Before adjuvant CHT 21.1 % ( 416 out of 1972 ) and 20.6 % ( 247 out of 1198 ) of the patients were CTC-positive , while after CHT 22.5 % ( 359 out of 1598 ) and 16.6 % ( 177 out of 1066 ) of the patients were CTC-positive using CSS or MICC , respectively .