Compared with a PP range of 40-49 mmHg , PP < 40 was associated with significantly lowered risk of worsening ACR ( 0.36 [ 0.15-0 .87 ] ; P = 0.022 ) and PP 60 with significantly increased risk ( 2.38 [ 1.58-3 .59 ] ; P < 0.0001 ) .