After the first patch application , the active group showed significantly higher cortisol concentrations than the placebo group , both at noon-2 .39 0.17 ng/mL vs 2.15 0.27 ( P = .0360 ) , respectively-and at 4:00 PM - 2.02 0.24 vs 1.67 0.31 ( P = .0155 ) , respectively .