LRTI ( RR , 5.31 ; 95 % CI , 2.71-10 .41 ) , eczema ( RR , 2.77 ; 95 % CI , 1.78-4 .31 ) , aeroallergen sensitization ( RR , 5.60 ; 95 % CI , 2.86-10 .9 ) , and food sensitization ( RR , 2.77 ; 95 % CI , 1.56-4 .94 ) increased the risk of intermediate-onset wheeze , whereas dog exposure at baseline ( RR , 0.52 ; 95 % CI , 0.32-0 .84 ) and first-born status ( RR , 0.49 ; 95 % CI , 0.32-0 .76 ) were protective .