Methods: Retrospective study in 215 patients who occurred ADRs in Tropical Diseases department, Cho Ray Hospital from 01/01/2012 to 31/12/2012.Result: 215 patients occurred ADRs, including the antiinflammatory drugs 7.9%, antibiotics 7.4%, Allopurinol 7.0%, anticonvulsants 2.8%, antituberculous drugs and contrast medium drugs the same 1.8%, not clearly defined group of drugs 71.3% The severity of the reaction: life-threatening accounted for 10.7%, hospitalization or prolongation of hospitalization such as Stevens Johnson syndrome or Lyell 34.0% and other adverse reactions 55.3%.