Mean ( 95 % CI ) change from baseline in ISI at week 8 was -4.1 points ( -5.3 to -3.0 ) with estradiol , -5.0 points ( -6.1 to -3.9 ) with venlafaxine , and -3.0 points ( -3.8 to -2.3 ) with placebo ( P overall treatment effect vs. placebo 0.09 for estradiol and 0.007 for venlafaxine ) .