Results: In the acetic acid writhing model: After 20 minutes of acetic acid 1% injection, DHLD at the dose of 450 mg / kg reduced the number of writhings without statistical significance compared to the control group; DHLD at the dose of 560 mg / kg reduced the number of writhings 48.77% compared to the control group (p <0.001); DHLD at the dose of 750 mg / kg reduced the number of writhings 57.61% compared to the control group (p <0.001).