Repeated measure MANOVA found that the patients in the intervention group had significant improvement in their self-efficacy ( F = 7.26 , p = 0.003 ) and a reduction of symptom severity ( F = 5.30 , p = 0.01 ) , symptom interference ( F = 4.06 , p = 0.025 ) , anxiety ( F = 6.04 , p = 0.006 ) and depression ( F = 6.96 , p = 0.003 ) at three and six months , compared with the control group .