A 61-year-old woman presented with inflammatory thoracic and back pain. Clinical examination showed a stiffness of the lumbar spine. She had no fever. The CRP and ESR were elevated to 14 mg/L and 83 mm, respectively. Conventional radiography showed a narrowing of the intervertebral discs of D5-D6 and D6-D7. Spine MRI showed spondylodiscitis in D3-D4, D4-D5, D5-D6, D6-D7, and L1-L2 and soft tissue involvement, simulating infectious spondylodiscitis (Figure 3). All infectious investigations were negative: chest X-ray, cytobacteriological urinalysis, tuberculin skin test, test for mycobacterium tuberculosis in sputum and urine, and Wright's serological test. The discovertebral biopsy showed unspecific inflammation. Despite the negativity of the infectious investigation and given MRI findings and the notion of unpasteurized milk consumption, the diagnosis of brucellar spondylodiscitis was first evoked, and treatment with Rifadin and doxycycline was decided upon. After six months of treatment, no clinical improvement was noted. CRP and ESR remained elevated. No bone reconstruction was noticed in the X-rays. So, a second MRI was performed and showed the stabilization of the original lesions and the appearance of a new lesion in L4-L5. A second infectious investigation was performed but was negative. A discovertebral biopsy was indicated and was sterile. The diagnosis of SAPHO was then suspected, and bone scintigraphy was performed showing uptake in the chondrosternal articulations and D4 to D7 vertebrae, supporting the diagnosis of SAPHO (Figure 4). Treatment with NSAIDs associated with brace wearing was indicated. The patient did not respond to four classes of NSAIDs, so the decision was to switch to etanercept with initial clinical and biological improvement and unchanged lesions in MRI after 3 months. The treatment was received for 1 year. The treatment was received for 1 year without any efficiency. A new MRI was then performed showing an inflammatory marrow signal from T1 to T9 complicated by kyphosis at the top of T7 and associated with inflammatory damage at the anterior chest wall, predominantly the right sternoclavicular joint (Figures 5(a)-5(c)). Switch to infliximab was then indicated.