A brain tumor should be considered in patients with any of the following: Progressive focal or global deficits of brain function New-onset seizures Persistent, unexplained, recent-onset headaches, particularly if worsened by sleep Evidence of increased intracranial pressure (eg, papilledema, unexplained vomiting) Pituitary or hypothalamic endocrinopathy Similar findings can result from other intracranial masses (eg, abscess, aneurysm, arteriovenous malformation, intracerebral hemorrhage, subdural hematoma, granuloma, parasitic cysts such as neurocysticercosis) or ischemic stroke.