Neonates of mothers vaccinated during pregnancy had significant up-regulation of TGF-1 [ ratio = 1.52 ( 1.22-1 .90 ) , P = 0.0002 ] , and corresponding down-regulation ( P < 0.05 ) of IL-12p70 , IFN - , IL-5 , eotaxin-1 , TARC , MDC , IL-8 in comparison to those vaccinated after pregnancy .