Uric acid clearance decreased significantly in GTE2 ( from 11.37 6.41 mL/min per 1.73 m to 7.44 2.74 mL/min per 1.73 m , 34.56 % , P < 0.05 ) and GTE4 ( from 8.36 3.41 mL/min per 1.73 m to 5.78 2.33 mL/min per 1.73 m , 30.86 % , P < 0.05 ) .