Acid-Base Regulation By James L Lewis III, MD, Brookwood Baptist Health and Saint Vincent's Ascension Health, Birmingham Reviewed / Revised Jul 2021 | Modified Sep 2022 View Patient Education Acid-Base Physiology Acid-Base Balance Topic Resources Henderson-Hasselbalch Equation Overview of Physiologic pH.. Overview of Buffering and... Overview of the Role of the... Metabolic processes continually produce acid and, to a lesser degree, base.