TXA patients were older ( median age , 37 years vs. 32 years ) , were more severely injured ( median ISS , 29 vs. 14 ) , had a lower blood pressure ( median systolic blood pressure 103 mm Hg vs. 125 mm Hg ) , and were more likely to be in shock ( median , base excess , -5 mmol/dL vs. -2 mmol/dL ) , all p < 0.05 .