Higher reliever use ( RR 1.63 [ 95 % CI , 1.36-1 .95 ] per categorical score in Asthma Control Questionnaire question no. 6 ) , Mori ethnicity ( RR 2.20 [ 95 % CI , 1.43-3 .38 ] ) and FEV % predicted ( RR 1.16 [ 95 % CI , 1.03-1 .31 ] per 10 % lower ) were associated with future extreme - agonist overuse .