Secondary hypogonadism Causes of secondary hypogonadism include panhypopituitarism, hypothalamic or pituitary tumors, isolated gonadotropin deficiency, Kallmann syndrome, Laurence-Moon syndrome, isolated luteinizing hormone deficiency, Prader-Willi syndrome, and functional and acquired disorders of the central nervous system (eg, trauma, infection, infiltrative disease such as Langerhans cell histiocytosis).