Trial 2 ( 24-month follow-up ) subjects are randomly assigned to a formulation containing 10mgL , 10mg MZ , 2mg Z plus 500mg vitamin C , 400IU vitamin E , 25mg zinc and 2mg copper ( Intervention A ; n = 75 ) or 10mgL and 2mg Z plus 500mg vitamin C , 400IU vitamin E , 25mg zinc and 2mg copper ( Intervention B ; n = 75 ) .