Background: Topical products originated from chemicals may cause side effects such as skin atrophy and tawing skin when used for long term treatments. Natural products have been increasingly studied and used since their effectiveness and safety. Objective: To evaluate the anti - inflammatory activity of trial creams containing chamomile essential oil and chitosan sourced from the local markets in order to identify a cream having good pharmacological activity. Method: This study used the model of induced edema in hind paw of the rat with 2% formalin solution to evaluate the anti - inflammatory activities of the trial creams.