+ The rate of regional lymph node metastasis is higher in the group of patients with some of the following factors: disease duration > 6 months, tumor location in the soles of the feet, tumor background is keratinized skin and normal skin, ulcerative warts. skin and skin ulcers, histopathology is apical and localized mole, microscopic tumor thickness > 4 mm, Clark IV-V invasion, vertical growth stage, satellite nucleus Peritumours, tumors with vascular infiltration, non-tumor-infiltrating lymphocytes, tumors with a ratio of >6 nuclei / mm2, and tumors with microscopic ulcers.