Clindamycin is part of combination therapy for the following: With penicillin for infections caused by toxigenic streptococci (because clindamycin decreases the bacteria's toxin production) With pyrimethamine for cerebral toxoplasmosis With quinine for babesiosis or falciparum malaria With primaquine for Pneumocystis jirovecii pneumonia Clindamycin can be used for infections (eg, skin and soft-tissue infections) in communities where community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is common; whether clindamycin is useful depends on local resistance patterns.