The patients were randomized into 3 groups : 1 ) 20 patients took diclofenac sodium 100 mg/day ; 2 ) 30 received a complex pharmaceutical on the basis of glycozaminoglycans Alflutop injection 1 ml per day for 20 days , then 2 ml intraartricular twice weekly in the following month ; 3 ) 36 had diacerein ( diaflex , `` Rompharm Company '' ) in a dose of 50 mg twice daily for 3 months .