The mean CPS values before treatment and those for early , delayed and long-term response were 8.72.9 and 8.13.1 ( p = 0.21 ) ; 4.53.2 and 5.03.4 ( p = 0.51 ) ; 3.93.6 and 2.82.8 ( p = 0.19 ) and 1.52.3 and 2.43.5 ( p = 0.27 ) , respectively .