Patients and methods: 116 patients with chronic gastritis and Helicobacter pylori infection were treated with modified sequential regimen based on levofloxacin. This regiment included amoxicillin 500 mg and rabeprazole 20 mg bid for the first 5 days followed by levofloxacin 500 mg, tinidazol 500 mg and rabeprazol 20 mg bid for remaining 5 days-all drugs given twice daily.