A high concentration ( quartile 4 vs. quartiles 1 to 3 ) of each biomarker identified an increased risk of CV death or HF ( copeptin : 13.2 % vs. 5.0 % , p < 0.001 ; MR-proADM : 15.8 % vs. 4.1 % , p < 0.001 ; MR-proANP : 17.7 % vs. 3.5 % , p < 0.001 ) as well as CV death , HF , and myocardial infarction individually ( all p 0.001 ) .