We recorded no between-group difference in the primary endpoint : participants in the ATG group had a mean change in C-peptide area under the curve of -0.195 pmol/mL ( 95 % CI -0.292 to -0.098 ) and those in the placebo group had a mean change of -0.239 pmol/mL ( -0.361 to -0.118 ) in the placebo group ( p = 0.591 ) .