Review of systems should seek symptoms of possible causes, including chest pain or pressure (pulmonary embolism, myocardial ischemia, pneumonia); dependent edema, orthopnea, and paroxysmal nocturnal dyspnea (heart failure); fever, chills, cough, and sputum production (pneumonia); black, tarry stools or heavy menses (occult bleeding, possibly causing anemia); and weight loss or night sweats (cancer or chronic lung infection).