The following correlation analyses were performed : ( 1 ) response evaluation criteria in solid tumors-defined tumor response with serum soluble protein levels via two distinct multiplex ( n < 1,000 ) platforms ; ( 2 ) response and time-to-event outcomes with germ line SNPs in vascular endothelial growth factor ( VEGF ) - A and VEGF receptor ( VEGFR ) 3 genes ; and ( 3 ) response and time-to-event outcomes with tumor immunohistochemistry status for hypoxia-inducible factor 1-alpha ( HIF-1 ) and carbonic anhydrase-IX or tumor Von Hippel-Lindau ( VHL ) gene inactivation status .