L-NMMA was associated with a significant decrease in RPF ( CON-LNMMA : -13 3 % [ P = .014 ] ; CHF-LNMMA : -17 7 % [ P = .017 ] ) and a profound increase in RVR in both CHF and CON ( CON-LNMMA : +26 6 % [ P = .009 ] ; CHF-LNMMA : +37 70 % [ P = .005 ] ) .