Mean estimated glomerular filtration rate change from baseline to end of follow-up was -2.7 % ( 95 % confidence interval : -7.7 , 2.4 ) with aleglitazar versus -3.4 % ( 95 % confidence interval : -8.5 , 1.7 ) with pioglitazone , establishing non-inferiority ( 0.77 % ; 95 % confidence interval : -4.5 , 6.0 ) .