LS mean differences in change in ADPS from baseline to week 5 versus placebo were -0.22 , -0.53 , -0.94 , -0.88 , and -1.01 for the mirogabalin 5 - , 10 - , 15 - , 20 - , and 30-mg/day treatment groups , respectively , and -0.05 in the pregabalin group ( P < 0.05 versus placebo for mirogabalin 15 , 20 , and 30 mg/day ) .