The beneficial effect of combination therapy was more pronounced in patients with baseline viral load 800,000 IU/mL than those with baseline viral load < 800,000 IU/mL ( RR : 3.08 [ 95 % CI 1.80 to 5.29 ] vs. RR : 1.11 [ 95 % CI 0.83 to 1.45 ] ; interaction p = 0.001 ) .