The crude hazard ratio of TB during the trial and posttrial was 0.57 [ 95 % confidence intervals ( CI ) 0.33 , 0.99 ] and 0.82 ( 95 % CI 0.46 , 1.49 ) , and when restricted to TST-positive participants was 0.26 ( 95 % CI 0.08 , 0.80 ) and 0.40 ( 95 % CI 0.15 , 1.08 ) , respectively .