Recurrences are common, and empiric oral maintenance therapy with antiherpetic drugs such as acyclovir 400 mg orally every 12 hours, famciclovir 250 mg orally every 12 hours, or valacyclovir 1000 mg orally every 24 hours can be attempted if symptoms recur more than 5 times / year and HSV association is suspected or if recurrent erythema multiforme is consistently preceded by herpes flares.