Rikkunshito was relatively more effective among Helicobacter pylori-infected participants ( rikkunshito : 40.0 % vs placebo : 20.5 % , p = 0.07 ) , and seemed less effective among H. pylori-uninfected participants ( rikkunshito : 29.3 % vs placebo : 25.6 % , p = 0.72 ) .