Intention-to-treat and per-protocol analyses showed an improved salivary flow rate by 0.04 ml/15 min ( 95 % CI : -0.49 to 0.58 ml/15 min ) and 0.04 ml/15 min ( 95 % CI : -0.52 to 0.60 ml/15 min ) , respectively , but the differences were not significant .