The next most common manifestations, in decreasing order of frequency, are inflammation of the Eye (eg, conjunctivitis, scleritis, iritis, keratitis, chorioretinitis) Cartilaginous tissue of the larynx, trachea, or bronchi (causing hoarseness, cough, and tenderness over the laryngeal cartilage) Internal ear Cardiovascular system (eg, aortic regurgitation, mitral regurgitation, pericarditis, myocarditis, aortic aneurysms, aortitis) Kidney Skin Bouts of acute inflammation heal over weeks to months, with recurrences over several years.