Primary Aldosteronism (Conn Syndrome) By Ashley B Grossman, MD, University of Oxford; Fellow, Green-Templeton College Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Distinguishing Primary and... Primary aldosteronism is aldosteronism caused by autonomous production of aldosterone by the adrenal cortex (due to hyperplasia, adenoma, or carcinoma).