The present invention relates to a method for producing o-alkoxybenzoic acid. More specifically, the present invention relates to a method for producing o-monoalkoxybenzoic acid or o-dialkoxybenzoic acid, being useful as intermediates for pharmaceutical agents, agricultural chemicals, dyes, fragrances and the like and useful as functional pharmaceutical agents such as a second pharmaceutical solution for dental cement, components of adhesive agents and the like.
The following methods have conventionally been known as techniques for producing o-monoalkoxybenzoic acid as an o-alkoxybenzoic acid;
1. A method represented by a reaction formula (1) ##STR1## (wherein R represents a methyl-, ethyl-, propyl-, butyl-, n-pentyl-, n-hexyl- or n-octyl group; and X represents bromine, chlorine or iodine), comprising adding alkyl halide to an aqueous potassium hydroxide solution of o-hydroxybenzoic acid with 18-crown-6 added as a catalyst, and reacting them together [Zh. Org. Khim. 23(3), 667-668 (1987)];
2. A method represented by a reaction formula (2) ##STR2## comprising adding alkyl bromide to a potassium carbonate solution of methyl o-hydroxybenzoate and reacting them together under reflux [Azerb. Khim. Zh., (2) 46-49 (1987)];
The following two methods are known as techniques for producing 2,6-dialkoxybenzoic acid;
3. A method represented by a reaction formula (3) ##STR3## comprising effecting a Kolbe Schmitt reaction using resorcin as a starting material, methylating the reaction product with dimethyl sulfate, and further processing the product in an aqueous dilute sodium hydroxide solution at a higher temperature (Specifications of Hungarian Patent Nos. 162,756 and 162,757).
4. A method represented by a reaction formula (4) ##STR4## comprising metallation with metal potassium using 1,3-dimethoxybenzene as a starting material, and subsequently making the resulting product coexist with a base such as TMEDA (N,N,N,N-tetramethyl-1,2-ethylene diamine) (Specifications of U.S. Pat. Nos. 4,845,276 and 4,845,277; Japanese Patent Laid-open Nos. 2-108650 and 2-108651).
However, the method described in (1) is industrially disadvantageous in that a mixed product of o-alkoxybenzoic acid alkyl ester and o-alkoxybenzoic acid is obtained at a ratio of 3:2, and additionally in that the 18-crown-6 to be used as a catalyst is extremely expensive. The method described in (2) is not suitable industrially, because costly alkyl bromide must be used for the reaction and o-alkoxybenzoic acid methyl ester must be subjected to another step for hydrolysis.
The method described in (3) cannot be considered advantageous for industrial practice. The method employs potassium salt and carbon dioxide gas and involves a Kolbe Schmitt reaction under high temperature and high pressure conditions. In addition, a side reaction of the positional isomer via resorcin occurs, resulting in an extremely low yield of objective product, 2,6-dimethoxybenzoic acid, so that improvement of increase in yield is difficult. According to the reaction described in (4), a problem concerning selectivity can be avoided and the yield of the objective product gets higher. An Italian publication [Gazzetta Chimica Italiano, 111, 123 (1981)] describes that, if the starting material is a 1,3-dialkylbenzene other than 1,3-dimethoxybenzene, such as 1,3-diisopropylbenzene or 1-propoxy-3-methoxybenzene, the yield and selectivity are both poor because of the positional isomer of byproducts, so it is not preferable method for an industrial reaction.


Regional Pro Series

Regional Pro Series is a professional cricket league in Scotland. The series was first contested in 2016 replaced the North Sea Pro Series a competition which was a joint venture between the Royal Dutch Cricket Board and Cricket Scotland. The Regional Pro Series comprises a 50-over tournament, the CS Pro50 Cup and a 20-over tournament the CS T20 Blitz.

The tournament consists of three teams; Western Warriors, Eastern Knights and Caledonian Highlanders. Each team is based in a different region of Scotland and has representative teams throughout youth age groups. Eastern Knights are the defending champion in both 50 over and T20 competitions.

Teams

Squads (2019)

See also

 Cricket in Scotland
 Scottish National Cricket League
 Murgitroyd T20
 North Sea Pro Series
 Strathmore & Perthshire Cricket Union
 Strathmore Union

References

External links

Regional Pro Series, Cricket Scotland

Category:Scottish domestic cricket competitions
Category:2016 establishments in Scotland
Category:2016 in Scottish cricket
Category:Recurring sporting events established in 2016
Category:Sports competitions in Scotland


Eclipse has the highest single strength juice and varietal content of any Winexpert wine kit, past or present. Added grape skins on most of the red wines as well as changes in oak and yeast processes on some styles ensures Eclipse wines are comparable to commercial wines, delivering outstanding varietal character, structure and intensity of flavor. Bottle labels included in each wine kit as well as varietal style sticker with concise wine descriptors. 18 liter kits make 6 gallons.


How Much are Hidden Currency Exchange Fees Costing You? (Infographic)

When you send money to another country, you’re not always sending as much as you think.

Let me show you some of the different fees that are being taken from you as you send money across the globe using services like PayPal.

The cheapest legitimate transfer method on PayPal is “Mass Pay”. This is an easy way to pay several people at once by uploading a CSV spreadsheet of all the payment amounts. The cost is usually 2% to a maximum of $20 for offshore payments.

There are also global payments that PayPal charges for their currency conversion fee which is actually a hidden fee. We have found that this fee comes out to be about 2.5% of the money sent.

And finally, there may be additional fees that banks are charging your employees to withdraw the money from PayPal and transferring it to their personal bank accounts.

But this infographic isn’t just about PayPal.

Almost all services that you use to transfer money to your employees have hidden fees attached to it. We’ve essentially broken down the infographic into two parts.

In the top half, we’ve created a hypothetical scenario in which you send $5,000 to employees to the Phillipines. We break down how much airports, banks, credit cards, Western Union, PayPal, Moneygram, and Ria Money Transfer extract from you.

In the bottom half, we show you some of the higher exchange fees we’ve seen across multiple countries and payment platforms. (Note: These fees are once again based on transferring $5,000.)


Threaded View

Scary looking kitty fight here: Normal behavior?

You know, most of the time my girls are great friends, but sometimes they chase each other and wrestle; no big deal actually. Usually it's Lily who goes after Luna.

Tonight, I heard Luna hissing, and when I looked, I saw them on the floor, Lily on Luna's back with her arms around her, and her teeth were in the left side of her neck! Obviously Luna was in pain, because she hissed again, before she came free. She's obviously not hurt (she has a thick fur), but it looked scary what Lily did. And I think it's not the first time she did that, because I heard Luna hissing before, and sometimes I find fur on the floor.

What do you think about this? Is this neck biting thing still a normal behavior to test and train their skills, or is it a sign of aggression/domination?


Off-road vehicles are commonly equipped with endless tracks rather than tires. Tracks have been found to be more useful than tires in rough or marshy terrain, in that they are less prone to stress-induced failures and to becoming bogged down. Tracks are desirable because they spread their load (several thousand pounds for large agricultural power drives) over a larger surface area than do tires for similar loads, so that the tracked vehicles do not sink into the ground. For this reason, tracked power drive vehicles have become widespread in off-road applications such as construction, the military, recreational vehicles, snow grooming, and some tracked vehicles have been used in agricultural harvesting. See, for example, U.S. Pat. No. 5,176,573 issued to Paul Dow on Jan. 5, 1993.
Tracked vehicles commonly employ endless linked steel belts as tracks. These steel tracks are usually cleated on the outside to improve traction. Steering is commonly accomplished by immobilizing one of the tracks and driving the other, causing the vehicle to pivot on its stationary track. This maneuver requires high horsepower and also does significant damage to the surface beneath the vehicle. Therefore, steel-tracked vehicles are generally prohibited on paved roadways and must be transported over the road on flatbed trucks.
Agricultural harvesters are used in plowed fields and even during wet weather; then, tracks are superior to tires for traction. An added advantage of tracks is that they do less damage to the soil by way of compaction and rutting. Recently, tracks made of elastomeric materials such as rubber or plastic have become available as alternatives to steel tracks. In agricultural harvesting, for example, rubber tracked vehicles can be driven in the fields without significant damage to the soil and then be driven over paved roads from field to field. It is a feature of the invention to provide improved tracked vehicles which can travel over the road, and at reasonable speeds.
Tracked vehicles are known to be powered hydraulically, as disclosed in, for example, U.S. Pat. No. 3,447,619. A common drive utilizes a low-speed high-torque (LSHT) hydraulic motor. Such drives are powerful but are incapable of road speeds above about 15 miles per hour, whereas many portions of the harvesting industry depend upon a road speed of 20 miles per hour or higher to meet the demands of the harvesting schedule. Other drives use high-speed hydraulic motors with gear reduction, but these are bulky, costly, and subject to high maintenance.
A common means of driving a rubber track is by forming a drive wheel within the power unit as essentially a sprocket and engaging the teeth of the sprocket with holes formed in the track. This design has the drawback that the sprocket teeth protrude through the rubber track and can dig up the field and, more seriously, do damage to paved roadway.
Off-road tracked vehicles must handle rough, rocky terrain without conventional ride-softening suspension elements such as springs and shock-absorbers, which would interfere with precise location of the picking and threshing mechanisms with respect to the crop and with respect to each other. Track designs which have heretofore been proposed include designs which ride very roughly over objects in their path. The track assembly must ride up on the object, reach its balance point, and then fall forward, with no means within the action of the track to absorb the shock of encountering the obstacle.
A drawback of conventional two-track vehicles resides in the long length of track required to support the vehicle. This exacerbates the aforementioned steering difficulty and surface damage. While four-track vehicles having a two-part articulated chassis have been proposed, for example, in U.S. Pat. Nos. 3,435,908; 3,741,331; 3,789,942; 3,937,289; and 4,072,203, they have not been suitable for heavy loads as required for agricultural harvesting applications. It is a feature of the invention to provide improved power drives which enable four-track vehicles to haul heavy loads over rough terrain and with positional stability needed to locate harvesting heads and threshing components with respect to the ground and to each other.
An additional drawback of conventional four-track vehicles is the need to limit the freedom of articulation of the joint between front and rear elements to left and right horizontally. This limits the ability of the vehicle to adapt to irregular terrain. This is because vertical rigidity must be maintained between the two elements, particularly in designs in which independent vertical oscillation of each of the four power units is permitted. Without vertical rigidity, the articulating joint is vertically unstable in such conventional two-track vehicles. For this reason, a simple ball-joint connection cannot be used. It is a feature of the invention to provide a joint for an articulated tracked vehicle which permits both horizontal (left and right) and rotational (about a longitudinal axis through the rear element) relative motion of the front and rear elements, while maintaining vertical rigidity between the elements.
Track drive units commonly are designed with rugged drive elements such as sprockets and chains which are exposed for easy repair and maintenance, which has the drawback of making these elements vulnerable to damage. It is a feature of this invention to provide a power unit for a tracked vehicle wherein the drive elements are encased and located, within the unit for maximum protection of the elements, but in a way which does not interfere with operation and which still permits ready access for repairs and maintenance.


MILWAUKEE -- The City of Milwaukee is the focus of a federal lawsuit, with six sex offenders suing the city.

They're suing over the 2,000-foot buffer zone around schools, parks, playgrounds, day cares and other places children can be found.

Milwaukee's sex offender ordinance says they cannot live in those areas.

For a year, FOX6 News has been spotlighting concerns about the 2,000-foot ban. There are only a few dozen addresses in Milwaukee where sex offenders can live, and most of them are single-family homes that aren't for sale or rent.

The lawsuit says the ordinance amounts to banishment, which is against the constitution. It claims some of the offenders are homeless as a result, and others are being forced to live in compromised situations.

The attorneys who filed the lawsuit are the same ones who just won a similar federal lawsuit against the Village of Pleasant Prairie.

Milwaukee sex offender residency ordinance


Rainer Werner Fassbinder Tony Rayns - Essay

Tony Rayns

The most striking difference between [The Merchant of Four Seasons] and earlier Fassbinder movies is the immense gain in simplicity and clarity, qualities about which there is nothing deceptive. As the chronicle of a man whose dreams and aspirations are systematically denied him by his petit bourgeois environment, Merchant could hardly be more straightforward: its linear narrative … is a step-by-loaded-step catalogue of the betrayals and humiliations that Hans suffers, while occasional fragmentary, dream-like flashbacks serve to expose the roots of his oppression. The other main change is the nature of the mise en scène; the Godardian unpredictability and genre permutations of the earlier films...


How to Use FMEA to Risk Assess Pathogen Testing Methods

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A Certificate of Analysis (COA) can provide a company with a level of confidence in the quality and purity of its product. However, the company should be able to take the document and understand how the results were gathered, says Maureen Harte, President and CEO at HartePro Consulting, and Lean Six Sigma Master Black Belt. Using Failure Modes and Effects Analysis (FMEA) can help a company identify, quantify and assess risks associated with pathogen detection methods, and should be integrated into a HACCP strategy.

Food Safety Tech: What are the challenges a company faces when assessing results on a Certificate of Analysis (COA)?

Maureen Harte: [Companies] lack the background information to really understand what goes into a COA, and they trust that what is coming to them is the highest quality.

FST: What questions should a company ask?

Harte: They need to consider everything that goes into the testing method itself.

• What is the origin of the COA? • Who’s doing the testing? • What’s the complexity of the method? • What is the overall quality of the method? • How traceable is it? • How well can I trust that this result is the true result (are there false negatives)?

FST: How is FMEA used to evaluate pathogen testing methods?

Harte: FMEA helps us understand the differences between testing methods by individually identifying the risks associated with each method on its own. For each process step [in a test method], we ask: Where could it go wrong, and where could an error or failure mode occur? Then we put it down on paper and understand each failure mode.

For example, most methods have an incubation step. A simple failure mode would be that the incubator isn’t at the correct temperature, or that it has been incubated too long or not long enough. You go across the board for each step, identifying potential failures and the severity. Is there potential that we wouldn’t identify the pathogen? If so, what would happen to the customer? You also rate how often it might happen with the test method. What’s the frequency of it? The last thing we rate is detection. With or without controls, how easy would it be for the personnel in the lab to identify or detect that this problem occurred?

We rate these three factors: severity, frequency and detection, and whether we detect [the pathogen] before it goes out to the retailer or consumer. Then we multiply the ratings and come up with a risk priority number (RPN). We add all RPNs for each step and figure out risk, and the potential for error, for each test methodology.

Image courtesy of Roka Bioscience

FST: How does using FMEA integrate into a HACCP strategy?

Harte: It could be integrated into the HACCP strategy. HACCP deals with identifying potential safety risks, and the key to identifying the risks and proactively trying to eliminating them. That’s what the FMEA is doing as well. I think the integration of FMEA could help identify the critical control points and where the failures will occur. That would be the most streamlined approach.

Harte’s Tips

• Don’t fully trust the COA unless you understand what the result means. • Get involved with the labs that are providing the testing to ensure you have the most comprehensive information surrounding the COA.

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About The Author

Maria Fontanazza has more than 15 years of experience in journalism, marketing, and communications within the medical device industry. She was previously marketing communications manager and market research manager at Secant Medical, Inc., a manufacturer of biomedical textiles and advanced biomaterials. Fontanazza also served as an editor at MD+DI and has authored articles that have appeared in domestic and international industry publications. Fontanazza has a B.A. in Journalism and Mass Communications with a concentration in New Media and Visual Design, and a Minor in Fine Arts, from St. Michael’s College in Colchester, VT. Follow her industry insights on Twitter at @MariaFontanazza. Contact Maria

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Course Objectives: To provide an understanding of the HPP technology and its applications in food processing, including equipment engineering and maintenance, considerations in designing validation and challenge studies for microbial inactivation, and commercialization case studies.

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Thailand Bomb Attacks The Work Of ‘At Least’ 20 People: Police

No group has claimed responsibility for the August 11 and August 12 attacks

BANGKOK: Thai police on Monday said at least 20 people were involved in carrying out a wave of deadly bombings in the country’s south earlier this month.

National police chief Jakthip Chaijinda said that police have not ruled out any motive for the attacks and believe that many of those involved came from Thailand’s Muslim-majority southern provinces.

“We know where they came from, where they went. We believe there are at least 20 people involved in this network,” Jakthip told reporters, without giving further details.

No group has claimed responsibility for the August 11 and August 12 attacks which took place in seven provinces and targeted high profile beach towns, killing four people and injuring dozens.

The bombings came days after Thais voted to accept a military-backed constitution in a nation-wide referendum.

Police and the government ruled out any link to foreign militants within hours of the attacks and insisted the perpetrators were home-grown.

Jakthip said that he could not confirm whether the bombings were an extension of an insurgency in the southern provinces that border Malaysia, where Malay-Muslim insurgents are fighting a bloody war that has claimed more than 6,500 lives since 2004.

“We are unwilling to say what their motive is and whether it is related to the referendum, the insurgency or whether they were hired,” Jakthip said.

Last week, Thai Defense Minister Prawit Wongsuwan said the bombings were “definitely not an extension” of the insurgency.

Security experts told Reuters that official denial of involvement by Malay-Muslim insurgents was unsurprising as admitting southern insurgents could be involved would have serious economic and security implications for Thailand.

A Thai military court issued an arrest warrant last week for a then unidentified suspect for attempting to bomb a beach on the tourist island of Phuket.

Police on Friday identified the man as Ahama Lengha from Narathiwat, one of the Muslim-majority provinces, but said he has not yet been taken into custody.


A Winnipeg mother of six is struggling to find a place to live after being evicted from Manitoba Housing over an incident involving her child who set fire to their home last month.

Joni Gabriel's eight-year-old son was playing with a lighter, and accidentally set toilet paper on fire in the bathroom.

Everyone made it out of the home safely, but it led to an eviction notice from Manitoba Housing, for breaching fire safety rules.

"I honestly don't know why he did it, but we've talked to him," said Gabriel.

Since Oct. 7, Gabriel's family — including four boys and two girls ranging in age from three to 16 years old — is staying at Sonrise Village, a family shelter run by the Salvation Army.

Another Manitoba Housing unit is not an option, said Gabriel. She said her applications have been rejected.

"I've been barred," she said.

With social housing not available, and her kids going stir-crazy in the shelter, Gabriel doesn't know where to turn for an affordable place to live.

While her story is exceptional, it's not unique say advocates, who point to the need for more options for families — especially single mothers.

Son struggling

Gabriel says her son involved in the fire has been under a lot of stress and has issues at school, but he's trying to learn from this mistake.

She said he's seeing a psychologist but has not received any formal diagnosis or treatment plan.

"He's really struggling right now getting into fights, and people not wanting him places because he's acting out," Gabriel said.

"He can't focus for five minutes."

In an email to CBC, a spokesperson for Manitoba Housing said if a tenant is responsible for a fire in a Manitoba Housing property, it can choose to not re-house them.

"The decision on whether another unit is offered depends on a number of factors, including the cause of the fire and the tenant's past history with us.

A past history of causing damage, non-compliance with pest treatments, late or non-payment of rent, or any other behaviours that affect the safety and security of other tenants would be considered," the statement said.

'I feel degraded'

Gabriel said staying at the family shelter with her six kids in tow has been stressful.

"There's a lot of rules, like you can't do this you can't do that," she said. "There's a toy room and a TV room there but they don't let kids run in the hallway, so the [kids] pretty much get into trouble a lot, we're always in the room."

Joni Gabriel and her six kids are staying at Salvation Army until they can find a place to live. (Joni Gabriel)

Gabriel said they eat three meals a day but the last meal is served at 4:30 p.m., and said her kids are often left hungry at night.

"I feel degraded" she said. "Recently they started watching me, how much food we take and like, that's not right," she said.

The unit they are staying in has a kitchen and three bedrooms but she said the heat isn't always working properly.

She said two of her kids had to share a bed with her last week, while her boys slept on the floor.

A spokesperson for the Sonrise Village Centre at Salvation Army said the heating issue in Gabriel's room has since been resolved. As for the issues with the kids, the spokesperson adds the shelter does not have child care services, and all kids must be in the care of their parents at all times.

The Salvation Army also said it provides three healthy portioned meals a day, and unlimited fruit for snacks.

'It kind of reminds me of jail': First Nations Family Advocate

Gabriel's case is not unique says Cora Morgan, First Nations Family Advocate with the Assembly of Manitoba Chiefs.

"Housing is a real crisis for a lot of families that we work with," she said.

Morgan said she's worked with many families who need to be set up at the Salvation Army, but it's usually a temporary basis.

She said the shelter is not set up for families with that many kids.

"All the doors are locked, and the walls are all painted the same colour, there's little windows...it's really tight space, and rule based."

"To me it's institutionalized, a locked down facility, so you know it kind of reminds me of jail."

She said there are many single mothers with kids struggling to find affordable housing in Winnipeg.

"And if there is housing available it's not going to fall within your budget," Morgan said.

"There needs to be more options."

Kids could be taken by CFS

Gabriel said she has a public health nurse and a social worker that are trying to help her find a place to live, but she hasn't had any luck finding a suitable home.

She said she constantly worries that her kids will be apprehended by Child and Family Services one day.

"My kids live in fear," Gabriel said, adding she has had to respond to calls by CFS in the past.

Morgan said Gabriel is at risk of having her kids taken into care.

"Absolutely, children are taken if in the view of the child welfare agency is that there isn't enough space," Morgan said.

CFS would want a parent with six children to have at least a four-bedroom home, she said.

"Poverty is a real issue in connection with the child welfare system," Morgan said. "That's one of the biggest challenges with the system is that they will only support families if children are removed, but there's no investments in ensuring families are stabilized."

Morgan said she hears many complaints from families about Manitoba Housing, and she said it's unfortunate that Gabriel was evicted over an accidental fire.

"Children can be unpredictable, accidents do happen."

Too many barriers for single mothers

Joni Gabriel and her six children are staying at Salvation Army, a homeless shelter in Winnipeg, after being evicted from Manitoba Housing in October. She is seen here with her eight-year-old son, who struggles with mental health issues. (John Einarson/CBC)

Gabriel has also struggled with alcohol addiction in the past, but she said she is sober now.

She is also dealing with the stress of losing a loved one earlier this year. Her brother Jon Gabriel was stabbed to death on Selkirk Avenue in Winnipeg on March 16. Winnipeg police said a 22-year-old man has since been arrested and charged in connection with the death.

"I'm still mourning over that," she said, fighting back tears. "But I'm coping, I'm not using like before or drinking, I'm trying to cope with it better now."

Gabriel said she is currently taking a parenting course but said it's still difficult raising her kids alone.

She recently got banned from the Turtle Island Neighbourhood Centre.

Gabriel said she was told by the city-run facility that her kids are not allowed to attend the centre for the next three months because of misbehaviour.

The City of Winnipeg wouldn't comment on the incident citing privacy laws.

"I have so much on my plate right now, and it's hard to find a place and some places won't even take you because your family is bigger," said Gabriel.

She said her focus now is to find housing in the private sector, but she said renting a 4-bedroom home costs anywhere from $1400 to 1500 a month, plus utilities and food.

"That's too much," she said.

Gabriel said she will continue searching with the help of the First Nations Family Advocate office.

"I hope to find something by December."


Q:

click listeners for dynaically added imageview

I have an activity in my app which displays rss feeds and next to each rss feed arrow image is attached.
I am new to android any help will be appreciated.
i shall explain what i am doing to display rss news ...
i have a seperate dummy xml layout for a single rss.. i have set id for arrow image (which will navigate to the next activity) in it as iv_arrow_img
i am iterating over the news feeds i get and for each news feed i am adding the dummy view again and again...my question is how will i distinguish between different image arrow's ids .. because for now all are having the same id... how will i set onclick listeners to them ???
.....
@devA
taking ur suggestions i have wrote the code
         Iterator itr = data.iterator();
            int i =0;
            while (itr.hasNext()) {
            NewsPostDTO newspostdto = itr.next();
        view = inflater.inflate(R.layout.rl_news_item, null);
        lnContentView.addView(view, LinearLayout.LayoutParams.FILL_PARENT, LinearLayout.LayoutParams.FILL_PARENT);

        ivArrowfwd = (ImageView) view.findViewById(R.id.iv_arrowfwd);

        tvNewsHeading.setText(newspostdto.getFeaturedDesc());
        tvNewsContent.setText(newspostdto.getDate() + " - " + newspostdto.getTitle());
        ivArrowfwd.setId(id);
        ivArrowfwd.setTag(newspostdto);
        ivArrowfwd.setOnTouchListener(new OnTouchListener(){

            @Override
            public boolean onTouch(View arg0, MotionEvent arg1) {

                               System.out.println("sdfsdf" +(ImageView) view.findViewById(id).getTag());

                return false;
            }
        });
        id++;
    }

but i am not gettng different tags for each news thought they are unique .. can u tell me where i am doing wrong... ?

A:

There are different ways to achieve this, Since its not clear what layouts you are using and how you are attaching the view to the layouts,
One way would be this, When you are populating view dynamically, use a method called    setTag("uniqueid") on the view,
unique id may be url or something else which is unique to the view and you store them in array, Once views are populated, iterate the array , use findViewWithTag("uniqueid")    and set the listener.


After much success on Xbox One with the likes of Clockwork Tales: Of Glass and Ink and Nightmares from the Deep: The Cursed Heart, Polish developer Artifex Mundi are back and this time you’ll be getting to experience The Ghosts of Maple Creek.

Arriving on April 8th, Enigmatis: The Ghosts of Maple Creek will arrive on Xbox One, giving console gamers the chance to play the first part of Artifex Mundi’s highly acclaimed series.

A detective-adventure, Enigmatis: The Ghosts of Maple Creek takes place in a small town in the middle of nowhere – Maple Creek, Vermont, USA. The main character wakes up in the evening in the middle of a road and the only thing that she can be sure of is the fact that a powerful storm has passed over the town. She can’t remember what has happened in the past few days. The chilling shivers running down her spine hint at the dramatic events that have taken place. This is the beginning of a bloodcurdling story.

As with their previous Xbox One additions, the HUD in Enigmatis has been revamped to fit the unique console controls, making it more comfortable to play on bigger screens. It’s also the longest Artifex Mundi Xbox One game yet, with up to 8 hours of gameplay and an extra adventure that is unlocked after the main story has been completed.

Features include:

A rich setting in pastoral Vermont

A spine-tingling detective story

Unique puzzles and minigames that will test your mettle

Beautiful hand-painted locations

Unlock a bonus adventure – a prequel story that lets you follow in Hamilton’s footsteps

You’ll be able to pick up Enigmatis: The Ghosts of Maple Creek for 9.99 EUR and 9.99 USD. We will of course remind you when it arrives, but for now, check out the screens below.


Feeling of incomplete emptying with little post-void residual in patients with lower urinary tract symptoms: Clinical implications and treatment outcomes.
The aim of the present study was to examine the clinical features and implications of a feeling of incomplete emptying despite little post-void residual (PVR), because it remains unclear why patients are bothered by such an undefined feeling. Data were collected prospectively from 173 consecutive patients (135 men, 38 women) with a complaint of a feeling of incomplete emptying with PVR <50 mL at an initial visit. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, overactive bladder symptom score (OABSS), prostate volume, and PVR were determined. Subjective symptoms were re-evaluated after 8 weeks of medication for co-occurring urinary symptoms. Most patients presented with high scores for a feeling of incomplete emptying, determined by Item 1 on the IPSS. The score for a feeling of incomplete emptying was positively correlated with all IPSS-related scores. Men with a feeling of incomplete emptying more often had co-occurring voiding symptoms with higher scores than women. Significant symptom relief was achieved for a feeling of incomplete emptying as well as voiding and storage symptoms after treatment. In men, there was a positive correlation between the extent of symptom relief of a feeling of incomplete emptying and voiding symptoms. A feeling of incomplete emptying with little PVR is frequently observed in routine clinical practice in both men and women, along with voiding and storage symptoms. This feeling was simultaneously improved by medications for co-occurring urinary symptoms.


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Q:

Rails: How to check if user exsists in controller and if not redirect to other site

I want to check if a user exists in the show action of my UserController. If the user does not exists, the current user should be redirected to his on profile page (via show action). The problem is it gets redirected again and again and again until the browser stops it.
If I do not use respond_to |format| (so without the redirect) and only use set_user as an equivalent to User.find(params[:id]) the path shown in the browser is the wrong path but it shows the current user.
 UserController:

  def show
    respond_to do |format|
      if User.exists?(:id)
        @user = User.find(params[:id])
        format.html
      else
        set_user
        format.html {redirect_to @user, notice: 'User does not exist' }
      end
    end
  end

  private

  def set_user
    @user = current_user
  end

So I expect the correct path in the browser and the current user to be shown if a user does not exists.
Either there is the wrong path showing the correct user or there is an infitine loop of redirections.

A:

might be a mistake the logic is correct ,
def show
respond_to do |format|
  if User.exists?(params[:id])
    @user = User.find(params[:id])
    format.html
  else
    set_user
    format.html {redirect_to @user, notice: 'User does not exist' }
  end
end
end


Q:

Does all traffic pass through a proxy server?

I'm a fuddling level computer user (do everything myself for friends and family)
I'm thinking about setting up an old Mac Mini to act as a distant proxy/vpn server.
What I'm not clear about is; does all traffic pass through a proxy server? In other words, if I connect to my proxy server then browse the internet via a wifi hotspot somewhere, is all the traffic passing through the proxy server, prior to being passed on to me? So would the speed of the connection be dependant on the upload speed of the proxy server?
Thanks for any help anyone can give.
Grant

A:

A proxy server is essentially the middle man. You request data, that goes through the proxy server to your isp. Your isp sends that data back to your proxy server then your proxy server sends it to you.
So yes, all data will go through the proxy.


Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation.
NIH 3T3 cells transformed by different activated ras genes showed different patterns of protease gene expression, indicating the existence of least two pathways for NIH 3T3 transformation from mutated ras genes. In cells transformed by activated mammalian EJ-ras and chimeric EJ/vHa-ras, high constitutive levels of urokinase plasminogen activator (uPA) mRNA and/or phorbol-12-myristate-13-acetate (PMA) inducibility of the uPA mRNA was observed. However, PMA did not induce cathepsin L (CL) mRNA levels in these same cell lines. In contrast, NIH 3T3 cells transformed by homologous yeast RAS1Leu sequences showed low levels of uPA mRNA and a lack of PMA inducibility of uPA mRNA, but did show high constitutive levels of the mRNA for CL and/or PMA inducibility of CL mRNA expression. Based on their differences in PMA inducibility these two phenotypes are designated rasuPA+/CL- and rasCL+/uPA-, respectively. Run-on assays indicated the differences in the levels of CL and uPA mRNA with ras transformation and phorbol ester induction are due to changes in transcription rates. Based on the observation of the two ras-transformed phenotypes for protease expressions, we asked whether uPA and CL can substitute for each other in the promotion of experimental metastasis. Injection of in vitro antisense inhibited cells in nude mice showed an inhibition of lung colonization by anti-uPA only in the rasuPA+/CL- phenotype and by anti-CL only in the rasCL+/uPA- phenotype. The data thus show the existence of two distinct activated ras-transformed metastatic phenotypes induced in the same parental cell line and that uPA or CL protease expressions alternatively facilitate the metastasis of cells with one ras phenotype and not with the other.


Tragedy changes people. It takes a piece of a person, never completely making them whole again. The saying “time heals all wounds” is true, however wounds leave scars, a life long reminder of the pain that you once felt. Kenneth Lonergan, a writer who’s films have a specific and special way of portraying death and the after effects it leaves on a person, manufactures his newest film “Manchester by the Sea” in a lingering fog of a tragedy.

Lee (Casey Affleck) is a janitor living near Boston. He does odd jobs like fixing faucets, shoveling snowy sidewalks, and plunging clogged toilets; but something is different about Lee, you can feel the frustration and anger in his every motion and see pain and despair behind his eyes. Lee receives an unexpected phone call from his hometown, his older brother Joe (Kyle Chandler) has died from congestive heart failure. Lee quickly returns to his hometown to handle arrangements but also to take care of his nephew Patrick (Lucas Hedges).

“Manchester by the Sea” is about people and the pains of death. Mr. Lonergan handles this aspect deftly and delicately, painting a portrait of ordinary people living in a small town dealing with death in a personal and many times genuine way. Life still moves forward without pause for compassion, little things like dinner still needing to be cooked, preparing for snow that is still going to fall, and partaking in the painstaking process of grieving. It’s uncomfortable to watch yet fascinating to see the process so meticulously staged by such a skillful writer. There is more going on still, the aspect of Joe’s death is just one component. Lee has a history in this small New England town, people recognize him and whisper condemningly in his direction.

The focus of Lee’s agony is revealed through flashbacks about half way through the film and the result is heart breaking. How do you deal with such immense tragedy? That’s the question that continues throughout the remainder of the film and is displayed through a man still dealing with the affects of death from the past and forced to handle it again in the present. You are offered two separate versions of man; it’s almost like watching two different characters completely. Lee, as a married family man, is the definition of “the life of the party”. He drinks with his friends, roughhouses with his brother, affectionately teaches his nephew how to fish, and flirts sweetly with his wife (Michelle Williams). Lee, as a lonely janitor, is cautious and measured. A man clearly dealing with emotions flowing very close to the surface, it takes everything in his power to keep those emotions restrained; sometimes they come through as aggression and anger while other times they come through as nothing more than a long stare into the distance. Mr. Lonergan builds moments that place Lee in the middle of ordinary social situations that are difficult for him function in, then into the middle of complicated situations only to watch the character drown in his own sea of self-destruction and self-loathing. You can never tell exactly how Lee will react to these circumstances, it’s an intriguing quality methodically designed by the writer/director.

Accommodating the script is a slew of fantastic performances. Casey Affleck is superb, skillfully handling the weight of the emotions in the film and delivering one of the finest, gut-wrenching performances of the year. Add to this the committed performance from Lucas Hedges who plays Patrick, a teenager trying to find a handle on the death of his father. Mr. Hedges develops the character through the different stages of the grieving process, in one moment with the kind of teenage angst you’d expect from someone his age but also with the carefree outlook that you’d expect from a young person who has lived in the same safe community his entire life.

“Manchester by the Sea” is not a film for every film fan, it's uncomfortable and grueling to watch a character suffer with these kinds of feelings for two plus hours. While the film portrays a tragedy many of us will ever know, pain and sorrow is something we can all relate with in one way or another. We all have wounds that haven't fully healed, some are still aching while others are long past the point of pain. While "Manchester by the Sea" may be polarizing for many viewers, the film displays that we all deal with pain in different ways and some us have unimaginable wounds they may be trying desperately to hide underneath a wealth of different emotions.

The Phoenix Film Festival is a program under the 501(c)3 non-profit organization Phoenix Film Foundation, and is a sibling of the Phoenix Film Society, the International Horror and Sci-Fi Film Festival, IFP/Phoenix, the Arizona Student Film Festival and the Phoenix Critics Circle. Our mission is to support and develop the artistic appreciation, educational opportunities and growth of independent film within Arizona. The Foundation's primary functions through its programs are to promote the exhibition of independent films and conduct educational programs that teach the art of filmmaking


Biochemical reactions within cells define cellular function and activity. These reactions include a complex interplay between receptor ligand interactions and enzymatic reactions, which orchestrate the signaling and activities of a cell. Physiological conditions influence the activity levels of enzymes and proteins mediating these reactions.
For example, modifications of amino acid residues on peptide chains play an important role in the regulation of protein function in cells. Transfer of phosphate groups, methyl groups or carbohydrates induces conformational changes in protein substrates, which in turn results in changes in protein function. These reactions are usually reversible. Protein modification involves particular classes of enzymatic activities. For example, methylation is generally catalyzed by a family of enzymes, known as methyltransferases. Protein methylation regulates membrane attachment of cytosolic proteins and contributes to prevention of C-terminal proteolytic degradation of peptides. For example, most G proteins are methylated. The methylated cysteine residue is located at or near the carboxyl terminus of G proteins may facilitate attachment of the peptides to the membrane for signal transduction (Rando, Biochim BiophysActa 1300(1):5–12 (1996), Hrycyna, Pharmacol. Ther. 59(3):281–300 (1993)). Histidine at position 73 on several kinds of actin is also methylated. It has been shown that methylation is required for maintaining proper conformation of actin molecules (Yao, J. Biol. Chem. 274(52):37443–9 (1999)). Methylation of lysine residue in the S-1 region of myosin results in decreased ATP binding in myofibrine contraction (Bivin, Proc. Nat'l Acad. Sci USA 91(18):8665–9 (1994)). It has also been shown that methylation of membrane proteins may contribute to the development of cardiovascular disease in diabetic patients (Schaffer, Mol. Cell Biochem 107(1):1–20 (1991)). In addition, methylation reduces protein-RNA interaction in nuclear proteins (Kim, Amino Acids 15(4):291–306 (1998)), and selectively modulates SH3 domain-mediated protein-protein interactions (Bedford, J. Biol. Chem, 275(21):16030–6 (2000)).
Similarly, carbohydrates can be transferred to side chains of specific asparagine, serine, or threonine residues in many secreted proteins or proteins displayed on cell-surfaces. The transfer of a carbohydrate to asparagine at position 2181 on human coagulation factor V results in impaired interaction between factor V and phospholipid membranes (Nicolaes, Biochemistry 38(41):13584–91 (1999)). Large carbohydrates, known as polysaccharides, are formed by linking many sugar monomers.


301 S.W.2d 161 (1957)
Wilburn Monroe HALL, Appellant,
v.
The STATE of Texas, Appellee.
No. 28688.
Court of Criminal Appeals of Texas.
January 23, 1957.
Rehearing Denied March 27, 1957.
*162 Russell F. Wolters, Houston, for appellant.
Dan Walton, Dist. Atty., Eugene Brady and Thomas D. White, Asst. Dist. Attys., Houston, and Leon B. Douglas, State's Atty., Austin, for the State.
BELCHER, Commissioner.
The conviction is for murder; the punishment, death.
The evidence shows that the deceased, Samuel Ross MacGregor and his wife, Joy Lee MacGregor, were separated on December 17, 1954. Shortly after their separation the deceased spent seven months in a mental institution in Austin, then after his release on September 26, 1955, returned to Houston where he lived in the home of his mother and step-father, Mr. and Mrs. W. C. Clayton. Mrs. Clayton operated a cafe which was located next door to her residence. Joy Lee, who lived in Houston, went to the cafe *163 about 4:45 P.M., April 1, 1956, visited with Mrs. Clayton, and when her husband (the deceased) arrived, went outside, talked with him a short time and left. About 11 P.M., after the deceased had retired and was asleep, the discharge of a gun was heard and an investigation by the Claytons and the officers showed that the deceased had been shot from the outside of the residence through a window while he lay in bed asleep with his back to the window, and the top of his head had been blown off as the result of his having been shot by a .12 gauge shotgun.
The proof shows that the appellant had become fond of Joy Lee, the deceased's wife, and had been keeping company with her for about four months, and that she had told him that she had been abused and mistreated by the deceased.
Deputy Sheriffs Irby and Hutchinson, being unable to locate the appellant and Joy Lee immediately after the deceased was shot, watched for them near her apartment until a car appeared about 6 A.M. They approached the car and found the occupants to be the appellant and Joy Lee. Among appellant's first words spoken to the officers were "that Joy didn't know anything about it, I am the one you want", and he later asked them "if Sam was dead." A search of the appellant revealed four .12 gauge shotgun shells in his left pocket. They asked appellant where the shotgun was that he used and he replied that it was in the car under the front seat which they found as he had told them. The gun was loaded. Appellant told the officers that he had thrown the empty shell away. They also found nineteen .12 gauge shells in the glove compartment of the car.
The state introduced appellant's voluntary written statement made to Deputy Sheriff John S. Fox concerning the shooting of Samuel Ross MacGregor and it was admitted in evidence without objection. It reads in part as follows: "My name is Wilburn Monroe Hall, I am 28 years old * * *. Sometime in December, 1955, I met Joy Lee MacGregor * * *. I knew that she was married to Sam MacGregor and (had) three children by him but had been seperated from him for some time. * * * Yesterday, April 1, 1956, Joy her children and I went to Huf Smith in a 1953 Ford which I had stolen off of a lot on Washington Ave. on March 27, 1955. We stopped at a cafe in Huf Smith and the children and I got out of the car, Joy Lee went on down to Sam's Mother's place. She went there to see Sam as he had told her on the phone about a week and a half ago to come and see him about straightening their property. * * * I got the gun and shells with the intention of going to Huf Smith and killing Sam. I drove to Huf Smith and parked the car just up the street from Sam's Mother's place. I put a few of the shells in my pocket and and taking the gun I walked down the road and along the south side of Sam's Mother's place and climbed over a barb-wire fence and walked around back of the beer joint and then back of the house. The house was dark so I came out the side gate between the house and the beer joint into a drive way and looked in the window of the beer joint to see if Sam was there. * * * Then I went to the window of the back room of the house and saw Sam lying on his side on the bed with his back to me. While I was looking at Sam I saw the old man come from the back and go thru Sam's room to the front part of the house. I stood at the window a little bit after the old man had gone from the room and then I raised the gun and aimed it at the back of Sam's head and fired. I had the end of the barrel of the gun about a foot or two from the window when I fired. As soon as I fired I went back the way I had come in to the place and got in the car which I had headed for Houston and come on back to town. After I shot Sam I reloaded the gun and put the empty shell in my pocket, I threw it away later. I don't know where. I went to the Grove on Jensen Drive and saw Joy Lee who was still with Jack. She told me to meet her in about an hour at her house. I don't know what time I shot Sam but it was 12:15 AM when I got to the Grove. I *164 picked Joy Lee up about 1:30 AM and we rode around and parked for a while. We came back and stopped about two houses away from Joy Lee's and the officers came to the car and placed us under arrest this was about 6:00 AM this morning, April 2nd, 1956. I still had the shotgun and the balance of the shells in the car at that time. * * *"
In rebuttal the state called Dr. C. W. Dwyer who testified that he had been the psychiatrist for Harris County for ten years; that he had examined the appellant and in his opinion he was of sound mind and knew the difference between right and wrong.
Appellant, testifying in his own behalf, stated that the witnesses for the state had testified truthfully, that he had not been mistreated, and admitted that he made the written statement to Deputy Sheriff Fox which had been introduced in evidence, but stated that he was not under oath when he made said statement. He further testified that he was not guilty but knew how the killing occurred because he heard two strangers making plans to kill the deceased; and that he confessed to the crime and signed the statement because he had a past record and knew that the officers would investigate Joy Lee in connection with deceased's death and try "to make a big fool out of her." He admitted his affection for Joy Lee and that he would like to have her as his wife; and that he had heard that a wife could not divorce a husband while he was a mental patient.
J. W. Cooper, called by the appellant, testified that he didn't know whether the appellant knew right from wrong when he last saw him on March 24, 1956, but that he was then of unsound mind or under the influence of dope.
Appellant's brother, Woodrow Hall, testified that the appellant knew right from wrong but that he had the mind of a sixteen year old boy.
Joy Lee MacGregor, widow of the deceased, called by the appellant, admitted that she had been keeping company with and making love to the appellant; that she had told him that the deceased had shot at her three times and that they had had a fight; that the appellant told her about 1:00 A.M. that he "shot Sam", and that she later saw him that night and remained with him until 6 A.M.
The evidence is sufficient to support the jury's verdict.
There were no requested charges or exceptions to the charge submitted to the jury.
No formal bills of exception appear in the record. Six informal bills are presented.
Appellant complains of the use by a state's witness on direct examination of the words "Easter Sunday" which the court refused to delete.
In his oral argument and brief appellant urges that because of certain religious convictions concerning Easter Sunday which is the date of the offense here charged, the appellant could have been injured if any juror possessed such convictions.
The record discloses the use of the words complained of numerous times during the examination of witnesses without objection. The record fails to support appellant's claim that the reference to Easter Sunday as the day on which the offense was committed was prejudicial to his defense. In the absence of such a showing we would not be authorized to reverse this conviction.
Appellant complains of the admission in evidence of testimony that "there was brains about four inches in diameter right over the left side of the dresser" and on the wall on the ground that it was not material.
Ordinarily, the physical facts and circumstances surrounding a homicide are admissible *165 in evidence as tending to throw light on the transaction and to reveal its nature. In Hanie v. State, 151 Tex.Cr.R. 395, 208 S.W.2d 373, 375, where the appellant complained of the admission of testimony as to the condition of the houseboat where the homicide took place, we said:
"* * * It is contended that this evidence about `blood and brains' is inflammatory and prejudicial. Probably so. Most evidence describing a murder is inflammatory and prejudicial, but as a general rule is admissible to show the circumstances of the killing, and frequently serves a useful purpose in enabling the jury to fix appropriate penalty. We find nothing in this testimony preventing its admission under the rules."
After the state's witness Knowles had testified that he was familiar with shotguns and shotgun shells he was asked to examine the shotgun shells introduced in evidence and then asked: "Is that such a shell you would use to go bird hunting or squirrel hunting?", and the witness answered: "Not hardly." To which appellant stated: "Object to the testimony about bird hunting or squirrel hunting", which was overruled. The matter was not thereafter referred to. Immediately prior to the objection the witness had testified that the shells in evidence contained magnum No. 4 shot, and were a quarter of an inch longer than the standard shell, and "has more power than the normal shell, which gives it a higher velocity and more penetrating and hitting power."
We perceive no injury to the appellant by reason of such testimony and especially in view of his confession introduced in evidence that he got the gun and shells with the intention of killing the deceased.
Appellant objected to the testimony of John S. Fox concerning a window screen because the witness had testified he examined the one on the south side whereas other testimony shows that the screen came from the west side.
The screen had been previously introduced in evidence and the witness had identified it. He testified that when he went on the outside of the house to this back window he could see the body of the deceased on the bed and by stooping a little the hole in the screen was in line with the deceased's head. When the testimony is considered as a whole in regard to the windows and the screen, no error is revealed.
Appellant insists that the court erred in requiring his brother, Woodrow Hall, to testify over his objection that he owned the shotgun that had been introduced in evidence.
Appellant, while testifying, stated that he got the gun out of his brother's house, and his written statement introduced in evidence recites that he "got my brother's single barrel.12 gauge shotgun and a full box of shells." We perceive no error.
Finding no reversible error, the judgment is affirmed.
Opinion approved by the Court.
On Appellant's Motion for Rehearing
DICE, Judge.
Appellant insists that because of the testimony in the record that he had the "mind of a sixteen year-old boy" the evidence is insufficient to sustain the verdict fixing his punishment at death and the verdict is contrary to both the law and the evidence.
While Art. 31, Vernon's Ann.P.C., provides that "a person for an offense committed before he arrived at the age of seventeen years shall in no case be punished with death", such statute is not applicable in the present case as the evidence shows that appellant was twenty-eight years of age at the time of the trial and over the age of *166 seventeen years on the date the offense was committed. Under the provisions of the statute it is the age of the accused that controls as to whether he may be punished with death rather than the degree of his mentality.
We have again examined the record in the light of the other contentions presented by appellant in his motion for rehearing and remain convinced that we properly disposed of the cause on original submission.
The motion is overruled.
Opinion approved by the Court.


using MvcSiteMapProvider.Collections.Specialized;
using System;
using System.Collections.Generic;
using System.ComponentModel;
using System.Web.Mvc;

namespace MvcSiteMapProvider
{
    /// <summary>
    /// Contract for the specialized class that manages the hierarchical relationship between different
    /// <see cref="T:MvcSiteMapProvider.ISiteMapNode"/> instances.
    /// </summary>
    public interface ISiteMap
    {
        // Data structure management
        bool IsReadOnly { get; }
        void AddNode(ISiteMapNode node);
        void AddNode(ISiteMapNode node, ISiteMapNode parentNode);
        void RemoveNode(ISiteMapNode node);
        void Clear();
        ISiteMapNode RootNode { get; }

        // Hide the BuildSiteMap method because it is only for use by MvcSiteMapProvider.
        [EditorBrowsable(EditorBrowsableState.Never)]
        void BuildSiteMap();

        ISiteMapNode CurrentNode { get; }
        bool EnableLocalization { get; }
        ISiteMapNode FindSiteMapNode(string rawUrl);
        ISiteMapNode FindSiteMapNodeFromCurrentContext();
        ISiteMapNode FindSiteMapNode(ControllerContext context);
        ISiteMapNode FindSiteMapNodeFromKey(string key);
        ISiteMapNodeCollection GetChildNodes(ISiteMapNode node);
        ISiteMapNodeCollection GetDescendants(ISiteMapNode node);
        ISiteMapNodeCollection GetAncestors(ISiteMapNode node);
        ISiteMapNode GetCurrentNodeAndHintAncestorNodes(int upLevel);
        ISiteMapNode GetCurrentNodeAndHintNeighborhoodNodes(int upLevel, int downLevel);
        ISiteMapNode GetParentNode(ISiteMapNode node);
        ISiteMapNode GetParentNodeRelativeToCurrentNodeAndHintDownFromParent(int walkupLevels, int relativeDepthFromWalkup);
        ISiteMapNode GetParentNodeRelativeToNodeAndHintDownFromParent(ISiteMapNode node, int walkupLevels, int relativeDepthFromWalkup);
        void HintAncestorNodes(ISiteMapNode node, int upLevel);
        void HintNeighborhoodNodes(ISiteMapNode node, int upLevel, int downLevel);
        bool IsAccessibleToUser(ISiteMapNode node);
        string CacheKey { get; }
        string ResourceKey { get; set; } // TODO: Remove setter in version 5.
        bool SecurityTrimmingEnabled { get; }
        bool UseTitleIfDescriptionNotProvided { get; }
        bool VisibilityAffectsDescendants { get; }
        Type ResolveControllerType(string areaName, string controllerName);

        [Obsolete("ResolveActionMethodParameters is deprecated and will be removed in version 5.")]
        IEnumerable<string> ResolveActionMethodParameters(string areaName, string controllerName, string actionMethodName);
    }

    public static class SiteMapExtensions
    {
        public static string GetUrlContextKey(this ISiteMap siteMap)
        {
            return "__MVCSITEMAP_" + siteMap.CacheKey + "_UrlContext_" + siteMap.IsReadOnly.ToString() + "_";
        }
    }
}


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This is What Courageous Parenting Looks Like

Before I had children, nobody told me that the sleepless nights would not stop when my babies grew into big kids and teenagers. I didn’t know that worry would be my constant companion as I watched their chubby bodies slim and lengthen until they were full-size humans. I was unaware that parenting would require more courage than anything I had ever done.

In the nearly 18 years that I have been muddling through the maze of raising children, I have witnessed the moral fabric of society disintegrating at an increasingly alarming speed. One must only turn on the television, scroll through Facebook and Twitter feeds, or open a newspaper to see that time-honored values surrounding family, faith, and even religious freedom are under attack.

Confusion is rampant, controversy is thick, and it is difficult to sort through the vast sea of information to determine what is true and what is not. Truth, it seems, has become a question of relativity, where nothing is ever absolute.

Those of us who believe in absolutes (God’s commandments, for instance) are facing an uphill battle. It gets even more complicated (and scary) when we throw children into the mix because we are attempting to teach them values that are becoming increasingly unpopular.

What will that mean for their futures?

Will they be ridiculed for the things that we teach them?

Will they be wooed by progressive thinkers who trivialize or demonize their Christian upbringing?

Will they be able to remain strong in their moral convictions, despite the opposition that they will inevitably encounter?

How much further will society’s morality fall in the years to come?

In the face of such daunting questions, it can feel overwhelming to teach children that the Lord’s laws are not negated by a society that does not uphold them. It is especially challenging when we consider that giving our kids the tools to stand firm in defense of traditional values is setting them up for opposition, for mockery, for persecution.

But that does not mean we should shy away from teaching them such things. The future of the world is in the hands of the rising generation.

Unless we want faith to go the way of the dodo bird, we, as parents and believers, must teach our kids to live in the light of its influence. If we fail to do so because we are afraid of the consequences (or for any other reason), the world with all of its moral relativism and deceit will be happy to fill the void. I don’t know about you, but I would not be satisfied with the results of that teaching.

Like I said, this parenting business takes courage. It takes every ounce of bravery that is inside of us to look at the disheartening moral decline and the consequences that believers are facing for going against the grain and teach our children to live by faith anyway.

It requires keeping open lines of communication with our kids about everything, especially the tough subjects.

It requires teaching truth clearly and consistently, even when there is potential for offense. If we avoid teaching doctrine that may offend, we would be sidestepping the very topics that have the greatest potential for confusing and challenging our kids.

Courageous parenting requires saying no when others are saying yes, and yes when others are saying no, even when the kids don’t like it.

It requires making tough calls and being a parent to our children before, and sometimes at the expense of, being their friend.

It requires making faith and family our top priorities.

I know it is intimidating to look at the environment in which our children are growing up and stay hopeful that they will emerge unscathed, with their faith still intact. Sometimes I feel grossly underqualified for this work, and courage seems far out of reach.

That is why I am grateful to know that I do not have to do this alone. I can call upon the one who knows all – who can see the end from the beginning and is genuinely interested in what is happening in my family.

He, alongside my husband, is my partner in raising children. It is comforting to know that He is never more than a prayer away, ready to provide guidance and help along this treacherous path of child rearing.

Parenting is not for the faint of heart. But you, my friends, are not faint of heart. I am confident that there is more courage inside of you than you realize. I invite you to dig deep, find it, and bring it to the surface, so it is readily accessible. Together, let us choose to be brave.

How do you find courage amidst opposition? What does courageous parenting mean to you? Tell me about in the comments section below.

If you enjoyed this post, you might also like my free email course entitled, Courage to Stand, where I walk you through why it is important to stand for morality and how to develop the courage to do so. Sign up today!

Courageous parenting is not easy, but it often produces courageous kids who carry that legacy on to the next generation. And that is what is needed. It also reminds me of a conversation I had yesterday with a good friend. She said, “You never told me that parenting 18 year old kids would take so much of my time and energy. i thought they would just leave for college and I would be done.” I just laughed, and so did she. Because when you have a good relationship with your kids they sometimes need you even more when you are thinking the end is in sight.


It's been common knowledge in the wider PKI community that Symantec, the Certificate Authority, is currently being distrusted and will soon cease to exist as a CA. My worry is that the wider community doesn't seem fully prepared for the distrust and the impact it will have.

Symantec

There's a whole, big (really big) back story to Symantec being distrusted by the browsers but it can be distilled down to the fact that they did some things that made the browsers lose faith in them, they issued certificates that they shouldn't have issued. You can read Chrome’s Plan to Distrust Symantec Certificates and the long thread on Mozilla's Dev Security Policy mailing list about exactly why, but one way or another Symantec will cease to exist as a CA. Despite sanctions like Google requiring Certificate Transparency compliance from Symantec ahead of the requirement for all other CAs, it seems there was no coming back and Symantec sold off it's entire CA business to DigiCert and will exit the market. This is a problem for site operators because they now need to find a new CA, which will hopefully be a lot easier now they can transition to DigiCert, but the bigger issue is that if you're using an existing Symantec certificate you need to replace it, and this is where things get interesting.

The deadlines

There are 2 deadlines by which sites need to take action and they depend on when you got your Symantec certificate. If the certificate was issued prior to 1st June 2016 it will stop working with the Chrome 66 release in April 2018 and if you have any other Symantec certificate it will stop working with the Chrome 70 release in October 2018. Prompted by other research I'd seen online I thought I'd put my crawler data to good use and see what further analysis I could do with it.

Who is still using Symantec certs

After creating a script to go through the certificates collected by my crawlers I can parse them all and see who is still using a Symantec cert that will be distrusted. I've broken the list down into 2 separate files; the sites using certificates that will be distrusted in m70 and the sites who will have their certificate distrusted in m66 who need to take more immediate action. You can see the code over on my GitHub repo and the two files that contain the lists of sites are m66.csv and m70.csv respectively.

The M66 distrust

I'm currently seeing 1,321 sites in the Alexa Top 1 Million that will have their current certificate distrusted in April. That's a pretty large number and with less than 2 months to go, I hope they're already underway with replacing the certs.

The M70 distrust

For M70 the numbers are slightly higher, as you'd expect, and I'm seeing 6,882 sites that will have their certificates stop working in September. That's a much more acceptable timeframe and I will track the numbers as we go.

A basic db query

The above numbers were acquired by parsing the certificates that were collected and looking for ones that chain to a blacklisted Symantec root. Another much more simple approach is to look for instances of 'Symantec' in the name of the CA.

SELECT ca, count(ca) FROM `results` WHERE ca LIKE '%Symantec%' GROUP BY ca ORDER BY count(ca) DESC

That gives me the following list.

C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 Secure Server CA - G4 3884 C = US, O = Symantec Corporation, OU = Symantec Trust Network, OU = Domain Validated SSL, CN = Symantec Basic DV SSL CA - G2 2764 C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 EV SSL CA - G3 2703 C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 ECC 256 bit SSL CA - G2 499 C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 Secure Server SHA256 SSL CA 401 C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 Extended Validation SHA256 SSL CA 310 C = US, O = Symantec Corporation, OU = Symantec Trust Network, OU = Domain Validated SSL, CN = Symantec Basic DV SSL CA - G1 192 C = CN, O = "TrustAsia Technologies, Inc.", OU = Symantec Trust Network, OU = Domain Validated SSL, CN = TrustAsia DV SSL CA - G5 186 C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 ECC 256 bit EV CA - G2 123 C = US, O = Wells Fargo, OU = Symantec Trust Network, CN = Wells Fargo Certificate Authority WS1 11 C = US, O = Oracle Corporation, OU = Symantec Trust Network, CN = Oracle SSL CA - G2 2 C = US, O = Symantec Corporation, OU = Symantec Trust Network, CN = Symantec Class 3 EV SSL CA - G2 1

One way or another, that's still an awful lot of Symantec issued certs...

Check the lists

It'd be worth taking a look through the lists and seeing if your site is on there and if it is, make plans to remove it! As the script can be run against my daily crawl data it will be easy to keep this up to date and to monitor it as we get closer. Perhaps in the last week or two it might be worth reaching out to organisations publicly to see if they're aware of the impending change. To confirm if a site is affected you can visit it in the latest version of Chrome and check the console for an error message:

The other great thing to note from that example is that my scans only hit the apex domain on http and follow redirects to completion, meaning there will be many more sites that have a Symantec cert that will be affected but don't currently redirect to it. I also won't pick up resources on the page loaded from subdomains or other 3rd party domains that are impacted by this distrust. I guess the point is that this is only the tip of the iceberg and there are a lot more sites out there that will be affected.


Q:

How to simplify this differentiated equation further?

The question I have is sqrt(2x-1) / 2e^3x and I am asked to differentiate and simplify.
This is my working below:

I am unsure of how to get to simplify this to get the final answer in the textbook shown below:

What do I have to do?

A:

Starting from your result, since $\frac{e^{3x}}{3^{6x}} = e^{-3x}$, $(2x - 1)^{\frac{1}{2}} = (2x - 1)^{-\frac{1}{2}}(2x - 1)$ and $(2x - 1)^{-\frac{1}{2}} = \frac{1}{\sqrt{2x - 1}}$,
$$\begin{equation}\begin{aligned}
& \frac{2e^{3x}\left((2x - 1)^{-\frac{1}{2}} - 3(2x - 1)^{\frac{1}{2}}\right)}{4e^{6x}} \\
& = \frac{e^{-3x}\left((2x - 1)^{-\frac{1}{2}} - 3(2x - 1)^{-\frac{1}{2}}(2x - 1)\right)}{2} \\
& = \frac{e^{-3x}(2x - 1)^{-\frac{1}{2}}\left(1 - 3(2x - 1)\right)}{2} \\
& = \frac{e^{-3x}\left(1 - 6x + 3)\right)}{2\sqrt{2x - 1}} \\
& = \frac{e^{-3x}\left(2\left(2 - 3x\right)\right)}{2\sqrt{2x - 1}} \\
& = \frac{\left(2 -3x\right)e^{-3x}}{\sqrt{2x - 1}}
\end{aligned}\end{equation}\tag{1}\label{eq1A}$$
This matches the final result shown for $g'(x)$ in $242$ in your image.


WASHINGTON — President Trump on Sunday issued a new order indefinitely banning almost all travel to the United States from seven countries, including most of the nations covered by his original travel ban, citing threats to national security posed by letting their citizens into the country.

The new order is more far-reaching than the president’s original travel ban, imposing permanent restrictions on travel, rather than the 90-day suspension that Mr. Trump authorized soon after taking office. But officials said his new action was the result of a deliberative, rigorous examination of security risks that was designed to avoid the chaotic rollout of his first ban. And the addition of non-Muslim countries could address the legal attacks on earlier travel restrictions as discrimination based on religion.

Starting next month, most citizens of Iran, Libya, Syria, Yemen, Somalia, Chad and North Korea will be banned from entering the United States, Mr. Trump said in a proclamation released Sunday night. Citizens of Iraq and some groups of people in Venezuela who seek to visit the United States will face restrictions or heightened scrutiny.

Mr. Trump’s original travel ban caused turmoil at airports in January and set off a furious legal challenge to the president’s authority. It was followed in March by a revised ban, which expired on Sunday even as the Supreme Court is set to hear arguments about its constitutionality on Oct. 10. The new order — Chad, North Korea and Venezuela are new to the list of affected countries and Sudan has been dropped — will take effect Oct. 18.


Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor.
Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many tissues. However, the role of Spd in hyperglyceamia-induced neuronal senescence remains unexplored. Therefore, we used high glucose (HG)-treated HT-22 cell as vitro model to investigate whether Spd protects neurons against hyperglyceamia-induced senescence and the mediatory role of CB1 receptor. The HT-22 cells were cultured in HG condition in the presence of different dose of Spd. Then, the viability of cells was measured by Cell Counting Kit-8 (CCK-8) assay. The senescence of cells was detected by Senescence-associated β-galactosidase (SA-β-Gal) staining. The expressions of p16INK4a , p21CIP1 and CB1 receptor were measured by western blot. We found that Spd inhibited HG-induced neurotoxicity (the loss of cell viability) and senescence (the increase of SA-β-Gal positive cells, the upregulation of p16INK4a and p21CIP1 ) in HT-22 cells. Also, Spd prevented HG-induced downregulation of CB1 receptor in HT-22 cells. Furthermore, we demonstrated that AM251 (a specific inhibitor of the CB1 receptor) reversed the protective effects of Spd on HG-induced neurotoxicity and senescence. These results indicated that Spd prevents HG-induced neurotoxicity and senescence via the upregulation of CB1 receptor. Our findings provide a promising future of Spd-based preventions and therapies for diabetic encephalopathy.


Soda Can P-40 Warhawk 1:32nd scale using FG pattern

While I am continuing to update the FG build tutorial on the Grumman Hellcat, I thought I would share the results of another recent build using the FG P-40 Warhawk pattern to build one of my favorite movie aircraft models, Joseph Sullivan's modified P-40 from the film Sky Captain and the World of Tomorrow. Using the large pattern, modified as shown in the FG Hellcat tutorial, I built this model using many of the same techniques demonstrated in that thread. Here is how it turned out:

As you can see, I used a combination of white and red can to cut out the teeth, eyes and the signature markings on the side of the aircraft as seen in the film. As usual, I opted for a clear canopy and windows because the added realism simply sets these apart from models in which reverse can is used for the canopy.

The model came in right at 12 inches long with a 15 inch wingspan and we can now send Sky Captain off to fight with The Flying Legion once again, with a little Pepsi of course!

The lettering and the teeth were a bear, but it really makes the model. I've seen the P-40 built out of cans before on another forum, but the builder neglected to take advantage of his ability to make markings and insignias and the model fell flat in my humble opinion. To me, if you're going to put that much effort into a nice build such as this, you might as well finish it off, right?!

Loved the movie and always wanted to build the plane. Now its hanging just to the right of the 3.5 foot F-15 hanging over my head...!!!


After Pakistan Refused to Take Part in War against Yemen…A Racist Caricature against Pakistanis in a Bahraini Paper

SHAFAQNA –The 76-year-old Bahraini caricaturist, Abdullah Al Muharraqi, published a racist caricature against the Pakistanis after the Parliament of Pakistan decided last week not to take part in the war against Yemen and backed neutrality in the conflict. The caricature published in Akhabr Al Khalij newspaper affiliated to the Bahraini Prime Minister, Khalifa bin Salman, shows an image for the Saudi king, Salman bin Abdulaziz, holding a bag of money in his one hand and a firearm in his other and giving them to a Pakistani lying down in a bed. In the caricature, the king is represented saying to the Pakistani “Go Fight”, while the later answers, “I can’t”. The king then says, “Take This” referring to the money, the Pakistani replies, “Oh! Really”. The dialogue reflects the nature of the Saudi-Pakistani relation, on the government and people level, which build on giving commands in return for money.

This caricature expresses a racist and arrogant look from the side of gulf states’ rulers towards Pakistan and its 180 million people, who are always regarded as poor people and whom governments of gulf provides with money.

These Pakistanis, from their part, have to agree on the orders issued by the gulf rulers even if the orders were contrary to the Pakistani interests.

It is to mention that Abdullah Al Muharraqi is born in 1939 and has worked for Akhabr Al Khalij newspaper affiliated to the Bahraini Prime Minister Khalifa bin Salman, since 1976.


Percutaneous nephrostomy--techniques.
Percutaneous nephrolithotripsy has become a widely accepted procedure, that permits the removal of up to 90% of all renal calculi with minimal morbidity and success rates of over 95%. Together with extracorporeal shock wave lithotripsy and the introduction of the ureterorenoscope it has revolutionised the surgical therapy of this clinical entity, and has reduced the need for open surgical interventions to approximately 5% of the numbers required before these methods became available. The success of percutaneous endoscopic surgery depends mainly on the correct position of the percutaneous nephrostomy, which must provide access to all renal calculi via a straight tract, yet should avoid significant trauma to the kidney or perirenal structures. This situation differs from the requirements for simple drainage of obstructed kidneys, as the collecting system of stone bearing kidneys is usually not dilated and the tract has to be adapted to the specific anatomical situation. Special techniques and material have been developed to meet these demands. The purpose of this article is to present our approach, based on percutaneous nephrolithotripsy in 2100 reno-ureteral units. Special reference is given to difficult anatomic situations, which frequently result in failure in inexperienced hands.


Q:

not able to delete the index from the array and make it available again for new inputs

 My To-do List

        <form>

         <input type="text" id="inputUser" placeholder="Type your task here - minimum four characters"
                class="textfield">

        <button type= "button"  id ="addBtn" title = "Add Task"></button>
        <button type= "button"  id ="removeBtn"></button>

        </form>

Here is my html file

 $(function () {
 var myTaskArray = [];

     $("#addBtn").click(function () {
         var newItem = $('#inputUser').val();
         myTaskArray.push(newItem);

         if (myTaskArray.length > 10) {
             alert("Your Schedule for today is now full!");
             $('#inputUser').val('');
             return;

         } else if (newItem.trim() == "" || newItem.length < 3) {
             alert("You need to write a task");

         } else {

             $("#list").append("
<input type = 'checkbox' id = 'checkbox'>" + "  " + newItem + "
");

             $("input:checkbox").click(function () {
                 var $this = $(this);
                 if (this.checked) {
                     $this.parent().addClass('completed');

                 } else {
                     $this.parent().removeClass('completed');
                 }
             });
         }
         $('#inputUser').val('');
     });

     //remove item on the list
     $("#removeBtn").click(function () {
         $('#list').children().filter(function () {
             return this.firstChild.checked;
         }).remove();
     });

 });

Here is my js file. I put a limit up to max 10 inputs from the users and It works as it is but when I remove som values through remove button, the index of that values doesn't remove from the array and make it available again for inputs. Is there anyway I can fix this?

A:

You are not limiting the list to 10 items, but to 11 items. Use the <= operator (<= 10) or < 11 to limit it to 10 items.
You are adding items to your array, even if the text is empty or the list is already full. Move myTaskArray.push() to the else statement.
You are never updating your myTaskArray array when deleting a todo list item. See my code example for how to do this using Array.prototype.filter().

(For demonstration purposes, I limited the list to 3 items and added logging of the underlying array when adding or removing a list item)

$(function() {
  var myTaskArray = [];

  $("#addBtn").click(function() {
    var newItem = $('#inputUser').val();

    if (myTaskArray.length >= 3) {
      alert("Your Schedule for today is now full!");
      $('#inputUser').val('');
      return;

    } else if (newItem.trim() == "" || newItem.length < 3) {
      alert("You need to write a task");

    } else {
      myTaskArray.push(newItem);
      console.clear();
      console.log("myTaskArray:", myTaskArray);
      $("#list").append("
<input type = 'checkbox' id = 'checkbox'>" + "  " + newItem + "
");

      $("input:checkbox").click(function() {
        var $this = $(this);
        if (this.checked) {
          $this.parent().addClass('completed');

        } else {
          $this.parent().removeClass('completed');
        }
      });
    }
    $('#inputUser').val('');
  });

  //remove item on the list
  $("#removeBtn").click(function() {
    let itemsToRemove = [];
    $('#list').children().filter(function(index) {
      let removeThis = this.firstChild.checked;
      if (removeThis) {
        itemsToRemove.push(index);
      }
      return removeThis;
    }).remove();
    myTaskArray = myTaskArray.filter(function(value, index) {
      return !itemsToRemove.includes(index)
    });
    console.clear();
    console.log("myTaskArray:", myTaskArray);
  });

});

 My To-do List

<form>

    <input type="text" id="inputUser" placeholder="Type your task here - minimum four characters" class="textfield">

    <button type="button" id="addBtn" title="Add Task">+</button>
    <button type="button" id="removeBtn">x</button>

</form>

Some followup thoughts:

Usability: Allow adding an item using the enter key in the input (currently that submits the form)
Usability: Disable the input field when the list is full, displaying an info message or at least changing the input placeholder text instead of allowing the user to type, but showing the error message upon input and erasing the user's input completely
Maybe use a reactive framework like Vue.js that uses the underlying array for rendering the list instead of having to update both data and representation manually.


OverviewWade Wilson is a mercenary with a Special Forces background. After being diagnosed with cancer, he agrees to be part of an experimental project designed to turn him into a super soldier with accelerated healing and drug, toxin and disease resistance. Yet, this rogue experiment does much more: Instead of destroying his cancer, it makes the cells a permanent part of his body. It disfigures him and destabilizes his mind making him incredibly violent and unpredictable. With a dark sense of humor, a twisted sense of morality and the need for revenge, Wade Wilson becomes the anti-hero known as Deadpool.


It’s been years since a large portion of colon cancer patients have seen any innovations in treatment. However, there are dietary and physical behavioral changes individuals can make that positively impact colon cancer survival said Leonard Saltz, MD, executive director of Clinical Value and Sustainability, head of Colorectal Oncology Section, Memorial Sloan Kettering Cancer Center.

Are there any novel approaches currently being taken in the treatment of colon cancer?

Colon cancer’s an area where we’re stalled, to be blunt. We haven’t had, in my opinion, a really important innovation for the majority of patients since 2003. So, we’ve been in a 15-year, kind of, stagnant period. The most important innovation in the last few years has been recognizing that the limited number of patients with mismatch repair deficit or high microsatellite instability tumors can benefit from PD-1 inhibitors and can benefit very substantially from them, whereas, the other patients with microsatellite stable or mismatch repair proficient disease do not benefit from those agents.

Now, the mismatch repair deficiency tumors, in general, are a favorable prognosis, which means that a lot of them don’t even become stage 4. So, when we look at the metastatic or stage 4 patients, who are mismatch repair deficient, its somewhere between 2% and 4% of the entire colorectal population. Important for those 2% to 4%, but it doesn’t help the rest.

What behaviors have you identified that impact colon cancer survival?

We published a number of articles on those topics, and a lot of this goes back to a clinical trial that I led a number of years ago, where we were looking at 2 different therapies for adjuvant treatment of stage 3 colon cancer. The trial was a negative trial. The experimental regimen was no better than the standard. But, my colleagues at Dana-Farber had attached a very detailed dietary and activity questionnaire to that study, and more than 900 patients filled it out, 3 months and 12 months after their survey. So, we were able to look back after 5 years or more, and look for correlations between who stayed cancer-free and who didn’t, and a number of very important aspects came out.

People who reported maintaining a high correlation with what the Harvard School of Public Health calls "the prudent diet," basically a pescatarian diet, vegetarian plus seafood with an emphasis on whole grain, low in animal fat, low in refined grain, low in sugar, did substantially better than people with a, what we’ve euphemistically called, a western diet, a junk food diet, essentially, high in refined carbohydrates and high in animal fat. We saw that people that got regular aerobic exercise had a substantial risk reduction compared to people that basically were bed to chair or sedentary, and we saw, within the dietary breakdown, certain correlations that were rather interesting.

Tree nuts were favorable, and it’s important to emphasize that does not include peanuts, which are not actually a nut; they’re a legume. High consumption of all the other nuts we think about, cashews, almonds, walnuts, pistachios, are correlated with favorable outcome. We think that means it’s a good idea to eat them, of course, it’s a retrospective observational study, so we don’t know.

To my great delight, we found that coffee was a good thing, and that, people who reported drinking 4 or more cups, and at the time we did a cup as a 6-ounce to 8-ounce cup of coffee, of caffeinated coffee a day had a meaningful risk reduction compared to non-coffee drinkers. And we found that dark flesh fish has a favorable prognostic factor. People eating frequent servings of tuna, mackerel, blue fish, salmon, fish that would be high in the kind of omega-3 oils that we think are helpful, also correlated with favorable outcome.