Ten-year cumulative incidence of distant metastasis and DFS were 10.5 % and 89.5 % for patients with TRG 4 ( complete regression ) , 29.3 % and 73.6 % for TRG 2 and 3 ( intermediate regression ) , and 39.6 % and 63 % for TRG 0 and 1 ( poor regression ) , respectively ( P = .005 and P = .008 , respectively ) .