Among sexually active women , Female Sexual Function Index domain score change from baseline differences ( active compared with placebo ) in desire was 0.3 ( 95 % CI 0.0-0 .6 ) for estradiol , -0.6 ( 95 % CI -1.2 to 0.0 ) in orgasm for venlafaxine , and 0.9 ( 95 % CI 0.2-1 .6 ) in penetration pain for venlafaxine .