A 54-year-old Caucasian woman was diagnosed at the age of 48 with a BRAF-mutated, stage IIIc (T3b, N1a, M0) melanoma on her left calf. She was treated with interferon alpha in the adjuvant setting, but two years letter an in-transit lesion on her left thigh emerged and was excised. She was then treated with ipilimumab, but treatment was discontinued due to hypophysitis. A year later, she developed a subcutaneous nodule on her chest, the histologic examination of which was consistent with a metastasis. She was treated with nivolumab, at 240 mg every two weeks, but six months later she experienced a grade-3 increase of the liver enzymes [serum glutamic oxaloacetic transaminase (SGOT)/serum glutamic pyruvic transaminase (SGPT)] and nivolumab was permanently discontinued. She was then started with dabrafenib at 150 mg twice a day and trametinib at 2 mg once a day in the adjuvant setting. The patient experienced recurrent panniculitis lesions on both lower limbs and the abdominal wall during the first four months of treatment; nine months after treatment initiation, upon her 3rd imaging assessment of response, several enlarged paratracheal, subcarinal, aortopulmonary window, and hilar lymph nodes were found without any parenchymal lung lesions. No other signs of disease progression were found. The patient underwent a bronchoscopy and an endobronchial ultrasound-guided biopsy (EBUS-TBNA) of one of the subcarinal lymph nodes. The histologic evaluation of the lesions revealed epithelioid non-caseating granulomas without multinucleated giant cells, suggestive of a SLR. Her complete blood count, biochemistry profile, and serum angiotensin-converting enzyme (sACE) levels were within normal limits while an interferon gamma release assay (IGRA) was found to be negative. The patient received no treatment for these lesions and continued treatment with dabrafenib and trametinib without any dose reduction. Eight months later, she is still in complete remission, with no change in the number and/or size of the lymph nodes. Scarce erythema nodosum lesions still come up on her legs but are well-tolerated.