The subjects were divided into two groups: 1) subjects picked from 1 November 2016 until 15 March 2017 were treated immediately with triple therapy OAM or EAM (without antibiograms); 2) subjects picked from 16 March 2017 until 30 August 2017 were treated with a PPI for three weeks and wait for the result of antibiograms to get medication for treatment in the next two weeks (with antibiograms and PCR gene CYP2C19).