Cholesteryl Ester Storage Disease and Wolman Disease (Wolman's Disease) By Matt Demczko, MD, Mitochondrial Medicine, Children's Hospital of Philadelphia Reviewed / Revised Oct 2021 | Modified Sep 2022 View Patient Education More Information Cholesteryl ester storage disease and Wolman disease are sphingolipidoses, an inherited disorder of metabolism, caused by lysosomal acid lipase deficiency resulting in hyperlipidemia and hepatomegaly.