TIMP2 expression and risk score for early relapse ( which is calculated using values of VEGFA and TIMP2 ) were independent prognostic factors for overall survival ( p = 0.043 , HR = 0.96 , 95 % CI = 0.93-0 .99 and p = 0.002 , HR = 1.09 , 95 % CI = 1.03-1 .15 , respectively ) .