In platelet dysfunction or thrombocytopenia caused by decreased production, transfusions, thrombopoietin (TPO) - receptor agonists (eg, romiplostim, eltrombopag, avatrombopag), or antifibrinolytic drugs (eg, aminocaproic acid, tranexamic acid) are reserved for patients with Active bleeding Severe thrombocytopenia (eg, platelet count < 10, 000 / mcL [< 10 × 10 9 / L) A need for an invasive procedure In thrombocytopenia caused by platelet destruction, transfusions are reserved for life-threatening, central nervous system or ocular bleeding.