Portosystemic Encephalopathy By Danielle Tholey, MD, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Jan 2023 View Patient Education Etiology Pathophysiology Symptoms and Signs Diagnosis Treatment Prognosis Key Points More Information Topic Resources Clinical Stages of Portosystemic... Portosystemic encephalopathy is a neuropsychiatric syndrome that can develop in patients with liver disease.