The mean cumulative number of new T1 Gd + lesions at weeks 12-24 was significantly lower in the ponesimod 10 mg ( 3.5 ; rate ratio ( RR ) 0.57 ; p = 0.0318 ) , 20 mg ( 1.1 ; RR 0.17 ; p < 0.0001 ) and 40 mg ( 1.4 ; RR 0.23 ; p < 0.0001 ) groups compared with placebo ( 6.2 ) .