145 patients with Graves ' disease were randomly divided into 3 groups and all patients initially received 30mg of methimazole daily for at least 1 month and then followed the titration - regimen with or without L-thyroxine : group 1 ( 30mg20mg15mg10mg5mg ) ; group 2 ( 30mg20mg15mg10mg + L-thyroxine5mg + L-thyroxine ) ; group 3 ( 30mg20mg15mg10mg + L-thyroxine5mg + L-thyroxine2 .5 mg + L-thyroxine ) .