The ( C ) ce ( s ) haplotype , mainly found in black individuals , contains two altered genes : a hybrid RHD-CE-D ( s ) gene segregated with a ce ( s ) allele of RHCE with two single nucleotide polymorphisms , c. 733C > G ( p.Leu245Val ) in exon 5 and c. 1006G > T ( Gly336Cys ) in exon 7 .