In the multicenter Platelet Dose ( `` PLADO '' ) study , pediatric and adult hematology-oncology patients with hypoproliferative thrombocytopenia were randomized to receive low-dose ( LD ) , medium-dose ( MD ) , or high-dose ( HD ) PLT prophylaxis for a pretransfusion PLT count of not more than 1010 ( 9 ) / L. All PLT units ( apheresis or WBD ) were leukoreduced .