protein representing >500 mg protein/24 hours 69, 1%; ANA positivity 96, 4%; anti-dsDNA antibody positivity 89, 1%.