The Colgate ProClinicaI C200 toothbrush , with either a triple clean head or a sensitive head , provides statistically significant and clinically relevant levels of efficacy in the removal of supragingival dental plaque in the whole mouth , at the gingival margin , and interproximally after a single tooth brushing and after four weeks of use , as well as a statistically significantly greater level of efficacy in the reduction of gingivitis and gingival bleeding when compared to a manual flat-trim toothbrush .