Both binders produced similar reductions from baseline in LDL-C level ( P < 0.001 ) , and responder rates after 1 year , using a target of < 1.83 mmol/L ( 70 mg/dL ) or < 2.59 mmol/L ( 100 mg/dL ) were similar in both groups ( 50.7 and 85.3 % for colestilan and 54.0 and 80.6 % for sevelamer ) .