Among patients with baseline galectin-3 levels in the top quartile of the distribution , CRT-D was associated with a 65 % reduction in risk of the primary end point ( hazard ratio [ HR ] 0.35 , 95 % confidence interval [ CI ] 0.19-0 .67 ) , whereas among patients with lower baseline galectin-3 values CRT-D was associated with a 25 % decrease in risk ( HR 0.75 , 95 % CI .