In patients with lung infection ( N = 744 ) , abdominal infection ( N = 510 ) , Gram-positive sepsis ( N = 420 ) and Gram-negative sepsis ( N = 461 ) , the propensity weighted risk of 28-day as well as 90-day mortality in those treated vs. those not treated with steroids did not differ among those randomized to DrotAA vs. placebo nor was a difference detected within each randomized treatment .