Allocation to r-tPA was associated with an increase in OHS 0 to 2 ( 84 % r-tPA versus 65 % control ; adjusted odds ratio , 3.31 ; 95 % confidence interval , 1.24-8 .79 ) and a favorable shift in OHS distribution ( adjusted odds ratio , 2.38 ; 95 % confidence interval , 1.17-4 .85 ) .