Polysaccharides from Calocybe indica demonstrated appreciable antioxidant potential on total antioxidant activity (The content of antioxidants in terms of Calocybe indica is 38.43±0.32 mGA / g or 27.82±0.14 mAs / g) and DPPH radical scavenging activity (IC50 = 438, 52 µg / mL).