Fluoroquinolones By Brian J Werth, PharmD, University of Washington School of Pharmacy Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Pharmacokinetics Indications Contraindications Use During Pregnancy and Breastfeeding Adverse Effects Dosing Considerations Topic Resources QT Interval Correction (EKG) Mechanisms of Action: Nucleic... Fluoroquinolones Some Clinical Uses of Fluoroquino... Fluoroquinolones exhibit concentration-dependent bactericidal activity by inhibiting the activity of DNA gyrase and topoisomerase, enzymes essential for bacterial DNA replication.