Subjects ( n = 22 ) on continuous subcutaneous insulin infusion ( five females , 17 males ; median [ range ] age , 15 [ range , 14-20 ] years ; median [ range ] diabetes duration , 7 [ 2-14 ] years ; median [ range ] glycated hemoglobin , 8.0 % [ 6.7-10 .4 % ] ) exercised until the PLGM system suspended insulin delivery or until the reference blood glucose value ( HemoCue ( ) ; HemoCue GmbH , Groostheim , Germany ) reached the predictive suspension threshold setting .