OPA titers following PPSV23 given 1 year after PCV13 ( PCV13/PPSV23 ) ( a ) were noninferior for the 12 common serotypes and significantly higher for 6 of 12 common serotypes than those following only an initial PPSV23 ; and ( b ) were significantly higher for 11 of 12 common serotypes compared with PPSV23 followed by PCV13 ( PPSV23/PCV13 ) .