To address this , 45 men and women ( age 40-75 years ) with stage I hypertension were randomized to receive either nebivolol ( NB ; forced titration to 10 mg OD ; n = 15 ; age 57.2 11.4 years ; body mass index [ BMI ] 30.8 5.8 kg/m ( 2 ) ) , lifestyle modification ( LM ; 5-10 % weight loss via calorie restriction and physical activity ; n = 15 ; age 52.7 8.5 years ; BMI 33.9 7.2 kg/m ( 2 ) ) or nebivolol plus lifestyle modification ( NBLM ; n = 15 ; age 58.9 9.4 years ; BMI 32.5 4.9 kg/m ( 2 ) ) for 12 weeks .