A single centre , single-dose , open-label , healthy volunteer controlled trial was conducted in patients with renal impairment ( RI ) ( estimated glomerular filtration rate lower than 30 mL/min/1 .73 m ( 2 ) ) and age - , weight - and sex-matched healthy volunteers ( estimated glomerular filtration rate higher than 90 mL/min/1 .73 m ( 2 ) ) .