For natamycin-treated cases , an association was found between higher natamycin MIC with larger 3-month infiltrate or scar size ( 0.29 mm ; 95 % CI , 0.15-0 .43 ; P < 0.001 ) and increased perforations ( odds ratio , 2.41 ; 95 % CI , 1.46-3 .97 ; P < 0.001 ) .