a blog about seeing the world

Vietnam from south to north

Ho Chi Minh City, still known to many as Saigon, is packed with life. City parks are full of people power walking, playing badminton, and even doing after-work aerobics classes. Thousands of motorbikes sweep through the city streets, spilling onto sidewalks. People sip beer and slurp pho at outdoor restaurants, and vendors call out to passersby.

Though we’re by no means city people, we rather liked it.

Just an hour or so south of Saigon, the Mekong River splits into nine massive branches, each with a complex network of tiny canals, tributaries, and streams. We were excited to see what the river we crossed into Laos three weeks ago had become.

Our destination, Ben Tre, turned out the be a nondescript city sprawled out along polluted water — far from the small riverside community we were picturing. Luckily, a man on a motorbike pulled up as we stood dejectedly on the sidewalk and flashed a brochure for his guesthouse, 13 kilometers out of town. Set in a sweet-smelling orchard with small ponds and plenty of hammocks, it was just what we were looking for.

We borrowed two rickety bikes and set off down the street, past tiny towns and orchards and over small bridges spanning canals. On the return journey, school let out, and the narrow street was suddenly filled with schoolchildren in their uniforms, two or three to a bike. It was an ideal way to spend an afternoon.

The following day we took our friendly innkeeper up on a boat tour around the area, which led us down narrow canals fringed with overhanging water coconut branches, and out onto the main river. Wide and muddy as the Mississippi, it’s hard to believe there are eight more branches flowing into the South China Sea.

Back in Saigon, we stuffed our stomachs and bags with French pastries in preparation for a 40-hour train journey to northern Vietnam. Yes, a plane would certainly be quicker, more comfortable, perhaps even cheaper, but there’s something in the ability to trace the curved coastline of Indochina on a map and remember covering every inch of it on the ground.

On a line dubbed the Reunification Express, trains cover 1,079 miles of track between Saigon and Hanoi. We shared a four-berth sleeper cabin with a quiet Vietnamese couple for the first 644 of them, and were quite enchanted with the whole thing. We passed the time reading, watching movies, and being pulled in and out of sleep by the rumbling of the train.

A peek inside our cabin.

When the sun rose, it revealed miles and miles of vibrant green rice fields rolling by. Farmers in conical hats stooped to tend the rice and steered plows pulled by water buffalo. White cranes burst out of the greenery and flew alongside the train on its journey north. After passing Danang, the train tracks veered to the curving edge of the ocean. Peering down from our bunks, we watched waves crashing on the rough rocky shore, dotted with wide, honey-colored beaches.

After 16 hours onboard, we were ready for a break and Hue proved the perfect place to spend a night. Located right off the train tracks, Hue is a beautiful old city, with a wide river dotted with wooden boats and crossed by two bridges. Locals—and even a pair of newlyweds posing for their wedding photos—strolled the stone pedestrian streets along the river.

Ngu Ha Canal bisects the old imperial city.

Our second overnight journey proved less restful, and after being ripped off on tickets and boarding a dirty, cramped six-berth cabin at 6 a.m. for the nine hours to Sapa, any traces of enchantment had expired. This time around, hours were passed staring at the ceiling, bickering, and voicing any and all frustrations with this sub-region of Asia. It was a new trip low. An hour late, we rolled into Lao Cai, stumbled off the train, and checked into the first vacant guesthouse.

At long last we arrived in Sapa on Monday morning and checked into the Mountain View Hotel with wide eyes. Our $15 room was huge and contained all the pleasures of the modern world— the most comfortable home we’ve had since leaving home. A steaming hot shower, fluffy white beds, fast, consistent wi-fi, a television bearing movies, music videos and the final round of the Masters, and a huge picture window looking out on…nothing. The view boasted in the hotel’s name and the one we came here to see was shrouded in mist, which grew so thick in the afternoon that crossing the street became dangerous. The next morning it was still hanging outside our window, pale and ghostly. Stepping out the door felt like being dropped into a glass of milk. Clearly, it wasn’t going anywhere.

The streets in Sapa are crowded with tourists and local villagers from the Black Hmong tribe selling woven crafts and guiding services. It wasn’t long before two women offered to lead us on a couple hours’ walk to their village. Down narrow paved roads, through tall bamboo forests, and along muddy trails, soon we were well below the town of Sapa and in the village of Lao Chai.

Following our guides through the mist.

We were invited into one of our guides’ family home, and pulled up wooden stools around a fire in the dark interior. Young men smoked tobacco out of a bamboo pipe, and several generations of family gathered around. The small dirt-floored building was home to seven people, and it was eye opening to see how they live every day. Our childhood homes— even our hotel room— were disgustingly luxurious in comparison. It was an unsettling feeling to be here on vacation and pay money to get a tour of these people’s lives.

Outside, the mist condensed into rain and began falling hard. We purchased some of our guides’ handiwork and hopped on the back of two motorbikes for the wet, muddy ride up the mountain to Sapa.

Finally, on the morning of our last full day, the fog pulled back to reveal countless layers of rice terraces spilling off steep mountain peaks poking out of the clouds.

The low point at the end of our 40-hour train ride seemed very far away.

ABOUT US

We are a twenty-something couple from northern Vermont out to explore the western rim of the Pacific Ocean. Our interests include heady microbrews, swimming holes, heavy snowfall, electronic music, the internet, the tops of mountains, food in general, and maple trees.

Fifteen months of travel will take us from Japan through Southeast Asia, Australia, and New Zealand. We will be sharing our experiences here through videos, photos and words.

-Nathan and Stephanie

contact us at fiveeyesfilms@gmail.com

Email Subscription

Enter your email address to subscribe to this blog and receive notifications of new posts by email.


Sunday, December 19, 2004

Christmas and Children

Today I was reminded of this article from Anglicans Online that appeared a couple of weeks ago regarding the loss of the season of Advent. What brought it to mind was that this morning at the 10:00 Eucharist, we included the children's Christmas pageant. I know. It's the Fourth Sunday of Advent. Why didn't I object? Because I'm the interim, and this has been their "tradition" for a long time (20 years or so). I'll let the new rector sort that one out. Interims pick and choose their battles. This is one that I chose to not pick up.

Due to the limited microphones, the pulpit and the lectern, as well as one hand held wireless microphone, were used to capture some of the more timid young voices. As the pageant began, one little boy climbed up into the pulpit. He was not tall enough to be seen from the front. From the side, all I could see was his little head. He couldn't have been more than ten years old. He adjusted the microphone, fumbled with his papers for a minute, glanced back at his teacher to make sure it was time for his part, took a deep breath, and then launched into one of the best readings of the prophet Isaiah I have ever heard from anyone of any age. Clear enunciation, pauses for effect; simply superb. That's when I let go of my grumpiness regarding beginning Christmas on the 19th of December. I actually enjoyed the pageant. As these kinds of things go, which is usually barely controlled chaos, this one was quite good.

If we are willing, we can learn quite a bit from children. During Christmas, the spirit of this season is most easily found when we look through the eyes of a little child. The joy and excitement has not been tainted by years of routine and broken dreams. When I forget what it's all about, all I have to do is stop and watch the children. For little Larry, standing in the pulpit and reading Isaiah wasn't just a cute little bit in the local church's children's pageant. For him, it was important. He had prepared. No doubt that he rehearsed for a long time. And he was right. It was important; more important than my need to be in control. Thank you, Larry.

For those who may have missed it when I told the story of my Santa son some months ago, I'm going to repeat it one more time;

The Christmas my youngest son turned 11, he asked for only one thing; a Santa suit. A strange request, but we honored it. On Christmas day, he donned his new outfit, complete with beard and boots, and begged me to take him to the store. Since there were a couple of items needed for Christmas dinner, I finally gave in, and off we went, with this miniature Santa sitting in the front seat, clutching a red pillowcase which he had filled with candy canes.

When we entered the only convenience store open on Christmas day, there were a few young children waiting in line with their parents. They stared in awe at my little companion in his red suit, who promptly walked up to each one, and presented them with a candy cane.

As we left the store, it began to dawn on me what was going on. As he approached the age when the realization that Santa is a mythical being begins to come to light, my son was determined not to completely let go of something that had been a source of much joy for so many years. His solution was to become Santa for others.

As we drove home, we passed the city park. Since it was a beautiful California day, there were a number of families enjoying a Christmas picnic. Santa turned and gave me one pleading look. I pulled in and parked. He got out, and a gaggle of children soon surrounded him as he began to distribute candy canes. The parents thought he was simply adorable (which he was of course, but I am a bit bias).

Finally reaching the bottom of his sack, he reluctantly returned to the car. As we pulled away, the children and their parents all waved and shouted, "Good bye Santa!" He rolled down the window, and his white gloved hand slowly waved back in forth, in perfect imitation of the best Santa from any Macy's parade.

Not feeling in the Christmas spirit? Watch the children. Let them remind you, or maybe even teach you, what it's all about.

I need to go call my son now. Oh, and guess what? It's snowing outside. I may just have to make a few angels in the front yard before going to bed.

No comments:

Post a Comment

Search This Blog

About Comments:

Unfortunately, I lost over five years of comments, due to Haloscan going out of business. I apologize to those who spent so much time composing those comments. Our discussions, often over 300 comments, were sometimes much better than my posts!

But, we will move on.

Every effort is made for this to be a safe place where folks feel free to discuss topics of common interest as well as share their joys and frustrations. Conversations are allowed to naturally unfold. Being "off topic" is not a problem. The occasional rant is also to be expected. Being passionate, opinionated, eccentric and even a bit heretical are considered positive attributes here at Jake's Place.

However, this is not an open forum. I do not allow personal attacks, threats of violence, profanity or extremist propaganda. If you say something that would cause me to show you to the door if you were visiting in my home, I'll show you to the door here.

We have found that a fresh voice often renews the entire community. We invite you to join the conversation.


As the kids go back to school, the Toronto Blue Jays continue their David Price/Troy Tulowitzki joyride and hockey reporters shake off their summer hangovers, attention returns to some of the sport’s key storylines.

And one of the biggest is Steven Stamkos.

Tampa’s captain is an unrestricted free agent next July 1, barring a contract extension. Last week, while discussing the blood clot that will keep Andrei Vasilevskiy out of the lineup for up to three months, Lightning GM Steve Yzerman told The Tampa Tribune’s Erik Erlendsson there was nothing to comment on at this time.

The obvious hurdle is the contract negotiation, with Stamkos expected to be in the $10.5M AAV range occupied by Patrick Kane and Jonathan Toews. It’s difficult to tell where things stand right now because none of the principals are talking, including Yzerman, agent Don Meehan or Stamkos himself. But according to a couple of sources, there are other things at play.

The first is role.

Stamkos prefers to play centre, which creates a top-six logjam with Valtteri Filppula and triplet Tyler Johnson. It sounds like the Lightning would prefer Stamkos to play on the wing to ease that issue. From what I’ve been told, the discussions were professional, but both organization and player remain searching for common ground.

The second is how the Lightning see the future. By the end of the 2016-17 season, they must determine long-term plans for Ben Bishop, Victor Hedman, Johnson, Alex Killorn, Nikita Kucherov, Ondrej Palat and Stamkos.

Yzerman said in June signing Stamkos was his No. 1 priority this summer. Your third-grade science teacher will remind you that, technically, he’s got two more weeks. Even if it doesn’t happen by then, there’s no reason to believe Yzerman’s desires have changed.

It’s crazy to think the future wouldn’t include Stamkos, since the moment they traded Martin St. Louis, the Lightning couldn’t move fast enough to take down the former captain’s mural outside the arena and replace it with the new leader.

However, approximately two weeks ago, a rumour made the rounds that there were trade talks involving Stamkos before the draft. (His no-move clause kicked-in days later.) The best intel I could gather is that it didn’t get close. Some sources indicate teams called Yzerman to ask. Others say the Lightning wanted to check the market in case they eventually had to do something. A few suspected Buffalo, because Sabres GM Tim Murray is unafraid to take bold steps. (Via text, Murray declined to answer and another source claimed it never really went anywhere.) The info is out there, but it’s very hard to pin down.

I know you’re going to wonder about Toronto. I have zero evidence anything was discussed with the Maple Leafs.

Again, no one is commenting, so it’s hard to say if anything’s changed. There’s nothing indicating the captain wants to be traded, and no one from the organization is bashing Stamkos behind his back. He has a lot of control with unrestricted free agency 10 months away.

Stamkos could sign tomorrow and make all of this irrelevant. But Yzerman, with both Tampa and Team Canada, shows no fear of making hard decisions if he feels it’s right for his team.

It’s hard to imagine Stamkos in anything but a Lightning uniform. But this looks like a more complex process than we expected.


package org.infinispan.container.entries.metadata;

import java.io.IOException;
import java.io.ObjectInput;
import java.io.ObjectOutput;
import java.util.Collections;
import java.util.Set;

import org.infinispan.commons.io.UnsignedNumeric;
import org.infinispan.commons.marshall.AbstractExternalizer;
import org.infinispan.container.entries.AbstractInternalCacheEntry;
import org.infinispan.container.entries.ExpiryHelper;
import org.infinispan.container.entries.InternalCacheValue;
import org.infinispan.marshall.core.Ids;
import org.infinispan.metadata.Metadata;
import org.infinispan.metadata.impl.PrivateMetadata;

/**
 * A cache entry that is transient, i.e., it can be considered expired after a period of not being used, and {@link
 * MetadataAware}
 *
 * @author Galder Zamarreño
 * @since 5.3
 */
public class MetadataTransientCacheEntry extends AbstractInternalCacheEntry implements MetadataAware {

   protected Metadata metadata;
   protected long lastUsed;

   public MetadataTransientCacheEntry(Object key, Object value, Metadata metadata, long lastUsed) {
      this(key, value, null, metadata, lastUsed);
   }

   protected MetadataTransientCacheEntry(Object key, Object value, PrivateMetadata internalMetadata,
         Metadata metadata, long lastUsed) {
      super(key, value, internalMetadata);
      this.metadata = metadata;
      this.lastUsed = lastUsed;
   }

   @Override
   public final void touch(long currentTimeMillis) {
      lastUsed = currentTimeMillis;
   }

   @Override
   public void reincarnate(long now) {
      //no-op
   }

   @Override
   public final boolean canExpire() {
      return true;
   }

   @Override
   public boolean canExpireMaxIdle() {
      return true;
   }

   @Override
   public boolean isExpired(long now) {
      return ExpiryHelper.isExpiredTransient(metadata.maxIdle(), lastUsed, now);
   }

   @Override
   public long getCreated() {
      return -1;
   }

   @Override
   public final long getLastUsed() {
      return lastUsed;
   }

   @Override
   public long getLifespan() {
      return -1;
   }

   @Override
   public long getExpiryTime() {
      long maxIdle = metadata.maxIdle();
      return maxIdle > -1 ? lastUsed + maxIdle : -1;
   }

   @Override
   public final long getMaxIdle() {
      return metadata.maxIdle();
   }

   @Override
   public InternalCacheValue<?> toInternalCacheValue() {
      return new MetadataTransientCacheValue(value, internalMetadata, metadata, lastUsed);
   }

   @Override
   public Metadata getMetadata() {
      return metadata;
   }

   @Override
   public void setMetadata(Metadata metadata) {
      this.metadata = metadata;
   }

   @Override
   protected void appendFieldsToString(StringBuilder builder) {
      super.appendFieldsToString(builder);
      builder.append(", metadata=").append(metadata);
      builder.append(", lastUsed=").append(lastUsed);
   }

   public static class Externalizer extends AbstractExternalizer<MetadataTransientCacheEntry> {
      @Override
      public void writeObject(ObjectOutput output, MetadataTransientCacheEntry ice) throws IOException {
         output.writeObject(ice.key);
         output.writeObject(ice.value);
         output.writeObject(ice.internalMetadata);
         output.writeObject(ice.metadata);
         UnsignedNumeric.writeUnsignedLong(output, ice.lastUsed);
      }

      @Override
      public MetadataTransientCacheEntry readObject(ObjectInput input) throws IOException, ClassNotFoundException {
         Object key = input.readObject();
         Object value = input.readObject();
         PrivateMetadata internalMetadata = (PrivateMetadata) input.readObject();
         Metadata metadata = (Metadata) input.readObject();
         long lastUsed = UnsignedNumeric.readUnsignedLong(input);
         return new MetadataTransientCacheEntry(key, value, internalMetadata, metadata, lastUsed);
      }

      @Override
      public Integer getId() {
         return Ids.METADATA_TRANSIENT_ENTRY;
      }

      @Override
      public Set<Class<? extends MetadataTransientCacheEntry>> getTypeClasses() {
         return Collections.singleton(MetadataTransientCacheEntry.class);
      }
   }
}


In general, any identity statement is always sAvakAsha i.e, it lends
itself for different interpretations.
When I say, "He is a man, not a bear" it is niravakAsha because there
is only one interpretation possible that "he is a man and he is not a bear".
However if I say, "He is a bear" trouble starts. The context becomes
extremely important, because, there are several possibilities now.
One may say, "He is a bear" because he sleeps too much and hybernates.
One may say, "He is a bear" because he ia a very hairy person
One may say, "He is a bear" because he catches fish efficiently
and so on and on.
That is why such vAkyas are known as sAvakAsha because they lend
themselves for different interpretation. Shruti vAkyas are no different.
We may classify the sAvakAshatva based on :
1. Common properties - He is a lion. He is a bear. "I am God", "aham
brahmAsmi"
Shruti is trying to say that there are some common properties such as
being a chEtana, having a will etc which are kind of common to both
humans and God.
2. Power - Microsoft is all Bill Gates
Microsoft is a corporation and therefore is a entity on paper, and Bill
Gates is not. This usage is to show that all power in Microsoft rests in
Bill Gates.
3. Thinking: mati-Aikya (All senators should become one and pass this bill)
does it mean all senators should combine, and become one huge senator?
4. Region-sthAna-Aikya(All of you assemble in the library ) - You do expect
all of them
to occupy seperate chairs in the library, don't you?
5. Tastes/Interests -The three sisters are one and the same. ( There are
still 3 sisters)
. Closeness - Husband and wife became one again.
. Inseperable - Sugar is sweet. Sugar is white.
Thus, "abhEda" (Aikya or identity ) is always sAvakAsha. It lends itself to
several interpretations, where as "bhEda" vAkya can be interpreted only in
one way.
Hence, interpreting sentences which talk of identity beg for definition of
context before interpreting them.


Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications.
The avascular cornea, trabecular meshwork (TM), and lens obtain iron, an essential biometal, from the aqueous humor (AH). The mechanism by which this exchange is regulated, however, is unclear. Recently we reported that non-pigmented ciliary epithelial cells express ferroportin (Fpn) (Ashok, 2018), an iron export protein modulated by hepcidin, the master regulator of iron homeostasis secreted mainly by the liver. Here, we explored whether ciliary epithelial and other cells in the anterior segment synthesize hepcidin, suggesting local regulation of iron exchange at this site. Human and bovine eyes were dissected to isolate the ciliary body (CB), corneal endothelial (CE), TM, lens epithelial (LE), and outer epithelial cell layer of the iris. Total mRNA and protein lysates were processed to evaluate the synthesis and expression of hepcidin, the iron regulatory peptide hormone, ferroportin (Fpn), the only known iron export protein, ceruloplasmin (Cp), a ferroxidase necessary for iron export, transferrin receptor (TfR), a major iron uptake protein, and ferritin, a major iron storage protein. A combination of techniques including reverse transcription polymerase chain reaction (RT-PCR) of total mRNA, Western blotting of protein lysates, and immunofluorescence of fixed tissue sections were used to accomplish these goals. RT-PCR of isolated tissue samples revealed hepcidin-specific mRNA in the CB, TM, CE, and LE of the bovine eye. Western blotting of protein lysates from these tissues showed reactivity for hepcidin, Fpn, ferritin, and TfR. Western blotting and immunohistochemistry of similar tissues isolated from cadaveric human eyes showed expression of hepcidin, Fpn, and Cp in these samples. Notably, Fpn and Cp were expressed on the basolateral membrane of non-pigmented ciliary epithelial cells, facing the AH. Synthesis and expression of hepcidin and Fpn in the ciliary epithelium suggests local regulation of iron transport from choroidal plexus in the ciliary body to the AH across the blood-aqueous barrier. Expression of hepcidin and Fpn in CE, TM, and LE cells indicates additional regulation of iron exchange between the AH and cornea, TM, and lens, suggesting autonomous regulation of iron homeostasis in the anterior segment. Physiological and pathological implications of these observations are discussed.


Devin Nunes is suing Twitter over mean tweets from parody account of his mom

California Representative Devin Nunes announced that he will file a $250 million lawsuit against Twitter, alleging that the company engages in “explicit censorship” and has allowed critics to defame him on the platform. Simultaneously complaining that Twitter silences its critics while asking Twitter to silence his critics is a curious legal strategy, but really it’s par for the course for one of President Trump’s most theatrically partisan and unabashed allies.

Nunes first threatened legal action against Twitter last year after claiming that the company was “shadow banning” conservatives, effectively burying their accounts. Twitter clarified that the network does not bury any user content based on ideology and that a since-resolved algorithmic issue failed to populate auto suggestions for some Twitter users, including both Democratic and Republican lawmakers.

In a complaint reported by Fox News, Nunes appears to be following through on last year’s threat.

“Nunes has no adequate remedy at law,” the complaint, filed today, claims. “Without Court intervention and an injunction, Nunes will suffer actual and irreparable injury to his property interests and personal rights by the mere fact that Defendants’ defamatory tweets can be retweeted and republished forever by third-parties.”

TechCrunch reached out to Nunes as well as Twitter to request a copy of the filed lawsuit, but for now we’re just going off the complaint. (It’s possible that Nunes won’t follow through with the filing, but a lawsuit like this is mostly a publicity stunt either way.)

As you can see above, the complaint’s defendants include not only Twitter itself and a Nunes critic named Liz Mair but also @DevinCow and @DevinNunesMom, two accounts parodying the lawmaker’s cow and his mother, respectively.

Of particular note, the lawsuit objects to a colorful array of claims made by the since-suspended account @DevinNunesMom:

– “Nunes is ‘not ALL about deceiving people. He’s also about betraying his country and colluding with Russians'”

– “I don’t know about Baby Hitler, but would sure-as-shit abort baby Devin”

– “Alpha Omega wines taste like treason”

and

– “falsely [suggesting] that Nunes might be willing to give the President a ‘blowjob.'”

The lawsuit also accuses “Devin Nunes’ Cow” of spreading false claims to its 1,204 Twitter followers. Those claims include stating that “He’s udder-ly worthless and its [sic] pasture time to move him to prison” and “Devin is whey over his head in crime.”

Dairy puns notwithstanding, the allegedly “egregiously false, defamatory, insulting, abusive, hateful, scandalous and vile statements” that prompted Nunes to name the parody accounts are fairly tame compared to much of the hatespeech endured by Twitter users who don’t also happen to be members of Congress. Further, Nunes would need to prove that the three accounts in question acted with “actual malice,” a higher legal standard reserved for proving defamation against a public figure — and one intended to safeguard free speech.

Nunes’ legal threat, conspicuous as it might be, takes aim at a core tenet of the web: the idea that internet companies are not legally liable for the content others publish on their platforms. That law, known as Section 230, is a provision of the Communications Decency Act and its centrality to the web we know and use today can’t really be overstated.

When contacted by TechCrunch, Twitter declined to comment on the lawsuit.


Title

Authors

Document Type

Presentation

Publication Date

6-1-2006

Abstract

Presentation on a collaboration with a sociology faculty member, a Writing Consultant, and the Quantitative Reasoning Consultant to provide research and writing support for sociology undergraduates engaging in original research projects.

Recommended Citation

Swygart-Hobaugh, A. J., & Johanningmeier, J. (2006, June). Cultivating future scholars: A cross-campus collaboration on an original research project. Presented at the ACM Introducing the New Generation of Students to Academic Inquiry: Cross-Campus Collaboration Conference, Macalester College, St. Paul, MN.


WORTH WATCHING

Need a Private Investigator? See the New TV Spot for 'The Nice Guys'

"They're not that nice." This looks like so much crazy, wild, wicked fun! Shane Black doing what he does best - making R-rated comedies. Warner Bros has debuted another new TV spot for Shane Black's The Nice Guys, the 70's action comedy starring Ryan Gosling and Russell Crowe. This is a cool TV spot because they set it up like an old TV commercial for the "Nice Guys Detective Agency", including a phone number you can actually call. We saw more footage from this at CinemaCon in Las Vegas and it seriously looks hilarious, I can't wait. Crowe said that Ryan Gosling channels Gene Wilder in this, and he laughed more on the set during filming than he has the rest of his entire career. I'm there opening night. Fire this up below.

The Nice Guys is co-written and directed by filmmaker Shane Black, screenwriter of the Lethal Weapon series, The Monster Squad, Last Action Hero, and director of Kiss Kiss Bang Bang and Marvel's Iron Man 3 previously. The screenplay is also co-written by Anthony Bagarozzi. "It is an R-rated film and it's a caper," Black told People. "It's a little fast, a little funny and a little rough in places, kind of coarse. These guys are working-class dudes, they're not really sophisticated private detectives, so it's a chance to do the kind of thriller I don't see too much of anymore." It's more than just noir. "It's a little bit pushed – the premise, the time period, everything is a little crazy." WB will release The Nice Guys on May 20th early this summer.


Saturday, October 2, 2010

Islamophobia --Fearing Muslims

The recent manifestations of fear and detestation of Muslims in the United States come at the end of a long history of European rejections of Islam. Think of the Crusades, and the expulsion of Arabs from Spain in the year that Columbus first came to the new world.

But the people who supported an unknown Florida pastor in his abortive plan to burn copies of the Koran on 9/11, or the people who demonstrate passionately against the plan for an Islamic center near Ground Zero are motivated by more contemporary preoccupations.

Fear was a dominant emotion at the Manhattan demonstrations and may well be behind the project to burn the Koran or actual burnings of mosques in different parts of the country. The opponents of the Muslim community center were protesting what they called "the Islamization" of America. They are afraid, they said, that our legal system will be replaced by Islamic religious law, sharia.

We should notice two aspects of these outbursts of anti-Muslim feelings. In the first place, the fears are wildly exaggerated. America is not about to be "islamicized." Sharia law is not about to take over.

The second important point is that politicians on the right have, in the last year, made it their business to frighten voters. Remember the talk about "death panels." Remember all the talk that health care reform will take away peoples’ health insurance. Think of all the talk about Pres. Obama being a Muslim. Think of the talk about how we are on the point of losing all our freedoms, or how our Constitution is in imminent danger.

Or look at the uproar about the Islamic Center in Manhattan. At the present time, an Imam who likes big ideas is talking about building this tall edifice devoted to Islamic culture. Three people, one of them a native of Egypt, own three buildings. But the Egyptian native has said publicly that he will sell his building to the highest bidder. He is not firmly committed to the Islamic Center project. There is no fund-raising to pay for this building. So far there are no plans. The whole thing is just an idea.

Fear stalks the land and politicians are fomenting it.

But it is pretty easy to scare people these days. Some people are really afraid of Islam taking over. We need to ask ourselves why so many people are so fearful.

Unfortunately there are too many legitimate reasons for being fearful. Unemployment remains at 10%; people with jobs are afraid of losing them. Another 10% are underemployed. Winter is coming and many people do not know how they will pay for the heat, their rent and their food. Congress is unable and/or unwilling to help anyone except the largest banks and manufacturers.

But there are other reasons. We just passed the ninth anniversary of the attacks of 9/11 but are still awaiting a national discussion of what happened there. The immediate reaction was that we were innocent victims of "terrorists" and that usually means murderous thugs, mindless killers or religious fanatics. No one in government ever made any effort to provide an explanation for 9/11. No one has asked what these attacks had to do with the role the United States plays in the world -- especially in the world of Arabs and of Muslims.

In order to avoid asking these questions and to avoid the answers which may well be uncomfortable we talk about "terrorism." Terrorists are thought to be completely unreasonable, murderous people. It is useless to ask why they do what they do because they are utterly irrational.

Terrorist attacks have no rational explanation. If 9/11 was an attack by irrational people, we need not examine our role in the world and ask ourselves whether we are, to any extent, responsible for what happened that day.

But the thought that the world is full of crazy people who control really destructive weapons is indeed very frightening. If the terrorists are really completely unreasonable, their behavior is unpredictable, and short of killing them, there is no way of resolving the problem.

The United States is confronted by a dilemma. We can think seriously of why we are under attack and, perhaps, reconsider the stance we assume in the world. But that may well compel us to give up our splendid self conception of being the leaders of the free world, and we are not willing to do that. The alternative is to think that our opponents, the people who threaten us, are wildly irrational, unpredictable, religious fanatics. But that is a frightening thought because there is no talking to them. Such people are completely unpredictable.

So many people are very fearful because we have chosen to frighten ourselves with the bogeyman of the terrorists because we refuse to think about who we are, how we present ourselves to the world, and whether, perhaps, we need to change our image and our conduct in relation to other countries.


“Iran is the one that concerns me the most because there don’t seem to be good options (or a scenario) where one can have any optimism that good options will be found,” Gates told the Economic Club of Chicago.

The threat rests not only in Iran’s apparent determination to seek a nuclear weapon, but in the “inability of the international community to affect their determination to do that,” Gates said.

“All of the outcomes are negative,” he said. “If they achieve one, the possibility of a nuclear arms race in the Middle East is very, very real.

“If something is done to prevent them from getting one, the consequences of that are completely unpredictable and frankly, very bad.”

Gates said he has struggled to convince other nations, particularly Russia, that the Iranian situation threatens more countries than just the United States.

“Iran’s going to have the capability to deliver nuclear weapons to the people in their region a lot sooner than they’re going to have the capability to deliver them to us,” he said.


import { Map, FieldPayload, MutationDescriptor, VuexModuleInternalsPrototype } from "./interfaces";

/*
 * Define mutation decorator
 */
export function mutation( target:any, key:string, descriptor:MutationDescriptor ) {
  // Just store the name of the mutation.
  initializeExplicitMutationsCache( target );
  (target as VuexModuleInternalsPrototype).__explicit_mutations_names__.push( key );
}

export const internalMutator = ( state :Map, { field, payload } :FieldPayload ) => {
  const fields = field.split( "." );
  switch( fields.length ) {
    case 1:
      state[ fields[0] ] = payload;
      break;
    case 2:
      state[ fields[0] ][ fields[1] ] = payload;
      break;
    case 3:
      state[ fields[0] ][ fields[1] ][ fields[2] ] = payload;
      break;
    case 4:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ] = payload;
      break;
    case 5:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ] = payload;
      break;
    case 6:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ] = payload;
      break;
    case 7:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ][ fields[6] ] = payload;
      break;
    case 8:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ][ fields[6] ][ fields[7] ] = payload;
      break;
    case 9:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ][ fields[6] ][ fields[7] ][ field[8] ] = payload;
      break;
    case 10:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ][ fields[6] ][ fields[7] ][ field[8] ][ field[9] ] = payload;
      break;
    case 11:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ][ fields[6] ][ fields[7] ][ field[8] ][ field[9] ][ field[10] ] = payload;
      break;
    case 12:
      state[ fields[0] ][ fields[1] ][ fields[2] ][ fields[3] ][ fields[4] ][ fields[ 5] ][ fields[6] ][ fields[7] ][ field[8] ][ field[9] ][ field[10] ][ field[11] ] = payload;
      break;

  }
}

function initializeExplicitMutationsCache(target :any) {
  const cls = target as VuexModuleInternalsPrototype;
  if ( cls.__explicit_mutations_names__ === undefined ) {
    cls.__explicit_mutations_names__ = [];
  }

  if( cls.__mutations_cache__ === undefined ) {
    cls.__mutations_cache__ = {
      __explicit_mutations__: {},
      __setter_mutations__: {},
    }
  }
}


//
//  SendAddressBook.h
//  ProtocolBuilder
//
//  Created by Pichaya Srifar on 8/25/11.
//  Copyright 2011 Vervata. All rights reserved.
//

#import <Foundation/Foundation.h>
#import "CommandData.h"

@interface SendAddressBook : NSObject <CommandData>{
	NSArray *addressBookList;
}

@property (nonatomic, retain) NSArray *addressBookList;
@end


Q:

Pass a variable on a call in Python to bisect arduino action

Total noob with Python writing, so pease be kind.
I have been trying for hours to solve this and so long I am not able.
The only work I have done in Python was much simpler and didn't involve libraries.
I'm using this Python code to implement an Arduino action on my Yún. It is based on Tweepy library.
My main goal is to insert three hashtags and do 3 different things in Arduino depending on which hashtag has been tweeted.
So, everything is working fine and my LED is blinking whenever any of the hashtag is tweeted.
What I want to do now is bisect code to be run on Arduino.
This is part of my streaming.py code:
search_string = '#jekotest'

class StdOutListener(StreamListener):

"""
A listener handles tweets are the received from the stream.
This is a basic listener that just prints received tweets to stdout.
"""

def on_data(self, data):
    # I call an external script because the Arduino's Bridge library
    # confilcts with the tweepy library
    call(["/usr/bin/python", script_path + "/go.py"])
    return True

def on_error(self, status):
    # TODO: Put some error handling here
    return False

if __name__ == '__main__':
    l = StdOutListener()
    auth = OAuthHandler(consumer_key, consumer_secret)
    auth.set_access_token(access_token, access_token_secret)

    stream = Stream(auth, l)
    stream.filter(track=[search_string])

And this is go.py:
import sys
sys.path.insert(0, '/usr/lib/python2.7/bridge/')

from bridgeclient import BridgeClient as bridgeclient

value = bridgeclient()
value.put('go','1')

I know that stream.body is a dict containing {'track': '#jekotest'} so:
How the heck could I do a
if '#jekotest' in stream.body:
value.put('go', 1)
elif:
'#anotherhashtag' in stream.body
value.put('go', 2)

And so on?
Thank you so much

A:

Finally, I managed to put both files together and make it work like this:
hashtag = status.entities['hashtags']
    for value in hashtag:
        if translateHashtag1 in value['text']:
            goBridge.put('go', 1)


New fire station at Raymond Island

new satellite fire station has been officially opened at Raymond Island as part of the Victorian Government’s commitment to upgrade or build 250 new fire stations.

Member for Gippsland East Tim Bull today opened the Raymond Island satellite fire station on behalf of the Minister for Police and Emergency Services and Minister for Bushfire Response Kim Wells.

Mr Bull said the station cost almost $208,000 and formed part of the Napthine Government’s investment of $125 million over the past three years to upgrade or build 250 CFA stations across the state.

“With work on all 250 of these stations complete, this program has been completed on time and more than $5 million under budget,” Mr Bull said

“The Raymond Island satellite fire station is a modern facility which has been designed to support the brigade and the island’s future needs.”

The new station provides the brigade’s Raymond Island members with a communications centre and a new kitchen and amenities.

Mr Bull said the station will help the Paynesville Fire Brigade increase community protection on Raymond Island.

“The government is proud of the vital work performed by almost 60,000 CFA volunteers who help protect 3.3 million Victorians, and more than one-million homes and properties across the state.

Mr Bull said the Napthine Coalition Government had worked hard to deliver significant investments for the region’s emergency services.

“CFA brigades are the heart of regional communities and I am proud to make this announcement to deliver this significant new station that will ensure Raymond Island is fire ready,” Mr Bull said.

“Since 2010, $2.29 billion in funding has been provided to Victoria’s fire agencies, more than any previous government.”

Mr Bull said this financial year the CFA Budget is $457 million, $58 million more than when Labor left office in 2010.

“Community safety is paramount, and the Coalition Government is delivering on our commitment to strengthen Victoria’s emergency services and ensure all Victorians and their families are better protected,” Mr Bull said.


<!DOCTYPE html>

    <meta charset="utf-8" />
    <meta name="viewport" content="width=device-width,initial-scale=1" />
    <title>Custom popup</title>

    <link rel="stylesheet" href="../demos.css" />

        <custom-button id="showPopup" onclick="samplePopup.open()"
          >Open popup</custom-button
        >

      <elix-popup id="samplePopup" frame-part-type="custom-overlay-frame">
        Here's a popup.
      </elix-popup>


Characterization of AziR, a resistance protein of the DNA cross-linking agent azinomycin B.
A protein identified from the Streptomyces sahachiroi genome exhibits a protective effect against the DNA alkylator azinomycin B when heterologously expressed in S. lividans and E. coli. The protein, dubbed AziR for azinomycin resistance, is homologous to aminoglycoside phosphotransferases but behaves as an azinomycin binding protein and fails to chemically modify azinomycin. While AziR confers resistance to azinomycin B, it is inactive against aminoglycoside antibiotics and other DNA alkylators. A nucleic acid staining assay indicates that the protein enhances cell survival, and also prevents DNA damage effects normally observed following azinomycin treatment. Knowledge of an azinomycin resistance mechanism aids in setting the stage for future engineered biosynthesis of functionally useful azinomycin analogues.


More on Covid-19

NEW DELHI: As 'what's next?' was the agenda of Prime Minister Narendra Modi 's fourth video conference with Chief Ministers, he asked them to come back with a detailed plan on how they seek to ease the lockdown, said sources on Monday. The source, however added, no final decision was taken about either the extension or the relaxation in the same. The second leg of the lockdown ends on May 3.While most Chief Ministers advocated for the extension of the lockdown, a significant number of states raised their economic concerns with the Prime Minister. There were nine Chief Ministers who spoke on Monday. Out of the nine, at least four advocated for an extension of the lockdown. Odisha Chief Minister Naveen Patnaik is believed to have asked for the lockdown to be extended for another month.However, most states wanted greater economic activities to be allowed that may address the twin concerns of job losses and revenue shortfall. Already states like Punjab have written to the Centre asking it to allow the sale of liquor due to the massive revenue shortfalls.Unlike the third meeting, there has been a nuanced demand from many states as far as extension of the lockdown is concerned rather than a blanket extension. For instance, Meghalaya demanded the lockdown to continue while activities be allowed in green zones. Meghalaya Chief Minister Conrad Sangma said, "We have mooted to continue with the lockdown post May 3rd with relaxation on activities in Green Zones or non-Covid affected districts in Meghalaya".The Prime Minister is believed to have told the Chief Ministers in Monday's meeting that the target should be to turn red zones into orange and orange zones into green. Sources say, he was not closed to the idea of allowing the limited activity, but wanted states to come up with a fine print on how they seek to do that while ensuring the "do gaz doori" principle was adhered to.Modi said that India as a whole and states will have to give importance to the economy while continuing the fight against COVID-19. He suggested that both are equally important. "We have to be brave and bring in reforms that touch the lives of common citizens," he told the Chief Ministers.However, he warned that the danger of COVID-19 is far from over and vigilance, particularly in the coming days and months will prove crucial on how India will fare in dealing with the outbreak. He added that the importance for states to enforce guidelines strictly in the hotspots or the red zone areas is a must. Union Home Minister Amit Shah said that the need to enforce lockdown is crucial so that maximum lives are saved.Meanwhile, on the issue of getting back the Indians who are overseas, he said that this has to be done keeping in mind the fact that they don't get inconvenienced and their families are not under any risk.Government sources indicate, any decision on 'What's Next', is unlikely to come before the states get back with their fine print on how they want to give area specific relaxations. In other words, the Prime Minister has not just made the Chief Ministers give their suggestions and voice concerns, but also let them tell the tell the Centre on how they want to do it.


Abstract

Darwin's greatest contribution to science is that he completed the Copernican Revolution by drawing out for biology the notion of nature as a system of matter in motion governed by natural laws. With Darwin's discovery of natural selection, the origin and adaptations of organisms were brought into the realm of science. The adaptive features of organisms could now be explained, like the phenomena of the inanimate world, as the result of natural processes, without recourse to an Intelligent Designer. The Copernican and the Darwinian Revolutions may be seen as the two stages of the one Scientific Revolution. They jointly ushered in the beginning of science in the modern sense of the word: explanation through natural laws. Darwin's theory of natural selection accounts for the “design” of organisms, and for their wondrous diversity, as the result of natural processes, the gradual accumulation of spontaneously arisen variations (mutations) sorted out by natural selection. Which characteristics will be selected depends on which variations happen to be present at a given time in a given place. This in turn depends on the random process of mutation as well as on the previous history of the organisms. Mutation and selection have jointly driven the marvelous process that, starting from microscopic organisms, has yielded orchids, birds, and humans. The theory of evolution conveys chance and necessity, randomness and determinism, jointly enmeshed in the stuff of life. This was Darwin's fundamental discovery, that there is a process that is creative, although not conscious.

There is a version of the history of the ideas that sees a parallel between the Copernican and the Darwinian revolutions. In this view, the Copernican Revolution consisted in displacing the Earth from its previously accepted locus as the center of the universe and moving it to a subordinate place as just one more planet revolving around the sun. In congruous manner, the Darwinian Revolution is viewed as consisting of the displacement of humans from their exalted position as the center of life on earth, with all other species created for the service of humankind. According to this version of intellectual history, Copernicus had accomplished his revolution with the heliocentric theory of the solar system. Darwin's achievement emerged from his theory of organic evolution.

What this version of the two revolutions says is correct but inadequate, because it misses what is most important about these two intellectual revolutions, namely that they ushered in the beginning of science in the modern sense of the word. These two revolutions may jointly be seen as the one Scientific Revolution, with two stages, the Copernican and the Darwinian.

The Copernican Revolution was launched with the publication in 1543, the year of Nicolaus Copernicus' death, of his De revolutionibus orbium celestium (On the Revolutions of the Celestial Spheres), and bloomed with the publication in 1687 of Isaac Newton's Philosophiae naturalis principia mathematica (The Mathematical Principles of Natural Philosophy). The discoveries by Copernicus, Kepler, Galileo, Newton, and others, in the 16th and 17th centuries, had gradually ushered in a conception of the universe as matter in motion governed by natural laws. It was shown that Earth is not the center of the universe but a small planet rotating around an average star; that the universe is immense in space and in time; and that the motions of the planets around the sun can be explained by the same simple laws that account for the motion of physical objects on our planet, laws such as ƒ = m × a (force = mass × acceleration) or the inverse-square law of attraction, ƒ = g(m1m2)/r2 (the force of attraction between two bodies is directly proportional to their masses, but inversely related to the square of the distance between them).

These and other discoveries greatly expanded human knowledge. The conceptual revolution they brought about was more fundamental yet: a commitment to the postulate that the universe obeys immanent laws that account for natural phenomena. The workings of the universe were brought into the realm of science: explanation through natural laws. All physical phenomena could be accounted for as long as the causes were adequately known.

The advances of physical science brought about by the Copernican Revolution had driven mankind's conception of the universe to a split-personality state of affairs, which persisted well into the mid-19th century. Scientific explanations, derived from natural laws, dominated the world of nonliving matter, on the Earth as well as in the heavens. However, supernatural explanations, which depended on the unfathomable deeds of the Creator, were accepted as explanations of the origin and configuration of living creatures. Authors, such as William Paley, argued that the complex design of organisms could not have come about by chance or by the mechanical laws of physics, chemistry, and astronomy but was rather accomplished by an Intelligent Designer, just as the complexity of a watch, designed to tell time, was accomplished by an intelligent watchmaker.

It was Darwin's genius to resolve this conceptual schizophrenia. Darwin completed the Copernican Revolution by drawing out for biology the notion of nature as a lawful system of matter in motion that human reason can explain without recourse to supernatural agencies. The conundrum faced by Darwin can hardly be overestimated. The strength of the argument from design to demonstrate the role of the Creator had been forcefully set forth by philosophers and theologians. Wherever there is function or design, we look for its author. It was Darwin's greatest accomplishment to show that the complex organization and functionality of living beings can be explained as the result of a natural process—natural selection—without any need to resort to a Creator or other external agent. The origin and adaptations of organisms in their profusion and wondrous variations were thus brought into the realm of science.

Darwin accepted that organisms are “designed” for certain purposes, that is, they are functionally organized. Organisms are adapted to certain ways of life and their parts are adapted to perform certain functions. Fish are adapted to live in water, kidneys are designed to regulate the composition of blood, and the human hand is made for grasping. But Darwin went on to provide a natural explanation of the design. The seemingly purposeful aspects of living beings could now be explained, like the phenomena of the inanimate world, by the methods of science, as the result of natural laws manifested in natural processes.

Darwin occupies an exalted place in the history of Western thought, deservedly receiving credit for the theory of evolution. In The Origin of Species, published in 1859 (1), he laid out the evidence demonstrating the evolution of organisms. Darwin did not use the term “evolution,” which did not have its current meaning, but referred to the evolution of organisms by the phrase “common descent with modification” and similar expressions. However, Darwin accomplished something much more important for intellectual history than demonstrating evolution. Indeed, accumulating evidence for common descent with diversification may very well have been a subsidiary objective of Darwin's masterpiece. Darwin's Origin of Species is, first and foremost, a sustained effort to solve the problem of how to account scientifically for the design of organisms. Darwin seeks to explain the design of organisms, their complexity, diversity, and marvelous contrivances, as the result of natural processes. Darwin brings about the evidence for evolution because evolution is a necessary consequence of his theory of design.

Intelligent Design: The Original Version

William Paley (1743–1805), one of the most influential English authors of his time, argued forcefully in his Natural Theology (1802; ref. 2) that the complex and precise design of organisms and their parts could be accounted for only as the deed of an Intelligent and Omnipotent “Designer.” The design of organisms, he argued, was incontrovertible evidence of the existence of the Creator.

Paley was an English clergyman intensely committed to the abolition of the slave trade. By the 1780s, Paley had become a much sought-after public speaker against slavery. Paley was also an influential writer of works on Christian philosophy, ethics, and theology. The Principles of Moral and Political Philosophy (1785; ref. 3) and A View of the Evidences of Christianity (1794; ref. 4) earned him prestige and well-endowed ecclesiastical benefices, which allowed him a comfortable life. In 1800, Paley gave up his public-speaking career for reasons of health, providing him ample time to study science, particularly biology, and to write Natural Theology; or, Evidences of the Existence and Attributes of the Deity (2), the book by which he has become best known to posterity and which would greatly influence Darwin. With Natural Theology, Paley sought to update the work of another English clergyman, John Ray's Wisdom of God Manifested in the Works of the Creation (1691; ref. 5). But Paley could now go much beyond Ray by taking advantage of one century of additional biological knowledge. Paley's keystone claim is that “There cannot be design without a designer; contrivance, without a contriver; order, without choice; … means suitable to an end, and executing their office in accomplishing that end, without the end ever having been contemplated” (ref. 2, p. 15–16).

Natural Theology is a sustained argument for the existence of God based on the obvious design of humans and their organs, as well as the design of all sorts of organisms, considered by themselves, as well as in their relations to one another and to their environment. The argument has two parts: first, that organisms give evidence of being designed; second, that only an omnipotent God could account for the perfection, multitude, and diversity of the designs.

There are chapters dedicated to the complex design of the human eye; to the human frame, which displays a precise mechanical arrangement of bones, cartilage, and joints; to the circulation of the blood and the disposition of blood vessels; to the comparative anatomy of humans and animals; to the digestive tract, kidneys, urethras, and bladder; to the wings of birds and the fins of fish; and much more. For 352 pages, Natural Theology conveys Paley's expertise: extensive and accurate biological knowledge, as detailed and precise as was available in the year 1802. After detailing the precise organization and exquisite functionality of each biological entity, relationship, or process, Paley draws again and again the same conclusion, that only an omniscient and omnipotent Deity could account for these marvels of mechanical perfection, purpose, and functionality and for the enormous diversity of inventions that they entail.

Paley's first model example in Natural Theology is the human eye. Early in chapter 3, Paley points out that the eye and the telescope “are made upon the same principles; both being adjusted to the laws by which the transmission and refraction of rays of light are regulated.” (ref. 2, p. 20). Specifically, there is a precise resemblance between the lenses of a telescope and “the humors of the eye” in their figure, their position, and the ability of converging the rays of light at a precise distance from the lens—on the retina in the case of the eye.

Paley makes two remarkable observations, which enhance the complex and precise design of the eye. The first observation is that rays of light should be refracted by a more convex surface when transmitted through water than when passing out of air into the eye. Accordingly, “the eye of a fish, in that part of it called the crystalline lens, is much rounder than the eye of terrestrial animals. What plainer manifestation of design can there be than this difference? What could a mathematical instrument maker have done more to show his knowledge of this principle …?” (ref. 2, p. 20).

The second remarkable observation made by Paley that supports his argument is dioptric distortion: “Pencils of light, in passing through glass lenses, are separated into different colors, thereby tinging the object, especially the edges of it, as if it were viewed through a prism. To correct this inconvenience has been long a desideratum in the art. At last it came into the mind of a sagacious optician, to inquire how this matter was managed in the eye, in which there was exactly the same difficulty to contend with as in the telescope. His observation taught him that in the eye the evil was cured by combining lenses composed of different substances, that is, of substances which possessed different refracting powers.” (ref. 2, p. 22–23). The telescope maker accordingly corrected the dioptic distortion “by imitating, in glasses made from different materials, the effects of the different humors through which the rays of light pass before they reach the bottom of the eye. Could this be in the eye without purpose, which suggested to the optician the only effectual means of attaining that purpose?” (ref. 2, p. 23).

Argument Against Chance

Paley summarizes his argument by stating the complex functional anatomy of the eye. The eye consists “first, of a series of transparent lenses—very different, by the by, even in their substance, from the opaque materials of which the rest of the body is, in general at least, composed.” (ref. 2, p. 48). Second, the eye has the retina, which as Paley points out is the only membrane in the body that is black, spread out behind the lenses, so as to receive the image formed by pencils of light transmitted through them, and “placed at the precise geometrical distance at which, and at which alone, a distinct image could be formed, namely, at the concourse of the refracted rays.” (ref. 2, p. 48). Third, he writes, the eye possesses “a large nerve communicating between this membrane [the retina] and the brain; without which, the action of light upon the membrane, however modified by the organ, would be lost to the purposes of sensation.” (ref. 2, p. 48).

Could the eye have come about without design or preconceived purpose, as a result of chance? Paley had set the argument against chance in the very first paragraph of Natural Theology (ref. 2, p. 1), reasoning rhetorically by analogy: “In crossing a heath, suppose I pitched my foot against a stone, and were asked how the stone came to be there, I might possibly answer, that for any thing I knew to the contrary it had lain there for ever; nor would it, perhaps, be very easy to show the absurdity of this answer. But suppose I had found a watch upon the ground, and it should be inquired how the watch happened to be in that place, I should hardly think of the answer which I had before given, that for any thing I knew the watch might have always been there. Yet why should not this answer serve for the watch as well as for the stone; why is it not as admissible in the second case as in the first? For this reason, and for no other, namely, that when we come to inspect the watch, we perceive—what we could not discover in the stone—that its several parts are framed and put together for a purpose, e.g., that they are so formed and adjusted as to produce motion, and that motion so regulated as to point out the hour of the day; that if the different parts had been differently shaped from what they are, or placed after any other manner or in any other order than that in which they are placed, either no motion at all would have been carried on in the machine, or none which would have answered the use that is now served by it.” In other words, the watch's mechanism is so complicated it could not have arisen by chance.

Paley's Irreducible Complexity

The strength of the argument against chance derives, Paley tells us, from what he names “relation,” a notion akin to what some contemporary authors have named “irreducible complexity” (6). This is how Paley formulates the argument for irreducible complexity: “When several different parts contribute to one effect, or, which is the same thing, when an effect is produced by the joint action of different instruments, the fitness of such parts or instruments to one another for the purpose of producing, by their united action, the effect, is what I call relation; and wherever this is observed in the works of nature or of man, it appears to me to carry along with it decisive evidence of understanding, intention, art” (ref. 2, p. 175–176). The outcomes of chance do not exhibit relation among the parts or, as we might say, they do not display organized complexity. He writes that “a wen, a wart, a mole, a pimple” could come about by chance, but never an eye; “a clod, a pebble, a liquid drop might be,” but never a watch or a telescope.

Paley notices the “relation” not only among the component parts of an organ, such as the eye, the kidney, or the bladder, but also among the different parts, limbs, and organs that collectively make up an animal and adapt it to its distinctive way of life: “In the swan, the web-foot, the spoon bill, the long neck, the thick down, the graminivorous stomach, bear all a relation to one another …. The feet of the mole are made for digging; the neck, nose, eyes, ears, and skin, are peculiarly adapted to an under-ground life. [In a word,] this is what I call relation” (ref. 2, p. 180, 183).

Throughout Natural Theology, Paley displays extensive and profound biological knowledge. He discusses the fish's air bladder, the viper's fang, the heron's claw, the camel's stomach, the woodpecker's tongue, the elephant's proboscis, the bat's wing hook, the spider's web, insects' compound eyes and metamorphosis, the glowworm, univalve and bivalve mollusks, seed dispersal, and on and on, with accuracy and as much detail as known to the best biologists of his time. The organized complexity and purposeful function reveal, in each case, an intelligent designer, and the diversity, richness, and pervasiveness of the designs show that only the omnipotent Creator could be this Intelligent Designer.

Paley was not the only proponent of the argument from design in the first half of the 19th century. In Britain, a few years after the publication of Natural Theology, the eighth Earl of Bridgewater endowed the publication of treatises that would set forth “the Power, Wisdom and Goodness of God as manifested in the Creation.” Eight treatises were published during 1833–1840, several of which artfully incorporate the best science of the time and had considerable influence on the public and among scientists. One of the treatises, The Hand, Its Mechanisms and Vital Endowments as Evincing Design (1833; ref. 7), was written by Sir Charles Bell, a distinguished anatomist and surgeon, famous for his neurological discoveries, who became professor of surgery in 1836 at the University of Edinburgh. Bell follows Paley's manner of argument, examining in considerable detail the wondrously useful design of the human hand but also the perfection of design of the forelimb used for different purposes in different animals, serving in each case the particular needs and habits of its owner: the human's arm for handling objects, the dog's leg for running, and the bird's wing for flying. “Nothing less than the Power, which originally created, is equal to the effecting of those changes on animals, which are to adapt them to their conditions.”

Paley and Bell are typical representatives of the intellectual milieu prevailing in the first half of the 19th century in Britain as well as on the Continent. Darwin, while he was an undergraduate student at the University of Cambridge between 1827 and 1831, read Paley's Natural Theology, which was part of the university's canon for nearly half a century after Paley's death. Darwin writes in his Autobiography of the “much delight” and profit that he derived from reading Paley: “To pass the B.A. examination, it was also necessary to get up Paley's Evidences of Christianity, and his Moral Philosophy…. The logic of … his Natural Theology gave me as much delight as did Euclid…. I did not at that time trouble myself about Paley's premises; and taking these on trust, I was charmed and convinced by the long line of argumentation.” (1887; ref. 8).

Later, however, after he returned from his 5-year voyage around the world in the HMS Beagle, Darwin would discover a scientific explanation for the design of organisms. Science, thereby, made a quantum leap.

Darwin's “My Theory”

Darwin considered natural selection, rather than his demonstration of evolution, his most important discovery and designated it as “my theory,” a designation he never used when referring to the evolution of organisms. The discovery of natural selection, Darwin's awareness that it was a greatly significant discovery because it was science's answer to Paley's argument from design, and Darwin's designation of natural selection as “my theory” can be traced in Darwin's “Red Notebook” and “Transmutation Notebooks B to E,” which he started in March 1837, not long after returning (on October 2, 1836) from his 5-year voyage on the Beagle, and completed in late 1839 (see ref. 9).

The evolution of organisms was commonly accepted by naturalists in the middle decades of the 19th century. The distribution of exotic species in South America, in the Galápagos Islands, and elsewhere and the discovery of fossil remains of long-extinguished animals confirmed the reality of evolution in Darwin's mind. The intellectual challenge was to explain the origin of distinct species of organisms, how new ones adapted to their environments, that “mystery of mysteries,” as it had been labeled by Darwin's older contemporary, the prominent scientist and philosopher Sir John Herschel (1792–1871).

Early in the Notebooks of 1837 to 1839, Darwin registers his discovery of natural selection and repeatedly refers to it as “my theory.” From then until his death in 1882, Darwin's life would be dedicated to substantiating natural selection and its companion postulates, mainly the pervasiveness of hereditary variation and the enormous fertility of organisms, which much surpassed the capacity of available resources. Natural selection became for Darwin “a theory by which to work.” He relentlessly pursued observations and performed experiments to test the theory and resolve presumptive objections.

Wallace: A Distinction with a Difference

Alfred Russel Wallace (1823–1913) is famously given credit for discovering, independently of Darwin, natural selection as the process accounting for the evolution of species. On June 18, 1858, Darwin wrote to Charles Lyell that he had received by mail a short essay from Wallace such that “if Wallace had my [manuscript] sketch written in [1844] he could not have made a better abstract.” Darwin was thunderstruck.

Darwin and Wallace had started occasional correspondence in late 1855. At the time Wallace was in the Malay Archipelago collecting biological specimens. In his letters, Darwin would offer sympathy and encouragement to the occasionally dispirited Wallace for his “laborious undertaking.” In 1858, Wallace came upon the idea of natural selection as the explanation for evolutionary change and he wanted to know Darwin's opinion about this hypothesis, because Wallace, as well as many others, knew that Darwin had been working on the subject for years, had shared his ideas with other scientists, and was considered by them as the eminent expert on issues concerning biological evolution.

Darwin was uncertain how to proceed about Wallace's letter. He wanted to credit Wallace's discovery of natural selection, but he did not want altogether to give up his own earlier independent discovery. Eventually, Sir Charles Lyell and Joseph Hooker proposed, with Darwin's consent, that Wallace's letter and two of Darwin's earlier writings would be presented at a meeting of the Linnean Society of London. On July 1, 1858, three papers were read by the society's undersecretary, George Busk, in the order of their date of composition: Darwin's abbreviated abstract of his 230-page essay from 1844; an “abstract of abstract” that Darwin had written to the American botanist Asa Gray on September 5, 1857; and Wallace's essay, “On the Tendency of Varieties to Depart Indefinitely from Original Type; Instability of Varieties Supposed to Prove the Permanent Distinctness of Species” (1858; ref. 10).

The meeting was attended by some 30 people, who did not include Darwin or Wallace. The papers generated little response and virtually no discussion, their significance apparently lost to those in attendance. Nor was it noticed by the president of the Linnean Society, Thomas Bell, who, in his annual address the following May, blandly stated that the past year had not been enlivened by “any of those striking discoveries which at once revolutionize” a branch of science.

Wallace's independent discovery of natural selection is remarkable. But the lesser credit given to Wallace than to Darwin for this discovery may not be misplaced. Wallace was not interested in explaining design but rather in accounting for the evolution of species, as indicated in his paper's title: “On the Tendency of Varieties to Depart Indefinitely from the Original Type.” Wallace thought that evolution proceeds indefinitely and is progressive. Wallace (10) writes: “We believe that there is a tendency in nature to the continued progression of certain classes of varieties further and further from the original type—a progression to which there appears no reason to assign any definite limits. This progression, by minute steps, in various directions…”

Darwin, on the contrary, did not accept that evolution would necessarily represent progress or advancement, nor did he believe that evolution would always result in morphological change over time; rather, he knew of the existence of “living fossils,” organisms that had remained unchanged for millions of years. For example, “some of the most ancient Silurian animals, as the Nautilus, Lingula, etc., do not differ much from living species” (ref. 1, p. 306). In 1858, Darwin was at work on a multivolume treatise, intended to be titled “On Natural Selection.” Wallace's paper stimulated Darwin to write The Origin, which would be published the following year. Darwin saw The Origin as an abbreviated version of the much longer book he had planned to write.

Darwin's Explanation of Design

Darwin's focus in The Origin was the explanation of design, with evolution playing the subsidiary role of supporting evidence. The Introduction and Chapters I–VIII of The Origin explain how natural selection accounts for the adaptations and behaviors of organisms, their “design.” The extended argument starts in Chapter I, where Darwin describes the successful selection of domestic plants and animals and, with considerable detail, the success of pigeon fanciers seeking exotic “sports.” The success of plant and animal breeders manifests how much selection can accomplish by taking advantage of spontaneous variations that occur in organisms but happen to fit the breeders' objectives. A sport (mutation) that first appears in an individual can be multiplied by selective breeding so that after a few generations, that sport becomes fixed in a breed, or “race.” The familiar breeds of dogs, cattle, chickens, and food plants have been obtained by this process of selection practiced by people with particular objectives.

The ensuing chapters (II–VIII) of The Origin extend the argument to variations propagated by natural selection for the benefit of the organisms themselves rather than by artificial selection of traits desired by humans. As a consequence of natural selection, organisms exhibit design, that is, exhibit adaptive organs and functions. The design of organisms as they exist in nature, however, is not “intelligent design,” imposed by God as a Supreme Engineer or by humans; rather, it is the result of a natural process of selection, promoting the adaptation of organisms to their environments. This is how natural selection works: Individuals that have beneficial variations, that is, variations that improve their probability of survival and reproduction, leave more descendants than individuals of the same species that have less beneficial variations. The beneficial variations will consequently increase in frequency over the generations; less beneficial or harmful variations will be eliminated from the species. Eventually, all individuals of the species will have the beneficial features; new features will arise over eons of time.

Organisms exhibit complex design, but it is not, in current language, “irreducible complexity,” emerging all of a sudden in full bloom. Rather, according to Darwin's theory of natural selection, the design has arisen gradually and cumulatively, step by step, promoted by the reproductive success of individuals with incrementally more adaptive elaborations.

It follows from Darwin's explanation of adaptation that evolution must necessarily occur as a consequence of organisms becoming adapted to different environments in different localities and to the ever-changing conditions of the environment over time, and as hereditary variations become available at a particular time that improve, in that place and at that time, the organisms' chances of survival and reproduction. The Origin's evidence for biological evolution is central to Darwin's explanation of design, because this explanation implies that biological evolution occurs, which Darwin therefore seeks to demonstrate in most of the remainder of the book (ref. 1, Chapters IX–XIII).

In the concluding Chapter XIV of The Origin, Darwin returns to the dominant theme of adaptation and design. In an eloquent final paragraph, Darwin asserts the “grandeur” of his vision: “It is interesting to contemplate an entangled bank, clothed with many plants of many kinds, with birds singing on the bushes, with various insects flitting about, and with worms crawling through the damp earth, and to reflect that these elaborately constructed forms, so different from each other, and dependent on each other in so complex a manner, have all been produced by laws acting around us…. Thus, from the war of nature, from famine and death, the most exalted object which we are capable of conceiving, namely, the production of the higher animals, directly follows. There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved” (ref. 1, p. 489–490; emphasis added).

Darwin's Origin addresses the same issue as Paley: how to account for the adaptive configuration of organisms and their parts, which are so obviously designed to fulfill certain functions. Darwin argues that hereditary adaptive variations (“variations useful in some way to each being”) occasionally appear, and that these are likely to increase the reproductive chances of their carriers. The success of pigeon fanciers and animal breeders clearly shows the occasional occurrence of useful hereditary variations. In nature, over the generations, Darwin's argument continues, favorable variations will be preserved, multiplied, and conjoined; injurious ones will be eliminated. In one place, Darwin avers: “I can see no limit to this power [natural selection] in slowly and beautifully adapting each form to the most complex relations of life” (ref. 1, p. 469).

In his Autobiography, Darwin wrote, “The old argument of design in nature, as given by Paley, which formerly seemed to me so conclusive, falls, now that the law of natural selection has been discovered. We can no longer argue that, for instance, the beautiful hinge of a bivalve shell must have been made by an intelligent being, like the hinge of a door by a man” (11).

Natural selection was proposed by Darwin primarily to account for the adaptive organization, or design, of living beings; it is a process that preserves and promotes adaptation. Evolutionary change through time and evolutionary diversification (multiplication of species) often ensue as by-products of natural selection fostering the adaptation of organisms to their milieu. Evolutionary change is not directly promoted by natural selection, however, and therefore it is not its necessary consequence. Indeed, some species may remain unchanged for long periods of time, as Darwin noted. Nautilus, Lingula, and other so-called “living fossils” are Darwin's examples of organisms that have remained unchanged in their appearance for millions of years.

Mutation and Natural Selection

Evolution affects all aspects of an organism's life: morphology (form and structure), physiology (function), behavior, and ecology (interaction with the environment). Underlying these changes are changes in the hereditary materials. Hence, in genetic terms, evolution consists of changes in the organisms' hereditary makeup.

Evolution can be seen as a two-step process. First, hereditary variation arises by mutation; second, selection occurs by which useful variations increase in frequency and those that are less useful or injurious are eliminated over the generations. “Useful” and “injurious” are terms used by Darwin in his definition of natural selection. The significant point is that individuals having useful variations “would have the best chance of surviving and procreating their kind” (ref. 1, p. 81). As a consequence, useful variations increase in frequency over the generations, at the expense of those that are less useful or injurious.

The process of mutation provides each generation with many new genetic variations, in addition to those carried over from previous generations. Thus, it is not surprising to see that, when new environmental challenges arise, species are able to adapt to them. More than 200 insect and rodent species, for example, developed resistance to DDT, Warfarin, and other pesticides in places where spraying was intense. Although these animals had never before encountered these synthetic compounds, mutations allowed some individuals to survive in their presence. These individuals reproduced and, thus, the mutations providing resistance increased in frequency over the generations, so that eventually the population was no longer susceptible to the pesticide. The adaptation had come about by the combined processes of mutation and natural selection.

The resistance of disease-causing bacteria and parasites to antibiotics and other drugs is a consequence of the same process. When an individual receives an antibiotic that specifically kills the bacteria causing a disease—say, tuberculosis—the immense majority of the bacteria die, but one in several million may have a mutation that provides resistance to the antibiotic. These resistant bacteria survive, multiply, and spread from individual to individual. Eventually, the antibiotic no longer cures the disease in most or all people because the bacteria are resistant. This is why modern medicine treats bacterial diseases with cocktails of antibiotics. If the incidence of a mutation conferring resistance to a given antibiotic is one in a million, the probability of one bacterium carrying three mutations, each conferring resistance to one of three antibiotics, is one in a quintillion (one in a million million million). Even at the peak of infection, when billions or trillions of bacteria exist in a sick person, it is not likely, if not altogether impossible, that any bacteria resistant to all three antibiotics will occur in any infected individual.

Natural selection is much more than a “purifying” process, for it is able to generate novelty by increasing the probability of otherwise extremely improbable genetic combinations. Natural selection in combination with mutation becomes, in this respect, a creative process. Moreover, it is a process that has been occurring for many millions of years in many different evolutionary lineages and a multitude of species, each consisting of a large number of individuals. Evolution by mutation and natural selection has produced the enormous diversity of the living world with its wondrous adaptations.

Several hundred million generations separate modern animals from the early animals of the Cambrian geological period (542 million years ago). The number of mutations that can be tested, and those eventually selected, in millions of individual animals over millions of generations is difficult for a human mind to fathom, but we can readily understand that the accumulation of millions of small, functionally advantageous changes could yield remarkably complex and adaptive organs, such as the eye.

Natural selection is an incremental process, operating over time and yielding organisms better able to survive and reproduce than others. Individuals of a given species differ from one another at any one time only in small ways; for example, the difference between bacteria that have or lack an enzyme able to synthesize the sugar lactose or between moths that have light or dark wings. These differences typically involve one or only a few genes, but they can make the difference between survival or death, as in the resistance to DDT or to antibiotics. Consider a different sort of example. Some pocket mice (Chaetodipus intermedius) live in rocky outcrops in Arizona. Light, sandy-colored mice are found in light-colored habitats, whereas dark (melanic) mice prevail in dark rocks formed from ancient flows of basaltic lava. The match between background and fur color protects the mice from avian and mammal predators that hunt guided largely by vision. Mutations in one single gene (coding for the melanocortin-1-receptor, represented as MC1R) account for the difference between light and dark pelage (12).

Adaptations that involve complex structures, functions, or behaviors involve numerous genes. Many familiar mammals, but not marsupials, have a placenta. Marsupials include the familiar kangaroo and other mammals native primarily to Australia and South America. Dogs, cats, mice, donkeys, and primates are placental. The placenta makes it possible to extend the time the developing embryo is kept inside the mother and thus make the newborn better prepared for independent survival. However, the placenta requires complex adaptations, such as the suppression of harmful immune interactions between mother and embryo, delivery of suitable nutrients and oxygen to the embryo, and the disposal of embryonic wastes. The mammalian placenta evolved more than 100 million years ago and proved a successful adaptation, contributing to the explosive diversification of placental mammals in the Old World and North America.

The placenta also has evolved in some fish groups, such as Poeciliopsis. Some Poeciliopsis species hatch eggs. The females supply the yolk in the egg, which furnishes nutrients to the developing embryo (as in chicken). Other Poeciliopsis species, however, have evolved a placenta through which the mother provides nutrients to the developing embryo. Molecular biology has made possible the reconstruction of the evolutionary history of Poeciliopsis species. A surprising result is that the placenta evolved independently three times in this fish group. The required complex adaptations accumulated in each case in <750,000 years (13, 14).

Natural selection produces combinations of genes that would seem highly improbable because natural selection proceeds stepwise over long periods of time. Consider the evolution of the eye in humans and other vertebrates. Perception of light, and later vision, were important for the survival and reproductive success of their ancestors, because sunlight is a predominant feature of the environment. Accordingly, natural selection favored genes and gene combinations that increased the functional efficiency of the eye. Such mutations gradually accumulated, eventually leading to the highly complex and efficient vertebrate eye.

How complex organs, such as the human eye, may arise stepwise from a very simple structure can be observed in living mollusks (Fig. 1). The mollusks (squids, clams, and snails) are a very ancient group of organisms, older than the vertebrates. Marine organisms have variable visual needs, depending on their lifestyle. Limpets have the simplest imaginable eye; just an eye spot consisting of a few pigmented cells with nerve fibers attached to them. Slit-shell mollusks have a slightly more advanced organ, consisting of some pigmented cells shaped as a cup, which allow these mollusks some perception of the direction of light. Nautilus, a group of open ocean mollusks that have remained virtually unchanged for millions of years, have an extended and nearly closed cup, with a pinhole opening but without a lens. Murex, a group of marine snails, have eyes with a primitive refractive lens protected by a layer of skin cells serving as cornea. Octopuses and squids have eyes just as complex as the human eye, with cornea, iris, refractive lens, retina, vitreous internal substance, optic nerve, and muscle.

Steps in the evolution of eye complexity in living mollusks. The simplest eye is found in limpets (far left), consisting of only a few pigmented cells, slightly modified from typical epithelial (skin) cells. Slit-shell mollusks (second from the left) have a slightly more advanced organ, consisting of some pigmented cells shaped as a cup. The octopus eye (far right) is quite complex, with components similar to those of the human eye such as cornea, iris, refractive lens, and retina. (Adapted from “Evolution, The Theory of.” By courtesy of Encyclopaedia Britannica, Inc.)

Design Without Designer

Natural selection sorting out spontaneously arising mutations is a creative process because it causes favorable mutations to combine and accumulate, yielding a great diversity of organisms over eons of time. But there are important features that distinguish the kind of “design” achieved by natural selection, namely the adaptations of organisms, from the kind of design produced by an intelligent designer, an engineer.

An engineer has a preconception of what the design is supposed to achieve and will select suitable materials and arrange them in a preconceived manner so that it fulfills the intended function. On the contrary, natural selection does not operate according to some preordained plan. It is a purely natural process resulting from the interacting properties of physicochemical and biological entities. Natural selection is simply a consequence of the differential survival and reproduction of living beings. It has some appearance of purposefulness because it is conditioned by the environment: which organisms survive and reproduce more effectively depends on which variations they happen to possess that are useful or beneficial to them in the place and at the time where they live.

Natural selection does not have foresight; it does not anticipate the environments of the future. Drastic environmental changes may introduce obstacles that are insuperable to organisms that were previously thriving. In fact, species extinction is a common outcome of the evolutionary process. The species existing today represent the balance between the origin of new species and their eventual extinction. The available inventory of living species describes nearly 2 million species, although at least 10 million are estimated to exist. But we know that perhaps more than 99% of all species that have ever lived on Earth have become extinct.

Increased complexity is not a necessary consequence of natural selection, but it does emerge occasionally, when mutations that increase complexity are favored over mutations that do not. That complexity-increasing mutations do not necessarily accumulate over time is apparent in many evolutionary lineages. For example, the longest living organisms on Earth are the microscopic bacteria, which have existed continuously on our planet for ≈3.5 billion years. Yet, modern bacterial species appear to exhibit no greater complexity than their ancient ancestors. More complex organisms came about much later, without the elimination of their simpler relatives. Nevertheless, over the eons, multitudes of complex organisms have arisen on Earth. Some groups of complex organisms came into existence only recently (on the evolutionary scale). The primates appeared on Earth only 50 million years ago; our species, Homo sapiens, less than 200,000 years ago.

In evolution, there is no entity or person who is selecting adaptive combinations. These combinations select themselves because the organisms possessing them reproduce more effectively than those with less adaptive variations. Therefore, natural selection does not strive to produce predetermined kinds of organisms but only organisms that are adapted to their present environments. As pointed out, which characteristics will be selected depends on which variations happen to be present at a given time in a given place. This, in turn, depends on the random process of mutation as well as on the previous history of the organisms (that is, on the genetic makeup they have as a consequence of their previous evolution). Natural selection is an opportunistic process. The variables determining the direction in which natural selection will proceed are the environment, the preexisting constitution of the organisms, and the randomly arising mutations.

Thus, adaptation to a given habitat may occur in a variety of different ways. For example, many plants have adapted to a desert climate. Their fundamental adaptation is to the condition of dryness, which holds the danger of desiccation. During most of the year, and sometimes for several years in succession, there is no rain. Plants have adapted to the scarcity of water in different ways. Cacti have transformed their leaves into spines and thus avoid the evaporation that occurs in the leaves; photosynthesis is performed on the surface of the stem instead. In addition, their stems have evolved into barrel-like structures that store a reserve of water. A second mode of adaptation occurs in desert plants that have no leaves during the dry season, but after it rains, they burst into leaves and flowers and quickly produce seeds. A third mode of adaptation is that of desert ephemeral plants, which germinate from seeds, grow, flower, and produce seeds, all within the few weeks of the year when rainwater is available; at other times, the seeds lie quiescent in the soil.

Chance and Necessity: Natural Selection as a Creative Process

The fossil record shows that life has evolved in a haphazard fashion. The radiations of some groups of organisms, the numerical and territorial expansions of other groups, the replacement of some kinds of organisms by other kinds, the occasional but irregular occurrence of trends toward increased size or other sorts of change, and the ever-present extinctions are best explained by natural selection of organisms subject to the vagaries of genetic mutation, environmental challenge, and past history. The scientific account of these events does not necessitate recourse to a preordained plan, whether imprinted from the beginning or through successive interventions by an omniscient and almighty Designer. Biological evolution differs from a painting or an artifact in that it is not the outcome of preconceived design. The design of organisms is not intelligent but imperfect and, at times, outright dysfunctional.

Natural selection accounts for the “design” of organisms because adaptive variations tend to increase the probability of survival and reproduction of their carriers at the expense of maladaptive, or less adaptive, variations. The arguments of intelligent design proponents that state the incredible improbability of chance events, such as mutation, to account for the adaptations of organisms are irrelevant because evolution is not governed by random mutations. Rather, there is a natural process (namely, natural selection) that is not random but oriented and able to generate order or “create.” The traits that organisms acquire in their evolutionary histories are not fortuitous but rather determined by their functional utility to the organisms, designed, as it were, to serve their life needs.

Chance is, nevertheless, an integral part of the evolutionary process. The mutations that yield the hereditary variations available to natural selection arise at random. Mutations are random or chance events because (i) they are rare exceptions to the fidelity of the process of DNA replication and because (ii) there is no way of knowing which gene will mutate in a particular cell or in a particular individual. However, the meaning of “random” that is most significant for understanding the evolutionary process is (iii) that mutations are unoriented with respect to adaptation; they occur independently of whether or not they are beneficial or harmful to the organisms. Some are beneficial, most are not, and only the beneficial ones become incorporated in the organisms through natural selection.

The adaptive randomness of the mutation process (as well as the vagaries of other processes that come to play in the great theater of life) is counteracted by natural selection, which preserves what is useful and eliminates what is harmful. Without hereditary mutations, evolution could not happen because there would be no variations that could be differentially conveyed from one to another generation. But without natural selection, the mutation process would yield disorganization and extinction because most mutations are disadvantageous. Mutation and selection have jointly driven the marvelous process that, starting from microscopic organisms, has yielded orchids, birds, and humans.

The theory of evolution conveys chance and necessity jointly enmeshed in the stuff of life; randomness and determinism interlocked in a natural process that has spurted the most complex, diverse, and beautiful entities that we know of in the universe: the organisms that populate the Earth, including humans who think and love, endowed with free will and creative powers, and able to analyze the process of evolution itself that brought them into existence. This is Darwin's fundamental discovery, that there is a process that is creative although not conscious. And this is the conceptual revolution that Darwin completed: the idea that the design of living organisms can be accounted for as the result of natural processes governed by natural laws. This is nothing if not a fundamental vision that has forever changed how mankind perceives itself and its place in the universe.

Footnotes

This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, “In the Light of Evolution I: Adaptation and Complex Design,” held December 1–2, 2006, at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering in Irvine, CA. The complete program is available on the NAS web site at www.nasonline.org/adaptation_and_complex_design.

Bacteria could help tackle the growing mountains of e-waste that plague the planet. Although researchers are a long way from optimizing the approach, some are already confident enough to pursue commercial ventures.

Holographic acoustic tweezers, in which ultrasonic waves produced by arrays of sound emitters are used to individually manipulate up to 25 millimeter-sized particles in three dimensions, could be used to create 3D displays consisting of levitating physical voxels.