Prognosis is good for patients with Langerhans cell histiocytosis and both of the following: Disease restricted to skin, lymph nodes, or bones Age > 2 years Morbidity and mortality are increased in patients with multisystem involvement, particularly those with Age < 2 years Involvement of risk organs (the hematopoietic system, liver, or spleen) Involvement of the zygomatic, sphenoid, orbital, ethmoid, or temporal bones denotes a category of CNS risk lesions that imparts a higher risk of neurodegenerative disease in the skull and front of the face.