Age had no significant impact on OS ( 11.8 months , 12.3 months , 11.7 months , and 12.5 months , respectively ; p = .82 ) , PFS ( 3.5 months , 2.9 months , 3.8 months , and 4.0 months , respectively ; p = .42 ) , ORR ( 12.7 % , 12.5 % , 6.3 % , and 10.1 % , respectively ) , or CBR ( 20.2 % , 20.8 % , 20.4 % , and 21.5 % , respectively ) .