Treatment of Meconium Ileus Radiographic contrast enema Sometimes surgery Obstruction may be relieved in uncomplicated cases (ie, without perforation, volvulus, or atresia) by giving ≥ 1 enema with a dilute radiographic contrast medium (eg, gastrografin) sometimes with N - acetylcysteine under fluoroscopy; hypertonic contrast material may cause large gastrointestinal water losses requiring IV rehydration.