During the normoglycemic-hyperinsulinemic clamp , flow-mediated dilatation ( FMD ) increased , while soluble intercellular adhesion molecule ( sICAM-1 ) , plasma 8-iso-prostaglandin F2 ( 8-iso-PGF2 ) , nitrotyrosine , and interleukin ( IL ) -6 decreased compared with normoglycemic-normoinsulinemic clamp .