In difficult cases, dapsone 100 to 200 mg orally once a day, indomethacin 150 mg orally once a day for 1 week and 100 mg orally once a day for 2 additional weeks, clofazimine (eg, 200 mg orally once a day for 4 weeks then 100 mg / day for 4 weeks), or cyclosporine (eg, 2 to 4 mg / kg orally 2 times a day) can be given.