Primary remission rates for these regimens range from Actinomycin D regimens: 69 to 94% 5-day methotrexate regimens: 87 to 94% 8-day methotrexate - folate regimens: 74 to 93% The National Comprehensive Cancer Network guidelines (NCCN) recommends multiday methotrexate or methotrexate / folate regimens.