HSV-2 / HIV co-infection was common in both time periods , with an average ( over the two time periods ) of 80 % of HIV negative females infected with HSV-2 , an average of 43 % of HIV negative males infected with HSV-2 ; an average of 97 % of HIV positive females also infected with HSV-2 and an average of 67 % of HIV positive males also infected with HSV-2 .