The time of eye opening and extubation were longer in group D0 .8 as compared with those in control and D0 .4 groups ( 12.501.08 minutes vs. 10.501.58 minutes , 10.401.26 minutes ; 15.000.94 minutes vs. 13.001.63 minutes , 12.801.13 minutes , P < 0.05 or P < 0.01 ) , but there was no significant difference between the latter two groups .