To evaluate the results of surgical treatment of descending necrotizing mediastinitis (DNM) at Viet Duc Hospital. Subject and method: A prospective and retrospective study of cases diagnosed DNM due to perforation of the esophagus were treated in Viet Duc Hospital from 1/2016 to 3/2019 including the deaths and discharged to die. The diagnosis criterias of DNM was based on Estrera (1983) standard.