In ketoconazole study , eight patients were randomized ( 1:1 ) to sequence of a cycle of trabectedin ( 0.58 mg/m ( 2 ) , 3 h , i.v. ) coadministered with ketoconazole ( 200 mg , twice-daily , 15-doses ) , and a cycle of trabectedin monotherapy ( 1.3 mg/m ( 2 ) , 3 h , i.v. ) .