Patients with higher VEGF-D expression received less benefit ( VEGF-D 2 PFS HR , 0.67 ; 95 % CI , 0.451.00 ; OS HR , 0.82 ; 95 % CI , 0.521.30 ; VEGF-D 3 PFS HR , 0.77 ; 95 % CI , 0.501.17 ; OS HR , 1.28 ; 95 % CI , 0.792.09 ) ( P interaction o0 .05 ) .