20 Prognostic mortality value of presepsin in patients with severe sepsis and septic shock: When analyzing the area under the ROC curve, the plasma presepsin at T0 was capable of predicting mortality fairly in patients with severe sepsis and septic shock, with an area under the ROC curve 0.77 (p <0.001).), at cut-off 488.1 pg / ml, sensitivity is 73.9% and specificity is 70.2% (table 3.22).