Hindlimb unloading for 14 days resulted in 25.9 % decrease in total bone mineral content ( BMC ) , 29.2 % decrease in trabecular BMD and trabecular microarchitecture and connectivity were significantly deteriorated in the proximal tibia metaphysis in HU group , while rats with ES at DRG showed significant reduced bone loss that there was 3.8 % increase in total BMC , 2.3 % decrease in trabecular BMD , and significant improvement in trabecular microarchitecture .