Compared with controlled HTN , res-HTN had multivariate-adjusted association with higher risk of adverse outcomes { first occurrence of all-cause death , nonfatal myocardial infarction , or nonfatal stroke [ hazard ratio 1.27 , 95 % confidence interval ( CI ) 1.13-1 .43 ] , and individual outcomes of all-cause death ( hazard ratio 1.29 , 95 % CI 1.13-1 .48 ) , cardiovascular mortality ( hazard ratio 1.47 , 95 % CI 1.21-1 .78 ) , and nonfatal stroke ( hazard ratio 1.61 , 95 % CI 1.17-2 .22 ) , but not nonfatal myocardial infarction ( hazard ratio 0.98 , 95 % CI 0.72-1 .34 ) } .