The mean TBUT also increased from 4.1 ± 1.3 at baseline to 9.3 ± 1.2 after 2 month follow-up (p < 0.001) and 10.4 ± 1.4 after 4 month follow-up (p < 0.001) As compared the effectiveness of these two drugs, there were not statistically difference found with the mean OSDI and Schirmer test (p = 0.09 and p = 0.21).