This observer-blind study , conducted in the United States ( US ) and Spain during the 2008-2009 influenza season , evaluated the effect of Adjuvant System AS03 on specific T-cell responses to a seasonal trivalent influenza vaccine ( TIV ) in 65 year-old adults.Medically-stable adults aged 65 years were randomly allocated to receive a single dose of AS03-adjuvanted TIV ( TIV/AS03 ) or TIV .