The aim: is to study the effects of Dexmedetomidine on hemodynamic stability and sedation - analgesia during perioperative period for the patients undergoing coronary artery bypass graft (CABG) Method and results: we start the continuous perfusion of Dexmedetomidine in the dose at 1mg / kg / hour during 10 minutes, then maintain in the dose at 0, 2 - 0, 3 mg / kg / hour during the operation until 24 hour in postoperative.