Objectives: to describe some symptoms of depressive disorder, to determine the prevalence of depression in chronic hepatitis C patients before receiving specific procedures as well as to evaluate the relationship between depression and related factors. Method: a cross-sectional study was conducted to examine 397 chronic hepatitis C patients by the Hamilton rating scale for depression 17 (HAMD-17) in the Out-patient Department of the Tropical Disease Hospital from December 1st, 2008 to March 30th, 2009.Results: a high percentage of the patients had positive scores of depression (34.3%) and majority of them had mild (64%) and average depression (29.4%).