Similarly , low-dose nesiritide had no significant effect on 72-hour cumulative urine volume ( nesiritide , 8574 mL ; 95 % CI , 8014-9134 vs placebo , 8296 mL ; 95 % CI , 7762-8830 ; difference , 279 mL ; 95 % CI , -618 to 1176 mL ; P = .49 ) or on the change in cystatin C level ( nesiritide , 0.07 mg/L ; 95 % CI , 0.01-0 .13 vs placebo , 0.11 mg/L ; 95 % CI , 0.06-0 .16 ; difference , -0.04 ; 95 % CI , -0.13 to 0.05 ; P = .36 ) .