Method: perspective description. Results: Study of 4 patients who had Rituximab therapy for refractory ITP at Hematology Department of Choray Hospital, we had some following conclusions: 2 cases had a complete reponse, 1 patient had non reponse, and 1 had not been evaluated the reponse. Conclusions: Rituximab regimen for refractory ITP is effective and safe in adults.