In a double-blind , crossover trial , subjects with asthma who had BHR to inhaled mannitol ( n = 23 ; 14 men ; mean age , 28 years ; one-half taking regular inhaled corticosteroids ) were randomized to omega-3 supplements ( 4.0 g/d eicosapentaenoic acid and 2.0 g/d docosahexaenoic acid ) or matching placebo for 3 weeks separated by a 3-week washout .