Moreover , there was no difference in the percentage of patients with an IFN signature response between those who remained vitamin D deficient and those who demonstrated repletion of vitamin D. Modular microarray analysis of a subset of patients ( n = 40 ) did not reveal changes from baseline in any modules ( including the IFN-inducible module ) in any of the treatment groups , and no differences in expression were found between patients who demonstrated vitamin D repletion and patients who were persistently vitamin D deficient .