In fact , the Factsheet , HPE , and HPE + MI participants all experienced significant reductions in secondary conditions , F ( 2.85 , 489 ) = 7.808 , p < .001 , HRQoL symptom days , F ( 2.7 , 495 ) = 4.795 , p = .004 ; and significant improvements in healthy lifestyle behaviors , F ( 2.6 , 495 ) = 3.66 , p = .017 over the 6-month study period .