Thrombocytopenia ( S-1 : 9.2 % , capecitabine : 1.4 % ; P = 0.040 ) and nausea ( S-1 : 26.2 % , capecitabine : 14.1 % ; P = 0.079 ) were more frequent in the S-1 group , while hand-foot syndrome occurred more often in the capecitabine group ( S-1 : 10.8 % , capecitabine : 25.4 % ; P = 0.029 ) .