Participants ( age 18 years ) with hypertension but with blood pressure less than 180/110 mm Hg were randomly assigned ( 2:2:2:2:2:2:2:1 ) by a 24-h interactive web response system in blocks of 15 to 4 weeks of double-blind treatment with nebivolol and valsartan fixed-dose combination ( 5 and 80 mg/day , 5 and 160 mg/day , or 10 and 160 mg/day ) , nebivolol ( 5 mg/day or 20 mg/day ) , valsartan ( 80 mg/day or 160 mg/day ) , or placebo .