Slowly evolving DIC Slowly evolving DIC produces Mild thrombocytopenia Normal to minimally prolonged PT (results are typically reported as international normalized ratio [INR]) and PTT Normal or moderately reduced fibrinogen level Increased plasma D-dimer level Because various disorders stimulate increased synthesis of fibrinogen as an acute-phase reactant, a declining fibrinogen level on 2 consecutive measurements can help make the diagnosis of DIC.