Patients were grouped into 3 categories : a fatigue score 0 to 1 ( n = 535 ) , fatigue score 2 ( n = 1,632 ) , and fatigue score 3 to 4 ( n = 1,663 ) ; and a dyspnea score of 1 ( n = 292 ) , dyspnea score of 2 ( n = 1,695 ) , and dyspnea score of 3 to 4 ( n = 1,843 ) .