Other traditional antiemetics, including phenothiazines (eg, prochlorperazine 10 mg IV every 8 hours, promethazine 12.5 to 25 mg orally or IV every 8 hours) and metoclopramide 10 mg orally or IV given 30 minutes before chemotherapy with repeated doses every 6 to 8 hours, are alternatives restricted to patients with mild to moderate nausea and vomiting.