Between March 2005 and November 2008 , 248 patients with T3-4N0-2M0 rectal cancer were prospectively randomized to either long-course preoperative CRT ( 50.4 Gy in 28 fractions , per oral tegafur-uracil and L-leucovorin ) alone or the same CRT schedule plus a brachytherapy boost ( 10 Gy in 2 fractions ) .