Compared with placebo , teriflunomide 14 mg reduced the risk of sustained accumulation of disability ( hazard ratio [ HR ] 0.68 [ 95 % CI 0.47-1 .00 ] ; log-rank p = 0.0442 ) ; however , teriflunomide 7 mg had no effect on sustained accumulation of disability ( HR 0.95 [ 0.68-1 .35 ] ; log-rank p = 0.7620 ) .