Other novel treatment strategies include enasidenib, an isocitrate dehydrogenase-2 (IDH2) inhibitor, or ivosidenib, an isocitrate dehydrogenase-1 (IDH1) inhibitor, which may be useful for adult patients with relapsed or refractory AML who have an IDH2 or an IDH1 mutation, and gemtuzumab ozogamicin, which may be used as monotherapy for relapsed or refractory AML.