MP reduced systemic inflammatory response syndrome from 92 % to 27 % ( P < 0.0001 ) ( number needed to treat = 1.5 ) , maximal plasma interleukin 6 from 186 pg/mL [ interquartile range ( IQR ) = 113-261 pg/mL ] to 20 pg/mL ( IQR = 11-28 pg/mL ) ( P < 0.001 ) and fulfillment of discharge criteria was shorter [ 2 days ( IQR = 2-4 days ) vs 3 days ( IQR = 3-4 days ) ] ( P < 0.001 ) .