Anticoagulants are recommended for patients after ACS with concomitant: Atrial fibrillation and high thromboembolic risk (eg, CHA2DS2-VASc score of ≥ 2) Mechanical heart valves Venous thromboembolism Hypercoagulable disorders It also is reasonable to give anticoagulants to patients with STEMI and asymptomatic confirmed LV mural thrombi.