A 54-year-old Caucasian woman developed frostbite on her nose after being outside for approximately 3 h in temperatures of -45 C (average). The skin on the nose initially turned pale, followed by desquamation and ulceration that failed to heal (Fig. 1). Six months after the initial frostbite injury, she attended the Astana Oncology Center where an incisional biopsy of the lesion was performed and the histological diagnosis concluded BCC.