The 24-h glucose infusion rate area under the curve ( AUC0-24h ) was similar in the evening and morning studies ( 1,058 571 and 995 691 mg/kg 24 h , P = 0.503 ) , but the first 12 h ( AUC0-12h ) was lower with evening versus morning glargine ( 357 244 vs. 593 374 mg/kg 12 h , P = 0.004 ) , whereas the opposite occurred for the second 12 h ( AUC12-24h 700 396 vs. 403 343 mg/kg 24 h , P = 0.002 ) .