Exposure to empagliflozin was increased by coadministration with gemfibrozil ( AUC0 - : geometric mean ratio [ GMR ] , 158.50 % [ 90 % CI , 151.77-165 .53 ] ; Cmax : GMR , 115.00 % [ 90 % CI , 106.15-124 .59 ] ) , rifampicin ( AUC0 - : GMR , 135.20 % [ 90 % CI , 129.58-141 .06 ] ; Cmax : GMR , 175.14 % [ 90 % CI , 160.14-191 .56 ] ) , and probenecid ( AUC0 - : GMR , 153.47 % [ 90 % CI , 146.41-160 .88 ] ; Cmax : GMR , 125.60 % [ 90 % CI , 113.67-138 .78 ] ) .