In the EA group , Baseline AES scores did not differ between responders and nonresponders ( 14.8 vs 15.3 , P = .64 ) ; however , AES increased in responders compared with nonresponders over time ( P = .004 for responder and time interaction term ) with significant difference at the end of trial for responders versus nonresponders ( 16.2 vs 11.7 , P = .004 ) .