Dapagliflozin significantly lowered both the fasting and 2-hour plasma glucose concentrations and the incremental area under the plasma glucose concentration curve ( G0-120 ) during OGTT by -33 5 mg/dL , -73 9 mg/dL , and -60 12 mg/dL min , respectively , compared to -13 9 , -33 13 , and -18 9 reductions in placebo-treated subjects ( both P < .01 ) .