Supplementation with 5mg/d folate resulted in reduced plasma Hcy ( -223 vs -186 and 116m , respectively , P < 005 ) , HOMA-B ( -763 vs 143 and 1366 , respectively , P < 005 ) , serum hs-CRP ( -2122 vs -2624 and 7298g/l , respectively , P < 005 ) and plasma MDA concentrations ( -048 vs -024 and 069m , respectively , P < 001 ) compared with folate-1 and placebo groups .