Aspergillosis By Sanjay G Revankar, MD, Wayne State University School of Medicine Reviewed / Revised Apr 2021 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points More Information Topic Resources Aspergilloma Aspergillosis is an opportunistic infection that usually affects the lower respiratory tract and is caused by inhaling spores of the filamentous fungus Aspergillus, commonly present in the environment.