Review of systems should seek symptoms of possible causes, including Runny, congested nose (URI) Sore throat (pharyngitis, mononucleosis) Mouth, gum, or tooth pain (oral-dental infection) Cough and / or dyspnea (sarcoidosis, lung cancer, TB, some fungal infections) Fever, fatigue, and malaise (mononucleosis and many other infections, cancers, and connective tissue disorders) Genital lesions or discharge (herpes simplex, chlamydia, syphilis) Joint pain and / or swelling (systemic lupus erythematosus [SLE] or other connective tissue disorders) Easy bleeding and / or bruising (leukemia) Dry, irritated eyes (Sjögren syndrome) Past medical history should identify risk factors for (or known) TB or HIV infection, and cancer (particularly use of alcohol and / or tobacco).