Result: Through 107 patients with hepatocellular carcinoma undergoing hepatectomy, in which 55 patients with open hepatectomy and 52 patients with laparoscopic hepatectomy, the comparison results between the two groups showed that: Major liver resection in the open surgery group accounted for a higher rate (41.8% vs 30.8%), shorter operation time in the open surgery group (167.6 ± 37.8 minutes and 194.5 ± 66.2 minutes), blood loss intraoperative and blood transfusion rates were not different (264.9 ± 280.1ml vs 248.7 ± 171.6ml; 7.3% vs 3.8%); The rate of bile leak (5.4% vs 3.8%) and pleural effusion (3.6% vs 3.8%) between the two groups were not statistically significant with p=0.435 and 0, 91; The mean post-operative hospital stay in the two groups was 9.6 ± 4.8 and 8.8 ± 3.8 days.