Volumetric ADC increased significantly ( 1.3210 ( -3 ) mm ( 2 ) / sec to 1.6010 ( -3 ) mm ( 2 ) / sec , p < 0.001 ) , and volumetric enhancement decreased significantly in HAP ( 38.2 % to 17.6 % , p < 0.001 ) and PVP ( 76.6 % to 41.2 % , p < 0.005 ) .