Incidence rates ( events/100 patient-yrs ) were reported for serious adverse events ( 8.76 , 95 % CI 7.71 , 9.95 ) , infections ( 44.80 , 95 % CI 41.76 , 48.01 ) , serious infections ( 1.72 , 95 % CI 1.30 , 2.27 ) , malignancies ( 1.19 , 95 % CI 0.86 , 1.66 ) , and autoimmune events ( 1.31 , 95 % CI 0.95 , 1.79 ) .