34 patients had complete 24-h BP readings ; compared with placebo , daglutril significantly reduced 24-h systolic ( difference -52 mm Hg , SD 94 ; p = 00013 ) , diastolic ( -25 , 62 ; p = 0015 ) , pulse ( -30 , 63 ; p = 0019 ) , and mean ( -31 , 62 ; p = 0003 ) BP , as well as all night-time BP readings and daytime systolic , pulse , and mean BP , but not diastolic BP .