We conducted a prospective trial at a tertiary care referral institute in New Delhi , India , from January 2012 through March 2013 , of patients with cirrhosis without overt HE ( age , 48.6 11.1 y ; 96 men and 64 women ) ; 25 were Child-Turcotte-Pugh ( CTP ) class A , 51 were CTP class B , and 84 were CTP class C. Subjects were assigned randomly to groups given probiotics ( 1 10 ( 8 ) colony-forming units , 3 times daily ; n = 86 , 42 with minimal HE ) or no test article ( control , n = 74 ; 33 with minimal HE ) .