Different ethnic groups have showed different patterns of genetic polymorphisms; this finding requires studying a pattern of genetic polymorphism in a specific population. Aims: Studying characteristics and prevalence of IL-1RN polymorphisms in Vietnamese; doing comparison between Vietnamese and the two groups: East-Asia and Western countries in this gene; examining the correlation between IL-1RN polymorphisms and Helicobacter pylori infection in Vietnamese. Methods: 130 healthy Vietnamese Kinh students participated in the study and donated their blood.