Contraindications and Precautions of Pneumococcal Vaccine The main contraindication for PCV13 is A severe allergic reaction (eg, anaphylaxis) after a previous dose of PCV7 or PCV13, to a vaccine component, or to any vaccine containing diphtheria toxoid The main contraindication for PCV15 is A severe allergic reaction (eg, anaphylaxis) to any component of PCV15 or to diphtheria toxoid The main contraindication for PCV20 is A severe allergic reaction (eg, anaphylaxis) to any component of PCV20 or to diphtheria toxoid The main contraindication for PPSV23 is A severe allergic reaction after a previous dose of the vaccine or to a vaccine component Precautions with either type of vaccine include Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves) For children with functional or anatomic asplenia, meningococcal conjugate vaccine (MenACWY) and PCV13 should not be given during the same visit but should be separated by ≥ 4 weeks.