At 10 years , cumulative incidence of local relapse was 224 % ( 95 % CI 171-276 ) with radiotherapy alone , 118 % ( 78-158 ) with neoadjuvant radiotherapy and chemotherapy , 145 % ( 101-189 ) with radiotherapy and adjuvant chemotherapy and 117 % ( 77-156 ) with both adjuvant and neoadjuvant chemotherapy ( p = 00017 ) .