Both doses of UMEC plus VI also improved trough FEV1 compared with VI monotherapy ( UMEC 125 g plus VI 25 g : 0088 L [ 0036 to 0140 ; p = 00010 ] ; UMEC 625 g plus VI 25 g : 0090 L [ 0039 to 0142 ; p = 00006 ] , but not compared with UMEC 125 g monotherapy ( UMEC 125 g plus VI 25 g : 0037 L [ -0012 to 0087 ; p = 014 ] ; UMEC 625 g plus VI 25 g : 0022 L [ -0027 to 0072 ; p = 038 ] ) .