This was a woman with depression who responded well to a selective serotonin reuptake inhibitor. She was described as cheerful and precise and had been maintaining a diary that she had written in every day for 10 years. She never missed school and was a member of the basketball and softball teams. After graduating from school, she worked in a home for the aged, taking care of the elderly. She was taking piano lessons, learning to perform the Japanese tea ceremony, and enjoyed writing. At the age of 29 years, she became lethargic, depressed, and frequently needed to rest at work. After 2 months, she became withdrawn and could no longer go to work, eat, or bathe herself. She would lie in bed, sobbing and complaining, "I am hopeless and tired". She felt discomfort in her chest and developed irregular menstruation. At the same time, she was diagnosed with cataracts. She visited our hospital at the age of 30 years (7 months after the onset of her symptoms) and was diagnosed with major depressive disorder. MRI findings showed atrophy of the hippocampus and diffuse mild ischemic changes in the cerebral white matter (Figure 1B). The patient's psychomotor slowness and depressed mood improved 3 months after treatment with a selective serotonin reuptake inhibitor (fluvoxamine 12.5 mg/day). Her symptoms resolved and she quickly became cheerful, optimistic, and resumed eating by the age of 31 years.