By multivariable analysis , the presence of moderate/severe target lesion calcification was an independent predictor of 1-year definite stent thrombosis ( hazard ratio [ HR ] : 1.62 ; 95 % confidence interval [ CI ] : 1.14 to 2.30 ; p = 0.007 ) and ischemic TLR ( HR :1.44 ; 95 % CI : 1.17 to 1.78 ; p = 0.0007 ) .