Fourty patients, aged range 30 - 63 years old who were anesthetized in colorectalectomy laparoscopic surgery, all of which were induced by propofol, rocuronium, fentanyl and maintain anesthesia with sevoflurane and randomized into two groups: 20 patients in the Entropy group was adjusted anesthesia by Gruman scheme (group E), 20 patients in the control group was adjusted anesthesia based on the clinical signs (group C).