Mean diastolic BP decreases of -2.1 ( 95 % CI -4.1 , -0.1 ) to -4.2 ( -7.5 , -0.9 ) mmHg in arm 1 and -3.0 ( -5.7 , -0.3 ) to -4.2 ( -7.4 , -1.0 ) mmHg in arm 2 were observed , statistically significant ( p < 0.05 ) at several time points , not accompanied by orthostatic symptoms or increases in positive orthostatic stress tests .