After an average of 30 months , the mean SE decline in GFR was significantly greater with warfarin ( -3.68 0.24 ml/min ) compared with DE 110 mg ( -2.57 0.24 ml/min ; p = 0.0009 vs. warfarin ) and DE 150 mg ( -2.46 0.23 ml/min ; p = 0.0002 vs. warfarin ) .