Heterophyiasis and Related Trematode Infections (Intestinal Fluke Infection) By Chelsea Marie, PhD, University of Virginia; William A Petri, Jr, MD, PhD, University of Virginia School of Medicine Reviewed / Revised Aug 2021 | Modified Sep 2022 View Patient Education Topic Resources Heterophyes heterophyes... Heterophyiasis is infection with the intestinal fluke Heterophyes heterophyes, which is acquired by eating infected raw or undercooked fish from freshwater or brackish water.