Purpose: To evaluate the efficacy, safety of endoscopic septoplasty technique in relieve headache due to septal air cell at the spheno-ethmoidal recess. Method: In a prospective new technique application study on 17 patients undergoing surgery for relieve headache due to septal air cell at the sphenoid - ethmoidal recess which were divided into two group: group A: 11 cases received endoscopic septoplasty with sphenoidotomy and Group B: 6 cases received only septoplasty. Result: After mean follow-up time of 6.2 months.