Lipid disorders can lead to symptomatic end-organ disease, including Vascular disease (eg, coronary artery disease (CAD), stroke, and peripheral arterial disease) Acute pancreatitis can be caused be high TG levels (> 500 mg / dL [> 5.65 mmol / L]) Hepatosplenomegaly can be caused by very high TG levels Findings in patients with severe dyslipidemia may include localized lipid deposits (xanthomas) or other findings caused by high serum concentrations or accumulation of lipids.