At six months , decreases in weight and blood variables were statistically significantly greater in the metformin arm ( vs placebo ) in univariate analyses : weight -3.0 % , glucose -3.8 % , insulin -11.1 % , homeostasis model assessment -17.1 % , leptin -20.2 % , hs-CRP -6.7 % ; all P values were less than or equal to .03 .