Congenital and Perinatal Cytomegalovirus Infection (CMV) By Brenda L Tesini, MD, University of Rochester School of Medicine and Dentistry Reviewed / Revised Jul 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Prognosis Treatment Prevention Key Points Topic Resources Congenital Cytomegalovirus... Cytomegalovirus infection may be acquired prenatally or perinatally and is the most common congenital viral infection.