Addition of fluorouracil led to increased rates of grade 3-4 neutropenia ( 354 [ 345 % ] of 1025 patients on FEC-P vs 250 [ 242 % ] of 1032 patients on EC-P ; p < 00001 ) , fever ( nine [ 09 % ] vs two [ 02 % ] ) , nausea ( 47 [ 46 % ] vs 28 [ 27 % ] ) , and vomiting ( 32 [ 31 % ] vs 15 [ 14 % ] ) .