Objective: Compare postoperative pain after laparoscopic versus open colorectal cancer surgery at C department. Materials and methods: A prospective controlled study was carried out on 40 patients with colorectal cancer who were divided into 2 groups: laparoscopic and open surgeries from 3/2010 to 7/2010 in age, sex, surgical methods and postoperative pain levels. Results: Postoperative pain of patients in laparoscopic group was less than that of those in open group on 2nd, 3rd, 4th postoperative days.