Other drugs that have been used in combination with miltefosine to treat Acanthamoeba encephalitis include pentamidine, sulfadiazine or trimethoprim / sulfamethoxazole, flucytosine, an azole (fluconazole, itraconazole, or voriconazole), rifampin and amphotericin B. For B mandrillaris encephalitis, miltefosine in combination with other drugs such as flucytosine, pentamidine, fluconazole, and / or sulfadiazine plus either azithromycin or clarithromycin plus surgical resection have been used.