Histoplasmosis By Sanjay G Revankar, MD, Wayne State University School of Medicine Reviewed / Revised Apr 2021 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Histoplasmosis Histoplasmosis is a pulmonary and hematogenous disease caused by Histoplasma capsulatum; it is often chronic and usually follows an asymptomatic primary infection.