The decrease was significantly more pronounced in patients receiving osteopathy at day 30 [ -38.4 ( -76.1 to 10.2 ) vs. 32.2 ( -16.6 to 41.6 ) , P = 0.01 ] , day 45 [ -36.7 ( -74.4 to 25.3 ) vs. 32.2 ( -16.6 to 41.6 ) , P = 0.04 ] , and day 60 [ -39.5 ( -60.9 to -9.2 ) vs. 6.1 ( -38.7 to 28.5 ) , P = 0.05 ] with a concomitant increase in Qol ( P = 0.09 at day 30 , P = 0.02 at day 45 , P = 0.3 at day 60 ) .