The regulating spleen-stomach needling is an effective method for treatment of DN , which cold improve glycometabolism disturbance-induced progressive kidney injury , recover glomerular filtration , reduce urinary albumin excretion rate , restrain overexpression of MCP-1 , adjust level of oxidative stress , prohibit oxidation of protein , increase protectiveness of membrane , adjust quantity and activity abnormity of T lymphocyte subgroup , leading to repairing lymphocyte damage and improving immune expression to delay kidney damage .