The geometric mean ratio and its 90 % confidence interval of once-daily ER itopride versus IR itopride three times a day for AUC ( 0-24h ) were contained within the conventional bioequivalence range of 0.80-1 .25 ( 0.94 [ 0.88-1 .01 ] ) , although Cmax was reached more slowly and was lower for itopride ER than for the IR formulation .