In the whole group ( ie , independently of fat type ) , body weight increased ( +2.2 % , P < 0.001 ) together with increased plasma proinsulin ( +21 % , P = 0.007 ) , insulin ( +17 % , P = 0.003 ) , proprotein convertase subtilisin/kexin type 9 , ( +9 % , P = 0.008 ) fibroblast growth factor-21 ( +31 % , P = 0.04 ) , endothelial markers vascular cell adhesion molecule-1 , intercellular adhesion molecule-1 , and E-selectin ( +9 , +5 , and +10 % , respectively , P < 0.01 for all ) , whereas nonesterified fatty acids decreased ( -28 % , P = 0.001 ) .