Vytorin mostly altered the expression levels of genes related to inflammation/oxidative stress ; it downregulated the NF-KappaB and upregulated the expression of anti-inflammatory cytokine , IL-10 , and anti-oxidant enzymes , GPX1 and SOD2 , but also upregulated the expression levels of genes involved in cellular activation , adhesion , and coagulation cascade , including VWF , F7 , PF4 , PF4V1 SELP , ITGB3 , ITGB5 .