Differences in proportions for grouped data ( outcome 0 and outcome > 0 ) for the total of all visits were Holgers ' Index : 0.13 ( p = 0.0004 ; 95 % confidence interval [ 95 % CI ] , 0.058-0 .21 ) ; sensibility loss : 0.50 ( p = 2.2 10 ; 95 % CI , 0.42-0 .58 ) ; pain : 0.096 ( p = 0.006 ; 95 % CI , 0.026-0 .17 ) .