Corresponding to that sufficient PSI, the average TCI propofol concentration is: Cp = 1.98mcg / ml (with 95% confidence interval: 1.87 - 2.09); Ce = 1.25mcg / ml (with 95% confidence intervals: 1.22 - 1.29) - Sedation should be carried out on a low to high titration method to achieve the earliest sedation and reduce the number of titrations.