According to a 2 2 factorial design , 86 overweight/obese individuals with a large waist circumference and any other component of the metabolic syndrome were randomly assigned to an isoenergetic diet 1 ) poor in LCn3s and polyphenols , 2 ) rich in LCn3s , 3 ) rich in polyphenols , or 4 ) rich in LCn3s and polyphenols .