Changes of clinical symptoms and signs , fast blood glucose ( FBG ) , urinary albumin excretion rate ( UAER ) , beta2-microglobulin ( beta2-MG ) , monocyte chemotactic protein-1 ( MCP-1 ) , lymphocyte membrane cholesterol , propanediol ( MDA ) , PCO , 8-hydroxydeoxy guanosine ( 8-OHdG ) , superoxide dismutase ( SOD ) , CD3 + , CD4 + , CD8 + , and CD4 + / CD8 + were observed before and after treatment in two groups .