Typical causes include Excessively worn teeth or dentures that do not adequately separate the jaws, creating skin folds at the corners of the mouth in which saliva accumulates Candida species (or sometimes Staphylococcus aureus) Iron deficiency, vitamin B complex deficiency (especially riboflavin, cobalamin) Treatment of angular cheilitis may involve replacing dentures or restoring proper tooth size with partial dentures, crowns, or implants, which helps reduce the folds at the corners of the mouth, and using antifungals (eg, clotrimazole cream), antibiotics (eg, mupirocin ointment), or iron or vitamin B supplementation as needed.