In subjects dosed with 4 and 16 mg/kg sugammadex , geometric mean ratios ( treated vs. placebo ) for AUC2-60min were 1.085 ( 95 % confidence interval , 0.888 - 1.325 ) and 1.019 ( 0.868 - 1.195 ) , respectively , for APTT , and 1.047 ( 0.904 - 1.213 ) and 1.096 ( 0.953 - 1.261 ) , respectively , for PT ( INR ) .