Objectives: To determine the effects on APRI of Phyllanthus urinaria product combined with Tenofovir disoproxyl fumarate compared with Tenofovir alone in chronic hepatitis B patients Methods: Randomized controlled clinical trial on 200 chronic hepatitis B patients and had HBeAg (+); divided into 2 groups: one group used Phyllanthus urinaria - TDF combination and other group used pure TDF.