Total average crying and fussing times throughout the study ( from baseline to day 21 ) were significantly shorter among infants with colic in the probiotic group compared with infants in the placebo group ( 1719 750 minutes [ 29 13 hours ] vs 2195 764 minutes [ 37 13 hours ] ; P = .028 ) ( relative risk , 0.78 ; 95 % CI , 0.58-0 .98 ) .