Pioglitazone treatment resulted in a change in augmentation index of -4.7 % units ( 95 % confidence interval [ 95 % CI ] -7.9 , -1.5 ) ( P = 0.004 ) and in diastolic blood pressure of -3.0 mm Hg ( 95 % CI -5.7 , -0.2 ) ( P = 0.03 ) , but did not significantly change aortic PWV ( P = 0.33 ) or reactive hyperemia index ( P = 0.46 ) .