Regarding the secondary end-points , PDT plus S-1 was associated with prolonged progression-free survival compared with PDT alone ( median 10 months [ 95 % CI : 4.1-16 ] versus 2 months [ 95 % CI : 0.4-3 .5 ] , P = 0.009 ( HR for progression 0.39 , 95 % CI : 0.19-0 .83 ) .