In models adjusted for age , sex , and race , irisin was negatively associated with HDL cholesterol ( 7.3 % decrease per a 10mg/dL increment ; 1.0 % , 13.3 % ; P = 0.02 ) and large HDL particles ( 15.5 % decrease per a 1-SD or 3.5-mol / L increment ; 5.2 % , 24.7 % ; P = 0.005 ) .