Empiric regimens include use of one or two of the following: Amoxicillin / clavulanic acid 500 mg 3 times a day Cephalexin 250 mg 4 times a day Trimethoprim / sulfamethoxazole 160/800 mg 2 times a day Metronidazole 250 to 500 mg 3 or 4 times a day Rifaximin 550 mg 3 times a day alone or in combination with neomycin 500 mg 2 times a day (usually the combination is used if the methane breath test is positive) Ciprofloxacin 500 mg 2 times a day Antibiotic treatment can be cyclic, if symptoms tend to recur, and changed based on culture and sensitivity.