Non-significant trends towards fewer CVD events with greater BP reductions are evident : hazard ratios ( HR ) 0.82 [ 95 % confidence interval ( CI ) : 0.37-1 .81 ] for 3.5 mm Hg SBP reduction ; HR 0.45 ( 95 % CI : 0.19-1 .04 ) for 6.8 mm Hg ; and HR 0.25 ( 0.05-1 .18 ) for 10.3 mm Hg reduction for primary composite of CV death , MI , stroke , or significant heart failure .