The polyphenols with the strongest inverse associations were flavanols ( HR = 0.40 ; CI 0.23-0 .72 ; P-trend = 0.003 ) , lignans ( HR = 0.51 ; CI 0.30-0 .86 ; P-trend = 0.007 ) , and hydroxybenzoic acids ( HR = 0.47 ; CI 0.26-0 .86 ; P-trend 0.02 ) .