Compared with placebo , apixaban increased Thrombolysis In Myocardial Infarction major bleeding in patients taking aspirin ( 1.48 vs. 0.25 ; adjusted HR : 6.62 ; 95 % CI : 0.75 to 51.73 ) and in patients taking aspirin plus clopidogrel ( 2.58 vs. 1.02 ; adjusted HR : 2.44 ; 95 % CI : 1.34 to 4.45 ; p ( interaction ) = 0.41 ) .