At 28 days , there was no significant between-group difference in mortality , with deaths reported in 142 of 388 patients in the high-target group ( 36.6 % ) and 132 of 388 patients in the low-target group ( 34.0 % ) ( hazard ratio in the high-target group , 1.07 ; 95 % confidence interval [ CI ] , 0.84 to 1.38 ; P = 0.57 ) .