Several randomized controlled clinical trials of PTA balloons coated with different formulations of paclitaxel have been conducted in Europe ( N Engl J Med 2008 ; 358:689 -699 ) ( Circulation 2008 ; 118:1358 -1365 ) ( Circ Cardiovasc Interv 2012 ; 5:831 -840 ) ( JACC Cardiovas Interv 2014 ; 7:10 -19 ) and demonstrated more durable efficacy than PTA with comparable safety .