The UHC patients treated with PDT plus S-1 showed higher 1-year survival rate compared with the patients treated with PDT alone ( 76.2 % versus 32 % , P = 0.003 ) and prolonged overall survival ( median 17 months , 95 % confidence interval [ CI ] : 12.6-21 .4 , versus 8 months , 95 % CI : 6-10 , P = 0.005 , hazard ratio [ HR ] , 0.36 ; 95 % CI : 0.17-0 .75 ) .