+ Regarding TCD4/TCD8 ratio: Similar to the studies of Herrod (1983) and Lama (2002) which showed that there was changes in the ratio of TCD4+ / TCD8 + in bloodstream of patients with primary nephrotic syndrome, with a decrease in TCD4+ count, an increase in TCD8+ count and natural killer (NK) cells count. As a result, there was a decline in the ratio of TCD4+ / TCD8+ compared to normal values.