Training study : 3-nitrotyrosine ( 3-NT ) decreased ( 2.181.78 to 1.100.93 M ) in the exercise group only , alongside increases in aerobic fitness ( 24.454.98 to 27.104.51 ml/kg/min ( -1 ) ) and reductions in disease activity score ( DAS : 3.471.17 to 2.880.76 ) .