7-Day Reactogenicity (over a 7-Day Period Post-injection) - Phase 2 and 3 Local or Systemic Reactogenicity Placebo 15 mcg vaccine Giá trị p n (%) (95% CI) n (%) (95% CI) st injection, n 205 625 Any local reaction 41 (20, 0) (14, 75 - 26, 14) 492 (78, 7) (75, 30 - 81, 87) <0, 001 Any systemic reaction 88 (42, 9) (36, 05 - 50, 01) 352 (56, 3) (52, 33 - 60, 25) 0, 001 nd injection, n 201 615 Any local reaction 27 (13, 4) (9, 04 - 18, 94) 271 (44, 1) (40, 10 - 48, 09) <0, 001 Any systemic reaction 48 (23, 9) (18, 16 - 30, 39) 160 (26, 0) (22, 59 - 29, 67) 0, 546 Over the 7-day period following the first injection, solicited local reactions were reported for 78.7% of subjects in the 15 mcg vaccine group compared with 20.0% of subjects in the placebo group.