A total of 612 subjects were randomized in a 2:1 ratio to ( 1 ) MP29-02 , one spray per nostril twice daily ( total daily doses of azelastine hydrochloride and FP were 548 mcg and 200 mcg , respectively ) ; or ( 2 ) FP , 2 sprays per nostril once daily ( total daily dose 200 mcg ) .