Objective: Defining histopathological types of malignant epithelial tumors and determining the origin of tumors by CK7, CK20 and other immunohistochemical markers. Patients and methods: A cross-sectional study of 50 patients diagnosed carcinoma and CK7, CK20 and other immunohistochemical markers stain at Hue University of Medicine and Pharmacy Hospital from January, 2020 to December, 2020.