Treatment of Ulcerative Colitis Dietary management and loperamide (except in acute severe attacks) for symptom relief 5-Aminosalicylic acid (5-ASA) Corticosteroids and other drugs depending on symptoms and severity Antimetabolites, biologic agents, a Janus kinase inhibitor, or sphingosine 1-phosphate (S1P) receptor modulator Sometimes surgery Details of specific drugs and dosages are discussed in Drugs for Inflammatory Bowel Disease.