Investigator-assessed , qualitative , drug-related differences in grade 2 ( 1.6 % versus 10.6 % ) and grade 3 ( 0.0 % versus 4.1 % ) sensory neuropathy and grade 3/4 fatigue ( 10.9 % versus 5.0 % , p = 0.0012 ) were observed between the pemetrexed and paclitaxel arms .