At the 4 th week after GnRH-a therapy , KMI and hot flash/sweating score results were as follows : Control group > Kuntai group > Tibolone group ( P < 0.05 ) ; at the 8 th and 12 th week after GnRH-a therapy , KMI and hot flash/sweating score in Control group were significantly higher than the other two groups ( P < 0.05 ) , and no significant difference was identified between Kuntai and Tibolone group ( P > 0.05 ) .