There were significant differences between GSTM1-null/GSTT1 + individuals for several biomarkers in response to 1xC + A compared with basal diets ( CRP : -37.8 % ; 95 % CI : -58.0 % , -7.4 % ; IL-6 : -48.6 % ; 95 % CI : -49.6 % , -12.0 % ; IL-8 : 16.3 % ; 95 % CI : 6.7 % , 57.7 % ) and with the 2xC diet compared with the basal diet ( IL-8 : -33.2 % ; 95 % CI : -43.0 % , -1.4 % ; sTNFRI : -7.5 % ; 95 % CI : -12.7 % , -2.3 % ) .