Most common adverse events occurring with E + T versus E + P were rash ( 33.1 % v 37.3 % , respectively ) , diarrhea ( 34.6 % v 41.0 % ) , asthenia or fatigue ( 43.5 % v 38.1 % ) , and neutropenia ( grade 3 to 4 ; 8.5 % v 0.8 % ) .