Risk factors for early termination were higher age ( hazard ratio [ HR ] 1.03 , 95 % confidence interval [ 95 % CI ] 1.02-1 .04 ) , functional disability during the preceding year ( HR 1.54 , 95 % CI 1.20-1 .99 ) , having achieved drug-free remission ( HR 6.62 , 95 % CI 2.07-21 .14 ) , limited joint damage ( HR 0.98 , 95 % CI 0.97-0 .995 for actual damage ; HR 0.83 , 95 % CI 0.73-0 .94 for damage progression ) , and few adverse events ( HR 0.35 , 95 % CI 0.26-0 .47 ) .