Treatment of GPA To induce remission in life - or organ-threatening GPA, high-dose corticosteroids plus either cyclophosphamide or rituximab To induce remission in less severe GPA, corticosteroids and either methotrexate or rituximab To maintain remission, rituximab alone or another drug such as methotrexate, azathioprine, or mycophenolate mofetil (rituximab plus another of these drugs, sometimes with a low dose of a corticosteroid, if patients have multiple relapses or GPA is difficult to control) Kidney transplantation if necessary Treatment of granulomatosis with polyangiitis depends on the severity of disease.