After 2 weeks , significantly more subjects receiving esomeprazole 20mg ( 32.3 % [ 26.1 % -38.5 % ] and 26.3 % [ 18.9 % -33.6 % ] in trials 1 and 2 , respectively ) had resolution of nighttime heartburn symptoms compared to placebo ( 5.4 % [ 2.4 % -8.4 % ] and 4.8 % [ 1.1 % -8.5 % ] , respectively ; p < 0.0001 for both trials ) .