After the treatment , the scores of MMSE and ADL were all improved among three groups , which was the most significant in the combined therapy group ( MMSE : 23.32 + / - 4.45 vs 21.23 + / - 4.13 , P < 0.05 ; 23.32 + / - 4.45 vs 20.41 + / - 4.01 , P < 0.01 ; ADL : 53.18 + / - 21.55 vs 51.92 + / - 20.42 , P < 0.05 ; 53.18 + / - 21.55 vs 49.42 + / - 19.43 , P < 0.01 ) .