We prospectively examined randomization to first-step chlorthalidone , a thiazide-type diuretic ; amlodipine , a calcium-channel blocker ; and lisinopril , an angiotensin-converting enzyme inhibitor , on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [ kg/m ( 2 ) ; normal weight ( BMI < 25 ) , overweight ( BMI = 25-29 .9 ) , and obese ( BMI > 30 ) ] .