When fungi disseminate from a primary focus in the lung, the manifestations may be characteristic, as for the following: Cryptococcosis: Usually, chronic meningitis Progressive disseminated histoplasmosis: Generalized involvement of the reticuloendothelial system (liver, spleen, bone marrow) Blastomycosis: Single or multiple skin lesions or involvement of the central nervous system, bone, or prostate Coccidioidomycosis: Bone and joint infections, skin lesions, and meningitis Diagnosis of Fungal Infections Cultures and stains Histopathology Serologic tests (mainly for Aspergillus, Blastomyces, Candida, Coccidioides, Cryptococcus, and Histoplasma) Molecular diagnostics If clinicians suspect an acute or a chronic primary fungal infection, they should obtain a detailed travel and residential history to determine whether patients may have been exposed to certain endemic mycoses, perhaps years previously.