The TSP-1 rs1478604 A SNP was associated significantly with an increased risk of corneal allograft rejection ( odds ratio [ OR ] , 1.58 ; 95 % confidence interval [ CI ] , 1.02-2 .45 ; P = 0.04 ) and there was a trend toward the rs1478604 , rs2228261 , rs2228262 ACA haplotype increasing risk of rejection .