Adverse prognostic factors include Lymph node involvement Large tumor size and volume Deep cervical stromal invasion Parametrial invasion Lymphovascular space invasion (LVSI) Nonsquamous histology Treatment of Cervical Cancer Surgery alone for microinvasive disease Surgery or curative radiation therapy if there is no spread to parametria or beyond Radiation therapy and chemotherapy (chemoradiation) if there is spread to parametria or beyond Chemotherapy for metastatic and recurrent cancer Treatment of cervical cancer may include surgery, radiation therapy, and chemotherapy.