Mean PRU remained significantly higher in the combined prasugrel groups versus the ticagrelor group ( least-squares mean difference : 46 [ 95 % confidence interval 25 to 67 ] ) and did not meet the primary noninferiority endpoint ( upper limit of the confidence interval 45 ) , although PRU in the prasugrel cohort was lower at 7 days than at 24 or 48 h. Accordingly , rates of high on-treatment platelet reactivity were higher at 24 and 48 h in both prasugrel groups .