Compared with the normal control group , FEV1 , MVV , PEF , FEF50 , FEF75 , SOD , CAT , TAOC , IL-4 , IL-10 were significantly lower , and NF-B p65 , iNOS , NO , ROS , RNS , MDA , IL-1 , TNF - , ESR , and Hs-CRP significantly higher in patients with AS ( P < 0.01 or P < 0.05 ) .