Leptospirosis By Larry M Bush, MD, FACP, Charles E Schmidt College of Medicine, Florida Atlantic University; Maria T Vazquez-Pertejo, MD, FACP, Wellington Regional Medical Center Reviewed / Revised Nov 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Prevention Key Points Leptospirosis is an infection caused by one of several pathogenic serotypes of the spirochete Leptospira.