This double-blind study randomized 267 uncontrolled type 2 diabetes patients ( HbA1c 7.5 % and 11.5 % ) , post 3 months ' treatment with glimepiride/gliclazide and metformin , to additionally receive hydroxychloroquine 400mg/day ( n = 135 ) or pioglitazone 15mg/day ( n = 132 ) for 24 weeks .