Bedaquiline reduced the median time to culture conversion , as compared with placebo , from 125 days to 83 days ( hazard ratio in the bedaquiline group , 2.44 ; 95 % confidence interval , 1.57 to 3.80 ; P < 0.001 by Cox regression analysis ) and increased the rate of culture conversion at 24 weeks ( 79 % vs. 58 % , P = 0.008 ) and at 120 weeks ( 62 % vs. 44 % , P = 0.04 ) .