- Olanzapine is a neuroleptic associated with a high level of metabolic syndrome, after 12 weeks of treatment in patients with paranoid schizophrenia with weight gain of 5.65 kg, an increase in BMI of 2, 24 kg / m2, waist circumference increased to 7.28 cm, weight gain rate ≥7% after 12 weeks was 73.1%.