Administration of Pneumococcal Vaccine The usual dose of each vaccine is 0.5 mL IM for PCV20 0.5 mL IM for PCV13 0.5 mL IM for PCV15 0.5 mL IM or subcutaneous for PCSV23 People with asymptomatic or symptomatic HIV infection should be vaccinated as soon as possible after their diagnosis.