The most common grade 3 and 4 toxicities were alanine aminotransferase or aspartate aminotransferase increases ( one [ 4 % ] in the interruption group vs three [ 14 % ] in the continuation group ) , neutropenia ( two [ 8 % ] vs two [ 10 % ] ) , and intestinal occlusion ( one [ 4 % ] vs one [ 5 % ] ) .