Compared to placebo , there was a significantly greater weight loss with topiramate in all analyses : 9.5 kg ( SE 1.17 ) in the complete case analysis ( N = 86 ) , 6.8 kg ( SE 0.66 ) using LOCF ( N = 561 ) , 6.4 kg ( SE 0.90 ) using MI ( N = 561 ) and 1.5 kg ( SE 0.28 ) using BOCF ( N = 561 ) .