After 48-week sevelamer treatment , there were significant changes with lower LDL-C ( from 2.820.78 to 1.650.53 mmol/L , P = 0.000 ) , lower FGF23 ( from 2465.97 ( 2568.88 ) to 795.61 ( 1098.39 ) , P = 0.000 ) and higher s-Klotho levels ( from 189.35 ( 161.88 ) to 252.94 ( 517.80 ) pg/mL , P = 0.000 ) .