Comparing intact tablets , the drug liking E ( max ) ( median [ 95 % CI ] ) was significantly lower for IR/ER HB/APAP 45/1950 mg ( 78.0 [ 73.0 , 81.0 ] ) than an equal dose of IR HB/APAP ( 89.5 [ 85.0 , 93.0 ] ; difference , -8.5 [ -12.0 , -6.0 ] ; P < 0.001 ) .