After adjusting for age , sex and race , one interquartile range higher log10-transformed sRAGE was associated with development of CKD [ odds ratio : 1.39 ; 95 % confidence interval ( 95 % CI ) 1.06-1 .83 ; P = 0.02 ] and ESRD ( hazard ratio : 1.97 ; 95 % CI 1.47-2 .64 ; P < 0.001 ) .