Manual compression ( OR 3.3 , 95 % CI : 1.5-7 .2 , p = 0.002 ) , female gender ( OR 2.1 , 95 % CI : 1.1-3 .9 , p = 0.018 ) , and multiple punctures ( OR 10.5 , 95 % CI : 3.2-34 .3 , p = 0.001 ) were identified as independent predictors of adverse events and large haematomas .