In the modified intention-to-treat analysis , the effectiveness was -49.0 % with TDF ( hazard ratio for infection , 1.49 ; 95 % confidence interval [ CI ] , 0.97 to 2.29 ) , -4.4 % with TDF-FTC ( hazard ratio , 1.04 ; 95 % CI , 0.73 to 1.49 ) , and 14.5 % with TFV gel ( hazard ratio , 0.85 ; 95 % CI , 0.61 to 1.21 ) .