Patients were randomised to Arm A : gemcitabine 1000mg/m ( 2 ) ( days 1 and 8 ) plus either cisplatin ( 70mg/m ( 2 ) ) or carboplatin ( AUC = 5 ) ( day 1 every 3 weeks ) or Arm B : added trastuzumab ( 8mg/kg loading dose , then 6 mg/kg every 21 days until progression ) .