No significant improvement was found in any of the primary or secondary outcomes , apart from a significant reduction in mean systolic ( -4.65 mmHg , 95 % CI 9.18 to -0.12 ; P = 0.04 ) and diastolic blood pressure ( -3.30 mmHg , 95 % CI -5.35 to -1.26 ; P = 0.002 ) .