Hepatitis B e antigen ( HBeAg ) - positive CHB patients who had received ETV for 9-36 months , with HBeAg < 100 PEIU/ml and HBV DNA 1000 copies/ml , were randomised 1:1 to receive peginterferon alfa-2a 180 g/week or ETV 0.5 mg/day for 48 weeks .