The serum BUN level increased in the high-dose group ( to 54.4 15.0 mmol/L ) , which was statistically different from that in the low-dose group ( vs .57.7 17.3 mmol/L , t = 5.166 , P = 0.022 ) ; the same trend was seen for the serum Cr value ( 397.8 127.4 mumol/L vs. 480.3 179.8 mumol/L , t = 5.638 , P = 0.047 ) .