The patient was a 77-year-old female, diagnosed with dry eye at another clinic and treated with sodium hyaluronate ophthalmic solution and diquafosol sodium eye drops for several weeks. She has never worn contact lenses on a regular basis. Because of lack of improvement in her subjective symptoms, she visited Maebashi Red Cross Hospital. Her ocular symptoms were dryness and blurred vision in the right eye. Slit-lamp microscopy with fluorescein staining showed diffuse corneal erosion in the superior cornea and lid wiper staining with hyperemia of the palpebral conjunctiva in the right eye (Figure 1, upper panels). With a diagnosis of LWE, rebamipide eye drops four times daily were prescribed and her other eye drops were discontinued. Fluorescein staining of the cornea and lid margin was remarkably improved (Figure 1, lower panels) and subjective symptoms were reduced in 2 weeks from the start of rebamipide eye drops. Tear film break-up time (TBUT), Schirmer's 1 test, and decimal visual acuity were examined before and 2 weeks after administration of rebamipide (Table 1). For TBUT, corneal staining with fluorescein solution was examined under standard illumination using a slit-lamp microscope with a cobalt blue filter. TBUT was measured three times using a stopwatch as the time from normal blinking to the first appearance of a dry spot in the tear film. Schirmer's 1 test was performed to measure tear volume.