In addition , with colesevelam there was an increase in total high-density lipoprotein ( HDL ) particle concentration versus placebo ( baseline : 31mol/L ; LS mean treatment difference : +0.6 mol/L , p = 0.20 ) , due to increases in the large ( baseline : 5mol/L ; LS mean treatment difference : +0.5 mol/L , p = 0.007 ) and medium ( baseline : 3mol/L ; LS mean treatment difference : +0.8 mol/L , p = 0.02 ) HDL subclasses .