Primary Malignant Bone Tumors By Michael J Joyce, MD, Cleveland Clinic Lerner School of Medicine at Case Western Reserve University; David M Joyce, MD, Moffitt Cancer Center Reviewed / Revised Jul 2022 | Modified Sep 2022 View Patient Education Topic Resources Multiple Myeloma Osteosarcoma Adamantinoma Chondrosarcoma of the Humerus Chordoma Ewing Sarcoma of the Radius Ewing Sarcoma of Bone Lymphoma of Bone Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults.