The VZV infection order in this family is shown in Figure 1. A 16-month-old immunocompetent boy (the first patient, Case 1) was brought to the hospital with 2 days of fever and 1 day of rash on October 16, 2020. At the current visit, the boy had respiratory symptoms (cough and wet rales), and his temperature was 41 C. He had rash on his chest (Figure 2A), back (Figure 2B), hip (Figure 2C), and sever blisters on the soles of his feet. He was initially diagnosed and treated as hand-foot-and-mouth disease (HFMD), with semi-annual HFMD outbreak in Wuhu, October. However, RT-PCR assay for enterovirus universal primer, Enterovirus 71 (EV71), and Coxsackie A16 (CoxA16) specific primers were negative. Chest radiography performed at the time of admission to our hospital showed multiple nodules coalescing to form nodular consolidation and infiltrates in both lungs. The tests for anti-VZV IgM and IgG were both negative to the October 17 serum sample (Table 1). Treatment with oral acyclovir at a dose of 100 mg two times a day, the boy's cough resolved on October 23. His serum was taken at the 7-day follow-up visit (October 26), and tested positive for both anti-VZV IgM and IgG (Table 1). The diagnosis of varicella pneumonia was confirmed. His rash completely subsided on November 2 (Figure 2D).