Indeed , baseline level of Ang-2 above 5ng/mL was confirmed as an independent prognostic factor for progression free survival ( HR = 0.357 ; 95 % CI : 0.168-0 .76 , p = 0.005 ) and overall survival ( HR = 0.226 ; 95 % CI : 0.098-0 .53 , p = 0.0002 ) .