Thus, it could also make sense to use pyridostigmine during the long latent period after suspected exposure to A-series agents. However, because pyridostigmine also is an acetylcholinesterase inhibitor, it should not be given after the onset of cholinergic crisis or even if the heart rate or core temperature decreases by > 25% from baseline during the latent period; such patients should be treated for cholinergic crisis.