ESZ SIGNIFICANTLY IMPROVED TOTAL SLEEP TIME ( MEAN INCREASE : ESZ , 95 min ; placebo , 9 min ) ( primary outcome ) and nearly all sleep measures as well as visual analog scale pain ( mean decrease : ESZ , 17 mm ; placebo , 2 mm ) ( primary pain outcome ) , and depression ( mean Hamilton Depression Rating Scale improvement ESZ , 3.8 ; placebo , 0.4 ) compared with placebo .