Our patient was a 53-year old previously healthy, nonsmoker with no reported unusual recent exposures, male who presented to an outside hospital with severe respiratory distress. He was started on empiric broad-spectrum antibiotics and oseltamivir phosphate (150 mg PO BID, Tamiflu, Genentech, Inc., San Francisco, Calif, USA) and Methylprednisolone (60 mg intravenous, Q6H for 3 days). Initial bacterial blood and respiratory cultures were negative, but had a positive nasal swab for Influenza H1N1. Initial chest X-ray showed severe diffuse pulmonary infiltrates and edema consistent with adult respiratory distress syndrome (ARDS, Figure 1). Five days later, due to failure of maximal mechanical ventilation and worsening hypoxemia with hypercarbia he was placed on percutaneous veno-veno ECMO and transferred to our Institution. Upon arrival, bacterial and fungal blood, urine, and respiratory cultures from a bronchial alveolar lavage were obtained and were negative. Real-time polymerase chain reaction assay was positive for H1N1-2009. Other viral cultures, including HIV-1/-2 and a hepatitis panel, were negative. A transthoracic echocardiogram was unremarkable. Over several days, antibiotic therapy was deescalated, and he completed a 10-day course of oseltamivir.
After 7 days of ECMO support, he was successfully weaned and decannulated. His ventilator requirements slowly improved, and despite an Enterobacter aerogenes ventilator-associated pneumonia that developed post-ECMO decannulation, the remainder of his hospital course was unremarkable. He was discharged for rehabilitation 22 days after ECMO decannulation (hospital day 31).
At followup, 4 months following-discharge, he was doing well, repeat chest X-ray showed no evidence of acute or chronic disease, and pulmonary function testing showed normal spirometry, a mild restrictive ventilatory defect, a mildly impaired diffusing capacity (23.6 ml/min/mmHg, 74% predicted), and a normal 6-minute walk (515 meters, normal: 365 meters). In discussion with the patient, he recalled having been vaccinated against "the flu". Following appropriate release of medical records, it was confirmed that 2 months prior to the onset of symptoms he received 0.5 ml of inactivated trivalent influenza vaccine in the left deltoid (Fluzone, Sanofi-Pasteur Inc., Swiftwater, Pa, USA). Vaccination was provided by a local Pharmacy run vaccination clinic with established policies and procedures conforming to State and Federal regulations regarding the storage and administration of vaccines. No postvaccination problems were reported. 
Influenza H1N1-2009 was a formidable challenge worldwide during 2009 in terms of severity of illness and ease of transmission, particularly in otherwise young and healthy patients. The Australian experience estimated 1.6-2.6 cases per million required ECMO following infection with H1N1. In the 68 patients who required ECMO the mortality was 21%:a rate much greater than expected with recent seasonal Influenza outbreaks. 
Large-scale vaccination efforts were undertaken to minimize the spread and impact of the evolving pandemic. While the immunogenicity of the vaccine has been documented, the incidence of seroconversion is variable. In one study, only 75% of adults seroconverted while another study demonstrated a 95% seroconversation rate within 21 days in those adults who received a single 15 ug dose of a trivalent, unadjuvanted, inactivated, split-virus vaccine. Regardless, given inherent variability in antigenicities and immune responses, with such a large population at risk, even a small percentage of vaccine failure can have a significant epidemiologic impact. Furthermore, considering the virulence of H1N1-2009 the risk of developing catastrophic respiratory failure requiring high-intensity ventilator or even ECMO support is not negligible.