Residual geometric mean albuminuria with baseline treatment was 711 mg per day ( 95 % CI 485-1043 ) ; it was significantly reduced by sodium restriction ( 393 mg per day [ 258-599 ] , p = 00002 ) , by hydrochlorothiazide ( 434 mg per day [ 306-618 ] , p = 00003 ) , and to the greatest extent by their combination ( 306 mg per day [ 203-461 ] , p < 00001 ) .