The mean reduction from baseline in central retinal thickness was 457.2 versus 144.8 m ( P < 0.001 ) at week 24 , 413.0 versus 381.8 m at week 52 ( P = 0.546 ) , and 390.0 versus 343.3 m at week 100 ( P = 0.366 ) in the IAI 2Q4 + PRN and sham + IAI PRN groups , respectively .