A 54-year-old woman, known case of type 2 diabetes mellitus and hypertension, was admitted to the hospital due to fever, severe neck and back pain, as well as nausea and vomiting for 2 weeks. She admitted drinking a small amount of raw milk several weeks before her presentation. She had no signs of meningitis and her neurological examination was normal. A lumbar puncture revealed no bacterial growth with CSF protein level of 0.7 g/L and glucose level of 126 mg/dL (serum glucose level was 268.2 mg/dL). CSF WBC count was <1 cell/mm3 and RBC count was 8 cells/mm3. AFB stain showed no Mycobacteria, and CSF MTB-PCR did not detect M. tuberculosis. Urine culture came back negative for any bacterial growth. However, a blood culture was positive for Brucella spp. In addition, both B. melitensis and B. abortus antibody titers in the serum exceeded 1:1280. An abdominal ultrasound was unremarkable. A transthoracic echocardiography followed by a transesophageal echocardiography were both normal. The patient was immediately started on ceftriaxone 2 g IV every 12 h, streptomycin 1 g intramuscularly (IM) once daily, doxycycline 100 mg orally every 12 h and rifampin 300 mg orally every 8 h daily for a total duration of 6 weeks. Her nausea and vomiting were treated with metoclopramide and ondansetron. Her back pain appeared to be due to disc prolapse rather than Brucella spondylodiscitis as was concluded from the MRI of her cervical and lumbosacral areas. After the patient completed 12 days of therapy, she was discharged on doxycycline 100 mg orally every 12 h and rifampin 300 mg orally every 8 h for 30 days and to continue her parenteral antibiotics as an outpatient. Upon follow up one month later, both Brucella antibody titers declined to 1:1280 in the serum. CRP level was 6.93 mg/L (no level was obtained at baseline). The patient was advised to continue the oral antibiotics for 6 more weeks while streptomycin and ceftriaxone were stopped. Two months later (three months post discharge), CRP level increased to 31 mg/L; nonetheless, antibody titers of B. melitensis and B. abortus declined to 1:640 and 1:320, respectively. As the patient appeared asymptomatic and clinically well, her antibiotics were stopped; though, she was advised to remain under supervision and to return for follow up in case of a potential relapse.