The MTFC-A group showed a non-significant improvement in CGAS outcome in both the randomised cohort ( n = 34 , adjusted mean difference 1.3 , 95 % CI -7.1 to 9.7 , P = 0.75 ) and in the trimmed observational cohort ( n = 185 , adjusted mean difference 0.95 , 95 % CI -2.38 to 4.29 , P = 0.57 ) .