Risk of opioid use disorder depends on frequency of use and dose (3): 0.004%: No regular opioid use 0.7%: Use of low-dose opioids (< 36 mg / day OMME) 6.1%: Use of high-dose opioids (> 120 mg / day OMME) 2 to 15%: In other studies (not stratified by dose) When considering prescribing opioid therapy, particularly long-term therapy, clinicians should evaluate patients for risk factors for abuse and diversion and counsel them against intentional and inadvertent misuse.