For drug therapy in adults, the AHA / ACC Guidelines recommend treatment with a statin for 4 groups of patients, comprised of those with any of the following: Clinical ASCVD LDL-C ≥ 190 mg / dL (≥ 4.9 mmol / L) Age 40 to 75 years, with diabetes and LDL-C 70 to 189 mg / dL (1.8 to 4.9 mmol / L) Age 40 to 75 years, with LDL-C 70 to 189 mg / dL (1.8 to 4.9 mmol / L), and an estimated 10-year risk of ASCVD ≥ 7.5% Risk of ASCVD is estimated using the pooled cohort risk assessment equations.