PSI index and concentration of Ce, Cp propofol and 95% confidence in overall clinical titrations to achieve an OAA / S sedation of 3 points Group I N = 144 times/50 patients SDX Min - Max Group II N = 182 times/49 patients SDX Min - Max p Cp (mcg / ml) 1, 99±0, 66 1, 00 - 3, 84 1, 48±1, 48 0, 50 - 7, 51 < 0, 01 Ce (mcg / ml) 1, 25±0, 21 0, 91 - 1, 84 1, 69±0, 30 1, 00 - 2, 91 < 0, 01 PSI 75, 28±3, 08 61 - 82 74, 34±3, 27 64 - 89 < 0, 01 The number of times of conducting the average titration in Group I is 144: 50 = 2.88 times and in Group II, 182: 49 = 3.71 times.