The mean 2 h C-peptide AUC at 12 months increased by 0.015 nmol/L ( 95 % CI -0.080 to 0.110 ) in the alefacept group and decreased by 0.115 nmol/L ( -0.278 to 0.047 ) in the placebo group , and the difference between groups was not significant ( p = 0.065 ) .