In the high-dose group , the area under the curve of estradiol concentrations adjusted by creatinine are ( 7160.28 2305.52 ) , ( 6700.26 2066.67 ) ; ( 6676.24 2573.89 ) ; the area under the curve of pregnanediol concentrations corrected by creatinine are ( 51.93 18.80 ) , ( 44.55 14.62 ) and ( 46.49 22.44 ) .