Comparing intact tablets , the drug liking Emax ( least squares means [ 95 % confidence interval ] ) was significantly lower for OC/APAP 30/1300 mg ( 76.4 [ 72.8 to 80.0 ] ) than for IR OC/APAP 30/1300 mg ( 85.6 [ 81.9 to 89.2 ] ; difference , -9.2 [ -13.1 to -5.2 ] ; P < 0.001 ) .