Recently , we documented the likely non-inferiority of Combinatietherapie Bij Reumatode Artritis ( COBRA ) - light therapy ( methotrexate increased to 25mg/week with initial prednisolone 30mg/day ) compared with the original COBRA therapy ( methotrexate 7.5 mg/week , sulfasalazine 2g/day , with initial prednisolone 60mg/day ) after 26weeks in patients with early active rheumatoid arthritis ( RA ) .