Compared with ticagrelor alone , the geometric least squares mean ( LSM ) ratio ( 90 % confidence interval [ CI ] ) for the ticagrelor area under the plasma concentration-time curve from time zero to infinity ( AUC ( ) ) was 2.83 ( 2.63-3 .06 ) , and the maximum plasma concentration ( C ( max ) ) was 2.30 ( 2.06-2 .58 ) , in the presence of cyclosporine .