In the ripasudil-timolol study , the mean IOP reductions from baseline in the ripasudil and placebo groups were -2.4 and -1.5 mm Hg at 9 am for a difference of 0.9 mm Hg ( 95 % CI , 0.4-1 .3 mm Hg ; P < .001 ) and -2.9 and -1.3 mm Hg at 11 am for a difference of 1.6 mm Hg ( 95 % CI , 1.1-2 .1 mm Hg ; P < .001 ) , respectively .