Methotrexate (15 to 20 mg orally or subcutaneously once a week), azathioprine (2 mg / kg orally once a day), or mycophenolate mofetil (1 to 1.5 grams orally twice a day) can be added to hydroxychloroquine in patients with uncontrolled mild to moderate disease who would otherwise be candidates for a course of corticosteroids.