Chédiak-Higashi Syndrome (Chédiak-Higashi's Syndrome) By James Fernandez, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University Reviewed / Revised Jan 2023 View Patient Education Symptoms and Signs Diagnosis Treatment Chédiak-Higashi syndrome is a rare, autosomal recessive immunodeficiency disorder characterized by impaired lysis of phagocytized bacteria, resulting in recurrent bacterial respiratory and other infections and oculocutaneous albinism.