The addition of cediranib increased response rate ( [ RR ] 52 % versus 34 % , p = 0.001 ) but did not significantly improve PFS ( HR 0.91 , 95 % CI 0.71-1 .18 , p = 0.49 ) or OS ( HR 0.94 , 95 % CI 0.69-1 .30 , p = 0.72 ) .