The risk of LR over a 10-year period among patients with high-risk lesions ( n = 683 ) was significantly higher ( LRFS = 91 % ) when compared with patients with low-risk lesions ( n = 641 ) ( 10-year LRFS = 97.5 % ) ( HR : 1.31 ( 1.16-1 .48 ) P < 0.005 ) .