Myelophthisic Anemia By Gloria F Gerber, MD, Johns Hopkins School of Medicine, Division of Hematology Reviewed / Revised Jun 2023 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Key Points Myelophthisic anemia is a normocytic, normochromic anemia that occurs when normal marrow space is infiltrated and replaced by nonhematopoietic or abnormal cells.