In contrast, US Food and Drug Administration-approved nicotine replacement therapies have demonstrated effectiveness in helping smokers quit with several additional benefits: Few and mild side-effects Low likelihood of inducing dependence No potential for abuse among youth or evidence that youth will transition to using combustible tobacco products If patients have been unsuccessful with evidence-based approaches to quitting smoking in the recent past and are intent on trying e-cigarettes, clinicians ought to provide support and encourage their efforts with a focus on switching completely from combustible to electronic cigarettes.