High levels ( > 10.3 mol/L ) of serum homocysteine were independent predictors for END ( third quartile odds ratio , 3.45 ; 95 % confidence intervals , 1.25-9 .50 ; P = 0.016 ; fourth quartile odds ratio , 3.36 ; 95 % confidence intervals 1.18-9 .52 ; P = 0.023 ) in multivariate analysis .