After a once daily treatment with prucalopride 2 mg ( n = 98 ) and 4 mg ( n = 70 ) , CTT was reduced by 12.0 h ( 95 % confidence interval ( CI ) : -18.9 , -5.1 ) and 13.9 h ( 95 % CI : -20.5 , -7.4 ) , respectively ; CTT increased by 0.5 h ( 95 % CI : -4.5 , 5.5 ) with placebo ( n = 112 ) .