Treatment of Cystic Fibrosis Comprehensive, multidisciplinary support Antibiotics, inhaled drugs to thin airway secretions, and physical maneuvers to clear airway secretions Inhaled bronchodilators and sometimes corticosteroids for responders Usually pancreatic enzyme and vitamin supplementation High-calorie diet (sometimes requiring supplemental enteral tube feedings) In patients with specific variants, CFTR modulators consisting of a CFTR potentiator or combination of CFTR correctors and a CFTR potentiator Comprehensive and intensive therapy should be directed by an experienced physician working with a multidisciplinary team that includes other physicians, nurses, dietitians, physical and respiratory therapists, mental health professionals, pharmacists, and social workers.