Tuberculous prostatitis has mainly been described in immune-compromised patients. However, it can exceptionally be found as an isolated lesion in immune-competent patients. Tuberculosis involving the prostate gland, apart from being rare, can also mimic cancer of the prostate as well as chronic tuberculosis and therefore requires a high index of suspicion. We report a case of prostatic tuberculosis in a 60-year-old man, healthy and immune-competent patient. After clinical and biological examination, and imaging, prostate cancer was highly suspected. Trans-rectal needle biopsy of the prostate was performed and histological examination showed tuberculosis lesions.