The IELT was dramatically prolonged in groups A , B , and C after treatment ( [ 3.23 1.84 ] , [ 3.87 2.43 ] , and [ 5.92 3.11 ] min ) and at 1 month after drug withdrawal ( [ 1.85 1.27 ] , [ 1.52 1.06 ] , and [ 4.26 1.88 ] min ) as compared with the baseline ( [ 0.88 0.45 ] , [ 0.84 0.47 ] , and [ 0.85 0.50 ] min ) ( P < 0.01 ) , even longer in group C than in A and B ( P < 0.01 ) .