Conclusion: Helicobacter pylori eradication rate of levofloxacin containing quadruple regimen was higher than that of levofloxacin containing triple regimen in patients had failed PPI-clarithromycin-amoxicillin triple therapy Keywords: Levoflocaxin containing triple regimen, levoflocaxin containing quadruple regimen, eradication, Helicobacter pylori infection.