Grade 3 or 4 adverse drug reactions were neutropenia ( 20 % with SOL vs 41 % with mFOLFOX6 ) , sensory neuropathy ( 20 vs 2.0 % ) , anorexia ( 13 vs 7.8 % ) , fatigue ( 11 vs 5.9 % ) , and diarrhea ( 11 vs 3.9 % ) .