Objectives: Determine the prevalence of skin diseases and related factors among workers in Public Services Company in District 6 and District 8, Ho Chi Minh City Methods: Descriptive Crossectional, study on 402 workers working in the Public Services Company in District 6 and District 8, Ho Chi Minh City, during the period from May to July, 2010 Results: The prevalence of skin diseases was 53.2%, rank from highest to lowest: skin pigmentation disorders (hyperpigmented) occupied 21.9%, infectious skin diseases was 19.4% (nail mycosis 7.0%), other skin diseases was 16.9%, skin allergies 8.5%, and acne vulgaris 3.5%.