We found a significant effect of whole-grain intake on serum levels of high-sensitive C-reactive protein ( -21.8 versus +12.1 % , p = 0.03 ) , soluble intercellular adhesion molecule-1 ( -28.4 versus +6.3 % , p = 0.02 ) , serum amyloid A ( -17.4 versus +9.9 % , p = 0.02 ) , and leptin ( -9.7 versus +39.2 % , p = 0.02 ) after 6 weeks .