At T1 , the BMI-SD scores were significantly reduced from 2.32 to 1.80 ( p < 0.0001 ) in Arm A and from 2.23 to 1.99 ( p < 0.05 ) in Arm B. Acanthosis nigricans was significantly reduced in Arm A ( 13.2 % to 5.6 % ; p < 0.05 ) , and glycosylated-haemoglobin levels were significantly reduced in Arms A ( p < 0.005 ) .