An 18-year-old girl with type 1 diabetes mellitus presented with focal convulsions in September 2012. She was detected to have multiple tuberculomas. Biopsy of one of the lesion grew MTB. She was on second-line ATT since September 2012 as drug-sensitivity testing (DST) of the tuberculous lesion showed resistance to isoniazid (INH), rifampicin (R), pyrazinamide (Z), ethambutol (E), moxifloxacin (Mfx), ofloxacin (Ofx) and ethionamide (Eth). Her cererbrospinal fluid (CSF) examination was normal. She was put on capreomycin, PAS, cycloserine (Cys), clofazimine and linezolid (Lnz) along with carbamazepine and levetiracetam and prednisolone (1 mg/kg/day for 30 days and then tapered off in next 1 month). In February 2013, she had moderate sensorineural hearing loss, and capreomycin was omitted. Her serial magnetic resonance imaging (MRI) brain till August 2013 showed decrease in size and number of the granulomas in the frontal periventricular parenchyma bilaterally, but the left frontoparietal granuloma remained the same. In February 2014, Lnz and Cys were stopped and clarithromycin was added due to tingling and numbness in the right leg. In February 2015, computed tomography (CT) brain still showed presence of left frontal granuloma. In May 2015, her ATT was stopped, as she had completed 2 years 6 months of therapy and was asymptomatic except for persistence of left frontal granuloma. In April 2016 (Figure 1), granulomas remained the same in the frontal parenchyma, while the rest of the lesions had calcified, but the patient remained asymptomatic.