Indications Myocardial perfusion imaging is used with stress testing to Evaluate patients with chest pain of uncertain origin Determine the functional significance of coronary artery stenosis seen on angiography Determine the functional significance of collateral vessels seen on angiography Evaluate the success of reperfusion interventions (eg, coronary artery bypass grafting [CABG], percutaneous intervention, thrombolysis) Estimate prognosis after myocardial infarction After acute myocardial infarction, myocardial perfusion imaging can help estimate prognosis because it can show extent of the perfusion abnormality due to acute myocardial infarction, extent of scarring due to previous infarcts, and residual peri-infarct or other areas of reversible ischemia.