The concentration of E2 on the indicated days ( 5 days , 8 days , 10 days after hCG injection ) in experiment group and control group were ( 5 7272 089 ) versus ( 11 8264 281 ) pmol/L , ( 1 613879 ) versus ( 7 9253 507 ) pmol/L , ( 193 90 ) versus ( 1 628888 ) pmol/L ; the concentration of VEGF on the indicated days in the two groups were ( 8014 ) versus ( 10819 ) ng/L , ( 6611 ) versus ( 12614 ) ng/L , ( 487 ) versus ( 14814 ) ng/L ; the concentration of E2 and VEGF were lower than those in control group ( all P < 0.01 ) .