Significant adverse effects include Increased mortality in patients with pre-existing moderate / severe renal impairment (creatinine clearance ≤ 50 mL / minute) who were treated with telavancin for hospital-acquired bacterial pneumonia / ventilator-associated bacterial pneumonia versus vancomycin A histamine-mediated pruritus and flushing of the face, neck, and shoulders, similar to vancomycininfusion reaction.