At the end of treatment , the HBV DNA negative rate , HBeAg seroconversion rate and HBsAg loss rate in the observational group were 51.9 % , 48.8 % and 1.9 % , respectively , which were all lower than control group ( 67.3 % , 66.7 % and 7.3 % , respectivley ) ( all P < 0.05 ) .