Patients were hepatitis B e antigen ( HBeAg ) - positive or HBeAg-negative , with levels of HBV DNA 3 log10 IU/mL and lamivudine resistance mutations ( HBV polymerase or reverse transcriptase amino acid substitutions rtM204I/V rtL180M by INNO-LiPA Multi-DR v3 ; Innogenetics , Inc , Alpharetta , GA ) .