Objectives: Determine the rate and type of EGFR mutations and the expression of P53 markers and Ki67 in patients with squamous cell carcinoma of the sinonasal. The study subjects included 48 cases of squamous cell carcinoma with histopathological diagnosis, EGFR mutation test results on Colbas 4800 and immunohistochemical staining results of P53 and Ki67 markers on the machineVenatana automatic dyeing.