High-order gene-gene interaction analysis , using classification and regression tree ( CART ) and multifactor dimensionality reduction ( MDR ) revealed that AT1 A1166C and NFKB1-94 ATTG ins/del polymorphisms jointly increased the risk of LVD to great extent ( p-value = 0.001 ; OR = 8.55 ) and best four-factor interaction model consisted of AT1 A1166C , MMP7 A-181G , MMP9 R668Q and NFKB1-94 ATTG ins/del polymorphisms with testing accuracy of 0.566 and cross validation consistency ( CVC ) = 9/10 ( permutation p < 0.001 ) showed increased risk for LVD respectively .