WBC , N , IL-6 , PT , and D-D all increased in the treatment group at T1-T3 ( P < 0.05 ) ; CRP and ESR increased at T1-T4 ( P < 0.05 ) ; TT increased at T1-T2 ( P < 0.05 ) ; APTT and FIB increased at T1 ( P < 0.05 ) .