In the Determining the Efficacy and Tolerability of cholesteryl ester transfer protein ( CETP ) INhibition with AnacEtrapib ( DEFINE ) trial , anacetrapib added to statin produced robust low-density lipoprotein cholesterol ( LDL-C ) - lowering and high-density lipoprotein cholesterol ( HDL-C ) - raising vs placebo in patients with coronary heart disease ( CHD ) .