IV propofol: Titrate doses to patient response (deep sedation), as follows: Initial dose: 0.5 to 1.0 mg / kg IV (1.0 to 2.0 mg / kg for children) Subsequent doses (after 1 to 3 minutes): 0.25 to 0.5 mg / kg IV every 1 to 3 minutes For obese and older patients, start with lower doses.