Annual rates of stroke or systemic embolism ranged from 0.9 % to 2.03 % ( P < 0.001 ) ; of major bleeding , from 1.22 % to 4.53 % ( P < 0.001 ) ; and of mortality , from 1.34 % to 7.19 % ( P < 0.001 ) in the lowest compared with the highest GDF-15 quartile .