The cure time was 12.1 4.3 , 11.9 4.0 weeks in negative control ( placebo ) group and positive control ACV group respectively ( P = 0.991 ) , which was longer than that in test GCV group ( 8.6 2.8 weeks ) and there was a significant difference between test GCV group and negative control ( placebo ) group or positive control ACV group ( P = 0.000 ) .