Forty-four patients [ 35 females , age 54.3 years , disease duration 84.3 months , simplified disease activity index ( SDAI ) 36.5 , CRP 24.9 mg/l , ESR 53 mm/h , MMP-3 284 pg/ml , RF 172.6 IU/ml , neutrophil count 4842 per l , lymphocyte count 1410 per l ] were treated with tofacitinib .