After a median follow-up of 70 years ( interquartile range [ IQR ] 45-63 ) , 140 ( 26 % ) of 545 patients given EC-P every 3 weeks , 157 ( 29 % ) of 544 patients given FEC-P every 3 weeks , 111 ( 22 % ) of 502 patients given EC-P every 2 weeks , and 113 ( 23 % ) of 500 patients given FEC-P every 2 weeks had a disease-free survival event .