Pioglitazone induced a decrease in hemoglobin A1c ( 8.3 % 2.5 % vs 9.5 % 3.2 % , P = .068 ) and serum triglycerides ( 1.58 0.89 vs 2.03 0.70 mmol/L , P = .069 ) and an increase in HDL cholesterol ( 1.39 0.22 vs 1.14 0.22 mmol/L , P = .018 ) .