Compared with placebo , daglutril also significantly reduced office systolic BP ( -54 , 154 ; p = 0028 ) , but not diastolic ( -18 , 99 ; p = 0245 ) , pulse ( -31 , 106 ; p = 0210 ) , or mean ( -21 , 104 ; p = 0205 ) BP , and increased big endothelin serum concentration .