Among patients aged 65 years , the adjusted hazard ratio ( HR ) for survival without grade 3-4 toxicity ( HR 0.40 , 95 % confidence interval [ CI ] 0.23-0 .70 ) favored pemetrexed + carboplatin ; this was similar to the HRs in patients aged 70 years ( HR 0.43 , 95 % CI 0.20-0 .92 ) , patients aged < 70 years ( HR 0.44 , 95 % CI 0.32-0 .62 ) , and the Q-ITT population ( HR 0.45 , 95 % CI 0.34-0 .61 ) .