In IDNT, 1715 participants aged 30 to 70 years with type 2 diabetes, hypertension, urine protein excretion ≥0.9 g / day, and mean serum creatinine of 1.7 mg / dL (150 micromol / L) were randomly assigned to irbesartan (75 to 300 mg once daily), amlodipine (2.5 to 10 mg once daily), or placebo [47].