For these categories , the multifactorially adjusted hazard ratio was 1.99 ( 95 % confidence interval , 1.49-2 .67 ) for ischemic stroke , 1.85 ( 1.44-2 .37 ) for ischemic cerebrovascular disease , 1.28 ( 0.95-1 .73 ) for myocardial infarction , and 1.23 ( 1.01-1 .51 ) for ischemic heart disease .