Mean global improvement as measured by the Clinical Global Impression of Change ( CGI-C ) was 1.9 1.1 ( i.e. much improved ) and 3.2 1.2 ( i.e. minimally improved ) in the NAB and PBO groups , respectively ( p = 0.05 ) Five out of 10 ( 50 % ) were much improved on NAB versus 1 out of 9 ( 11 % ) on PBO .