Cross-sectional analyses revealed statistically significant relationships between TLFI and liver mean PDFF ( R 2 = 0.740 baseline/0 .791 follow-up , P < 0.001 baseline/P < 0.001 follow-up ) , and between TLFI and liver volume ( R 2 = 0.352 / 0.452 , P < 0.001 / < 0.001 ) .