Prevention of Neonatal Sepsis Neonates who appear well may be at risk of group B streptococcus infection. The Centers for Disease Control and Prevention (CDC) and the American Academy of Pediatrics (AAP) currently recommend managing these infants depending on several factors (1, 2), including Presence of chorioamnionitis Whether maternal group B streptococcus prophylaxis was indicated and given appropriately Gestational age and the duration of membrane rupture If there is neither chorioamnionitis nor indication for group B streptococcus prophylaxis, no testing or treatment is indicated.