A 68-year-old Filipino man with history of diabetes and newly diagnosed pulmonary tuberculosis (TB) on rifampin, INH, ethambutol, and pyrazinamide presented to clinic with diffuse skin eruption for past 7-10 days. The patient initially developed a pruritic rash that began on his neck and eventually covered most of his body. The patient reports soreness with swallowing that started 7 days ago but denies any regurgitation. Exam was significant for diffuse, confluent, blanching, erythematous macular rash on face, scalp, upper extremities, including palms and soles, abdomen, buttocks, upper and lower extremities, no bullae formation, and no excoriation. There were moist mucous membranes, lips slightly edematous, dry, cracking, no blistering, and good dentition without abscesses. There was no conjunctival involvement [Figure 1]. The patient was directly admitted form clinic to University Hospital. The patient was seen by both Dermatology and Allergy/Immunology service. All four TB medications were immediately discontinued because of possible suspicion of allergic reaction. Intravenous hydration was started with normal saline at 100 ml/h with electrolytes supplementation. On admission, the laboratory findings were significant for eosinophilia and transaminitis. The patient was started on steroid cream to face twice a day as per recommendations from Dermatology for erythema multiforme. Next day of admission, the patient had worsen eosinophilia and transaminitis. Punch biopsy skin was found to be erythema multiforme. During the hospital course, the patient had desquamation of skin so he was started on steroids and later was discharged on day 10 on TB therapy and 3-week tapering dose of prednisone as well as second-line TB therapy cycloserine and moxifloxacin, as an outpatient recommended by the Pulmonary team. After 2 weeks of follow up as outpatient, there was regression in rashes of the patient and after 1 month the rashes disappeared. The eosinophils normalized on repeat labs [Figure 2].