The following significant changes were observed during the course of the study : ( 1 ) physical symptom score , hot flash score , and ( 2 ) Athens Insomnia Scale score decreased in the high-dose group after 8 weeks of treatment ; ( 3 ) Hospital Anxiety and Depression Scale Anxiety score and ( 4 ) systolic and diastolic blood pressure decreased in the low-dose and high-dose groups after 4 weeks ; and , ( 5 ) lastly , muscle mass increased in the low-dose and high-dose groups after 8 weeks of treatment .