In total , the mean platelet reactivity and the total number of nonresponders ( PRU 230 ) with clopidogrel did not change between 2 periods for the 75-mg ( 22.4 % vs. 21.9 % ; p = 0.86 ) and 150-mg doses of clopidogrel ( 11.5 % vs. 11.5 % ; p = 1.00 ) .