A 17-year-old female was diagnosed as pulmonary tuberculosis during a physical examination at the local hospital six months ago. She adopted a therapy of isoniazid, rifampicin, ethambutol and pyrazinamide. During the follow-up, CT scans showed that the original lesions were absorbed gradually while a new 1.4cm x 0.8cm (Figure 6A and B) nodule appeared in the left-superior lobe six months later. The patient denied symptoms of fever, cough, chest pain or weight loss. Laboratory results of ESR, CRP, liver function, tumor markers, GM-test, G-test and autoantibodies related to connective tissue disease were normal. HIV test was negative. IGRAs and tuberculin skin test were positive. CT-guided percutaneous lung biopsy showed tuberculous granuloma. The patient was diagnosed as PR and was continued on the original anti-tuberculosis therapy. The pulmonary mass was reduced to 1.0cm x0.3cm (Figure 6C and D) two months later.