A decision tree was developed based on the Clinical Protocol and Therapeutic Guidelines for Ulcerative Colitis , published by the Ministry of Health in the lobby SAS/MS n 861 of November 4 th , 2002 and on the algorithms published by the Associao Brasileira de Colite Ulcerativa e Doena de Crohn , aiming to get the cost-effectiveness of mesalazine once daily in granules compared with mesalazine twice daily in tablets .