The geometric least squares ( LS ) mean of the RatioAUC and RatioCmax for plasma glucose after the FDC vs. loose combination , and the LS mean of the ratios in metformin AUC , AUC0-last and Cmax were close to unity , and the 90 % CI of all these parameters fell within the predefined equivalence range of 08-125 , confirming bioequivalence .