When warmth, redness, and swelling involve multiple joints, evaluation for a systemic cause of joint inflammation (eg, gout, RA, psoriatic arthritis, viral-associated arthritis, enteropathic arthritis) with a rheumatic disease assessment (eg, anticyclic citrullinated peptide [anti-CCP] antibody, rheumatoid factor [RF], erythrocyte sedimentation rate) is indicated.