A 47-year-old woman presented to the emergency department at our institution in February 2018 with complaints of severe, watery diarrhea associated with blood, causing dizziness and orthostasis. The patient presented with a previous history of bronchiectasis status/postbilateral sequential lung transplantation nearly four years earlier. Of particular note, the patient reported previous bouts of loose stool in her posttransplant course, which she suspected were caused by mycophenolate mofetil, an agent in her immunosuppression regimen. Because the patient thought that the current diarrheal episode was drug-induced, she did not immediately seek medical attention. She reported a slow symptomatic progression, with increasing frequency of stools now associated with blood. Upon arrival, she was hypotensive with low systolic blood pressure (70-80 mmHg), which responded promptly to intravenous fluids. A gastrointestinal work-up that included Clostridium difficile was ordered. The patient was seen by the gastroenterology department and scheduled for an EGD the following morning. Although the patient was started on broad-spectrum antibiotics, the dysentery persisted, prompting admission to the intensive care unit. Six hours later, while being wheeled to the endoscopy suite for EGD at our institution, the laboratory called to report positive V. cholerae culture results from a stool sample (Figure 1). The patient's antibiotics were switched to cover this microorganism. After a single dose of doxycycline, the symptoms of orthostasis and dysentery resolved with a dramatic improvement in overall status. On further investigation, the patient and her husband reported recent seafood consumption at a local restaurant the day prior to presenting to the emergency department. The husband was asymptomatic without signs of infection.