Prospectively , lower baseline HDL-C and HDL-C/apoA-I levels predicted greater uptake ( per 1-SD lower : hazard ratio [ HR ] 1.13 [ CI 1.07-1 .19 ] , P < 0.001 ; and HR 1.16 [ CI 1.10-1 .23 ] , P < 0.001 , respectively ) and earlier uptake ( median 12.9 and 24.0 months , respectively , for quartile 1 vs. quartile 4 ; both P < 0.01 ) of OHAs and insulin , with no difference in HbA1c thresholds for initiation ( P = 0.87 and P = 0.81 ) .