In this prospective , multicenter , open-labeled , randomized trial , the antialbuminuric effects of benidipine and hydrochlorothiazide were examined in renin-angiotensin system ( RAS ) inhibitor-treated patients with blood pressure ( BP ) readings of 130/80 mmHg and 180/110 mmHg , a urinary albumin to creatinine ratio ( UACR ) of 300 mg/g , and an estimated glomerular filtration rate ( eGFR ) of 30 ml/min/1 .73 m ( 2 ) .