Combined treatment enhanced the rate of recovery vs treatment with ADM alone ( 72.6 % vs 62.5 % ; t451 = 2.45 ; P = .01 ; hazard ratio [ HR ] , 1.33 ; 95 % CI , 1.06-1 .68 ; number needed to treat [ NNT ] , 10 ; 95 % CI , 5-72 ) .