Patients were randomized to receive either tamoxifen 20 mg/day plus tegafur-uracil 400 mg/day ( TU ) for 2 years or six courses of a 28-day cycle of doxorubicin 40 mg/m ( 2 ) plus cyclophosphamide 500 mg/m ( 2 ) on day 1 along with tamoxifen ( ACT ) given for 2 years as adjuvant therapy .