Result: 177 patients, male: 88.7%, female: 11.3%, mean age: 55.7 ± 10.2 years old, average dose of propranolol: 40.2 ± 64mg, 75.7% of regular using drug, mainly patients quit drug by themselves (83.3%), reaching the treatment target: 27.1%, failure to reach treatment target: 72.9%, the average time of the first gastrointestinal bleeding appearance was 26 ± 24.4 weeks.