The proportion of patients with estimated glomerular filtration rate 90 mL/min per 1.73 m ( 2 ) in the LdT + ADV group increased from 49.1 % ( 26/53 ) at baseline to 58.5 % ( 31/53 ) at week 48 , while that in the LAM + ADV group decreased from 37.7 % ( 20/53 ) at baseline to 30.2 % ( 16/53 ) at week 48 .