IL - 6 increased significantly at both 5 and further at 24 h after surgery ( 3.2 , 4.5 and 5.1 base-line , 5 and 24-h respectively ) , the IL-6 increase showed different patterns between the 2 groups ; IL-6 was significantly increased in the control group of patients between preoperative baseline and 24 h after surgery ( p = 0.008 ) also between 5 h and 24 h , ( p = 0.006 ) after surgery while the AAI-group had only minor non-significant changes .