In the final multivariable model , the presence of an antisynthetase , primarily anti-Jo-1 ( hazard ratio [ HR ] 3.08 , P < 0.01 ) , anti-Mi-2 ( HR 2.5 , P < 0.01 ) , or other autoantibody ( HR 1.4 , P = 0.14 ) predicted a shorter time to improvement compared to the absence of autoantibodies .