Subject B is a 51-year-old man diagnosed with cardiac laminopathies 12 ago after cardiac catheterization. Six years later, the subject suffered a right-sided embolic stroke, and five years later, he suffered a left-sided embolic stroke, leaving him with a 60% physical disability, including speaking and walking difficulties, similar to his sister. Moreover, he has suffered from severe arrhythmic attacks, which led to a pacemaker surgery to control the heartbeat and a second pacemaker surgery to replace the device's batteries. Subject B takes warfarin for blood clot prevention. A timeline with the relevant points of care episodes is depicted in Figure 2.
Furthermore, their family tree is depicted in Figure 3. Subjects II-1 to II-9 suffered from cardiac malformations, heart attacks, and thrombosis that due to the health care system conditions at the time, could not be distinctly diagnosed. Subjects II-5, III-1, III-3, III-4, IV-15, and IV-16 died from embolic strokes when they were under 60. Subject IV-2 has undergone pacemaker surgery because she showed an atrioventricular block, thrombosis, and arrhythmias. Subject V-10 presents a cardiac valve malformation; however, further testing is required.