A 52-year-old female patient, who works as a microbiologist, presented with a headache, dizziness, and partial seizures. The onset of symptoms was subacute with gradual progression. She was previously healthy with no past medical or surgical diseases or events, and she was not using any medications. There was no history of blood transfusion, raw milk ingestion, tick bites, or drug abuse. She was married with three children. Physical examination showed normal higher mental functions including speech. Cranial nerve examination was unremarkable apart from mild papilledema. Her tendon reflexes were symmetrical and normal with downgoing toes. The rest of her neurological and systemic examination was normal including vital signs. Basic hematological workup including complete blood count, liver function test, erythrocyte sedimentation rate, C-reactive protein, and connective tissue screen were all unremarkable. Other unremarkable important tests included syphilis serology, HIV test, mammogram, and tumor markers. Serum Brucella melitensis immunoglobulins were both high measuring IgM 12.2 U/ml and IgG 127.4 U/ml (normal range <12 U/ml). Using enzyme-linked immunosorbent assay (ELISA) for cerebrospinal fluid (CSF), Brucella titer was high at 1 : 40 (normal <1 : 20). CSF analysis showed lymphocytic pleocytosis at 63 cells and 88% lymphocytes. Protein was slightly increased, but glucose was normal. Her bacterial culture was negative for both aerobic and anaerobic organisms. Polymerase chain reaction (PCR) for tuberculosis, herpes simplex virus, Epstein-Barr virus, and cytomegalovirus was negative. Both CSF Brucella total antibodies and oligoclonal bands were positive with five well defined gamma restriction bands which were not present in the corresponding serum sample. Magnetic resonance imaging (MRI) of the brain revealed peritrigonal (temporal lobe) deep white matter mass measuring 2.6 x 3.5 cm with surrounding vasogenic edema. There was no restricted diffusion with slightly increased flow at the affected area and normal cerebral blood volume on MR perfusion. Axial and sagittal T1 postgadolinium studies showed minimal enhancement (Figure 1). Diffusion tensor imaging (DTI) revealed a slight reduction in anisotropy and diminished color brightness at the affected region with a normal organization of the fiber tract (Figure 2). MR spectroscopy was suggestive of inflammatory rather than a neoplastic process. The radiological deferential diagnosis included neurosarcoidosis, lymphoma, and low-grade glioma. CSF cytology and flow cytometry were normal. Given the clinical, laboratory, and radiological features, the patient was diagnosed with neurobrucellosis and was started on rifampicin (600 mg/day), doxycycline (100 mg twice a day), and sulfamethoxazole-trimethoprim (960 mg twice a day). The patient's symptoms resolved gradually with concomitant improvement in her MRI images. She was treated for a period of 45 days with clinical but no radiological improvement. CSF analysis was repeated which showed improvement of cell count and protein concentration, but the values were not normalized yet. We instructed the patient to continue using the medications for a minimum of 6 months. The CSF analysis was repeated and completely normalized, and her MRI showed almost complete resolution of the previously noted changes. She remained symptom-free until now (Figure 3).