After 8 weeks of HCQ , the mean SD ISI increase was 0.4 2.9 compared with a small increase during placebo of 0.14 3.1 ( adjusted P = 0.785 ) , and the mean SD HOMA-IR decrease was 0.3 1.5 during HCQ versus a decrease of 0.42 1.4 during placebo ( adjusted P = 0.308 ) .