The proportion of patients achieving an overall response did not differ between treatment groups ( 235 [ 607 % , 95 % CI 557-656 ] for panobinostat vs 208 [ 546 % , 494-597 ] for placebo ; p = 009 ) ; however , the proportion of patients with a complete or near complete response was significantly higher in the panobinostat group than in the placebo group ( 107 [ 276 % , 95 % CI 232-324 ] vs 60 [ 157 % , 122-198 ] ; p = 000006 ) .