hs-TnI was also significantly associated with cardiac death ; annual rates ranged from 0.40 % to 4.24 % , hazard ratio 4.52 ( 3.05-6 .70 ) , P < 0.0001 , in the corresponding groups , and for major bleeding hazard ratio 1.44 ( 1.11-1 .86 ) , P = 0.0250 .