During the 2-year follow-up , patients with reduced LTPA at baseline had an increased risk of CV events ( adjusted hazard ratio 2.3 [ 95 % CI 1.1-5 .1 ; P = 0.033 ] , 2.1 [ 1.1-4 .2 ; P = 0.027 ] , and 2.0 [ 1.0-3 .9 ; P = 0.044 ] for no LTPA , LTPA irregularly , and LTPA two to three times weekly , respectively ) compared with those with LTPA more than three times weekly .