The patient was a 47-year-old female, smoker (31 pack-years), employed as a maid, presenting as not seriously ill. The patient resides in the same household as her husband and was vaccinated against TB as a child. She visited the hospital for the purpose of undergoing a TB contact investigation. No reported pulmonary complaints, apart from a long-standing cough in the mornings. She was afebrile, no reported weight loss, no perspiration. The TST was positive with an induration of +16 mm; HIV test results were negative. A chest X-ray showed infiltrates in the upper right and middle fields on both right and left sides. Sputum tests were repeatedly smear-negative, but culture and Bactec MGIT 960 tests were positive. Genome testing demonstrated a positive finding of the MTB gene. Sensitivity to first-line AT was preserved; the patient started AT treatment with the same combination used for her husband (an initial phase lasting 2 months, and a follow-on phase lasting 4 months).