In all participants , pretreatment pain severity increased with every quartile increase in both the HMW : T-ADP ratio ( coefficient of variation [ CV ] 0.51 ; 95 % confidence interval [ CI ] : 0.08 , 0.93 ; p = 0.019 ) and resistin levels ( CV 0.58 ; 95 % CI : 0.21 , 0.96 ; p = 0.002 ) , but was not associated with quartile changes in leptin levels .