Anaphylactic signals were detected including iopamidol (ROR = 2.61 [1.05 - 6.51] in 2015), iohexol (ROR = 2.21 [1.30 - 3.75] in 2016), and iobitridol (ROR = 1.39 [1.04 - 1.85] in 2018, ROR = 1.43 [1.13 - 1.80] in 2019).