After the treatment period , mean ( SD ) global modified BPI-7S score improved from 39.7 ( 15.9 ) at baseline to 31.6 ( 16.8 ) for a mean change of -8.6 ( 95 % confidence interval CI -10.5 , -6.7 ; P < 0.0001 ) , and 74.5 % of patients reported improvement in overall status ( PGIC ) compared with 25.5 % who reported no change or worsening ( P < 0.001 ) .