When compared with the area under the curve ( AUC ) following NPH and glargine , detemir resulted in the lowest 6-14h AUC ( mean and range ) of IGFBP1 ( 1518 ( 1280-1800 ) ) vs 1621 ( 1367-1922 ) vs 1020 ( 860-1210 ) g/lh ) and GH ( 17.1 ( 14.1-20 .6 ) vs 15.4 ( 12.7-18 .6 ) vs 10.2 ( 8.5-12 .3 ) g/lh ) , but in the highest AUC of bioactive IGF ( 3.8 ( 3.5-4 .2 ) vs 3.7 ( 3.4-4 .0 ) vs 4.4 ( 4.1-4 .8 ) g/lh ) ( all P < 0.01 ) .