Results: 17 patients expressing TEL / AML1 (9.5%), 16 patients expressing BCR / ABL (8.9%), 5 patients expressing MLL / AF4 (2.8%), và 8 patients expressing E2A / PBX1 (4.5%) among 179 newly diagnosed patients with ALL Conclusion: RT-PCR is simple and highly sensitive technique that should apply to detect the frequent chromosome translocations not only in ALL but also in other hematologic malignancies in hematology centers in Vietnam.