A 68-year-old female was accidentally burned by the gas flame while taking bath on October 10, 2018. She has a history of hypertension, diabetes, and atrial fibrillation. She was transferred from the local hospital to our hospital 46 h after the injury. Tracheotomy was performed on admission and the patient had poor mental response, shortness of breath, and rapid heart rate (160/min). About 80% of the total body surface area (TBSA) was burned, most of them were third-degree burns (Figure 1a). Early burn wound excision was performed and the wounds were temporarily covered with irradiated porcine skin in the first week after injury. Four weeks after the injury, healthy granulation was formed in the wound bed. At this time, we performed a second operation on the patient: autologous stamp-like skin grafting was performed on the upper and lower limbs. In this operation, the results were not satisfactory. The take rate of the skin grafts is only about 50%. In the eighth week after the injury, we performed the third operation. This time we covered the wounds with intermingled skin allografts and autografts (Figure 1b): small skin autografts (0.5 cm x 0.5 cm) + moderate close relative's fresh allografts (1 cm x 1 cm) + large cryopreserved allografts (2 cm x 2 cm). One son of the patient donated his scalp skin, and HIV and hepatitis were excluded preoperatively. A Zimmer electric-driven dermatome set was used to harvest intermediate split-thickness skin allografts from the scalp of the donor (3% TBSA). Then, the burned wounds of the patient were debrided and split-thickness autografts from scalp (2% TBSA) were harvested. The autografts, close relative's fresh allografts, and cryopreserved allografts were cut into different sizes: 0.5 cm x 0.5 cm, 1 cm x 1 cm, and 2 cm x 2 cm, respectively. Then, these intermingled skin grafts were applied to the wound bed. Wound dressings were changed every 2-3 days. There were partial loss of the intermingled grafts and cryopreserved allografts were used to avoid development of newly exposed wounds during wound care. The autografts and fresh allografts expanded and the cryopreserved allografts necrotized and fed off gradually from the edge to the center (Figure 1c). We did not see obvious large area rejection of the fresh allografts. Instead, we found some epithelial layer of the fresh allografts fed off but was re-epithelialized by the autografts very soon. And there was no obvious wound exposure during the entire treatment process. At 3 months after the injury, most of the wounds had healed, leaving about 3% of the TBSA wounds on the back region. At this time, we performed one more operation for the patient: covering the wounds with autologous stamp-like skin grafts. The patient was discharged from the hospital 4 months after the injury. After a year of follow-up, the patient recovered well and regained satisfactory function (Figure 1d-h).