Height velocity and standard deviation ( SD ) score ; levels of insulin-like growth factor 1 ( IGF-1 ) , osteocalcin ( OC ) , and C-telopeptide of type I collagen ( CTX-I ) ; and Juvenile Arthritis Disease Activity Score in 71 joints ( JADAS-71 ) were measured in a post hoc analysis of 83 patients who never received growth hormone and did not reach Tanner stage 5 by the end of the first year of treatment .