In this open prospective study , 167 women with hirsutism due to polycystic ovary syndrome ( PCOS ) were randomly assigned to the following treatment protocols : Group A ( n = 72 ) : spironolactone 100 mg-norgestimate 250 mcg-ethinyl estradiol 35 microg ; Group B ( n = 70 ) : cyproterone acetate 12 mg-ethinyl estradiol 35 microg ; Group C ( n = 25 ) : norgestimate 250 microg-ethinyl estradiol 35 microg .