After adjustment for established risk factors of bleeding including the gain of function CYP2C19 * 17 allele , age , female gender , renal function , the multivariable logistic regression model demonstrated that ADP inhibition > 92.5 % ( OR 2.247 , 95 % CI 1.082-4 .665 , P = 0.03 ) , carriage of rs1045642 ( OR 2.943 , 95 % CI 1.195-7 .247 , P = 0.019 ) and rs7779562 ( OR 0.453 , 95 % CI 0.219-0 .936 , P = 0.032 ) were independent predictors of BARC 3 bleedings .