HIV-infected adult patients ( 16 years of age ) with no previous antiretroviral therapy , a CD4 cell count of 50-500 cells per L , and plasma HIV-1 viral load of at least 1000 copies per mL were randomly assigned ( 1:1 ) by an electronic case report form to receive fixed-dose daily tenofovir 300 mg and emtricitabine 200 mg plus efavirenz either 400 mg daily or 600 mg daily .