Patient 2: a 24-year-old female was diagnosed with CBF-AML (inv16, corresponding CBFB-MYH11 fusion gene). Pulmonary tuberculosis had been cured with nine months of four-drug therapy one and a half years ago, but otherwise her medical history was unremarkable. We initiated a course of 7 + 3 combined with a single dose of GO (Table 1). Wide-spread cytarabine-related cutaneous reaction and mucositis and high fever were observed from day 4 onwards. Blood cultures and virus samples remained negative. Because of suspected hyperinflammation (P-ferritin >16500 mug/L, P-IL2R 5509 kU/L), we administered corticosteroid from day 16: fever responded but P-LD was rapidly increasing. P-Hb rose (410 mg/L at highest), and the color of patient's plasma slightly darkened while P-Haptog and P-Bil stayed normal. Hypertension and bradycardia were observed. We did not see any other sign of target-organ damage caused by the toxic reaction. We conducted preemptive TPEs daily on days 20-22. No more TPEs were needed, as P-LD and P-Hb declined after day 22 together with recovering hematopoiesis. CR with low MRD-positivity (CBFB-MYH11 0.02%) was detected in the BM on day 29.