( 2 ) Compared with the healthy control group , BTLA expressions in the peripheral blood of AS patients decreased significantly ( P < 0.05 ) ; SOD , CAT , and TAOC values significantly decreased ( P < 0.01 , P < 0.05 ) ; ROS , RNS , and MDA values significantly increased ( P < 0.01 , P < 0.05 ) ; TNF - , IL-1 , ESR , and Hs-CRP values significantly increased ( P < 0.01 ) ; IL-4 and IL-10 values decreased significantly ( P < 0.01 , P < 0.05 ) .