Neonatal Herpes Simplex Virus (HSV) Infection By Brenda L Tesini, MD, University of Rochester School of Medicine and Dentistry Reviewed / Revised Jul 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Prognosis Treatment Prevention Key Points Topic Resources Localized Herpes Simplex... Disseminated Herpes Simplex... Neonatal Herpes Simplex Virus... Neonatal herpes simplex virus infection is usually transmitted during delivery.