Compared with the control group at the same time period , WBC , N , CRP , and IL-6 all decreased in the treatment group at T1-T4 ( P < 0.05 ) , ESR decreased at T3-T4 ( P < 0.05 ) ; PT and TT decreased at T1-T3 ( P < 0.05 ) ; FIB and D-D decreased at T2-T4 ( P < 0.05 ) .