HLA-DPB1 was independently associated with virological response [ adjusted odds ratio ( OR ) 1.8 , 95 % confidence interval ( CI ) :1.1 -3.0 , P = 0.025 ] , and with an undetectable HBV DNA ( adjusted OR 2.4 95 % CI : 1.2-4 .7 , P = 0.015 ) when adjusted for HBeAg status and other known response modifiers .