634/655 patients were evaluable ( Arm A 310 , Arm B 324 ) ; 925 % of Arm A and 91 % of Arm B patients received the preoperative treatment as in the protocol ; 294 patients of Arm A ( 948 % ) and 296 of Arm B ( 913 % ) underwent a radical resection ; complete pathologic response and overall downstaging rates did not show any significant difference in the two arms .