To investigate effects of structured patient education intervention on knowledge , emergency management skills and psychological parameters in patients with previous episodes of anaphylaxis and caregivers of affected children 95 caregivers ( 11 male , 84 female , mean age 37years ) of affected children and 98 patients ( 32 male , 66 female , mean age 47.5 years ) were randomly assigned to an intervention ( IG ) or control group ( CG ) in a multicentre randomized controlled trial .