There were significantly lower AZ ( 0.488 vs 0.745 [ mgh/L ] / [ mg/kg ] , p < 0.00001 ) and CQ ( 0.836 vs 1.27 [ mgh/L ] / [ mg/kg ] , p < 0.00001 ) exposures ( AUCinf ) normalized by dose ( mg/kg ) in children compared with the adults .