At the end of the study , ANOVA showed that OMT significantly reduced HIT-6 score ( mean change scores OMT-conventional care : -8.74 ; 95 % confidence interval ( CI ) -12.96 to -4.52 ; p < 0.001 and OMT-sham : -6.62 ; 95 % CI -10.85 to -2.41 ; p < 0.001 ) , drug consumption ( OMT-sham : RR = 0.22 , 95 % CI 0.11-0 .40 ; OMT-control : RR = 0.20 , 95 % CI 0.10-0 .36 ) , days of migraine ( OMT-conventional care : M = -21.06 ; 95 % CI -23.19 to -18.92 ; p < 0.001 and OMT-sham : -17.43 ; 95 % CI -19.57 to -15.29 ; p < 0.001 ) , pain intensity ( OMT-sham : RR = 0.42 , 95 % CI 0.24-0 .69 ; OMT-control : RR = 0.31 , 95 % CI 0.19-0 .49 ) and functional disability ( p < 0.001 ) .