Women with past PMD who were crossed over from estradiol to placebo experienced a significant increase in depression symptom severity demonstrated using the Center for Epidemiologic Studies-Depression Scale and 17-item Hamilton Depression Rating Scale , with mean ( SD ) scores increasing from estradiol ( ie , 2.4 [ 2.0 ] and 3.0 [ 2.5 ] ) to placebo ( 8.8 [ 4.9 ] and 6.6 [ 4.5 ] , respectively [ P = .0004 for both ] ) .