After 3 months of treatment , VAS , RQLQ , FENO of all patients was significantly decreased ( P < 0.05 ) ; VAS , RQLQ score was not significantly different among the three groups ( P > 0.05 ) , FENO value has no statistically significant difference between group A and group B ( P > 0.05 ) , but were less than that in group C ( P < 0.05 ) .