The adverse drug reactions mainly included hypertension ( 54.1 % ) , hand-foot skin reactions ( 45.8 % ) , diarrhea ( 33.3 % ) , mucositis ( 29.2 % ) , neutropenia ( 45.8 % ) , thrombocytopenia ( 29.2 % ) , hyperlipidemia ( 41.7 % ) and proteinuria ( 41.7 % ) .