Medications associated with GI bleeding include anticoagulants (eg, heparin, warfarin, dabigatran, apixaban, rivaroxaban, edoxaban), those affecting platelet function (eg, aspirin and certain other nonsteroidal anti-inflammatory drugs [NSAIDs], clopidogrel, selective serotonin reuptake inhibitors [SSRIs]), and those affecting mucosal defenses (eg, NSAIDs).