The patients received standard medical therapy in the run-in phase ; in the treatment phase , patients with glycated hemoglobin of 7.5-9 .5 % were randomly assigned into four groups and underwent BM-MNC infusion along with HOT ( BM-MNC + HOT group ) , BM-MNC infusion ( BM-MNC group ) , HOT ( HOT group ) and standard medical therapy ( control group ) , respectively .