Treatment in the SMART group consisted of two actuations of budesonide-formoterol ( 200 g and 6 g , respectively , per actuation ) twice daily , delivered through a combination metered dose inhaler ( MDI ) , with one extra actuation as needed for relief of symptoms ; treatment in the standard group consisted of two actuations of budesonide-formoterol ( 200 g and 6 g , respectively , per actuation ) twice daily through a combination MDI with one to two actuations of salbutamol ( 100 g per actuation ) by MDI as needed for relief of symptoms .