In the experimental and control groups , DFS was similar in the intention-to-treat population ( hazard ratio [ HR ] 105 ; 95 % CI 085-129 ; p = 066 ) , and in patients with KRAS exon 2/BRAF wild-type ( n = 984 , HR 099 ; 95 % CI 076-128 ) or KRAS exon 2-mutated tumours ( n = 742 , HR 106 ; 95 % CI 082-137 ) .