The acute physiology and chronic health evaluation II ( APACHEII ) score , sequential organ failure assessment ( SOFA ) , arterial oxygenation index ( PaO2/FiO2 ) , central venous oxygen saturation ( ScvO2 ) , arterial blood lactate ( Lac ) , C-reactive protein ( CRP ) levels of two groups were compared before treatment and 48 hours after treatment , and 21-day mortality rate was finally compared .