Method: We shared our clinical experience with two vitrectomy systems: the Constellation ® 25G Plus and the Accurus® 23G regarding the challenges of localized diabetic retinal detachments: bleeding, dissection of PVR, removing blood clots, iatrogenic retinal break,... Conclusion: Advancements of infusion fluidics, proportional reflux, cutter, air-fluid exchange, Edge Plus® trocar blade make the Constellation® Vision System with 25G Plus a better choice for surgery of localized diabetic retinal detachments.