Median OS in patients receiving EVE + EXE was 31.0 months [ 95 % confidence interval ( CI ) 28.0-34 .6 months ] compared with 26.6 months ( 95 % CI 22.6-33 .1 months ) in patients receiving PBO + EXE ( hazard ratio = 0.89 ; 95 % CI 0.73-1 .10 ; log-rank P = 0.14 ) .