A 13-year-old previously healthy girl ingested 40 ml of diquat solution in a suicide attempt. The patient developed paroxysmal pain in the upper abdomen and a sore throat, accompanied by vomiting yellow-green stomach contents several times. After 10 h, she was transferred to the intensive care unit of our hospital for further treatment. The vital signs and physical examination showed no significant abnormalities, except slight tenderness in the upper abdomen (Figure 1A). The serum concentration of diquat was 436.2 ug/L, and urine fast screening of diquat was positive (Figure 1B). Many blood tests were abnormal, especially creatinine (93 mumol/L), creatine kinase (1132 u/L), creatine kinase MB isoenzyme (38.6 u/L), and lactate dehydrogenase (312 u/L). Immediately, she accepted the intensive hemoperfusion combined with continuous renal replacement therapy (CRRT) in the model of continuous venovenous hemodiafiltration (CVVHDF), activated carbon adsorption and Sivelestat (Shanghai Huilun Life Science & Technology Co., Ltd., Shanghai, China) for anti-inflammation, and other supportive treatments. In the afternoon, the patient developed dyspnea, irritability, and confusion, suggesting toxic encephalopathy, which was supported by the subsequent screen of computed tomography (CT) (Figure 1C). The patient was given nasal tracheal intubation with ventilator-assisted ventilation in the model of PSIMV (FiO2 45%, f 14 times/min, PC 16 cmH2O, PS 15 cmH2O, PEEP 3 cmH2O). On the 2nd day after admission, the patient developed an elevated body temperature, with a maximum body temperature of 40.1 C, accompanied by a heart rate of 145-179 beats/min. Blood pressure decreased progressively in the range of 55-68/28-35 mmHg, and urine volume also pronouncedly decreased. Procalcitonin 27.81 ng/ml. At the same time, hemodynamic detection using the model of pulse indicator continuous cardiac output (PICCO) showed CI 2.51 L/min/m2, SVRI 2465 dyn.s.m2/cm5, dPmax 1452 mmHg/s, GEDI 292 ml/m2, ITBI 364 ml/m2, ELWI 7 ml/kg, SVI 15 ml/m2, and GEF 23%. The above supported the diagnosis of hypovolemic shock, and anti-shock therapies, including dilatancy and fluid rehydration, were performed under PICCO monitoring immediately. Meanwhile, CRP 25.99 mg/L, IL-6 > 5000.0 ng/L, and PCT 11.72 ng/ml, indicating the diagnosis of systemic inflammatory response syndrome (SIRS). On the 3rd day after admission, the patient developed pain and swelling in both legs. The pronouncedly elevated levels of creatine kinase (the highest was 10941 u/L on the 4th day) and myoglobin (>3000.00 ug/L), which was diagnosed as rhabdomyolysis. After precise fluid rehydration and dilatation, the shock was corrected and urine volume recovered, and the myoenzyme spectrum decreased gradually (Table 1 and Figure 2). On the 5th day after admission, the serum concentration of diquat was cleared to less than 20 ug/L. On the 7th day after admission, the patient recovered well, including the spontaneous respiratory. Meanwhile, the indicators of auxiliary examination gradually stabilized. Three weeks after admission, the patient was discharged from the hospital without obvious discomfort.