A reduction in independence was predicted by tissue hypoattenuation ( odds ratio 066 , 95 % CI 055-081 ) , large lesion ( 051 , 038-068 ) , swelling ( 059 , 046-075 ) , hyperattenuated artery ( 059 , 047-075 ) , atrophy ( 074 , 059-094 ) , and leukoaraiosis ( 072 , 059-087 ) .