One dose of Vi-CRM197 significantly increased concentrations of anti-Vi antibody in adults ( from 113 U/mL [ 95 % CI 67-190 ] to 208 U/mL [ 117-369 ] ) , children ( 201 U/mL [ 138-294 ] to 368 U/mL [ 234-580 ] ) , and older infants ( 179 U/mL [ 129-250 ] to 249 U/mL [ 130-477 ] ) .