The difference in edema , crusting , and mucopurulence at 1 and 2 weeks was not statistically significant ; however , at 6 and 12 weeks , the HA hydrogel showed statistically significant reduction in both overall endoscopic grade ( p < 0.05 ) , as well as synechiae formation ( p < 0.05 ) , with a trend toward superiority in remucosalization ( p = 0.08 ) .