Group B before treatment, dic+r: 4.75 ± 0.82%, fr+mi: 6.3 ± 1.05, after treatment 3th days, dic + r: 6.50 ± 0.66%, fr+mi: 9.40 ± 1.40%, after 7th days dic+r: 5.73 ± 0.71, fr+mi: 7.11 ± 0.98, after 3th month: dic+r: 5.37 ± 0.85, fr+mi: 6.75 ± 1.49 and after 6th months, dic +r: 5.06 ± 1.57%, fr+mi: 5.89 ± 2.0%.