Improvement in PVR and mean pulmonary artery pressure ( MPAP ) over a 24-week period was significantly associated with improvement in RV FWLS ( r = 0.39 , P = 0.02 ; 0.33 , P = 0.04 respectively ) , LV global CS ( r = 0.61 , P = 0.0001 ; r = 0.60 , P = 0.0001 , respectively ) , and LV septal CS ( r = 0.50 , P = 0.005 ; r = 0.56 , P = 0.002 , respectively ) .