24 MS subjects ( EDSS 4.890.54 , 17 female and 7 male , 52.5811.21 years , MS duration 15.218.68 years ) have been enrolled and randomly assigned to 2 treatment groups : ( i ) experimental group received 10 TOCT sessions over 2 weeks ( 2 hours/each session ) followed by a 3 months home exercise program , whereas control group did not receive any specific rehabilitation intervention .