With use of once - and twice-daily insulin , HbA1c values were decreased by 1.8 % ( 2.0 ) and 1.5 % ( 1.4 ) within the first 12 weeks ( p < 0.01 ) , whereas increased by 0.21 % ( 0.7 ) and 0.14 % ( 0.8 ) in the second 12 weeks ( p > 0.05 ) .