ABSTARCTBackground: We present the early experience in intravenous thrombolysis in People's 115 Hospital. Aim: To assess the safety and feasibility of intravenous thrombolysis in the treatment of acute ischemic stroke (IS) in Vietnamese population. Methods: A prospective study of consecutive patients treated with intravenous tPA with a treatment protocol similar to that of the National Institute of Neurological Disorders and Stroke (NINDS) trial.