When the cervical biopsy , Papanicolaou smear , and HPV results were combined for the 6 month follow-up visit , 50 % of the 5-FU group ( 14 of 28 ) had a documented normal biopsy , normal Papanicolaou smear , and negative HPV test compared with 22 % in the observation group ( 6 of 27 ) ( relative risk , 2.25 ; 95 % confidence interval , 1.05-5 .09 ; P < .05 ) .