Patients with specific biological ( body mass index 30 kg/m , elevated plasma levels of high-sensitivity C-reactive protein or 4-hydroxy-2-nonenal , low S-adenosylmethionine/S-adenosylhomocysteine ratio ) and genetic markers at baseline had significantly ( P .05 ) greater pooled mean change from baseline on the HDRS-28 with L-methylfolate versus placebo .