Primary eruptions can be treated with one of the following: Acyclovir 400 mg orally 3 times a day for 7 to 10 days Valacyclovir 1 g orally every 12 hours for 7 to 10 days Famciclovir 250 mg orally 3 times a day for 7 to 10 days These drugs reduce viral shedding and symptoms in severe primary infections.