Treatment of ALL Systemic chemotherapy Prophylactic CNS chemotherapy and sometimes CNS radiation For Ph+ ALL, also a tyrosine kinase inhibitor Supportive care Sometimes immunotherapy, targeted therapy, stem cell transplantation, and / or radiation therapy Treatment for newly diagnosed acute lymphoblastic leukemia generally consists of 3 to 4 cycles of chemotherapy blocks of non-cross-resistant chemotherapy for the first 9 to 12 months, followed by 2.5 to 3 years of maintenance chemotherapy.