Adjunctive Drug Therapy for Diabetes Pharmacologic measures to prevent or treat complications of diabetes mellitus (1 - 3) are critical, including Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) Aspirin Statins ACE inhibitors or ARBs are indicated for patients with evidence of early diabetic nephropathy (albuminuria), even in the absence of hypertension, and are a good choice for treating hypertension in patients who have diabetes mellitus and who have not yet shown renal impairment.