Primary caregivers burden of care was significantly reduced in the intervention group ( -6.4 vs 1.5 ; p < 0.001 ; -9.4 vs 0.8 ; p < 0.001 ) , and their quality of life improved ( 9.2 vs -1.6 ; p = 0.01 ; 17.1 vs -5.3 ; p < 0.001 ) at post-treatment and three month-follow-up .