A total of 106 eligible patients with locally advanced , unresectable or metastatic PDAC without previous system therapy were randomised to receive GEM at a dosage of 1.000 mg/m ( 2 ) d1 , 8 , 15 q28 versus a combination of SUNGEM at a dosage of GEM 1.000 mg/m ( 2 ) d1 +8 and sunitinib 50mg p.o. d1-14 , q21d .