In both regimens , 2-agonist use increased before hospital attendance , with a median ( range ) maximum daily number of actuations of 14 ( 9 to 63 ) budesonide/formoterol in SMART and 46 ( 6 to 95 ) salbutamol in Standard with 4 ( 0 to 10 ) budesonide/formoterol actuations on the day of maximal salbutamol use .