This study would help identify risk factors of mortality, endeavour improving outcome patient with MODS Patient and method: We carried a case-control study from January 2005 to January 2007 in ICU of Cho ray hospital, of 116 recruited patients with MODS, 58 died patients were matched with 58 survivors based on the age (± 5 years) and underlying diseases which led to MODS Result: Mean of age was 51.93 ± 20.09, 17 patients (29.31%) were over 60 years old, sum of organs failure was 3.97±1.20, and APACHE II and SOFAscores were 30.2 ± 9.8 and 12.5 ± 3.6, respectively.