Treatment of Syphilis Benzathine penicillin G for most infections Aqueous penicillin for ocular syphilis or neurosyphilis Treatment of sex partners The treatment of choice in all stages of syphilis and during pregnancy is The sustained-release penicillin benzathine penicillin (Bicillin L-A) The combination of benzathine and procaine penicillin (Bicillin C-R) should not be used.