Symptoms were fairly stable and quality of life was normal throughout follow-up in patients remaining on esomeprazole 20mg once daily , with no more than mild symptom severity , and mean ( standard deviation ) percentage time with intraesophageal pH < 4 was reduced from 10.7 ( 10.7 ) pre-randomization to 6.3 ( 10.2 ) at 6 months and 4.9 ( 7.3 ) at 5 years .