Among patients who had in-trial IAT , CRT-D was associated with a significant 57 % reduction in the risk of HF/death compared with ICD-only therapy ( HR : 0.43 , p = 0.047 ) , similar to the effect of the device among patients who did not have IAT ( HR : 0.47 , p < 0.001 ; p for interaction = 0.85 ) .