Mean calculated creatinine clearance was significantly lower in group B versus the average of groups A and C means throughout 60 months posttransplant ( 62.94.2 vs. 83.66.9 and 79.85.9 at 60 months , P = 0.01 ) , and death-censored graft failure was significantly higher in group B ( 13/43 ) versus groups A ( 5/43 ) and C ( 5/42 ) combined ( P = 0.009 ) .