Relative changes in BV between baseline and week 5 ranged from -64 % to +68 % ( median , -16 % ; 25th percentile , -41 % ; 75th percentile , +2 % ) and were significantly associated with OS using quartiles as cutoffs ( 5.2 months vs not reached , P = 0.038 ) and PFS using the median as cutoff ( 5.3 months vs not reached , P = 0.009 ) , with larger reductions associated with longer survival .