There was no statistically significant difference between the MNTX and placebo groups for the median ( IQR ) pruritus AUC scores [ 24 ( 9-47 ) vs 36 ( 11-68 ) , median difference 8.5 , 95 % confidence interval ( CI ) 0-20 , P = 0.09 ] or the worst pruritus score [ 3 ( 2-7 ) vs 5 ( 2-6 ) , median difference 1 , 95 % CI 0-2 , P = 0.24 ] .