Allocation to the insulin glargine group reduced the incidence of the primary microvascular composite outcome of kidney and eye disease in participants whose baseline HbA1c level was 6.4 % ( 46.4 mmol/mol ; HR 0.90 [ 95 % CI 0.81 , 0.99 ] ) but not in participants with a lower baseline HbA1c ( HR 1.07 [ 95 % CI 0.95 , 1.20 ] ; p value for interaction 0.031 ) .