Treatment of Molluscum Contagiosum Physical removal: Curettage, cryosurgery, laser therapy, or electrocautery Topical irritants (eg, trichloroacetic acid, cantharidin, tretinoin, tazarotene, podophyllotoxin [podofilox]) Sometimes intralesional injection or photodynamic therapy Sometimes combination therapies Most lesions spontaneously regress in 1 to 2 years, but they can remain for 2 to 3 years.