Patient characteristics that appeared to negatively influence OS included more advanced age ( hazard ratio [ HR ] 1.560 for 75 vs < 70 years ; p = 0.0010 ) , poorer performance status at baseline ( HR 0.771 for 0 or 1 vs 2 ; p = 0.0321 ) , poor cytogenetics ( HR 0.699 for intermediate vs poor ; p = 0.0010 ) , higher bone marrow blast counts ( HR 1.355 for > 50 % vs 50 % ; p = 0.0045 ) , low baseline platelet counts ( HR 0.775 for each additional 100 109/L ; p = 0.0015 ) , and high white blood cell counts ( HR 1.256 for each additional 25 109/L ; p = 0.0151 ) .