After 6 months of TMZ treatment , no changes were observed in LVEF ( 31 10 % vs 34 8 % ; P = .8 ) , 6MWT ( 443 25 m vs 506 79 m ; P = .03 ) , maximum O2 uptake ( 19.1 5.0 mL kg ( -1 ) min ( -1 ) vs 23.0 7.2 mL kg ( -1 ) min ( -1 ) ; P = .11 ) , functional class ( percentages of patients in functional classes I/II/III / IV 10/3753/0 vs 7/40/50 / 3 ; P = .14 ) , or quality of life ( 32 26 points vs 24 18 points ; P = .25 ) in TMZ versus placebo , respectively .