The cumulative incidence of grade 2 or worse acute gastrointestinal toxicity by 120 days after radiotherapy was higher in patients given hypofractionation ( 312 % [ 95 % CI 266-358 ] in the standard fractionation group vs 420 % [ 372-469 ] in the hypofractionation group ; difference 108 % , 90 % CI 525-1643 ; OR 16 ; p = 00015 ; non-inferiority not confirmed ) .