To elucidate the pathogenesis of V. vulnificus in South Korea, a clinical strain, V. vulnificus FORC_017, was isolated from a 63-year-old woman with the symptom of a hemorrhagic rash after consuming a raw dotted gizzard shad on Jeju Island. The genome was completely sequenced and analyzed using various bioinformatics tools. In addition, comparative genome analysis of the FORC_017 strain and other clinical isolates was performed. The results of this study would provide genomic insights into the main factors associated with food-borne outbreaks and pathogenesis, and is probably useful for further control of this highly virulent pathogen in seafood.