Drug treatment Three classes of drugs have been used in infants with GERD who do not respond to feeding modification and positioning: Proton pump inhibitors (PPI) Histamine-2 (H2) blockers Promotility drugs A 2018 consensus practice guideline from North American and European specialty societies recommends that infants and children with GERD unresponsive to feeding and positioning modifications be given a proton pump inhibitor (PPI).