Ultrasound Obstet Gynecol 51 (5): 586 - 595, 2018. doi: 10.1002 / uog.18961 Treatment of Endometriosis Nonsteroidal anti-inflammatory drugs (NSAIDs) for discomfort Estrogen-progestin contraceptives Drugs to suppress ovarian function Conservative surgical resection or ablation of endometriotic tissue, with or without drugs Total abdominal hysterectomy with or without bilateral salpingo-oophorectomy if disease is severe and the patient has completed childbearing Symptomatic medical treatment begins with analgesics (usually NSAIDs) and hormonal contraceptives.