First , in an a priori substudy of a multicenter , randomized , double-blind , placebo-controlled trial of hydrocortisone ( 200 mg/d for 7 d ) in patients with severe trauma , we have measured the blood levels of five cytokines ( tumor necrosis factor - , interleukin-6 , interleukin-10 , interleukin-12 , interleukin-17 ) at day 1 and day 8 .