LS mean ( 95 % CI ) difference for etoricoxib vs. ibuprofen SPID6 , GLOBAL6 , and GLOBAL24 were 0.20 ( -1.16 , 1.57 ) ( p = 0.768 ) , 0.26 ( 0.07 , 0.45 ) ( p = 0.007 ) , and 0.36 ( 0.17 , 0.54 ) ( p < 0.001 ) , respectively .