However , I30/G30 , AUCCP180 and Matsuda index were only significantly increased in patients treated with LIRA ( respectively , 4.88 1.55 vs 7.601.91 , 9.23 2.66 vs 13.18 2.72 , 39.28 20.35 vs 54.64 23.34 , all P < 0.01 ) , while HOMA-IR reduced ( 4.41 1.58 vs 3.52 1.44 , P < 0.05 ) .