The effect of doubling the clopidogrel MD on relative change in RPA was neutralized by lansoprazole ( -53.648.4 % versus +0.853.7 % without and with lansoprazole , respectively , p = 0.02 ) whereas 10 mg of prasugrel MD dramatically reduced RPA irrespective of lansoprazole co-administration ( -81.8 % 24.8 % vs. -72.9 % 32.9 % without and with lansoprazole , respectively , p = NS ) .