In patients untreated with ICS at baseline , Arg16Gly and Arg16Arg genotypes were associated with significantly prolonged time to first exacerbation compared with Gly16Gly ( vs Arg16Gly p = 00164 ; Arg16Arg p = 00316 ; proportion of patients with at least one exacerbation was 283 % in Arg16Arg , 316 % in Arg16Gly , and 392 % in Gly16Gly ) , whereas in patients on ICS at baseline , only the Arg16Arg genotype was associated with significantly prolonged time to first exacerbation compared with Gly16Gly ( p = 00198 ; not Arg16Gly p = 064 ; proportion of patients with at least one exacerbation was 359 % in Arg16Arg , 467 % in Arg16Gly , and 448 % in Gly16Gly ) .