In time-varying Cox analyses , women had a 40 % lower rate of ischaemic CV events ( 95 % CI 21 % to 54 % ) , in particular , more than 50 % lower rate of stroke and coronary artery bypass grafting , and a 31 % lower all-cause mortality ( 95 % CI 1 % to 51 % ) , independent of active study treatment , age and hypertension , as well as time-varying valve area , low systolic function and abnormal LV geometry .