Treatment of Blepharitis Antimicrobials for acute ulcerative blepharitis; warm compresses and sometimes topical corticosteroids for acute nonulcerative blepharitis For chronic blepharitis, treatment of keratoconjunctivitis sicca, warm compresses, cleansing of eyelids, and sometimes topical or systemic antibiotics as clinically indicated Acute blepharitis Acute ulcerative blepharitis is treated with an antibiotic ointment (eg, bacitracin / polymyxin B, erythromycin, or gentamicin 0.3% 4 times a day for 7 to 10 days).