In a cross-study comparison with data at months 1 and 3 from the pharmacokinetic substudy of the A2307 trial , in which patients received cyclosporine , mean values for everolimus C0 , Cmax and AUC0-12 were similar to those in the ASSET trial but the everolimus dose needed to achieve similar exposure was 1.5 - to 2-fold higher with concomitant tacrolimus versus cyclosporine .