Also , pain/discomfort scores were lower with sublingual alprazolam compared with sublingual placebo ( 3.29 , SE 0.29 vs. 4.16 , SD 1.86 ; P = 0.024 ) , and with oral alprazolam compared with oral placebo ( 3.48 , SD 1.69 vs. 5.13 , SD 2.39 ; P < 0.001 ) .