The results showed the mean G6PDH deficiency rate of 3 provinces were 1.47% (with qualitative method) and 1.51% (with quantitative method); the highest deficit rate in Ninh Thuan (2.12%) and lowest in Đak Nong (0.51%); in male was 2.5 - 2.7 times higher than female gender; G6PDH deficiency rate between minority ethnic groups were different with Tày, Ragley and K'dong were 2.25%, 2.18, and 2.05%, respectively; especially lowest deficit rate in Kinh grouP.