Median ( range ) therapeutic doses by age group were as follows : infants ( n = 3 ) , 180 IU kg ( -1 ) ( 146-181 IU kg ( -1 ) ) ; children ( n = 7 ) , 125 IU kg ( -1 ) ( 101-175 IU kg ( -1 ) ) ; and adolescents ( n = 8 ) , 100 IU kg ( -1 ) ( 91-163 IU kg ( -1 ) ) .