Treatment of Tularemia Streptomycin (plus chloramphenicol for meningitis) The preferred drug is Streptomycin 1 g IM every 12 hours for adults and 15 mg / kg IM every 12 hours for children for 7 to 10 days for moderate to severe disease Chloramphenicol 12.5 to 25 mg / kg IV every 6 hours or doxycycline 100 mg orally 2 times a day for 14 to 21 days is added if there is evidence of meningitis.