A 20 year old man presented with increasing lethargy and shortness of breath over the past 6 months after visiting parts of Africa. Recently he has lost weight, developed a fever and headache. His chest x-ray and CT scan of chest are as follows:
Under normal circumstances clinical observations such as these would lead the diligent physician to conduct a full clinical assessment and seek to rapidly reverse the cause. At the time of this picture the individual concerned was comfortable, at rest and far from being in extremis. On the morning of May 23, 2007, after having spent 60 days at an elevation higher than 2500m, and having just summited Mount Everest (8848m), four climbers on the Caudwell Xtreme Everest Expedition had arterial blood sampling on their descent.
The mean values for the climbers of PaO2 and PaCO2 were respectively 24.6mmHg/3.28kPa (Normal ref. 75-100mmHg/10-13.3kPa) and 13.3mmHg/1.77kPa (Normal ref. 35-45mmHg/4.67-6.0kPa); the lowest ever documented in humans. These measurements provide a picture of the pattern of and limits to changes in human blood gases in response to hypobaric hypoxia on the earth's highest mountain. In conjunction with initiating factors and the presence of coexisting conditions, hypoxia triggers numerous adaptive and maladaptive systemic responses that remain poorly understood. The authors suggested that an understanding of the limits of adaptation to hypoxia would be relevant to physicians who care for critically ill patients since many of the interventions aimed at restoring or maintaining cellular oxygenation often prove ineffective and may at times be detrimental.
Panel C. Blood pressure is within 'normal' limits, and the pressure overnight is around 15% lower than that during the day (normal nocturnal dipping).
In Panel B, there is no clear diurnal variation in blood pressure meaning that there is absent noctural dipping. Non-dipping can have innocent or pathologic explanations. Perhaps the patient works night shifts, and is asleep during the day, or perhaps the inflation/deflation of the sphygmomanometer cuff caused discomfort and resulted in a very poor night's sleep. Non-dipping has been also associated with obstructive sleep apnoea, diabetes mellitus, obesity, renal failure and other secondary causes of hypertension. In Panel A, the blood pressure is higher overnight than during the day - the so-called 'reverse dipping' pattern, which is again abnormal and in need of investigation. Panel D shows excessive dipping which has been linked with worsening of cardiovascular risk, perhaps due to under-perfusion of vital organs.
Miliary Tuberculosis. The chest x-ray appearances of multiple pulmonary nodules (1-3 mm) is so called due to its similar appearance to 'millet seed'.
Infection (e.g. TB, fungal), metastases (e.g. thyroid, renal, breast, melanoma, pancreatic), and sarcoidosis.
NICE suggests 2 months of treatment with Isoniazid, Rifampicin, Pyrazinamide and Ethambutol, followed by 4 months with Isoniazid and Rifampicin.
Extra-pulmonary sites of infection commonly observed in TB include: lymph nodes, pleura, osteoarticular, skin and liver, although any organs can be involved. There are various central nervous system manifestations, one of which is tuberculomas which could explain this patient's headache.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global disease, with protean manifestations, albeit a disease most commonly associated with the respiratory system. One of the more uncommon forms of pulmonary TB is miliary TB, in which tiny deposits form innumerable nodules between 1-3 mms in the lungs. These are typically uniform in size and diffusely distributed in both lungs. This form of the disease often presents in the sickest patients and represents haematogeneous dissemination for which the prognosis is poor. The name miliary arises from the similarity of the appearances in the lungs to that of millet seed. Millet seed is grown for use in feed for the animal industry as well as a health food for humans.
TB is a truly multi-system disease and can manifest in any organ system, including various central nervous system manifestations, one of which is tuberculomas. Cold abscesses of the neck and chest wall are also a recognised presentation.