In controls subjects , right atrial pressure , pulmonary arterial pressure , and pulmonary capillary wedge pressure increased similarly with saline and exercise , whereas in HFpEF subjects , exercise led to 2-fold greater increases in right atrial pressure ( 104 versus 63 mm Hg ; P = 0.02 ) , pulmonary arterial pressure ( 228 versus 114 mm Hg ; P = 0.0001 ) , and pulmonary capillary wedge pressure ( 185 versus 104 mm Hg ; P < 0.0001 ) compared with saline .