PFS was significantly longer in the BIRIP group ( 3.8 months [ 95 % confidence interval ( CI ) 3.0-4 .7 ] ) than in the irinotecan group ( 2.8 months [ 2.1-3 .3 ] ; hazard ratio 0.68 , 95 % CI 0.47-0 .98 ; P = 0.0398 ) .