IDeg + Lira subjects had significantly less confirmed and nocturnal confirmed hypoglycaemia , and significantly greater weight loss ( -2.8 kg ) versus IDeg + IAsp ( +0.9 kg ) ; ETD ( IDeg + Lira-IDeg + IAsp ) -3.75 kg ( 95 % CI -4.70 ; -2.79 ) ; p < 0.0001 .