In non-LBBB patients with normal PR , CRT-D therapy was associated with a trend toward an increased risk of heart failure/death ( hazard ratio , 1.45 ; 95 % confidence interval , 0.96-2 .19 ; P = 0.078 ; interaction P < 0.001 ) and a more than 2-fold higher mortality ( hazard ratio , 2.14 ; 95 % confidence interval , 1.12-4 .09 ; P = 0.022 ; interaction P < 0.001 ) compared with implantable cardioverter defibrillator therapy .