Plasma S100A12 and sRAGE , biomarkers of inflammation and nutritional status , and comorbidities were investigated in 200 CKD Stage 5 patients [ median age of 56 years , 62 % men and median glomerular filtration rate ( GFR ) of 6.2 mL/min/1 .73 m ( 2 ) ] in conjunction with initiation of dialysis therapy .