Red flags The following findings are of particular concern: Acute episode with dyspnea, diaphoresis, or tachycardia Anorexia Nausea or vomiting Weight loss Blood in the stool Dysphagia or odynophagia Failure to respond to therapy with H2 blockers or proton pump inhibitors (PPIs) Interpretation of findings Some findings are helpful (see Table: Some Causes of Dyspepsia).