Rosai-Dorfman Disease (Sinus Histiocytosis With Massive Lymphadenopathy) By Jeffrey M Lipton, MD, PhD, Zucker School of Medicine at Hofstra / Northwell; Carolyn Fein Levy, MD, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell Reviewed / Revised Dec 2021 | Modified Sep 2022 View Patient Education Rosai-Dorfman disease is a rare disorder characterized by an abnormal accumulation of histiocytes and massive lymphadenopathy, particularly in the neck and head.