Biomarkers of inflammation , immunity , oxidative stress , and cardiac signaling underlying growth and inflammation ( extracellular signal-related kinase 1/2 , p38 mitogen-activated protein kinase , mitogen-activated protein kinase kinases [ MEK ] 1/2 and 3/6 , c-Src ) , and apoptosis and survival ( c-Jun NH2-terminal kinases [ JNK ] , Bax/Bcl2 , Akt ) were assessed at 2 , 4 , 12 , 26 , and 52 weeks post-CTX .