Corticosteroids, fludarabine, rituximab, proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide, lenalidomide, and pomalidomide), Bruton's tyrosine kinase inhibitors (ibrutinib, acalabrutinib, and zanubrutinib), idelalisib, everolimus, or the combination of ibrutinib and rituximab may be helpful; other alkylating drugs can be used for palliation.