Prevention of Alzheimer Disease Preliminary, observational evidence suggests that risk of Alzheimer disease may be decreased by the following: Continuing to do challenging mental activities (eg, learning new skills, doing crossword puzzles) well into old age Exercising regularly Controlling hypertension Lowering cholesterol levels Consuming a diet rich in omega-3 fatty acids and low in saturated fats Drinking alcohol in modest amounts However, there is no convincing evidence that people who do not drink alcohol should start drinking to prevent Alzheimer disease.