Treatment of MCTD Nonsteroidal anti-inflammatory drugs (NSAIDs) or antimalarials (eg, hydroxychloroquine, chloroquine) for mild disease Corticosteroids and other immunosuppressants (eg, methotrexate, azathioprine, mycophenolate mofetil) for moderate to severe disease Calcium channel blockers (eg, nifedipine) and sometimes phosphodiesterase inhibitors (eg, tadalafil) for Raynaud syndrome General management and initial drug therapy are tailored to the specific clinical problem and are similar to those of SLE or the dominant clinical phenotype.