Renal concentrating capacity is lost in Older people People with diabetes insipidus, certain kidney disorders, hypercalcemia, severe salt restriction, chronic overhydration, or hyperkalemia People who ingest ethanol, phenytoin, lithium, demeclocycline, or amphotericin B People with osmotic diuresis (eg, due to high-protein diets or hyperglycemia) Other obligatory water losses are mostly insensible losses from the lungs and skin, averaging about 0.4 to 0.5 mL / kg / hour or about 650 to 850 mL / day in a 70-kg adult.