Patients with elevated YKL-40 had shorter PFS than patients with normal YKL-40 ( 7.5 vs. 8.2 months ; hazard ratio ( HR ) = 1.27 95 % confidence interval ( CI ) 1.05-1 .53 P = 0.013 ) and shorter OS ( 16.8 vs. 23.9 months ; HR = 1.33 , 1.04-1 .69 , P = 0.024 ) .