Participants assigned to acetazolamide also experienced a reduction in weight ( acetazolamide : -7.50 kg , from 107.72 kg to 100.22 kg ; placebo : -3.45 kg , from 107.72 kg to 104.27 kg ; treatment effect , -4.05 kg , 95 % CI , -6.27 to -1.83 kg ; P < .001 ) .