On the basis of age ( median , 60 years ; range , 17 to 85 years ) , performance status , WBC count , and mutation status of NPM1 , CEBPA , and FLT3-internal tandem duplication , patients were classified into the following three risk groups according to PINAOS and PINARFS : 29 % of all patients and 32 % of 381 responding patients had low-risk disease ( 5-year OS , 74 % ; 5-year RFS , 55 % ) ; 56 % of all patients and 39 % of responding patients had intermediate-risk disease ( 5-year OS , 28 % ; 5-year RFS , 27 % ) , and 15 % of all patients and 29 % of responding patients had high-risk disease ( 5-year OS , 3 % ; 5-year RFS , 5 % ) , respectively .