The dose is 75 / mg / m2 / day for 42 days (including weekend days when radiation is skipped) Then 150 mg / m2 orally once a day for 5 days a month during the next month Followed by 200 mg / m2 orally once a day for 5 days a month in subsequent months for a total of 6 to 12 months During treatment with temozolomide, trimethoprim / sulfamethoxazole 800 mg/160 mg is given 3 times a week to prevent Pneumocystis jirovecii pneumonia.