Risk factors for severe disease The risk of serious disease and death in COVID-19 cases increases in people over age 65, in people who smoke or previously smoked, and in people with other serious medical disorders, such as Cancer Chronic heart, lung, kidney, or liver disease Diabetes Stroke or cerebrovascular disease Immunocompromising conditions HIV infection Tuberculosis Sickle cell disease Thalassemia Dementia Obesity Pregnancy (up to 42 days after pregnancy) Some types of disabilities Substance use disorders Physical inactivity Some mental health disorders such as depression and schizophrenia (Also see CDC: COVID-19 Information for Specific Groups of People.)