Of 3016 SNPs evaluated , eight were significantly associated with fibrosis risk ( e.g. , SFRP2 rs11937424 : OR = 2.19 , 95 % CI 1.48-3 .23 , P = 0.00004 ) , and seven were significantly associated with inflammation risk ( e.g. , SFRP1 rs16890282 : OR = 2.15 , 95 % CI 1.39-3 .16 , P = 0.0004 ) .