Treatment of Erysipeloid Penicillin, cephalosporins, fluoroquinolones, or clindamycin For localized cutaneous disease, usual treatment is one of the following, given for 7 days: Penicillin V or ampicillin (500 mg orally every 6 hours) Ciprofloxacin (250 mg orally every 12 hours) Clindamycin (300 mg orally every 8 hours) Cephalosporins are also effective.