Regarding the effects of smoking on the antiplatelet effects of DAT or TAT , post-treatment platelet reactivity ( in P2Y12 reaction units ; PRU ) in current smokers was not significantly lower than that in non-smokers in the DAT group , whereas , in the TAT group , it was significantly lower than that of non-smokers ( 18988 vs. 21689 PRU , P = 0.01 ) .