At 3-months , there was a non-significant difference in change score for FACIT-Sp between intervention and control groups ( 356 points [ 95 % CI -027 to 740 ] , p = 007 ) , a significant difference in QUAL-E ( 225 [ 001 to 449 ] , p = 005 ) and FAMCARE-P16 ( 379 [ 174 to 585 ] , p = 00003 ) , and no difference in ESAS ( -170 [ -526 to 187 ] , p = 033 ) or CARES-MIS ( -066 [ -225 to 094 ] , p = 040 ) .