In HIV negative patients given MM compared to placebo , mean villous height was 24.0 % greater ( 293.3 v. 236.6 m ; 95 % CI of difference 17.7-95 .9 m ; P = 0.006 ) , mean villous area was 27.6 % greater ( 27623 v. 21650 m2/100 m ; 95 % CI of difference 818-11130 m2/100 m ; P = 0.03 ) , and median villous perimeter was 29.7 % greater ( 355.0 v. 273.7 m/100 m ; 95 % CI of difference 16.3-146 .2 m/100 m ; P = 0.003 ) .