The depletion of irisin significantly correlated with changes in some atherogenic-related variables : total cholesterol ( B = 0.106 , P = 0.018 ) , total cholesterol/high-density lipoprotein cholesterol ratio ( B = 0.002 , P = 0.036 ) , low-density lipoprotein cholesterol ( B = 0.085 , P = 0.037 ) and apolipoprotein B ( B = 0.052 , P = 0.002 ) , independently of changes in body weight .