Women in the highest versus lowest quartile of plasma homocysteine had modestly , but statistically non-significant , increased risks of total AMD ( hazard ratio , HR , 1.24 , 95 % confidence interval , CI , 0.95-1 .63 ; p for trend 0.07 ) and visually significant AMD ( HR 1.41 , 95 % CI 0.92-2 .17 ; p for trend 0.052 ) in age - and treatment-adjusted analyses .