PPI + LLP was most effective in reducing GER episodes ( 69 [ 13 ] to 46 [ 10 ] , P < 0.001 ) and esophageal acid exposure ( median [ interquartile range ] 8.9 % [ 3.1 % -18.1 % ] to 1.1 % [ 0 % -4.4 % ] , P = 0.02 ) .