Focal hypopigmentation is most commonly a consequence of Injury Inflammatory dermatoses (eg, atopic dermatitis, psoriasis) Burns Chemical exposure (especially to hydroquinones and phenols) Focal hypopigmentation or depigmentation is also a feature of vitiligo (which may involve large areas of skin), leprosy, nutritional deficiencies (kwashiorkor), genetic conditions (eg, tuberous sclerosis, piebaldism, Waardenburg syndrome), morphea (localized scleroderma, in which skin is usually sclerotic), lichen sclerosus, pityriasis versicolor (or tinea versicolor), idiopathic guttate hypomelanosis, progressive macular hypomelanosis, postinflammatory hypopigmentation, and pityriasis alba.