The primary composite end point , good HIV disease control , was defined as survival with no new World Health Organization stage 4 events , a CD4 + count of more than 250 cells per cubic millimeter , and a viral load of less than 10,000 copies per milliliter or 10,000 copies or more with no protease resistance mutations at week 96 and was analyzed with the use of imputation of data ( 4 % ) .