Screening for Hepatitis C Infection People should be routinely screened for hepatitis C virus (HCV) infection at least once between the ages of 18 and 79 (see the U S.Preventive Services Task Force's 2020 Hepatitis C Virus Infection in Adolescents and Adults: Screening statement and the CDC's 2020 Recommendations for Hepatitis C Screening Among Adults—United States).