Corresponding risk estimates were 1.15 ( 1.09-1 .22 ) observationally and 1.06 ( 0.99-1 .14 ) genetically for ischemic cerebrovascular disease , 1.08 ( 1.00-1 .15 ) observationally and 1.04 ( 0.96-1 .13 ) genetically for myocardial infarction , and 1.07 ( 1.02-1 .12 ) observationally and 1.01 ( 0.96-1 .07 ) genetically for ischemic heart disease .