A multinational , randomized , open-label trial that compared insulin lispro low mixture ( LM25 ; n = 236 ) twice daily with a basal-prandial regimen of insulin glargine once daily and insulin lispro once daily ( IGL ; n = 240 ) over 24 weeks in patients with HbA1c 7.5-10 .5 % and fasting plasma glucose 6.7 mmol/l .