Materials and Methods: Constructing quantitative process of granule produced from Hibiscus using Shimadzu 8A HPLC system, C18 Kyatech column (250 x 4.6 mm, 5 μm), solvent system: CH3CN - H3PO4 0.35% (12: 78), flow rate: 0.7 ml / min, wavelength: 528 nm, sample injection volume: 20 μl.