Patients were randomized ( 1:2:2:1 ) to receive standard of care , which consisted of definitive fracture fixation within seventy-two hours of injury with a locked intramedullary nail after reaming ; standard of care and injection with 1.0 mg/mL of rhBMP-2 / CPM ; standard of care and injection with 2.0 mg/mL of rhBMP-2 / CPM ; or standard of care and injection with buffer/CPM , to evaluate the activity of the CPM delivery matrix and provide for sponsor and investigator blinding .