Secondary and safety outcomes included invasive candidiasis , liver function , bacterial infection , length of stay , intracranial hemorrhage , periventricular leukomalacia , chronic lung disease , patent ductus arteriosus requiring surgery , retinopathy of prematurity requiring surgery , necrotizing enterocolitis , spontaneous intestinal perforation , and neurodevelopmental outcomes-defined as a Bayley-III cognition composite score of less than 70 , blindness , deafness , or cerebral palsy at 18 to 22 months corrected age .