Dapagliflozin produced sustained reductions in weight and systolic blood pressure , whereas glipizide increased weight and systolic blood pressure , giving 104-week dapagliflozin versus glipizide differences of -5.1 kg ( 95 % CI : -5.7 , -4.4 ) and -3.9 mmHg ( 95 % CI : -6.1 , -1.7 ) , respectively .