A 2-months-old, 4.3 kg, intact female Vietnamese potbellied pig presented to Iowa State University Food Animal and Camelid Hospital to evaluate pruritus of 2 weeks duration. The owner had noticed pruritus and alopecia, and had administered one dose of ivermectin (0.6 mg/kg, PO). The client noticed no change in clinical condition following treatment. Shortly after the pig was noted to be pruritic, a resident of the home, who had close contact with the pig, developed skin lesions and pruritus, which was diagnosed by the resident's primary care physician as suspect scabies. The pig was examined by a board-certified-large animal internal medicine specialist as well as a board-certified veterinary dermatologist. Parasites obtained from skin scrapings were evaluated by a board-certified parasitologist, and additional material was retained for molecular characterization.