The nominal change in the total atheroma volume ( adjusted means ) was -2.71 , -3.13 , -1.50 , and -3.05 mm ( 3 ) with placebo , CER-001 3 mg/kg , 6 mg/kg , and 12 mg/kg , respectively ( primary analysis of 12 mg/kg vs. placebo : P = 0.81 ) .