Treatment of H pylori Infection Antibiotics (various regimens) plus a proton pump inhibitor For confirmation of cure, urea breath test, stool antigen assay, or upper endoscopy (See also the American College of Gastroenterology's [ACG] 2017 guidelines Treatment of Helicobacter pylori Infection and the European 2022 guidelines Management of Helicobacter pylori infection: The Maastricht VI / Florence consensus report.)