However , following the mixed meal , plasma glucose area under the response curve increased from 13.12.9 to 14.02.8 mmol/l , p = 0.05 , as a consequence of both increased insulin resistance [ HOMA-IR : 2.2 ( 1.2 , 4.2 ) vs. 3.8 ( 1.3 , 5.5 ) , p = 0.02 ] and a reduced acute insulin response to glucose [ 424 ( 211 , 975 ) vs. 257 ( 122 , 418 ) pmol/mmol , p = 0.04 ] .