After 2 weeks , significantly more subjects who received esomeprazole 20mg ( 50.5 % [ 95 % confidence interval : 43.8 % -57.1 % ] and 39.4 % [ 31.2 % -47.6 % ] in trials 1 and 2 , respectively ) had resolution of sleep disturbances compared to placebo ( 19.9 % [ 14.6 % -25.2 % ] and 16.0 % [ 9.6 % -22.4 % ] , respectively ; p < 0.0001 for both trials ) .