The assessed variables were D-dimers , fibrinogen , prothrombin time , activated partial thromboplastin time , coagulation factors ( F ) II , V , VII , VIII , IX , X , and XI , antithrombin ( AT ) , protein C , free protein S , tissue plasminogen activator ( t-PA ) , 2-antiplasmin , thrombin-antithrombin complex , and prothrombin fragment 1 +2 .