The elevation in circulating NEFA increased expression of TLR3 , TLR4 and TLR5 , and several MAPK ( MAPK8 , MAP4K4 , MAP2K3 ) and inhibitor of B kinase-NFB ( CHUK [ IKKA ] , c-REL [ REL ] and p65 [ RELA , NFKB3 , p65 ] ) signalling genes ( p < 0.05 ) .