After the 3-month study period , patients in the treatment group showed significantly improved left ventricular end-diastolic diameter ( P = 0.02 ) , left ventricular end-systolic diameter ( P = 0.035 ) , left ventricular ejection fraction ( P = 0.05 ) , and left atrial diameter ( P = 0.02 ) values , and their serum N-terminal prohormone of brain natriuretic peptide ( P = 0.01 ) and high-sensitive C-reactive protein ( P = 0.04 ) concentrations were significantly improved compared with the control group .