At week 12 , compared with isotretinoin only group , isotretinoin with additional antihistamine group showed more statistically significant decrease in acne lesion counts ( non-inflammatory lesions : 44.8 % vs. 17.8 % ; inflammatory lesions : 55.8 % vs. 22.9 % ; total lesions : 45.6 % vs. 18.7 % ; all P < 0.05 ) .