On days 1 , 2 , 7 , 14 , 28 , 56 and 84 , the percentage reduction from baseline for owner-assessed pruritus changed from 25.6 to 61.0 % in the oclacitinib group compared with 6.5 to 61.5 % in the ciclosporin group ; differences were significant at all time points up to day 28 .