15 male Crl : CD ( ) R ( SD ) Br rats ( Charles River Italia , Como , Italy ) randomized to three treatment groups : ( 1 ) animals with occluded bile ducts , ( 2 ) animals with occluded renal vessels and ( 3 ) control animals , each received 0.25 mmol kg ( -1 ) of bodyweight of gadobenate dimeglumine ( MultiHance ( ) ; Bracco Imaging SpA , Milan , Italy ) .