To meet the DSM-5 criteria for diagnosis, patients must have marked, persistent (≥ 6 months) fear of or anxiety about ≥ 2 of the following situations: Using public transportation Being in open spaces (eg, parking lot, marketplace) Being in an enclosed place (eg, shop, theater) Standing in line or being in a crowd Being alone outside the home Fear must involve thoughts that escape from the situation might be difficult or that patients would receive no help if they became incapacitated by fear or a panic attack.