Progestogens (eg, medroxyprogesterone acetate 10 mg orally once a day or depot 150 mg IM once a month, megestrol acetate 10 to 20 mg orally once a day, progesterone 300 mg nightly) are sometimes used alone to relieve hot flushes when estrogen is contraindicated, but they are not as effective as estrogen for hot flushes and do not relieve vaginal dryness.