Contraindications and Precautions of Poliomyelitis Vaccine The main contraindication for IPV is A severe allergic reaction (eg, anaphylaxis) after a previous dose of the vaccine or to a vaccine component The main precautions with IPV are Moderate or severe acute febrile illness (vaccination is postponed until the illness resolves) Pregnant women who are not at increased risk of polio (they should not be given the polio vaccine even though there is no evidence that the vaccine harms pregnant women or their fetus; however, if pregnant women are at increased risk of exposure to poliovirus and require immediate protection, IPV can be given) Administration of Poliomyelitis Vaccine The IPV dose is 0.5 mL IM or subcutaneous.