In comparison to saline administration , tetrastarch administration resulted in significantly decreased R ( P = .017 ) in healthy dogs , as well as significantly increased activated partial thromboplastin time ( P .016 ) , CL30 % ( P .016 ) , and K ( P < .001 ) and significantly decreased platelet count ( P = .019 ) , ( P .001 ) , MA ( P < .001 ) , and von Willebrand factor antigen ( P < .001 ) and collagen binding activity ( P .003 ) in both healthy dogs and dogs with systemic inflammation .