RPL554 ( 0018 mg/kg ) did not significantly reduce the percentage of neutrophils in sputum ( 803 % in the RPL554 group vs 842 % in the placebo group ; difference -39 % , 95 % CI -94 to 16 , p = 015 ) , since RPL554 significantly reduced neutrophils ( p = 0002 ) and total cells ( p = 0002 ) to a similar degree .