Patients were randomly assigned to receive four cycles of PEB every 3 weeks or two cycles of PEB followed by a high-dose sequence ( HDS ) comprising HD-cyclophosphamide ( 7.0 g/m ( 2 ) ) , 2 courses of cisplatin and HD-etoposide ( 2.4 g/m ( 2 ) ) with stem-cell support , and a single course of HD-carboplatin [ area under the curve ( AUC ) 27 mg/ml min ] with autologous stem-cell transplant .