The results show that negative pressure wound therapy improves infection representing by reduction of culture results (+) and WBC reduction, wound healing processes are progressing; epidermal growth factor helps accelerate the process of wound healing on diabetic foot ulcers, a rate of epithelialization from 4.2 ± 1.7 mm after 1 week of treatment, and the wounds are healing well after 41.6 ± 13.6 days.