At the end of the trial , 50 % of the patients in the 33C group ( 235 of 473 patients ) had died , as compared with 48 % of the patients in the 36C group ( 225 of 466 patients ) ( hazard ratio with a temperature of 33C , 1.06 ; 95 % confidence interval [ CI ] , 0.89 to 1.28 ; P = 0.51 ) .