General Principles of Poisoning By Gerald F O'Malley, DO, Grand Strand Regional Medical Center; Rika O'Malley, MD, Grand Strand Medical Center Reviewed / Revised Jun 2022 | Modified Sep 2022 View Patient Education Symptoms and Signs Diagnosis Treatment Prevention Key Points More Information Topic Resources Substances Usually Not Dangerous... Common Toxic Syndromes Common Specific Antidotes Guidelines for Chelation... Poisoning is contact with a substance that results in toxicity.