The LS mean estimates of the percent change from baseline for placebo ( -5.7 % ) was nominally smaller than 165 mg PGB-CR ( -15.0 % , p = 0.540 ) and 330 mg PGB-CR ( -31.5 % , p = 0.079 ) ; however , the median percent changes from baseline were not as well differentiated ( placebo , -35.4 % ; 165 mg PGB-CR , -38.0 % ; 330 mg PGB-CR -43.4 % ) .