After two years , a significant increase was found in the physical health composite score ( = +3.1 in group a , = +3 in group b , p < 0.05 in both ) , mental health composite score ( = +4.7 in group a , = +5.5 in group b , p < 0.001 in both ) , in eight MSQoL sub-items of group a and in seven sub-items in group b. Conversely , the untreated group showed a slight decrease in seven domains .