The number of adverse events was 15 ( 8.3 % ) , 16 ( 8.9 % ) , 15 ( 8.3 % ) and 17 ( 9.4 % ) in Groups 1 , 2 , 3 and 4 , respectively , including dizziness , vomiting , diarrhea , nausea , skin rash , itchy skin , and malaise .