Significant EET improvements were observed with both UMEC/VI doses versus placebo at Week 12 in Study 418 ( UMEC/VI 125/25 mcg : 65.8 s ; p = 0.005 ; UMEC/VI 62.5 / 25 mcg : 69.4 s ; p = 0.003 ) , but not in Study 417 , where a placebo effect was evident .