At D28 , improvement was significantly better for TBUT [ CE : 1.7 2.4 s ; PVA-P : 0.6 1.8 s ; P = 0.015 ] and for the Van Bijsterveld score [ CE : -1.4 1.2 ; PVA-P : -0.9 1.2 ; P = 0.046 ] in the CE group .