The relative risk of viral shedding with pritelivir , as compared with placebo , was 1.11 ( 95 % confidence interval [ CI ] , 0.65 to 1.87 ) with the 5-mg daily dose , 0.57 ( 95 % CI , 0.31 to 1.03 ) with the 25-mg daily dose , 0.13 ( 95 % CI , 0.04 to 0.38 ) with the 75-mg daily dose , and 0.32 ( 95 % CI , 0.17 to 0.59 ) with the 400-mg weekly dose .