No children showed evidence of treatment-related haemolysis , and the mean maximum decrease in haemoglobin concentration was not associated with the dose of primaquine received-it did not differ significantly compared with placebo ( 10.7 g/L , SD 11.1 ) in the 0.1 mg/kg ( 11.4 g/L , 9.4 ; p = 0.61 ) , 0.4 mg/kg ( 11.3 g/L , 10.0 ; p = 0.67 ) , or 0.75 mg/kg ( 12.7 g/L , 8.2 ; p = 0.11 ) primaquine groups .