At week 8 , the fixed-dose combination 20 and 320 mg/day group had significantly greater reductions in diastolic blood pressure from baseline than both nebivolol 40 mg/day ( least-squares mean difference -12 mm Hg , 95 % CI -23 to -01 ; p = 0030 ) and valsartan 320 mg/day ( -44 mm Hg , -54 to -33 ; p < 00001 ) ; all other comparisons were also significant , favouring the fixed-dose combinations ( all p < 00001 ) .