We compared rates of alanine aminotransferase ( ALT ) elevationgrade 3 ( ALT5 .1 times the upper limit of normal ) and graded bilirubin elevations in HIV-negative opioid injectors randomized to long-term ( 52 weeks ) or short-term ( 18 days ) medication assisted treatment ( LT-MAT and ST-MAT , respectively ) with BUP/NX in a multisite trial conducted in China and Thailand .