The main effects of IL-5 are Induction of eosinophil and activated B-cell proliferation Induction of switch to IgA Clinical relevance of IL-5 includes For anti-IL-5 mAb, treatment of patients with severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis For anti-IL-5 receptor mAb, treatment of patients with severe eosinophilic asthma IL-6 is produced by dendritic cells, fibroblasts, macrophages, monocytes, and Th2 cells.