At before treatment, and followed up at 3 months, means of tear break up time score were 6.01 ± 4.58 and 8.45 ± 4.43 seconds (p < 0.05 Mann-Whitney U) respectively in diquafosol 3% group, 6.12 ± 4.28 and 7.47 ± 4.91 seconds (p < 0.05) respectively in sodium hyaluronate 0.1% group.