Thrombotic Thrombocytopenic Purpura (TTP) By David J Kuter, MD, DPhil, Harvard Medical School Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Pathophysiology Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Schistocytes (Red Blood Cell... Thrombotic thrombocytopenic purpura (TTP) is an acute, fulminant disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia.