Mean ( 95 % CI ) change from baseline in PSQI at week 8 was -2.2 points ( -2.8 to -1.6 ) with estradiol , -2.3 points ( -2.9 to -1.6 ) with venlafaxine , and -1.2 points ( -1.7 to -0.8 ) with placebo ( P overall treatment effect vs. placebo 0.04 for estradiol and 0.06 for venlafaxine ) .