Furthermore , the intake of opiates was significantly reduced in Group 1 ( day 1 , Group 1 : 42.1 vs. Group 2 : 73.5 , p = 0.010 ; day 2 , Group 1 : 27.7 vs. Group 2 : 52.5 , p = 0.012 ; day 3 , Group 1 : 23.9 vs. Group 2 : 53.5 , p = 0.002 ; day 4 , Group 1 : 15.7 vs. Group 2 : 48.3 , p = 0.003 ; day 5 , Group 1 13.3 vs. Group 2 : 49.9 , p = 0.001 ) .