The IPSS-R considers the following risk factors: Cytogenetics: Worst prognosis associated with high-risk or multiple abnormalities Percentage of bone marrow blasts: Worst prognosis associated with increasing numbers of (particularly >10%) blasts Degree of cytopenia: Worst prognosis associated with hemoglobin < 8 g / dL (< 80 g / L), platelet count < 50, 000 / mcL (< 50 × 10 9 / L) and absolute neutrophil count (ANC) < 800 / mcL (0.8 × 10 9 / L) Outcome is worse with an increasing number of risk factors.