In study 2 , there were no or minimal changes in testosterone in the therapeutic dose range with tapentadol IR ( 75-100 mg ) , and there was a modest decrease that appeared to level off in the supratherapeutic range ( 125-175 mg ) ; mean testosterone and LH concentrations with all doses remained within normal ranges ( testosterone , 4.56-28 .2 nmol/L ; LH , 2.9-4 .6 U/L ) .