Opioid Use Disorder and Rehabilitation By Gerald F O'Malley, DO, Grand Strand Regional Medical Center; Rika O'Malley, MD, Grand Strand Medical Center Reviewed / Revised Dec 2022 View Patient Education Treatment More Information Topic Resources QT Interval Correction (EKG) "Opioid" is a term for a number of natural substances (originally derived from the opium poppy) and their semisynthetic and synthetic analogs that bind to specific opioid receptors.