Down-regulation of ACE2 as a result of SARS-CoV-2 entry process and viral replication into alveolar epithelial cells reflects a pivotal role in the pathogenesis of COVID-19 (Vaduganathan et al, 2020), since ACE2 acts converting angiotensin II (AngII) into angiotensin 1 - 7 (Ang1 - 7), thus exerting beneficial effects on lung injury and vascular damage in converting unabated angiotensin II (AngII) to angiotensin 1 - 7 (Ang1 - 7), which exert beneficial effects against lung injury and vascular lesion (Vaduganathan et al, 2020).