Lancet Respir Med 9 (12): 1387 - 1395, 2021. doi: 10.1016/S2213 - 2600 (21) 00356 - 8 Sedation and comfort Although many patients tolerate mechanical ventilation via endotracheal tube without sedatives, some require IV administration of sedatives (eg, propofol, lorazepam, midazolam) and analgesics (eg, morphine, fentanyl) to minimize stress and anxiety.