Relative to baseline , on day 5 , median change in biomarkers for placebo , 200,000 IU cholecalciferol , and 400,000 IU cholecalciferol groups , respectively , were as follows : 1 ) total 25-hydroxyvitamin D , 3 % ( -3 % to 8 % ) , 49 % ( 30-82 % ) , and 69 % ( 55-106 % ) ( p < 0.001 ) ; 2 ) bioavailable 25-hydroxyvitamin D , 4 % ( -8 % to 7 % ) , 45 % ( 40-70 % ) , and 96 % ( 58-136 % ) ( p < 0.01 ) ; and 3 ) LL-37 : -17 % ( -9 % to -23 % ) , 4 % ( -10 % to 14 % ) , and 30 % ( 23-48 % ) ( p = 0.04 ) .