Mild increases (< 300 IU / L) are nonspecific and often present in disorders such as Cirrhosis Chronic viral hepatitis Nonalcohol-related fatty liver disease (NAFLD) Cholestatic liver disorders Hepatocellular cancer, cholangiocarcinoma, and hepatic metastatic cancer Alcohol-related liver disease and alcoholic hepatitis Aminotransferases can be mildly elevated or even normal in certain liver disorders, such as Hemochromatosis Drug-induced liver disease (such as methotrexate - or amiodarone - induced liver injury) Chronic hepatitis B and chronic hepatitis C NAFLD Infiltrative liver disorders (eg, hepatic sarcoidosis, amyloidosis) Alpha-1 anti-trypsin deficiency Primary biliary cholangitis Primary sclerosing cholangitis Elevated ALT is somewhat specific for liver injury.