Planned sensitivity analyses of the primary outcome , using last value carried forward ( LVCF ) to handle missing data and using the completers ' only sample , suggested that the 15 mg dose is also futile ( p = 009 for LVCF , p = 009 for completers ) but failed to reject the null hypothesis for the 45 mg dose ( p = 012 for LVCF , p = 019 for completers ) .