Patients randomized to high-dose edoxaban had fewer strokes on-treatment ( hazard ratio , 0.80 ; 95 % confidence interval , 0.65-0 .98 ) than warfarin ( median time-in-therapeutic range , 68.4 % ) ; patients in the low-dose edoxaban group had similar rates ( hazard ratio , 1.10 versus warfarin ; 95 % confidence interval , 0.91-1 .32 ) .