Focal lymphadenitis is prominent in the following: Streptococcal infection Tuberculosis or nontuberculous mycobacterial infection Tularemia Plague Cat-scratch disease Primary syphilis Lymphogranuloma venereum Chancroid Genital herpes simplex Multifocal lymphadenitis may occur in patients with the following: Infectious mononucleosis Cytomegalovirus infection Toxoplasmosis Brucellosis Secondary syphilis Disseminated histoplasmosis Symptoms and Signs of Lymphadenitis Lymphadenitis typically causes pain, tenderness, and lymph node enlargement.