Subjects taking RAL by chewing had significantly higher drug exposure ( RAL area under the curve [ AUC ] ( 0-24 ) : 40722 14843 versus 21753 12229 ng h/mL , P < 0.0001 ) and reduced pharmacokinetic variability compared with those taking the drug by swallowing the whole tablet , with no difference in the minimum RAL concentrations ( RAL C ( min ) : 36 23 versus 43 23 ng/mL , P = 0.298 ) .