No significant differences in PaO2/FiO2 ( p = 0.37 ) , C reactive protein ( p = 0.23 ) , tumour necrosis factor - ( p = 0.58 ) , interleukin 6 ( IL-6 ; p = 0.64 ) , and IL-10 ( p = 0.61 ) levels at 48h of hospitalisation were found between simvastatin and placebo groups .