Background: Skin disease is one of common diseases in people living flood area, especially West-South provinces in Vietnam; there are mycosis interdigitalis, eczema, scabies... with relatively high rate. Objectives: Survey epidemiology of skin diseases and relevant factors. Method: We conducted a cross-sectinal study in 367 people in Hong Ngu, Dong Thap province. Results: Eczematous disease rate was 45.5%, mycotic and bacterial skin infections were 21% and 12, 3% respectively.