We performed a genetic association cross-sectional study evaluating single nucleotide polymorphisms ( SNPs ) in 58 candidate genes and risk of FibroSURE-Acti Test determined advanced fibrosis ( F3/F4-F 4 advanced cases vs. F0-F3 mild controls ) and inflammation ( A2/A3-A 3 advanced cases vs. A0-A2 mild controls ) .