Compared with the control arm , the HR for CRC was 2.5 ( 95 % CI 0.8 to 7.8 ) in individuals with large serrated polyps , 2.0 ( 95 % CI 1.3 to 2.9 ) in individuals with advanced adenomas and 0.6 ( 95 % CI 0.4 to 1.1 ) in individuals with non-advanced adenomas .