AZD6280 induced dose-dependent smaller-than-lorazepam effects on saccadic peak velocity ( SPV ) ( AZD6280 , 10 mg vs. AZD6280 , 40 mg vs. lorazepam [ deg/s ] : -22.6 vs. -50.0 vs. -62.9 , P < 0.001 ) , whereas the impacts on adaptive-tracking , body-sway , smooth-pursuit , and the one-card-learning tests were significant but much smaller than lorazepam .