- Mannitol appeared to be prior to NaCl3% in the first 30-minute, however, the duration of the intracranial pressure under threshold of 25 mmHg in the NaCl3% group was longer than that of the mannitol group (150 minute average in NaCl3% group vs 85 minute in mannitol group) - Both agents caused the raise in plasma osmolality as well as serum sodium, the difference was significant before and after infusion.