Compared with 3 week dosing , chemotherapy every 2 weeks was associated with increased rate of grade 3-4 of anaemia ( 14 [ 14 % ] of 988 patients vs two [ 02 % ] of 984 patients ; p = 0002 ) ; transaminitis ( 19 [ 19 % ] vs four [ 04 % ] ; p = 0001 ) , and myalgias ( 31 [ 31 % ] vs 16 [ 16 % ] ; p = 0019 ) , and decreased rates of grade 3-4 neutropenia ( 147 [ 149 % ] vs 433 [ 440 % ] ; p < 00001 ) .