In a multiple regression model , the G allele was associated directly with aspartate aminotransferase ( = 2.60 ; 95 % CI : 0.99 , 4.20 ) , alanine aminotransferase ( = 3.70 ; 95 % CI : 1.78 , 5.62 ) , and - glutamyl transferase ( = 3.70 ; 95 % CI : 0.80 , 6.60 ) and inversely with insulin ( = -2.01 ; 95 % CI : -3.24 , -0.78 ) and HOMA-IR ( = -0.39 ; -0.64 , -0.14 ) values at the end of the trial .