For the 73 participants not initiating ART ( median follow-up 225 weeks ) , of whom 48 reached the primary endpoint , higher baseline IL-6 , but not D-dimer , was independently associated with a shorter time to primary endpoint [ hazard ratio = 1.38 per additional pg/ml , 95 % confidence interval ( CI ) 1.09-1 .75 ; P = 0.007 ] .