To reduce the time levodopa is taken and thus minimize these effects, clinicians can consider treating younger patients who have mild disability with the following drugs first: MAO-B inhibitors (selegiline, rasagiline) Dopamine agonists (eg, pramipexole, ropinirole, rotigotine) Amantadine (which is also the best option when trying to decrease peak-dose dyskinesias) However, if these drugs do not sufficiently control symptoms, clinicians should promptly initiate levodopa because it can usually greatly improve quality of life.