Treatment with simeprevir , peginterferon alfa 2a , and ribavirin was superior to placebo , peginterferon alfa 2a , and ribavirin ( SVR12 in 210 [ 80 % ] patients of 264 vs 65 [ 50 % ] of 130 , respectively , adjusted difference 293 % [ 95 % CI 201-386 ; p < 00001 ) .