The mean ( 95 % CI ) decreases versus placebo in nighttime SBP were statistically significant with all 3 etamicastat doses ( 50 mg , -11.66 mm Hg [ -21.57 to -1.76 ; P < 0.05 ] ; 100 mg , -14.92 mm Hg [ -24.98 to -4.87 ; P < 0.01 ] ; and 200 mg , -13.62 mm Hg [ -22.29 to -3.95 ; P < 0.01 ] ) .