Administration of 160 mg darapladib for 3 months resulted in statistically significant mean improvements , from baseline to month 3 , in BCVA of 4.1 Early Treatment Diabetic Retinopathy Study ( ETDRS ) letters ( 95 % confidence interval [ CI ] , 2.3-5 .8 ) and of 57 m in central subfield thickness ( 95 % CI , -84 to -30 ) in the study eyes .