Etiology Risk factors for pressure injury include the following: Age > 65 (possibly due to reduced subcutaneous fat and capillary blood flow) Decreased mobility (eg, due to prolonged hospital stay, bed rest, spinal cord injury, sedation, weakness that decreases spontaneous movement, and / or cognitive impairment) Exposure to skin irritants (eg, due to urinary incontinence and / or fecal incontinence) Impaired capacity for wound healing (eg, due to undernutrition; diabetes; impaired tissue perfusion due to peripheral arterial disease; immobility; venous insufficiency) Impaired sensation Pressure injury has also been reported in children with severe neurologic impairments such as spina bifida, cerebral palsy, and spinal cord injury.