Antiretroviral therapy ( ART ) - naive adults with estimated glomerular filtration rate 70 mL/min were randomized 2:1 to receive the darunavir/cobicistat/emtricitabine / tenofovir alafenamide ( D/C/F / TAF ) STR ( TAF : N = 103 ) or darunavir + cobicistat + emtricitabine/tenofovir disoproxil fumarate ( TDF : N = 50 ) once daily with matched placebos for 48 weeks .