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[Assistant] So, you know, that was in my first book that came out in 1993. I've written 10. And it was in my very first one about people being ripped off by movers.


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[Assistant] It is a Clark Rages moment. Larry, we got to find out more from you who the insurer is, the language, because


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[Assistant] That is a fantastic thing for me to do on television and draw attention and shame to ensure that we do that.


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[Assistant] Back with him. Wow! There is no legitimate reason that an insurer


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[Assistant] Should be reading your stuff on your computer. Period.


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[Assistant] So alright, so there's two catches and you want to know does the state of Washington stand behind the plant?


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[Assistant] Back during the banking scandals that led to the financial crisis from 7 to 12, there were a handful of states that had, uh, state prepaid tuition plans.


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[Assistant] That when the guarantee plans went insolvent.


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[Assistant] The states did not step forward to guarantee people's money. And I don't know that that's an issue today, but you just want to know from the Washington State prepaid tuition plan, does it have the full faith and backing from the state of Washington? Or how do they ensure that your money is safe that you put in to prepaid tuition? The second thing is you have to convince your child


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[Assistant] And don't start brainwashing them.


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[Assistant] That they're going to University of Washington or Washington State or whatever, just that they need to go to a state school in the state of Washington because that's what you paid for. And I think, uh, certainly today's kids going to college so appreciate


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[Assistant] That they won't have to have any student loans, that they're like, okay, I'll be happy to go to University of whatever. And just as long as you're really confident, your child will do that and stay in state.


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[Assistant] It's great to do the prepaid because you know you're done.


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[Assistant] So cell phone carriers used to do a thing where once you were locked to their system,


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[Assistant] They would never unlock you forever. The rest of your life, they would not unlock the phone. So that led to new federal rules that the FCC published several years ago that give a distinction that is confusing


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[Assistant] But if your cell phone carrier is a prepaid carrier, they are allowed


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[Assistant] To keep your phone locked. Not all do, but they're allowed.


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[Assistant] When you buy a prepaid phone from a prepaid carrier, you're not obligated to keep service with them. So a lot of people, and they...


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[Assistant] Uh, tend to subsidize the cost of those phones you buy. So what, there was a, a meaningfully large business with people that were buying phones from the prepaid carriers, unlocking them, and then reselling them typically outside the United States. And so it was a big cost for the, uh, prepaid cell phone carriers. So the compromise the government came up with


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[Assistant] With their what are called postpaid services where you're billed after the month that has occurred for your service. Each carrier is allowed to have its own policies on it, but they can never extend longer than when you have paid off the phone. And once you paid off the phone,


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[Assistant] They have to unlock it. If you, let's say you were on payment plan. Once you finished paying that off, they have to unlock your phone.


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[Assistant] So I'm assuming in your case, Nicholas, that your phone was from a prepaid carrier.


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[Assistant] But if you want to see if whoever you're with is violating the rules, it's not the easiest reading in the world.


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[Assistant] But you can read the FCC rules and they have a section that deals with when


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[Assistant] I wanted to ask you, did you know we have a daily newsletter about your money? You know what the cost of it is? Zero money. It's free! So you can subscribe anytime at Clark.com slash newsletter.


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[Assistant] Can I ask you a question about that? Just I've heard from people. What about the concept of a hedge against inflation by owning versus renting?


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[Assistant] Here's what my insurance company stated. Please note that once a driver is excluded, they will not be covered under this policy as outlined.


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[Assistant] That this means that if they choose to drive any motor vehicle, they risk being an uninsured motorist. Does this mean he cannot drive any car, even if he's visiting my sister in New York? And are there any auto insurance, is there any auto insurance that he can buy only for the days he's in Los Angeles, maybe a week a year?


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[Assistant] This is from Debbie in Georgia, is True Bill a trusted site to find out what subscriptions I'm paying for?


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[Assistant] No shame in telling us Luke Skywalker lost his right hand and Rocky got beat by Apollo Creed. The comeback is always stronger than the setback.


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[Assistant] Oh my gosh, how many years ago was that? I don't know, fifteen?


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[Assistant] Well, we talked, we had a, we had a question very recently about someone who had an issue with a charge back and then they were, uhm,


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[Assistant] Uhm, apparently it's centered in his rental and something got messed up and somehow he was jailed for that long. It's just crazy.


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[Assistant] They're saying the majority of cases is when someone doesn't turn a car back in when the rental period is over.


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[Assistant] Okay, you hit two topics. Uhm, Josh in Tennessee says I recently went to file my taxes using the IRS's website and they now require access to your credit report and biometric data information through their ID.me accounts.


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[Assistant] While I understand that they are trying to increase security, this seems extremely invasive. Am I overreacting to this, or am I justifiably concerned?


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[Assistant] This is from Katie in Maryland. You've mentioned many times that the taxes are low right now, so should we pursue a rollover to the Roth IRA, which we both have set up?


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[Assistant] But the balance will most likely grow because this would be three plus years away.


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[Assistant] And we've been getting a lot of questions like this one from Daniel in Oregon from different states around the country. I own a gym and was shut down multiple times. I'm still waiting for my unemployment. I've called and written multiple times and they just keep telling me to submit a contact form.


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[Assistant] Oregon has had millions of dollars of fraud, but I can't get my legal unemployment. I'm wondering if there's someone I can talk to that can actually help me.


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[Assistant] Well, it really helps us cause it makes the podcast show up higher. So it really helps us to grow. So we're so appreciative and lots of people have been


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[Assistant] Uh, reviewing the podcast, Late Line Apple Podcast, which is extremely helpful. And this one was from Missy, who is an RN in Florida. Part of her review said, I still learn so much every time I listen. Clark's commitment to not selling out is rare in our money-first society.


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[Assistant] I'm getting some emails. My dad said that the, the internet is really, really, really spotty. So I've gotten a couple emails and texts, but they've had, uh, two ports canceled and then they rescheduled one to a port that they weren't originally going to. So, so far, sounds like they're doing okay.


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[Assistant] But the only reason I could see it is if you have other people in your cabin and you're trying not to be exposed to them, maybe lock you in a different room, I don't know, but that's the only case that I could see.


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[Assistant] That looks really rough. Alright, I do have a few travel questions. Wait, I'm sorry, I didn't talk about Airbnb.


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[Assistant] Some travel questions. Joe in Georgia, we planned a 40th anniversary trip to Canada last year that's scheduled to start next month. The complete first class itinerary has been modified since our original trip payment was completed.


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[Assistant] All bars and restaurants are closed. The dome car and special first class amenities have been cancelled.


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[Assistant] We want to cancel the trip, but the tour company said the third party insurance will only refund three quarters of the $11,000 price tag. This is not right or fair. I know it's COVID and masks would have been okay, but nothing will be open.


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[Assistant] We would have first class meals on paper plates, no bubbly or alcohol. It would not be a trip to remember.


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[Assistant] And we'll squeeze in one more here from Phillip in Connecticut. I'm trying to rebook a trip overseas, which I first booked in December of 2019 and again after the vaccines were announced last year.


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[Assistant] Most of the plane tickets are covered through my travel credit with United.


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[Assistant] My question has to do with insurance. I've seen cancel for any reason policies, which is also good because we have elderly parents.


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[Assistant] However, they'll only cover 75% of the non-refundable amount. If United gives us a credit,


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[Assistant] I may only be on the hook for a couple of hotel nights. Am I right about the plane tickets? If so, I'm not sure it's worth buying the cancel for any reason coverage.


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[Assistant] Well, I've got a question from George in California. He says, I bought an oven from a big electronic retail store in July of 2021. I'm still waiting for delivery.


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[Assistant] The delivery date has been adjusted three times already. The last promised delivery is for February 5th.


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[Assistant] As part of the purchase promotion I received no interest credit for 24 months. I called the store and asked if they would extend the interest free promotion


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[Assistant] Devil's advocate, if I went to that store and ordered the oven, I would have to pay for it when I ordered it.


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[Assistant] This is from Dennis in Georgia. I'm a coach and receive multiple payments weekly via Venmo for private lessons. With the new IRS reporting requirements do I need to report since there's no receipt or bill given to the payee?


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[Assistant] I'm David in New Jersey. I have relatives who just moved here from India and I'm helping them get settled in. They have their social security cards and are working on getting driver's licenses. I add them as authorized users on my credit card as well.


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[Assistant] However, it's a little tough to get them a bank account. I tried opening one with an online bank but they were unable to verify their identities. Do you have any suggestions of how or where I can open a bank account for them?


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[Assistant] That's okay. This is from Debbie in Colorado. I've heard your tips on hiring a professional moving company.


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[Assistant] But I've never heard you talk about using moving pods. I need to move from Colorado to Arizona and I'm considering using a pod container and hiring local labor to help me pack and unpack the pod with the heavy items. This seems to be a lower cost option and I'd love to hear your thoughts on this approach.


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[Assistant] You can also use them if you need to store stuff. It's a great method to if you're in between moves or you're fixing up the new place or whatever.


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[Assistant] I do. This is from Jay in Texas. He says, I'm looking to change from Sam's to Costco. One of the reasons is because it's closer to my house and the other is because everyone says it's better. But what's the difference between the basic plan and the elite?


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[Assistant] But I do want to say, Sam's Club and Costco, they're often specials if you are not a current member, and we always put those on ClarkDeals.com, but you can find them on their website.


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[Assistant] This is from Michelle in Virginia. We have a car with a lease expiring in September. We're planning on purchasing the lease. Currently the car is worth $10,000 over the lease buyout price if bought today.


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[Assistant] Should we wait until the expiration to purchase it out or are there any advantages to buying it early with the extra equity in the car given the used car market?


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[Assistant] And this is from Amy in South Carolina. My son scored a 1530 on the SAT at the very beginning of his sophomore year of high school, just shy of turning 16.


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[Assistant] This put him on the radar for many colleges. He's received invitations to participate in summer immersion programs from elite schools.


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[Assistant] I'm guessing there may have been even, there may even be more to come. These cost from $2,800 to $19,000 for a week long program to an all summer program.


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[Assistant] My question is, are any of these programs worth the cost? And I have to say, like, I'm getting, I think, you know, a lot of these, uhm, programs do start sending out solicitations this time of year.


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[Assistant] I have to counterpoint that with I do want my kid to go to a summer college program for at least a few weeks. Our daughter did it and it really helped her to figure out what kind of campus she wanted to be on. The program she went to took them to different colleges to see them and she had an experience kind of being far away from home.


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[Assistant] And, and we did really find it helpful. It is expensive and then she worked the rest of the summer. So sometimes I feel like it can be appropriate just depending on your situation and your kid.


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[Assistant] Well, I thought you were going to say Costco because I know you went to a Costco in New Jersey.


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[Assistant] How can I determine which are legit or created just to provide the mortgage company with some additional profit?


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[Assistant] For $800,000, one of your favorite insurance companies has now concluded that the replacement cost is $1.4 million, making the insurance cost very high. I can shop around of course, but how do I get an accurate replacement cost neither too high nor too low?


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[Assistant] That's such a good reminder. Like, I'm thinking I need to look again at our replacement cost and make sure it's high enough, uh, because of the prices now. I hadn't even remembered to do that.


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[Assistant] Time and dealing with all that stuff, it wasn't fun, but uhm, we did, you know, we dug out of it, and uhm, I'm kinda grateful for the experience now, but yeaah, you should always make sure you have enough coverage for sure.


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[Assistant] It's not my heart, I just feel like it's, you know, the tough things are what make us stronger, right? Like you can always see, like in hindsight, of course, like at the time it was a year out of the house and a lot of stuff going on, but, uh, we were so lucky you and so many other friends and family and our church were so good to us and,


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[Assistant] Uhm, and it was like, we realized how little all that material stuff meant, and so now I have a different perspective.


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[Assistant] Duke fans, what's up? This is Ryan Young back, uh, episode 9 of the Brotherhood Podcast. We have a special edition today, uh, with the four freshmen here. Can you guys go ahead and introduce yourselves?


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[Assistant] Uh, who are your rooms in? Who's, who are you saying, what room are you in last year? Like, who's the guy?


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[Assistant] Let's go back, uh, to pre-summer, uhm, to high school. Who had the best high school career out of you four?


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[Assistant] Who do you think, we'll get back to the high school thing, do you think anybody on the team could hit a ball off you? Me. No, definitely not.


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[Assistant] Alright, so you guys all play high school basketball in different areas of the country and you start being recruited by Duke.


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[Assistant] I think so too. You guys show up on campus in the summer.


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[Assistant] And it's the first time you're here. Give me the initial takes for each of you on the summer, uh, just in general, you know, how have you liked it? Has it been different than what you thought it was going to be?


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[Assistant] You guys are, and everybody's been talking about it this summer, but in my opinion, I've been around a lot of college basketball. Definitely the hardest working freshman class that I've seen.


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[Assistant] What else, uh, I know there's a ton of video games being played. Are you guys mostly just playing Madden and 2K? Honestly, the biggest...


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[Assistant] Let's move into what you guys are excited about for this year. The real thing that we've been through.


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[Assistant] What about this, uh, this upcoming, I mean, I'm sure you guys are talking about, uh, Countdown.


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[Assistant] I just don't wanna go first. I'm gonna try to be really creative. One of you's going first. We think Jared should go first.


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[Assistant] What about other stuff off the court you guys are excited about? First time being college students.


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[Assistant] Uhm, let's talk about the mindset for you guys as a class coming in.


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[Assistant] Obviously, Duke, over the past whatever decade or so, freshmen have been such a prevalent part of going deep in the season and winning. Uhm, what kind of mindset do you guys have individually and as a group going into these games in the season?


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[Assistant] Uh, versus T.J. and Jared. And I have 10 questions. Each team's gonna give 5. And if you get it wrong, you're gonna have about 20 seconds to think about it. If you get it wrong, the other teams will have a chance to steal, alright?


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[Assistant] Similar enough, but the trivia is Duke basketball freshman trivia. Okay? Duke basketball. How about each other?


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[Assistant] That's correct. Uh, bonus point, who was picked in between them?


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[Assistant] They're both wrong. You have a chance to steal her. You guys are down too, aren't you?


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[Assistant] Two? Yeah. Okay. Do you know who number one is? You wanna take a guess? You got five seconds.


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[Assistant] Five Blue Devils have won National Freshman of the Year. Name at least three.


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[Assistant] Okay. Zion. Zion's one. Fresh from the other year. Jabari. Jabari's one. It's two. Give me one more. One more. Jaleel Okafor. Jaleel Okafor counts as three. Yes. It's four to one. I would give you guys.


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[Assistant] An extra point, if you could just name one of the other ones. There's two others, just name one.


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[Assistant] Ah, incorrect. Vernon Carey would have worked or Luau Dang.


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[Assistant] Well, five to one here. It's going back to you guys. Number nine, Caleb and Sean. Who was Coach K's first McDonald's All-American?


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[Assistant] All the years of Duke. You can't count them. That's too many. I mean, you're not gonna go back. And it's like, there's some old guys.


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[Assistant] Welcome to the Lifespan Podcast, where we discuss the science of aging and how to be healthier at any stage of life.


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[Assistant] I'm David Sinclair. I'm a professor of genetics at Harvard Medical School and I'm also co-director of the Paul F. Glenn Center.


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[Assistant] For biology of aging research in this podcast series, we're talking about why we age.


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[Assistant] And how to slow stop and even reverse that process to give us longer and healthier lives. In this episode, this final episode of the eight part series, we're talking about the very near future. What's coming down the line that will potentially greatly extend our lifespans. I'm joined here by my lovely cohost and my coauthor of lifespan, Matthew Laplante. Welcome.


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[Assistant] So yeah, we've been talking over the last few minutes about what the future really looks like and how much it's going to change our lives. But even.


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[Assistant] How hard it is to predict the future just a few years out because things are changing so quickly.


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[Assistant] We even have this illustration in the book of a person going online, doing a telemedicine.


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[Assistant] Uh, interview with a doctor and having medicines delivered to their home.


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[Assistant] In that case by drones, but we're pretty much already there thanks to the pandemic.


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[Assistant] And even when we wrote the book, there was pushback even within our conversations. How realistic is it that people will take their own?


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[Assistant] healthcare medical care into their own hands and would they be allowed to and we've been rapidly pushed into that world where


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[Assistant] You can take home tests for pretty much anything. You can have blood tests for pretty much anything. Of course doctors have to be involved, but you don't have to go see a doctor.


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[Assistant] Right. And in the future, it's going to be rare to go to see your doctor. Most of it's going to be done remotely and you won't even know the doctor that's involved in prescribing something.


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[Assistant] Well yeaah, I was pretty sure I would get sicker when I went to that waiting room with people coughing and sneezing everywhere. Hospitals are just as bad. It's pretty risky. Particularly as an older person going to the hospital.


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[Assistant] And if you don't need to, if you can be monitored at home, which is increasingly possible.


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[Assistant] Then a lot of people won't die from an infection that they would typically get at the hospital.


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[Assistant] Yeah. And before we get to that, this podcast is made available freely. And the reason is we have sponsors that


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[Assistant] Help us monitor our bodies and keep the nutrition at the right levels based on that feedback. Our first sponsor is levels.


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[Assistant] Levels is an app that syncs with a continuous glucose monitor which they provide and interprets your glucose data for you.


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[Assistant] I've been so impressed using Levels that I recently joined the company as a scientific advisor.


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[Assistant] By monitoring your blood glucose levels allows you to see how different foods affect you.


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[Assistant] I've had fun running tests of my own, seeing how different foods impact my blood sugar levels.


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[Assistant] For example, I've learned that white rice really spikes my blood sugar, whereas potatoes don't.


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[Assistant] As we've discussed on this podcast, having stable blood glucose is very important.


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[Assistant] Not only for daily mental and physical energy, but also for long term health.


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[Assistant] So if you'd like to try levels, you can skip the 150,000 person waitlist.


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[Assistant] And go there straight to the top of the line and join today by going to levels.link slash Sinclair.


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[Assistant] That's levels.link slash Sinclair. Today's episode is also brought to us by Athletic Greens.


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[Assistant] Athletic Greens is an all-in-one daily green string that supports better health and peak performance.


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[Assistant] It's developed from a complex blend of 75 vitamins, minerals, and whole food sourced ingredients.


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[Assistant] It's filled with adaptogens for recovery, probiotics, prebiotics, and digestive enzymes for gut health, along with vitamin C and zinc citrate for immune support.


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[Assistant] I've been drinking athletic greens each morning for a number of years now as a way to cover all my nutritional bases. I'm often traveling, sometimes my diet isn't the best and as what happened today,


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[Assistant] We ran out and it was really painful not having a start of the day with athletic greens.


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[Assistant] So if you'd like to try Athletic Greens, you can go to athleticgreens.com slash Sinclair and claim a special offer.


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[Assistant] They're giving five free travel packs plus a year supply of vitamin D3 for immune support and vitamin K2, which keeps the calcium out of your arteries and keeps it in your bones where it belongs.


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[Assistant] Again, go to athleticgreens.com slash Sinclair, my last name, to claim this special offer.


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[Assistant] Today's podcast is also brought to us by InsideTracker.


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[Assistant] InsideTracker is a personalized nutrition platform that analyzes data from your blood and your DNA.


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[Assistant] to help you better understand your body and reach your health goals. I've been using inside tracker for over a decade and I'm the chair of the scientific advisory board.


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[Assistant] The reason I've long used InsideTracker is because they provide the best blood and DNA analysis that I'm aware of.


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[Assistant] Or like I do, have someone come to your home. It's really convenient. From there, InsideTracker analyzes your data and presents that data in an easy to understand way. Another feature that InsideTracker offers is their inner age test, which I helped develop. This test shows you what your biological age is, how it compares to your chronological age, and what you can do to improve that number. So if you'd like to try InsideTracker, you can visit them at insidetracker.com slash Sinclair and then


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[Assistant] You'll get a 25% discount off any of their plans. Use the code SYNCLARE, my last name, at the checkout.


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[Assistant] Doctors had no way of knowing if you're sick other than asking you how you feel and they couldn't do that remotely. Certainly not through video, but they also needed to feel you and to take samples in the office.


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[Assistant] Right now you can wear a biosensor, a monitor, or do a blood test from home or a local clinic that will give the doctor.


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[Assistant] Way more information than they could ever get by seeing you in person.


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[Assistant] So a case in point, I saw my doctor maybe six months ago and I hadn't seen him for a year and it was a video conference and it was a very, it was supposed to be very quick, 10 minutes. He said, David, how do you feel? Feeling good. How are you sleeping? Not so good. Well, you should get more sleep. Try to not do your emails too late.


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[Assistant] Uhm, anything else you want to talk about? And I said, yeah, there's a lot. I'm, I'm, you know, I'm 52. I could have colon cancer. I could have all these other issues. Let's do some tests. And he says, well, okay, what kind of tests do you want? So I said, uhm, what about a prostate cancer test? From my age, it could be, I could have prostate cancer. My neighbor just died from prostate cancer. And he said, well, do you have a family history? Not that I know of. Do you feel sick?


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[Assistant] No, because well then there's no need to do the test. I said, hold it right there. Hold it right there. Are you telling me that I need to have a large tumor in my prostate that's causing me to be sick before I come and see you? And he said, yeah.


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[Assistant] And it's often too late, then I'm on my way to death. So these days there are tests that you can do that your doctor can order.


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[Assistant] There's a new one that's just about to be released by a company called Grail. That and there are many others that can with a finger prick or a little blood test from a local clinic


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[Assistant] You can detect 50 different types of cancers before they even become tumors and kill them years before they would show up and have you go to a doctor, which is often too late.


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[Assistant] Well that's right, and they give off a lot of different signals out of the breath.


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[Assistant] And in the bloodstream, they leach proteins, they leach DNA.


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[Assistant] R and A and even the types of DNA that come out this little fragments.


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[Assistant] They have little ends. They're not, it's not the whole chromosome that comes out. They get chopped up. The cancer cells die and out come these little pieces.


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[Assistant] Those pieces have chemicals on them, the DNA methylation.


[User] Please transcribe this text

[Assistant] The clock that can be read and even at the ends how they were caught up by enzymes in the cell can tell you indeed that is a stage one liver cancer, even though we picked it up in the bloodstream.


[User] Please transcribe this text

[Assistant] Exactly. So with, with the cancer, we've been slowly reducing, uh, the incidence of cancer and particularly the ability to survive cancer and it's been.


[User] Please transcribe this text

[Assistant] We haven't cured cancer, but it's gotten a lot better, particularly for diseases like breast cancer, lung cancer too.


[User] Please transcribe this text

[Assistant] What I'm excited about is that this new development that's not come from oncologists but from people who develop these tests, the geneticists that can find blood, what's called circulating DNA.


[User] Please transcribe this text

[Assistant] This is going to dramatically reduce the incidence of cancer.


[User] Please transcribe this text

[Assistant] And certainly the death rate. Why? Because if you catch a tumor when it's small.


[User] Please transcribe this text

[Assistant] You take some chemotherapy and you kill it off before it spreads and it's too late.


[User] Please transcribe this text

[Assistant] Coming along that'll be added to those blood tests is the ability to measure your heart's function. So I'm, I wear a device, uh, that's right here. This is, uh, this one's called a bio button. You can see it's about an inch.


[User] Please transcribe this text

[Assistant] So instead of going to your doctor once a year for an annual checkup, this thing's monitoring my body a thousand times a second.


[User] Please transcribe this text

[Assistant] For vibration, it can hear me how I speak, how I cough. It's looking at my movements, how I sleep during the day, how I move. But most importantly for this device, it's measuring my heart.


[User] Please transcribe this text

[Assistant] In many different ways. It's actually an FDA approved EKG. This is something that used to have, you have to put stickers all over your body that doc used to measure it, sine waves and whatever. You can now do it with your wristwatch, though that's not FDA approved.


[User] Please transcribe this text

[Assistant] This one is the real deal. Doctors use this information to diagnose patients.


[User] Please transcribe this text

[Assistant] And what's been, is being used for mainly now is to send patients home early who have experienced a heart attack or have had heart surgery.


[User] Please transcribe this text

[Assistant] Just to see if they're doing alright at home and hospitals save tens of thousands of dollars that way for something that only costs about $20.


[User] Please transcribe this text

[Assistant] This device will send a note to my doctor or nurse that's scanning


[User] Please transcribe this text

[Assistant] Hundreds and eventually millions of, of people.


[User] Please transcribe this text

[Assistant] And there'll be a red alert be like minority report. I've seen this actually in development. You call it up. Here's David's heart. Um, and the kidneys are also having an issue. The doctor then looks at it. It's probably.


[User] Please transcribe this text

[Assistant] Or she is playing a golf game or doing something else, but they can see it. They go, okay, this person's about to have a heart attack. Send in the.


[User] Please transcribe this text

[Assistant] Yeah, this is the levels continuous glucose monitor. It's on the, on our arms here. And, uh, we've been playing with this the last week.


[User] Please transcribe this text

[Assistant] Together we've been competing to see who's got the lower blood sugar levels.


[User] Please transcribe this text

[Assistant] Right, but we're both healthy and what we've learned by eating meals together over this past episode is


[User] Please transcribe this text

[Assistant] That what we eat really makes a big difference. So things like rice and grapes for me really spike it.


[User] Please transcribe this text

[Assistant] Uhm, potatoes not so much. Have you learned anything with this device?


[User] Please transcribe this text

[Assistant] Exactly. And it's similar to scales in your bathroom.


[User] Please transcribe this text

[Assistant] It's known that if you're told to weigh yourself every morning, you will lose weight more often than not. And I liken these to.


[User] Please transcribe this text

[Assistant] You do, you do, uhm, and, you know, until further studies are showing that they're safe, you know, that's a reasonable thing. But I do...


[User] Please transcribe this text

[Assistant] Exactly. So right now there are those, there are some in the medical establishment that think that these should only be used for diabetics. My argument is a bathroom scales only for those who are


[User] Please transcribe this text

[Assistant] Morbidly obese? No. Anybody can use them to tell more about their bodies and how they can improve.


[User] Please transcribe this text

[Assistant] Send in a sample of blood and have your glucose measured and that's how it's been done for really up until these devices came along.


[User] Please transcribe this text

[Assistant] Uhm, increasingly we're now seeing wearables being able to do it. Watches.


[User] Please transcribe this text

[Assistant] Uhm, these semi-invasive needles. Eventually what we're going to have is the ability to incorporate it into one of these stickers. Uhm, and not just one measurement, but hundreds.


[User] Please transcribe this text

[Assistant] Yeah, there's an interesting point that it's kind of the end of the story about my doctor.


[User] Please transcribe this text

[Assistant] Even though my doctor was reticent and eventually capitulated and gave giving me that prostate cancer test. Thank you, Dr. Peter.


[User] Please transcribe this text

[Assistant] It is. And there are countries that have realized this. So Australia provides sunblock on beaches. They also provide free colon cancer tests. You just poop and send it off.


[User] Please transcribe this text

[Assistant] Said was, oh, you have all this data from inside tracker.


[User] Please transcribe this text

[Assistant] Let's look at it. So I call up on the screen all the data and he's loving it.


[User] Please transcribe this text

[Assistant] At least in the case of my doctor, he's not upset that I'm measuring myself. In fact, he would do it for everybody if the insurance would pay for it.


[User] Please transcribe this text

[Assistant] Well, exactly. And it's just the beginning of being cognizant of that your body matters and is changing all the time. And there are days and months where it's going to be way out of whack.


[User] Please transcribe this text

[Assistant] And you wouldn't know unless you were measuring it. It's all about, as we wrote in lifespan, the book.


[User] Please transcribe this text

[Assistant] You need a dashboard for your body in the same way you need a dashboard for your car. You wouldn't drive your car without a dashboard. Well, you could, but you wouldn't get very far. You'd run out of gas. We need that for our bodies and it's really time that we do that.


[User] Please transcribe this text

[Assistant] And what we'll have is a massive reduction in diseases like all cancers but colon cancer already. We're going to have heart attacks.


[User] Please transcribe this text

[Assistant] The thing of the past pretty much cause your doctor will know days in advance before you actually have a cardiac event.


[User] Please transcribe this text

[Assistant] And other things, including depression, anxiety, these can also be measured by the devices that we have on our bodies or even in our hands or the ones we type on. These indicate diseases.


[User] Please transcribe this text

[Assistant] Speaking of typing, you can tell if someone's getting Alzheimer's or Parkinson's just by how they type.


[User] Please transcribe this text

[Assistant] Well, I'm already measuring a lot of those.


[User] Please transcribe this text

[Assistant] There's a molecule called CRP which I always want to keep low because that's a really good predictor of cardiovascular disease.


[User] Please transcribe this text

[Assistant] Uhm, and so we've got glucoceratid protein inflammation, so this would be TNF-alpha or IL-16. These are also predictive of longevity.


[User] Please transcribe this text

[Assistant] Uh, I want cortisol, keep my stress levels down or also telling, telling me if I over exercise. I would love to see your cortisol chart. I have it all. I've got 10 years of data, dude.


[User] Please transcribe this text

[Assistant] Uhm, and then I think that's four. The fifth one, let's see, I would like to know, uh, lactate would be great because that would tell me, uhm, if my body is able to deal with exercise adequately.


[User] Please transcribe this text

[Assistant] And maybe blood oxygen too. So when I'm exercising, making sure that I get hypoxic, which as we've talked about is one of those adversity memetics, uh, that turns on your body. Well, it is an adversity, but it's, it's a hormesis that doesn't kill you, but makes your body stronger in the long run.


[User] Please transcribe this text

[Assistant] Get those from companies. They're not yet commercially available and I've tried these out. Uh, this one will, will measure a variety of things through the skin including analytes, glucose eventually.


[User] Please transcribe this text

[Assistant] There are companies that are including levels that are going to be measuring hundreds of things that include the things that I mentioned. These nanosensors they use, they don't just use these chemical reactions, they'll have antibodies that can detect


[User] Please transcribe this text

[Assistant] You know, it's five minutes, you've recharged this thing and you're good to go and they could stay in you for life.


[User] Please transcribe this text

[Assistant] We were discussing this earlier, we got into a bit of an argument before we went on air.


[User] Please transcribe this text

[Assistant] And maybe you want to hold me, hold me back because this is a longer discussion, but I think that everybody should have a biosensor in their body at every age so that parents, doctors, uhm, can monitor how people are doing and make better decisions about food and lifestyle.


[User] Please transcribe this text

[Assistant] Well, it's going to be a company. The government is not developing these things. Um, and there are many companies doing this, small and large. We know Amazon, Google, Apple, they have their health divisions.


[User] Please transcribe this text

[Assistant] But there are a lot of little startups developing devices that may be acquired or may become the next healthcare giant. It is a problem though that this data is


[User] Please transcribe this text

[Assistant] Is massive. There's terabytes of data that I'm collecting on my body and multiply that by a billion or so people. That's going to be a lot of data. First of all, where do you store it? Who owns it?


[User] Please transcribe this text

[Assistant] What will be done with it? Is it anonymized? Is it under the HIPAA Act? Hopefully in America that will protect it from being used against you.


[User] Please transcribe this text

[Assistant] I was on a podcast with Lex Friedman and he brought up a really important point which was


[User] Please transcribe this text

[Assistant] This is a world that's coming. It's not a question of if, it's just when and it's only the next few years that these rules should be put in place.


[User] Please transcribe this text

[Assistant] Yeah, so every time one of your relatives puts their DNA and their genetic data into a database, it affects you.


[User] Please transcribe this text

[Assistant] Yeah, uhm, and so one of the uses of this obviously is that your family learns about their health, but another


[User] Please transcribe this text

[Assistant] For decades going around murdering people of 13 murders, 50 rapes, 150 burglaries. They finally.


[User] Please transcribe this text

[Assistant] Found a hair from this individual. It didn't have the roots, but there wasn't much DNA, but Ed Green and his team at a company, Australia, that I work with.


[User] Please transcribe this text

[Assistant] Right. So that's why these laws need to be looked at and made sure that they are.


[User] Please transcribe this text

[Assistant] Totally tight so that there cannot be a dictator or some sort of change in government law that can use this data for nefarious purposes.


[User] Please transcribe this text

[Assistant] Right, there will be big decisions to be made by governments as to what is


[User] Please transcribe this text

[Assistant] I'm on the front lines of this as well. I was building a company, have a company called ArkBio that.


[User] Please transcribe this text

[Assistant] In the effort to get ahead of COVID-19, now it came a little too early, we weren't ready, but


[User] Please transcribe this text

[Assistant] We pull out the human DNA and see what's left behind and those are the pathogens and we can


[User] Please transcribe this text

[Assistant] Well, let's go through some of the sensors that are here now and ones that are just about to come on the market. Look at me, I'm wearing the blood glucose monitor, which we've talked about, we love. I've got a ring that measures my sleep and my heart rate and my movement.


[User] Please transcribe this text

[Assistant] Really need to focus on sleep. This helps me. It makes me cognizant of my sleep.


[User] Please transcribe this text

[Assistant] I've got one of these watches that does heart, it does movement walking exercise. So I'm already a bit of a cybernaut.


[User] Please transcribe this text

[Assistant] Well, don't forget that, yeah, this is, this one's not commercially available, but we'll be soon.


[User] Please transcribe this text

[Assistant] Right. So I know a lot about my body and I've actually been getting healthier and fitter over the years because of it. It's no accident and I love.


[User] Please transcribe this text

[Assistant] What I am able to do, I'm a scientist and I can correct things when they're out of whack and not optimal. And I wouldn't be able to do that if I didn't monitor it.


[User] Please transcribe this text

[Assistant] Contact lenses are one area you can measure your blood glucose levels. There are tooth sensors. You can measure bacteria in your mouth. You can also currently


[User] Please transcribe this text

[Assistant] Through Viome and other companies, I was talking to the CEO of Viome the other day, Naveen Jain, he's


[User] Please transcribe this text

[Assistant] Got a colon cancer test that works better than anything on the market, but he also can see health and give you supplements that will improve your health based on what's in your gut.


[User] Please transcribe this text

[Assistant] Yeah, it felt weird going to the shop, to the store with a box full of my poop, but I did it in the case of a colon cancer test, which a lot of Australians are doing just normally, but it is weird.


[User] Please transcribe this text

[Assistant] Gross. But I learned that I didn't have colon cancer, so that was worth it.


[User] Please transcribe this text

[Assistant] Right, and then eventually we'll have these optimized uhm,


[User] Please transcribe this text

[Assistant] Athletes as well. Already they're wearing a lot of devices, but eventually they'll be monitored for all sorts of things. They're like a Formula One racing car.


[User] Please transcribe this text

[Assistant] Doesn't that make sense? Makes sense to me. I wouldn't want to walk around potentially going to have a heart attack tomorrow or having cancer growing me and not know about it.


[User] Please transcribe this text

[Assistant] I want to know this stuff and that's what I think will lengthen our lives by another decade beyond what we're able to do with changes to lifestyle.


[User] Please transcribe this text

[Assistant] There are a number of ways to measure your biological age. I've used InsideTracker for over a decade now to steadily get ostensibly younger, biochemically, over that decade.


[User] Please transcribe this text

[Assistant] I was 48 and it spiked. My age went up based on their inner age test.


[User] Please transcribe this text

[Assistant] And then I changed my lifestyle, I started taking NMN Metformin and got that number in a rage down to 31.4.


[User] Please transcribe this text

[Assistant] In a matter of months, that doesn't mean I was literally that age, just means that my blood biochemistry markers matched somebody that was more like 34.


[User] Please transcribe this text

[Assistant] Yeah, these tests aren't perfect right now. They're fairly expensive. They take weeks to get results, but that's going to change.


[User] Please transcribe this text

[Assistant] Uh, the student in my lab, you know, Patrick Griffin, he's spent his PhD trying to figure out how to make it cheap.


[User] Please transcribe this text

[Assistant] Uhm, and you figured it out, we've just put a paper online, uh,


[User] Please transcribe this text

[Assistant] Viewers can go and download that. It's at a site called bioarchive, uh, Sinclair, Griffin, uh, keyword TimeSeq.


[User] Please transcribe this text

[Assistant] That paper is describing a way to do this methylation clock for a thousand times less. We're spinning out a company. We're in the process of hopefully.


[User] Please transcribe this text

[Assistant] It's drsinclair.com, spell out the word doctor, drsinclair.com and you can get on a wait list.


[User] Please transcribe this text

[Assistant] Do that because the more people we have, the more experiments we can do together to figure out what slows aging and even reverses it.


[User] Please transcribe this text

[Assistant] Yeah, well there are a couple of companies that we're involved with and they support this show.


[User] Please transcribe this text

[Assistant] That tell us what we can eat so levels is telling us what's bad to eat for raising blood sugar and what we should.


[User] Please transcribe this text

[Assistant] The app actually, we were looking at this together, you can compare foods with this app, which is fun.


[User] Please transcribe this text

[Assistant] InsideTracker also provides nutritional recommendations you might want to.


[User] Please transcribe this text

[Assistant] What things to buy at the shop at the supermarket and even what local restaurants you can go to and which meals you should have to optimize your health.


[User] Please transcribe this text

[Assistant] Well, that's what I do. It's not just that you can, you should.


[User] Please transcribe this text

[Assistant] And sort of decisions that you can make are, okay, if you're deficient in vitamin D, you can be directed towards eating certain foods like fish that have vitamin D.


[User] Please transcribe this text

[Assistant] Or if you have certain high levels of cortisol, reduce your stress, do meditation, don't exercise so hard. These are tweaks to your life that otherwise you wouldn't know that you needed to do.


[User] Please transcribe this text

[Assistant] Well, they do. Most of these apps are taking a lot of data. It's often terabytes of data and.


[User] Please transcribe this text

[Assistant] Distilling it down into a few simple steps for you to do each day.


[User] Please transcribe this text

[Assistant] Yeah, that's a key component. It's particularly important for people who are on specialized diets. Say if you're a vegan or vegetarian, you're going to be lacking in vitamin B12, probably. You may have low NAD levels because you're getting older.


[User] Please transcribe this text

[Assistant] You measure those and then you'll have recommendations to supplement and bring those levels back to an optimal level.


[User] Please transcribe this text

[Assistant] They'll probably recommend go get that brand or go get that right now. It's very difficult. You don't know what brands to choose. I'm working on a way to solve that as well.


[User] Please transcribe this text

[Assistant] But ultimately I think what's going to happen is in our homes, we're going to have a machine that can give us a poly pill with.


[User] Please transcribe this text

[Assistant] The minerals, the vitamins, maybe even the medicines that we need right on the spot.


[User] Please transcribe this text

[Assistant] This isn't crazy stuff. Daniel Kraft and MD, a good friend of mine from Stanford University has a company that's built a machine. It's not yet available that does mix those minerals, vitamins, and even medicines right there on your kitchen countertop every morning.


[User] Please transcribe this text

[Assistant] Right, it's not even male and female half the time, but even if it is, it's all men take this, women take that. Not even asking how much volume or how much does that person weigh. We can be, you know, some people three times heavier than others.


[User] Please transcribe this text

[Assistant] It's ridiculous. Right. These pills that are made in the home, they're going to be made especially for you for that day.


[User] Please transcribe this text

[Assistant] Right, and actually medicine, as it's currently called, is based on an average person. And so those ranges that doctors look at to say, oh, you're sick or you're not, are based on an average human. It doesn't take into account your, often your history, your genetics, what you've been eating, how biologically old you are.


[User] Please transcribe this text

[Assistant] And these things should be brought into, brought to bear as well. And eventually doctors will have this information and all be assisted by AI.


[User] Please transcribe this text

[Assistant] But right now we're in that transition zone. And interestingly, the AI is being used by customers, not by doctors so much.


[User] Please transcribe this text

[Assistant] The wristband, this patch, they're measuring my heart rate constantly. They're looking at heart rate variability, which you want to be high. They're also looking at resting heart rate, which you want to be low in general.


[User] Please transcribe this text

[Assistant] There are certain ways to improve that. There's running, there's weights, there's yoga, even meditation.


[User] Please transcribe this text

[Assistant] The apps will soon be so sophisticated they'll say, okay, today you should go on this run here. I'll send you on a map. This will be nice. It's good weather.


[User] Please transcribe this text

[Assistant] Versus uhm, oh maybe today you need a rest, you've got a bit of cortisol, you ran yesterday, do some weights today. And that is going to be optimized.


[User] Please transcribe this text

[Assistant] In addition with the supplements, they're going to say okay, don't take this supplement today because I'm going to tell you to go lift weights.


[User] Please transcribe this text

[Assistant] Pretty much you're going to have a guardian angel for health. And when that happens, you're going to look at the days when we went for an annual physical as though those days are medieval.


[User] Please transcribe this text

[Assistant] Well clearly, and I say this all the time, when I give talks, people ask me, well, what should I do? Tell me what you do, David, and I'll do that. Well, that's not what people should do because everybody's different genetically, physically, even mentally. What I can do, skip meals, some people cannot do. So even though on


[User] Please transcribe this text

[Assistant] As I often say, page 304, I listed what I do in the book.


[User] Please transcribe this text

[Assistant] That's not the perfect prescription for everybody of course because everyone is different. So you got to measure yourself like I do and see what works for you and what doesn't.


[User] Please transcribe this text

[Assistant] In fact, what the data says from my lab is that when you give.


[User] Please transcribe this text

[Assistant] NMN and your exercise, you get the best benefit. So it's not an excuse to sit around and just pop a pill.


[User] Please transcribe this text

[Assistant] But there are, there is a need for better medicines. The reason that I'm developing at one of my companies, a better NMN version is that the elderly and people who just came in with a heart attack or have kidney failure, they cannot be on a fasting regimen easily or asked to go for a run. So you do need to be able to deliver these with a pill or with IV.


[User] Please transcribe this text

[Assistant] But for those of us who are still fit, the best bang for the buck is, at least with today's technology, is to eat right, move right, and supplement.


[User] Please transcribe this text

[Assistant] Well, so Greg Fahey, the professor out in California who's doing this with patients and published with Steve Horvath, they're seeing a couple of years retreat in age in 12 months of treatment.


[User] Please transcribe this text

[Assistant] With a combination of, of three factors that we discussed in an earlier episode, but this is just the beginning. This is the early days of flight.


[User] Please transcribe this text

[Assistant] Uh, we're just learning how this works. But very rapidly over the next few years, we're going to learn what else can reverse the age of the body. Certainly the blood clock, which is what's being used right now.


[User] Please transcribe this text

[Assistant] And there were reports of people going back 10, even 20 years with certain treatments. So this is a golden age for aging research. I didn't realize it when I started out in my career. I didn't expect that.


[User] Please transcribe this text

[Assistant] To be talking about age reversal, I thought, oh yeah, we'll, we'll slow down aging and that'll be the best if we're lucky. We're in a world that.


[User] Please transcribe this text

[Assistant] Right. So we're talking about a gene therapy. We discovered that there are.


[User] Please transcribe this text

[Assistant] Found that there are three genes that are normally turned on in embryos that keep them young.


[User] Please transcribe this text

[Assistant] What are called transcription factors, proteins that bind to DNA and turn on genetic programs.


[User] Please transcribe this text

[Assistant] Yes, so Yamanaka, Shinya Yamanaka from Japan won the Nobel Prize in 2016 for the discovery of five genes, three of which I've just mentioned. There are two others that, uhm, were able to take cells.


[User] Please transcribe this text

[Assistant] An adult cell back to a pluripotent stem cell stage, very like basically age zero and then you could, we do use these cells to build other tissues. They can be turned into nerve cells and muscle, but you don't want to do that in the body. You'll, you'll become the world's.


[User] Please transcribe this text

[Assistant] So we found a combination of three of these genes and leaving out the other two dangerous ones.


[User] Please transcribe this text

[Assistant] Was a perfect way to reset the age of the body without causing cancer. And it worked better than we could even predicted. We put these genes using a virus.


[User] Please transcribe this text

[Assistant] Uh, we hope in a couple of years we'll be testing our first human.


[User] Please transcribe this text

[Assistant] And we're right now, we've done mice, we're now doing non-human primates. So we're getting closer, but in the mice, it was just a stunning result, which is.


[User] Please transcribe this text

[Assistant] We then put the virus in with these three genes, could turn on these three genes, OS and K for short. And four weeks later, those cells, the retinal cells, the nerve cells that go to the brain.


[User] Please transcribe this text

[Assistant] Which was a stunning result. We also showed that the systems that reset the clock, there are enzymes that control DNA methylation called TETs. Without those, we didn't get vision restoration and the clock didn't go back.


[User] Please transcribe this text

[Assistant] So what that tells us is that the clock going backwards is doable. There is a reset switch in the body and that the clock is part of that system.


[User] Please transcribe this text

[Assistant] Yeah, December 2020, we were, uhm, fortunate enough to get the covers issue. It's a dream for any scientist.


[User] Please transcribe this text

[Assistant] And the title that they had on the cover was turning back time and a picture of an eyeball with a clock hand going.


[User] Please transcribe this text

[Assistant] Yeah, that was one of the highlights of my career and what's happened since is there's been a whirlwind of interest in this from scientists around the world.


[User] Please transcribe this text

[Assistant] Investors, there's more than 20 billion with a B, 20 billion dollars being.


[User] Please transcribe this text

[Assistant] Raise to look at this actual phenomenon of aging reset. And a lot of scientists are turning their attention towards understanding how this works.


[User] Please transcribe this text

[Assistant] Uhm, and even mimicking this gene therapy with little molecules, perhaps plant molecules or drugs that are on the market already. So that one day.


[User] Please transcribe this text

[Assistant] Hopefully in the next 5 to 10 years, we could take a pill or rub a cream on our skin. Not just to slow aging, but to truly reset the age of the body.


[User] Please transcribe this text

[Assistant] Well we are, and inhumans I should say, we're trying to go as quickly as we can.


[User] Please transcribe this text

[Assistant] We found that the reset works in other parts of the eye. We can restore vision.


[User] Please transcribe this text

[Assistant] In mice that have what's called retinal degeneration.


[User] Please transcribe this text

[Assistant] And we've even built little mini brains. We grow these little organoids out of human skin. We give them Alzheimer's disease. These little brains get dementia.


[User] Please transcribe this text

[Assistant] So this is the beginnings of work that I hope will mean that we can reverse the age of the brain and other tissues.


[User] Please transcribe this text

[Assistant] And diseases of old age like Alzheimer's, heart disease, even cancer will go away.


[User] Please transcribe this text

[Assistant] That's right. We built the system in the virus so we could turn it on with an antibiotic, doxycycline, and the patients that we treat.


[User] Please transcribe this text

[Assistant] Uh, if we treat them, we'll take a course of antibiotics to turn on the reprogramming. So we can turn it on for say four to eight weeks. We can measure their vision when they get their vision back again, they stop the antibiotics. Then they age out again, maybe another decade.


[User] Please transcribe this text

[Assistant] And then all they get in the mail is another course of antibiotics to restore their vision again.


[User] Please transcribe this text

[Assistant] Yeah, so he's in California and he, uh, used three treatments. Uh, it's called the TRIM type trial and it included metformin, growth hormone, and DHEA, another hormone. And so growth hormone will rebuild tissues.


[User] Please transcribe this text

[Assistant] Uh, and that gives a response in the body that the times are good, but he also counteracted that with adversity memetics.


[User] Please transcribe this text

[Assistant] The metformin and the DHEA prevented glucose spikes and type 2 diabetes.


[User] Please transcribe this text

[Assistant] And what he showed after a year of this treatment was that the epigenetic clock measured by Horvath, remember this is the DNA methylation patterns, uh, reset in a way that was calculated to take their blood biomarkers back, the blood clock back two and a half years on average. Now that doesn't seem like a lot.


[User] Please transcribe this text

[Assistant] Yeah, and at first I said two and a half years, come on, that's not much. But then I realized if you do that every year or even every two years, you're immortal. And that's when things get really interesting. But we don't know is are these treatments just changing the blood clock or are they changing the whole body? So we need to measure other things.


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[Assistant] Including skin clocks, uhm, and, and blood biomarkers to really know if this is a true aging reset.


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[Assistant] Often when these publications come out, we scientists know a lot more than we're telling people.


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[Assistant] And what he told me, which I'll share with, with all the audience today is it works multiple times. So he's now getting people to go back five.


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[Assistant] And there are some reports of people going back 10 years in their blood's biological age.


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[Assistant] Yeah, we don't know. This is new territory. And I think that's a really important point is we don't know the dangers of resetting the age.


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[Assistant] We believe that it's safe so far. There's been no indication of any downside, but one of the big.


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[Assistant] Worry is if you go back too far in age, you can stimulate cancer cells. So that's another thing to watch out for.


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[Assistant] But I'm, I'm an optimist. I'm optimistic that if the body becomes younger, it'll surveil the body and kill the cancer cells.


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[Assistant] Uhm, which is one of the problems as we get older and what tumors develop is that our body, body's immune system doesn't kill those cancer cells.


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[Assistant] But we don't have, you know, obviously we have a lot of work to do. We're not saying go out and try gene therapy today.


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[Assistant] We could do that theoretically, but definitely don't. We don't know all the risks. And particularly with gene therapy, it can be irreversible. So this is something, don't try this at home.


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[Assistant] Right, uhm, and there can be other side effects as well from gene therapy including immune responses to those viruses.


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[Assistant] One word about those viruses is that it's still early days on drug, on gene delivery.


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[Assistant] Even in, even humans, it's a struggle for diseases that want to be treated holistically. But there are advances and a number of new companies that have sprung up that allow these viruses to infect the body more evenly.


[User] Please transcribe this text

[Assistant] And when that happens, I think we will be able to make mice that can live a decade or two.


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[Assistant] Well, I do even when we talk about extending lifespan by five years, people wonder what are we going to do with all these people? Uh, and the good news is if you do the calculations, first of all, most,


[User] Please transcribe this text

[Assistant] Wealth, health, these all lead to people making decisions that I don't.


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[Assistant] I don't need to have three, five, 10 kids. And this is increasingly happening in South America and in Africa as well. And the prediction is that humanity will peak at about 10 billion, maybe 11 and start to come down again. And that's going to be when these changes actually happen to humanity that people will live longer.


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[Assistant] And there will not be an excess of people. It's not that we'll be overcrowded. That's clear from the math. The other concern people have is what about all the resources and clearly we need to


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[Assistant] Figure out ways to preserve the planet, preserve the environment and not


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[Assistant] We'll allow people to be much more productive and less costly.


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[Assistant] To the economy. Right now we throw away 17% of our GDP in the US on healthcare. Well, we don't throw it away, but a lot of that is used in the last few years of life, which we can probably fix with this technology. We've calculated that if we could extend lifespan by just one year using Metformin as an example, which probably could work better than that.


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[Assistant] The value to the US economy in the long run is $86 trillion.


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[Assistant] And if you do it for 10 years, it's 365 trillion. We just published this in the journal, Nature Aging.


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[Assistant] That is money that can be put towards other problems, improving education, helping to combat climate change among other things, making the world much more efficient and less wasteful.


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[Assistant] For sure. But the, the sums are astronomical. Already we've got more money being put into reprogramming and edge.


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[Assistant] Correction of genetic reprogramming than ever in any other time in medical history. This is a, a true.


[User] Please transcribe this text

[Assistant] Historical event that we're experiencing here. It's one of the reasons we wanted to do this podcast is to bring people along as, as these amazing changes happen. Uh, but, but also the sums of money that we'll be saving are also unprecedented. $360 trillion just in the U S that's money that, you know, you, even if some is wasted, there's going to be a lot to use for good purposes. But I think what we want to do is educate Congress people that when this money comes, it's used for the right purposes.


[User] Please transcribe this text

[Assistant] Right. And not everybody starts out life with a career that they want or they don't have the opportunity. And so with a longer life, there should be multiple opportunities to change careers and do things that


[User] Please transcribe this text

[Assistant] This would, this would be two or three years paid time off to change careers.


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[Assistant] Yeah, as lives get longer and more productive and healthy there should be multiple opportunities to change and do.


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[Assistant] Ultimately what people have always wanted to do. My father is a good example. He's now 82. He left work. His main career.


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[Assistant] In his late 60s, 67, and he thought he was going to die in 10 years from then. It wasn't going to be very pretty.


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[Assistant] He's now 82. He's as healthy as he ever was. He's stronger than me. He started a new career in his seventies. This is the kind of life that I want for everybody.


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[Assistant] In a healthy way contributing to society educating the community, educating our kids.


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[Assistant] Our grandkids, even our great grandkids, with all the wisdom that we accumulate over our lifetimes, it's a huge waste when somebody 80, 90 or 100 dies.


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[Assistant] Well, it's important. Most people who are over the age of 40 or 50 have taken care of a grandparent or a parent who's gotten sick.


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[Assistant] It's a huge burden on everybody and it's not just bad for the person who's dying. It's bad for the family. It's costly, time consuming and emotionally draining to say the least. What we're talking about is.


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[Assistant] Take responsibility for yourself, but also do it for your kids and your grandkids sake.


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[Assistant] No, it's not just simple as take two pills and call me in the morning kind of stuff or call me in the next decade. It is hard work.


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[Assistant] You don't get anything for free. You can't just yet pop a pill and go back 20, 30 years, though maybe in the future we will.


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[Assistant] But for now, the best recipe for long life, greater health and ensure that you make it past 80, 90, maybe even into your hundreds is to do the right things. There's eat the right way. Okay. Eat the right kind of diets. Don't eat as often. Have some period of fasting.


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[Assistant] Get some type of exercise, even better do multiple different types of exercise.


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[Assistant] Stress your body out a little bit. Give it some hormesis. These are adversity memetics. So a bit of cold, bit of heat, those kinds of things.


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[Assistant] The other thing we talked about is some supplements and these new technologies we've talked about today, the monitoring and other things that will actually allow us to live longer. And you might say, well, do I care about living longer? Well, absolutely you should. Why? Because the longer you live, the longer you will live. Right now, if we live an extra year,


[User] Please transcribe this text

[Assistant] We get another three months of life because these technologies are going so fast.


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[Assistant] We'll have another six months of life every year we live. And eventually,


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[Assistant] Another year for every year we live. And that's when things get super interesting.


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[Assistant] Yeah, we've been really lucky. We've got a great team here that we want to thank, you and I.


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[Assistant] One is the researchers, so that a lot of the facts here that have come out of the scientific literature were brought to us by Sarah Ryan and Edith Johnson. They've been awesome. Thanks guys. Also want to thank our producer.


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[Assistant] We got Rob Moore and his assistant producer Jack Jamieson.


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[Assistant] Yeah, hopefully that we'll have a great reception. People can leave five stars on Apple podcasts and tell us if they like it.


[User] Please transcribe this text

[Assistant] Uh, but, but seriously, we're, we're paying attention whether we should do another series or not. We'll, we'll decide based on the reaction. Hopefully people love what we do. They want a deeper dive. They want to know more about fertility, even sexual performance we could jump into.


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[Assistant] And, and we're, there are a lot that we haven't thought of, I'm sure. And our viewers can tell us what they want to hear about. So we'll pay attention to the suggestions. And if there are enough people interested in a topic.


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[Assistant] We'll dive into the scientific literature that's, that's inaccessible to most people and bring those in a factual way and hopefully.


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[Assistant] In a way that is digestible and easy to understand but also entertaining.


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[Assistant] Most importantly, what we wanna do here, and hopefully we've done this in the last eight episodes here, is to give people an idea of what's possible. That their longevity


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[Assistant] Long-term longevity and their daily wellness and performance.


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[Assistant] Is truly in their own hands, even with today's knowledge and technology.


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[Assistant] And just around the corner, we're gonna have things that we can barely dream of.


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[Assistant] Exactly, we can do some deep dives into various topics. It can be about blood glucose and monitoring. It could be about


[User] Please transcribe this text

[Assistant] Fertility and women, we've got lots to cover if we do another set of eight episodes, which we hope we'll do.


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[Assistant] And depending on the feedback from people, if it's really positive, we hope that it will be.


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[Assistant] Yeah. Mr. Park City, Utah. Okay. Sounds good to me. We'll have to ask our boy, Wanda Robb, the producer, but I would love to do that.


[User] Please transcribe this text

[Assistant] Thanks so much for joining us in this first season of the Lifespan Podcast.


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[Assistant] Subscribe on YouTube, Apple Podcasts and Spotify.


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[Assistant] And on Apple, you have the opportunity to leave up to a five star review.


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[Assistant] Also, please check out the sponsors that we mentioned at the start of the episode. That's probably the best way to support the show.


[User] Please transcribe this text

[Assistant] But something you should focus on daily to feel better each day and be healthier for longer. Maybe we'll see you next time.


[User] Please transcribe this text

[Assistant] I've been lost a couple times over the last two days, but I navigated my way here pretty good today, so.


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[Assistant] So, you know, I was born and raised, uh, in Chicago on the south side and grew up playing basketball coming from a...


[User] Please transcribe this text

[Assistant] Pretty big basketball family in the Chicagoland area.


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[Assistant] Uhm, went to Mount Carmel High School, went to King High School, uh, lastly, which was a very, you know, notable, prominent high school, uh, attended Eastern Illinois University, uh, graduated from there.


[User] Please transcribe this text

[Assistant] I played overseas for a little bit and decided to come back and get into coaching. I've always had a passion for it. Both my parents are educators. My dad was a long time coach. My uncles were long time coaches. One of them coached a lot of years in division one. So I had a passion for it. Grew up in it. My mom is a long time educator.


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[Assistant] You know, I just looked at coaching as a, as, as another form of education. And so, uh,


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[Assistant] Got in it at a young age, was an assistant coach at a junior college with my dad, and then eventually became the head coach, uh, there for a couple years.


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[Assistant] I was fortunate to get opportunity back at my alma mater at Eastern Illinois and started there and kind of worked my way up from there. Was at Loyola, was fortunate to be at Loyola during a time where Coach Moser was building a program there that was really at the bottom at that time.


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[Assistant] We, we, we tried to build a culture and establish a culture there and was fortunate enough to go to a Final Four with some of those young guys we recruited, uh, early on.


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[Assistant] From there, uh, you know, forged my path, went to Missouri and...


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[Assistant] You know, ended up at Northwestern, uh, with Coach Collins and got the chance to coach you was, that was awesome and watching you grow, uh, from the time you walked in until, you know, until you became a junior there. And so, but learned a lot from Coach Collins. Uh, again, uh, had to, at that point, and I know you remember this, Ryan,


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[Assistant] Trying to establish a different culture because they were coming off an NCAA tournament a couple years before, but it kind of restarted there. And so had to establish a culture, again, based with a lot of young, young guys. And, um, so that was awesome going through that process. It's not always awesome when you kind of going through some of those dark days and then when you lose them.


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[Assistant] Just watching those, uh, student athletes grow and, and watching and learning from coach Collins on, you know, how to build it again. And it was awesome to look back and see this past year.


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[Assistant] A lot of those same young guys that came in with us, uh, Ryan, you know, make their second NCAA tournament ever in school history.


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[Assistant] Rejoin Coach Moser back at Oklahoma once he took the job after his Sweet 16 appearance at Loyola. And, uh, it was kind of, again, starting the same process there as I've been through a lot in my career just, just building. And so, uhm, it's been, it's been an amazing journey. I've been blessed.


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[Assistant] Uhm, you know, when I look back on my, on my path, uh, I've been fortunate and blessed and I'm just, you know, grateful to, to be sitting here with you in this room today. Yeah, absolutely.


[User] Please transcribe this text

[Assistant] You know, a couple things, uh, one, I was nervous. Obviously coach, uh, you know, coach wanted me to get to Chicago, so I was nervous. It's always a little...


[User] Please transcribe this text

[Assistant] You know, butterflies in your stomach, you know, whenever you're the new guy. Uh, I joked about that a couple of times over the weekend. Being a new guy is a little bit different. I hadn't been a new guy in a while, but you know, for me it was surreal, uh, joining a, uh, a historic, um, great program, special program like Duke, but also the first time joining that program.


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[Assistant] In the city I love, in the city I care so much about, with family there in Chicago, uhm, it couldn't have been a better, better, uh, situation for me. I was telling my wife throughout the weekend and it just felt like a dream, so.


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[Assistant] That's the first thing. Uh, the second thing, you know, with the guys, a lot of the guys that I didn't know as we went through a lot of those informative meetings, uh, just the level of, uh, the level of, uh, engagement.


[User] Please transcribe this text

[Assistant] Uh, from the players, uh, from such young players in some of those meetings that a lot of, you know, places I've been were maybe guys would have thought I was a little boring and.


[User] Please transcribe this text

[Assistant] Some of the questions, uh, they were asking, um, the, the, the speakers, I was, uh, I was really, really, uh, taken aback by how well averse they were, how, how engaged they were. So, you know, that was, that was something that really stood out to me, uh, along the trip.


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[Assistant] As uh, as coach did. So we played for the same AAU program. Uh, so obviously I followed his career from the time he was in high school. We have so many different people in common because we played for the same program.


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[Assistant] And, you know, just followed him closely. Really got to know him during my time at Northwestern. Uh, obviously with Coach Collins, we had so many people in common through that Northwestern, uh, tie. And we, we just started to talk and develop a relationship, got to know him even more. Uh, my first year at Oklahoma, uh, we, we were able to get Jordan Goldwire.


[User] Please transcribe this text

[Assistant] Uh, through the transfer portal in Jordan was a grad transfer. So I dealt with coach a lot doing that process as he was helping me a little bit and talking to Jordan and me and me and coach were talking very often and then through that year.


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[Assistant] As Jordan played for us, you know, when different things came up, me and coach would speak. So we just really started to develop a relationship over those years. And so even before he became the head coach here, I was actually, it was funny. I was looking for a number or name yesterday last night and I was looking back in my text.


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[Assistant] And just seeing those texts back with coach, uhm, back with around the time Jordan was grad transfer and I read him and thought it was pretty funny because it was well before I think he thought or even I thought that he would be the head, the next head coach. So, uhm, so we, we just really, you know, established that relationship and again,


[User] Please transcribe this text

[Assistant] Coming from Chicago, we, we have a, we, we have a bond with a lot of the things that we've been through, a lot of the teams, a lot of the things we've played, places we've played. So, uh, it's been, it's been great to get to know them, uh, even more.


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[Assistant] I know it's probably annoying to a lot of people that's not from Chicago. I say it all the time, but the pride we take in our city, in our basketball tradition, I know people are probably like, oh these Chicago guys, here they go again. But no, we do, we take a lot of pride in that.


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[Assistant] You know what, when I think about it, uhm,


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[Assistant] Obviously, I haven't thought about this much, but if I did, you know, for me, Isaiah Thomas would definitely have to be in there and Mark Aguirre.


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[Assistant] I feel horrible because I know I'm leaving off some really good players on the spot. I'm gonna get some calls tonight about this. Uh, for me, uh,


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[Assistant] High school, especially. You know what? I'm sorry. Dwayne Wade and Derrick Rose. Okay. Derrick Rose.


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[Assistant] And Twon Walker, I apologize, I went to high school because of Twon, so, but Twon would be right there for me too, but those guys, you know, when you think about their pro careers with D Wade and Derrick and Isaiah and Mark, uh, you know, it's great, great players, but it's a lot of great players.


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[Assistant] The reason, a lot of the reason it came down when I left Northwestern, uh,


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[Assistant] It wasn't something necessarily that I wanted to do, at the time.


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[Assistant] But, but Coach, uh, Moser had been so instrumental in my, in my career at such a young age, um, at such a young, uh, uh, turn for me in the profession.


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[Assistant] And he, and he did so much for me during those times.


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[Assistant] That when he was going to restart and rebuild a program at Oklahoma, I felt like I needed to be there with coach because you know what he had done for me during that time of my career. And so again, loyalty is huge with me.


[User] Please transcribe this text

[Assistant] So when me and coach, and you know, what's interesting about me and coach Shire, uhm,


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[Assistant] We talk, we had talked so much over the years that


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[Assistant] It wasn't like this entire process where we were talking everyday about the job. We had already


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[Assistant] Talk so much over the years about different things, about basketball, about recruiting, about life, uhm, that when it came, when this opportunity presented itself, it wasn't like this two week long interview process where we talked all the time about it, and so uhm,


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[Assistant] You know, when, when he had told me that, that he was interested in talking to me about the spot, uh, one, I was, I was grateful and appreciative and, and two, obviously, uh, my stomach had knots in it because, you know, at Oklahoma, we hadn't quite


[User] Please transcribe this text

[Assistant] Uh, uh, got it to where we wanted to get it to when we walked in, uh, the, the program and, and, and, you know, did it kind of like we wanted to do it at Loyola. We hadn't got it there yet. So that was, that was really hard for me in terms of, uh, talking to coach knowing that we hadn't.


[User] Please transcribe this text

[Assistant] We hadn't got to where he wanted to get to with the vision of the program.


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[Assistant] Uh, but at the same time, uh, me and coach Shire had developed such a good relationship. I really got to, got to know him. I really liked him. I really respected him and I saw his vision as well. And so I just thought this was a situation that gave me a opportunity to come here and.


[User] Please transcribe this text

[Assistant] And really continue to help, you know, build on what's already been put in place here, uh, but do it with Coach Shire.


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[Assistant] You know what, Ryus? He didn't have to do, you know, much, uh, getting me excited about this opportunity. Obviously, this opportunity speaks for itself. Uhm, but again, my respect level for him over the years and getting to know him.


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[Assistant] And getting to know, I think he's such a brilliant basketball mind.


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[Assistant] Uhm, and I thought, you know, I'm big on learning.


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[Assistant] No matter how old, no matter how many years, uh, I've been in a business. I think you know, people should be everlasting learners. And so I looked at it as another situation just after talking to Coach Shire that I can come here and I can also learn. Not only can I contribute and help, but it was another situation, another step.


[User] Please transcribe this text

[Assistant] for me to continue learning just about everything. And so, uhm, what got me excited was the opportunity to come and even learn more and even grow as a coach here, so.


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[Assistant] Obviously it's a little bit of nerves that come with that, but nothing uhm, you know, nothing not feel pressure or anything like that.


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[Assistant] Uhm, that, that, you know, it really stuck out to me. I told, I told my wife this. When we were at McDonald's, this is when I knew I was in kind of a different place. We were at McDonald's and the CEO asked,


[User] Please transcribe this text

[Assistant] Crap. So, so now, you know, like, it's not too many playstaffs that I've been on where I've been the worst player on the staff. So this is gonna be a little bit.


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[Assistant] For me, which is, which is hilarious. So, uh, I'm sure a lot of the guys that I've worked with that's used to me talking smack probably gonna re watch this and be like, what is he talking about? Cause I talk so much smack about basketball. I've been very quiet here when it came up to basketball conversations to say the least. So, uh, but I'm, I'm humble.


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[Assistant] Uhm, that's again, I can't say it enough. I have so much appreciation and gratitude for coach, uh, even like you said, you know, taking a, taking a chance on hiring me, uh, and, and where, where it's been guys that normally has played here that, that had, that have held these positions. Yeah.


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[Assistant] You know, I, I tell you this, uhm, right, I, I love, I'm, I'm honored to be known as a, as a good recruiter, uhm, you know, but not really.


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[Assistant] I think overall I'm aiming to be a really good, just overall coach. And that entails recruiting. We all know how important recruiting is in that aspect.


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[Assistant] Uhm, you know, recruiting his relationships. And, and I, I,


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[Assistant] So I pride myself on genuine relationships. That's helped me in recruiting. Uhm, you know, my relationships across the country.


[User] Please transcribe this text

[Assistant] Uhm, are not, you know, are not just uhm, you know, what, what can you do for me? You know, I have


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[Assistant] I have long lasting, serious, deep relationships, uh, with a lot of people that's in turn been able to help me in recruiting. So my strategy with that, uh, won't change. Now obviously who you target, you know, will change being here at Duke, but it's a lot of the same


[User] Please transcribe this text

[Assistant] You know, players that I've dealt with over the course of my years in the business, just now we're recruiting, uh, different guys. And so, um, I'm looking forward to that. Uh, I'm excited about that.


[User] Please transcribe this text

[Assistant] Uhm, you know, I'm a basketball junkie, so I know every player in the country. I keep up with it night in, night out. So I am very excited about it. But again, you know, recruiting is just relationships.


[User] Please transcribe this text

[Assistant] And if you ask, you know, kind of, kind of my, my reputation around the country, uhm, people will tell you that I just, I have really, really solid relationships. And so again, I hate using the word recruiter because


[User] Please transcribe this text

[Assistant] I'm not a salesman, right? I'm not, I'm not a salesman. I try to really get to know, you know, everybody involved and whether they, whether they have a player or not, whether it's a kid I'm recruiting or not, uh, taking genuine interest in, in, in that person or that situation is something I truly proud myself a lot on.


[User] Please transcribe this text

[Assistant] Yeah, so it's a, it's a big difference, which is why the transfer portal at a lot of different places.


[User] Please transcribe this text

[Assistant] But here, it's different because now you can recruit the best of the best. And, you know, with those top 10, top 15 prospects like a Derek Lively, like a Derek Whitehead that you watch, they just have some things that


[User] Please transcribe this text

[Assistant] You know, are going to translate some things that if you've been doing it long enough, you know, the length, the size, the athleticism, uh, the skill level. Um, and then a lot of it too, uh, which goes into the recruiting is getting to know the intangibles and what the players, you know, made of inside. And so if they have all those translatable, um, athletic and skill, uh, abilities, but they also have,


[User] Please transcribe this text

[Assistant] Um, a lot of places have chosen to go to transfer route because it's easier to evaluate older guys that's already played at the level. Uh, but this is, this is, this, this, this is different here.


[User] Please transcribe this text

[Assistant] I'm one of those guys when it comes to everything in life, I believe in you gotta continue to evolve and you gotta stay fluid.


[User] Please transcribe this text

[Assistant] You know, whether you like it or not, whether you agree with NIL or not or agree with the Transfer Portal or not, I think those conversations don't even matter. They're here, it's real, and I think if you either adjust and evolve,


[User] Please transcribe this text

[Assistant] Or you do something different. And so I haven't thought much, you know, when it, when it started to happen, right? I just kind of went with it and you have to figure it out. And because if you don't figure it out, you're going to get left behind. And so, um, I love.


[User] Please transcribe this text

[Assistant] You know, we, I love the challenge of trying to figure it out. Uhm, that I, you know, I pride myself on.


[User] Please transcribe this text

[Assistant] Taking on challenges. I know, you know, this again, Duke is a little different. I've been in some different situations that, you know, at Oklahoma, you know, we had to really start from ground up in terms of NIL, in terms of a lot of things. And it was a challenge.


[User] Please transcribe this text

[Assistant] And so, but, but, you know, I don't, I don't like running from challenges. It was, it was, it's pretty fun to me kind of navigating and going through it. Now some of that again is the places I've been, my background, starting at Loyola from ground up, starting at Northwestern, starting all over again, trying to build it. Those are things that I love to do. I love those challenges. And so, um,


[User] Please transcribe this text

[Assistant] It, it, you know, I think we're starting to, we're going to get out the, the COVID window here. So I think the trans, I think high school, the one thing I don't like about it is that I think a lot of high school players, uh, that's not those top guys are kind of falling, uh, under the radar and kind of falling, you know, falling.


[User] Please transcribe this text

[Assistant] In the cracks a little bit because of the transfer portal, because guys are going so old.


[User] Please transcribe this text

[Assistant] Seven, eight years ago would have been division one players, but now have no scholarships. And so I, I feel, I feel bad. I feel, uh, some empathy for those, those families and those kids. And I think we'll start to transition out of that here soon over the next year or so.


[User] Please transcribe this text

[Assistant] A little bit of a recruiting base, uh, you know, I would


[User] Please transcribe this text

[Assistant] I dabbled in the southeast and recruited the southeast before, recruited the east coast as you know, uh, before, but being here now I can really zero in on those areas, uh, at Oklahoma.


[User] Please transcribe this text

[Assistant] Even though, again, with my relationships, I was able to go do it, but it was a little bit harder to convince a kid from this region to come all the way, you know, to the Southwest, pretty much, in Oklahoma. So, uh, strategy-wise, being in the, in the ACC and being on the East Coast, I'll zero in a little more on some of my relationships in this area.


[User] Please transcribe this text

[Assistant] Uh, well one thing I've learned from being in a lot of different conferences, like you said, I've been thinking in...


[User] Please transcribe this text

[Assistant] I've learned not to have an opinion going into a league before you actually play in that league. Okay. So when I was in the Big Ten, I