3.2.4 Characteristics related to the dose of anesthetic used First dose volumes of the two groups Table 3.12: Characteristics of the first dose of the two groups Group Characteristics Group B (n = 52) Group R (n = 52) p First dose volume (ml) 5.92 ± 0.71 5.9 ± 0, 92 > 0.05 Min-Max 4.8 - 7.5 4 - 8 First dose onset t ime (minutes) 10.8 ± 1.9 13.0 ± 1.6 < 0.05 Min-Max 8 - 16 10 - 16 T ime of patient pressing first required dose (hours) 8.6 ± 1.5 7.1 ± 1.65 < 0.05 Min-Max 5 - 13 4 - 13 Comment: The first dose volume of the lowest two groups was 4 ml and the highest was 8 ml, the difference was not statistically significant with p> 0.05.