Ticagrelor , compared with clopidogrel , reduced the composite of cardiovascular death , myocardial infarction , and stroke in patients with extensive CAD ( 14.9 % vs 17.6 % , hazard ratio [ HR ] 0.85 [ 0.73-0 .98 ] ) similar to its reduction in those without extensive CAD ( 6.8 % vs 8.0 % , HR 0.85 [ 0.74-0 .98 ] , Pinteraction = .99 ) .