MTHFR rs1801133gene polymorphism: the percentage of CC / CT / TT genotype is 69.5/27.8/2.7; the percentage of C / T allele is 83.4/16.6.LRP5 rs41494349gene polymorphism: the percentage of genotype AA / AG / GG is 83.4/15.7/0.9; the percentage of A / G allele is 91.3/8.7.