In the low-dose group , the area under the curve of estradiol concentrations adjusted by creatinine are ( 6838.21 2573.89 ) , ( 6611.33 1648.21 ) and ( 5949.24 1437.54 ) / The area under the curve of pregnanediol concentrations adjusted by creatinine are ( 49.25 15.68 ) , ( 48.79 15.61 ) and ( 43.45 12.77 ) .