In the overall efficacy-analyses data set ( n = 270 ) , the effect size estimates for edivoxetine doses 0.1 mg/kg/day , 0.2 mg/kg/day and 0.3 mg/kg/day at the week 8 time point were 0.17 , 0.51 , and 0.54 , respectively ( for the stimulant-nave stratum , the effect size estimate for OROS MPH was 0.69 ) .