A 31-year-old Hispanic male without significant past medical history or medications prior to admission complained of sudden onset of watery, non-bloody diarrhea associated with mucus and crampy abdominal pain. Three days later the diarrhea became more frequent and the patient started to experience severe, sharp, constant, substernal chest pain associated with nausea and shortness of breath. He was brought to our institution, where an ECG showed ST-segment elevation in the infero-lateral leads, with troponin I level of 8.25 ng/ml and CK-MB level of 44.6 ng/ml. Urgent cardiac catheterization revealed normal coronary arteries and the patient was diagnosed with myopericarditis. The echocardiogram results were within normal limits, with 65%ejection fraction and no evidence of wall motion abnormalities. Initial workup showed an elevated erythrocyte sedimentation rate and C-reactive protein, with normal complete blood count. Stool analysis was positive for occult blood but negative for Clostridium difficile toxin, ova, and parasites on 3 separate stool samples. Further polymerase chain reaction (PCR) workup revealed negative blood and stool cultures and negative serological tests for human immunodeficiency virus, viral hepatitis, Cytomegalovirus, Coxsackie A & B viruses, Echovirus, rubella, mumps, Adenovirus, and Enterovirus. Colonoscopy showed macroscopically congested mucosa in the descending colon, sigmoid colon, and rectum, with scattered petechiae indicative of nonspecific colitis (Figure 1), with normal ascending and transverse colon. Microscopic examination of obtained biopsies revealed evidence of acute mucosal inflammation without ulceration, granulomas, or ischemia, suggestive of nonspecific colitis; acid-fast stains for tuberculosis and immune-stains for cytomegalovirus were negative. The patient was started on Naproxen 250 mg twice daily and chest pain started to improve gradually. Troponin I levels trended up during the first 3 days of hospitalization to a peak of 32.6 ng/ml and then started to trend down. The patient continued to have diarrhea for the first 3 days of hospitalization, followed by spontaneous resolution on day 4 with supportive care. The patient was discharged on Naproxen and was followed up in clinic 2 weeks after discharge, where he was found to be completely asymptomatic, with troponin I level <0.015 ng/ml.