VK1 plasma concentrations were assessed at 0 , 2 , 4 , 5 , 6 , 8 , 10 and 24 h , and the area under the curve was higher in the solution group than in the tablet group ( mean difference 365 g L ( -1 ) h , 95 % confidence interval [ CI ] 230-501 , P < 0.0001 ) .