Major bleeding complications according to modified blood conservation using antifibrinolytics in a randomized trial criteria ( postoperative blood loss > 1500 ml/12 h , re-exploration , red blood cell transfusion > 10 units or death because of bleeding ) were compared in all patients and when ticagrelor/clopidogrel was discontinued 5 days ( n = 280 ) , 2-4 days ( n = 40 ) or 0-1 day before surgery ( n = 85 ) .