Cephalosporins have the following limitations: Lack of activity against enterococci Lack of activity against methicillin-resistant staphylococci (except for ceftaroline and ceftobiprole) Lack of activity against anaerobic gram-negative bacilli (except for cefotetan and cefoxitin) First-generation cephalosporins These drugs have excellent activity against Gram-positive cocci Oral 1st-generation cephalosporins are commonly used for uncomplicated skin and soft-tissue infections, which are usually due to staphylococci and streptococci.