Rates of all-cause hospitalizations and numbers of hospital days were reduced by 20.5 % ( p = 0.0378 ) and 30.6 % ( p = 0.0278 ) , respectively , with 3 mg of macitentan and by 33.1 % ( p = 0.0005 ) and 31.0 % ( p = 0.0336 ) , respectively , with 10 mg of macitentan .