Biological investigations in IDU with and without TB infected with HTLV1 show that there is no statisticaly difference concerning the 3 lines of peripheral blood cells in the HTLV (-) compared with HTLV1 (+) (p>0.05) but the decrease of T CD4 (<300 / mm3) is statisticaly difference (p<0.05) in IDU / HIV (+) / HTLV (+) having TB.