A 62-year-old female patient, who resides in Caracas, Venezuela, and had no previous relevant medical history was seen in January 2019, because of a lower back pain and a sciatica leg pain affecting both lower limbs. The straight leg raise test (Lasegue test) was positive, producing a radiating pain in both extremities. Other physical examinations, including a neurological examination, biochemical and cellular blood examinations, a chest X-ray and an electrocardiogram, were normal. An MRI (Magnetic Resonance Imaging) scan of the lumbar spine showed evidence of a fracture and pseudoarthrosis of L2-L3-L4 and lysis of discs L2-L3 and L3-L4. The patient was hospitalized with a differential diagnosis of infectious spondylodiscitis versus a space-occupying lesion (Fig. 1). A percutaneous transpedicular biopsy of the spine was cultivated on egg-based solid Lowenstein-Jensen and Stonebrink media. On Stonebrink medium, a confluent growth of smooth colonies was observed after 3 weeks of incubation. After 7 weeks of incubation (one week longer than the regular incubation time for cultures in most TB laboratories), dysgonic growth of a few small colonies of acid-fast bacilli were observed in l-J medium. Due to this dysgonic growth on said medium and the appearance of smooth colonies and atypical rough colonies of M. tuberculosis, the laboratory further characterized the Mtb-complex strain for the presence of regions of difference (RD), a molecular technique used to differentiate between the members of the MTBC based on variable regions among the genomes of the MTBC, which are results of insertion-deletion events. This genetic analysis revealed an RD9 and RD4 deletion and the presence of the region RD1, characteristic for a M. bovis strain. Given that M. bovis is naturally resistant to pyrazinamide, the patient was treated with a standard TB treatment replacing pyrazinamide with moxifloxacin. A control MRI scan was performed after six months of treatment and showed a radiological improvement compared to the earlier imaging studies. The patient is now on the waiting list for a bilateral laminectomy of the L3, L4, and L5.