For clinicopathological variables , noncurrent smokers ( OR = 7.98 ; P = 0.001 ) , patients positive to anti-cyclic citrullinated peptide ( OR = 3.53 ; P = 0.004 ) and antinuclear antibodies ( OR = 2.28 ; P = 0.045 ) , with higher health assessment questionnaire score ( OR = 2.42 ; P = 0.007 ) , and nonsteroidal anti-inflammatory drug users ( OR = 2.77 ; P = 0.018 ) were also associated with nonresponse .