At 6 and 12months , respectively , SGRQ was -12.112.9 and -11.113.3 points , 6MWD was +29.774.1 m and +51.476 m , FEV ( 1 ) was +0.110.20 L and +0.110.30 L , and RV ( residual volume ) was -0.650.90 L and -0.710.81 L ( all p < 0.01 ) .