Drug-induced immunologic platelet destruction Commonly used drugs that occasionally induce thrombocytopenia include Carbamazepine Chlorpropamide Glycoprotein IIb / IIIa inhibitors (eg, abciximab, eptifibatide, tirofiban) Heparin Hydrochlorothiazide Quinine Ranitidine Rifampin Trimethoprim / sulfamethoxazole Vancomycin Except for heparin, drug-induced thrombocytopenia occurs typically when a drug bound to the platelet or a carrier protein creates a new and "foreign" antigen, causing an immune reaction.