Subjects and methods: Prospective, interventional, vertical following-up study with a control group, 101 patients with 151 osteoarthritis knees in grade II, III according to Kellgren and Lawrence, divided into two groups: the intervention group was intra-articular injected a single Synolis VA 80/160mg into knee osteothritis, the control group was treated with oral medicine Mobic, Viatril S Result: VAS pain score, WOMAC index, and knee range of motion of intervention group have significantly improved starting from the 4-week and continuing until the 12-week, statistically better than the control group (p<0, 01).