Study population consisted of 94 patients randomized into two groups : 61 patients ( 53 + / - 8 yrs , training group ) were assigned to a structured exercise training intervention ( 3 times/week for the first 3 months , and once / week for the following 9 months ) ; whereas 33 patients ( 52 + / - 7 yrs , control group ) followed only the general indications to adhere to the life-style intervention suggestions of the DIANA protocol .