Liraglutide treatment ( n = 24 ) significantly ( p0 .03 ) increased the insulin secretion rate ( % mean change [ 95 % CI ] ; 21 % [ 12 , 31 ] vs -4 % [ -11 , 3 ] ) and pancreatic beta cell sensitivity to intravenous glucose ( 229 % [ 161 , 276 ] vs -0.5 % ( -15 , 14 ] ) , and decreased insulin clearance rate ( -3.5 % [ -11 , 4 ] vs 8.2 [ 0.2 , 16 ] ) as compared with placebo ( n = 25 ) .