Materials and Methods: Using fluorescence in situ hybridization (FISH) and reverse transcriptase - polymerase chain reaction (RT-PCR) techniques to detect t (15; 17) and PML / RARA in 99 patients with diagnosis of acute myeloid leukemia (AML) type M3 (AML-M3) or suspect AML-M3 based on HLA-DR negative from 01/2012 to 04/2015.