Initial analyses adjusted for sex , age and treatment allocation showed significantly reduced hazard ratios of 0.80 ( 95 % confidence interval 0.68-0 .94 ) , 0.73 ( 0.62-0 .86 ) and 0.77 ( 0.65-0 .91 ) , for the three higher total bilirubin groups : > 8 and 10 mol/L , > 10 and 13 mol/L and > 13 mol/L ( 5-95 interpercentile range for total bilirubin at screening ; 6-19 mol/L ) , compared to the lowest total bilirubin group 8 mol/L .