Worse diuretic response was independently associated both with less relief of dyspnoea , measured with a visual analogue scale ( VAS ) at day 5 ( primary endpoint ; P = 0.0002 ) , and with a higher risk of cardiovascular death or rehospitalization for heart failure or renal failure through day 60 ( secondary endpoint , P < 0.0001 ) , but not with increased 180-day cardiovascular mortality ( P = 0.507 ) .