Participants with 0 to 2 RFs in control during follow-up had a 2-fold higher risk of death ( hazard ratio : 2.0 ; 95 % confidence interval : 1.3 to 3.3 ; p = 0.0031 ) and a 1.7-fold higher risk of the composite endpoint ( hazard ratio : 1.7 ; 95 % confidence interval : 1.2 to 2.5 ; p = 0.0043 ) , compared with those with 6 RFs in control .