No significant improvements in PFS were observed in the trabectedin arms as compared to the doxorubicin arm ( T24h versus doxorubicin : hazard ratio ( HR ) 1.13 , 95 % confidence interval ( CI ) 0.67-1 .90 , P = .675 ; T3h versus doxorubicin : HR 1.50 , 95 % CI 0.91-2 .48 , P = .944 ) .