Rate of PAH-related hospitalizations and numbers of hospital days were reduced by 44.5 % ( p = 0.0004 ) and 53.3 % ( p = 0.0001 ) , respectively , with 3 mg of macitentan , and reduced by 49.8 % ( p < 0.0001 ) and 52.3 % ( p = 0.0003 ) , respectively , with 10 mg of macitentan .