Efficacy was not significantly different in the dose-escalation arm compared with the standard-dose arm ( OS : median 7.0 vs 8.4 months , respectively , hazard ratio ( HR ) , 1.26 , 95 % confidence interval ( CI ) : 0.88-1 .80 ; P = 0.2026 ; PFS : median 3.5 vs 4.5 months , respectively , HR , 1.09 , 95 % CI : 0.77-1 .54 ; P = 0.6298 ) .