A 67-year-old female presented with dysphagia and loss of weight. There was no lymphadenopathy. She denied any history of previous tuberculosis. On palpation, abdomen was soft and nontender without organomegaly. Ultrasound of the abdomen and computed tomography (CT) showed revealed diffuse thickening of the stomach. Additionally, specks of calcification were noted in the gastric wall on CT. Gastric endoscopy was normal and endoscopic biopsy was negative for malignancy. With suspicion of gastric lymphoma, she was subjected to [18F] fluoro-deoxy-glucose (FDG) positron emission tomography (PET). Whole body contrast-enhanced PET/CT was performed 1 hour after intravenous injection of 10 mCi of F-18 FDG. It showed [Figure 1] diffusely thickened gastric wall with few specks of calcification with intense FDG uptake in the thickened gastric wall (SUVmax 8.3). No significant lymphadenopathy was noted. No abnormal FDG uptake was noted in rest of the organs. The patient was subsequently subjected to laparotomy due to high risk of malignancy. Intraoperatively diffuse thickening of the gastric wall was noted and was inoperable. Biopsy revealed diffuse infiltration of the gastric wall by signet cell adenocarcinoma. The patient is being treated with chemotherapy.