Updating RHR with annual in-study reexaminations , time-varying RHR was highly associated with excess MCEs ( HR 1.1 per 10min ( -1 ) faster , 95 % CI : 1.1-1 .3 ) and cardiovascular mortality ( HR 1.4 per 10min ( -1 ) faster , 95 % CI : 1.2-1 .7 , both p0 .006 ) .