In the 2-3 N ( t ) RTI group ( vs. RAL ) , BMD reduction was greater at the spine ( mean change , -4.9 % vs. -3.5 % ; adjusted difference , -1.9 % ; 95 % confidence interval : -3.3 to -0.5 % , P = 0.009 ) and hip ( -4.1 % vs. -2.2 % ; -1.9 % ; -3.4 to -0.4 ; P = 0.012 ) .