Ecchymosis decreased significantly in both upper and lower eyelids on the first , third , and seventh days in the remifentanil group ( P ( 1upper ) = 0.000 , P ( 3upper ) = 0.000 , P ( 3upper ) = 0.002 , P ( 3lower ) = 0.002 , P ( 7upper ) = 0.049 , and P ( 7lower ) = 0.038 ) .