Compared to placebo , pasireotide suppressed the increase in PR ( 17.12.8 vs 8.23.5 bpm ; p < 0.05 ) and late HG ( nadir glycemia 55.64.3 vs 83.39.5 mg/dL ; p = 0.007 ) , increased peak glycemia ( 294.133.3 vs 221.023.1 mg/dL ; p = 0.001 ) and delayed GE of solids ( t1/2 8323 vs 439min ; p = 0.05 ) and liquids ( t1/2 7010 vs 404min , p = 0.05 ) .