Administration of probiotics significantly decreased the proportion of patients suffering from irritable bowel symptoms ( 0 week vs. 12 week ; 67.9 % vs. 45.7 % , p = 0.03 ) , improved colorectal cancer-related FACT ( baseline vs. 12 weeks : 19.79 4.66 vs. 21.18 3.67 , p = 0.04 ) and fatigue-related FACT ( baseline vs. 12 weeks : 43.00 ( 36.50-45 .50 ) vs. 44.50 ( 38.50-49 .00 ) , p = 0.02 ) and PHQ-9 scores ( 0 weeks vs. 12 weeks ; 3.00 ( 0-8 .00 ) vs. 1.00 ( 0-3 .00 ) , p = 0.01 ) .