The change in NT-proBNP was poorly correlated with change in SBP ( LCZ696 , r = 0.17 , P = 0.06 ; valsartan , r = 0.05 , P = 0.58 ) After adjustment for change in SBP , the ratio of change in NT-proBNP at 12weeks for LCZ696 vs. valsartan was 0.76 ( 95 % CI 0.63-0 .93 , P = 0.008 ) , and similar to the ratio not adjusting for SBP ( 0.76 , 95 % CI 0.63-0 .92 , P = 0.006 ) ; P for interaction was 0.38 ) .