Overview of Lysosomal Storage Disorders By Matt Demczko, MD, Mitochondrial Medicine, Children's Hospital of Philadelphia Reviewed / Revised Oct 2021 | Modified Sep 2022 View Patient Education More Information Topic Resources Mucopolysaccharidosis (MPS) Some Sphingolipidoses Mucolipidosis (ML) Other Lipidoses Oligosaccharidosis and Related.. Lysosomal Transport Defects Other Lysosomal Disorders Lysosomal enzymes break down macromolecules, either those from the cell itself (eg, when cellular structural components are being recycled) or those acquired outside the cell.