The respective changes in HbA1c were -0.77 % ( -8.4 mmol/mol ) and +0.01 % ( +0.1 mmol/mol ) ( difference -0.74 % [ -8.1 mmol/mol ] ) ( [ 95 % CI -1.08 % , -0.41 % ] [ -11.8 , -4.5 mmol/mol ] ; p < 0.001 ) ; respective changes in insulin dose were -29 U/day and +5 U/day ( difference -33 U/day [ 95 % CI -41 , -25 U/day ] ; p < 0.001 ) .