A 35-year-old otherwise healthy male sustained a 2 % TBSA burn to his right lateral thigh when an e-cigarette device in the right back pocket of his pants spontaneously combusted, burning a hole through his pants (Fig. 6). Upon arrival to the emergency department, he was found to have partial- and full-thickness burns to his right thigh (Fig. 7). The patient was treated in the outpatient setting with topical wound care. The patient elected for non-operative treatment and healed in 5 weeks.