In order to expand the application, and enhance the therapeutic effects of rutin, the preparation of rutin tablets having a high bioavailability is needed Objectives: The aim of this study was to prepare a complex of rutin and 2-O-hydroxypropyl-β-cycodextrin (RHPBCD), then formulate the tablets containing this complex with a high dissolution rate. Methods: Prepared RHPBCD complex by different methods, characterized this complex via its solubility, dissolution rate, IR spectrum and differential thermal analysis (DSC). Results: The solubility of rutin in RHPBCD complex prepared by dry mixing, keading method was higher than the that of rutin material.