Following preliminary testing , 8 male patients ( 242 years , HbA1c 7.70.4 % / 614 mmol.l-1 ) treated with insulin 's glargine and aspart , or lispro attended the laboratory on two mornings at 08:00 h and consumed a standardised breakfast carbohydrate bolus ( 1 g carbohydrate.kg-1BM ; 38010 kcal ) and self-administered a 75 % reduced rapid-acting insulin dose 60 minutes before 45 minutes of intensive treadmill running at 73.10.9 % VO2peak .