On November 19, 2001, a suspected case of inhalational anthrax in a 94-year-old woman was reported to the Connecticut Department of Public Health (CTDPH). This was the first case of Bacilus anthracis infection reported to the CTDPH since 1968 and the eleventh inhalational anthrax case in the United States since October 4, 2001. The patient's symptoms of fever, fatigue, malaise, dry cough, and shortness of breath began 20 days after the last confirmed inhalational anthrax patient became ill and 36 days after the last known intentionally contaminated letters, addressed to U.S. Senators Thomas Daschle and Patrick Leahy, were postmarked in Trenton, New Jersey (Figure 1).The patient in Connecticut was not in the known categories of intentionally contaminated letter recipients and was not a postal worker or a mailhandler. This report describes the epidemiologic and environmental investigation conducted to determine whether her case was related to the other bioterrorism-related cases; whether she was the only case in Connecticut or a sentinel of a larger outbreak; and the source, place, and time of her exposure. The clinical aspects of the case have been described.