The primary objective was met : after a Hib-MenC-TT booster dose at 12 months of age the MenC rSBA geometric mean titres induced in infants primed with a single MenC-CRM dose were not inferior to those induced in participants primed with two MenC-CRM doses in infancy ( 660 ( 95 % confidence interval 498 to 876 ) v 295 ( 220 to 398 ) ) with a corresponding difference in the mean log10 MenC rSBA of 0.35 ( 0.17 to 0.53 ) that showed superiority of the single over the two dose schedule ) .