Urocortin-2 produced greater falls in systolic blood pressure compared to placebo ( 16 5.8 mm Hg , p < 0.001 ) with nonsignificant increases in heart rate ( 5.7 3.8 beats/min , p = 0.07 ) and increased cardiac output ( 2.1 0.4 l/min vs. -0.1 0.4 l/min , p < 0.001 ) associated with a 47 % reduction in calculated total peripheral resistance ( p = 0.015 ) .