A 26-year-old woman consults for parotid hypertrophy and painful bilateral cervical lymph nodes that have been evolving for a week in a febrile environment. Otherwise, she did not have a particular personal or family history or tuberculosis contagion. On the other hand, the patient was asymptomatic on the respiratory level. The clinical examination showed bilateral parotid hypertrophy (Figure 1) and several jugulo-carotid, angulo- mandibular and spinal lymph nodes, the largest of them was almost 3 cm, firm, painful and mobile. However, there was no infectious gateway and the temperature was 38.5 C. Furthermore, biological assessment showed leukopenia at 2358 with neutropenia at 1580, thrombocytopenia at 126, CRP at 4.5 and ESR at 42 mm on the first hour. Nasal endoscopy and chest x-ray were normal. Patient underwent a cervical ultrasound revealing bilateral hypertrophy of the parotid glands, predominant on the right, with poorly limbed plaques and hypoechoic nodular lesions, with intraparotid ganglia and subcutaneous soft tissue thickening in the right parotid without salivary ducts dilatation or clearly visible images of intraductal lithiasis. It is associated with bilateral jugulo-carotid, spinal, sub-mandibular and left supraclavicular adenopathy magma, wich was hypoechoic, roughly oval with largest measurement of 30 x 14 mm. This aspect concludes to bilateral parotitis prevailing on the right associated with multiple inflammatory cervical adenopathy (Figure 2, Figure 3). The patient benefited from an exploratory cervicotomy of a 1.5 cm lymphadenopathy. The histopathological examination shows the presence of numerous necrotic foci rich in clarified cytoplasmic histiocytes. Moreover, no foci of suppuration and no neutrophils or plasma cells are observed. Immunohistochemical stains with the anti-CD68 antibody and the anti-Myelo peroxidase antibody shows a positivity of this cell population. The anti-CD8 antibody remains negative. Moreover, immunohistochemical stains with anti-CD20 antibody and anti-CD5 antibody shows a bitypic distribution of the lymphoid population. The anti-CD10 antibody is strictly positive on follicle. However, the anti-Bcl2 antibody is negative. The anti-Ki67 antibody shows a positivity of more than 50% of the cell population. Thus, the morphological and immunohistochemical appearance first evoking the diagnosis of necrotizing lymphadenitis corresponding either to a Kikushi and Fujimoto disease or lupus. The patient benefited from a dosage of NAAs who returned negative coughing to Kikushi-Fujimoto disease. Therapeutic management was based on oral corticosteroid treatment with rapid clinical and radiological improvement after a few days. In addition, the patient did not present a recurrence after one year of follow up.