There was no difference in the rate of change of cognitive test scores between the insulin glargine and standard care groups ( for the MMSE 0.0046 , 95 % CI -0.0132 to 0.0224 , p = 0.39 ; and for the DSS -0.0362 , -0.2180 to 0.1455 , p = 0.34 ) or between the omega-3 fatty acid and placebo groups ( for the MMSE 0.0013 , 95 % CI -0.0165 to 0.0191 , p = 0.21 ; and for the DSS -0.0605 , -0.2422 to 0.1212 , p = 0.72 ) .