Nephronophthisis and Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) By Enrica Fung, MD, MPH, Loma Linda University School of Medicine Reviewed / Revised Apr 2023 View Patient Education Nephronophthisis Diagnosis Treatment Autosomal dominant tubulointerstitial kidney disease (ADTKD) Key Points Topic Resources Autosomal Dominant Tubulointersti... Nephronophthisis and autosomal dominant tubulointerstitial kidney disease (ADTKD) are inherited disorders that cause cysts restricted to the renal medulla or corticomedullary border and, eventually, end-stage kidney disease (ESKD).