Liver Biopsy By Christina C Lindenmeyer, MD, Cleveland Clinic Reviewed / Revised Sep 2021 | Modified Sep 2022 View Patient Education Topic Resources Indications for Liver Biopsy * Liver biopsy provides histologic information about liver structure and evidence of liver injury (type and degree, any fibrosis); this information can be essential not only to diagnosis but also to staging, prognosis, and management.