Results: The proportion of natural recanalization in first week is 46.08%, blood pressure, glycemia, LDL cholesterol relate to capability of natural recanalization. NIHSS, mRS and Transcranial doppler play part in prodiagnosis patients of ischemic stroke. Conclusions: Transcranial Doppler is reliable in assessment of recanalization in ischemic stroke of middle cerebral artery and prove to be useful for noninvasive management of patients with acute ischemic stroke.