The time to 1 mm ST segment depression increased significantly in the fluvastatin-treated group ( from 24197 to 410140 s , P < 0.05 ) , the diltiazem-treated group ( from 25891 to 392124 s , P < 0.05 ) , and the fluvastatin + diltiazem-treated group ( from 250104 to 446164 s , P < 0.05 ) .