At week 48 , mean [ 95 % confidence interval ( CI ) ] HbA1c changes from baseline were -1.8 % ( -1.55 % to -2.05 % ) with exenatide , -1.7 % ( -1.52 % to -1.96 % ) with insulin and -1.5 % ( -1.23 % to -1.71 % ) with pioglitazone .