Insulin ( LS : -1 U/mg [ not significant ] ; MR : -6.3 U/mg , P < 0.01 ) and homeostasis model assessment of insulin resistance ( HOMA-IR ; LS -0.92 , P < 0.01 ; MR : -2.1 , P < 0.01 ) were also significantly lower following both interventions ; again improvements were more pronounced in the MR group ( insulin : P < 0.05 ; HOMA P < 0.01 ) CONCLUSION : It can be concluded that meal replacement is an effective intervention for rapid improvement of elevated fasting glucose and increased insulin concentrations , these being important biomarkers of the prediabetic state .