In the hierarchical model , the average effect of the deleterious versus beneficial gene , controlling for average flavonoid intake in the DNA repair pathway , and adjusted for the three other biologically relevant pathways ( oxidative stress , carcinogen metabolism , and one-carbon metabolism ) , resulted in a 27 % increase risk for breast cancer [ odds ratio = 1.27 ; 95 % confidence interval ( CI ) = 0.70 , 2.29 ] .