Major risk factors for aspergillosis include Neutropenia when prolonged (typically > 7 days) Long-term high-dose corticosteroid therapy Organ transplantation (especially bone marrow transplantation with graft-vs-host disease [GVHD]) Hereditary disorders of neutrophil function (eg, chronic granulomatous disease) Aspergillus species tend to infect open spaces, such as pulmonary cavities caused by previous lung disorders (eg, bronchiectasis, tumor, tuberculosis), the sinuses, or external auditory canals (otomycosis).