Children randomized to DP had a lower incidence of all treatments for malaria ( incidence rate ratio [ IRR ] , 0.85 ; 95 % CI , .75 -.96 ; P = .01 ) , complicated malaria ( IRR , 0.12 ; 95 % CI , .04 -.39 ; P < .001 ) , and hospitalizations ( IRR , 0.31 ; 95 % CI , .13 -.77 ; P = .01 ) .