Regimens were : study 1 : OC ( levonorgestrel ( 150 g ) + ethinyl estradiol ( 30 g ) ) / day ( day 1 ) , canagliflozin 200 mg/day ( days 4 - 8 ) , and canagliflozin with OC ( day 9 ) ; study 2 : canagliflozin 300 mg/day ( days 1 - 12 ) with warfarin 30 mg/day ( day 6 ) in period 1 , and only warfarin 30 mg/day ( day 1 ) in period 2 , or vice versa ; study 3 : digoxin alone ( 0.5 mg/day ( day 1 ) + 0.25 mg/day ( days 2 - 7 ) ) in period 1 , and with canagliflozin 300 mg/day ( days 1 - 7 ) in period 2 , or vice versa .