Although glucocorticoids are widely used in the treatment of patients with early rheumatoid arthritis , the best dosage of glucocorticoids with regards to efficacy and safety is not known.The aim of the study ` Comparison of the efficacy and safety of two starting dosages of prednisolone in early active rheumatoid arthritis ' ( CORRA ) is to compare two standard glucocorticoid starting dosages and the non-use of glucocorticoids in the treatment of patients with early active rheumatoid arthritis on the background of the established ` anchor ' therapy with methotrexate .