Compared with TO in the same group , WBC , N , CRP , ESR , IL-6 , PT , TT , and D-D all increased in the control group at T1-T4 ( P < 0.05 ) ; APTT increased at T1-T2 ( P < 0.05 ) ; FIB increased at T1-T3 ( P < 0.05 ) .