The 5-year composite event rate was significantly lower in patients who achieved the LDL target during the 6-month trial than in those who did not ( 8.8 % vs 17.3 % ; adjusted hazard ratio [ aHR ] , 0.52 ; 95 % confidence interval [ CI ] , 0.27-0 .99 ) , even accounting for statin use ( adjusted P = 0.038 ) .