After therapy , the NAA/Cr ratios and the itemized scores of cognitive scale compared with that of pre-therapy had significantly difference ( P < 0.05 ) in the dioscorea modified pill group ( MMSE ( 26.5 2.0 ) , CDR ( 0.14 0.23 ) ) vs ( MMSE ( 25.1 2.3 ) , CDR ( 0.5 ) ) .