In study 3 , the decrease in the mean [ standard deviation ] testosterone concentration from baseline to endpoint for male patients receiving tapentadol ER ( 100 mg , -1.9 [ 0.71 ] nmol/L ; 200 mg , -2.1 [ 0.93 ] nmol/L ) was numerically smaller compared to oxycodone CR ( 20 mg , -2.7 [ 0.93 ] nmol/L ) , but higher compared to placebo ( -0.3 [ 1.62 ] nmol/L ) .