Mild: Pain restricted to the bite site, normal vital signs Moderate: Diaphoresis and piloerection in the area of the bite, cramping pain in large muscle groups of the trunk, normal vital signs Severe (also called latrodectism): Diaphoresis at a remote site; intense generalized cramping pain in large muscle groups of the trunk; hypertension and tachycardia; often headache, nausea, and vomiting Latrodectism, a systemic syndrome caused by neurotoxic venom components of widow spider bites, manifests as restlessness, anxiety, sweating, headache, dizziness, nausea, vomiting, hypertension, salivation, weakness, diffuse erythematous rash, pruritus, ptosis, eyelid and extremity edema, respiratory distress, increased skin temperature over the affected area, and cramping pain and muscular rigidity in the abdomen, shoulders, chest, and back.