A 31-years-old man who was otherwise healthy presented to the emergency department with high grade fever that persisted for a week but was manageable with acetaminophen (paracetamol). The patient also suffered from headache for three days which he described as being band-like surrounding his head. He reported regular contact with camels and occasional consumption of their raw milk. Three weeks before presentation, he was on vacation in Turkey where he consumed raw dairy products at a rural farm. He was febrile but his physical examination was normal otherwise. Lab investigations revealed a CRP level of 13.5 mg/L and CSF analysis showing a WBC count of 59 cells/mm3 (polymorphonuclear cells of 23% and lymphocytes of 71%), RBC count of 3 cells/mm3, protein level of 0.43 g/L and glucose level of 54 mg/dL (serum glucose was 100 mg/dL). His blood and CSF cultures were negative for Brucella spp. and so were the AFB satin, culture, and MTB-PCR. Nevertheless, his Brucella serum serology revealed an antibody titer of 1:1280 for both, B. melitensis and B. abortus. He was admitted as a case of neurobrucellosis and was started on ceftriaxone 2 g IV every 12 h, amikacin 720 mg (7.5 mg/kg) IV every 12 h, doxycycline 100 mg orally every 12 h and rifampin 900 mg orally once daily. Ten days later, he stared having spikes of fever reaching 40  C, a thorough physical examination and work up were done and they were negative for any potential infection or reason for fever. Thus, antibiotic-induced fever was suspected due to ceftriaxone, thus, it was discontinued despite the overall improvement of the patient's central nervous system symptoms. Ceftriaxone was replaced with ciprofloxacin 400 mg IV every 8 h. As the fever persisted and liver enzymes were noted to increase, rifampin was stopped as well. In less than a week, rifampin was reintroduced. However, 90 min after the dose, the patient experienced shortness of breath, rash, swelling and redness of skin. His reaction was managed immediately with antihistamine and hydrocortisone. This allergic reaction was presumed to be attributed to rifampin; hence, it was stopped and never introduced again. Moreover, the patient also complained of reduced hearing in his right ear which was suspected to be due to an ototoxic effect of amikacin which resulted in its discontinuation. In order to enhance the management of neurobrucellosis, trimethoprim/sulfamethoxazole (TMP/SMX) double strength was started orally; yet, the patient had an episode of vomiting, so it was switched to IV which was well tolerated. Later on, as the patient was being prepared for discharge, IV TMP/SMX was stepped down to the oral formulation again. A lumbar puncture was repeated before discharge and showed an improvement from baseline with WBC count of 4 cells/mm3 (lymphocytes of 86%), RBC count of 9 cells/mm3, 0.33 g/L of protein and 61.2 mg/dL of glucose (serum glucose was not available at this point of time). Repeated antibody titers for B. melitensis and B. abortus were 1:640 and 1:320, respectively. The patient was discharged on doxycycline 100 mg orally every 12 h, ciprofloxacin 750 mg orally every 12 h and TMP/SMX double strength orally every 12 h. In his first outpatient visit one month after discharge, the patient admitted to voluntarily discontinuing TMP/SMX due to severe episodes of vomiting and refused to take it again; however, he continued taking doxycycline and ciprofloxacin which resulted in clinical success (after a total of 18 weeks on doxycycline and 16 weeks on ciprofloxacin).