Compared to the control group , the availability of interactive sections significantly increased patient empowerment ( midterm assessment : mean difference = +1.2 , P = .03 , d = 0.63 ; final assessment : mean difference = +0.8 , P = .09 , d = 0.44 ) and reduced medication misuse ( midterm assessment : mean difference = -1.5 , P = .04 , d = 0.28 ; final assessment : mean difference = -1.6 , P = .03 , d = -0.55 ) in the intervention group .