The most common grade 3 or worse adverse events were increased lipase ( 137 [ 17 % ] of 784 patients in the orteronel plus prednisone group vs 14 [ 2 % ] of 770 patients in the placebo plus prednisone group ) , increased amylase ( 77 [ 10 % ] vs nine [ 1 % ] ) , fatigue ( 50 [ 6 % ] vs 14 [ 2 % ] ) , and pulmonary embolism ( 40 [ 5 % ] vs 27 [ 4 % ] ) .