The minor alleles of IL10 tagSNPs rs1800890 ( A ; OR = 0.87 , 95 % CI : 0.75-0 .99 ; P-trend = 0.04 ) and rs3021094 ( C ; OR = 1.31 , 95 % CI 1.03-1 .66 , P-trend = 0.03 ) were associated with risk ; the latter also with lower - ( P-trend = 0.04 ) and possibly higher - ( P-trend = 0.06 ) grade disease .