The multivariate analyses using preoperative factors showed that clinical stage T3 [ vs. cT1-2 ; hazard ratio ( HR ) 3.60 , p = 0.0007 ] and serum albumin ( Alb ) < 4.0 g/dl ( vs. 4.0 g/dl ; HR 2.29 , p = 0.0005 ) were associated with a poor prognosis .