The point estimates ( 90 % CI ) of the geometric mean ratios for co-administration of digoxin with lacosamide versus digoxin alone for AUC ( 24 , ss ) [ 1.024 ( 0.979-1 .071 ) ] and C ( max , ss ) [ 1.049 ( 0.959-1 .147 ) ] were within the acceptance range for bioequivalence .