Treatment of Pure Autonomic Failure Symptomatic treatment Treatment of pure autonomic failure is symptomatic: Orthostatic hypotension: Volume expansion, vasopressors, and support hose are used. Sometimes fludrocortisone 0.1 to 0.4 mg orally once a day and / or alpha-adrenoreceptor stimulation with midodrine 10 mg orally 3 times a day is given, but midodrine may increase supine blood pressure more than is desirable.