Supportive end points included mean diurnal IOP change from baseline at week 2 , week 6 , and month 6 ; and mean IOP , mean IOP change from baseline , mean percentage IOP change from baseline , and percentage of patients with IOP < 18 mmHg at week 2 , week 6 , month 3 , and month 6 at each assessment time point ( i.e. , 9 am , 11 am , and 4 pm ) .