Moderate or severe aortic regurgitation occurred in 40 ( 14 % ) of 280 patients in the TAVR group and two ( 1 % ) of 228 in the SAVR group ( p < 00001 ) , and was associated with increased 5-year risk of mortality in the TAVR group ( 724 % for moderate or severe aortic regurgitation vs 566 % for those with mild aortic regurgitation or less ; p = 0003 ) .