Baseline MR-proADM concentrations predicted major CHD events ( non-fatal myocardial infarction or CHD death ; hazard ratio ( HR ) 1.52 , 1.26-1 .84 for Q4-Q1 ) , CHD death ( HR 2.21 , 1.67-2 .92 ) , heart failure ( HR 2.30 , 1.78-2 .97 ) and all-cause mortality ( HR 1.82 , 1.49-2 .23 ) .