Patients with stage III or IV ( or stage II base of tongue ) SCC ( n = 1076 ) were randomized to 4 treatment arms : ( 1 ) SFX , 70 Gy/35 daily fractions/7 weeks ; ( 2 ) HFX , 81.6 Gy/68 twice-daily fractions/7 weeks ; ( 3 ) AFX-S , 67.2 Gy/42 fractions/6 weeks with a 2-week rest after 38.4 Gy ; and ( 4 ) AFX-C , 72 Gy/42 fractions/6 weeks .