In addition , in responders , the HMW : T-ADP ratio ( CV -0.04 ; 95 % CI : -0.07 , -0.01 ; p = 0.041 ) decreased and the LMW : T-ADP ratio ( CV 0.04 ; 95 % CI : 0.01 , 0.07 ; p = 0.043 ) increased at 120 minutes after treatment .