The effectiveness of moderate and severe psoriasis concomitant with metabolic syndrome treatment by the combination of methotrexate and metformin: - In methotrexate+metformin group, the proportion of good, moderate and medium results were 51, 6%, 24, 2%, 24, 2%, respectively and PASI decrement was 73, 82% (19, 1 - 5), which was compatible to the results of methotrexate only group in which 42, 5%, 33, 3% and 24, 2% of patients achieved good, moderate and medium results, respectively and PASI was reduced 68, 84% (19, 9 - 6, 2).