Loss of protective titres was also observed for those who received the 4CMenB vaccine at 12 , 40 and 42 months ( n = 5 ) ( 80 % -100 % against matched strains , 60 % -100 % against mismatched strains ) or at 40 and 42 months ( n = 29 ) ( 31 % -100 % against matched strains , 41 % -81 % against mismatched strains ) .