The point estimates ( PEs ) of the Test/Reference ( T/R ) adjusted geometric mean ratios of AUC ( 0-last ) , AUC ( 0 - ) , and C ( max ) were 99.20 % , 101.42 % , and 104.11 % , respectively , and all of them showed 90 % - confidence intervals ( CIs ) within the range of 80.00 - 125.00 % as suggested by regulatory requirements for bioequivalence assessment In total , 21 subjects experienced 55 AEs during the study , the most frequently reported AE , i.e. , headache , accounted for 13 out of the total 55 AEs ( 23.6 % ) and no AEs of severe intensity were reported .