The least squares mean reduction from baseline in serum potassium level at week 4 or time of first dose titration in patients with mild hyperkalemia was 0.35 ( 95 % CI , 0.22-0 .48 ) mEq/L for the 4.2 g twice daily starting-dose group , 0.51 ( 95 % CI , 0.38-0 .64 ) mEq/L for the 8.4 g twice daily starting-dose group , and 0.55 ( 95 % CI , 0.42-0 .68 ) mEq/L for the 12.6 g twice daily starting-dose group .