Other end points included trough FEV1 at day 1 , FEV1 area under the curve from 30 minutes to 4 hours ( AUC30min-4h ) , peak FEV1 , inspiratory capacity and trough forced vital capacity ( FVC ) at day 1 and week 12 , and transition dyspnea index ( TDI ) focal score , COPD symptoms , and rescue medication use over 12 weeks .