However , gadobutrol led to significantly higher T1-relaxation times of LVC than Gd-DTPA from 6 to 9 min ( 220 15 ms vs. 195 30 ms p < 0.01 ) onwards , resulting in a significantly greater T1 of IM to LVC at 9-12 min ( -20 35 ms vs. 0 35 ms , p < 0.05 ) and 12-15 min ( -25 45 ms vs. -10 60 ms , p < 0.05 ) .