Treatment-naive patients with nonmetastatic N2 or N3 SCCHN were randomly assigned to CRT alone ( CRT arm ; docetaxel , fluorouracil , and hydroxyurea plus radiotherapy 0.15 Gy twice per day every other week ) versus two 21-day cycles of IC ( docetaxel 75 mg/m ( 2 ) on day 1 , cisplatin 75 mg/m ( 2 ) on day 1 , and fluorouracil 750 mg/m ( 2 ) on days 1 to 5 ) followed by the same CRT regimen ( IC + CRT arm ) .