When using the phenotype of SBP > 160mmHg , the most significant association in SV2C ( rs6453204 ) approached and met genome-wide significance in the binary model ( P = 6.0 10 ( -8 ) ; OR = 3.3 ) and in the cumulative dose model ( P = 4.7 10 ( -8 ) ; HR = 2.2 ) , respectively .