The level of inflammation and oxidative stress was markedly reduced in the SDAT patients treated with the test formulation when compared to the donepezil-treated group indicating a likely mechanism of action of the test formulation ( homocysteine 30.22 3.87 vs 44.73 7.11 nmol/L , P < 0.0001 ; C-reactive protein [ CRP ] 4.751 1.149 vs 5.887 1.049 mg/L , P < 0.0001 ; tumour necrosis factor alpha [ TNF - ] 1139.45 198.87 vs 1598.77 298.52 pg/ml , P < 0.0001 ; superoxide dismutase [ SOD ] 1145.92 228.75 vs 1296 225.72 U/g Hb , P = 0.0013 ; glutathione peroxidase [ GPx ] 20.78 3.14 vs 25.99 4.11 U/g Hb , P < 0.0001 ; glutathione [ GSH ] 9.358 2.139 vs 6.831 1.139 U/g Hb , P < 0.0001 ; thiobarbituric acid reactive substances [ TBARS ] 131.62 29.68 vs 176.40 68.11 nmol/g Hb , P < 0.0001 ) .