(S (S (NP (BASENP (NN Insulin)) (CC and) (BASENP (NN IGF) (NN I))) (VP (VBD were) (VP (ADVP (RB significantly)) (VP (VP (VBN reduced) (PP (IN in) (NP (NP (NP (BASENP (DT the) (JJ frontal) (NN cortex)) (COMMA ,) (BASENP (NN hippocampus))) (CC and) (BASENP (NN hypothalamus))) (PRN (COLON --) (NP (BASENP (DT all) (NNS areas)) (VP (VBN affected) (PP (IN by) (BASENP (NNP Alzheimer) (POS 's))))) (COLON --))))) (SBAR (IN while) (PP (ADVP (RB not)) (PP (IN in) (NP (BASENP (DT the) (NN cerebellum)) (COMMA ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (ADVP (RB generally)) (VP (ADVP (RB not)) (VP (VBN affected) (PP (IN by) (BASENP (NNP Alzheimer) (POS 's))))))))))))))))) (PERIOD .))