Doxazosin markedly improved IPSS ( from 16.2 0.7 to 9.5 0.5 ) , maximum urinary flow rate ( from 10.9 0.7 to 12.8 0.6 ml/s ) and PVR urine ( from 68.1 9.4 to 39.0 4.4 ml ) ( p < 0.0001 , p < 0.0001 , p = 0.0004 , respectively ) .