A 59-year-old male, Kurdish in origin, came to our hospital with history of recurrent chronic diarrhoea for last eighteen years. Each episode of diarrhoea was lasting for more than a month and used to get relieved with antibiotics. The patient had also history of pulmonary tuberculosis and recurrent sinopulmonary infections. We evaluated him thoroughly for his chronic diarrhoea. His stool examination showed cyst of Giardia lamblia. His routine blood examination reports were normal. His chest X-ray showed hyperinflated lungs; there was pleural thickening with inhomogeneous opacities suggestive of fibrosis in right upper zone. Ultrasonography of whole abdomen was normal. His contrast-enhanced computerized tomography of chest and abdomen revealed right apical pleural thickening and fibrosis in upper lobe and bronchial wall thickening, paraseptal emphysema, and subcentimetric mediastinal lymphadenopathy (Figure 1). Transbronchial nodal aspiration done was inconclusive. His esophagogastroduodenoscopy showed duodenal polyposis (Figure 2). His total colonoscopy and capsule endoscopy for small bowel were normal. His histopathological examination of duodenal specimen was consistent with features suggestive of inflammatory polyps (Figure 3). His 24-hour urinary protein was within normal limits. Immunological work-up was done. His human immunodeficiency viral serology was nonreactive. CD3, CD4, and CD8 counts were 1208/microlitre, 475/microlitre, and 707/microlitre, respectively. Immunoglobulin levels were IgG < 200 mg/dL (791-1643), IgA < 6 mg/dL (60-436), and IgM < 25 mg/dL (43-279). There was selective deficiency of B-cell (humoral) immunity.