The improvements on day 1 were 4.0 % ( 90 % confidence limits , 3.3 ) and 4.0 % 2.9 % for both CAF doses , respectively ( P < 0.05 ) , whereas improvements on day 2 were 5.0 % 3.6 % and 5.1 % 2.8 % for CAF3 and CAF4 .5 , respectively , compared with those for PLA .