Among treated patients the strongest independent predictors of HBsAg loss were Caucasian race with genotype A/D and 4 years of infection ( HR = 14.3 , 95 % confidence interval [ CI ] 4.7-43 .4 ; p < 0.0001 ) and an HBsAg decline of 1 log10 IU/ml at week 24 ( HR = 13.7 , 95 % CI 5.6-33 .7 ; p < 0.0001 ) .