The average predicted dose of the 142 patients who reached a stable dose was ( 3.6 0.9 ) mg/d , and the average effective dose was ( 3.7 1.3 ) mg/d , the average predicted dose being lower than the actual dose ( 0.1 1.2 ) mg/d , but the difference was not significant ( t = -1.202 , P > 0.05 ) .