Immediately after pin removal , the mean difference in pain score ( and 95 % confidence interval [ CI ] ) between the acetaminophen group and the ibuprofen group was 0.10 ( -1.03 to 1.23 ) ; between the acetaminophen group and the placebo group , 0.35 ( -0.78 to 1.48 ) ; and between the ibuprofen group and the placebo group , 0.25 ( -0.88 to 1.38 ) .