This double-blind , randomized , placebo-controlled crossover intervention consisted of 2 substudies , one with a low-genistein ( LG ) supplement ( 56 % daidzein + daidzin , 16 % genistein + genistin , and 28 % glycitein + glycitin ) and the other with a high-genistein ( HG ) supplement ( 49 % daidzein + daidzin , 41 % genistein + genistin , and 10 % glycitein + glycitin ) .