Table Treatment in DVT Prevention DVT prophylaxis can involve one or more of the following: Mechanical therapy (eg, compression devices or stockings, venous filters) Drug therapy (including low-dose unfractionated heparin, low molecular weight heparins, warfarin, fondaparinux, direct oral anticoagulants) Choice depends on patient's risk level, type of surgery (if applicable), projected duration of preventive treatment, contraindications, adverse effects, relative cost, ease of use, and local practice.