Estimated hourly mean interstitial glucose values based on linear mixed models showed an increase of 0.03 [ SE 0.01 ] mmol/L per hour from 5.0 [ 0.4 ] in patients without KDM and followed a quadratic curve from 5.0 [ 0.4 ] mmol/L at midnight to 7.5 [ 0.5 ] mmol/L at 12:00 h in patients with KDM during control periods .