Brain Herniation By Kenneth Maiese, MD, Rutgers University Reviewed / Revised May 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Brain herniation Subfalcine Herniation Effects of Brain Herniation Brain herniation occurs when increased intracranial pressure causes the abnormal protrusion of brain tissue through openings in rigid intracranial barriers (eg, tentorial notch).