The human tissues analyzed in this study (livers, lungs and kidneys) were obtained from four dengue fatal cases that occurred during a Brazilian outbreak of DENV-3 in 2002 in Rio de Janeiro. All patients died with a clinical diagnosis of severe dengue with infections confirmed by positive serum IgM antibodies. The four negative controls, from both sexes and ranging from 40 to 60 year old, were non-dengue and did not present any other infectious disease. More information about these cases can be found in a previous report of our laboratory. Briefly: