Hereditary Spastic Paraplegia By Michael Rubin, MDCM, New York Presbyterian Hospital-Cornell Medical Center Reviewed / Revised Feb 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Hereditary spastic paraplegia is a group of rare hereditary disorders characterized by progressive, spinal, nonsegmental spastic leg paresis, sometimes with intellectual disability, seizures, and other extraspinal deficits.