Genetic testing for polycystic kidney disease (PKD) mutations is currently reserved for any of the following: Patients with suspected PKD and no known family history Patients with inconclusive results on imaging Younger patients (eg, age < 30, in whom imaging results are often inconclusive) in whom the diagnosis must be made (eg, a potential kidney donor) Genetic counseling is recommended for 1st-degree relatives of patients with ADPKD.