Drugs that inhibit brain cyclooxygenase effectively reduce fever: Acetaminophen 650 to 1000 mg orally every 6 hours Ibuprofen 400 to 600 mg orally every 6 hours The daily dose of acetaminophen should not exceed 4 g to avoid toxicity; patients should be warned not to simultaneously take nonprescription cold or flu remedies that contain acetaminophen.