Change in Q-LES-Q total score was highly correlated with change in HAM-D17 score at week 12 , LOCF ( P < 0.0001 ) , and improvement in HAM-D17 total score at week 2 predicted change in Q-LES-Q total score at week 12 for the desvenlafaxine group ( F = 24.89 ; P < 0.0001 ) but not placebo .