Patients randomized to bupropion ( n = 109 ) and those randomized to placebo ( n = 116 ) experienced similar improvements in HRQOL during follow-up ( difference in change in EQ-5D index from baseline to 6 months = 0.02 , 95 % confidence interval [ CI ] = -0.04 , 0.08 ; from baseline to 12 months = 0.02 , 95 % CI = -0.04 , 0.08 ) .