Key Points Brugada syndrome is a genetic disorder causing characteristic ECG changes and an increased risk of ventricular arrhythmias causing syncope and sometimes sudden cardiac death at a relatively young age Risk factors for symptomatic arrhythmias include fever, and numerous drugs, including alcohol Diagnosis is by ECG, sometimes with provocative testing An implantable cardioverter-defibrillator may be required More Information The following English-language resource may be useful.