The central apnea-hypopnea index was elevated following administration of indomethacin ( 89.2 43.7 to 112.5 32.9 events/h ; mean standard deviation ; P < 0.05 ) and was reduced following IV acetazolamide ( 89.2 43.7 to 47.1 48.1 events/h ; P < 0.001 ) .