Risk factors for coccidioidomycosis Progressive coccidioidomycosis is uncommon in otherwise healthy people and more likely to occur in the following contexts: HIV infection Use of immunosuppressants Advanced age 2nd half of pregnancy or postpartum Certain ethnic backgrounds (Filipino, African American, Native American, Hispanic, and Asian, in decreasing order of relative risk) Symptoms and Signs of Coccidioidomycosis Primary coccidioidomycosis Most patients with primary coccidioidomycosis are asymptomatic, but nonspecific respiratory symptoms resembling those of influenza, acute bronchitis, or, less often, acute pneumonia or pleural effusion sometimes occur.