BAS-G , BASFI , BASDAI , spine pain , pain at night , TCM symptom score , distance between occipital and wall , distance between finger and ground , thoracic activity , spine activity , Schober test , ESR , CRP were observed as the observing indices ; ASAS20 , ASAS50 , ASAS70 , BASDAI50 , and criteria of TCM were explored for clinical evaluation and safety evaluation .