Antibiotics can be grouped into 3 general categories (1) based on the pharmacokinetics that optimizes antimicrobial activity (pharmacodynamics): Concentration-dependent: The magnitude by which the peak concentration exceeds the MIC (typically expressed as the peak-to-MIC ratio) best correlates with antimicrobial activity Time-dependent: The duration of the dosing interval in which the antibiotic concentration exceeds the MIC (typically expressed as the percentage of time above MIC) best correlates with antimicrobial activity Exposure-dependent: The amount of drug given relative to the MIC (the amount of drug is the 24-hour area under the concentration-time curve [AUC24]; the AUC24-to-MIC ratio best correlates with antimicrobial activity) Aminoglycosides, fluoroquinolones, and daptomycin exhibit concentration-dependent bactericidal activity.