Objective: Observation of clinical features, laboratory and treatment, and evaluation of the effectiveness of Artesunate monotherapy in the treatment of severe and complicated malaria due to Plasmodium falciparum in the intensive care department of Phu Yen Hospital, 2012. Subjects and Methods: Retrospective, descriptive cross-sectional study of all patients with confirmed diagnosis of severe and complicated malaria from 1 - 1 - 2012 to 30 - 10-1012.