Three mg/kg pioglitazone significantly improved insulin sensitivity ( geometric mean [ 95 % CI ] 0.90 [ 0.64-1 .28 ] to 2.03 [ 1.49-2 .78 ] minpmolL ; P = .0014 versus change with placebo ) , reduced insulin area under the curve during IVGTT ( geometric mean [ range ] 27 [ 9-64 ] to 18 [ 6-54 ] minnmol/L ; P = .0031 versus change with placebo ) , and lowered serum triglyceride ( geometric mean [ range ] 71 [ 29-271 ] to 48 [ 27-75 ] mg/dL ; P = .047 versus change with placebo ) and cholesterol ( geometric mean [ range ] 187 [ 133-294 ] to 162 [ 107-249 ] mg/dL ; P = .0042 versus change with placebo ) concentrations in the obese cats .