Geometric mean ratio ( 90 % CI ) for AUC0-48 and Cmax was 0.6 ( 0.5-0 .7 ) and 0.5 ( 0.4-0 .6 ) for RBT 150mg tiw compared with RBT 300mg and 0.4 ( 0.4-0 .4 ) and 0.5 ( 0.5-0 .6 ) for RBT 150mg tiw compared with 150mg daily .