The proportion of infants who required surgical closure of a patent ductus arteriosus was lower in the budesonide group than in the placebo group ( relative risk , stratified according to gestational age , 0.55 ; 95 % CI , 0.36 to 0.83 ; P = 0.004 ) , as was the proportion of infants who required reintubation ( relative risk , stratified according to gestational age , 0.58 ; 95 % CI , 0.35 to 0.96 ; P = 0.03 ) .