Means of OSDI score were 30.27 ± 17.59 and 10.67 ± 7.46 (p < 0.01 Mann-Whitney U) respectively in diquafosol 3% group, 26.15 ± 11.79 and 13.08 ± 9.16 (p < 0.01) respectively in sodium hyaluronate 0.1% group.