Compared with beclometasone-formoterol plus salbutamol as needed , beclometasone-formoterol for both maintenance and reliever treatment significantly increased the time to first exacerbation ( 209 days vs 134 days ) by 75 days , with a 36 % reduction in risk ( hazard ratio 064 [ 95 % CI 049 to 082 ] ; p = 00005 ) , and the estimated probability was 12 % and 18 % , respectively ( p = 00003 ) .