Response rates were significantly higher with 25 mg of naloxegol than with placebo ( intention-to-treat population : study 04 , 44.4 % vs. 29.4 % , P = 0.001 ; study 05 , 39.7 % vs. 29.3 % , P = 0.02 ; patients with an inadequate response to laxatives : study 04 , 48.7 % vs. 28.8 % , P = 0.002 ; study 05 , 46.8 % vs. 31.4 % , P = 0.01 ) ; in study 04 , response rates were also higher in the group treated with 12.5 mg of naloxegol ( intention-to-treat population , 40.8 % vs. 29.4 % , P = 0.02 ; patients with an inadequate response to laxatives , 42.6 % vs. 28.8 % , P = 0.03 ) .