PCOS women were treated with pioglitazone 30 mg/day and at the beginning and after 6 months of treatment were evaluated : menstrual cycle trend , hirsutism and acne , total cholesterolemia and HDL , triglyceridemia , fibrinogenemia , C-reactive protein , oral glucose tolerance test , glycated hemoglobin , FSH , LH , 17OH-progesterone , 17-estradiol , free and total testosterone , SHBG , DHEA-S , 4-androstenedione and adiponectin .