Patient 3:In June 2010, a 45-year-old brother of patient 2 presented with transient right-arm and hand weakness, and numbness with dysarthria for one day. He subsequently developed staring episodes thought to represent seizure activity, headaches, and behavioral changes including inappropriate behavior in public places, disinhibition, and anger outbursts. Brain MRI on a 3.0 T magnet (Fig. 5) revealed multiple cortical and subcortical areas of blood products bilaterally involving the supratentorial cerebral hemispheres. One large lesion in particular affecting the cingulum was thought to contribute to the behavioral issues.