The relative effect of apixaban compared with aspirin was similar in men and women for both ischemic stroke ( women , 3.99 % versus 1.55 % ; hazard ratio , 0.39 ; 95 % confidence interval , 0.23-0 .64 ; men , 2.28 % versus 0.82 % ; hazard ratio , 0.36 ; 95 % confidence interval , 0.19-0 .63 ; Pint = 0.84 ) and major bleeding ( women , 1.29 % versus 1.15 % ; hazard ratio , 1.15 ; 95 % confidence interval , 0.59-2 .23 ; men , 1.36 % versus 1.22 % ; hazard ratio , 1.13 ; 95 % confidence interval , 0.64-2 .02 ; Pint = 0.96 ) .