Seventy-six adults ( 25 males ; age 49.2 1.1 years ; BMI 33.6 0.5 kg/m ( 2 ) ) were randomized to either a hypocaloric ( 6-7 MJ/day ) LC diet ( 35 % protein , 4 % carbohydrate , 61 % fat ) or isocaloric HC diet ( 24 % protein , 46 % carbohydrate , 30 % fat ) for 52 weeks .