However , CaD supplementation had differential effects ( P interaction = 0.005 ) in subgroups stratified by baseline risk status of HF defined by the presence ( high risk = 17 449 ) or absence ( low risk = 18 534 ) of pre-existing HF precursors including coronary heart diseases , diabetes mellitus , or hypertension : 37 % ( hazard ratio , 0.63 [ 95 % confidence interval , 0.46-0 .87 ] ) lower risk of HF in the low-risk versus hazard ratio , 1.06 ; P = 0.51 , in the high-risk subgroups .