Percentage of severe hematological adversed effects is: reduced hemoglobin below 70 g / l - 4.2%; reduced neutrophil count below 1 x 109 / l - 8.3%; reduced platelet count below 50 x 109 / l - 9.5%; (2) Characteristics and percentage of non-hematological adversed effects: Most common adversed effects are periorbital oedema - 28.6%); bone pain - 20.2%; vomiting and nausea - 16.1%.