The overall effects showed that food intake reduced the mean Cmax ( INH : 40.6 % , RIF : 40.2 % , EMB 34.4 % , PZA : 24.4 % ) and AUC0-10 ( INH : 21.3 % , RIF : 26.4 % , EMB : 12.2 % , PZA : 12.0 % ) .