Past medical history should seek known systemic conditions associated with defects in platelets or coagulation, particularly Severe infection, cancer, cirrhosis, HIV infection, pregnancy, systemic lupus erythematosus, or uremia Prior excessive or unusual bleeding or transfusions Family history of excessive bleeding Drug history should be reviewed, particularly use of heparin, warfarin, P2Y12 inhibitors, direct oral inhibitors of thrombin or factor Xa (eg, apixaban, edoxaban, rivaroxaban), aspirin, and NSAIDs.