Preparations of HPV Vaccine Three vaccines protect against HPV: A 9-valent vaccine that protects against HPV types 6 and 11 (which cause > 90% of visible genital warts), types 16 and 18 (which cause about 70% of cervical cancers and 90% of anal cancers), and types 31, 33, 45, 52, and 58 (which together cause 10 to 20% of cervical cancers [1]) A quadrivalent vaccine (HPV4) that protects against types 6, 11, 16, and 18 A bivalent vaccine (HPV2) that protects against types 16 and 18 Only the 9-valent vaccine is now available in the US.