The SMART regimen resulted in higher inhaled corticosteroid exposure ( 9435 g budesonide per day [ 15025 ] vs 6843 g budesonide per day [ 3905 ] , respectively ; ratio of means 122 [ 106-141 ] ; p = 0006 ) , but reduced oral corticosteroid exposure ( 775 mg prednisone [ 2405 ] vs 1266 mg prednisone [ 3821 ] , respectively ; p = 0011 ) , with no significant difference in composite systemic corticosteroid exposure ( 7937 mg prednisone equivalent per year [ 8931 ] vs 7721 mg prednisone equivalent per year [ 10627 ] , respectively ; 103 [ 086-122 ] ; p = 076 ) .