Change scores for COT ( P < 0.001 ) , PWT ( P < 0.001 ) , 6-minute walk distance ( P = 0.028 ) , daily average cadence ( P = 0.011 ) , time to minimum calf muscle StO2 during exercise ( P = 0.025 ) , large-artery elasticity index ( LAEI ) ( P = 0.012 ) , and high-sensitivity C-reactive protein ( hsCRP ) ( P = 0.041 ) were significantly different among the 3 groups .