Double-dummy , double-blind study ( NCT01001832 ) ; 118 adults with 10 swollen joints , 12 tender joints and C-reactive protein ( CRP ) 0.8 mg/dL randomized 1:1 to SC abatacept ( 125 mg weekly ) with IV loading ( 10 mg/kg on Day 1 ) , or IV abatacept ( 10 mg/kg monthly ) for 169 days , both also receiving MTX ( 6-8 mg/week ) .