Therefore, we present a review of the key recommendations for HE in patients with cirrhosis based on EASL (The European Association for the Study of the Liver) and AASLD (American Association Study of Liver Disease) guidelines regarding definition, epidemiology, pathogenesis, staging, diagnosis and therapy of Hepatic Encephalopathy on patients with cirrhosis) on the definition, epidemiology, pathogenesis, classification, diagnosis and treatment of hepatic encephalopathy in patients with cirrhosis.