Minor improvements in the benefits of amoxicillin were observed when an adjustments for adherence were made ( mean difference in symptom severity -0.08 , 95 % CI -0.17 to 0.01 , OR for new/worsening symptoms 0.81 , 95 % CI 0.66 to 0.98 ) as well as minor increases in harms ( OR for side effects 1.32 , 95 % CI 1.12 to 1.57 ) .