When considering `` on treatment '' factors , 1 log10 HCV RNA decline at week 4 ( 3.733 , 95 % CI : 1.676-12 .658 , P = 0.034 ) and achievement of RVR BOC ( 7.347 , 95 % CI : 2.156-25 .035 , P = 0.001 ) were significantly related with the SVR , although RVR BOC only ( 6.794 , 95 % CI : 1.596-21 .644 , P = 0.010 ) maintained significance at multivariate logistic regression analysis .