The percentage of subjects recording TTLUS was greater for those who received Aliva vs placebo at 30 min ( P = 0.027 ) , 2 h ( P = 0.000 ) , 24 h ( P = 0.000 ) , 48 h ( P = 0.000 ) , 72 h ( P = 0.000 ) , and 5 d ( P = 0.000 ) post dose .