The minor allele ( C ) of rs3212227 in IL12 ( p40 ) was associated with an increased risk of total ( log additive : OR = 1.30 , 95 % CI 1.10-1 .53 ; P-trend = 0.0017 ) and lower-grade ( OR = 1.36 , 95 % CI 1.15-1 .62 ; P-trend = 0.0004 ) prostate cancer .