Drug Treatment of Bipolar Disorders By William Coryell, MD, University of Iowa Carver College of Medicine Reviewed / Revised Aug 2021 | Modified Sep 2022 View Patient Education Drug Selection and Use Lithium Anticonvulsants Antipsychotics Antidepressants Precautions During Pregnancy Topic Resources Antidepressants Drug Selection and Use Choice of drug treatment for bipolar disorders can be difficult because all drugs have significant adverse effects, drug interactions are common, and no drug is universally effective.