Spironolactone therapy was associated with improvements in diastolic filling profile ( peak E wave velocity -4 15 vs. 9 10 ms , P = 0.001 ; E/A ratio -0.1 0.3 vs. 0.2 0.2 , P < 0.001 ) and cIB values ( -21.2 4.5 dB vs. -18.0 5.2 dB , P = 0.026 ; cIB -5.1 6.8 vs. -1.3 5.2 , P = 0.030 ) .