After that, histological examination and immunohistochemical staining were performed to assess the expression of p53 (using Ventana's Monoclonal Mouse Anti-human p53 protein Clone DO - 7 antibody) Results: In 94 cases surveyed, there were 14 cases of carcinoma on the background of high-grade dysplasia adenoma with p53 expression, 8 cases of complete loss of expression, 5 cases of p53 overexpression and 1 case of moderate expression. jar.