There was a statistical significant ( P < 0.05 ) reduction of proBNP and NYHA class in patients with AVDopt compared to AVDfab ( proBNP : 196.4 144.7 pg/mL vs. 269.4 235.8 pg/mL ; NYHA class : 1.7 0.5 vs. 2.3 0.6 ) .