Respiratory problems in neonates include Apnea of prematurity Bronchopulmonary dysplasia Meconium aspiration syndrome Persistent pulmonary hypertension Pulmonary air-leak syndromes Respiratory distress syndrome Transient tachypnea Symptoms and signs of respiratory distress vary and include the following: Grunting Nasal flaring Intercostal, subcostal, and suprasternal retractions Weak breathing, irregular breathing, or a combination Tachypnea and apneic spells Cyanosis, pallor, mottling, delayed capillary refill, or a combination Hypotension In neonates, symptoms and signs may be apparent immediately on delivery or develop minutes or hours afterward.