In this multicenter , open-label , randomized study , adults with hypertriglyceridemia undergoing lifestyle modification received TAK-085 2 g ( 2 g once daily ; n = 165 ) or 4 g ( 2 g twice daily ; n = 171 ) , or EPA-E 1.8 g ( 0.6 g three times daily ; n = 167 ) for 52 weeks .