Patients without comorbidities had a safe and reasonable rate of drug use 5.83 times higher than patients with comorbidities, patients with 3 - 6 prescriptions used drugs safely and appropriately. 4.41 times higherthan patients with prescription drugs of ≥7 drugs, patients assigned to prednisolone used drugs safely and reasonably 12.50 times higher than patients assigned to methylprednisolone with p <0.05.