Objective: To evaluate the efficacy of a regimen of vaginal Misoprostol in causing the complete expulsion of first-trimester missed abortions. Design: A clinical trial (non-randomized controlled trial). Methods: From May 2008 to April 2009, 196 women with a transvaginal ultrsound diagnosis of a first-trimester missed abortion ( 12 weeks) and no more than slight vaginal bleeding were consecutively enrolled.