Between March 25 , 2011 , and March 12 , 2012 , 259 patients were randomly assigned to receive QVA149 and 264 to receive SFC. At week 26 , FEV1 AUC0-12h was significantly higher with QVA149 than with SFC ( treatment difference 0138 L ; 95 % CI 0100-0176 ; p < 00001 ) .