Granuloma Annulare By Julia Benedetti, MD, Harvard Medical School Reviewed / Revised Apr 2022 | Modified Sep 2022 View Patient Education Etiology Symptoms and Signs Diagnosis Treatment Key Points Topic Resources Granuloma Annulare Granuloma annulare is a benign, chronic, idiopathic condition characterized by papules or nodules that expand peripherally to form a ring around normal or slightly depressed skin.