The purpose of this study was to assess the efficacy and safety of FOLFOX4 , comprising infusional 5-fluorouracil ( 5-FU ) / leucovorin ( LV ) and oxaliplatin , with cetuximab compared with UFOX , comprising UFT , an oral prodrug of 5-FU , LV , and oxaliplatin , with cetuximab as first-line treatment for mCRC .