40 patients were randomized to a single subcutaneous ( SC ) injections of 12.5 mg ( n = 10 ) , 25 mg ( n = 10 ) , and 50 mg ( n = 10 ) of rhTNFR-Fc , and six SC injection of rhTNFR - Fc at 25 mg once in 3 days ( n = 10 ) respectively .