The high-dose group also showed a significantly better decreases in serum BUN levels ( 35.1 8.6 to 30.2 6.3 mmol/L vs.low-dose group : 43.2 10.9 to 35.1 7.6 mmol/L , t = 3.200 , 5.901 , P = 0.043 , 0.047 ) and in serum Cr values ( 219.0 35.1 to 128.2 41.6 vs.low-dose group : 230.3 82.1 to 151.5 38.7 , t = 2.997 , 5.765 , P = 0.036 , 0.046 ) .