At steady state , insulin concentration ( INS ) and glucose infusion rate ( GIR ) profiles of Gla-300 were more constant and more evenly distributed over 24 h compared with those of Gla-100 and lasted longer , as supported by the later time ( 3 h ) to 50 % of the area under the serum INS and GIR time curves from time zero to 36 h post dosing .