A significant interaction grouptime effect was found for pain on HRQOL ( F2 ,78 = 3.507 ; P = .035 ; partial 2 = .087 ) , clinical severity ( F2 ,78 = 5.231 ; P = .007 ; partial 2 = .118 ) , especially for venous edema ( assessed with the VCSS ) , fatigue ( F1 .67,65.21 = 4.690 ; P = .012 ; partial 2 = .107 ) , and heaviness ( F1 .57,61.32 = 9.702 ; P = .001 ; partial 2 = .199 ) , with the experimental group improving from t0 to t1 and t0 to t2 in all of these outcomes .