Treatment of Calcium Pyrophosphate Arthritis Intra-articular corticosteroids Oral corticosteroids (eg, prednisone, methylprednisolone) Nonsteroidal anti-inflammatory drugs (NSAIDs) Colchicine Interleukin-1 (IL-1) antagonists (eg, anakinra) Treatment of acute CPP arthritis is similar to that for acute gout.