The objective of this substudy of the Aortic Stenosis Progression Observation : Measuring Effects of Rosuvastatin ( ASTRONOMER ) trial was to examine the relationship between total ( ie , carboxylated [ active ] form + uncarboxylated [ inactive ] form ) circulating desphosphorylated matrix - carboxyglutamate protein ( dpMGP ) level and the progression rate of aortic stenosis ( AS ) .