After adjusting for other factors , odds of occurrence of AE of CTC grade3 were significantly increased with each unit decrease in baseline FACT-G score ( OR = 1.02 , 95 % CI 1.00-1 .03 , p = 0.030 ) , which was driven by physical well-being ( PWB ) ( OR = 1.09 , 95 % CI 1.04-1 .13 , p = 0.0002 ) and functional well-being subscales ( FWB ) ( OR = 1.04 , 95 % CI 1.00-1 .07 , p = 0.035 ) .