There was no statistically significant improvement in risk factor control between the fixed dose combination and usual care groups over 12 months : the difference in systolic blood pressure was -2.2 mm Hg ( -4.5 v -2.3 , 95 % confidence interval -5.6 to 1.2 , P = 0.21 ) , in diastolic blood pressure -1.2 mm Hg ( -2.1 v -0.9 , -3.2 to 0.8 , P = 0.22 ) and in low density lipoprotein cholesterol -0.05 mmol/L ( -0.20 v -0.15 , -0.17 to 0.08 , P = 0.46 ) .