PFAPA Syndrome By Apostolos Kontzias, MD, Stony Brook University School of Medicine Reviewed / Revised Jan 2022 | Modified Sep 2022 View Patient Education Diagnosis Treatment PFAPA (periodic fevers with aphthous stomatitis, pharyngitis, and adenitis) syndrome is a periodic fever syndrome that typically manifests between ages 2 years and 5 years; it is characterized by febrile episodes lasting 3 to 6 days, pharyngitis, aphthous ulcers, and adenopathy.