Cholelithiasis By Christina C Lindenmeyer, MD, Cleveland Clinic Reviewed / Revised Sep 2021 | Modified Sep 2022 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Prognosis Treatment Key Points Topic Resources Abdominal Imaging (Gallstones) Overview of Gallstones Cholelithiasis is the presence of one or more calculi (gallstones) in the gallbladder.