Carpal Tunnel Syndrome By David R Steinberg, MD, Perelman School of Medicine at the University of Pennsylvania Reviewed / Revised Apr 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Carpal Tunnel Carpal Tunnel Syndrome Neutral wrist splint Carpal tunnel syndrome is compression of the median nerve as it passes through the carpal tunnel in the wrist.