Both prednisolone and M. indicus pranii , each as compared with placebo , were associated with a significant increase in the incidence of cancer ( 1.8 % vs. 0.6 % ; hazard ratio , 3.27 ; 95 % CI , 1.07 to 10.03 ; P = 0.03 , and 1.8 % vs. 0.5 % ; hazard ratio , 3.69 ; 95 % CI , 1.03 to 13.24 ; P = 0.03 , respectively ) , owing mainly to an increase in HIV-associated cancer .