Notably , one metabolite matching 2-hydroxybiphenyl was significantly associated with an increased risk of diabetes , whereas four metabolites matching PC ( 22:6 / 20:4 ) , ( 3S ) -7 - hydroxy-2 ' ,3 ' ,4 ' ,5 ' ,8 - pentamethoxyisoflavan , or tetrapeptides were significantly associated with decreased risk of diabetes .