Diagnosis of Ehlers-Danlos Syndromes Clinical criteria Confirmatory genetic testing Echocardiography and / or other vascular imaging to screen for cardiovascular complications Most but not all types of Ehlers-Danlos syndrome involve one or both of the following: Joint hypermobility Skin hyperextensibility Thus, diagnosis of Ehlers-Danlos syndromes may be suspected in patients who present with complaints such as frequent joint dislocations, poor wound healing, and / or frequent or unusual scarring.