The changes for CAL were as follows ( mm , 95 % CI ) : at 1 year : EF ( 4.1 mm , 3.8 to 4.5 ) , ED ( 3.5 mm , 3.0 to 4.0 ) , and E ( 3.0 mm , 2.5 to 3.6 ) ; at 3 years : EF ( 4.2 mm , 3.7 to 4.7 ) , ED ( 3.6 mm , 3.1 to 4.1 ) , and E ( 3.0 mm , 2.5 to 3.5 ) .