TIMP-1 concentrations were lower on postoperative day one , ( TIMP-1 [ ng/mL ] : 174 [ 55 ] versus 273 [ 104 ] , P = 0.003 ) , whereas MMP-3 levels were lower on postoperative days four and five ( MMP-3 [ ng/mL ] : 44 [ 17 ] versus 67 [ 35 ] , P = 0.026 ) .