Adjusted Cox models showed that only elevated serum lactate dehydrogenase ( HR , 2.04 ; p < 0.001 ) , males ( HR , 1.36 ; p = 0.04 ) , performance status of 1 ( HR , 1.25 ; p = 0.02 ) , and weight loss greater than or equal to 5 % ( 1.53 , p = 0.01 ) were independently associated with OS .