Bleeding is generally considered severe when it is: Heavy (loss of ≥ 2 units of blood in ≤ 7 days) In a critical location (eg, intracranial, intraocular) In a location where hemostasis is difficult to achieve (eg, small bowel, posterior nasal cavity, lung) Risk factors for severe bleeding include Age ≥ 65 History of prior gastrointestinal bleeding or stroke Recent myocardial infarction Coexisting anemia (hematocrit < 30%), renal insufficiency (serum creatinine > 1.5 mg / dL [115 micromol / L]), or diabetes Supportive care for severe bleeding includes local measures to stop bleeding (eg, direct pressure, cauterization, injection).