Plasma-free cortisol , plasma total cortisol , and plasma-free cortisol/plasma total cortisol were positively correlated with interleukin-6 ( p = 0.0001 , p < 0.0004 , and p < 0.001 , respectively ) and day 90 mortality ( p = 0.03 , p = 0.03 , and p = 0.058 , respectively ) .