Single locus analysis showed that AT1 A1166C ( p value < 0.001 ; OR = 3.67 ) , MMP9 R668Q ( p value = 0.007 ; OR = 3.48 ) and NFKB1-94 ATTG ins/del ( p value = 0.013 ; OR = 2.01 ) polymorphisms were independently associated with LVD when compared with both non-LVD patients and healthy controls .