In addition , patients in the cisplatin plus gemcitabine group had significantly fewer events of grade 1-4 alopecia ( 12 [ 10 % ] vs 42 [ 36 % ] ) and peripheral neuropathy ( 27 [ 23 % ] vs 60 [ 51 % ] ) , but more grade 1-4 anorexia ( 33 [ 28 % ] vs 10 [ 8 % ] ) , constipation ( 29 [ 25 % ] vs 11 [ 9 % ] ) , hypomagnesaemia ( 27 [ 23 % ] vs five [ 4 % ] ) , and hypokalaemia ( 10 [ 8 % ] vs two [ 2 % ] ) .