The benefit of CRT-D in reducing the risk of HF/death was evaluated using multivariate Cox models incorporating the presence of , respectively , a history of IAT at baseline and time-dependent development of in-trial IAT during follow-up in 1,264 patients with LBBB enrolled in the MADIT-CRT ( Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy ) study .