In a randomized controlled trial , 74 sedentary healthy male and female participants either completed 6 months of high-repetition resistance training 3 dwk in accordance with the American College of Sports Medicine recommendations ( RT : n = 37 ; 47 7 yr ; body mass index , 25.0 3.4 kgm ) or served as controls ( CO : n = 37 ; 50 7 yr ; body mass index , 24.2 3.2 kgm ) .