Diagnosis of Non-Hodgkin Lymphomas Lymph node biopsy Often unilateral bone marrow aspiration and biopsy FDG-PET / CT of chest, abdomen, and pelvis for staging MRI of brain and / or spinal cord if neurologic symptoms are present As with Hodgkin lymphoma, non-Hodgkin lymphoma is usually suspected in patients with Painless lymphadenopathy Adenopathy detected on a chest x-ray or CT done for other reasons Painless lymphadenopathy can also result from infectious mononucleosis, toxoplasmosis, cytomegalovirus infection, primary HIV infection, or leukemia.