Pathologic hyperbilirubinemia in term infants is diagnosed if Jaundice appears in the first 24 hours, after the first week of life, or lasts > 2 weeks Total serum bilirubin rises by > 5 mg / dL / day (> 86 micromol / L / day) Total serum bilirubin is > 18 mg / dL (> 308 micromol / L / day) Infant shows symptoms or signs of a serious illness Some of the most common pathologic causes are Immune and nonimmune hemolytic anemia Hematoma resorption Sepsis Hypothyroidism Table Evaluation of Neonatal Hyperbilirubinemia History History of present illness should note age of onset and duration of jaundice.