Gastro-oesophageal reflux disease ( Los Angeles grades A-D ) patients were randomised to 4weeks of treatment with pantoprazole-Mg ( n = 290 ) or esomeprazole ( n = 288 ) , both 40mg once daily , in this multicentre ( 14 Brazilian sites in 9 cities ) , double-blind study , with an additional 4weeks ' treatment in nonresponding patients .