Acquired HLH can be associated with infections (eg, Epstein-Barr virus, cytomegalovirus, or others), cancer (eg, leukemias, lymphomas), immune disorders (eg, systemic lupus erythematosus, rheumatoid arthritis, polyarteritis nodosa, sarcoidosis, progressive systemic sclerosis, Sjögren syndrome, Kawasaki disease) and can occur in kidney or liver transplant recipients.