In unadjusted models , group 1 had the lowest rates of the primary outcome ( 9.36 % vs. 12.71 % vs. 21.32 % ; p < 0.0001 ) , all-cause mortality ( 7.92 % vs. 10.07 % vs. 16.81 % ; p < 0.0001 ) , cardiovascular mortality ( 3.26 % vs. 4.58 % vs. 7.80 % ; p < 0.0001 ) , MI ( 1.07 % vs. 1.03 % vs. 2.91 % ; p < 0.0001 ) , total stroke ( 1.19 % vs. 2.63 % vs. 3.85 % ; p < 0.0001 ) , and nonfatal stroke ( 0.86 % vs 1.89 % vs 2.86 % ; p < 0.0001 ) compared with groups 2 and 3 , respectively .