Between-group comparisons after the second course of treatment revealed that the symptom scores for group 1 ( 1 cone , 3 treatments/wk ) and group 3 ( 2 cones , 3 treatments/wk ) were significantly lower than that for group 2 ( 1 cone , 6 treatments/wk ) ( 5.55 5.05 vs 10.45 6.61 , P < 0.001 ; 5.65 4.00 vs 10.45 6.61 , P < 0.001 ) .