Compared with patients on E/C/F / TDF , patients on E/C/F / TAF had smaller reductions in estimated creatinine clearance ( -5.5 vs. -10.1 mL/min , P = 0.041 ) , significantly less renal tubular proteinuria , and smaller changes in bone mineral density for hip ( -0.62 % vs. -2.39 % , P < 0.001 ) and spine ( -1.00 % vs. -3.37 % , P < 0.001 ) .