In the subgroup of patients who received all six doses of study drug ( n = 57 ) , the serum ferritin concentration increased significantly for the iron as compared with placebo group on both day 7 ( 808.0 ng/mL vs 457.0 ng/mL , respectively , p < 0.01 ) and day 14 ( 1,046.0 ng/mL vs 551.5 ng/mL , respectively , p < 0.01 ) .