Methods: The first period, accidental and controlled clinical trial, 63 chronic hepatitis B patients who were treated by Tenofovir in 12 months, HBV DNA - negative, HBeAg - positive. They were assigned into 2 groups: Group 1 was used product Phyllanthus urinaria and Tenofovir, group 2 was used pure Tenofovir for 6 months.