During CPB , the mean cumulative dose of noradrenaline administered was 13.48 gkg ( -1 ) ( 95 % CI 10.52 to 17.19 ) in group Sevo1 .8 % and 4.06 gkg ( -1 ) ( 95 % CI 2.67 to 5.97 ) in group SevoBIS ( P < 0.001 ) .