A total of 141 intravitreal injections of anti-vascular endothelial growth factor drugs ( 0.05 mL ) were randomly distributed into 2 groups : in group 1 ( n = 77 ) , no prophylactic IOP-lowering medication was used ; in group 2 ( n = 64 ) , a fixed combination of brimonidine and timolol was instilled 5 minutes before the injection .