In multivariate analysis , renal events were significantly associated with the LPV/r arm [ odds ratio ( OR ) 3.12 , 95 % confidence interval ( CI ) 1.21 , 8.05 ; P = 0.019 ] , baseline HIV-1 RNA ( OR 2.65 , 95 % CI 1.23 , 5.69 per 1 log10 copies/ml higher ; P = 0.013 ) and baseline creatinine clearance ( OR 0.83 , 95 % CI 0.70-0 .98 per 10 ml/min higher ; P = 0.030 ) .