Human immunodeficiency virus ( HIV ) - negative women 18-45 years old with 1 or more vaginal infections , including bacterial vaginosis ( BV ) , vulvovaginal candidiasis ( VVC ) , or Trichomonas vaginalis ( TV ) , were randomly assigned to receive vaginal suppositories containing metronidazole 750 mg plus miconazole 200 mg or matching placebo for 5 consecutive nights each month for 12 months .