However , significant differences in IMR ( 23.510.2 U vs. 34.221.7 U , p = 0.018 ) , % E2 % 88 % 86EF ( follow-up EF - baseline EF ; 3.334.6 % vs. 0.731.9 % , p = 0.005 ) , and % E2 % 88 % 86WMSI ( follow-up WMSI - baseline WMSI ; -0.1210.16 vs. -0.0040.07 , p = 0.001 ) were observed between the two groups .