On these premises, VitD supplementation could be potentially useful in states of vitD deficiency, despite the administration route, such as intramuscular, may be questionable as it may change the physiologic effects of VitD (Zheng et al, 2015); As stressed by some randomized controlled trials (RCTs) and observational studies, Highdose VitD is associated with increased incidence of pathological fractures in elderly (Sanders et al, 2012), which might be as a consequence of cerebellar neurons involvement due to high density VitD receptors and central nervous toxicity (Harms et al, 2011) and also that high-level of VitD causes 24‐hydroxylase over activation which leads to VitD resistance which in turn can cause higher cancer incidence as well (Tuohimaa et al, 2004).