Options include EMA / EP (etoposide / methotrexate / actinomycin D / etoposide / cisplatin) Paclitaxel / etoposide alternating with cisplatin / etoposide Multiday etoposide / cisplatin regimens High-dose chemotherapy with stem cell support Programmed death receptor 1 (PD-1) is present in almost all gestational trophoblastic disease lesions.