Although both the certainty ( relative risk [ RR ] 256 , 95 % CI 233-279 ; p < 00001 ) and frequency of coronary heart disease increased ( 109 , 102-117 ; p = 00172 ) , the certainty increased ( 179 , 162-196 ; p < 00001 ) and frequency seemed to decrease ( 093 , 085-102 ; p = 01289 ) for the diagnosis of angina due to coronary heart disease .