Neonates of mothers with untreated gonorrhea should receive a single injection of ceftriaxone 25 to 50 mg / kg IM or IV, up to 125 mg (ceftriaxone should not be used in neonates with hyperbilirubinemia or those receiving calcium-containing fluids), and both mother and neonate should be screened for chlamydia infection, HIV, and syphilis.