56-year-old male was admitted for evaluation of prolonged abdominal pain and severe weight loss. He has congestive heart failure and no family history of cancer. CT scan revealed pancreatic mass, omental implants and multiple hepatic lesions. CA19-9 was within normal limits (18.5 u/mL). Liver biopsy exhibited poorly differentiated carcinoma, suitable for pancreatic origin. Again, the tumor was MMR-proficient, wild-type sequences of BRCA1/2. Due to low performance status and intermediate cardiac function, the patient started monotherapy with gemcitabine. Meanwhile, NGS panel discovered wildtype KRAS and BRAF c.1799_1801delTGA mutation, likely pathogenic according to ClinVar database. The case was discussed on MTB and the patient was advised to receive BRAF and MEK inhibitors on first sign of disease progression. Close cardiac monitoring was offered. As expected, metastatic progression was recorded and the patient started full dose Dabrafenib and Trametinib. After two weeks of treatment the patient developed severe unilateral interstitial lung disease. He received high dose steroids and all drugs except Dabrafenib were discontinued. The patient has recovered and resumed low dose Trametinib. The tumor was stable (per CT and CA19-9) for 3 months. However, after 3 additional months, just before his next evaluation the patient arrived to the Emergency Department in severe shock (probably septic) and passed away within minutes (post mortem analysis was not done).