ACPA-positive patients receiving triple therapy had the greatest benefits : two-year mean Larsen score increases comprised 3.66 ( 95 % confidence interval ( CI ) 2.27 to 5.05 ) with triple therapy and 9.58 ( 95 % CI 6.76 to 12.39 ) with monotherapy ; OR for new erosions with triple therapy versus monotherapy was 0.32 ( 95 % CI 0.14 to 0.72 ; P = 0.003 ) .