EQ-5D utility scores averaged 003 ( 95 % CI 001-005 ; p = 00002 ) better with levodopa than with levodopa-sparing therapy ; rates of dementia ( hazard ratio [ HR ] 081 , 95 % CI 061-108 , p = 014 ) , admissions to institutions ( 086 , 063-118 ; p = 04 ) , and death ( 085 , 069-106 , p = 017 ) were not significantly different , but the upper CIs precluded any substantial increase with levodopa compared with levodopa-sparing therapy .