More grade 3-4 neurotoxic events ( seven [ 7 % ] vs one [ 1 % ] ) and haematotoxic events occurred in the Unfav-dose-dense group compared with in the Unfav-BEP group ; there was no difference in grade 1-2 febrile neutropenia ( 18 [ 17 % ] vs 18 [ 18 % ] ) or toxic deaths ( one [ 1 % ] in both groups ) .