This multicenter , double - blind , randomized clinical trial consisted of 2 run - in and 3 treatment cycles ( 84 days ) with daily symptom charting ; 187 women with symptoms of PMDD were randomized to either placebo group ( n = 94 ) or YAZ group ( n = 93 ) , and assessed with daily record of severity of problems scale ( DRSP ) and clinical global impressions scale ( CGI ) before , during and after the treatments .