Methazolamide treatment was associated with a HbA1c of -0.39 % ( 95 % CI -0.82 , 0.04 ; P < 0.05 ) ( -4.3 mmol/mol [ -9.0 , 0.4 ] ) , an increase in the proportion of patients achieving HbA1c 6.5 % ( 48 mmol/mol ) from 8 to 33 % , a rapid reduction in alanine aminotransferase ( 10 units/L ) , and weight loss ( 2 % ) in metformin-cotreated patients .