The scores in Pittsburgh sleep quality index ( PSQI ) and Asberg rating scale for side effects ( SERS ) , the levels of neurotransmitters such as 5-hydroxy tryptamine ( 5-HT ) and norepinephrine ( NE ) and the expressions of protein kinase C ( PKC ) and brain-derived neurotrophic factor ( BDNF ) in peripheral blood were observed before and after treatment in the two groups .