Forty-six eyes of 31 adult patients ( 20 females and 11 males ) mean age 39 years , affected by inflammatory ME , were randomized to receive a dose of commercial 0.5 % INDOM eye-drops four times per day ( 16 subjects = 23 eyes ) or placebo ( the vehicle of INDOM , 15 subjects = 23 eyes ) during a 6-month active therapy follow-up .