We studied 169 patients included at a single center in the TTM-trial , randomly assigned to TTM at 33 C or 36 C for 24 h. Plasma samples were analyzed for inflammatory markers including interleukin ( IL ) IL-1 , IL-4 , IL-6 , IL-10 , tumor necrosis factor - ( TNF - ) , C-reactive protein ( CRP ) and procalcitonin ( PCT ) at randomization and 24 , 48 and 72 h after CA .