Sixty-three mildly hypercholesterolemic adults who were preselected as possessing either high endogenous cholesterol synthesis [ HS ; n = 24 ; L : C = 2.03 0.39 mol/mmol ( mean SD ) ] or low endogenous cholesterol synthesis ( LS ; n = 39 ; L : C = 0.99 0.28 mol/mmol ) on the basis of baseline L : C consumed 2 g PS/d or a placebo for 28 d with the use of a dual-center , single-blind , randomized crossover design .