There were amelioration of haemodinamic instability , especially in MARS-group ( increase in ADmean was 17 % in MARS ( p = 0.005 ) and 10 % in Prometheus-group ( p = 0.001 ) ) , increase in P/F ratio ( 12 % in Prometheus-group ( p = 0.07 ) ) , decrease in serum total bilirubin ( 8.6 % in MARS-group ( p = 0.028 ) and 33 % in Prometheus-group ( p < 0.001 ) ) and unconjugated bilirubin levels ( 29 % in Prometheus-group ( p = 0.003 ) ) , also we had decreasing in serum aminotransferase levels and trend to increasing in serum cholinesterase level ( 12 % in MARS-group ( p = 0.87 ) and 8 % in Prometheus-group ( p = 0.86 ) ) .