The HBV DNA negative rates of the LDT and LDT + ADV groups were 62.7 % and 61.5 % ( X2 = 0.01 ) at week 24 , 76.0 % and 81.5 % ( X2 = 0.63 ) at week 48 , 80.0 % and 89.2 % ( X2 = 2.2 ) at week 96 , 78.3 % and 93.3 % ( X2 = 3.24 ) at week 144 , 83.7 % and 91.7 % ( X2 = 0.47 ) at week 192 , and 93.3 % and 88.9 % at week 240 ( comparison between two groups for each point P more than 0.05 ) ; both groups showed higher early and rapid sustained HBV DNA negative rates .