Treatment of Nephrotic Syndrome Treatment of causative disorder Angiotensin inhibition Sodium restriction Statins Diuretics for excessive fluid overload Rarely, nephrectomy Treatment of disorder causing nephrotic syndrome Treatment of underlying disorders may include prompt treatment of infections (eg, staphylococcal endocarditis, malaria, syphilis, schistosomiasis), and stopping medications (eg, gold, penicillamine, nonsteroidal anti-inflammatory drugs [NSAIDs]); these measures may cure nephrotic syndrome in specific instances.