International randomized , double-blind , placebo-controlled study conducted among 130 patients with familial amyloid polyneuropathy exhibiting clinically detectable peripheral or autonomic neuropathy at amyloid centers in Sweden ( Ume ) , Italy ( Pavia ) , Japan ( Matsumoto and Kumamoto ) , England ( London ) , and the United States ( Boston , Massachusetts ; New York , New York ; and Rochester , Minnesota ) from 2006 through 2012 .