A cohort of Japanese patients with T2DM and mild to moderate RI and poor glycaemic control , despite diet/exercise therapy alone or diet/exercise therapy in combination with an oral hypoglycaemic agent ( an - glucosidase inhibitor , a sulfonylurea , or pioglitazone ) , were randomized in a double-blind manner to 50mg ipragliflozin or placebo once daily for 24weeks .