Of the patients who received placebo , there was a statistically significant improvement demonstrated in the O'Leary-Sant Interstitial Cystitis Symptom and Problem Indexes of -8.1 ( 95 % confidence interval [ CI ] , 3.0-13 .2 ) , Interstitial Cystitis Symptom Index of -3.7 ( 95 % CI , 0.9-6 .5 ) , Interstitial Cystitis Problem Index of -4.4 ( 95 % CI , 2.0-6 .8 ) , and Pelvic Pain , Urgency , Frequency scale of -6.9 ( 95 % CI , 2.8-11 .0 ) at week 12 compared with baseline .