From a random sample achieving an HIV type 1 RNA load of < 50 copies/mL by week 48 , changes over 24 and 48 weeks in levels of biomarkers of monocyte activation ( soluble CD14 [ sCD14 ] and soluble CD163 [ sCD163 ] ) , systemic inflammation ( soluble tumor necrosis factor receptor I [ sTNF-RI ] , interleukin 6 [ IL-6 ] , and high-sensitivity C-reactive protein [ hsCRP ] ) , and vascular inflammation ( lipoprotein-associated phospholipase A2 [ Lp-PLA2 ] ) were compared .