Similarly , 12-mo changes in dietary measures such as vegetable ( = 0.009 , P = 0.048 ) , protein ( = 0.04 , P = 0.001 ) , and total caloric ( = 0.05 , P = 0.01 ) intake were positively associated with changes in LUMA DNA methylation , as was intake of fruit positively associated with changes in LINE-1 DNA methylation ( = 0.004 , P = 0.02 ) .