There was no suggestion of a beneficial effect on the main outcome at six ( SVP versus UC : odds ratio ( OR ) 0.94 , 95 % CI : 0.46 to 1.94 ; SVP + versus UC : OR : 0.62 , 95 % CI : 0.28 to 1.37 ) or 12 weeks ( SVP versus UC : OR : 1.02 , 95 % CI : 0.54 to 1.93 ; SVP + versus UC : OR : 1.06 , 95 % CI : 0.54 to 2.09 ) .