Our aim was to evaluate HER2 overexpression in gastric cancer and to assess the relationship between its expression and gender, age, endoscopic appearance, histopathologic tumor parameters. Materials and Methods: From 3/2010 to 01/2011, 40 patients with gastric carcinoma were tested for HER2 status by immunohistochemical staining of formalin-fixed paraffin-embedded endoscopic biopsy samples.