Hemolytic-Uremic Syndrome (HUS) By David J Kuter, MD, DPhil, Harvard Medical School Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Pathophysiology Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Schistocytes (Red Blood Cell... Hemolytic-uremic syndrome (HUS) is an acute, fulminant disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury.