In a subset of patients in SENIORS we measured N-terminal pro-brain natriuretic peptide ( NT-BNP ) , pro atrial natriuretic peptide ( Pro-ANP ) , endothelin-1 ( ET-1 ) , peripheral norepinephrine ( PNE ) , soluble Fas ( sFas ) , soluble Fas-ligand ( sFas-L ) , tumour necrosis factor-alpha ( TNF - ) , serum uric acid ( SUA ) , symmetrical dimethyl arginine ( SDMA ) , arginine , citrulline and asymmetrical dimethyl arginine ( ADMA ) at baseline ( before study drug ) , at 6 months and 12 months in a prespecified substudy .