A 24-year-old primigravida at 35-week period of gestation (POG) with MDR-TB was admitted in view of severe growth restriction and oligohydramnios. She had past history of pulmonary tuberculosis at the age of 14 years for which she received treatment for 6 months. She had relapse of pulmonary tuberculosis 1 year back and was suspected to have MDR-TB in view of worsening symptoms along with sputum positivity after 6 months of first line treatment. Sputum testing revealed drug resistance for isoniazid and rifampicin. The patient was started on second line antitubercular drugs, that is, ethionamide, cycloserine, levofloxacin, ethambutol, and pyrazinamide, along with injection of kanamycin for six months till sputum conversion. In continuation phase, injection of kanamycin was omitted and the patient continued to use the rest of the drugs. She conceived while on same treatment and was continued on the same drugs after consultation with pulmonologist. Her general physical examination did not reveal any abnormality and HIV and the rest of the routine antenatal investigations were normal. Fetal evaluation revealed severe growth restriction and oligohydramnios at 28 weeks of gestation. Fetal surveillance was continued with biweekly biophysical profile; she was given antenatal steroids and caesarean was performed at 35 weeks in view of breech with growth restriction with severe oligohydramnios. She delivered healthy baby with birth weight of 1.2 kg (standard deviation of less than 2) with Apgar score of 8 and 9 and there were no obvious congenital malformations. Neonatal work-up for tuberculosis revealed normal chest X-ray and Mantoux and gastric aspirate, cerebrospinal fluid analysis, and urine tested for acid fast bacilli were also negative. Placental membrane tested for acid fast bacilli was also negative. Baby was started on breast-feeding and given isoniazid prophylaxis. Infant's evaluations at 3 months were negative for tuberculosis and the baby continued on the same prophylaxis for 6 months.