Patients receiving sofosbuvir + ribavirin + interferon ( NEUTRINO ) had a decrease in utilities during treatment ( SF-6D : from 0.72 to 0.62 , EQ-5D : 0.79 to 0.65 ; P < 0.0001 ) similar to that observed in patients receiving pegylated interferon + ribavirin for 24 weeks in FISSION ( 0.72 to 0.62 and 0.77 to 0.65 , respectively , P < 0.0001 ) .