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Chicago examiner vol vii no 247 a m price one cent d Â° u z ered b * fess 30 cents per month tuesday october 5 1909 14 pages wayman forces all jury records to court as graft case evidence commissioners clerk and the office force subpoenaed to face grand jury police witnesses ready state's attorney lines up tes timony against command , . ers and politicians * renewal of the investigation of the jury commission was started yesterday by state's attorney wayman me took out a subpoena for the commis sion commanding its three members its chief clerk and office force to appear be fore the grand jury with all the books rec ords and jury lists used by the commis sioners in the work of drawing the grand and petit jurors for the courts of cook couuty the object of this move is to obtain the official lists of petit jurors especially those assigned for service in damage suits and other cases in the civil courts mr wayman expects to find in the petit jury lists the trail of a band of jury-fixers who operated in the interest of several powerful corporations which have benefited to the extent of more than 2,000,000 in low verdicts in damage suits brought against them during the last few years new indictments based on jury-fixing work of this kind are expected to be voted by the october grand jury which waa sworn iu yesterday by judge tuthill war on police continues activity in the warfare upon graft and corruption among the police force and poli ticians was also given a new impetus dur ing the day mr wayman the assistant state's attorney and the office force of in vestigators busied themselves examining witnesses who are to be sent before the grand jury later to tell stories cf graft which are expected to result in the indict ment of scores of police commanders and political workers a story of a hatchet-burying that failed was told around the criminal court building yesterday as part of the history of sunday's great german celebration it was said that state's attorney waymau thwarted a plot to get him to ride in the parade in the same carriage with mayor busse and thereby lead the public to be lieve that the men higher up in the city hall administration were mr wayman's friends and in no danger from the way man graft probe according to the story mr wayman heard rumors of the plauj of mutual friends to get him and thel mayor into the same band wagon then the prosecutor decided he would not ride in spite of the fact that he had been in vited by a delegation from the german societies a number of records in the jury commis sioners office were seized by state's at torney wayman last month when he caused the arrest of jury commissioner john j holland willis rayburn and nich olas j martin secretary to alderman kenna who were then indicted when the october grand jury was sworn in yesterday in open court jury commis sioner holland's colleagues william a am berg and james a mclane and the com missioner's chief clerk roswell mason were present and watched the impanel ing of the inquisitorial body that is ex pected to make a record lor investigations of graft jury-tampering and other forms of political and business corruption state's attorney wayman was not present he was represented by assistant state's attor neys victor arnold and thomas marshall a s cameron foreman after an exhaustive examination into the qu*liflcations of the veniremen judge tut hill ordered the oath administered to them alexander s cameron 1050 chase avenue whs selected to serve as foreman the court then briefly instructed the jury as to their duties and they retired their first session was brief they considered a few jail cases and after doing some other rou tine work took an adjournment until this morning following is a list of the members of the new grand jury alexander s cameron foreman member of the firm of cameron schroth & cam eron hugo g behrel foreman at 198 wa bash avenue paul c boettin plumber edward botthof department manager swan borglund contractor john h whit ing president of the whiting foundry company william j monroe a clerk os car a arnesen vice president at 240 south clinton street william hang pro prietor dry goods store christ grube con fectioner henry howe plumber prank a burgess president paper company henry kluth locomotive engineer itudolph ort mann of griffin car wheel company sam uel m wilson lumberman charles mal duer toolmaker charles h conklin sta tion agent sidney stern commercial trav eler george h ellis retired farmer peter c stohr asslstnnt traffic director ' union pacific railroad otto c bach manufac turer henry c freeman locomotive engi neer phillip t dunu master mechanic assistant state's attorney arnold an nounced that the grand jury will hold only half day sessions this month steals for chorus girl sympathy for a pretty chorus girl whose finances had taken a backward step made edward wirtli twenty-two years old a clerk employed by the public ruir company 150 slate street a thief be fore judge pake yesterday he pleaded guilty to a charge of larceny and was sentenced to one hour in the county jail and fined 5 and costs â€¢ divorcee and shelter king she wants back edmund kelley noted socialist lawyer dead he had devoted his wealth time and talents to solution of social prob lems for several years new york oct 4 edmund kelley the noted lawyer who for mauy years de voted his wealth time and talents to the solution of social problems died this morning of a ombiuation of complaints and will be buried wednesday from his home on north mountain at nyack-on-the hudson for nearly a year mr kelley had been in poor health suffering from a general breakdown he returned from paris where he did most of his legal wor i*,1 *, iu an effort to regain his health he was an authority on international law and was of late years known as a socialist having written a number of vol umes dealing with that philosophy of gor [ ernmeut grant heads 90-mile ride general leads 3t field offic*r in their horseback test waukegan 111 oct 4.-generai frederick grant head of the department of the lakes and thlrty-seveu officers all ranking above major started out at 8 o'clock this morning on a ninety-mile horseback ride which the war department requires of them they went to gage's lake to-day where they remain for the night then go thirty miles further after which they return to the fort by thurs day general grant's staff was also in the party officers were there from all parts of the department the corps of officers made quite a spectacle as they filed through the country iu their uniforms girl steals tries suicide officer knocks poison from hand after getting confession after confessing the theft of 40 and jewelry valued at hk from her mistress mrs h s ripley 1406 east fifty-seventh street and hiding the stolen property in an auaudoued water pipe miss celia fow ler twenty-three yean old ran past two detectives last evening and attempted tu commit suicide in toer room by drinking laudanum detective johu purcel ran into the room after the girl and knocked the bottle from her hand just as she was lift ing it to her mouth she was placed under the care of the matron at the woolawn police station and will be arraigned to-day bellew close to death actor sneezes burnt blood v**sel two doctors called . buffalo x y oct 4 that kyrle bcllew the celebrated actor did not bleed to death early to-day in lis room at the hotel statler is one of the mysteries of the mednal profession mr bcllew ruptured a blood vessel of the nose while sneezing as the result of a cold and bled so much that he became alarmed and summoned his companion actor charles o'connor who had an ad joining room two physicians were sent for and with some difficulty stopped the bleeding bfc kellew was in such a weak ened condition that he was unable to cave his bed all day morgan is denied palace italy refuses his x 000,000 offer for the hesrgia venice italy oct 4.-j plerpont mor gan's yearning to buy the hcggia at man tua formerly known as the corte beale one of the most famous royal residences in all europe has brought from him an offer of 55.000,000 for this magnificent structure hut the government holds that the heggia is one of the kingdom's monuments and relics so it was impossible to accept the american's reputed offer the heggia which dates from 1802 contains 000 rooms would be wife of guggenheim again former spouse starts fight to set aside divorce she obtained dunne claims old fraud youngest of famed brothers of smelter trust opposes being rewed the first skirmish in what promises to be a battle royal by a host of hlgh-pi'lcsti lawyers was fought yesterday before judge houore in the case of grace b guggenheim who is seeking to have set aside a divorce granted her iu 1!k)1 from william guggenheim the defendant is the youngest of the seven famous broth ers who are the most extensive silver mine owners iu the world and in control of the billion-dollar smelter trust upon the affidavit of former judge ed ward f dunne who granted the divorce mrs guggenheim and others that the de cree was obtained by conspiracy and fraud judge honorc issued an order iast june directing both sides to show cause why it shtiold not be set aside attorney colin q h fyffe was appointed as a friend of the court to investigate the mat ter ajid yesterday he appeared and said he was ready to report c e cleveland and denjamlu booker representing jacob newman local couusel for guggenheim fought for a continu ance this was objected to by william a dever who represented at the bar william m seabury the lawyer mrs guggenheim sent out from new york the question of whether arguments should begin at once on judge honore's juris diction was debated at length and the court finally set october 12 as the date for the discussion was she legal resident the main question at issue is whether mrs guggenheim was a legal resident of Illinois at the time she obtained the divorce the answer of guggenheim is now being prepared by samuel unter meyer of new york who probably will come to Chicago to eugage iu the battle when it begins in earnest when the present case was beguu former major dunne filed an affidavit in which he uaid that the decree which awarded mrs guggenhi u 160,000 alimony less than a month after her marriage iu new york had been obtained through fraud and conspiracy because at the time both were residents of new york but the com plainant was induced to come to Chicago to begin suit for divorce this from the man who as judge granted the divorce caused a sensation i merely brought the matter to the at tention of the court said mr dunne last night and my appearance iu the matter ends there but not my interest it was represented at the time the decrpe was granted that the complainant had been born iu Illinois and was a resident of the state sues first in new york recently mrs guggenheim sued guggen heim in new york for divorce asking ali mony and naming his present wife aimee steitfberg guggenheim as co-respondent she churged that the Chicago divorce was illegal a referee decided that the chi cago decree was valid previous to this action mrs guggen heim's third husband jules roger wahl obtained au annulment of his marriage in paris on the ground that the Chicago di vorce was not legal mrs guggenheim was miss urace brown until she was married to willium c herbert a naval officer who obtained a divorce on the ground of desertion she was married to guggeu heim in december 11)00 unknown to his family and three days later he sailed for europe without her iu february litol she found him in the dining room of the wellington hotel and gave him an exciting chase before he es caped her theu she filed the suit which resulted in the divorce she now calls illegal the charge is made that she was ignorant of the Illinois law that she was induced to come to Chicago and begin suit and that guggenheim came from europe expressly to compromise himself so that she could obtain her decree drys lose in connecticut defeated in fully a dozen towns â– itcp'ililicnns carry new haven new haven conn oct 4 in 102 of the i*lb cities and towns of connecticut the annual elections were held to-day the chief light made was upon the liquor license question the prohibitionists lost last year they won ninety seven towns they were defeated iu fully a dozen of the ninety-seven to-day the largest being winsted elections were held lu five of the cities new haven going republican by about 301 votes frank joyce defeating james b martin the democratic mayor by a small margin waterbury also re turned to the republican column after five years absence in the general elections about 110 towns chose republican officials against 120 a year ago alfonso ready to flee spain faciuk revolution over mo rocco war may overthrow kins paris oct 4 â€” the costly war in mo rocco is rapidly precipitating a crisis in spain which may bring about the over throw of king alfonso conditions in spain arc more nearly revolutionary than during the ban-dona uprising it is un derstood all arrangements have been made for a hurried departure of the royal fam ily if the storm breaks crane recalled as he starts for china Chicago diplomat returns to washington to-day for further instructions knox anxious to see him new chino â€” japan treaties said to be cause of sud den change of plans ran fiuncisco oct 4.-t'haries k franc of Chicago newly appointed minister to china who was to have sailed to-morrow ou the steamer mongolia has been recalled to washington he was ready to board the ship to-day but has cancelled his reserva tion thnt tlirip l anything unusual in miiuecllou with this sudden recall is denied by mr crane i am to go back for further instruc tions he says further than that he would not discuss the subject in fact he tried to treat the matter as coinnionplaci that he was dis appointed however was apparent through his mask of indifference t 3 o'brien minister to tnpun is also booked on the steamer mongolia and it 1 known that a very pleasant voyage across was anticipated yesterday the ministers met at the fairmont hotel and discussed plans for whiling away the time on the voyage to-night mr crane attended a banquet given in his honor by the cham ber of commerce later he was the host at a dinner given to mr o'brien and a number of prominent business men most of the guests at the dinner were with mr crane when he received a notice of his re call to washington they had been with the diplomat on a trip around the city and had goue to the hotel to bid him good by but a telegram awaiting mr crane changed his plaus and the adieus were not made Â„ Â» mr crane expcct6 to leave for washing ton to-morrow morning to close frieuds he said he did not anticipate a long star in washington and expected to return to san francisco in time to sail ou the steamer korea october 0 that this is his present plan is evidenced by the an nouncement that his family will reruaiu in san francisco china japan treaties cause crane's return washington oct 4 minister crane on leaving here had full instructions both as to the situation in manchuria and the firm establishment of the eastern bureau the object of which was to look afler the commercial rights of the united states in the east and more especially in mancburi-i where the disturbing anti-american com mercial factor is japan at the time mr crane had his interviews here the information at f*ie state depart ment was that china had compromised her differeuces with japan over the autung mukdcn railroad and in a manner that was satisfactory for the time being to the united states still mr crane's main pri vate instruction was to report on the com mercial status in manchurta while mr crane wan en route to the pa cific there were notable developments in japan and these too occurred after the president's reiteration tnat there was the most acceptable relation between japan and the united states refore mr crane reached the coast came the news that japan and china had en tered upon two new treaties one of which gave japan a controlling interest in cer tain manchurinn mines and the other prac tically made japan the arbitrator of any further extension in manchuria p>oth of th*ie treaties were in direct vio lation of the principle of the open door and the portsmouth treaty if they were not followed by supplementary treaties or writ ten understandings which made clear ja pan's attitude on the open door the comment at the state department on the chine-japan treaties was that they were wholly indefensible and demanded ex planation it is the opinion here that it would be useless for mr crane to proceed to china without new instructions which obviously ought not to be telegraphed or cabled i'ersoual instructions it is true might easily be given by president Taft on the coast but there are certain powers and special instructions which are only effective under the seal of the department lu order to hi . ach additional powers as are needed and the beuetit of inslruc tions from secretary of state knox it was necessary for mr crane to come here certainly in the opinion of state depart ment officials the new moves of japan in manchuria were regarded as of the high est importance and were to be handled by mr crane 465,000 in gifts to yale w 1 and h t slonn donate 842 000 a g viimlermlt fÂ«5,0oo new haven conn oct 4 yale to day was given 120.000 by william d sloan and henry t sloan of new york city the sum will be used to build a laboratory for the study of physics and will be en joyed by the academic the scientific and the graduate departments of the university within a year the familv of the late johu sloan has given vale si(h),oik bringing the total gifts of the family to 736,080 al fred g vanderblh to-day gave yale 52.">,000 to lie used as an addition to the general en dowment fund this is his second 2.">.<kk gift george hewitt myers has given 13 000 toward the endowment of the school of forestry roosevelts quit venice venice oct 4 mrs theodore roose velt miss ethel roosevelt and miss carow who have been visiting here for the last few days left venice this afternoon they went direct to padua where they visited the university and cathedral wright flies over gotham hovers above battleships tells of historic air trip swoops down over fighting vessels of half a dozen na tions just to give jackies better view of machine battles through treacherous air currents far above the streets of manhattan while thousands gaze in awe daring aviator gives matter of-fact account of sensa tional trip from governor's island past grant's tomb l y e'w york oct 4 after wilbur wright had made his sensa /\ j tional flight he was greeted by a crowd of eager questioners \ \ at first he replied to all with his whimsical smile and the two \. words flying some finally the story of his trip up the hudson and around grant's tomb was wormed out of him a sentence at a time it came in sections an answer to a question here a volunteered statement or impression there wright never told a story in his life and probably never will but that takes nothing from the interest of his account did you see many people was one of the first questions i saw a few on the piers on the tops of buildings and a few on the hillsides then there was a moment's silence he volunteered they looked like ants you went higher than the skyscrapers oh no i didn't he answered with assurance i kept away from the skyscrapers i tried to average about 200 feet about the height of an average new york building but no skyscrapers my brother flies high again the half smile and again the brotherly spirit of orville and wilbur showed itself have any trouble with the winds well drawled the human bird when i was off twenty-third street i knew there was something doing perhaps it was the metropoli tan tower and the flatiron sending greetings apyway the air was boiling ad.f 1 - i dipped down a little where the going was steadier didvou really circle grant's tomb i went in toward the shore when off fhe tomb but the wind cur rents were contrary and i decided to stay over the river what warship did you use as turning point i'm sure i don't know which one it was laughed wright i was busy with a ship of my own could the foreign ships have punctured you with their guns when i saw the jackies tumbling up on deck and heard their cheers arising i swooped down many feet to give them a better view said wright they could have reacted me then i suppose with their rapid-fire guns but they did not if there had been any danger of it i could have remained much higher very much higher by this time the official time had been figured and there was specu lation as to the reason for the quick trip back i bucked the wind going up the river said wright coming back i played the bird and did not run my motor at full force i could have made the return trip much faster had speed been particularly desired wilbur wright birdlike machine startles foreign navai officers as it swoops past new york oct 4 wilbur wright this morning accomplished the most spec tacular aeroplaue flight in america's his tory when he glided over governor's island passed the battery up the hudson river to a point a mile above grant's tomb and returned to a sand pile within three feet of his starting point without a single voluntary flatter his wonderful flight threw nlilinpresslble manhattan into a flutter and startled the nations of eu rope through the officers of the warship over which he passed when he was starting this afternoon to win the prize of 1,300 offered by the new york american for hurdling the east hiver bridges there caine an accident which ended the life of the victorious airship in a jiffy and narrowly escaped seriously injuring the bird inao himself the aeroplane was on the mono rail oiled and keyed and rady to start on what wright hoped would be an absolutely record-breaking flight of an hour the conditions he declared were ideal his audience the greatest and his desire most keen wright stood behind the machine trying to start the propellers his mechanician was pumping oil into the refractory en gine the motor missed fire repeatedly the propellers stuck bucked and grumbled aviator just misses death suddenly there was a slight explosion a flare-back they call it a chunk of brass flew out of the engine tore a jagged bole in the canvas top of the upper bi plane nii'i'owly missed the head of tlje viator and buried itself ln the sand wright shrugged his shoulders and threw up his arms with such significance that the women in the crowded newspaper pen who knew least about mechanics un derstood that the trial was all over then he smiled that weird philosophical smile that comes out of the side of his face and he kept on smiling the hudson-fulton aeroplane flight is over gentlemen he announced we are forced to miss the best weather conditions i have ever encountered disappointed as was the crowd they cheered the spirit of the man who wag able to smile ill the face of such adversity lle membei'iiig thjfcflight of the morning they cheered and jfl members of the aeronautic committee a^b-ed him that he bad earned and would receive the full con mmm tract price said to be 10.000 for the fly ing demonstrations he gave new york last weduesduy and this morning figures of wright's record here are the figures of wright's record breaking flight up the hudson u:o3 o'clock sailed governor's island turned grant's tomb 10:13:30 landed governor's island 10:116:30 time in the air 33 minutes and 33 sec onds distance almost 20 miles time going 20 minutes 30 stconds time returning 13 minutes 3 seconds then may be listed the matters in which the flight was unique superior record breaking iu the first place more people saw parts of the flight than ever before witnessed an aeroplane feat thanks to the skyscrapers and the deep canyons they make across manhattan island the aviator encountered more dangerous wind currents than any a biplane had ever be fore successfully contended against offi cials of half dozen nations including great britain france and germany watched the flight from the decks of their battleships and cruisers and perhaps wondered what would huppen to them if wilbur wright of dayton 0 should suddenly take it into his head to drop dynamite shells it was the most even flight that the wright bi plane has yet attempted at least in amer ica i'm going up anyway it was blowing some when wright reached governor's island shortly before 9 o'clock this morning lie sniffed at the wind tried his handkerchief and match testa and announced i'm going up any way the motor purred the twin propellors swished through the air and the aeroplane glided down the rail dipped as it always does then rose into the air with a gradual upward glide there was no circling about the island on this flight wright headed straight for the entrance to the hudson sailing a course slraighter than fulton ever could have gotten out of the urst steamboat those on the battery saw dm disappear in the indian summer haze further up the north river the crowds which rushed to the piers and the even grea'er crowds malsh strikes last blow to stave off verdict files new citations to tie up circuit court of appeals while lawyers make ef fort to raise cash on roads hurried conference followed by trip of capitalists to in dianapolis indiana proper ties banker's last hope sims certain verdict will stand miller will insist on ruling on new legal points that he has discovered what is considered as a move to delay the decision of the united states circuit court of appeals in the john b walsh case which is due to be handed down th'm morning is seen in the action taken lat yesterday afternoon by walsh's counsel attorney john s miller filed a document with the clerk of the united states circuit court of appeals embracing citations of recently decided cases which he believc3 will have a decided bearing on his client's case the filing of this document at practically the eleventh hour was made the basis ol much speculation among those who hav been following the walsh case carefully and the consensus of opinion is that tha walsh counsel fearing a decision adver.o to their client's interests have taken this step to have the decision held up for at least a few day3 walsh's ouii_e 1 jm sist that the citations handed the court be read and passed upon before the decision is handed down following closely upon this move and a conference between lepre.tii mves of the bankers holding the walsh 6e rifles and counsel for mr walsh a hurried trip to indianapolis was made by representa tives of each side which is believed to jnean that some definite more is to be made by those who are expected to come to walsh's aid it is known that john w walsh son of the aged danker-rail road man yesterday conducted a party of capitalists over the railroad properties nf his father in indiana and i is considered certain that all persons interested rill meet to-day in iudianapolfs financial aid for walsh is expected to be the re sult quick solution is rumored after the conference of yesterday attor ney lesing rosenthal representing the guarantors of walsh's notes declared that nothing definite had been accomplished but that all interested were n-orklug in harmony in the light of after events when b k boisot president of the first trust and savings bank the trustee o the walsh collateral and ja s r hutch ins attorney for the illinoi trait and savings bank started post haste for 11 dianapolis it is believed ihnt th walsh attorneys offered some quh-k bolnuon of the difficulties e c ritsliec cn e of tha walsh counsel also left town and is be lieved to have gone to indianapolis avhile none of the interested perions will discuss possibilities it is th general belief that the meeting in indianapolis will he attended by representative ofl eastern capitalists and tlm ample ti is will he forthcoming southern iudlana railroad officials ad mitted last night that the purpose nf the special train inspection of the system waa in view of selling the property but they deny all knowledge of the identity of who is represented by the inspection party general manager wells ln terra haute last night denied that j i hill had any thing to do with the dee citations along walsh line of defense the citations of recent decisions filed by attorney miller bear upon the question of inconsistency and repugnancy of the walsh verdict they are ln support of the con tention made by the walsh attorneys that the verdict was inconsistent and that the different counts on which their client was indicted and found guilty disagreed with each other and that therefore the verdict should be set aside there is no occasion for any excitement as the result of the filing of that docn ment said attorney miller such is hot customary i found these ne 1 citations of cases decided since i made up my argu ment to the court and would have filed them sooner had it been possible united states district attorney sims did not appear worried over th filing of the additional citations he believes that ther a will not even cause delay .. will be de elded immediately by the npellate judges i believe the johu r walsh verdict will be upheld declared attorney sims last night mr sims said the redivi on of northern Illinois iuto new federal court districts after the draft of the grand jury which indicted walsh might furnish sufficient grounds for admission of the case into th united st-tes supreme court but tha if he did not believe the redisricting would invalidate the work of the grand jury _Â»_- . rt a continued in 4th page 4tn column v w weather forecast m t\i Chicago and vicinity fair tues f \*? day and probably wednesday mod j \\ erate winds becoming southeasterly hjf h many a Chicago fortune m j was founded on real estate you !.( v t\jgk can found your fortune on real fvjji f & estate if you will but read the c j vi real estate ads jj j9 examiner want pages l "

Chicago examiner vol vii no 247 a m price one cent d Â° u z ered b * fess 30 cents per month tuesday october 5 1909 14 pages wayman forces all jury records to court as graft case evidence commissioners clerk and the office force subpoenaed to face grand jury police witnesses ready state's attorney lines up tes timony against command , . ers and politicians * renewal of the investigation of the jury commission was started yesterday by state's attorney wayman me took out a subpoena for the commis sion commanding its three members its chief clerk and office force to appear be fore the grand jury with all the books rec ords and jury lists used by the commis sioners in the work of drawing the grand and petit jurors for the courts of cook couuty the object of this move is to obtain the official lists of petit jurors especially those assigned for service in damage suits and other cases in the civil courts mr wayman expects to find in the petit jury lists the trail of a band of jury-fixers who operated in the interest of several powerful corporations which have benefited to the extent of more than 2,000,000 in low verdicts in damage suits brought against them during the last few years new indictments based on jury-fixing work of this kind are expected to be voted by the october grand jury which waa sworn iu yesterday by judge tuthill war on police continues activity in the warfare upon graft and corruption among the police force and poli ticians was also given a new impetus dur ing the day mr wayman the assistant state's attorney and the office force of in vestigators busied themselves examining witnesses who are to be sent before the grand jury later to tell stories cf graft which are expected to result in the indict ment of scores of police commanders and political workers a story of a hatchet-burying that failed was told around the criminal court building yesterday as part of the history of sunday's great german celebration it was said that state's attorney waymau thwarted a plot to get him to ride in the parade in the same carriage with mayor busse and thereby lead the public to be lieve that the men higher up in the city hall administration were mr wayman's friends and in no danger from the way man graft probe according to the story mr wayman heard rumors of the plauj of mutual friends to get him and thel mayor into the same band wagon then the prosecutor decided he would not ride in spite of the fact that he had been in vited by a delegation from the german societies a number of records in the jury commis sioners office were seized by state's at torney wayman last month when he caused the arrest of jury commissioner john j holland willis rayburn and nich olas j martin secretary to alderman kenna who were then indicted when the october grand jury was sworn in yesterday in open court jury commis sioner holland's colleagues william a am berg and james a mclane and the com missioner's chief clerk roswell mason were present and watched the impanel ing of the inquisitorial body that is ex pected to make a record lor investigations of graft jury-tampering and other forms of political and business corruption state's attorney wayman was not present he was represented by assistant state's attor neys victor arnold and thomas marshall a s cameron foreman after an exhaustive examination into the qu*liflcations of the veniremen judge tut hill ordered the oath administered to them alexander s cameron 1050 chase avenue whs selected to serve as foreman the court then briefly instructed the jury as to their duties and they retired their first session was brief they considered a few jail cases and after doing some other rou tine work took an adjournment until this morning following is a list of the members of the new grand jury alexander s cameron foreman member of the firm of cameron schroth & cam eron hugo g behrel foreman at 198 wa bash avenue paul c boettin plumber edward botthof department manager swan borglund contractor john h whit ing president of the whiting foundry company william j monroe a clerk os car a arnesen vice president at 240 south clinton street william hang pro prietor dry goods store christ grube con fectioner henry howe plumber prank a burgess president paper company henry kluth locomotive engineer itudolph ort mann of griffin car wheel company sam uel m wilson lumberman charles mal duer toolmaker charles h conklin sta tion agent sidney stern commercial trav eler george h ellis retired farmer peter c stohr asslstnnt traffic director ' union pacific railroad otto c bach manufac turer henry c freeman locomotive engi neer phillip t dunu master mechanic assistant state's attorney arnold an nounced that the grand jury will hold only half day sessions this month steals for chorus girl sympathy for a pretty chorus girl whose finances had taken a backward step made edward wirtli twenty-two years old a clerk employed by the public ruir company 150 slate street a thief be fore judge pake yesterday he pleaded guilty to a charge of larceny and was sentenced to one hour in the county jail and fined 5 and costs â€¢ divorcee and shelter king she wants back edmund kelley noted socialist lawyer dead he had devoted his wealth time and talents to solution of social prob lems for several years new york oct 4 edmund kelley the noted lawyer who for mauy years de voted his wealth time and talents to the solution of social problems died this morning of a ombiuation of complaints and will be buried wednesday from his home on north mountain at nyack-on-the hudson for nearly a year mr kelley had been in poor health suffering from a general breakdown he returned from paris where he did most of his legal wor i*,1 *, iu an effort to regain his health he was an authority on international law and was of late years known as a socialist having written a number of vol umes dealing with that philosophy of gor [ ernmeut grant heads 90-mile ride general leads 3t field offic*r in their horseback test waukegan 111 oct 4.-generai frederick grant head of the department of the lakes and thlrty-seveu officers all ranking above major started out at 8 o'clock this morning on a ninety-mile horseback ride which the war department requires of them they went to gage's lake to-day where they remain for the night then go thirty miles further after which they return to the fort by thurs day general grant's staff was also in the party officers were there from all parts of the department the corps of officers made quite a spectacle as they filed through the country iu their uniforms girl steals tries suicide officer knocks poison from hand after getting confession after confessing the theft of 40 and jewelry valued at hk from her mistress mrs h s ripley 1406 east fifty-seventh street and hiding the stolen property in an auaudoued water pipe miss celia fow ler twenty-three yean old ran past two detectives last evening and attempted tu commit suicide in toer room by drinking laudanum detective johu purcel ran into the room after the girl and knocked the bottle from her hand just as she was lift ing it to her mouth she was placed under the care of the matron at the woolawn police station and will be arraigned to-day bellew close to death actor sneezes burnt blood v**sel two doctors called . buffalo x y oct 4 that kyrle bcllew the celebrated actor did not bleed to death early to-day in lis room at the hotel statler is one of the mysteries of the mednal profession mr bcllew ruptured a blood vessel of the nose while sneezing as the result of a cold and bled so much that he became alarmed and summoned his companion actor charles o'connor who had an ad joining room two physicians were sent for and with some difficulty stopped the bleeding bfc kellew was in such a weak ened condition that he was unable to cave his bed all day morgan is denied palace italy refuses his x 000,000 offer for the hesrgia venice italy oct 4.-j plerpont mor gan's yearning to buy the hcggia at man tua formerly known as the corte beale one of the most famous royal residences in all europe has brought from him an offer of 55.000,000 for this magnificent structure hut the government holds that the heggia is one of the kingdom's monuments and relics so it was impossible to accept the american's reputed offer the heggia which dates from 1802 contains 000 rooms would be wife of guggenheim again former spouse starts fight to set aside divorce she obtained dunne claims old fraud youngest of famed brothers of smelter trust opposes being rewed the first skirmish in what promises to be a battle royal by a host of hlgh-pi'lcsti lawyers was fought yesterday before judge houore in the case of grace b guggenheim who is seeking to have set aside a divorce granted her iu 1!k)1 from william guggenheim the defendant is the youngest of the seven famous broth ers who are the most extensive silver mine owners iu the world and in control of the billion-dollar smelter trust upon the affidavit of former judge ed ward f dunne who granted the divorce mrs guggenheim and others that the de cree was obtained by conspiracy and fraud judge honorc issued an order iast june directing both sides to show cause why it shtiold not be set aside attorney colin q h fyffe was appointed as a friend of the court to investigate the mat ter ajid yesterday he appeared and said he was ready to report c e cleveland and denjamlu booker representing jacob newman local couusel for guggenheim fought for a continu ance this was objected to by william a dever who represented at the bar william m seabury the lawyer mrs guggenheim sent out from new york the question of whether arguments should begin at once on judge honore's juris diction was debated at length and the court finally set october 12 as the date for the discussion was she legal resident the main question at issue is whether mrs guggenheim was a legal resident of Illinois at the time she obtained the divorce the answer of guggenheim is now being prepared by samuel unter meyer of new york who probably will come to Chicago to eugage iu the battle when it begins in earnest when the present case was beguu former major dunne filed an affidavit in which he uaid that the decree which awarded mrs guggenhi u 160,000 alimony less than a month after her marriage iu new york had been obtained through fraud and conspiracy because at the time both were residents of new york but the com plainant was induced to come to Chicago to begin suit for divorce this from the man who as judge granted the divorce caused a sensation i merely brought the matter to the at tention of the court said mr dunne last night and my appearance iu the matter ends there but not my interest it was represented at the time the decrpe was granted that the complainant had been born iu Illinois and was a resident of the state sues first in new york recently mrs guggenheim sued guggen heim in new york for divorce asking ali mony and naming his present wife aimee steitfberg guggenheim as co-respondent she churged that the Chicago divorce was illegal a referee decided that the chi cago decree was valid previous to this action mrs guggen heim's third husband jules roger wahl obtained au annulment of his marriage in paris on the ground that the Chicago di vorce was not legal mrs guggenheim was miss urace brown until she was married to willium c herbert a naval officer who obtained a divorce on the ground of desertion she was married to guggeu heim in december 11)00 unknown to his family and three days later he sailed for europe without her iu february litol she found him in the dining room of the wellington hotel and gave him an exciting chase before he es caped her theu she filed the suit which resulted in the divorce she now calls illegal the charge is made that she was ignorant of the Illinois law that she was induced to come to Chicago and begin suit and that guggenheim came from europe expressly to compromise himself so that she could obtain her decree drys lose in connecticut defeated in fully a dozen towns â– itcp'ililicnns carry new haven new haven conn oct 4 in 102 of the i*lb cities and towns of connecticut the annual elections were held to-day the chief light made was upon the liquor license question the prohibitionists lost last year they won ninety seven towns they were defeated iu fully a dozen of the ninety-seven to-day the largest being winsted elections were held lu five of the cities new haven going republican by about 301 votes frank joyce defeating james b martin the democratic mayor by a small margin waterbury also re turned to the republican column after five years absence in the general elections about 110 towns chose republican officials against 120 a year ago alfonso ready to flee spain faciuk revolution over mo rocco war may overthrow kins paris oct 4 â€” the costly war in mo rocco is rapidly precipitating a crisis in spain which may bring about the over throw of king alfonso conditions in spain arc more nearly revolutionary than during the ban-dona uprising it is un derstood all arrangements have been made for a hurried departure of the royal fam ily if the storm breaks crane recalled as he starts for china Chicago diplomat returns to washington to-day for further instructions knox anxious to see him new chino â€” japan treaties said to be cause of sud den change of plans ran fiuncisco oct 4.-t'haries k franc of Chicago newly appointed minister to china who was to have sailed to-morrow ou the steamer mongolia has been recalled to washington he was ready to board the ship to-day but has cancelled his reserva tion thnt tlirip l anything unusual in miiuecllou with this sudden recall is denied by mr crane i am to go back for further instruc tions he says further than that he would not discuss the subject in fact he tried to treat the matter as coinnionplaci that he was dis appointed however was apparent through his mask of indifference t 3 o'brien minister to tnpun is also booked on the steamer mongolia and it 1 known that a very pleasant voyage across was anticipated yesterday the ministers met at the fairmont hotel and discussed plans for whiling away the time on the voyage to-night mr crane attended a banquet given in his honor by the cham ber of commerce later he was the host at a dinner given to mr o'brien and a number of prominent business men most of the guests at the dinner were with mr crane when he received a notice of his re call to washington they had been with the diplomat on a trip around the city and had goue to the hotel to bid him good by but a telegram awaiting mr crane changed his plaus and the adieus were not made Â„ Â» mr crane expcct6 to leave for washing ton to-morrow morning to close frieuds he said he did not anticipate a long star in washington and expected to return to san francisco in time to sail ou the steamer korea october 0 that this is his present plan is evidenced by the an nouncement that his family will reruaiu in san francisco china japan treaties cause crane's return washington oct 4 minister crane on leaving here had full instructions both as to the situation in manchuria and the firm establishment of the eastern bureau the object of which was to look afler the commercial rights of the united states in the east and more especially in mancburi-i where the disturbing anti-american com mercial factor is japan at the time mr crane had his interviews here the information at f*ie state depart ment was that china had compromised her differeuces with japan over the autung mukdcn railroad and in a manner that was satisfactory for the time being to the united states still mr crane's main pri vate instruction was to report on the com mercial status in manchurta while mr crane wan en route to the pa cific there were notable developments in japan and these too occurred after the president's reiteration tnat there was the most acceptable relation between japan and the united states refore mr crane reached the coast came the news that japan and china had en tered upon two new treaties one of which gave japan a controlling interest in cer tain manchurinn mines and the other prac tically made japan the arbitrator of any further extension in manchuria p>oth of th*ie treaties were in direct vio lation of the principle of the open door and the portsmouth treaty if they were not followed by supplementary treaties or writ ten understandings which made clear ja pan's attitude on the open door the comment at the state department on the chine-japan treaties was that they were wholly indefensible and demanded ex planation it is the opinion here that it would be useless for mr crane to proceed to china without new instructions which obviously ought not to be telegraphed or cabled i'ersoual instructions it is true might easily be given by president Taft on the coast but there are certain powers and special instructions which are only effective under the seal of the department lu order to hi . ach additional powers as are needed and the beuetit of inslruc tions from secretary of state knox it was necessary for mr crane to come here certainly in the opinion of state depart ment officials the new moves of japan in manchuria were regarded as of the high est importance and were to be handled by mr crane 465,000 in gifts to yale w 1 and h t slonn donate 842 000 a g viimlermlt fÂ«5,0oo new haven conn oct 4 yale to day was given 120.000 by william d sloan and henry t sloan of new york city the sum will be used to build a laboratory for the study of physics and will be en joyed by the academic the scientific and the graduate departments of the university within a year the familv of the late johu sloan has given vale si(h),oik bringing the total gifts of the family to 736,080 al fred g vanderblh to-day gave yale 52.">,000 to lie used as an addition to the general en dowment fund this is his second 2.">.


1. Introduction {#sec1-molecules-24-01923}
===============

Licorice is a perennial herb of the genus *Glycyrrhiza*, mainly distributed in Xinjiang, Gansu, Ningxia and Inner Mongolia in China. The application of licorice has permeated many fields, including food, tobacco, cosmetics, health products and pharmaceuticals \[[@B1-molecules-24-01923]\]. The pharmacopoeia of the People's Republic of China contains *G. uralensis*, *G. glabra* and *G. inflata* as medicinal materials. Their roots and rhizomes are the medicinal parts, which mainly contain triterpenoids and flavonoids. To date, more than 400 compounds have been isolated from licorice \[[@B2-molecules-24-01923]\]. It is reported that licorice shows significant efficacy in relieving coughing and asthma \[[@B3-molecules-24-01923]\], hepatoprotective \[[@B4-molecules-24-01923]\], anti-inflammatory \[[@B5-molecules-24-01923]\], anti-virus \[[@B6-molecules-24-01923]\], anti-ulcer \[[@B7-molecules-24-01923]\] and anti-diabetes \[[@B8-molecules-24-01923]\] activities.

The underground part of licorice has been used for the treatment of many diseases for a long time in China. The aerial parts of licorice are not widely used, usually resulting in the waste of resources. However, the aerial parts possess a high nutritional value \[[@B9-molecules-24-01923]\]. Several compounds have been identified in the aerial parts, including 75 flavonoids, 16 dihydrostilbenes and 18 amino acids \[[@B10-molecules-24-01923]\]. It has been reported that the aerial parts have numerous beneficial effects, such as anti-coagulation, anti-thrombosis \[[@B11-molecules-24-01923]\], anti-oxidation \[[@B12-molecules-24-01923],[@B13-molecules-24-01923]\], anti-prostatitis \[[@B14-molecules-24-01923]\], anti-microbial \[[@B15-molecules-24-01923]\] and other biological activities.

Inflammation is the body's stress feedback to noxious stimuli, tissue damage, and infections, leading to inflammatory diseases, such as infections, metabolic diseases, cancer and aging \[[@B16-molecules-24-01923]\]. Macrophages are important immune cells and play an important role in the inflammatory process. NO is one of important inflammatory mediators secreted by macrophages \[[@B17-molecules-24-01923]\], and excessive production of NO will lead to cell damage and tissue necrosis, promoting the occurrence of inflammatory diseases. Thus, the inhibition of NO production is important for the treatment of inflammation and complications.

In this study, we aimed to find the bioactive compounds from the leaves of *G. uralensis*. As a result, four new compounds (**1**--**4**), together with eight known compounds (**5**--**12**), were isolated and identified ([Figure 1](#molecules-24-01923-f001){ref-type="fig"}). In addition, compounds **1**--**9** showed stronger anti-inflammatory activities by suppressing NO production in RAW264.7 cells.

2. Results and Discussion {#sec2-molecules-24-01923}
=========================

2.1. Identification of Compounds {#sec2dot1-molecules-24-01923}
--------------------------------

Compound **1** was obtained as a brown oil. The HR-ESI-MS date of **1** showed an \[M + H\]^+^ ion at *m*/*z* 353.1742, corresponding to a molecular formula of C~22~H~24~O~4~ ([Figure S3, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}). The UV spectrum of **1** had absorption maxima at 250, 259 and 284 nm, which indicated that **1** had an aromatic heterocyclic ring ([Figure S2, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}).

The ^1^H-NMR spectrum ([Figure S4, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) showed four aromatic protons ([Table 1](#molecules-24-01923-t001){ref-type="table"}). Two protons at δ~H~ 6.58 (1H, br s) and 6.75 (1H, d, *J* = 1.2 Hz) displayed meta-coupling aryl moiety and other proton resonances at δ~H~ 6.58 (1H, br s) and 6.43 (1H, d, *J* = 1.6 Hz) revealed one tetra-substituted benzene ring. Three signals at δ~H~ 3.18 (2H, d, *J* = 7.2 Hz), 5.11 (1H, t, *J* = 7.2 Hz) and 1.66 (6H, s) were due to one prenyl group. The signals at δ~H~ 6.83 (1H, d, *J* = 1.2 Hz) and 7.71 (1H, d, *J* = 1.2 Hz) were assigned to one benzofuran ring \[[@B18-molecules-24-01923]\]. The signal of one methoxy group at δ~H~ 3.64 (3H, s) was also observed. One hydroxy was assigned to C-3 according to the down-shifted chemical signal of C-3 at δ~C~ 149.7 compared to that of **5**. In the analysis of ^13^C-NMR ([Table 1](#molecules-24-01923-t001){ref-type="table"}), ^1^H-detected heteronuclear single quantum coherence (HSQC) and distortionless enhancement by polarization transfer (DEPT, [Figures S5--S7, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) spectra data revealed one methoxy at δ~C~ 59.6, one prenyl at δ~C~ 28.3, 123.4, 134.3, 25.5, 17.6, one tetra-substituted benzene ring at δ~C~ 114.5, 119.7,135.0, 149.7, 143.7, 134.3 and one benzofuran ring at δ~C~ 105.1, 143.4, 118.6, 136.9, 116.7, 155.4, 95.4, 155.38.

The prenyl group in compound **1** was linked to C-5(δ~C~ 134.3), which was confirmed by the ^1^H-detected heteronuclear multiple bond correlation (HMBC) correlations ([Figure S8, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) of H-1′ (δ~H~ 3.18) with C-5 (δ~C~ 134.3), C-4 (δ~C~ 143.7), and C-6 (δ~C~ 119.8). The methoxy group was attached to C-4 according to the HMBC correlations of δ~H~ 3.64 (-OCH~3~) with 4-OCH~3~(δ~C~ 59.6). The connection of the benzofuran ring to C-8 was clearly proved by HMBC correlations of H-8 (δ~H~ 2.93) with C-10 (δ~C~ 118.6) and C-14 (δ~C~ 111.7), of H-12 (δ~H~ 6.75) of C-10 (δ~C~ 118.6), C-11 (δ~C~ 155.4) and C-14 (δ~C~ 111.7). Other correlations, such as H-7 (δ~H~ 2.73) with C-1 (δ~C~ 135.0), C-6 (δ~C~ 119.8) and C-8(δ~C~ 34.6), H-6 (δ~H~ 6.43) with C-2 (δ~C~ 114.5), C-4 (δ~C~ 143.7) and C-7 (δ~C~ 35.7), provided further support for the confirmation of the structure. All of the above information determined that the structure of **1** was 3-hydroxy-1-(2-(3-hydroxy-4-methoxy-5-(3-methyl-2-butenyl)-phenyl)-ethyl) benzofuran, denoted as licostilbene A.

Compound **2** was obtained as brown oil and had the molecular formula C~25~H~32~O~4~, as inferred from the HR-ESI-MS in positive mode \[M + H\]^+^ at *m*/*z* 397.2362 (calcd. for C~25~H~32~O~4~, 397.2373) ([Figure S12, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}). The UV spectrum of **2** had absorption maxima at 270 and 282 nm, which indicated that it had benzene rings ([Figure S11, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}).

The A ring of **2** displayed the same proton and carbon signals as those of the A ring of α,α′-dihydro-3,5,4′-trihydroxy-4,5′-diisopentenylstilbene (**5**), and the B ring of **2** was the same as the C ring of licostilbene A (**1**) ([Table 1](#molecules-24-01923-t001){ref-type="table"}). The ^1^H-NMR spectrum ([Figure S13, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) showed four aromatic proton resonances at δ~H~ 6.54 (1H, d, *J* = 1.6 Hz), 6.40 (1H, d, *J* = 1.6 Hz) and 6.13 (2H, s) ([Table 1](#molecules-24-01923-t001){ref-type="table"}). The signal at δ~H~ 3.64 (3H, s) was assigned to one methoxy group. Signals at δ~H~ 1.59 (3H, s) 1.67 (6H, s), 1.68 (3H, s), 3.19 (2H, d, *J* = 7.2 Hz), 3.12 (2H, d, *J* = 7.2 Hz) and 5.17 (2H, m) were due to two prenyl groups. One signal at δ~H~ 2.57 (4H, m) was due to two methylenes. The ^13^C-NMR ([Table 1](#molecules-24-01923-t001){ref-type="table"}), HSQC and DEPT ([Figures S14--S16, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) spectra of **2** displayed 25 carbon signals, including four methyls, one methoxy group, four methylenes and six methines. HMBC correlations showed correlations of H-1′ (δ~H~ 3.19) with C-4 (δ~C~ 143.6), C-5 (δ~C~ 134.3), C-6 (δ~C~ 119.6), C-2′ (δ~C~ 123.5) and C-3′ (δ~C~ 131.0), of H-7 (δ~H~ 2.57) with C-2 (δ~C~ 114.3) and C-6 (δ~C~ 119.6), of H-1′' (δ~H~ 3.12) with C-11 (δ~C~ 155.3), C-13 (δ~C~ 155.3), C-2′' (δ~C~ 123.9) and C-3′' (δ~C~ 129.0), of H-2′' (δ~H~ 5.17) with C-4′' (δ~C~ 17.7) and C-5′' (δ~C~ 25.5)([Figure S17, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}). On the basis of the above inferences, the structure of **2** was identified as 7,8-dihydro-3,11,13-trihydroxy-4-methoxy-5,12-diisopentenylstilbene and named as licostilbene B.

Compound **3** was found to be brown powder. The HR-ESI-MS spectrum of **3** gave a molecular ion peak \[M + H\]^+^ at *m*/*z* 387.1068, consistent with a molecular formula of C~20~H~18~O~8~ ([Figure S21, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}). The configuration at C-2" was identified to be *R* based on its optical rotation value (\[α\]~22\ *D*~ + 0.8, dissolved in methanol) \[[@B19-molecules-24-01923]\]. The UV spectrum of **3** showed absorption maxima at 258 and 369 nm, which indicated that compound **3** had a flavonoid skeleton \[[@B20-molecules-24-01923]\] ([Figure S20, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}).

The ^1^H-NMR spectrum ([Table 2](#molecules-24-01923-t002){ref-type="table"}, [Figure S22, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) of compound **3** showed the presence of four aromatic protons, with two of them at δ~H~ 6.89 (1H, d, *J* = 8.8 Hz) and 7.85 (1H, d, *J* = 8.8 Hz) assignable to a 2′,3′,4′-trihydroxy-substituted B ring of a flavone structure and two additional signals at δ~H~ 7.69 (1H, s) and 6.52 (1 H, s) assignable to the protons on C-3 and C-8 \[[@B21-molecules-24-01923]\]. The signal at δ~H~ 9.44 (3H, br s) was due to three hydroxys connected with C-2′, C-3′ and C-4′. The signals at δ~H~ 1.15 (3H, s) and 1.14 (3H, s) were due to two methoxy groups. The proton resonance at δ~H~ 3.05 (2H, d, *J* = 8.4 Hz) and 4.74 (1H, t, *J* = 8.4 Hz) was due to an oxygenated methine and a methylene. One hydroxy (δ~H~ 12.76) was attached to C-5 (δ 154.8) because of the intramolecular hydrogen bond which increased the chemical shift. The ^13^C-NMR ([Table 2](#molecules-24-01923-t002){ref-type="table"}), HSQC and DEPT ([Figures S23--S25, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) spectra showed 20 carbon signals, with 15 of them assignable to a flavone skeleton and the remaining five carbons at δ~C~ 25.9, 25.0, 25.8, 70.1 and 91.5 assignable to a modified prenyl group.

An --OCH--CH~2~-- spin system was evident in the ^1^H-NMR and ^1^H-^1^H correlation spectroscopy (^1^H-^1^H COSY, [Figure S28, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}). HMBC ([Figure S26, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) supported the correlations between the oxygenated methine and methylene protons of this spin system and the carbon resonances at δ 108.4 and δ 166.2, and thus, the presence of a furan ring was confirmed which is fused to the flavone moiety. The presence of two isolated methyl groups belonging to a hydroxyisopropyl moiety of the furan ring located next to the methine proton was evident from the peaks at δ~H~ 1.14 (3H, s) and 1.16 (3H, s) and carbon signals at δ~C~ 25.0, and 25.9 in ^1^H and ^13^C-NMR spectra. HMBC correlations within the furan ring led to the assigned structure of compound **3**. In addition, HMBC provided support for the existence of a flavoniod skeleton, such as correlations of H-3 (δ~H~ 7.69) with C-2 (δ~C~ 147.8) and C-1′ (δ~C~ 119.9), of H-6′ (δ~H~ 7.54) with C-2 (δ~C~ 147.8), of H-8 (δ~H~ 6.52) with C-6 (δ~C~ 108.4), C-7 (δ~C~ 166.2), C-9 (δ~C~ 156.1) and C-10 (δ~C~ 103.9). Thus, the structure of the new compound **3** was elucidated as (*R*)-7-(2,3,4-trihydroxyphenyl)-4-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrofuro(3,2-g)chromen-5-one and named as licofuranol A.

Compound **4** was obtained as yellow powder. The HR-ESI-MS spectrum of **4** gave a molecular ion peak \[M + H\]^+^ at *m*/*z* 401.1221 consistent with a molecular formula of C~21~H~20~O~8~ ([Figure S30, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}). The configuration at C-2" was identified to be *S* based on its optical rotation value (\[α\]~22\ *D*~ − 2.1, dissolved in methanol) \[[@B19-molecules-24-01923]\]. The UV spectrum of **4** had absorption maxima at 259 and 354 nm ([Figure S29, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}), which suggested that **4** had a flavonoid skeleton.

The ^1^H-NMR spectrum ([Figure S31, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) showed four aromatic protons ([Table 2](#molecules-24-01923-t002){ref-type="table"}). Three proton resonances at δ~H~ 7.55 (1H, d, *J* = 1.6 Hz), δ 7.44 (1H, dd, *J* = 1.6 Hz, 8.4 Hz) and δ~H~ 6.91 (1H, d, *J* = 8.4 Hz) were observed and displayed a typical ABX system of ring B. The signals at δ~H~ 1.15 (3H, s), 1.14 (3H, s), 3.05 (2H, d, *J* = 8.4 Hz) and 4.74 (1H, t, *J* = 8.4 Hz) were due to a modified prenyl group. The signal at δ~H~ 3.78 (3 H, s) was assigned to one methoxy group. The resonance at δ~H~ 6.52 (1 H, s) was assigned to H-8 of the A ring. The ^13^C-NMR ([Table 2](#molecules-24-01923-t002){ref-type="table"}), HSQC and DEPT spectra ([Figures S32--S34, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) showed 21 carbon signals, including a flavone skeleton, a modified prenyl group and one methoxy group.

The structure of compound **4** was very similar to compound **3,** except one proton attached with C-3 and one hydroxy attached with C-2′ were replaced by one methoxy group and one proton, respectively. Two hydroxys were attached to C-3′ and C-4′ according to HMBC ([Figure S35, Supplementary Materials](#app1-molecules-24-01923){ref-type="app"}) correlations of H-2′ (δ~H~ 7.55) and H-5′ (δ~H~ 6.91) with C-1′ (δ~C~ 120.5), C-3′ (δ~C~ 145.3), C-4′ (δ~C~ 148.7) and C-3′ (δ~C~ 145.3), C-4′ (δ~C~ 148.7), C-6′ (δ~C~ 120.8), respectively. The methoxy group was attached to C-3 due to the correlation of δ 3.78~H~ (-OCH~3~) with C-3 (δ~C~ 137.7). On the basis of the above analysis, the structure of **4** was (*S*)-7-(3, 4-dihydroxyphenyl)-4-hydroxy-3-methoxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrofuro(3,2-g)chromen-5-one, name as licofuranol B.

The known compounds **5**--**12** were identified as α,α′-dihydro-3,5,4′-trihydroxy-4,5′-diisopentenylstilbene (**5**) \[[@B22-molecules-24-01923]\], glycypytilbene B (**6**) \[[@B23-molecules-24-01923]\], luteolin (**7**) \[[@B24-molecules-24-01923]\], quercetin-3,4′-dimethyl ether (**8**) \[[@B25-molecules-24-01923]\], calycosin (**9**) \[[@B26-molecules-24-01923]\], scopoletin (**10**) \[[@B27-molecules-24-01923]\], diosmetin (**11**) \[[@B28-molecules-24-01923]\] and echinatin (**12**) \[[@B29-molecules-24-01923]\], comparing their spectral information with published data in the literature.

2.2. Assessment of Compounds ***1***--***9*** on Cellular Viability. {#sec2dot2-molecules-24-01923}
--------------------------------------------------------------------

To assess the cell viability of compounds **1**--**9**, RAW264.7 cells were exposed to different concentrations of these compounds. The control group was treated with DMSO. As a result, incubation of cells with **1**--**9** for 24 h exerted no significant influence on cell viability ([Figure 2](#molecules-24-01923-f002){ref-type="fig"}).

2.3. Anti-Inflammatory Activity {#sec2dot3-molecules-24-01923}
-------------------------------

It has been reported that the extract of licorice suppresses LPS-induced inflammatory response in murine macrophage and increased the survival rate in LPS-induced mice macrophages \[[@B30-molecules-24-01923]\]. In this work, the anti-inflammatory activity of compounds was evaluated in RAW264.7 cells with inflammation induced by LPS. Compounds **1**--**9** were tested for their NO inhibitory activities in the process of inflammation, and quercetin was used as a positive control. The anti-inflammatory activity of compounds **1**--**9** is shown in [Table 3](#molecules-24-01923-t003){ref-type="table"}. As a result, four new compounds (**1**--**4**) and five known compounds (**5**--**9**) showed stronger anti-inflammatory activities than the positive control quercetin by inducing NO production on LPS-induced RAW264.7 cells.

3. Experimental {#sec3-molecules-24-01923}
===============

3.1. Materials and Methods {#sec3dot1-molecules-24-01923}
--------------------------

### 3.1.1. Plant Materials {#sec3dot1dot1-molecules-24-01923}

Fresh leaves of *Glycyrrhiza uralensis* were collected from Minqin County, Gansu Province, People's Republic of China, in September 2017. The plant was identified by one of the authors, Zhigang Yang, as the voucher specimen (No. MQG201610).

### 3.1.2. Chemicals and Instruments {#sec3dot1dot2-molecules-24-01923}

Sephadex LH-20 was purchased from GE Healthcare Bio-Sciences AB (Uppsala, Sweden). The silica gel for column chromatography and thin-layer chromatography was obtained from Qingdao Marine Chemical Company (Qingdao, China). Open column chromatography was also performed using ODS-C~18~ (Cosmosil 75 C~18~-OPN). The semipreparative HPLC system was carried out on an easysep-1050 system equipped with a single-wavelength detector which was purchased from Unimicro Technologies Co., Lid (Shanghai, China), and a Waters C18 column. ^1^H-NMR, ^13^C-NMR, and 2D-NMR spectra were obtained on a Bruker AVANCE AV III-400 spectrometer (Karlsruhe, BW, Germany). HR-ESI-MS was run on an Agilent LCxLC-IM-QTOF-MS (1290 × 1290 − 6560) spectrometer (Palo Alto, CA, USA). Optical rotations were recorded on a Perkin-Elmer 341 polarimeter. UV spectra were obtained with a UV/visible spectrophotometer (Perkin-Elmer, Waltham, MA, USA).

3.2. Extraction and Isolation {#sec3dot2-molecules-24-01923}
-----------------------------

Leaves of *Glycyrrhiza uralensis* were dried in the shade. Extraction was performed by maceration of dried leaves (8 kg) in 80% methanol (80 L) at room temperature in a conical flask. This process was repeated 3 times and the final extract was filtered. The extract was concentrated under vacuum at 40 °C on a rotary evaporator (IKA^®^-Werke GmbH & Co.KG, Freiburg, BW, Germany). Then, all of the extract (1196.5 g) was dissolved in water and mixed with trichloromethane, ethyl acetate and n-butyl alcohol in a separating funnel to obtain four layers. The ethyl acetate layer was subjected to silica gel (100--200 mesh) column chromatography by successive elution with different proportions of petroleum ether/ethyl acetate (100:0--0:100). The extract was separated into 9 fractions (fr.A-I) according to TLC spots.

Fr.G (10.88 g) was separated by a reverse phase silica gel column with different proportions of methanol/water (20:80--100:1) to obtain 8 fractions (fr.G1-G8). Fr. G2 was further purified by semipreparative HPLC (MeOH/H~2~O, 70:30) to obtain scopoletin (**10**, 2.0 mg). Fr.G4 and Fr.G5 were subjected to silica gel column chromatography to obtain fr.G4A-H and fr.G5A-G, respectively. Fr.G4E was further purified by semipreparative HPLC (MeOH/H~2~O 53:47) to obtain calycosin (**9**, 6.7 mg) and echinatin (**12**, 4.6 mg).

Luteolin (**7**, 5.1 mg) was obtained from fr.G4F by semipreparative HPLC (MeOH/H~2~O 58:42). Fr.G5C was also further purified by semipreparative HPLC (MeOH/H~2~O 58:42) to obtain diosmetin (**11**, 7.9 mg) and quercetin-3,4′-dimethyl ether (**8**, 4.2 mg). Fr.G5E was applied to the silica gel column and eluted with CH~2~Cl~2~/MeOH to obtain 4 fractions (fr.G5E1-4). The semipreparative HPLC of fr.G5E2 (MeOH/H~2~O 60:40) led to licofuranol A (**3**, 26.5 mg) and licofuranol B (**4**, 15.8 mg).

Fraction D (1.85 g) was fractionated on a silica gel column to obtain 6 fractions (fr. D1-6). fr.D5 was separated by silica gel chromatography and successively eluted with petroleum ether/acetone(100:0-0:100) to obtain 8 fractions (sub-fr.D5A--H). D5G was further purified by silica gel column chromatography (MeOH/H~2~O 75:25) to give four compounds including licostilbene A (**1,** 18.5 mg), licostilbene B (**2**, 8.9 mg), α,α′-dihydro-3,5,4′-trihydroxy-4,5′-diisopentenylstilbene (**5,** 12.6 mg) and glycypytilbene B (**6**, 28.4 mg).

3.3. Anti-Inflammatory Activity {#sec3dot3-molecules-24-01923}
-------------------------------

### 3.3.1. Cell Culture {#sec3dot3dot1-molecules-24-01923}

The RAW264.7 macrophage cell line was obtained from the National Infrastructure of Cell Line Resource, maintained in Dulbecco's modified Eagle medium (DMEM, 10% fetal bovine serum, 1% penicillin and streptomycin) and grown at 37 °C in a humidified incubator containing 5% CO~2~. DMEM was changed every two days and cells were subcultured when 80--90% confluency was reached.

### 3.3.2. MTT Assay {#sec3dot3dot2-molecules-24-01923}

The viability of RAW264.7 cells in the presence of different concentrations of compounds (**1**, **3**, **5** μg/mL, dissolved in DMSO) was evaluated by MTT assay. Briefly, the cells (1 × 10^5^ cells/mL) were seeded into a 96-well plate. After 12 h incubation, compounds **1**--**9** with different concentrations were added into the wells and incubated for 24 h. Following incubation, the medium was removed, and 20 μL of MTT (5 mg/mL) was added into the wells and incubated for another 4 h. Finally, 150 μL of DMSO was added and the absorbance at 490 nm was determined using a microplate reader.

### 3.3.3. NO Determination {#sec3dot3dot3-molecules-24-01923}

RAW264.7 cells were seeded at 1 × 10^6^/mL in 96-well culture plates for NO. Nitrite (NO~2~^−^) in the culture medium was measured as an indicator of NO production using the Griess reaction. All of the operation was according to the NO kit instructions. Briefly, the cells were separated into four groups: treated with DMSO (negative control), LPS (1 μg/mL, model), LPS + quercetin (5 μg/mL, positive control) and LPS + compounds with different concentrations (treatment group). All the agents were added at the same time, and the groups were treated for 24 h. After treatment with various concentrations of compounds and quercetin, the supernatant of cells was mixed with an equal volume of Griess reagent, and the absorbance of the mixture was measured at 540 nm. The experiments were repeated three times independently.

4. Conclusions {#sec4-molecules-24-01923}
==============

In this work, 12 compounds, including four new structures (**1**--**4**), were isolated and identified from leaves of *G. uralensis*. Among these compounds, **1**--**9** showed significant NO inhibitory activities on LPS-induced RAW264.7 cells. Four bioactive compounds, licostilbene A--B (**1**--**2**) and licofuranol A--B (**3**--**4**), were observed for the first time. We hope that these active compounds will be useful for the prevention and treatment of inflammation.

The authors are thankful to the Analysis and Test Center, Lanzhou University; Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences.

**Sample Availability**: Samples of the compounds are available from the authors.

The following data are available online: component percentages of compound **1**--**12** (Table S1), UV, HR-ESI-MS, 1D- and 2D-NMR spectra of compounds **1**--**9** (Figures S1--S42).

######

Click here for additional data file.

Z.Y. conceived and designed the experiments. L.W. conducted the purification of the compounds and the structure elucidation. K.Z. and H.B. conducted and analyzed the HRESIMS analysis. L.Z. conducted and analyzed the UV analysis. S.H. and H.D. evaluated the anti-inflammatory activity of pure compounds. H.B., L.W., Y.Z. and J.W. collected the plant material. F.B. provided helps in the procedure of isolation. L.W., Z.Y., Y.L., K.Z. and L.Z. shared the processes of analyzing the data and writing the manuscript.

This work was supported by the grant from the Major International S & T Cooperation Project, Ministry of Science and Technology of the People's Republic of China (2016YFE0129000; 2017YFC1701400; SQ2017YFC170424); Research project of Gansu Provincial Administration of Traditional Chinese Medicine (GZK-2015-21); the Key Program for International S&T Cooperation Projects of Gansu Province (18YF1WA115); and the Fundamental Research Funds for the Central Universities (lzujbky-2017-k26).

The authors declare no conflict of interest.

![Structures of compounds **1**--**12** from *G. uralensis.*](molecules-24-01923-g001){#molecules-24-01923-f001}

![The cellular viabilities of RAW264.7 cells treated with compounds **1**--**9**. All the data are expressed as means ± SD of three independent experiments.](molecules-24-01923-g002){#molecules-24-01923-f002}

molecules-24-01923-t001_Table 1

######

^1^H- and ^13^C-NMR spectroscopic data of compounds **1**, **2** and **5** (400 MHz for ^1^H-NMR and 100 MHz for ^13^C-NMR, in DMSO-*d*~6~, *δ* in ppm, *J* in Hz).

  Position   1                            2       5
  ---------- ---------------------------- ------- ---------------------------- ------- -------------------------------- -------
  1          \-                           135.0   \-                           137.1   \-                               131.8
  2          6.58 (1H, s)                 114.5   6.54 (1H, d, *J* = 1.6 Hz)   114.3   6.82 (1H, d, *J* = 2 Hz)         129.2
  3          \-                           149.7   \-                           149.7   \-                               127.1
  4          \-                           143.7   \-                           143.6   \-                               152.9
  5          \-                           134.3   \-                           134.3   6.67 (1H, d, *J* = 8.8 Hz)       114.7
  6          6.43 (1H, d, *J* = 1.6 Hz)   119.8   6.40 (1H, d, *J* = 1.6 Hz)   119.6   6.80 (1H, dd, *J* = 8.8, 2 Hz)   126.2
  7          2.73 (2H, m)                 35.7    2.57 (2H, m)                 36.5    2.62 (2H, m)                     36.4
  8          2.93 (2H, m)                 34.6    2.57 (2H, m)                 37.1    2.54 (2H, m)                     37.6
  9          \--                          136.9   \-                           139.6   \-                               139.7
  10         \-                           118.6   6.13 (1H, s)                 106.2   6.12 (1H, s)                     106.3
  11         \-                           155.4   \-                           155.7   \-                               155.7
  12         6.75 (1H, d, *J* = 0.8 Hz)   95.4    \-                           111.7   \-                               111.7
  13         \-                           155.4   \-                           155.7   \-                               155.7
  14         6.58 (1H, s)                 111.7   6.13 (1H, s)                 106.2   6.12 (1H, s)                     106.3
  1′         3.18 (2H, d, *J* = 7.2 Hz)   28.3    3.19 (2H, d, *J* = 7.2 Hz)   28.3    3.16 (2H, d, *J* = 7.2 Hz)       28.2
  2′         5.16 (1H, t, *J* = 7.2 Hz)   123.5   5.17 (1H, m)                 123.5   5.24 (1H, t, *J* = 7.2Hz)        123.1
  3′         \-                           130.9   \-                           131.0   \-                               130.9
  4′         1.66 (3H, s)                 17.7    1.67 (3H, s)                 17.7    1.65 (3H, s)                     17.7
  5′         1.66 (3H, s)                 25.5    1.67 (3H, s)                 25.5    1.67 (3H, s)                     25.5
  1′′        6.83 (1H, d, *J* = 2.0 Hz)   105.1   3.12 (2H, d, *J* = 6.8 Hz)   21.9    3.12 (2H, d, *J* = 6.8 Hz)       21.9
  2′′        7.71 (1H, d, *J* = 2.0 Hz)   143.4   5.17 (1H, m)                 123.9   5.15 (1H, t, *J* = 6.8 Hz)       123.9
  3′′        \-                           \-      \-                           129.0   \-                               129.0
  4′′        \-                           \-      1.59 (3H, s)                 17.7    1.59 (3H, s)                     17.7
  5′′        \-                           \-      1.68 (3H, s)                 25.5    1.68 (3H, s)                     25.5
  4-OCH~3~   3.64 (3H, s)                 59.6    3.64 (3H, s)                 59.6

molecules-24-01923-t002_Table 2

######

^1^H- and ^13^C-NMR spectroscopic data of compounds **3**--**4** (400 MHz for ^1^H-NMR and 100 MHz for ^13^C-NMR, in DMSO-*d*~6~, *δ* in ppm, *J* in Hz)**.**

  Position   3                            4
  ---------- ---------------------------- ----------- ---------------------------------- -----------
  2          \-                           147.8       \-                                 155.6
  3          7.69 (1H, s)                 115.6       \-                                 137.7
  4          \-                           176.0       \-                                 178.1
  5          \-                           154.8       \-                                 155.3
  6          \-                           108.4       \-                                 108.8
  7          \-                           166.2       \-                                 166.3
  8          6.52 (1H, s)                 88.4        6.52 (1H, s)                       88.6
  9          \-                           156.1       \-                                 156.3
  10         \-                           103.9       \-                                 105.1
  1′         \-                           119.9       \-                                 120.5
  2′         \-                           146.9       7.55 (1H, d, *J* = 1.6 Hz)         115.5
  3′         \-                           135.8       \-                                 145.3
  4′         \-                           145.1       \-                                 148.8
  5′         6.88 (1H, d, *J* = 8.8 Hz)   115.2       6.91 (1H, d, *J* = 8.4 Hz)         115.7
  6′         7.54 (1H, d, *J* = 8.8 Hz)   122.0       7.44 (1H, dd, *J* = 1.6, 8.4 Hz)   120.8
  1′′        3.06 (2H, d, *J* = 8.4 Hz)   25.8        3.05 (2H, d, *J* = 8.4 Hz)         25.8
  2′′        4.73 (1H, t, *J* = 8. 4Hz)   91.5        4.74 (1H, t, *J* = 8.4 Hz)         91.6
  3′′        \-                           70.1        \-                                 70.1
  4′′,5′′    1.16, 1.14 (6H, d)           25.0,25.9   1.15, 1.14 (6H, d)                 24.9,25.9
  3-OCH3     \-                           \-          3.78 (3H, s)                       59.7
  5-OH       12.76 (1H, s)                \-          12.92 (1H, s)                      \-

molecules-24-01923-t003_Table 3

######

Effect of compounds **1**--**9** on NO production stimulated by LPS in RAW264.7 cells.

  No.         IC~50~ (μg/mL)
  ----------- ----------------
  **1**       2.60
  **2**       2.15
  **3**       3.21
  **4**       3.25
  **5**       2.00
  **6**       3.45
  **7**       2.53
  **8**       3.13
  **9**       3.17
  quercetin   4.08


A Brevard County teenager is in a whole lot of trouble after driving his father's car into a lake early Thursday morning.

The 14-year-old and his girlfriend managed to escape with minor injuries, but now the teen faces some serious charges -- brought on by his own dad.

Only visible by its bumper, a police dive team searched the small lake for a white Dodge Intrepid.

Palm Bay police said the teen stole his father's car and took it on a 3 a.m. joyride with his 18-year-old girlfriend at Palm Bay Regional Park.

That, police said, was when the boy lost control and ended up driving into the lake.

The boy's mother, said she was just relieved that both teens made it out safely.

"It's about 3 to 4 feet right here, where the car first went in," she said. "My son said it went in fast and hard, and the water was filling up on both sides, and it just kept getting deeper."

Water was rushing into vehicle, but the teen's mother said her son had watched a TV show on how to escape such a scenario.

"He was able to pull himself and his friend out of the vehicle as it was sinking in the water," she said. "He was able to pull a door open after a lot of struggling with it, and pull her across and pull them both out as the car was sinking."

Inside the car, police found some fish and the boy’s hat.

The vehicle was deemed a total loss, and so was everything inside, including hundreds of dollars' worth of computer equipment that belonged to the teen's father.

Now, the father, is pressing charges against his own son.

"Right now we're looking at a stolen vehicle, so grand theft," said Palm Bay police Sgt. Jesse Eakins. "He was on home detention, so you're looking at violating his probation. Plus, we have several traffic charges we will charge him with. He's definitely getting punished for this joyride."

A hard lesson to learn, but his parents said they hope it will help him in the long run.

"We're very lucky we're not planning a funeral today, and he's at home resting," the boy's mother said.

After that day of rest Thursday, the 14-year-old's parents said they are bringing their son to a juvenile detention center on Friday.


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from aliyunsdkcore.request import RpcRequest
from aliyunsdkretailcloud.endpoint import endpoint_data

class DeletePersistentVolumeRequest(RpcRequest):

	def __init__(self):
		RpcRequest.__init__(self, 'retailcloud', '2018-03-13', 'DeletePersistentVolume')
		self.set_method('POST')
		if hasattr(self, "endpoint_map"):
			setattr(self, "endpoint_map", endpoint_data.getEndpointMap())
		if hasattr(self, "endpoint_regional"):
			setattr(self, "endpoint_regional", endpoint_data.getEndpointRegional())

	def get_PersistentVolumeName(self):
		return self.get_body_params().get('PersistentVolumeName')

	def set_PersistentVolumeName(self,PersistentVolumeName):
		self.add_body_params('PersistentVolumeName', PersistentVolumeName)

	def get_ClusterInstanceId(self):
		return self.get_body_params().get('ClusterInstanceId')

	def set_ClusterInstanceId(self,ClusterInstanceId):
		self.add_body_params('ClusterInstanceId', ClusterInstanceId)


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Visitors may post reviews, comments, and other content; send e-cards and other communications; and submit suggestions, ideas, comments, questions, recommendations, or other information, so long as the content is not illegal, obscene, threatening, defamatory, invasive of privacy, infringing of intellectual property rights, or otherwise injurious to third parties or objectionable and does not consist of or contain software viruses, political campaigning, commercial solicitation, chain letters, mass mailings, or any form of "spam." You may not use a false e-mail address, impersonate any person or entity, or otherwise mislead as to the origin of a card or other content. anatomicalfigures.com reserves the right (but not the obligation) to remove or edit such content, but does not regularly review posted content.

If you do post content or submit material, and unless we indicate otherwise, you grant anatomicalfigures.com and its affiliates a nonexclusive, royalty-free, perpetual, irrevocable, and fully sublicensable right to use, reproduce, modify, adapt, publish, translate, create derivative works from, distribute, and display such content throughout the world in any media. You grant anatomicalfigures.com and its affiliates and sublicensees the right to use the name that you submit in connection with such content, if they choose. You represent and warrant that you own or otherwise control all of the rights to the content that you post; that the content is accurate; that use of the content you supply does not violate this policy and will not cause injury to any person or entity; and that you will indemnify anatomicalfigures.com or its affiliates for all claims resulting from content you supply. anatomicalfigures.com has the right but not the obligation to monitor and edit or remove any activity or content. anatomicalfigures.com takes no responsibility and assumes no liability for any content posted by you or any third party.

RISK OF LOSS

All items purchased from freedom-of-teach.com are made pursuant to a shipment contract. This means that the risk of loss and title for such items pass to you upon our delivery to the carrier.

PRODUCT DESCRIPTIONS

anatomicalfigures.com and its affiliates attempt to be as accurate as possible. However, anatomicalfigures.com does not warrant that product descriptions or other content of this site is accurate, complete, reliable, current, or error-free. If a product offered by anatomicalfigures.com itself is not as described, your sole remedy is to return it in unused condition.

PRICING

Except where noted otherwise, the List Price displayed for products on our website represents the full retail price listed on the product itself, suggested by the manufacturer or supplier, or estimated in accordance with standard industry practice. The List Price is a comparative price estimate and may or may not represent the prevailing price in every area on any particular day. For certain items that are offered as a set, the List Price may represent "open-stock" prices, which means the aggregate of the manufacturer's estimated or suggested retail price for each of the items included in the set. Where an item is offered for sale by one of our merchants, the List Price may be provided by the merchant.

Despite our best efforts, a small number of the items in our catalog may be mispriced. If we discover a mispricing, we will do one of the following:

If an item's correct price is lower than our stated price, we will charge the lower amount and ship you the item.

If an item's correct price is higher than our stated price, we will, at our discretion, either contact you for instructions before shipping

or cancel your order and notify you of such cancellation.

OTHER BUSINESSES

Parties other than anatomicalfigures.com and its subsidiaries operate stores, provide services, or sell product lines on this site. In addition, we provide links to the sites of affiliated companies, individuals, and certain other businesses. We are not responsible for examining or evaluating, and we do not warrant the offerings of, any of these businesses or individuals or the content of their Web sites. anatomicalfigures.com does not assume any responsibility or liability for the actions, product, and content of all these and any other third parties. You should carefully review their privacy statements and other conditions of use.

DISCLAIMER OF WARRANTIES AND LIMITTATION OF LIABILITY

THIS SITE IS PROVIDED BY ANATOMICALFIGURES.COM ON AN "AS IS" AND "AS AVAILABLE" BASIS. ANATOMICALFIGURES.COM MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, AS TO THE OPERATION OF THIS SITE OR THE INFORMATION, CONTENT, MATERIALS, OR PRODUCTS INCLUDED ON THIS SITE. YOU EXPRESSLY AGREE THAT YOUR USE OF THIS SITE IS AT YOUR SOLE RISK.

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CERTAIN STATE LAWS DO NOT ALLOW LIMITATIONS ON IMPLIED WARRANTIES OR THE EXCLUSION OR LIMITATION OF CERTAIN DAMAGES. IF THESE LAWS APPLY TO YOU, SOME OR ALL OF THE ABOVE DISCLAIMERS, EXCLUSIONS, OR LIMITATIONS MAY NOT APPLY TO YOU, AND YOU MIGHT HAVE ADDITIONAL RIGHTS.

APPLICPLABLE LAW

By visiting anatomicalfigures.com, you agree to the laws, without regard to principles of conflict of laws, that will govern these Conditions of Use and any dispute of any sort that might arise between you and anatomicalfigures.com or its affiliates.

DISPUTES

Any dispute relating in any way to your visit to anatomicalfigures.com or to products you purchase through anatomicalfigures.com shall be submitted to confidential arbitration, except that, to the extent you have in any manner violated or threatened to violate anatomicalfigures.com intellectual property rights, anatomicalfigures.com may seek injunctive or other appropriate relief in any state or federal court , and you consent to exclusive jurisdiction and venue in such courts. Arbitration under this agreement shall be conducted under the rules then prevailing of the American Arbitration Association. The arbitrator's award shall be binding and may be entered as a judgment in any court of competent jurisdiction. To the fullest extent permitted by applicable law, no arbitration under this Agreement shall be joined to an arbitration involving any other party subject to this Agreement, whether through class arbitration proceedings or otherwise.

SITE POLICIES, MODIFICATION, AND SEVERABILITY

Please review our other policies, such as our pricing policy, posted on this site. These policies also govern your visit to anatomicalfigures.com. We reserve the right to make changes to our site, policies, and these Conditions of Use at any time. If any of these conditions shall be deemed invalid, void, or for any reason unenforceable, that condition shall be deemed severable and shall not affect the validity and enforceability of any remaining condition.


Wisconsin Rapids School Districthttp://sped.dpi.wi.gov/taxonomy/term/2339/all
enIDEA Complaint Decision 12-037http://sped.dpi.wi.gov/ideacomplaint_12-037

On July 9, 2012 (letter dated July 3, 2012), the Department of Public Instruction (DPI) received a complaint under state and federal special education law from XXXXX against the Wisconsin Rapids School District. This is the departments decision regarding that complaint. The issues are whether the district, during the 2011-12 school year, properly implemented the students individualized education program (IEP) regarding the provision of additional time to complete assignments and assistance with organization, and properly revised the students IEP.

Tue, 16 Oct 2012 20:44:13 +0000DPI Web Administrator26063 at http://sped.dpi.wi.govIDEA Complaint Decision 10-077 http://sped.dpi.wi.gov/ideacomplaint_10-077

On December 9, 2010, the Department of Public Instruction received a complaint under state and federal special education law from XXXXX against the Wisconsin Rapids School District. This is the departments decision regarding that complaint. The issues are whether the district properly conducted a special education evaluation in the spring of 2010 and properly responded to a request for a special education evaluation in the fall of 2010.

Thu, 01 Jan 1970 00:00:01 +0000James Verbick24878 at http://sped.dpi.wi.govIDEA Complaint Decision 09-020 http://sped.dpi.wi.gov/ideacomplaint_09-020

On March 23, 2009 (form dated March 22, 2009), the Department of Public Instruction (DPI) received a complaint under state and federal special education law from XXXXX against the Wisconsin Rapids School District. This is the departments decision regarding the complaint. The issues are whether the district, during the 2008-2009 school year, utilized a properly licensed teacher, properly informed staff of their responsibility for implementing the students individualized education program (IEP), and properly addressed the annual goals.

Thu, 01 Jan 1970 00:00:01 +0000James Verbick25011 at http://sped.dpi.wi.govIDEA Complaint Decision 07-037http://sped.dpi.wi.gov/ideacomplaint_07-037

On April 17, 2007, the Department of Public Instruction received a complaint under state and federal special education law from XXXXX against the Wisconsin Rapids School District. This is the departments decision regarding that complaint. The issues are whether the district, during the 2006-2007 school year:

Thu, 01 Jan 1970 00:00:01 +0000James Verbick25433 at http://sped.dpi.wi.govIDEA Complaint Decision 06-038http://sped.dpi.wi.gov/ideacomplaint_06-038

On August 8, 2006 (letter dated July 15), the Department of Public Instruction received a complaint under state and federal special education law from XXXXX against the Wisconsin Rapids School District. This is the departments decision regarding that complaint.

Thu, 01 Jan 1970 00:00:01 +0000James Verbick25516 at http://sped.dpi.wi.gov


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