In analyses restricted to eyes with bilateral large drusen at baseline , the direct comparison of lutein/zeaxanthin vs beta carotene showed hazard ratios of 0.76 ( 95 % CI , 0.61-0 .96 ; P = .02 ) for progression to late AMD , 0.65 ( 95 % CI , 0.49-0 .85 ; P = .002 ) for neovascular AMD , and 0.98 ( 95 % CI , 0.69-1 .39 ; P = .91 ) for central geographic atrophy .