Inborn Metabolic Disorders Causing Hyperbilirubinemia By Danielle Tholey, MD, Sidney Kimmel Medical College at Thomas Jefferson University Reviewed / Revised Jan 2023 View Patient Education Crigler-Najjar Syndrome Dubin-Johnson Syndrome and Rotor Syndrome Gilbert Syndrome Primary Shunt Hyperbilirubinemia Hereditary or inborn metabolic disorders may cause unconjugated or conjugated hyperbilirubinemia (see Overview of bilirubin metabolism).