Aripiprazole produced greater improvement than placebo in the MADRS total score regardless of MDD severity at baseline ( between-treatment difference [ 95 % CI ] : mild , -2.5 [ -4.0 to -1.1 ] ; moderate , -3.2 [ -4.9 to -1.6 ] ; severe , -4.5 [ -6.8 to -2.2 ] ) .