Peutz-Jeghers Syndrome (Peutz-Jegher's Syndrome) By Minhhuyen Nguyen, MD, Fox Chase Cancer Center, Temple University Reviewed / Revised Mar 2021 | Modified Sep 2022 View Patient Education More Information Topic Resources Peutz-Jeghers Syndrome (Perioral... Peutz-Jeghers Syndrome (Hand... Peutz-Jeghers syndrome is an autosomal dominant disease with multiple hamartomatous polyps in the stomach, small bowel, and colon along with distinctive pigmented skin lesions.