The average dose during the second year of the randomised trial did not differ between the IGF1 titration group ( 38g/kg per day , s.d. 0.019 ) and the low-dose group ( 35g/kg per day , s.d. 0.002 ; P = 0.46 ) , but there was a wide variation in the IGF1 titration group ( range 10-80g / kg per day ) .