At baseline , cystatin C was positively correlated with high-sensitivity C-reactive protein ( Spearman r = 0.25 ) , interleukin 6 ( r = 0.34 ) , soluble intercellular adhesion molecule ( r = 0.36 ) , soluble vascular cell adhesion molecule ( r = 0.54 ) , tumor necrosis factor ( r = 0.57 ) , and soluble TNF - receptor I ( r = 0.70 , all P < 0.001 ) .