Age 41 years or older ( odds ratio [ OR ] , 3.35 ; 95 % CI , 1.1-13 .1 ) , his - tory of diabetes ( OR , 10.7 ; 95 % CI , 2.1-55 ) , and lower baseline CrCl ( OR , 3.1 per 25 mL/min decline ; 95 % CI , 1.7-5 .8 ) were associated with development of RAs .