However, the rate of vaginal delivery within 24 hours in Oxytocin group was higher than in Misoprostol group with p=0.01 and the rate of contraction disorders in Misoprostol group (20.3%) was significantly higher than in Oxytocin group (2.7%) with p<0.0001.Conclusions: Labor induction by Oxytocin infusion is more effective than by sublingual Misoprostol in term pregnancies with premature rupture of the membranes.