Background: Nowsday occupational stress (OS) has been a topical problem concerned in many countries, especially at jobs standed by a lot of pressure, such as nurses at hospitals. Objectives: to identify the proportion of nurses who got OS at Cantho Central Hospital (CCeH), Cantho City Hospital (CCH) and Chau Thanh District Hospital, Hau Giang Province (CDH) and some related factors. Method: A cross sectional study was conducted from 1/3/08 to 15/4/08.