MK-7123 caused a dose-dependent decrease in absolute neutrophil count ( ANC ) and reduced inflammatory biomarkers matrix metallopeptidase-9 and myeloperoxidase in plasma and sputum ; ANC lower than 1.510 ( 9 ) / L led to discontinuations with higher doses of MK-7123 ( 18 % in the MK-7123 50-mg group vs. 1 % in placebo ) .