In response, there has been increased emphasis on the need to Prescribe opioid drugs in lower amounts more appropriate to the likely duration and severity of pain Promote safe storage of leftover drugs Expand prescription take-back programs User Predisposing factors in users include the following: Psychologic characteristics Circumstances and disorders Psychologic characteristics are not clearly a strong factor, although people with low levels of self-control (impulsivity) or high levels of risk-taking and novelty-seeking may have an increased risk of developing substance use disorder.