A 77-year-old male with a history of bladder cancer was treated in early 2018 with intravesical injection of BCG (i.e., a stimulant for a cell-mediated immune response). A few months following his last dose, he presented with severe lower back pain and lumbar radiculopathy. A biopsy of a L1-2 vertebral lesion documented M. bovis (i.e., TB osteomyelitis). Despite anti-TB antibiotics including rifampin, isoniazid, and ethambutol, his symptoms progressed. When the MRI demonstrated progressive degenerative L1-L5 stenosis, he underwent a L1-5 laminectomy. Following this procedure, his radiculopathy and hip pain resolved [Figure 1].