With the dose of 4.32 g / kg / day ACNECA had anti-inflammatory effect on mice edema model with the level of inhibiting inflammation in acute and sub-acute inflammation was 46.74% and 14.17% (p <0.05). ACNECA dose of 1.44 g / kg / day was only effectiveness on acute inflammatory model with the level of inhibiting inflammatory of 43.24% (p <0.05).