In the per-protocol analysis , 828 infants were included in group A , 826 in group B , 862 in group C , and 848 in group D. 67 ( 8 % ) infants failed treatment in group A compared with 51 ( 6 % ) infants in group B ( risk difference -19 % , 95 % CI -44 to 01 ) , 65 ( 8 % ) in group C ( -06 % , -31 to 20 ) , and 46 ( 5 % ) in group D ( -27 % , -51 to 03 ) .