In the 53 patients not receiving catecholamines at blood sampling , endogenous p-noradrenaline correlated positively with adrenaline , syndecan 1 , soluble vascular endothelial growth factor receptor 1 , soluble CD40 ligand , tissue-type plasminogen activator , and plasminogen activator inhibitor 1 ( PAI-1 ) and negatively with PAI-1 / tissue-type plasminogen activator ratio ( all P < .05 ) and was independently associated with syndecan 1 , soluble vascular endothelial growth factor receptor 1 , and PAI-1 ( all P < .05 ) , and 28 - and 90-day mortality ( P < .05 ) .