Indications for Clindamycin The spectrum of activity for clindamycin is similar to that of the macrolide erythromycin (see table Some Clinical Uses of Macrolides) except that clindamycin is Effective for infections due to anaerobes (particularly Bacteroides species, including Bacteroides fragilis), community-acquired methicillin-resistant Staphylococcus aureus, and macrolide-resistant, clindamycin - susceptible Streptococcus pneumoniae Not reliably active against mycoplasmas, chlamydiae, Chlamydophila species, and legionellae Aerobic gram-negative bacilli and enterococci are resistant.