When parental NDMs were examined alone , the prevalence of Generation 3 MVP remained higher ( 12 of 484 , 2.5 % ) compared with those without parental MVP or NDMs ( 27 of 3009 , 0.9 % ; adjusted odds ratio , 2.52 ; 95 % confidence interval , 1.25-5 .10 ; P = 0.01 ) .