Dose is lowered if potassium is between 5.0 and 5.5 mEq / L (5.5 mmol / L) and stopped if potassium is > 5.5 mEq / L (5.5 mmol / L), if creatinine increases above 2.5 mg / dL (220 micromol / L), or if ECG changes of hyperkalemia are present.