For patients with mixed episodes , when compared to olanzapine , asenapine treatment was associated with improvements noted in every domain , which did not reach statistical significance except for Vitality ( asenapine = 55.0 , olanzapine = 51.3 ; p = 0.014 ) and Role-Emotional ( asenapine = 44.8 , olanzapine = 40.3 ; p = 0.020 ) .