Erythrocyte folate concentration was directly associated with increased risk of overall skin cancer ( HR ( T3vs.T1 ) : 2.54 ; 95 % CI : 0.95 , 6.81 ; P-trend = 0.03 ) , NMSC ( HR ( T3vs.T1 ) : 3.49 ; 95 % CI : 1.11 , 11.0 ; P-trend = 0.01 ) , and BCC ( HR ( T3vs.T1 ) : 7.44 ; 95 % CI : 1.57 , 35.3 ; P-trend = 0.004 ) ( men and women combined ) .