We used the database of a randomized trial comparing radiation treatment dose fractionation schedules to evaluate whether response , determined using the International Consensus Endpoint ( ICE ) and Brief Pain Inventory pain score ( BPI-PS ) , is associated with patient perception of benefit , as measured using the European Organisation for Resesarch and Treatment of Cancer ( EORTC ) Quality of Life Questionnaire Core 30 ( QLQ-C30 ) and functional interference scale of the BPI ( BPI-FI ) .