Least squares means ( SE ) change from baseline in log transformed HIV-1 RNA at week 48 was -1.42 ( 0.27 ) and -0.95 ( 0.28 ) copies/mL for lersivirine 750 mg and 1,000 mg qd , respectively , versus -2.02 ( 0.26 ) copies/mL for etravirine 200 mg bid ( ITT ) .