Treatment of Heart Disorders in Pregnancy Avoidance of warfarin, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), aldosterone antagonists, thiazide diuretics, and certain antiarrhythmics (eg, amiodarone) For NYHA class III or IV, activity restriction and possibly bed rest after 20 weeks Most other usual treatments for heart failure and arrhythmias Frequent prenatal visits, ample rest, avoidance of excessive weight gain and stress, and treatment of anemia are required.