Among the adhesives containing - OH functional group, DT - 2510 showed a higher skin permeation rate of scopolamine with the most target flux of scopolamine for rat skin was 32.88µg / cm2 / hour with the most suitable lag time (2.72 hours). Conclusion: The study of effect of different acrylic adhesive polymer on the permeation of scopolamine hydrobromide through excised rat skins resulted in gradually decreasing levels: the adhesives of - OH functional group, none functional group, - COOH functional group respectively.