The following may be used: Aspirin 100 to 325 mg within 48 hours of stroke onset Dual antiplatelet therapy: Aspirin plus clopidogrel (eg, 300 to 600 mg orally once, then 75 mg orally once a day) within 24 hours of stroke onset for patients at high risk of a transient ischemic attack (TIA, ABCD2 score ≥ 4) or minor stroke Aspirin given within 48 hours reduces the risk of early recurrent stroke and death (7).