Lancet Neurol 15 (3): 292 - 303, 2016. doi: 10.1016/S1474 - 4422 (15) 00393 - 2 Treatment of Multiple Sclerosis Corticosteroids Immunomodulators to prevent exacerbations and delay eventual disability Baclofen or tizanidine for spasticity Gabapentin or tricyclic antidepressants for pain Supportive care Goals for treatment of multiple sclerosis include the following: Shortening acute exacerbations Decreasing frequency of exacerbations Relieving symptoms Delaying disability, particularly maintaining the patient's ability to walk Treatment of exacerbations and relapses Corticosteroids, given in brief courses, are used to treat acute onset of symptoms or exacerbations that cause objective deficits sufficient to impair function (eg, loss of vision, strength, or coordination); regimens include Methylprednisolone 500 to 1000 mg IV once a day for 3 to 5 days Less commonly, prednisone 1250 mg orally per day (eg, 625 mg orally twice a day or 1250 mg orally once a day) for 3 to 5 days Some data show that high-dose methylprednisolone (1000 mg / day for 3 consecutive days) orally or IV may have similar efficacy (1, 2).