Of the IL-10-producing Bregs , CD19 ( + ) / CD24 ( high ) / CD38 ( high ) / CD5 ( + ) , CD19 ( + ) / CD24 ( high ) / CD38 ( high ) / CD10 ( + ) , CD19 ( + ) / CD24 ( high ) / CD38 ( high ) / CD20 ( + ) , and CD19 ( + ) / CD24 ( high ) / CD38 ( high ) / CD27 ( - ) had significant higher frequency in patients under belatacept treatment when compared with those under cyclosporine .