Fluoroquinolones are divided into 2 groups, based on antimicrobial spectrum and pharmacology: Older group: Ciprofloxacin, norfloxacin, and ofloxacin Newer group: Delafloxacin, gemifloxacin, levofloxacin, and moxifloxacin Many newer fluoroquinolones have been withdrawn from the US market because of toxicity when given systemically; they include trovafloxacin (because of severe hepatic toxicity), gatifloxacin (because of hypoglycemia and hyperglycemia; it is still available in the US as an ophthalmic preparation), grepafloxacin (because of cardiac toxicity), temafloxacin (because of acute renal failure, hepatotoxicity, hemolytic anemia, coagulopathy, and hypoglycemia), and lomefloxacin, sparfloxacin, and enoxacin.