Specifically , LS individuals responded to PS treatment with a reduction in TC ( -0.40 0.07 mmol/L ; P < 0.0001 ) and LDL cholesterol ( -0.29 0.05 mmol/L ; P = 0.0002 ) , whereas HS individuals failed to show cholesterol lowering ( TC : -0.09 0.09 mmol/L ; P = 0.2843 ; LDL cholesterol : -0.05 0.07 mmol/L ; P = 0.4917 ) .