The targeted temperature management 33 ( TTM33 ) group had a hemodynamic profile with lower heart rate ( -7.0 min ( -1 ) [ 95 % confidence limit , -8.7 , -5.1 ] ; p ( group ) < 0.0001 ) , similar mean arterial pressure ( -1.1 mm Hg [ 95 % confidence limit , -2.3 , 0.2 ] ; p ( group ) = 0.10 ) , and increased lactate ( 0.6 mmol/L [ 95 % confidence limit , 0.3 , 0.8 ] ; p ( group ) < 0.0001 ) compared with the targeted temperature management 36 ( TTM36 ) group .