Compared with placebo , mean daily off-time was significantly reduced in the combined tozadenant 120 mg twice-daily and 180 mg twice-daily group ( -11 h , 95 % CI -18 to -05 ; p = 00006 ) , the tozadenant 120 mg twice-daily group ( -11 h , -18 to -04 ; p = 0.0039 ) , and the tozadenant 180 mg twice-daily group ( -12 h , -19 to -04 ; p = 00039 ) .