At Week 24 with last observation carried forward , colesevelam produced a reduction in total low-density lipoprotein ( LDL ) particle concentration ( baseline : 1,611 nmol/L ; least-squares [ LS ] mean treatment difference : -143 nmol/L , p < 0.0001 ) versus placebo ; reductions were also seen in large , small , and very small LDL particle concentrations ( all p < 0.05 ) .