Weight loss of 5 % or greater occurred in 54.3 % with liraglutide ( 3.0 mg ) and 40.4 % with liraglutide ( 1.8 mg ) vs 21.4 % with placebo ( estimated difference for liraglutide [ 3.0 mg ] vs placebo , 32.9 % [ 95 % CI , 24.6 % to 41.2 % ] ; for liraglutide [ 1.8 mg ] vs placebo , 19.0 % [ 95 % CI , 9.1 % to 28.8 % ] ; P < .001 for both ) .