Ehlers-Danlos Syndromes By Frank Pessler, MD, PhD, Helmholtz Centre for Infection Research Reviewed / Revised Dec 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Key Points More Information Topic Resources Ehlers-Danlos Syndrome Ehlers-Danlos syndromes are hereditary collagen disorders characterized by joint hypermobility, dermal hyperelasticity, and widespread tissue fragility.