In medicine group , there were 8 males and 10 females aged from 57 to 70 years old with an average of ( 63.516.61 ) the courses of diseases ranged from 3 to 5 months with an average of ( 4.821.43 ) , celecoxib with eperisone hydrochloride were orally taken , 4 days for a period treatment , totally 9 courses .