Therefore, this study was to assess the monitoring host and vector of plague in two provinces of Gia Lai and Dak LakCentral Highlands region in 2011 Objectives: Determine the species composition of host and vector of plague, evaluate host density, and determine the flea index which infected on plague hosts at research sites. Methods: Epidemiological cross-sectional study, study subjects are rodents and fleas collected during the investigation, research time is deployed quarterly in 2011, local research sites in 02 provinces of Gia Lai and Dak Lak.