Systemic antibiotics are recommended for the following: Lesions > 5 mm or < 5 mm that do not resolve with drainage Multiple lesions Evidence of expanding cellulitis Immunocompromise Patients at risk of endocarditis Fever Treatment choices include sulfamethoxazole / trimethoprim 800/160 mg to 1600/320 mg orally 2 times a day, clindamycin 300 to 600 mg orally every 6 to 8 hours, and doxycycline or minocycline 100 mg orally every 12 hours.