In breakfast meal test patients , lixisenatide reduced 2-hour PPG versus placebo ( LS mean : -111.48 vs. -3.80 mg/dL [ -6.19 vs. -0.21 mmol/L ] ; p < 0.0001 ) and glucose excursion ( -94.11 vs. +6.24 mg/dL [ -5.22 vs. +0.35 mmol/L ] ) , and reduced 2-hour glucagon , insulin , proinsulin , and C-peptide .