Treatment of PLMD and RLS For RLS: Pramipexole, ropinirole, a rotigotine patch, or gabapentin enacarbil, plus iron supplements if ferritin is < 50 ng / mL For PLMD: Usually the same treatments as for RLS For restless legs syndrome and periodic limb movement disorder, numerous drugs (eg, dopaminergic drugs, benzodiazepines, antiseizure drugs, vitamins and minerals) are used.