Treatment of Behçet Disease Colchicine, dapsone, azathioprine, apremilast, thalidomide, anti-tumor necrosis factor (TNF) drugs, and / or interferon for mucosal disease Azathioprine, methotrexate, cyclosporine, or anti-TNF drugs for eye disease Anti-TNF drugs, cyclophosphamide, and chlorambucil for refractory, severe central nervous system, or life-threatening disease Treatment of Behçet disease depends on the clinical manifestations.