The IVA versus - blockers treatment was associated with a significant improvement of physical functioning ( p < 0.001 vs. p < 0.01 ) , physical role functioning ( p < 0.001 vs. p < 0.01 ) , emotional role functioning ( p < 0.01 vs. p < 0.85 ) , and mental health scales ( p < 0.001 vs. p < 0.01 ) .