Objectives: To report the effectiveness of the use of iNO in 3 cases with congenital diaphragmatic hernia having pulmonary hypertension in neonatal intensive care unit in Children's Hospital 2.Methods: Cases series. Results: INO (inhaled nitric oxide) therapy showed results of reduce in pulmonary blood pressure and improvement in blood oxygenation status in all three cases with congenital diaphragmatic hernia reported.