The general characteristics of studied group: Male / Female ratio was 3/1, The average age was 33.2 ± 3.7 years old, the average time of disease was 4.2 ± 2.5 years, The proportion of patients with high disease activity was 88.9% (BASDAI ≥ 4) and 88.9% (ASDAS ≥ 2.1) at T0.