After six months being treated with timolol maleate 0.5% ophthalmic solution, the ratio of lesions which had complete improvement was 21.4% (3/14), substantial change in 28.7% (4/14), moderate change in 21.4% (3/14), fair change in 14.3% (2/14), and 7.1% (1/14) remains in which their lesions had the minimal change, only one (7.1% - 1/14) case did not change and the lesion was to be increasing in size.