The patient was a 26-year-old female with a chief complaint of epigastric pain since one year previous. Anorexia, heartburn, sensation of postparandial fullness, nausea-vomiting, early satiety and a 10 kg weight loss were among the other signs and symptoms experienced over the previous year. She was prescribed omeprazol and clidinium C with no significant improvement. The patient was admitted to the hospital for further evaluation of worsening symptoms. On physical examination, the vital signs were stable, with no abnormal findings observed in the lungs, heart and extremities. The epigastric area was tender without guarding or detection of a mass. During her hospital course, the patient had two episodes of melena. Laboratory data were remarkable for the following results (Table 1). 
 The patient underwent an endoscopic evaluation. The results indicated a large friable mass with tumoral features in the body, antrum, and prepyloric areas of the stomach which was invaginated into the bulb and the second portion of the duodenum (Figure 1). The endoscopist recommended a barium meal and/or abdominal contrast CT scan. The barium study was remarkable for enlarged gastric folds and varying sizes of multiple filling defects in the distal stomach that continued into the whole parts of the duodenum (Figure 2). In order to relieve the obstruction, surgical interventions were planned. During the surgery, the surgeon observed large polypoid lesions in the stomach that lead to gastroduodenal intussusception. A distal partial gastrectomy and intussusception release was performed. 
 The gross appearance of stomach wall resembled cerebral convolutions and there was diffuse involvement of the stomach (Figure 3). The major histopathologic findings in the gastric specimen included foveolar cell hyperplasia, cystic gland changes, and glands that penetrated into the muscularis mucosa. There were significantly diminished parietal cells noted on histologic examination (Figures 4 A, B). No evidence of malignancy was found in multiple histologic sections. These in addition to other clinical and paraclinical findings were all suggestive for diffuse type Menetrier's disease. 
 Microscopic findings of Menetrier's diease. A_Hyperplastic mucosa with characteristic cystic dilatation of deeper crypts (H&amp;E 40x). B_Glandular penetration to the muscularis mucosa (H&amp;E: 400x).