Gigantism and Acromegaly By John D Carmichael, MD, Keck School of Medicine of the University of Southern California Reviewed / Revised Apr 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Gigantism Acromegaly Acromegaly (Facial Changes) Acromegaly (Frontal and Lateral... Acromegaly (Hand Findings) Gigantism and acromegaly are syndromes of excessive secretion of growth hormone (hypersomatotropism) that are nearly always due to a pituitary adenoma.