Combined unique active lesions were lower in patients treated with subcutaneous IFN -1 a versus placebo ( mean ( SD ) lesions per patient per scan : three times a week 0.6 ( 1.15 ) ; once a week 1.23 ( 4.26 ) ; placebo 2.70 ( 5.23 ) ; reduction versus placebo : three times a week 81 % ; once a week 63 % ; p < 0.001 ) and with three times a week versus once a week ( 48 % reduction ; p = 0.002 ) .