Case 2: A 54 year old post-menopausal female was referred following the removal of a 4 cm endocervical polyp with final histopathology demonstrating a malignant melanoma with positive margins. Immunostains for S100, HMB-45, and Mart-1 were positive (See Fig. 2). A staging PET/CT scan was negative for metastatic disease, and a pelvic MRI demonstrated a 23 x 22 x 49 mm cervical lesion with concern for parametrial extension. The patient underwent a type-III radical hysterectomy, bilateral salpingooophorectomy and pelvic lymphadenectomy with residual amelanocytic melanoma involving the full thickness of the cervix and extending to the vagina with extensive angiolymphatic invasion. All margins were negative, as were 26 pelvic lymph nodes. Her post operative course was complicated by a small bowel obstruction that resolved with conservative management as well as a pelvic abscess which required percutaneous drainage and antbiotics. A multidisciplinary team recommended high-dose rate brachytherapy given the high-risk features, which was completed 8 weeks after surgery, followed by systemic therapy with ipilimumab. Unfortunately, she was hospitalized for nausea and vomiting post-radiation, and imaging revealed metastatic disease with innumerable new liver and pulmonary metastases that were not present on imaging 6 weeks earlier. She was lost to follow-up and died of disease 2 months later (7 months from initial diagnosis) without receiving systemic therapy.