Toxicities were more common with CP versus CD , including grade 3/4 neutropenia ( 40.8 % versus 27.5 % ; P = 0.025 ) , nausea ( 4.8 % versus 3.1 % ; P = 0.47 ) , allergic reaction ( 8 % versus 3.1 % ; P = 0.082 ) sensory neuropathy ( 4.8 % versus 2.3 % ; P = 0.27 ) and grade 2 alopecia ( 88 % versus 9.2 % ; P < 0.001 ) .