TCZ + PBO ( n = 32 ) demonstrated mean improvements in synovitis from baseline to weeks 2 ( -0.92 ; p = 0.0011 ) , 12 ( -1.86 ; p < 0.0001 ) and 52 ( -3.35 ; p < 0.0001 ) , while TCZ + MTX ( n = 31 ) had mean improvements in synovitis at week 12 ( -0.88 ; p = 0.0074 ) , but not week 52 ( -1.00 ; p = 0.0711 ) .