Many drugs cause mental symptoms; the most common classes of drug causes are Central nervous system-active drugs (eg, antiseizure drugs, antidepressants, antipsychotics, sedative / hypnotics, stimulants) Anticholinergics (eg, antihistamines) Corticosteroids Numerous other therapeutic drugs and drug classes have also been implicated; they include some classes that may not ordinarily be considered (eg, antibiotics, antihypertensives).