The overall systemic exposure ( geometric least squares mean ; 95 % CI ) was > 21 % lower for submicron indomethacin 40 mg ( 6007.71 ngh/mL ; 5585.73-6461 .58 ) compared with indomethacin 50 mg ( 7646.23 ngh/ml ; 7110.44-8222 .40 ) under fasting conditions .