Key secondary outcomes were analyzed in the following prespecified sequential order : MADRS response ( 50 % decrease from baseline in total score ) , Clinical Global Impressions-Improvement score , change from baseline in MADRS total score in subjects with baseline Hamilton Anxiety Rating Scale score 20 , MADRS remission ( total score 10 ) , and change from baseline in Sheehan Disability Scale total score ( all at week 8 ) .