When comparing apixaban with warfarin , patients who received amiodarone had a stroke or a systemic embolism rate of 1.24 % / year versus 1.85 % / year ( HR : 0.68 , 95 % CI : 0.40 to 1.15 ) , death of 4.15 % / year versus 5.65 % / year ( HR : 0.74 , 95 % CI : 0.55 to 0.98 ) , and major bleeding of 1.86 % / year versus 3.06 % / year ( HR : 0.61 , 95 % CI : 0.39 to 0.96 ) .