Complications of Reye syndrome Complications include Electrolyte and fluid disturbances Increased intracranial pressure Diabetes insipidus Syndrome of inappropriate ADH secretion Hypotension Arrhythmias Bleeding diatheses (especially gastrointestinal) Pancreatitis Respiratory insufficiency Hyperammonemia Aspiration pneumonia Poor temperature regulation Uncal herniation and death Diagnosis of Reye Syndrome History and physical examination consistent with encephalopathy and hepatic dysfunction Blood tests for liver function, electrolytes, and ammonia level Head CT or MRI, sometimes cerebral spinal fluid evaluation Liver biopsy Reye syndrome should be suspected in any child exhibiting the acute onset of an encephalopathy (without known heavy metal or toxin exposure) and pernicious vomiting associated with hepatic dysfunction.