The hazard of acquisition of high-viral load infections in the glans was lower in the circumcision arm , compared with the control arm , for HPV-16 ( hazard ratio [ HR ] , 0.32 [ 95 % confidence interval { CI } , .20 -.49 ] ) and HPV-18 ( HR , 0.34 [ 95 % CI , .21 -.54 ] ) .