Based on a 6-month DS paradigm , early-start patients ( n = 19 ) compared to DS patients ( n = 18 ) ( 37/40 completed ) responded significantly earlier and sustainably to treatment in both substantia nigra iron deposits ( R2 * MRI ) and Unified Parkinson 's Disease Rating Scale motor indicators of disease progression ( p < 0.03 and p < 0.04 , respectively ) .