Result: Prevalence of sepsis in 1000 in-patients treated in 108 Military Central Hospital from 2015 to 2018 was increased (2.14/1000 patients to 4.27/1000 patients); Septic shock was also significant increased (44.2% to 52.7%); mortality rate was still high (48.4%); almost sepsis patients were older than 50 years old and have had chronic diseases such as hypertension, diabetes mellitus, Gout and cancer... One important result is that the hospital acquired sepsis was significant reducing (50.6% to 26.2%).