The beginning conclusion is that the responding targeted treatment after 03 months and 06 months is relatively as follows: (i) the complete response is 4, 5% and 4, 7%; (ii) the partial response is 18, 2% and 9, 5%; (iii) the stable disease is 45, 5% and 42, 9%; (iv) the progressive disease is 22, 7% and 28, 6%; (v) death is 9, 1% and 14, 3%.