Trough FEV1 responses were significantly greater for tiotropium 5g ( p < 0.00001 ) and 1.25 g ( p = 0.0134 ) versus placebo , but not for 2.5 g ( p = 0.0975 ) , while FEV1 area under the curve ( 0-3h ) responses were significant for all doses ( p = 0.00001-0 .0398 ) .