At 2-year biopsy , baseline chronic inflammation was associated with lower mean tumor volume ( 2.07 l vs. 3.15 l ; P = 0.001 ) , number of biopsy cores involved ( 1.78 vs. 2.19 ; P < 0.001 ) , percent of cores involved ( 17.8 % vs. 22.8 % ; P < 0.001 ) , core involvement ( 0.21 l vs. 0.31 l ; P < 0.001 ) , and overall percent tumor involvement ( 1.40 % vs. 2.01 % ; P < 0.001 ) .