Biomarkers of inflammation/immunity ( interleukin -6 and -18 , soluble intercellular adhesion molecule , E-selectin , monocyte chemoattractant protein-1 , osteopontin , fibrinogen , N-terminal prohormone brain natriuretic peptide , high-sensitive C-reactive protein ) and oxidative stress ( thiobarbituric acid reactive substances , nitrotyrosine ) were increased , and antioxidant capacity was ( glutathione/glutathione disulfide ) decreased in patients vs healthy controls ( p < 0.05 ) .