Overview of Vascular Bleeding Disorders By David J Kuter, MD, DPhil, Harvard Medical School Reviewed / Revised May 2023 View Patient Education Bleeding may result from abnormalities in Platelets Coagulation factors Blood vessels Vascular bleeding disorders result from defects in blood vessels, typically causing cutaneous or mucosal lesions called petechiae, purpura, and ecchymoses depending on their size but, except for hereditary hemorrhagic telangiectasia, seldom leading to serious blood loss.