Based on the intention-to-treat population , DC was 85 % ( 95 % CI 73-93 % ) , 40 % ( 95 % CI 19-64 % ) , and 58 % ( 95 % CI 41-73 % ) in patients treated with multiple doses ( n = 63 ) , and single doses of 75 ( n = 21 ) or 10 mg/kg ( n = 40 ) , respectively .