Symptoms of hepatotoxicity (jaundice, elevated transaminases, elevated bilirubin) occurred more frequently in patients who were seropositive for viral hepatitis B and / or C (Ags HBs + and / or HCV Antibodies +) compared to patients with negative tests: 40% of those who are seropositive for hepatitis B or C or both met criteria for ADR and 18.9% of seronegative patients met your criteria for ADR.