Liddle Syndrome By L Aimee Hechanova, MD, Texas Tech University Health Sciences Center, El Paso Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Diagnosis Treatment More Information Liddle syndrome is a rare hereditary disorder involving increased activity of the epithelial sodium channel (ENaC), which causes the kidneys to excrete potassium but retain too much sodium and water, leading to hypertension.