At 65 weeks , 28 patients ( 44 % ) who had received combination therapy , 19 ( 29 % ) who had received methotrexate alone , and 15 ( 23 % ) who had received placebo were in remission ( P = 0.10 for combination therapy vs. methotrexate alone ; P = 0.02 for combination therapy vs. placebo ; P = 0.55 for methotrexate alone vs. placebo ) .