DI was randomized as follows : standard risk ( SR ) , two 4-week intensive elements ( protocol III ) versus one 7-week protocol II ; intermediate risk ( IR ) , protocol III 3 versus protocol II 1 ; high risk ( HR ) , protocol III 3 versus either protocol II 2 ( Associazione Italiana Ematologia Oncologia Pediatrica [ AIEOP ] option ) , or 3 HR blocks plus single protocol II ( Berlin-Frankfurt-Mnster [ BFM ] option ) .