Objective: Synthesize some novel 2-thiazolylimino-5-arylidene-4-thiazolidinones derivatives and assay them in vitro for their antibacterial and antifulgal activities. Method: .2-chloro-N - (thiazole-2-yl) acetamide was synthesized by acetylating 2-aminothiazole with chloroacetyl chloride.