Treatment-emergent adverse events occurred in 5 % of duloxetine-treated patients and twice the rate than with placebo including constipation ( 9 % vs. 4 % , p = 0.06 ) , dry mouth ( 7 % vs. 1 % , p = 0.02 ) , and somnolence ( 6 % vs. 2 % , p = 0.14 ) .