The most common causes are Acute tubular necrosis Acute glomerulonephritis Nephrotoxins (including prescription and over-the-counter drugs—see Analgesic Nephropathy) Overview of Intrarenal Acute Kidney Injury VIDEO Glomerular disease reduces glomerular filtration rate (GFR) and increases glomerular capillary permeability to proteins and red blood cells; it may be inflammatory (glomerulonephritis) or the result of vascular damage due to ischemia or vasculitis.