Inflammatory factors ( including interleukin-1 , interleukin-6 , tumor necrosis factor-alpha ) and coagulation parameters [ including prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen ( FIB ) , and D-dimer ( DD ) ] were observed before treatment , and 3 , 7 , and 14 days after treatment in the two groups .