Structure, bioactivity, and cellular localization of myomodulin B: a novel Aplysia peptide.
Important insights into mechanisms by which neuromuscular activity can be modulated have been gained by the study of experimentally advantageous preparations such as the ARC neuromuscular system of Aplysia. Previous studies have indicated that one source of modulatory input to the ARC muscle is its own two motor neurons, B15 and B16. Both of these neurons synthesize multiple peptide cotransmitters in addition to their primary neurotransmitter acetylcholine (ACh). Peptides present in the ARC motor neurons include SCPA, SCPB, buccalin A and B, and myomodulin A. We have now purified a novel neuropeptide, myomodulin B, which is structurally similar to myomodulin A. Myomodulin B is present in two identified Aplysia neurons that contain myomodulin A; the ARC motor neuron B16 and the abdominal neuron L10. Ratios of myomodulin A to myomodulin B are approximately 6:1 in both cells. Like myomodulin A, myomodulin B potentiates ARC neuromuscular activity; it acts postsynaptically, and increases the size and relaxation rate of muscle contractions elicited either by motor neuron stimulation or by direct application of ACh to the ARC. When myomodulin A is applied to the ARC in high doses (e.g., at about 10(-7) M), it decreases the size of motor neuron-elicited muscle contractions. This inhibitory effect is never seen with myomodulin B. Thus, despite the structural similarity between the two myomodulins, there exists what may be an important difference in their bioactivity.


For more on this topic:

368,379 people killed, 306,096 injured and over $2,815,931,000 in economic damages

What's the harm in psychic surgery?

Psychic surgery allegedly allows the practitioner to remove tumors and otherwise heal the body without making an incision. Read more about psychic surgery

Here are 602 people who were harmed by someone not thinking critically.

Andy Kaufman (comedian) Age: 35

Los Angeles, California Died

May 16, 1984 Diagnosed with inoperable cancer, he sought out alternative therapies. He even flew to the Philippines to receive psychic surgery for six weeks. These treatments wasted time he could have spent with his family before he died. Read more & more

Peter Sellers (actor) Age: 54

Dorchester, England Died (untreated heart condition)

July 24, 1980 A heart attack in 1964 had permanently damaged his heart. His doctors were advising bypass surgery, but he delayed it and instead saw psychic surgeons twice a year. He died of a massive heart attack. Read more & more

600 Canadian patients Toronto, Ontario, Canada Defrauded

June 15, 2005 He came to Canada from the Philippines, and patients came to him in a hotel room for healing. He was using psychic surgery (actually a slight of hand trick) to take $135 from each of them. Police arrested him and charged him with fraud. Read more & more


1. Field of the Invention
The present invention relates to an apparatus for manufacturing a seat including an automotive seat, and is particularly concerned with an apparatus for forming a seat, of such integral foaming type wherein a trim cover assembly and a foam base material are foamed together in a die into an integral unit of seat having an outer cover member and a foam cushion member covered integrally therewith.
2. Description of Prior Art
An integral foaming with a trim cover assembly into a certain seat, such as for example, an automotive seat, has been effected in view of easy operation requiring no adhesive, and various kinds of apparatuses therefor have been provided and known. Particularly, let us focus an apparatus having three die members for such integral foaming: As known from the Japanese Patent Laid-Open Publication No. 49-76653, basically the apparatus of this kind includes a lower die member upon which a trim cover assembly is placed, an intermediate die member having a contour similar to the body of seat, which is to be mounted upon the lower die member, wherein the trim cover assembly is retained between the lower and intermediate die members, and an upper die member which is to be mounted upon the opened side of the intermediate die member. Accordingly, a hollow is defined within those three die members, in which a foaming base material is injected and then a foaming is effected therein in order for the trim cover assembly to be integrally foamed with a foamed resultant cushion member.
A typical explanation on this sort of apparatus will be given now by referring to FIGS. 1 through 3.
As shown in FIG. 1, the apparatus comprises an upper die member (3) whose shape conforms to that of the bottom surface of a resulting seat, which is formed at its center area with an injection port (31), through which a foaming base material is to be injected, an intermediate die member (1') which in composed of three separate die pieces (1a') (1b') (1c') although not clearly shown and reference may be made to FIG. 4 from which the designation (1c') being not shown should be assumed as generally corresponding to (1c) for understanding, the die pieces (1a')(1b')(1c') being to be put togther and intended for forming a body of resulting cushion member (5'), and a lower die member (2) upon which is placed a trim cover assembly (4). The trim cover assembly (4) consists essentially of a seating surface portion (4a) and a side wall portion (4b), the seat surface portion (4a) including an outer cover member (41) made of a woven fabric or the like, a foam wadding (42) formed of a slab-type urethane foam material, and a wadding cover (43) of non-woven fabric or the like, and the side wall portion (4b) being a single cover element which covers a corresponding side wall part of a cushion member. The illustrated trim cover assembly (4) has a pair of decorative constricted parts (4c)(4c) formed in the seating surface portion (4a). The side wall portion (4b) is at its one end parts sewn with the peripheral parts of the seating surface portion (4a) at a sewn jointed point (4f), with the terminal end (4g) of the seating surface portion (4a) protruding outwardly from the sewn jointed point (4f). The lower die member (2) is, therefore, provided at its molding surface with a pair of support projections (21) (21) each being disposed in correspondence with the respective two constricted parts (4c) (4c) associated with the trim cover assembly (4), and the entire diameter or surface area of the lower die member (2) is designed relatively smaller than the outer diameter of the intermediate die member (1') as shown.
The molding surface of the lower die member (2) is formed such that its surface area is generally similar to that of the seating surface portion (4a), in order that the trim cover assembly (4), which is initially turned inside out, is placed on the lower die member (2), with the side wall portion (4b) depending around the peripheral edges of the lower die member (2), and the constricted parts (4c) (4c) being supported upon the projections (21) (21) respectively as shown.
In operation, the first step is to place the turned-over trim cover assembly (4) upon the lower die member (2) as shown in FIG. 1. The intermediate die member (1'), after having its three die pieces (1a') (1b') (1c') put together, is then pressedly placed on that lower die member (2) so that the lower contact edges (13A) (13B) of the intermediate die member (1') are pressed in place upon the peripheral edges of the lower die member (2), thereby collapsing and retaining therebetween the peripheral end areas of the seating surface portion (4a) of the trim cover assembly (4), whereupon a retained areas (4d) (4d') are defined in such peripheral end areas of the trim cover assembly (4), and therefore, as can be seen from FIGS. 1 and 2, the seating surface portion (4b) is pressingly retained at those retained areas (4d) (4d') between the contact ends (13A) (13B) of the intermediate die member (1') and the peripheral end parts of the lower die member (2). At the same time, the upper die member (3) is fitted on the upper opened side of the intermediate die member (2). Consequently, those three die members (3) (1') (2) are fitted securely together to form a unit of seat forming die having a hollow therein. Then, a base foaming material is injected through the port (31) into the hollow of thus-assembled die unit. A foaming is effected in the die unit so as to produce a foam cushion member (5') which is integral with the seating surface portion (4a) of the trim cover assembly (4), as in FIG. 2.
The above-described foaming process has been a common way, but the drawback has been with a resulting seat produced therefrom, in that an undesired projected area (P) is created at the corner of the seat as shown in FIG. 3. The reason is that, as best shown in FIG. 2, at the time when the lower contact end (13A) is pressed against the peripheral end area of the lower die member (2), the corresponding peripheral end part (at 4e) of the seating surface portion (4) are resiliently collapsed, creating the recess (at 51') at that retained area (4e) in the vicinity of the lower end of the die piece (1a'), and as such, the base foaming material, which is in a liquid form and injected in the die unit, is flowed into such recess of velley or slope (s), with the result that, after curing the base material into a foam solid body, a projected area (51') is defined at the upper corner of resultant foam cushion member (5') and due to the projected area (51'), the corresponding corner area (43) of the seating surface portion (4), which lies upon the projected area (51'), is pulled outwardly to create an undesired projection area (P) as shown in FIG. 3. It is noted here that, after curing of the base foaming material, both intermediate die and upper die members (1') (3) are removed from the lower die member (2), and the side wall portions (4b) (4b) as well as the seating surface portion (4a) are turned back to a normal state from the inside-out state, as can be seen from FIG. 3.
Hence, in the molding or forming process above, it has been difficult to produce a given contour of seat accurately with a good curvature on its corners, and such projection area (P) has impaired the aesthetic appearance of the seat, by creating an unpleasing irregularity or wrinkles on the surface of the seat.
Further, as seen in FIG. 3, the side wall portion (4b) is not stretched neatly over the corresponding portion of the cushion member (5') due to the outwardly protrusion of the sewn jointed point (4f) and terminal end (4f) associated with the trim cover assembly (4). This results in a poor appearance of the seat.


Award-winning food in the centre of the historic city of York

Having built a national reputation since 2002 for culinary quality and excellence, Café No.8 provides a range of outstanding food and drink in the heart of historic York.

Whether you want a hearty traditional breakfast, a light brunch or home-made cakes, or a sumptuous evening meal in the our intimate-yet-casual bistro, you will find award-winning, imaginative food served by friendly, professional teams.

We also provide event catering (inside or out) and planning services to bring the Café No.8 seal of quality to any event. Sourcing high-quality local produce and ingredients is at the heart of what we do, and our chefs avoid complicating matters by letting the quality of the ingredients do the talking. And we do all of this with first-rate customer service and at excellent value.

Café No.8 – simple, modern, quality.

Café No.8 Bistro

Our small-but-beautiful bistro is found on the busy and lively Gillygate in York. A street full of independent shops and businesses, it leads right into the heart of York through one of its ancient City gates

Café No.8 at home

You are now able to recreate the unique taste of Café No.8 in your own kitchen with our ‘at home’ range. Present bistro-quality meals at home without any loss of flavour or quality – and all without any of the stress!

“Amazing little find! Excellent restaurant!”

What an amazing little place. We visited here for lunch last week during our trip to York. A great value lunch at £12.50 for 2 courses. The gin cocktail was fantastic too. I had the Pate starter and the meatloaf burger, both of which were fantastic. The burger was melt in the mouth with homemade chips, absolutely fantastic food.

Macclesfield, England

“Gorgeous food”

Went for dinner and it was fully booked. The waitres who saw us told us to come back half hour later. She was really nice to fit us in. We had a gorgeus meat dish and excellent wine. The waitres was polite and kind. Bear in mind it’s a bistro. Menu and wine list are not long. Food made with fresh ingredients and carefully prepared takes time and is not the cheapest you can get. Excellent price – quality relation. Would go again and recommend to friends.

Maria C Sao Paulo

“Lovely food, friendly service”

Imaginative menu, very reasonable price, try the mushrooms with brie, and of course, the original dandilion and burdock

Bristol

“Coffee & Cake”

We enjoyed a coffee and cake at the coffee shop in the Merchants House. Table service and friendly staff.

Wendy R Colchester, United Kingdom

“Decent cup of coffee”

Went into the York Art Gallery to escape the rain and found a decent cup of coffee at a reasonable price.

Paul B Nottingham, United Kingdom

“The Guardian”

Whether you’re just dropping in for a bowl of soup – a warming, gently fiery Indian spiced tomato and ginger, say – or a 21-day aged steak with chips and a Yorkshire blue sauce, expect cooking shot through with a quiet, self-confident flair

The Guardian

“Excellent”

A friend and I were staying overnight and wanted to go somewhere unfussy but good quality without opting for a chain restaurant. Luckily we booked because on arrival for our table at 8.30pm we realised the restaurant was totally booked up on a Monday night!

The staff couldn’t have been more helpful, smiley, friendly, knew the menu, busy but attentive – bang on.
My friend chose the hot smoked salmon starter and duck main, both of which she said were perfectly executed – I tasted the starter and it was a well balanced dish with beetroot and a herby spread for the croutons. I had the steak pave which was very tasty and did exactly what you’d expect.

For dessert we shared the house favourite, the name of which escapes me but it was meringuey, gingery and rhubarby and had almond brittle too. personally we’d have had less of the brittle (or had it smashed into small nuggets) and more of the amazing rhubarb compote, but it was really delicious and I rarely have pudding!
Definitely recommended.

Joanna M Edinburgh, United Kingdom

“Would definitely go back for more!”

From the outside this looks like a tearoom, but don’t be put off. Book a table for an evening meal and enjoy a great, modern-style bistro menu. The food was excellent with a reasonably priced wine list and friendly staff. It will be on our list of places to go back to next time we visit York. Highly recommended.

Peterborough, United Kingdom

“Very nice place”

Cafe is part of the restaurant in Gillygate and is modern clean and well presented.

Menu is good choice and reasonable, we had a scone however the compote was extremely runny and difficult to get on scone but was very tasty.

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Attitudes of new mothers towards genetics and newborn screening.
To evaluate new mothers' opinions of genetics and newborn screening. An Australian tertiary referral hospital. 232 women who delivered a liveborn infant and had received written and verbal information on newborn screening from midwifery staff during their antenatal care. Participants were interviewed within 24 hours of blood being taken from their baby by heel prick for the newborn screen. Non-English speaking women were included using medical interpreters. The questionnaire evaluated opinions about newborn screening and parental consent. The opportunity was used to also question their views on the impact on lifestyle and discrimination of a theoretical diagnosis of genetic disease or carrier status in their baby. Descriptive data on mother's attitudes. 200 women consented to participate in the study (86.2% response). New mothers supported newborn screening programs where outcomes could be used to prevent or reduce the severity of a disease (85-86% support), but were less supportive if screening had been used to assist with future family planning (65%). The majority of women (86%) felt that parental consent was mandatory before newborn screening tests were performed. A similar number felt that consent would be required before blood samples could be used if a National DNA library were to be created. The majority of women expressed concern that a child with a genetic illness would face discrimination and difficulty obtaining insurance or employment. A third of women felt that even a carrier of a genetic illness would face similar discrimination. Acceptance of newborn screening programs is high but mothers consider the need for consent to be mandatory. They have concerns about discrimination children with genetic illnesses may face.


Formation of CaB6 in the thermal decomposition of the hydrogen storage material Ca(BH4)2.
Using a combination of high resolution X-ray powder diffraction and X-ray Raman scattering spectroscopy at the B K- and Ca L2,3-edges, we analyzed the reaction products of Ca(BH4)2 after annealing at 350 °C and 400 °C under vacuum conditions. We observed the formation of nanocrystalline/amorphous CaB6 mainly and found only small contributions from amorphous B for annealing times larger than 2 h. For short annealing times of 0.5 h at 400 °C we observed neither CaB12H12 nor CaB6. The results indicate a reaction pathway in which Ca(BH4)2 decomposes to B and CaH2 and finally reacts to form CaB6. These findings confirm the potential of using Ca(BH4)2 as a hydrogen storage medium and imply the desired cycling capabilities for achieving high-density hydrogen storage materials.


Hokkaido Ice Cream Puff

We are sharing the experience of authentic Hokkaido Ice Cream Puff from the way we bake fresh our puff, marry with high quality ice cream. We bake and serve our products from our hearts to the hand of customers.

Hokkaido Ice cream Puff comes in two flavours Vanilla & Chocolate. The puff is crunchy outside and tender inside. It is then serve with 9 different flavours ice cream. Ice cream is made from fresh ingredients and locally produced to show Indonesia's authenticity.

We aim to provide Hokkaido Japan, Food & Culture to people through creations. Hokkaido Ice Cream Puff is available in Malaysia, Singapore, Brunei and now in INDONESIA.


Q:

Ratio with elasticsearch

I have a list of customers with this structure:
{
     "name" : "Toya Romano",
     "hungry" : false,
     "date" : 1420090500020
}

I would like to get the ratio of people who are hungry. How can I do it with an ElasticSearch query? I am running ES 2.3.

A:

Rather a hacky approach because of this issue, but this should work:
{
  "size": 0,
  "aggs": {
    "whatever": {
      "filters": {
        "filters": [{}]
      },
      "aggs": {
        "all_people": {
          "filter": {}
        },
        "hungry_count": {
          "filter": {
            "term": {
              "hungry": true
            }
          }
        },
        "hungry_ratio": {
          "bucket_script": {
            "buckets_path": {
              "total_hungry": "hungry_count._count",
              "all": "all_people._count"
            },
            "script": "total_hungry/all"
          }
        }
      }
    }
  }
}

With the result like this:
     "buckets": [
        {
           "doc_count": 5,
           "all_people": {
              "doc_count": 5
           },
           "hungry_count": {
              "doc_count": 3
           },
           "hungry_ratio": {
              "value": 0.6
           }
        }
     ]


1 Corinthians 13:6 NLT

It does not rejoice about injustice but rejoices whenever the truth wins out.

NLT: New Living Translation Version Cancel Bible Language English Change Language {{#items}} {{local_title}} {{/items}} ← Language Cancel {{#items}} {{local_name}} {{/items}}