Q:

React Native FlatList Pagination not working - onEndReached doesn't fired

I am using react-native FlatList component to list of items
Pagination is not happening as expected , as per documentation onEndReached has to get fired when end of page is reached, currently I tried changing the values for onEndReachedThreshold ( tried 0.1, 1.0, 0.5, 0.01 ), am setting refreshing flag as well.
Note: I am using ReactNative 0.48.4
So here my code
<Container style={{ marginTop: 22 }}>
      <Content
        style={{ flex: 1 }}
        contentContainerStyle={{ flexGrow: 1 }}
      >
        <View style={{ flex: 1 }}>
          <FlatList
            initialNumToRender={10}
            refreshing={this.state.refreshing}
            onEndReachedThreshold={0.5}
            onEndReached={({ distanceFromEnd }) => {
              console.log('on end reached ', distanceFromEnd);
            }}
            data={this.props.messages}
            renderItem={this.notificationContent.bind(this)}
            keyExtractor={(item) => item._id}
          />
        </View>
      </Content>
    </Container>

I have already tried all possible solutions as give in responses for github issues
Any Help here ?

A:

You use NativeBase in your project and the Flatlist is on Content they are conflict. To solve this problem you need to remove Content

A:

Same thing happens with me you need to add contentContainerStyle={flex:1}
<Content contentContainerStyle={{ flex: 1 }}>


// Copyright 2017 Google Inc. All Rights Reserved.
//
// Licensed under the Apache License, Version 2.0 (the "License");
// you may not use this file except in compliance with the License.
// You may obtain a copy of the License at
//
//     http://www.apache.org/licenses/LICENSE-2.0
//
// Unless required by applicable law or agreed to in writing, software
// distributed under the License is distributed on an "AS IS" BASIS,
// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
// See the License for the specific language governing permissions and
// limitations under the License.

#include <iostream>
#include <fstream>
#include <map>
#include <string>
#include <gflags/gflags.h>

#include "disassembly/disassembly.hpp"
#include "disassembly/flowgraph.hpp"
#include "disassembly/flowgraphutil_dyninst.hpp"
#include "disassembly/pecodesource.hpp"
#include "util/util.hpp"

// A command-line tool that writes HTML files that allow the side-by-side
// visualisation of up to 6 different CFGs.
//
// The input string specifies triples of file-format, filename, address.
//
DEFINE_string(input, "ELF,/bin/tar,0x8BD0,ELF,/bin/gzip,0x2320", "...");
DEFINE_string(output, "/var/tmp/results.html", "Output html file.");

// The google namespace is there for compatibility with legacy gflags and will
// be removed eventually.
#ifndef gflags
using namespace google;
#else
using namespace gflags;
#endif

using namespace std;

int main(int argc, char** argv) {
  SetUsageMessage(
    "Writes interactive visualisation of CFGs into an HTML file.");
  ParseCommandLineFlags(&argc, &argv, true);

  printf("%s\n", FLAGS_input.c_str());
  // Read the visualization HTML template into an std::string.
  // TODO(thomasdullien): Make sure the executable can find the right
  // path?
  std::ifstream templatefile("../testdata/graph_template.html");
  std::string template_string((std::istreambuf_iterator<char>(templatefile)),
    std::istreambuf_iterator<char>());

  // Now obtain the JSON description of each of the functions specified in the
  // input string.
  std::vector<std::string> tokens = Tokenize(FLAGS_input.c_str(), ',');
  if ((tokens.size() % 3) != 0) {
    printf("[!] Invalid input command line argument (%d tokens).\n",
      tokens.size());
    exit(1);
  }

  std::vector<std::string> jsons;
  uint32_t tokens_index = 0;
  while (tokens_index < tokens.size()) {
    uint64_t address = strtoull(tokens[tokens_index + 2].c_str(), nullptr, 16);
    std::string result;
    bool res = GetCFGFromBinaryAsJSON(tokens[tokens_index],
      tokens[tokens_index+1], address, &result);
    if (!res) {
      printf("[!] Failed to load %s:%s:%s\n", tokens[tokens_index].c_str(),
        tokens[tokens_index+1].c_str(), tokens[tokens_index+2].c_str());
      exit(1);
    }
    printf("Got JSON for function!\n");
    tokens_index += 3;
    jsons.push_back(result);
    if (jsons.size() >= 6) {
      break;
    }
  }
  while (jsons.size() != 6) {
    jsons.push_back("");
  }

  // We have 6 JSON descriptions of the graph. Insert it into the template.
  std::vector<std::string> replacements( {
    "<!-- %%GRAPH0%% -->", "<!-- %%GRAPH1%% -->", "<!-- %%GRAPH2%% -->",
    "<!-- %%GRAPH3%% -->", "<!-- %%GRAPH4%% -->", "<!-- %%GRAPH5%% -->" } );
  for (uint32_t index = 0; index < 6; ++index) {
    size_t search_index = template_string.find(replacements[index]);
    if (search_index == std::string::npos) {
      printf("[!] Failed to find replacement string %s in template?\n",
        replacements[index].c_str());
    }
    template_string.replace(search_index, strlen(replacements[index].c_str()),
      jsons[index]);
  }

  std::ofstream html_file;
  html_file.open(FLAGS_output);
  html_file << template_string;
  html_file.close();
}


Surgical intensive care unit resource use in a specialty referral hospital: I. Predictors of early death and cost implications.
The rationing of medical care prioritizes the need for early predictors of death in the surgical intensive care unit (SICU). We prospectively studied 100 consecutive SICU admissions, looking for predictors of early death in the SICU and the cost implications of these findings. Serial APACHE II scores on days 1, 3, and 5 were subjected to multinomial logistic regression analysis to determine significant predictors of death in the SICU on day 1. Survivors had significantly lower (p less than 0.05) mean day-1 APACHE II scores than had nonsurvivors (13.6 vs 22.1). Half of the patients with scores greater than 18 died, and all patients with scores on day 1 of 25 or greater died. Significant predictors of death on SICU day 1 were APACHE II scores, Acute Physiology Score, Glasgow Coma Score, creatinine level, and Chronic Health Evaluation Score. Forty-one patients had been transferred from community hospitals as a results of acute illness; this population accounted for two thirds of the deaths in the SICU. Ten of 18 nonsurvivors were predicted on day 1, with these patients incurring a total cost of approximately $1 million. If therapy had been modified on days 5, 10, or 15, the potential cost savings would have been $340,000, $240,000, or $140,000, respectively. Integration of the results of this study into the management decision-making process and treatment guidelines may reduce the cost of care in the SICU.


Q:

GWT: Showing PDF created as POST response

I have a servlet in an GWT app thats creates a PDF file with the data given with the post request and sends the responst back:
public void service(HttpServletRequest request, HttpServletResponse response) {
        try {
            String text = request.getParameter("text");
            if (text == null || text.trim().length() == 0) {
                text = "no data";
            }

            //PDF Creation with iText
            Document document = new Document();
            ByteArrayOutputStream b = new ByteArrayOutputStream();
            PdfWriter.getInstance(document, b);
            document.open();
            document.add(new Paragraph(text));
            document.close();

            response.setHeader("Expires", "0");
            response.setHeader("Cache-Control",
                    "must-revalidate, post-check=0, pre-check=0");
            response.setHeader("Pragma", "public");
            response.setContentType("application/pdf");

            response.setContentLength(b.size());
            OutputStream os = response.getOutputStream();
            b.writeTo(os);
            os.flush();
            os.close();

        } catch (Exception ex) {
            System.out.println(ex.toString());
        }
    }

I want to show the created PDF to the User. I got this far on the client:
final RequestBuilder rb = new RequestBuilder(RequestBuilder.POST,
                GWT.getModuleBaseURL() + "PdfServlet");

    rb.setHeader("Content-type", "application/x-www-form-urlencoded");
    StringBuffer postData = new StringBuffer();
    postData.append(URL.encode("text")).append("=")
            .append(URL.encode(Text));

        rb.setRequestData(postData.toString());
        rb.setCallback(new RequestCallback() {

            @Override
            public void onResponseReceived(Request request,
                    Response response) {
                if (200 == response.getStatusCode()) {
                    //What to do here?
                } else {
                    //TODO:Something
                }
            }

            @Override
            public void onError(Request request, Throwable exception) {
                /TODO:...

            }
        });
        try {
            rb.send();
        } catch (RequestException e) {
            e.printStackTrace();
        }

So my question is:
How do I show this PDF to the user?
All i managaged to do is show the pdf with "no data" in it..
Thank you for you help :)

A:

Instead of using a RequestBuilder, you can simply use Window.Location.setUrl(yourDowloadUrl?key=value) and include your parameters in the query String. Note however that you must set the Content-disposition header: attachment header so the browser will prompt you to save or open the file, and not replace your GWT app.
Better even, create a hidden iframe in your html page, and call setUrl on that widget.
The downside of using this approach is that it doesn't allow your client code to capture feedback if something goes wrong server-side and instead of a pdf the call returns HTML with an error string from your web server. If that's very important to you, you should use a polling mechanism that requests the document, which is then produced and saved on the server, and checks every n seconds whether there is something to download. I have implemented something like this, which also prevents timeout issues with large documents. Let me know if you're interested

A:

you should create pdf file from your servlet and stored at somewhere on server. You need to return file path where you stored on the server. And now from GWT you can prompt window to user to download file. Below is the example for downloading file from GWT:
Window.open(GWT.getHostPageBaseURL() + your return path from server, "", "");


[Cytological diagnosis of lymphomatous papillary cystadenoma].
The cytologic material of 27 papillary cystadenoma was described. The thin needle aspiration procedure was performed. In 77.8% of cases the results were confirmed by histopathology.


[Left atrial thrombus simulating mitral stenosis].
The most common etiology of atrial mass, a rare disorder, is thrombosis. However, tumors, vegetations and fibrosis may also be responsible. Today, 2-dimensional echocardiography is the primary imaging technique for screening patients with a suspected cardiac mass. We describe a 66-year-old woman with chronic atrial fibrillation who was being treated with an anticoagulant for a year. A left atrial thrombus, which produced signs simulating those of mitral stenosis became dislodged and obstructed the abdominal aorta and superior mesenteric artery. She did not survive operation.


Efficient catalyst reuse by simple dissolution in non-conventional media.
This feature article is a description of the achievements made on the development of attractive sustainable approaches to synthetic organic chemistry, namely, catalyst reuse by simple dissolution in water and ionic liquids and asymmetric transformations induced by readily available chiral ionic liquids.


Demonstration of extrachromosomal DNA from Babesia equi merozoites.
An extrachromosomal nucleic acid element was detected in high-molecular-weight DNA preparations form Babesia equi merozoites. This extrachromosomal element was shown to be DNA rather than RNA and had an apparent fragment size of about 9 kilobase-pairs (kb). Hybridization experiments using purified 9-kb DNA as a probe revealed sequence homologies with extrachromosomal DNA from two other Babesia species.


framework module SSZipArchive {
  umbrella header "SSZipArchive-umbrella.h"

  export *
  module * { export * }
}


The official site of the SU chapter of NABJ

Main Menu

JRS

In honor of Black History Month, NABJ-SU members will acknowledge Journalists of Color, both past and present, who have broken ground to reshape the current landscape of practitioners in the field.

“Journalist Recognition Series: Jim Vance”

Born in Ardmore, Pennsylvania, Jim Vance probably never imagined he would be one of the faces of the evening news in the Nation’s Capital. Read his full biography here.

“Journalist Recognition Series: Robin Roberts”

Robin Roberts is the host of ABC’s “Good Morning America” and renowned American television broadcaster. Roberts started her on air broadcast career after obtaining a scholarship at Southeastern Louisiana University. At Southeastern Louisiana University, she was one of the most outstanding female basketball players in school history. Read her full biography here

“Journalist Recognition Series: Kathy Times”

Kathy Times is the President of Yellow Brick Media Concepts, a public relations, marketing campaign, and crisis communications firm. Previously, she served as the President and CEO of the National Association of Black Journalists.

Transitioning from print journalism after gaining her master’s degree from Northwestern University’s Medill School of Journalism… Read her full biography here

“Journalist Recognition Series: Ashley M. Williams”

In today’s media landscape, journalists are expected to dabble in multiple mediums. In the four short years since her graduation, Ashley M. Williams has developed a formula to innovatively cover journalistic stories, social media and entrepreneurship with the exact same accuracy.

“I have always been a curious person,” said the University of Southern California grad… Read her full biography here

“Journalist Recognition Series: Al Orendorff”

Like many college students, Al Orendorff did not stick with his initial major. He began in meteorology, but made the switch when he got a taste of the journalism pie. He worked in radio and television on campus at Illinois State University, where he earned a Bachelor of Science degree in Mass Communications in 1977…Read his full biography here

“Journalist Recognition Series: Mike Tirico”

Mike Tirico is currently an announcer on ESPN’s Monday Night Football. Former alumnus of Syracuse University, he graduated in 1988 and began his career working at Syracuse’s CBS affiliate WTVH-TV for four years.

Tirico moved directly to ESPN, becoming a SportsCenter anchor…Read his full biography here


Die letzte AMD & nVidia Grafikkarten-Roadmap stammt noch vom Februar, war somit (weit) vor dem Release von AMDs neuen Grafikkarten angelegt und beeinhaltet demzufolge auch noch nicht die Entwicklungen & Erkenntnisse rund um die inzwischen releasten neuen AMD- und nVidia-Grafikkarten. Jene wurden nun selbstverständlich in die neue Roadmap hinzugetragen – zuzüglich der wenigen noch zu erwartenden weiteren Grafikkarten aus der aktuellen 28nm-Ära. Faktisch kommen nun nur noch diverse Programmergänzungen – und danach der klare Schnitt mit den Beschleunigern der 14/16nm-Ära, was aber ein Thema des Jahres 2016 sein wird und wofür derzeit einfach noch zu wenige Informationen vorliegen. Insofern darf man diese Roadmap als abschließendes Dokument der 28nm-Ära betrachten – nachfolgende Roadmaps werden dann hoffentlich auch schon Informationen über die 14/16nm-Grafikchips enthalten. In der 28nm-Ära sind hingegen noch die folgenden Programmergänzungen zu erwarten:

Radeon R9 Fury X2

DualChip-Ausführung auf Basis des Fiji-Chips – Release: Herbst 2015

DualChip-Ausführung auf Basis des Fiji-Chips – Release: Herbst 2015 Radeon R9 Fury

abgepeckte Fiji-Variante mit Luftkühlung – Release: 14. Juli 2015

abgepeckte Fiji-Variante mit Luftkühlung – Release: 14. Juli 2015 Radeon R9 Nano

abgepeckte Fiji-Variante mit besonderen Augenmerk auf eine hohe Energieeffizienz – Release: drittes Quartal 2015

abgepeckte Fiji-Variante mit besonderen Augenmerk auf eine hohe Energieeffizienz – Release: drittes Quartal 2015 Radeon R7 360X, R7 370X & R9 380X

Vollausbau der Grafikchips Bonaire, Pitcairn und Tonga innerhalb der Radeon R300 Serie – Release: vermutlich Herbst/Winter 2015

Vollausbau der Grafikchips Bonaire, Pitcairn und Tonga innerhalb der Radeon R300 Serie – Release: vermutlich Herbst/Winter 2015 GeForce GT 940 & GTX 950

GM107-basierte Grafikkarten für die GeForce 900 Serie in Ersatz der (Chip-gleichen) GeForce GTX 750 & 750 Ti – Release: vermutlich Herbst/Winter 2015

GM107-basierte Grafikkarten für die GeForce 900 Serie in Ersatz der (Chip-gleichen) GeForce GTX 750 & 750 Ti – Release: vermutlich Herbst/Winter 2015 GeForce GTX 950 Ti

abgepeckte GM206-Variante für den Preisbereich um die 150 Dollar/Euro in Ersatz der GeForce GTX 660 – Release: vermutlich in den nächsten Wochen

abgepeckte GM206-Variante für den Preisbereich um die 150 Dollar/Euro in Ersatz der GeForce GTX 660 – Release: vermutlich in den nächsten Wochen GeForce GTX 960 Ti

nochmals abgespeckte GM204-Variante, um die sehr große Lücke zwischen GeForce GTX 960 & 970 zu füllen – Release: vermutlich Sommer/Herbst 2015

PS: Eine alternative Grafikkarten-Roadmap findet sich bei der PC Games Hardware.


Yes.  Thank you.

From: Tana Jones on 11/17/2000 09:28 AM
To: Lisa Lees/HOU/ECT@ECT, Stephanie Sever/HOU/ECT@ECT, Frank L
Davis/HOU/ECT@ECT
cc:
Subject: Contacts for Online Team in Legal

I thought this might be helpful.


Hepatotoxicity associated with antiretroviral therapy containing HIV-1 protease inhibitors.
Human immunodeficiency virus 1 (HIV-1) protease inhibitors are important components of highly active antiretroviral therapy and have had a profound impact on the natural history of HIV and AIDS. However, in the era of highly active antiretroviral therapy (HAART), drug-induced hepatotoxicity or liver injury has emerged as an important potential complication of combination antiretroviral therapy, particularly those regimens containing protease inhibitors (PIs). Liver injury has been associated each of the six PIs currently approved by the U. S. Food and Drug Administration (FDA), most commonly with administration of full dose ritonavir (600 mg bid or 400 mg bid with saquinavir). However, this regimen has been largely replaced by the use of low-dose ritonavir (</= 200 mg bid) to pharmacologically "boost" other PI, such as lopinavir or indinavir, which has not been associated with an increased risk of hepatotoxicity compared with other PIs. Coinfection with hepatitis C virus (HCV) and B virus (HBV) remains an important risk factor for the development of HAART-associated liver injury. Although studies indicate that coinfected patients can be safely treated with PIs, such patients should be closely monitored. In addition, although unsubstantiated, some experts recommend evaluation or treatment, or both, of underlying chronic viral hepatitis prior to the initiation of antiretroviral therapy. Further research is needed to understand the etiopathogenesis of PI-associated liver injury, particularly among patients with hepatitis B or C infection.


Mayor of London outlines major EV infrastructure expansion as 2030 target set

EV charging infrastructure in London is to undergo a major expansion, including five flagship charging hubs, in a bid for zero emission transport by 2030.

The Mayor of London, Sadiq Khan, has laid out plans for an ‘electric revolution’ of London’s transport in line with ambitions for the capital to be one of the world’s leading zero-emission cities.

Five flagship charging hubs are to be introduced, the first of which will be operational in Square Mile by the end of 2019.

A ‘one-stop-shop’ for Londoners to request new charging infrastructure from local authorities will also be led by London councils, with the aim of making the switch to EVs easier.

Fast charging at one of the dozen rapid chargers at Stanmore – before they were removed (Image: T. Larkum)

Next generation ultra-rapid charging points are to be installed at London petrol stations later in the year, with 300 rapid chargers to be installed by the end of next year. There will also be a focus on expanding car clubs and bringing more vehicles to the market.

A new electric van, based on the electric black cab, has also been unveiled by the London Electric Vehicle Company, going on sale next year.

Sir John Armitt, chair of the National Infrastructure Commission, said whilst launch of the van and rapid chargers highlights the importance of EVs in improving air quality and reducing the impact of the growth in urban freight, the government should commit to a national rapid charging network.

“More action will needed– such as the ban on new diesel HGV sales by 2040 we recommended in our recent report on freight and reinforcing the electricity network – if we’re to meet the UK’s climate change targets and clean up the air in London and other cities,” Armitt added.


Outside Providence

Outside Providence may refer to:

Outside Providence, a 1988 novel
Outside Providence, a 1999 film based on the novel


1992 United States presidential election in New Hampshire

The 1992 United States presidential election in New Hampshire took place on November 3, 1992, as part of the 1992 United States presidential election. Voters chose 4 representatives, or electors to the Electoral College, who voted for president and vice president.

New Hampshire was won by Governor Bill Clinton (D-Arkansas) with 38.91% of the popular vote over incumbent President George H.W. Bush (R-Texas) with 37.69%. Businessman Ross Perot (I-Texas) finished in third, with 22.59% of the popular vote. Clinton ultimately won the national vote, defeating incumbent President Bush.

Clinton's win marked the beginning of a dramatic shift in New Hampshire politics toward the Democratic Party. The state had previously been regarded as a conservative Republican bastion; just four years earlier Bush had carried the state with over 60% of the vote. The last time a Democrat had won the state was Lyndon Johnson in 1964 United States presidential election in New Hampshire. But like the rest of New England, New Hampshire began trending hard toward the left in the 1990s, and since 1992 the state has voted Democratic in every presidential election except 2000.

News networks projected the elections in New Hampshire, Georgia, and New Jersey for Bill Clinton before getting results for either of the said states, all of which voted for Bill Clinton by less than 2.5%, which means their projections were nearly inaccurate. In fact, news networks projected the elections in states with a total of 300 electoral votes for Bill Clinton as soon as their polls closed, which was enough to win the whole presidency.

Primaries

Democratic primary
The 1992 New Hampshire Democratic primary was won by Paul Tsongas, but is known for the insurgent campaign of Bill Clinton, who managed a surprising second-place finish. It was held February 18, 1992.

The Iowa caucus, the first contest of the 1992 Democratic primaries, was not contested.  Due to the presence of Iowa Senator Tom Harkin in the race, the other candidates did not campaign in Iowa, instead conceding the contest to Harkin, and making the New Hampshire primary even more important.

On January 19, The Boston Globe published a poll showing Clinton ahead of the field with 29%, Paul Tsongas with 17%, and Bob Kerrey 16%.  Following this poll, reports of an extramarital affair between Clinton and Gennifer Flowers surfaced. As Clinton fell far behind former Massachusetts Senator Paul Tsongas in the New Hampshire polls, Clinton and his wife Hillary went on 60 Minutes following the Super Bowl to deny the charges. The Clinton campaign also weathered attacks concerning alleged draft dodging during the Vietnam War and the case of Ricky Ray Rector.

Tsongas won the New Hampshire primary with Clinton finishing within single digits of Tsongas, despite trailing badly in the polls.  Since many expected Tsongas to win anyway, as New Hampshire borders his home state of Massachusetts, the media viewed the results as a victory for Clinton. On election night, Clinton labeled himself "The Comeback Kid" and left New Hampshire with an increase in momentum in the remaining primaries, which helped him win the nomination.  Clinton became the first president elected despite not winning the New Hampshire primary, a feat since duplicated by George W. Bush in 2000 and Barack Obama in 2008.

Results
Paul Tsongas: 55,666 (33.21%)
Bill Clinton: 41,542 (24.78%)
Bob Kerrey: 18,584 (11.09%)
Tom Harkin: 17,063 (10.18%)
Jerry Brown: 13,660 (8.15%)
Mario Cuomo: 6,577 (3.92%)
Tom Laughlin: 3,251 (1.94%)
Ralph Nader: 3,054 (1.82%)
Charles Woods: 2,862 (1.71%)
George Herbert Walker Bush: 1,433 (0.86%)
Pat Buchanan: 1,248 (0.74%)
Lenora Fulani: 402 (0.24%)
Larry Agran: 331 (0.20%)
Patrick J. Mahoney, Jr.: 303 (0.18%)
Eugene McCarthy: 211 (0.13%)
John Donald Rigazio: 186 (0.11%)
Curly Thornton: 125 (0.08%)
Lyndon LaRouche: 115 (0.07%)
Douglas Wilder: 103 (0.06%)
Caroline Killeen: 94 (0.06%)
John Patrick Cahill: 83 (0.05%)
Paul C. Fisher: 82 (0.05%)
Andre Marrou: 67 (0.04%)
Frank Bona: 65 (0.04%)
Karl J. Hegger: 61 (0.04%)

''Source: Our Campaigns

Results

References

New Hampshire
1992
United States President
Category:Bill Clinton


Georgetown County School District

Georgetown County School District is a school district serving Georgetown County, South Carolina, United States. It is based in  Georgetown, South Carolina.
H. Randall Dozier has been the superintendent since 2003.

Schools

Elementary schools
Andrews Elementary School
Brown's Ferry Elementary School
Kensington Elementary School
Maryville Elementary School
McDonald Elementary School
Plantersville Elementary School
Pleasant Hill Elementary School
Sampit Elementary School
Waccamaw   Elementary School

Intermediate school
Waccamaw Intermediate School

Middle schools
Carvers Bay Middle School
Georgetown Middle School
Rosemary Middle School
Waccamaw Middle School

High schools
Andrews High School
Carvers Bay High School
Georgetown High School
Waccamaw High School

Adult education
Howard Adult Center

Historic Schools
Howard High School
Winyah High School
J.B. Beck Middle School

External links

Category:School districts in South Carolina
*


BHOPAL: The CBI team which is in Gwalior to investigate Vyapam scam has accused state government of non-cooperation. Two months after the probe was handed over to CBI, the agency does not have a proper office in the city to carry out its operations.

On Wednesday, deputy superintendent of police, CBI told Gwalior bench of high court that water resources department has locked 2 rooms of its four-room rest house given to them as office. Now, CBI has been asked to move out and open an office in Tighra, a dam site 30 kms from the city.

During hearing of a Vyapam case, when DSP CBI Rajeev Chandola told these problems to a division bench of justice UC Maheshweri and SK Gupta, judges asked the investigating agency to submit its complaints on an affidavit for further action.

Chandola also told the court that an engineer of water resources department has locked two rooms of their office claiming that the department needed them in view of the upcoming Rabi season. He also showed judges a photo of the engineer clicked from his phone.

“Now, how many officers will sit in two rooms and how would they interrogate people and hold investigations,” he told the division bench.

Later talking to TOI, additional solicitor general Vivek Khedker said, “The district collector and the additional advocate general have asked CBI to move out to Tighra. It is far away from the city and there are security issues.”

He said that the court asked us to file an affidavit if the issue is not resolved in the next few days.

The CBI has told the court there are 37 Vyapam cases in Gwalior and Chambal region but the premier agency does not have enough resources. During a recent visit of Pankaj Kamboj, an SP, a taxi was made available for him. Vehicles provided to the agency are old and create trouble while commuting in the city.

CBI sources also said that the administration is also exerting pressure to vacate hostel rooms allotted to it in Agriculture University in Gwalior.

Sources also said that the bungalow allocated to the investigating agency in Bhopal has also not been furnished fully which is delaying the investigations.


Well water contamination in a rural community in southwestern Pennsylvania near unconventional shale gas extraction.
Reports of ground water contamination in a southwestern Pennsylvania community coincided with unconventional shale gas extraction activities that started late 2009. Residents participated in a survey and well water samples were collected and analyzed. Available pre-drill and post-drill water test results and legacy operations (e.g., gas and oil wells, coal mining) were reviewed. Fifty-six of the 143 respondents indicated changes in water quality or quantity while 63 respondents reported no issues. Color change (brown, black, or orange) was the most common (27 households). Well type, when known, was rotary or cable tool, and depths ranged from 19 to 274 m. Chloride, sulfate, nitrate, sodium, calcium, magnesium, iron, manganese and strontium were commonly found, with 25 households exceeding the secondary maximum contaminate level (SMCL) for manganese. Methane was detected in 14 of the 18 houses tested. The 26 wells tested for total coliforms (2 positives) and E. coli (1 positive) indicated that septic contamination was not a factor. Repeated sampling of two wells in close proximity (204 m) but drawing from different depths (32 m and 54 m), revealed temporal variability. Since 2009, 65 horizontal wells were drilled within a 4 km (2.5 mile) radius of the community, each well was stimulated on average with 3.5 million gal of fluids and 3.2 million lbs of proppant. PA DEP cited violations included an improperly plugged well and at least one failed well casing. This study underscores the need for thorough analyses of data, documentation of legacy activity, pre-drill testing, and long term monitoring.


Do you like what you just read?

Trump: Russian hacks 'had no effect on election'

President-elect Trump said in a statement today, after being briefed by President Obama’s top intelligence advisors, that the supposed hack by Russia had no effect whatsoever on the outcome of the presidential election. "While Russia, China, other countries, outside groups and people are consistently trying to break through the cyber infrastructure of our governmental institutions, businesses and organizations including the Democratic National Committee, there was absolutely no effect on the outcome of the election including the fact that there was no tampering whatsoever with voting machines," Trump said in a statement.

Democrats and the Obama administration, as well as some Republicans, have concurred with the intelligence community's conclusion that Russia sought to turn the election in Trump’s favor.

"There were attempts to hack the Republican National Committee, but the RNC had strong hacking defenses and the hackers were unsuccessful," he declared. Trump did not mention whether Russia had hacked into Democratic emails, or whether Russia had any connection to the release of the emails by the WikiLeaks organization.

The meeting with the intelligence officials was "constructive," said Trump who added that he has "tremendous respect" for the work carried out by the various intelligence agencies, which include the National Security Agency, the Central Intelligence Agency, and the Defense Intelligence Agency.

Trump said he will work towards eliminating future cyberattacks after he becomes president. "I will appoint a team to give me a plan within 90 days of taking office," he said. "The methods, tools and tactics we use to keep America safe should not be a public discussion that will benefit those who seek to do us harm. Two weeks from today I will take the oath of office and America's safety and security will be my number one priority."


Use of Lactococcus lactis as a production system for peptides and enzymes encoded by a Lantibiotic gene cluster from Bifidobacterium longum.
Bifidobacterium longum DJO10A was previously demonstrated to be able to produce a broad-spectrum lantibiotic, but production in media was very limited and only periodically on solid media. Given the difficulty of obtaining these lantibiotic peptides using B. longum DJO10A due to its tightly controlled production, genes predicted to be required for its production and immunity were designed and codon optimized according to the preferred codon used by Lactococcus lactis. Since the lanR1 gene within this lantibiotic gene cluster was the only one without a characterized analogue from other lantibiotic gene clusters, its annotation was re-examined as it was previously suggested to be a regulatory protein. Lack of DNA binding motifs did not support this, and one current analysis suggested a high likelihood of it interacting with LanD. Therefore, gene lanR1 together with lanADMIT were codon optimized and synthesized. Those genes were then cloned into an efficient dual-plasmid nisin-controlled expression system in L. lactis. The addition of the lanR1 gene exhibited toxicity in E. coli, specifically causing a shorter cell size as observed by SEM. No toxicity was observed in L. lactis. While this production system did not result in the production of a bioactive lantibiotic by L. lactis, it did successfully produce all the peptides and enzymes encoded by the original lantibiotic gene cluster from B. longum, as confirmed by LC-MS. This will now facilitate efforts into determining the proper conditions required for these enzymes to produce a bioactive lantibiotic.


Since we didn’t have a first-run episode of Scandal last week — something about a holiday? — this is a good time to stop and cast our best guesses for this coming Thursday’s mid-season finale. A few questions to get us started, based on our last visit with our group of antiheroes and villains:

We got the first glimpse of the reunion between Olivia and Mrs. Pope. Will we finally get to hear what she could have done to “merit” being thrown in a secret underground prison — by her husband?

Cyrus’ plan to offer up James as bait for a scandal seems to have worked too well. Even if James didn’t fall into the arms of Daniel Langston, what’s the fallout likely to be? And how much does Sally know about her husband’s activities?

Quinn earned her burn notice less than a week after becoming a spy. Worst of all, now she’s apparently going to be on the wrong end of a Huck interrogation. What’s the odds Charlie intercedes and sets up a fight for the soul of “Robin”?

To the chagrin of most of America, Fitz made his biggest pitch yet for keeping Olivia — her own White Hat House out in the boonies. Problem for him is, Mellie knows (if not about the house, then about their latest tryst). How willing is Mellie to upend his re-election bid by arranging for Olivia to join the team?

Who’s the clubhouse favorite for the death pool this season? My money’s still on Harrison, given the sudden amount of attention he’s been getting, with Jake a close second; somebody will have to “pay a price” for all this B613 business.

Racializens, the floor is yours. How do you see this show taking us into the winter break?

Olivia (Kerry Washington) and Fitz (Tony Goldwyn) indulge in a shared future for one night.

Score this round for the (relatively) good guys.

In the last episode before the winter finale, we saw the pieces begin to move. While Olivia and Fitz’s dalliance in the house revealed just how far Fitz’s obsession flame went — not to mention how badly he seems to want out of politics — the duo also came to an understanding, if not an outright alliance. Each would do what they had to do to unravel Eli and B613.

It’s possible Shonda Rhimes, writer Peter Nowalk and the Scandal creative team intended for Mellie to dominate the water-cooler talk after this episode, and explicitly set out to “out-do” not just Quinn’s descent into B613’s clutches, but the confirmation that Olivia’s mother is still alive and Fitz’s realization that Olivia’s father is the man atop B613.

It’s also apparent that they succeeded. But not without going to a highly questionable place.

Unbeknownst to her, Young Olivia (Yara Shahidi) bids her mother Maya (Khandi Alexander) her final goodbye.

The thing is, Cyrus is almost right: This season is shaping up to be Scandal‘s version of “a Greek tragedy in the making.” He just doesn’t realize how far that could spread. He also forgets to mention that in the story that gives this episode its’ title, Icarus didn’t meet his fate entirely on his own — he does so with the tools someone else provided for him.Continue reading →

The Road to the White House now appears to literally go through Olivia (Kerry Washington) on “Scandal.”

Give writer Jenna Bans credit: “More Cattle, Less Bull” justified its’ rather fast clip by successfully showing why this show’s distaff circles have no choice but to stick around each other. It also delivers a major reversal of fortune for Olivia’s career, just in time for what will probably instigate the final battle with her father.Continue reading →

With the combined fire power of a few cute empire waists, boxy tops, and racial stereotypes, Kerry Washington became one of a handful of Black women to host Saturday Night Live in its 30+ year history. Given the recent controversy surrounding the lack of color in the SNL cast, its understandable that the show would be eager to face the topic head on. Asking Washington to host was a nice first step, but they seem content to stop there.

Scrolling text in Kerry Washington’s SNL cold open, via Mashable

Sure, SNL addressed their lack of Black women directly in the cold open, but joking about the glaring absence really loses all effectiveness if you don’t take steps to fix it immediately after. Addressing your own racist casting practices as a joke makes you seem less like a writer’s room full of subversive humourist savants than it does a room full of white privileged writers. The screen caps above represent a joke that could only retain legs if at the end of the show they’d announced the addition of a full time Black female cast member.

Of course, after seeing the sketches Washington was thrown into –especially in the first half of the show– it’s probably worth wondering how well a Black woman would fare in this era of SNL. With a sketches that included a mouthy, angry Black girlfriend, a BAPs style Black ghetto girl, an Ugandan beauty queen who reeked of Eddie Murphy’s “what have you done for me lately” bit from Raw, and the best Angela Davis impression she could muster, Washington and the SNL writers were one weave joke away from a stereotypical Black woman full sweep.

Washington put her all into everything she was given (as did Jay Pharoah, who was in all but 2 sketches on Saturday night, “because,” said the writer’s room, “if they want Black people then, goddamnit, we are going to give them black people! Take that, critics.”) but surely there have been several other hosts from popular breakout television shows who’ve knocked their hosting nights out of the park without relying on racial humour to take them through. Jon Hamm comes to mind. Unfortunately, where someone like Jon Hamm seems to inspire new, original material, the SNL writers room looked at Kerry Washington and clearly decided that with the plethora of jokes people have been making about Black women for years, they already had all they needed.

The only sketch that seemed as if it had any input from a non white writer included the Angela Davis impression mentioned above. I really do wish my white friends would stop telling me to watch The Wire. But for the most part, I still have to disagree with Kenan Thompson’s recent comments about there being no Black female comedians who are ready for SNL. It’s the SNL writers who aren’t ready for Black women.

The rest of Saturday night’s sketches are underneath the cut. What do you think, readers?

Race, Culture, and Identity in a Colorstruck World

About This Blog

Racialicious is a blog about the intersection of race and pop culture. Check out our daily updates on the latest celebrity gaffes, our no-holds-barred critique of questionable media representations, and of course, the inevitable Keanu Reeves John Cho newsflashes.

Latoya Peterson (DC) is the Owner and Editor (not the Founder!) of Racialicious, Arturo García (San Diego) is the Managing Editor, Andrea Plaid (NYC) is the Associate Editor. You can email us at team@racialicious.com.


Advancing digital methods in the fight against communicable diseases.
Important advances are being made in the fight against communicable diseases by using new digital tools. While they can be a challenge to deploy at-scale, GPS-enabled smartphones, electronic dashboards and computer models have multiple benefits. They can facilitate program operations, lead to new insights about the disease transmission and support strategic planning. Today, tools such as these are used to vaccinate more children against polio in Nigeria, reduce the malaria burden in Zambia and help predict the spread of the Ebola epidemic in West Africa.


Double "Open and Shut" Transformation of γ-Carbolines Triggered by Ammonium Salts: One-Pot Synthesis of Multiheterocyclic Compounds.
A novel cascade reaction of indole-2,3-epoxide equivalents with γ-carbolines by utilizing a double "open and shut" transformation to access multiheterocyclic compounds containing both isotryptamines and pyrimido[1,6- a]indoles has been developed. This strategy utilizes the in situ formation of a bulky quaternary ammonium salt via ammonium exchange, which undergoes Hofmann elimination/vinylogous Mannich/retro-Mannich/cyclization cascade sequences.


Related literature {#sec1}
==================

For crystallographic data of tetrakis(pyridin-2-yl-methyl)alkyl-diamine compounds, see: Fujihara *et al.* (2004[@bb9]); Mambanda *et al.* (2007[@bb10]). For the superoxide dismutase activity of iron complexes, see: Tamura *et al.* (2000[@bb12]). For dinuclear Pt complexes of similar ligands, see: Ertürk *et al.* (2007[@bb8]). For the use of the dipicolylamine moiety for binding of the *M*(CO)~3~ core (*M* = Re,^99*m*^Tc), see: Bartholomä *et al.* (2009[@bb5]). For crystal structures closely related to the title compound, see: Bartholomä *et al.* (2010*a* [@bb2],*b* [@bb3],*c* [@bb4],*d* [@bb1]).

Experimental {#sec2}
============

 {#sec2.1}

### Crystal data {#sec2.1.1}

\[Cu~2~Br~4~(C~28~H~32~N~6~)\]*M* *~r~* = 899.32Monoclinic,*a* = 8.8613 (6) Å*b* = 14.249 (1) Å*c* = 11.9488 (9) Åβ = 98.588 (2)°*V* = 1491.80 (18) Å^3^*Z* = 2Mo *K*α radiationμ = 6.81 mm^−1^*T* = 90 K0.18 × 0.12 × 0.08 mm

### Data collection {#sec2.1.2}

Bruker APEX CCD diffractometerAbsorption correction: multi-scan (*SADABS*; Bruker, 1998[@bb7]) *T* ~min~ = 0.374, *T* ~max~ = 0.61214513 measured reflections3623 independent reflections3171 reflections with *I* \> 2σ(*I*)*R* ~int~ = 0.052

### Refinement {#sec2.1.3}

*R*\[*F* ^2^ \> 2σ(*F* ^2^)\] = 0.074*wR*(*F* ^2^) = 0.147*S* = 1.383623 reflections181 parametersH-atom parameters constrainedΔρ~max~ = 1.38 e Å^−3^Δρ~min~ = −0.85 e Å^−3^

 {#d5e459}

Data collection: *SMART* (Bruker, 1998[@bb7]); cell refinement: *SAINT* (Bruker, 1998[@bb7]); data reduction: *SAINT*; program(s) used to solve structure: *SHELXS97* (Sheldrick, 2008[@bb11]); program(s) used to refine structure: *SHELXL97* (Sheldrick, 2008[@bb11]); molecular graphics: *DIAMOND* (Brandenburg & Putz, 1999[@bb6]); software used to prepare material for publication: *SHELXTL* (Sheldrick, 2008[@bb11]).

Supplementary Material
======================

Crystal structure: contains datablocks I, global. DOI: [10.1107/S1600536810034537/lh5106sup1.cif](http://dx.doi.org/10.1107/S1600536810034537/lh5106sup1.cif)

Structure factors: contains datablocks I. DOI: [10.1107/S1600536810034537/lh5106Isup2.hkl](http://dx.doi.org/10.1107/S1600536810034537/lh5106Isup2.hkl)

Additional supplementary materials: [crystallographic information](http://scripts.iucr.org/cgi-bin/sendsupfiles?lh5106&file=lh5106sup0.html&mime=text/html); [3D view](http://scripts.iucr.org/cgi-bin/sendcif?lh5106sup1&Qmime=cif); [checkCIF report](http://scripts.iucr.org/cgi-bin/paper?lh5106&checkcif=yes)

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: [LH5106](http://scripts.iucr.org/cgi-bin/sendsup?lh5106)).

This work was supported by funding from Syracuse University.

Comment
=======

The described ligand *N^1^*,*N^1^*,*N^4^*,*N^4^*-tetrakis(pyridin-2-ylmethyl)butane-1,4-diamine has been used as starting material for hydrothermal synthesis of metal-organic transition metal/molybdateoxide frameworks in the principal author\'s laboratory (Bartholomä, unpublished results). The dipicolylamine moiety has originally been used in our laboratory as metal chelating entity for binding of the *M*(CO)~3~ core (*M* = Re,^99^*^m^*Tc) for radiopharmaceutical purposes. A different coordination mode has been observed for the *M*(CO)~3~ core in which the dipicolylamine metal chelate is coordinated in a facial manner (Bartholomä, 2009).

The title complex was prepared as part of a series with different cadmium and copper salts to study the coordination properties of the ligand with these metals without the interaction of metaloxide clusters (Bartholomä, 2010*a*,b,c). The crystalline sample obtained with copper chloride as metal source and *N^1^*,*N^1^*,*N^5^*,*N^5^*-tetrakis(pyridin-2-ylmethyl)pentane-1,5-diamine gave a structurally similar compound with a distorted square pyramidal coordination geometry of the copper atoms as observed for the described complex. The Cu---N~py~ distances of 1.986 (4) Å and 1.996 (4), and a Cu---N*~tert~* distance of 2.076 (4) Å (Bartholomä, 2010d).

Crystal structures of the ligands *N^1^*,*N^1^*,*N^3^*,*N^3^*-tetrakis(2-pyridiniomethyl)-1,3-diaminopropane and *N^1^*,*N^1^*,*N^4^*,*N^4^*-tetrakis(pyridin-2-ylmethyl)butane-1,4-diamine have been described recently (Fujihara, 2004; Mambanda, 2007). Superoxide dismutase activity of iron(II) complexes of *N^1^*,*N^1^*,*N^3^*,*N^3^*-tetrakis(2-pyridiniomethyl)-1,3-diaminopropane and related ligands has been investigated by Tamura *et al.* (2000). Studies on the thermodynamic and kinetic behaviour of the reaction of platinum(II) complexes of higher ligand homologues with chloride have been performed by Ertürk *et al.* (2007).

Experimental {#experimental}
============

*N^1^*,*N^1^*,*N^4^*,*N^4^*-tetrakis(pyridin-2-ylmethyl)butane-1,4-diamine. An amount of 1.00 g (11.34 mmol) 1,4-diaminobutane was dissolved in 30 ml anhydrous dichloroethane under an inert atmosphere (argon) followed by the addition of 4.55 ml (47.65 mmol) pyridine-2-carboxaldehyde. The mixture was stirred for 15 min at r.t. and then cooled with an ice bath prior to the portionwise addition of 14.43 g (68.06 mmol) sodium triacetoxyborohydride (gas evolution, exothermic reaction). The reaction was stirred overnight allowing the temperature slowly to rise to room temperature. The reaction was quenched by the dropwise addition of saturated sodium bicarbonate solution and stirring was continued until the gas evolution ceased. The mixture was separated and the organic layer was further washed with saturated sodium bicarbonate solution, water and brine. The organic phase was dried with anhydrous sodium sulfate, filtered and the solvent removed under reduced pressure. The crude reaction mixture was then purified by silica gel column chromatography starting with chloroform and increasing gradient to chloroform:methanol 10:1 (*v*/*v*). Yield: 4.02 g (78%). ^1^H NMR (CDCl~3~): *δ* = 8.40 (m, 4H), 7.51 (m, 4H), 7.39 (d, J = 7.81 Hz, 4H), 7.02 (m, 4H), 3.67 (s, 8H), 2.39 (m, 4H), 1.42 (m, 4H) p.p.m..

Synthesis of metal complex. To 2 ml of an aqueous solution of copper bromide, two equivalents (50 mg, 0.11 mmol) of *N^1^*,*N^1^*,*N^4^*,*N^4^*-tetrakis(pyridin-2-ylmethyl)butane-1,4-diamine in 2 ml methanol were added followed by the addition of 2 ml *N*,*N*-dimethylformamide. Single crystals were obtained after a week by slow evaporation of the solvents at room temperature.

Refinement {#refinement}
==========

All the H atoms were placed in idealized positions and refined in a riding-model approximation with *C*---H~aryl~ = 0.95 Å, *C*---H~methyl~ = 0.98Å and *C*---H~methylene~ = 0.99Å and *U*~iso~(H) = 1.5*U*~eq~(C~methyl~) and 1.2*U*~eq~(C~methylene/aryl~).

Figures
=======

![The crystal structure of the title complex. The displacement ellipsoids are drawn at 50% probability level. Hydrogen atoms are omitted for clarity. Unlabeled atoms are related by the symmetry code (-x + 1, -y + 1, -z + 1).](e-66-m1198-fig1){#Fap1}

Crystal data {#tablewrapcrystaldatalong}
============

  -------------------------------- ---------------------------------------
  \[Cu~2~Br~4~(C~28~H~32~N~6~)\]   *F*(000) = 880
  *M~r~* = 899.32                  *D*~x~ = 2.002 Mg m^−3^
  Monoclinic, *P*2~1~/*n*          Mo *K*α radiation, λ = 0.71073 Å
  Hall symbol: -P 2yn              Cell parameters from 2666 reflections
  *a* = 8.8613 (6) Å               θ = 2.7--27.2°
  *b* = 14.249 (1) Å               µ = 6.81 mm^−1^
  *c* = 11.9488 (9) Å              *T* = 90 K
  β = 98.588 (2)°                  Plates, green
  *V* = 1491.80 (18) Å^3^          0.18 × 0.12 × 0.08 mm
  *Z* = 2
  -------------------------------- ---------------------------------------

Data collection {#tablewrapdatacollectionlong}
===============

  ------------------------------------------------------------ --------------------------------------
  Bruker APEX CCD diffractometer                               3623 independent reflections
  Radiation source: fine-focus sealed tube                     3171 reflections with *I* \> 2σ(*I*)
  graphite                                                     *R*~int~ = 0.052
  Detector resolution: 512 pixels mm^-1^                       θ~max~ = 28.1°, θ~min~ = 2.2°
  φ and ω scans                                                *h* = −10→11
  Absorption correction: multi-scan (*SADABS*; Bruker, 1998)   *k* = −18→18
  *T*~min~ = 0.374, *T*~max~ = 0.612                           *l* = −15→15
  14513 measured reflections
  ------------------------------------------------------------ --------------------------------------

Refinement {#tablewraprefinementdatalong}
==========

  ------------------------------------- -------------------------------------------------------------------------------------------------
  Refinement on *F*^2^                  Primary atom site location: structure-invariant direct methods
  Least-squares matrix: full            Secondary atom site location: difference Fourier map
  *R*\[*F*^2^ \> 2σ(*F*^2^)\] = 0.074   Hydrogen site location: inferred from neighbouring sites
  *wR*(*F*^2^) = 0.147                  H-atom parameters constrained
  *S* = 1.38                            *w* = 1/\[σ^2^(*F*~o~^2^) + (0.042*P*)^2^ + 10.8322*P*\] where *P* = (*F*~o~^2^ + 2*F*~c~^2^)/3
  3623 reflections                      (Δ/σ)~max~ = 0.001
  181 parameters                        Δρ~max~ = 1.38 e Å^−3^
  0 restraints                          Δρ~min~ = −0.85 e Å^−3^
  ------------------------------------- -------------------------------------------------------------------------------------------------

Special details {#specialdetails}
===============

  -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
  Geometry. All e.s.d.\'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.\'s are taken into account individually in the estimation of e.s.d.\'s in distances, angles and torsion angles; correlations between e.s.d.\'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.\'s is used for estimating e.s.d.\'s involving l.s. planes.
  Refinement. Refinement of *F*^2^ against ALL reflections. The weighted *R*-factor *wR* and goodness of fit *S* are based on *F*^2^, conventional *R*-factors *R* are based on *F*, with *F* set to zero for negative *F*^2^. The threshold expression of *F*^2^ \> σ(*F*^2^) is used only for calculating *R*-factors(gt) *etc*. and is not relevant to the choice of reflections for refinement. *R*-factors based on *F*^2^ are statistically about twice as large as those based on *F*, and *R*- factors based on ALL data will be even larger.
  -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å^2^) {#tablewrapcoords}
==================================================================================================

  ------ -------------- ------------- ------------- -------------------- --
         *x*            *y*           *z*           *U*~iso~\*/*U*~eq~
  Cu1    0.35669 (10)   0.75522 (6)   0.35899 (7)   0.0111 (2)
  Br1    0.21437 (9)    0.82045 (5)   0.15805 (6)   0.01711 (19)
  Br2    0.29274 (9)    0.87831 (5)   0.48204 (6)   0.01847 (19)
  N1     0.4360 (6)     0.6374 (4)    0.2878 (5)    0.0087 (11)
  N2     0.1789 (7)     0.6693 (4)    0.3702 (5)    0.0101 (11)
  N3     0.5695 (6)     0.8000 (4)    0.3456 (5)    0.0099 (11)
  C1     0.2983 (8)     0.5899 (5)    0.2279 (6)    0.0138 (14)
  H1A    0.3214         0.5230        0.2157        0.017\*
  H1B    0.2676         0.6195        0.1530        0.017\*
  C2     0.1707 (8)     0.5972 (5)    0.2964 (6)    0.0118 (13)
  C3     0.0522 (8)     0.5333 (5)    0.2869 (6)    0.0161 (15)
  H3     0.0470         0.4837        0.2334        0.019\*
  C4     −0.0587 (9)    0.5423 (5)    0.3564 (7)    0.0208 (16)
  H4     −0.1415        0.4994        0.3507        0.025\*
  C5     −0.0474 (9)    0.6153 (6)    0.4350 (7)    0.0214 (16)
  H5     −0.1201        0.6219        0.4854        0.026\*
  C6     0.0718 (8)     0.6775 (5)    0.4377 (6)    0.0159 (14)
  H6     0.0784         0.7284        0.4896        0.019\*
  C7     0.5359 (8)     0.6749 (5)    0.2094 (6)    0.0136 (14)
  H7A    0.4729         0.7002        0.1406        0.016\*
  H7B    0.6010         0.6242        0.1863        0.016\*
  C8     0.6340 (8)     0.7514 (5)    0.2682 (6)    0.0132 (14)
  C9     0.7788 (9)     0.7733 (5)    0.2435 (6)    0.0169 (15)
  H9     0.8206         0.7398        0.1866        0.020\*
  C10    0.8606 (8)     0.8445 (5)    0.3033 (6)    0.0167 (15)
  H10    0.9603         0.8600        0.2890        0.020\*
  C11    0.7950 (9)     0.8930 (5)    0.3845 (6)    0.0186 (15)
  H11    0.8492         0.9421        0.4267        0.022\*
  C12    0.6489 (9)     0.8689 (5)    0.4032 (6)    0.0147 (14)
  H12    0.6041         0.9024        0.4587        0.018\*
  C13    0.5282 (8)     0.5732 (5)    0.3704 (6)    0.0111 (13)
  H13A   0.6209         0.6073        0.4052        0.013\*
  H13B   0.5620         0.5193        0.3281        0.013\*
  C14    0.4471 (7)     0.5353 (4)    0.4650 (5)    0.0096 (13)
  H14A   0.3506         0.5042        0.4323        0.011\*
  H14B   0.4224         0.5875        0.5139        0.011\*
  ------ -------------- ------------- ------------- -------------------- --

Atomic displacement parameters (Å^2^) {#tablewrapadps}
=====================================

  ----- ------------ ------------ ------------ ------------- ------------ -------------
        *U*^11^      *U*^22^      *U*^33^      *U*^12^       *U*^13^      *U*^23^
  Cu1   0.0124 (4)   0.0090 (4)   0.0126 (4)   0.0003 (3)    0.0041 (3)   −0.0005 (3)
  Br1   0.0196 (4)   0.0162 (4)   0.0155 (3)   0.0032 (3)    0.0024 (3)   0.0062 (3)
  Br2   0.0249 (4)   0.0131 (3)   0.0198 (4)   −0.0001 (3)   0.0110 (3)   −0.0037 (3)
  N1    0.009 (3)    0.008 (3)    0.011 (3)    −0.002 (2)    0.004 (2)    0.000 (2)
  N2    0.014 (3)    0.009 (3)    0.008 (2)    −0.002 (2)    0.003 (2)    0.003 (2)
  N3    0.010 (3)    0.009 (3)    0.011 (3)    0.002 (2)     0.003 (2)    0.004 (2)
  C1    0.018 (4)    0.012 (3)    0.012 (3)    −0.003 (3)    0.003 (3)    −0.006 (3)
  C2    0.013 (3)    0.010 (3)    0.011 (3)    0.003 (3)     −0.003 (3)   0.005 (2)
  C3    0.017 (4)    0.010 (3)    0.018 (3)    −0.002 (3)    −0.006 (3)   −0.002 (3)
  C4    0.013 (4)    0.019 (4)    0.032 (4)    −0.002 (3)    0.005 (3)    0.005 (3)
  C5    0.014 (4)    0.027 (4)    0.025 (4)    0.001 (3)     0.007 (3)    0.009 (3)
  C6    0.014 (4)    0.018 (4)    0.015 (3)    0.003 (3)     0.003 (3)    0.001 (3)
  C7    0.014 (4)    0.016 (3)    0.013 (3)    0.001 (3)     0.009 (3)    −0.004 (3)
  C8    0.019 (4)    0.011 (3)    0.010 (3)    −0.001 (3)    0.003 (3)    0.005 (3)
  C9    0.018 (4)    0.019 (4)    0.016 (3)    0.003 (3)     0.007 (3)    0.005 (3)
  C10   0.011 (3)    0.015 (3)    0.024 (4)    −0.004 (3)    0.002 (3)    0.009 (3)
  C11   0.019 (4)    0.015 (3)    0.020 (4)    −0.001 (3)    −0.002 (3)   0.001 (3)
  C12   0.021 (4)    0.008 (3)    0.016 (3)    0.002 (3)     0.003 (3)    0.007 (3)
  C13   0.010 (3)    0.010 (3)    0.015 (3)    0.002 (3)     0.005 (3)    0.004 (2)
  C14   0.007 (3)    0.008 (3)    0.013 (3)    0.000 (2)     0.001 (2)    0.005 (2)
  ----- ------------ ------------ ------------ ------------- ------------ -------------

Geometric parameters (Å, °) {#tablewrapgeomlong}
===========================

  ---------------------- ------------- ------------------------- ------------
  Cu1---N2               2.015 (6)     C5---C6                   1.375 (11)
  Cu1---N3               2.019 (6)     C5---H5                   0.9500
  Cu1---N1               2.053 (5)     C6---H6                   0.9500
  Cu1---Br2              2.4099 (11)   C7---C8                   1.502 (10)
  Cu1---Br1              2.7045 (11)   C7---H7A                  0.9900
  N1---C7                1.482 (8)     C7---H7B                  0.9900
  N1---C1                1.482 (9)     C8---C9                   1.394 (10)
  N1---C13               1.495 (8)     C9---C10                  1.382 (11)
  N2---C6                1.340 (9)     C9---H9                   0.9500
  N2---C2                1.349 (9)     C10---C11                 1.388 (11)
  N3---C12               1.337 (9)     C10---H10                 0.9500
  N3---C8                1.349 (9)     C11---C12                 1.389 (11)
  C1---C2                1.496 (10)    C11---H11                 0.9500
  C1---H1A               0.9900        C12---H12                 0.9500
  C1---H1B               0.9900        C13---C14                 1.526 (9)
  C2---C3                1.381 (10)    C13---H13A                0.9900
  C3---C4                1.384 (11)    C13---H13B                0.9900
  C3---H3                0.9500        C14---C14^i^              1.536 (12)
  C4---C5                1.395 (12)    C14---H14A                0.9900
  C4---H4                0.9500        C14---H14B                0.9900

  N2---Cu1---N3          161.0 (2)     C6---C5---H5              120.8
  N2---Cu1---N1          81.4 (2)      C4---C5---H5              120.8
  N3---Cu1---N1          81.0 (2)      N2---C6---C5              122.7 (7)
  N2---Cu1---Br2         98.29 (16)    N2---C6---H6              118.7
  N3---Cu1---Br2         97.22 (16)    C5---C6---H6              118.7
  N1---Cu1---Br2         166.96 (16)   N1---C7---C8              109.0 (5)
  N2---Cu1---Br1         90.12 (16)    N1---C7---H7A             109.9
  N3---Cu1---Br1         97.95 (15)    C8---C7---H7A             109.9
  N1---Cu1---Br1         93.22 (16)    N1---C7---H7B             109.9
  Br2---Cu1---Br1        99.82 (4)     C8---C7---H7B             109.9
  C7---N1---C1           112.7 (5)     H7A---C7---H7B            108.3
  C7---N1---C13          108.6 (5)     N3---C8---C9              121.9 (7)
  C1---N1---C13          111.7 (5)     N3---C8---C7              114.7 (6)
  C7---N1---Cu1          103.9 (4)     C9---C8---C7              123.4 (6)
  C1---N1---Cu1          105.4 (4)     C10---C9---C8             118.9 (7)
  C13---N1---Cu1         114.4 (4)     C10---C9---H9             120.6
  C6---N2---C2           119.0 (6)     C8---C9---H9              120.6
  C6---N2---Cu1          128.2 (5)     C9---C10---C11            119.0 (7)
  C2---N2---Cu1          112.7 (4)     C9---C10---H10            120.5
  C12---N3---C8          119.0 (6)     C11---C10---H10           120.5
  C12---N3---Cu1         128.1 (5)     C10---C11---C12           119.2 (7)
  C8---N3---Cu1          112.9 (5)     C10---C11---H11           120.4
  N1---C1---C2           109.8 (5)     C12---C11---H11           120.4
  N1---C1---H1A          109.7         N3---C12---C11            122.0 (7)
  C2---C1---H1A          109.7         N3---C12---H12            119.0
  N1---C1---H1B          109.7         C11---C12---H12           119.0
  C2---C1---H1B          109.7         N1---C13---C14            115.7 (5)
  H1A---C1---H1B         108.2         N1---C13---H13A           108.4
  N2---C2---C3           121.5 (7)     C14---C13---H13A          108.4
  N2---C2---C1           116.0 (6)     N1---C13---H13B           108.4
  C3---C2---C1           122.5 (6)     C14---C13---H13B          108.4
  C2---C3---C4           119.2 (7)     H13A---C13---H13B         107.4
  C2---C3---H3           120.4         C13---C14---C14^i^        108.6 (7)
  C4---C3---H3           120.4         C13---C14---H14A          110.0
  C3---C4---C5           119.2 (7)     C14^i^---C14---H14A       110.0
  C3---C4---H4           120.4         C13---C14---H14B          110.0
  C5---C4---H4           120.4         C14^i^---C14---H14B       110.0
  C6---C5---C4           118.3 (7)     H14A---C14---H14B         108.3

  N2---Cu1---N1---C7     151.6 (4)     Cu1---N2---C2---C3        −176.6 (5)
  N3---Cu1---N1---C7     −35.6 (4)     C6---N2---C2---C1         −177.1 (6)
  Br2---Cu1---N1---C7    −118.9 (7)    Cu1---N2---C2---C1        4.5 (7)
  Br1---Cu1---N1---C7    62.0 (4)      N1---C1---C2---N2         24.0 (8)
  N2---Cu1---N1---C1     32.9 (4)      N1---C1---C2---C3         −154.9 (6)
  N3---Cu1---N1---C1     −154.3 (4)    N2---C2---C3---C4         −1.4 (10)
  Br2---Cu1---N1---C1    122.4 (7)     C1---C2---C3---C4         177.4 (7)
  Br1---Cu1---N1---C1    −56.7 (4)     C2---C3---C4---C5         −0.5 (11)
  N2---Cu1---N1---C13    −90.2 (4)     C3---C4---C5---C6         2.1 (11)
  N3---Cu1---N1---C13    82.6 (4)      C2---N2---C6---C5         −0.2 (10)
  Br2---Cu1---N1---C13   −0.7 (10)     Cu1---N2---C6---C5        178.0 (5)
  Br1---Cu1---N1---C13   −179.8 (4)    C4---C5---C6---N2         −1.7 (11)
  N3---Cu1---N2---C6     137.8 (7)     C1---N1---C7---C8         158.0 (6)
  N1---Cu1---N2---C6     160.1 (6)     C13---N1---C7---C8        −77.8 (7)
  Br2---Cu1---N2---C6    −6.7 (6)      Cu1---N1---C7---C8        44.4 (6)
  Br1---Cu1---N2---C6    −106.7 (6)    C12---N3---C8---C9        −2.4 (10)
  N3---Cu1---N2---C2     −44.0 (9)     Cu1---N3---C8---C9        177.9 (5)
  N1---Cu1---N2---C2     −21.7 (4)     C12---N3---C8---C7        179.3 (6)
  Br2---Cu1---N2---C2    171.5 (4)     Cu1---N3---C8---C7        −0.3 (7)
  Br1---Cu1---N2---C2    71.6 (4)      N1---C7---C8---N3         −30.7 (8)
  N2---Cu1---N3---C12    −136.2 (7)    N1---C7---C8---C9         151.1 (6)
  N1---Cu1---N3---C12    −158.5 (6)    N3---C8---C9---C10        2.5 (10)
  Br2---Cu1---N3---C12   8.4 (6)       C7---C8---C9---C10        −179.4 (7)
  Br1---Cu1---N3---C12   109.4 (5)     C8---C9---C10---C11       −1.1 (10)
  N2---Cu1---N3---C8     43.4 (9)      C9---C10---C11---C12      −0.2 (10)
  N1---Cu1---N3---C8     21.0 (4)      C8---N3---C12---C11       1.1 (10)
  Br2---Cu1---N3---C8    −172.0 (4)    Cu1---N3---C12---C11      −179.4 (5)
  Br1---Cu1---N3---C8    −71.0 (4)     C10---C11---C12---N3      0.2 (10)
  C7---N1---C1---C2      −151.4 (6)    C7---N1---C13---C14       174.3 (6)
  C13---N1---C1---C2     86.1 (7)      C1---N1---C13---C14       −60.8 (7)
  Cu1---N1---C1---C2     −38.8 (6)     Cu1---N1---C13---C14      58.8 (7)
  C6---N2---C2---C3      1.8 (10)      N1---C13---C14---C14^i^   175.1 (6)
  ---------------------- ------------- ------------------------- ------------

Symmetry codes: (i) −*x*+1, −*y*+1, −*z*+1.

###### Selected bond lengths (Å)

  ----------- -------------
  Cu1---N2    2.015 (6)
  Cu1---N3    2.019 (6)
  Cu1---N1    2.053 (5)
  Cu1---Br2   2.4099 (11)
  Cu1---Br1   2.7045 (11)
  ----------- -------------

[^1]: Current address: Harvard Medical School, Children's Hospital Boston, Department of Radiology, 300 Longwood Ave, Enders 4, Boston, MA 02115, USA.


The overall objective of the Animal Models Core (AMC) is to use the expertise of current investigators and existing resources at Washington University to improve the lives of those with intellectual and developmental disabilities by promoting the optimal development and assessment of new and existing animal models. Genetic abnormalities and acquired insults account for most intellectual and developmental disabilities. Animal models are a potent tool for obtaining a better understanding of these conditions and developing novel strategies for treating, preventing, and ultimately curing these conditions. Work at Washington University on mouse models of hypoxia ischemia(5), tuberous sclerosis(6) and lysosomal storage diseases(7-9) demonstrates the power of this approach. However, models are available for only a few of the many conditions associated with developmental disability, such as cerebral palsy and autism. Moreover, although causes are known in many instances, the cause of intellectual and developmental disabilities remains unknown for 20-90% of affected individuals.(10) Genomic, proteomic, and metabolomic approaches will help narrow this gap. Simultaneously, standard biochemical approaches will continue to identify novel causes such as cerebral folate deficiency, which was first described in 2002.(11) Nevertheless, the need for animal models will continue to grow. Until now, individual investigators at Washington University developed animal models in their own laboratories. On their own, they found other investigators with the expertise needed to help them develop and assess their models. Informal discussions with these investigators highlighted fruitful collaborations between specific individuals, but also brought to light the fact that many investigators had not taken full advantage of the vast expertise available at the university. Thus, a key goal of the AMC is to bring together several research methodologies into a cohesive functional unit to facilitate the development and assessment of animal models with relevance to intellectual and developmental disabilities. Through these discussions, we identified three specific areas to benefit the research community and have thus divided the AMC into three subcores: Genetics/Early Development Subcore: This Subcore will assist investigators with the generation of new animal models using genetic and reproductive/early development techniques. It will assist the development of strategies based on prenatal therapies, gene and stem cell therapy. In addition, it will promote a better understanding of the role of genetic modification in disease processes in IDD. Behavior Subcore: This Subcore will provide behavioral assessment of new and current animal models of intellectual and developmental disability. Neuropathology Subcore: This Subcore will provide neuropathologlcal assessment of new and current animal models of intellectual and developmental disability.


In a broadband wireless access system according to the related art, a channel quality indicator (hereinafter, referred to as “CQI”) is transmitted through a fast feedback channel, a bandwidth (BW) request signal is transmitted through a ranging channel, and acknowledgement/negative acknowledgement (hereinafter, referred to as “ACK/NACK”) signals are transmitted through ACK/NACK channels.
In the aforementioned broadband wireless access system according to the related art, in which the CQI and the bandwidth request signal are respectively transmitted through separate channels, if a mobile station (MS) requests a base station (BS) to provide uplink resources, since the ranging channel is contention-based and a plurality of mobile stations can simultaneously use the same code, it is difficult to success the bandwidth request only one time. Also, for request of uplink resources, CDMA code of 144 bits should be transmitted to the base station, and at least two slots (or six slots: in case of transmission of three CDMA codes) should be used. Accordingly, if transmission is performed several times as the bandwidth request fails to be successfully performed only one time, a problem occurs in that a waste of the power and frequency resources may be caused in the mobile station.
Meanwhile, in order to solve the aforementioned problem, a method for transmitting specific BW request information to a corresponding position without transmitting channel status information to a CQI channel (hereinafter, referred to as “CQICH”) has been suggested. However, this method still has a problem in that channel status information is not transmitted during bandwidth request.
Furthermore, if CQI information and ACK/NACK information are respectively transmitted through separate channels in the same manner as a mobile communication system according to the related art, since ACK/NACK information of the mobile station is prior to CQI information, the mobile station should transmit ACK/NACK information only to the base station, or should additionally allocate corresponding CQICH to transmit CQI information and ACK/NACK information. Also, if an ACKCH region is allocated to a region such as a fast feedback channel, a problem occurs in that a waste of radio resources is caused as a fast feedback channel should newly be allocated.
If each of control information is transmitted through a separate control channel as above, a waste of the transmission power and radio resources may be caused in the mobile station. In this respect, a technique of transmitting additional control information to a control channel is required.


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Linsanity Rule could ease all our off season concerns!

Basically they are filling a claim that will allow teams to sign players in Lin's situation while preserving their MLE!

This means Lin could get signed, a player like a Felton is added for half the MLE and Novak is re-signed for the remainder....however we use it will no doubt be debated until it is done, but the point is that this is a huge victory for The Knicks if it goes through

And lets be real....why would Stern and Silver not want this to workout?

Can you imagine... Nash running the show. Melo is our go to guy. Amare steps it up with Nash getting him the ball where he likes it. Chandler also gets some chemistry going there. We have the DPoY and one of the best, young, in your face defenders in Shumpert. On top of all that you could have people like J.R Smith, Novak and Lin coming off the bench? GTFO. That has to be a championship.

I don't think the Knicks would let the cash cow Lin walk, even though they know Nash would benefit the team more. But if they could get both... !

Can you imagine... Nash running the show. Melo is our go to guy. Amare steps it up with Nash getting him the ball where he likes it. Chandler also gets some chemistry going there. We have the DPoY and one of the best, young, in your face defenders in Shumpert. On top of all that you could have people like J.R Smith, Novak and Lin coming off the bench? GTFO. That has to be a championship.

I don't think the Knicks would let the cash cow Lin walk, even though they know Nash would benefit the team more. But if they could get both... !

i would not let LIN walk based on his potential.....Maybe we can have a star for years to coming instead of always chasing everyone else....

We could go for Shannon Brown I think he a FA maybe even Orange Juice Mayonnaise

^^^^ YES!

Yes to Mayo.

Granted, he would have been perfect playing for D'antoni, but look, like we all said during MDA -- a coach worth his salt needs to maximize the talent he has.

If we could get Nash in this scenario, you still absolutely do it, because championship windows are hard to come by, and we'd have a legit 2-3 yr window if we signed both Nash and Lin and Novak and JR.

Lin could definitely play some SG too as well as backing up Nash at point.

If we stay healthy, and assume Nash makes Amare even 75% of what he once was, I think we'd be right up there with OKC and MIA for the next 3years, and our eventual rebuild would be really nice with Lin/Shump/Melo as our ongoing core, + whatever picks we accumulate along the way.

i would not let LIN walk based on his potential.....Maybe we can have a star for years to coming instead of always chasing everyone else....

any sick SG we can get at 5 million ?

Deshawn Stevenson comes to mind. A gritty and strong defensive player with good shooting ability. Plus he comes on the cheap. Got the bi-annual exception from the Nets this season. Can't see him demanding more than 3 mil.

Granted, he would have been perfect playing for D'antoni, but look, like we all said during MDA -- a coach worth his salt needs to maximize the talent he has.

If we could get Nash in this scenario, you still absolutely do it, because championship windows are hard to come by, and we'd have a legit 2-3 yr window if we signed both Nash and Lin and Novak and JR.

Lin could definitely play some SG too as well as backing up Nash at point.

If we stay healthy, and assume Nash makes Amare even 75% of what he once was, I think we'd be right up there with OKC and MIA for the next 3years, and our eventual rebuild would be really nice with Lin/Shump/Melo as our ongoing core, + whatever picks we accumulate along the way.

"- a coach worth his salt needs to maximize the talent he has. "
cant we just get players that are solid and not again rely on potential.....


Q:

Why is having a NATO missile-defense launch system such a big deal for Russia?

After of its activation almost three years ago, from time to time, I keep hearing on the news about Russia making statements about the NATO missile-defense launch system placed in Deveselu (locally known as "Deveselu shield"), namely that it is a threat to Russia (source and source):

"Both the US and NATO have made it clear the system is not designed
  for or capable of undermining Russia's strategic deterrence
  capability," US assistant secretary of state Frank Rose told a news
  conference in Bucharest. "Russia has repeatedly raised concerns that
  the U.S. and NATO defense are directed against Russia and represent a
  threat to its strategic nuclear deterrent. Nothing could be further
  from the truth," he said.
The United States says it is in "full compliance" with the
  Intermediate-Range Nuclear Forces (INF) Treaty, the landmark Cold
  War-era nuclear accord.
The statement from the U.S. mission to NATO on February 8 came a day
  after Russia demanded the United States destroy a missile-defense
  launch system deployed in NATO member Romania in order to return to
  compliance with the INF.

The Romanian Foreign Ministry also had a reaction to the latest Russian statements:

(..) the ballistic missile shield at Deveselu is a strictly defensive
  military structure, explaining that his remarks come in relation to
  the Russian Defence Ministry having asked the US to destroy the Mk-41
  launching system in the composition of the Deveselu shield, on the
  grounds that it would violate the Intermediate-Range Nuclear Forces
  Treaty (INF).

From a layman's perspective it is quite hard to understand why a defense system would be a serious issue for such a large military power.
Question: Why is having a NATO missile-defense launch system such a big deal for Russia?

A:

Putin has repeatedly (personally) stated that his experts advise that defense-capable missiles can be re-purposed (he calls it "reprogram", obviously invoking the idea that the only change which would be necessary would be flushing of firmware of the missiles).  He, on more than one occasion, invoked the possibility that such "reprogramming" can happen without even the host countries, in Europe, noticing a change.
In the same breath, Putin also insists that any missile siloed too close to Russia can have its range increased in the future, as technology advances.  This claim is somewhat supported by historical precedent.  After the end of the Iran-Iraq war, Iran increased the range of the Soviet missiles (which it received from the USSR) to make them capable of striking Israel.  However, the trade off for increasing the missiles' range was a reduction in their precision.
Putin has stated (in no uncertain terms) that the Russian position is that the US policy may change in the future and that any commitments made may be "reconsidered" (a clear euphemism for "reneged") by the US.  And that, as a result, any hardware allowed to be deployed in Europe may be upgraded (and that the US may upgrade it clandestinely).
NOTE
The links to Putin's speeches only make sense if you can get hold of someone who speaks Russian.  Sorry about that.
As is clear from the 1st link, the "translation" is just a voice over restating the news program's narrative.  The actual words uttered by Putin in public tell a somewhat different story.  In the 1st link, he makes the claim that a change of firmware would not be noticed by Romanians.  I don't believe that this particular point was made in the voice-over "translation".
I have heard him make the same claim about Poland when he was voicing his opposition to missile-defense interceptors in Poland, but I do not currently have a link to it.

A:

Russians are worried that the GBIs (ground-based interceptors) can be nuclear-armed, and used for decapitation strike.
Jeffrey Lewis (of the Arms Control Wonk blog) had an article on one angle of this topic in Foreign Policy magazine in 2016, specifically about accusations about nuclear armed interceptors at Deveselu. In it, while dismissing most of this as Russian propaganda aimed at local Romanian population, he also cites his ealrier 2012 article which explains that Russians have a legit (to them, at least) concern:

It is a funny sort of paranoid fantasy, the notion that the United States might place nuclear weapons on missile defense interceptors and use them to decapitate the Russian leadership in Moscow. But I suspect this is the rub. The simplest explanation for Russia’s overwhelming concern with missile defense is that the General Staff fears that Russia is much, much more vulnerable to an attack against the country’s command-and-control infrastructure — what used to be called decapitation — than we realize. Part of this is a fear that missile defense interceptors could be armed as offensive missiles, part of it is that missile defenses could mop up a disorganized Russian retaliation. Most of it, however, is probably sheer terror at the persistent technological advantage held by the United States in light of Russian vulnerabilities.

Russia could be worried that the state of their strategic response is bad enough that high-efficacy missile-defense sites in Europe meaningfully affect their chances of response and therefore alter strategic balance and allow "reasonable" intentions about first strike without sufficient worry about counter-strike capability. That is a general opposition to almost any missile defense.
Obviously, there are objections to that line of thinking (see this RAND study, which also on top of its own conclusions cites Russian experts). But that doesn't necessarily convince top brass and politicians in Russia any more than technical research convinces their counterparts in the West.

A:

There are probably several reasons for the Russian government to be making these claims. Obvious possibilities include:
They're talking to the Russian population, not the rest of the world
The Russian economy is not doing well, so it's worth focussing the population's attention on external threats. This will tend to distract them from discontent over their living conditions, the steady concentration of power and wealth in the government and its immediate allies, and so on.
We don't know how healthy the Russian strategic deterrent is
The government is short of money, but they have a lot of missiles to maintain.
It's a negotiating strategy
If they make a fuss about a missile defence system, they might be able to get some concession in exchange for accepting it.
The Russians don't regard the Iranian threat as credible
The missile defence systems installed in Poland a decade ago were explicitly for defence against Iranian missiles. The Russians didn't regard that threat as credible, mainly because they feel that the Iranian government is somewhat rational and capable of being deterred by US strategic weapons, and by French and UK SLBMs.
So they don't see any threat that that the missile defence system could be used against, apart from Russia.
They suspect the missile defence system can be rapidly strengthened
One claimed reason why the missile defence system "can't be intended for use against Russia" is that the numbers of missiles are too small to make a significant difference. However, rapid production of weaponry has been an American speciality in the past. The present-day procurement system is quite inefficient, but that could be changed.


Court overturns man's conviction for giving ex middle finger

PITTSBURGH – A Pennsylvania appeals court has overturned the disorderly conduct conviction of a Pittsburgh man who was charged because he flashed his middle finger at his ex-wife.

The Pittsburgh Tribune-Review (http://bit.ly/2eiyVXn ) says Monday's Superior Court decision was based on past rulings by the Pennsylvania Supreme Court that the gesture is not obscene — and therefore not illegal — unless it is used in a sexual context.

Thirty-five-year-old Jason Waugaman was acquitted of an endangerment charge for allegedly driving his truck too close to his ex during a November 2014 child custody exchange. But, he was sentenced to 90 days' probation for disorderly conduct.

Senior Judge Eugene Strassburger wrote in Monday's opinion that, "Unless the First Amendment was repealed when I was not looking, giving someone the middle finger should not constitute a crime."


Injuries have kept players off the court for months, even years, and buried the hopes of entire teams. They’ve derailed entire NBA seasons.

For the Warriors of this season, however, injuries may have brought them prosperity.

Without injuries to projected centers Willie Cauley-Stein and Kevon Looney, they might not know what they have in Marquese Chriss, who was signed to a non-guaranteed contract but is playing his way onto the roster.

The Warriors are positioned to gain what the Suns -- who drafted Chriss in 2016 -- lost when they traded him out of Phoenix after two seasons. That certainly is the perspective of Draymond Green, and his impassioned defense of Chriss is mostly on point.

“He’s been in some pretty tough situations,” Green told reporters Wednesday night, after a 126-93 loss to the Lakers at Staples Center. “No one ever blames the situation, though. It’s always the kid. No one ever blames these s---ty franchises. They always want to blame the kid. It’s not always the kid’s fault.

“He’s getting older now, so he’s not a kid anymore. But he came into this league as a kid. But it’s never the organization’s fault. It’s always that guy.”

“So I’m happy he’s got another opportunity to show what he can really do. Because he’s a prime example.”

Green wasn’t quite done. He also saved some ammo for media, indicating reporters are more likely to direct blame on a player than a franchise.

“Because you’re friends with them,” Green said. “You want all the access from them. So, the way you guys will come out and bash players, y’all don’t do that to organizations because it’s all about access and protecting your future. No one really protects these younger guys’ futures. Because it’s all about ‘what can I do for myself.’

“So, no one talks about the organizations. It’s always just the player, the player, the player. Because they can’t do s--t about it but be young. And their name carries no weight, and then (they’ll) be out of the league and onto the next thing.

“No Phoenix writer is going to bash the Phoenix Suns,” Green continued. “But let’s be frank about it. When he was there, the organization was terrible. Everything was going wrong. But he get blamed, like he’s the problem. When he left, ain’t nothing go right. That’s my take on it.”

OK. Again, some of Green’s claims are on target. There are instances of young players being blamed for their failure, while franchises skate.

The Warriors have been skating for a few years now, but it wasn’t always so. They’ve been kicked plenty over the many lean years they put up. Former owner Chris Cohan was such a punching bag that he retreated from media exposure. His right-hand man, former team president Robert Rowell, also took his absorption of bruises from local media.

That’s about where the Suns are now. Since real estate/banking tycoon Robert Sarver purchased the team 15 years ago, they have been in such a freefall that they’ve become a blight on the league.

The Knicks of the Western Conference.

And they have been taken to task -- nationally and locally -- for being a once-proud franchise run aground by cantankerous and penurious ownership.

Green is wrong about that.

Green likely is right about the Suns not knowing what they had in Chriss. Someone in the front office thought enough to draft him No. 8 overall in 2016. But the chaos upstairs -- largely generated by Sarver -- has resulted in a dizzying array of impulsive and regrettable decisions.

If not for the incompetence of Sarver and the Suns, Chriss probably would not be a Warrior, and he certainly wouldn’t have to accept a non-guaranteed contract, as he did 17 days ago.

And if not for injuries to Cauley-Stein and Kevon Looney, the Warriors might not have much of a file on Chriss, either.

[RELATED: Looney to miss preseason; Dubs hope he'll play in opener]

For now, they stand to benefit from having Chriss on the roster. He’s not there yet, but he will be. Any day now.


Prenatal diagnosis and molecular cytogenetic characterization of de novo pure partial trisomy 6p associated with microcephaly, craniosynostosis and abnormal maternal serum biochemistry.
We present prenatal diagnosis and molecular cytogenetic characterization of de novo pure trisomy 6p22.3 → p25.3 encompassing BMP6 in a fetus associated with microcephaly and craniosynostosis on prenatal ultrasound, abnormal maternal serum biochemistry of a low PAPP-A level in the first-trimester combined test, and a karyotype of 46,XX,der(22)t(6;22)(p22.3;p13)dn. The present case demonstrates the usefulness of rapid prenatal identification of the origin of the extra chromosome material on the short arm of an acrocentric chromosome by spectral karyotyping, fluorescence in situ hybridization and array comparative genomic hybridization. We review the phenotypic abnormality of craniosynostosis in previously reported patients with partial trisomy 6p. We discuss the genotype-phenotype correlation of the involved gene of BMP6 in this case.


Als ich noch Schüler an der Venice High School war in Los Angeles, Kalifornien gab mir mein Geographielehrer folgenden Gedanken auf den Weg: "Einige meiner Schüler glauben, dass die Welt des 21. Jahrhunderts viele Konflikte und Kriege haben wir, andere Schüler glauben dagegen, dass die Welt friedlich und kaufmännisch sein wird. Sie treffen dementsprechende Entscheidung über Ihre Karrieren, einige lassen sich vom Militär rekrutieren, wogegen andere die Handelsschiene fahren und betriebswirtschaftliche Berufe ergreifen."

(For our English readers: When I was still a student at Venice High School in Los Angeles, California, my geography teacher gave me the following piece of advice: "Some of my students believe that the world of the 21st century will have many conflicts and wars, while other students believe that the world will be peaceful and mercantile. They are making the corresponding decisions about their careers; some are letting themselves be recruited by the military, but others are going down a business path and taking on economic professions.")

Die Wirklichkeit ist - wie so häufig - eine Mischung aus Frieden und Krieg.

Aber es scheint erfreulicherweise wirklich so zu sein, dass die friedliche Schiene mindestens so auskömmlich geworden ist wie die kriegerische. Das gilt ganz besonders für Deutschland, denn laut einem Bericht der McKinsey & Company ist Deutschland "Flow-Weltmeister".

(English: The reality is - as so often - a mixture of peace and war. But it seems, luckily, to be the case that the peaceful path is at least as sustaining as the militaristic one. This applies especially to Germany which, according to a report by McKinsey & Company, is the "Flowmaster".)


Q:

JavaScript array iteration direction

When processing a very large in-memory array of uniform (same-type) JavaScript objects (each with just a few columns)...
Is there any impact on performance and/or or any other penalty to consider when choosing to iterate through it as row->column versus column->row?
Example
We have 100,000 data rows from a CSV file, each is an object with 10 integer values, and we need to touch every value in it for a certain calculation.
Will it make any difference whether we iterate through it vertically or horizontally? Does the modern V8 care about such things in the slightest?
var data = [...]; // array of many same-type objects;

// horizontal iteration:
for (var p in data[0]) {
    for (var i = 0; i < data.length; i++) {
        var value = data[i][p]; // current value;
        // calculate here from the value;
    }
}

// vertical iteration:
for (var i = 0; i < data.length; i++) {
    for (var p in data[0]) {
        var value = data[i][p]; // current value;
        // calculate here from the value;
    }
}

A:

Only one way to be sure is to run some benchmarks, I made a jsperf: http://jsperf.com/vertical-vs-horizontal-loop The results depends on the engine like expected. Early results from tests I did (Chrome 42 is Edge on Window 10):
|     UserAgent    | horizontal iteration | vertical iteration | vertical iteration with caching | # Tests |
|:----------------:|:--------------------:|:------------------:|:-------------------------------:|:-------:|
| Chrome 42.0.2311 |         1,067        |         287        |               226               |    2    |
|   Firefox 43.0   |         5,621        |         415        |               443               |    2    |
|      IE 11.0     |          976         |         441        |               313               |    2    |
|  Iron 46.0.2450  |         1,557        |         901        |              1,907              |    2    |
(numbers are ops/s, the higher the better)

Interestingly enough, horizontal iteration ranges from twice faster to dozen of times faster (on Firefox). But vertical iteration with caching is the fastest only on Iron 46 (Chromium fork so V8 engine).
Benchmarks with node v5.1.0:

horizontal iteration x 1,140 ops/sec ±1.11% (63 runs sampled)
  vertical iteration x 833 ops/sec ±0.92% (68 runs sampled)
  vertical iteration with caching x 1,678 ops/sec ±1.13% (67 runs sampled)
  Fastest is vertical iteration with caching


1. Field of the Invention
The present invention is based on the fact that phosphorus has a strong affinity for the surface of metal oxides or hydroxides, and relates to a method of preparing an adsorbent for phosphorus adsorption by absorbing and coating expanded vermiculite with aluminum and heating the coated vermiculite at high temperature to produce aluminum oxide on the surface of the expanded vermiculite so that the expanded vermiculite adsorbs phosphorus with high efficiency, and to an adsorption prepared by the method.
2. Description of Related Art
Generally, freshwater lakes, for example, eco-ponds or artificial lakes, in which water does not easily circulate and stagnates, microbial decomposition easily occurs. Particularly, surface layer water in freshwater lakes comes into active air with air, and thus the concentration of oxygen therein is high so that the propagation of plankton is active. However, when this propagation of plankton reaches a limit, the plankton dies and is deposited at the bottom of the water, and for this reason, organic matter in deep water is decomposed to produce nutrient salts such as phosphorus, which spoil the water.
In addition, nutrient salts such as phosphorus are introduced into ponds or lakes from the surroundings to cause eutrophication that causes the propagation of large amounts of green algae, a change in turbidity, offensive odors, and an increase in biochemical oxygen demand (BOD), thereby deteriorating the water quality.
In an attempt to solve the above-described problems, patent document 1 discloses a filter material for water purification, which is made of zeolite and functions to inhibit the occurrence of various foreign materials and adsorb the foreign materials.
Patent document 2 discloses a loess composition for water purification, which is based on loess and is disposed mainly in rivers and waterways for the purpose of naturally purifying running water.
Patent document 3 discloses a porous sintered aggregate for water purification, which is prepared by sintering loess so as to be able to be used as a filter material for water purification and may further contain charcoal so as to be used as a filter material for plant growth and development.
Patent document 4 discloses a water treatment agent based on natural minerals and plants, which is prepared by powdering minerals such as silicate, elvan, loess, kaolin and zeolite, dissolving the powdery materials in hot water to make a colloidal water solution containing natural mineral components and mixing the water solution with a water solution containing a natural sterilizer at a ratio of 1:1.
Particularly, as a technology of basically blocking or reducing the development of green algae by adsorbing and removing phosphorus among materials that cause the propagation of green algae in water, patent document 5 discloses a technology of forming charcoal powder consisting of, particularly, chaff, into charcoal balls capable of adsorbing phosphorus.
However, the above-described prior art technologies have a problem in that the efficiency of adsorption of phosphorus is very low. Thus, in recent years, there has been an attempt to coat expanded vermiculite with iron or glycerol in order to use the expanded vermiculite as an adsorbent for adsorbing phosphorus. However, in this case, the efficiency of adsorption of phosphorus also does not reach a satisfactory level.