MTHFR C677T and MTR A2756G mutant alleles were found to be significantly more prevalent in patients than controls (p > 0, 05), which led to an increase in the risk of recurrent pregnancy loss as 2.33 and 1.82 fold (OR 2.33; 95% CI, 1.38 - 3.96 and OR 1.82; 95% CI, 1.02 - 3.29), respectively.