Clostridioides (formerly Clostridium) difficile - Induced Diarrhea (Pseudomembranous Colitis) By Larry M Bush, MD, FACP, Charles E Schmidt College of Medicine, Florida Atlantic University; Maria T Vazquez-Pertejo, MD, FACP, Wellington Regional Medical Center Reviewed / Revised Jun 2023 View Patient Education Pathophysiology Symptoms and Signs Diagnosis Treatment Key Points More Information Toxins produced by Clostridioides difficile strains in the gastrointestinal tract cause pseudomembranous colitis, typically after antibiotic use.