Results: Levels of serum TGF-beta1; in patients <40 year old, 40 - 60 year old and > 60 year of age were respectively 39, 97 ± 9, 76 ng / ml; 36, 07 ± 10, 10 ng / ml and 38, 29 ± 10, 87 ng / ml, p> 0, 05.