The 2 schedules alternating AS03-and MF59-adjuvanted formulations led to lower geometric mean titers ( GMTs ) of ( 41.5 [ 95 % CI , 31.7-54 .4 ] ; n = 92 ) and ( 58.6 [ 95 % CI , 44.3-77 .6 ] ; n = 96 ) than the group induced by 2 AS03-adjuvanted formulations ( n = 96 ) ( 103.4 [ 95 % CI , 78.7-135 .9 ] ; P < .001 ) but higher GMTs than 2 doses of MF59-adjuvanted formulation ( n = 94 ) ( 29.0 [ 95 % CI , 22.4-37 .6 ] ; P < .001 ) .