At the end of the first week after the treatment , the score of NIHSS of the observation group were lower than that of the control group , with significant different ( P < 0.05 ) ; the observation group showed reduced volume of brain edemas than that on admission ( P < 0.05 ) , whereas the control group the control group showed increased volume of brain edemas than that on admission ; the control group displayed increased level of serum AQP4 than that on admission , but without significant difference ; the observation group displayed decreased level of serum AQP4 than that on admission ( P < 0.05 ) .