Alfaxalone : IOP did not change between BL ( 15.7 2.8 mmHg ) and postpremed ( 15.3 4.1 mmHg , P > 0.05 ) , or postinduct ( 19.2 4.9 mmHg ) and postintub ( 20.5 4.5 mmHg , P > 0.05 ) , but differed significantly between BL and postinduct ( P < 0.01 ) , and postintub ( P < 0.0001 ) .