There were no significant differences in the TD-MPI ( HS vs. mannitol : 0.43 vs. 0.44 [ baseline ] , 0.45 vs. 0.43 [ 15 min ] , 0.44 vs. 0.45 [ 30 min ] , 0.47 vs. 0.45 [ 60 min ] , 0.45 vs. 0.46 [ 120 min ] ) , E/A ratio , IVCT , and E/E ' either within or between the 2 groups at any time point .