After 4th infusion, CI increased from 3.84 ± 2.78l / min / m2 to 4.14 ± 2.24l / min / m2; GEDVI increased from 834.67 ± 285.45ml / m2 to 856.47 ± 219.25ml / m2; SVV decreased from 13.42 ± 7.78% to 11.21 ± 6.44%.