Cd plus P caused a significant loss of whole body ( P = 0.0001 and P < 0.001 ) and femoral ( P = 0.0005 and P < 0.001 ) bone mineral density ( BMD ) and bone mineral content , respectively , and a loss of fourth lumbar vertebra BMD and bone mineral content ( P < 0.0001 and P < 0.001 , respectively ) .