Hyper-IgE Syndrome (Hyperimmunoglobulinemia E Syndrome; Buckley Syndrome) By James Fernandez, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University Reviewed / Revised Jan 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Hyper-IgE syndrome is a hereditary combined B - and T-cell immunodeficiency characterized by recurrent staphylococcal abscesses of the skin, sinopulmonary infections, and severe pruritic eosinophilic dermatitis.