One hundred fourteen patients with moderate to severe COPD finished randomized 6-month or 30-month treatment with fluticasone ( 500 g bid ) , 30-month treatment with fluticasone and salmeterol ( 500/50 g bid ) , or placebo ( first part of the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease [ GLUCOLD ] study [ GL1 ] ) .