For translational studies , we assessed the effect of oxidative insults in mice systemically prechelated with deferiprone ( DFP ) by following motor functions , striatal dopamine ( HPLC and MRI-PET ) , and brain iron deposition ( relaxation-R2 * - MRI ) aided by spectroscopic measurements of neuronal labile iron ( with fluorescence-sensitive iron sensors ) and oxidative damage by markers of protein , lipid , and DNA modification .