OS did not improve with E + T versus E + P ( median OS , 8.5 v 7.8 months , respectively ; hazard ratio [ HR ] , 0.98 ; 95 % CI , 0.84 to 1.15 ; P = .81 ) , even though PFS increased ( median PFS , 3.6 v 1.9 months ; HR , 0.74 ; 95 % CI , 0.62 to 0.89 ; P < .001 ) .