A 41-year-old haemodynamically unstable diabetic male patient was referred to our hospital after having undergone multiple procedures including placement of a double-J (D-J) stent for a previous ureteric stricture and an emergent tracheal tube insertion. He presented with right-sided pleural effusion and was a known case of tuberculosis receiving modified anti-tubercular therapy, due to altered liver and kidney function. On admission, initial laboratory investigations revealed raised procalcitonin values, and a provisional diagnosis of sepsis and tubercular empyema was made. He was then moved to the ICU and catheterized for monitoring of kidney function. The patient had a fever spike on the eighth day, with urine microscopy revealing pyuria. A urine culture was sent to the laboratory and extensively drug-resistant   Myroides   spp. were isolated which were only sensitive to minocycline. Urine infection subsided by day 7 of minocycline administration and repeat cultures showed no further growth after cessation of treatment.