The patients with morning surge that increased the risk cardiac organ damage OR = 3.6 (95% CI: 1.1 - 11.4, p=0.02), brain OR = 2.8 (95% CI: 1.0 - 8.1, p=0.04), eyes OR = 2.9 (95% CI: 1.1 - 7.4, p=0.02), there was no effect of morning surge hypertension on kidney damage.