Treatment with IFLshowed a trend toward increased overall survival for patients with CIMP-positive tumors , compared with treatment with fluorouracil and leucovorin ( hazard ratio = 0.62 ; 95 % CI : 0.37-1 .05 ; P = .07 ) , but not for patients with CIMP-negative tumors ( hazard ratio = 1.38 ; 95 % CI : 1.00-1 .89 ; P = .049 ) .