Rates of edema ( 26.1 % and 5.4 % for Asia and other regions , respectively ) , myalgia ( 42.3 % , 14.7 % ) , nail disorder ( 39.9 % , 15.1 % ) , febrile neutropenia ( 18.6 % , 7.1 % ) , upper respiratory tract infection ( 25.7 % , 10.2 % ) , decreased appetite ( 47.0 % , 19.1 % ) , and rash ( 44.3 % , 22.0 % ) were at least twice as high in Asia as in other regions .