In the meta-analysis , 16/45 ( 36 % ) macroadenomas were cured using combined criteria in the pretreatment group vs 8/45 ( 18 % ) in the direct surgery group after 6-12 months ( P = 0.06 ) , and 15/41 ( 37 % ) vs 8/42 ( 19 % ) , respectively , in the long-term ( P = 0.08 ) .