Treatment of Rosacea Avoidance of triggers Consideration of topical or oral antibiotics or topical azelaic acid or ivermectin For flushing or persistent erythema, consideration of topical brimonidine or oxymetazoline For recalcitrant cases, consideration of oral isotretinoin For rhinophyma, consideration of dermabrasion, laser ablation, and tissue excision For telangiectasia, consideration of laser or electrocautery treatment Primary initial treatment of rosacea involves avoidance of triggers (including use of sunscreen).