Treatment of Epididymitis Antibiotics Supportive measures Epididymitis treatment consists of bed rest, scrotal elevation (eg, with a jockstrap when upright) to decrease repetitive, minor bumps, scrotal ice packs, anti-inflammatory analgesics, and a broad-spectrum antibiotic such as ciprofloxacin 500 mg orally twice a day or levofloxacin 500 mg orally once a day for 21 to 30 days.