Results: 200 chronic HBV infected patients were included, 64% were males, 60% HBeAg positive, 56% HBV genotype C The most common point mutations in PreS gen were: K57Q / K (25.8%), E / D54A / N (26.8%), A60V (26.3%), D62S (25.8%), T125S / N / P (30.6%).