Diagnosis of EGPA Clinical criteria Routine laboratory tests Echocardiography Biopsy The 2012 Chapel Hill Consensus Conference (1) defined eosinophilic granulomatosis with polyangiitis (EGPA) as an eosinophil-rich and necrotizing granulomatous inflammation involving the respiratory tract with necrotizing vasculitis of small - and medium-sized vessels in association with asthma and eosinophilia.