Replacement may consist of Platelet concentrates to correct thrombocytopenia (in case of rapidly declining platelet count or platelets < 10, 000 to 20, 000 / microL [< 10 to 20 ×10 9 / L]) Cryoprecipitate to replace fibrinogen (and factor VIII) if the fibrinogen level is declining rapidly or is < 100 mg / dL (< 2.9 micromol/L).