Thirty patients with CRS were randomized in three groups depending on the route of corticosteroids administration : 16 days by oral route ( Medrol ( Pfizer , Belgique ) , 32 mg/8 days -16 mg/4 days-8 mg/4 days ) ; nasal spray ( Rhinocort ( AstraZeneca , Belgique ) , 2 2 64 g/nostril ) ; or sonic nebulization ( Pulmicort ( AstraZeneca , Belgique ) , 2 1 mg/4 mL ) ( Sonic nebulizer , AOHBOX-NL11SN , DTF , France ) .