Mean ( SE ) reductions from baseline in MADRS total score ( week 8 ) were -10.77 ( 0.807 ) , -12.96 ( 0.832 ) , and -14.41 ( 0.845 ) for the placebo , vortioxetine 10 mg ( P = .058 vs placebo ) , and vortioxetine 20 mg ( P = .002 vs placebo ) groups .