Change rate of IMT statistical positively related to descent rates of Th17 cells frequency , IL-17 , IL-6 , IL-23 , TNF - , expression of RORt mRNA , Th17/Treg ratio , IL-1 , IL-2 , IFN - , hsCRP , and MCP-1 , and negatively related to increased rates of Treg frequency , IL-10 , TGF-1 , and expression of Foxp3 mRNA , respectively ( all P < 0.05 ) .