However , patients with more frequent wine consumption had a significantly better perception of health status ( Kansas City Cardiomyopathy Questionnaire score , adjusted P < 0.0001 ) , less frequent symptoms of depression ( Geriatric Depression Scale , adjusted P = 0.01 ) , and lower plasma levels of biomarkers of vascular inflammation ( osteoprotegerin and C-terminal proendothelin-1 , adjusted P < 0.0001 , and pentraxin-3 , P = 0.01 ) after adjusting for possible confounders .