In the last five years of our clinical and surgical activity 3800 cesarean deliveries (CS) have been performed and in 57 cases (1.5%) cesarean deliveries followed a laparoscopic myomectomy. We report the only two cases (3.5%) of uterine rupture that occurred among these 57 CS following laparoscopic myomectomy. The first case was a 31-year-old woman para 0/0/1/0 hospitalized for abdominal pain of sudden onset in the 34th week of gestation. She had undergone laparoscopic multiple myomectomy 2 years earlier, when different types of myoma were excised: one intramural- (IM-) G4 myoma of the posterior wall of the uterus with a mean diameter (diam.) of 5 cm, one IM-G5 left isthmic myoma (diam. 3 cm), one IM-G4 on the fundus (diam. 3 cm), one subserosal- (SS-) G6 of the right wall (diam. 2 cm), and two IM-G4 of the anterior wall of the uterus (diam. 2 cm each one). At the first clinical examination, the findings were deep abdominal pain, dysuria, and a positive Giordano's sign on the right. Her blood pressure was 132/66 mmHg and heart rate 77 beats/min. She was afebrile and not pale. The fetus was alive at cardiotocographic evaluation. There were no palpable uterine contractions, although the patient was groaning with pain. The cervix was closed and there was no evidence of vaginal bleeding. We performed transabdominal 2D ultrasound that showed an alive intrauterine podalic fetus with normal Doppler flowmetry, oligohydramnios, and minimal intraperitoneal fluid; the patient complained of increasing pain on the left side of the abdomen, where ultrasound revealed the presence of a vascularised area whose venous and arterial flow seemed to be in continuity with the umbilical cord and had the same ultrasound characteristics (Figure 1(a)). This vascularised area was located outside the left wall of the uterus and was likely an early sign of uterine rupture (Figure 1(b)). The breach seemed to be 2 cm long on the left wall of the uterus, at the level of one of the previous laparoscopic myomectomy wounds. Continuous cardiotocographic assessment showed a normal fetal heartbeat and the absence of uterine contractions, but the patient continued to complain of abdominal discomfort and started vomiting. An emergency laparotomy was performed. Surgical findings included a breach running horizontally through the entire anterior wall of the uterus (Figure 1(c)), a moderate quantity of hemoperitoneum, while the fetus had turned so that the left shoulder was facing the abdominal cavity. The baby was delivered alive with the placenta, and no emergency procedure was required. The tear was repaired and the hemoperitoneum drained. The patient made satisfactory clinical progress and was discharged home with a healthy baby on the fifth postoperative day; neonatal follow-up was regular.