Result: The most common acute peripheral neurourly was numbness of extremities when experiencing cold (64.4% in XELOX regimen and 65.4% in mFOLFOX6 regimen), numbness at the infusion site was more common in XELOX regimen (38.4% vs 15.4%; p=0.001); jaw pain was more common in XELOX regimen (20.5% vs 3.8%; p=0.002).