An 84-year-old female with Child-Pugh class C liver cirrhosis due to hepatitis C presented with a progressive bulging of the anterior chest wall for two weeks. She has not been exposed to soil, gardening, and construction sites. She had not gotten any medical procedures. She denied fevers or chills, productive cough, hemoptysis, changes in weight, or loss of appetite. On examination, there was no dental cavity or ulcer in the oral mucosa. Heart auscultation revealed a regular rate and rhythm without a murmur appreciated. Large subcutaneous mass was on the anterior chest wall (Fig. 1, arrow). No axillary lymphadenopathy was observed. Laboratory data revealed a white blood cell 4600/muL (neutrophil 84%), hemoglobin of 9.9 g/dL, platelet count of 158 x 103/muL. Other bloodwork revealed aspartate aminotransferase of 27 U/L, alanine aminotransferase of 13 U/L, total bilirubin of 0.7 mg/dL, creatinine of 0.5 mg/dL and C-reactive protein of 7.1 mg/dl. Contrast-enhanced computed tomography of the chest demonstrated 7 cm x 7 cm x 5 cm loculated empyema with extension through the chest wall, into the anterior chest wall with rib destruction (Fig. 2). Microscopic appearance of the abscess revealed filamentous branching rods (Fig. 3, A: Gram stain, B: Kinyoun stain). Nocardia farcinica was identified using Matrix-Assisted Laser Desorption Ionization-Time of Flight. The susceptibility of antibiotics to Nocardia farcinica were shown in Table 1. She was successfully treated with trimethoprim/sulfamethoxazole 5 mg per kg per dose 3 times a day and subcutaneous debridement and eventually the empyema necessitans disappeared. But on the 81st day of hospitalization, the patient died of acute respiratory distress syndrome due to aspiration pneumonia. In general, Mycobacterium tuberculosis and Actinomyces spp. are the most common causative pathogens of empyema necessitans, and cases of Nocardia spp. are rarely seen. In general, the risk factor of Nocardia spp. is a preceding history of contaminated water or soil ingestion, and the patient did not respond to beta-lactam. N. farcinica is a clinically aggressive infection, particularly in immunocompromised patients such as lung abscess and brain abscess. Clinicians should pay attention to the possibility of nocardial empyema necessitans in immunocompromised patients.