Although glycated hemoglobin did not track with insulin sensitivity , Quantose M ( Q ) increased in pioglitazone-treated subjects ( by 1.45 [ 3.45 ] mgmin ( -1 ) kgwbm ( -1 ) ) ( median [ interquartile range ] ) ( P < .001 vs placebo ) , as did the Matsuda index ( by 3.05 [ 4.77 ] units ; P < .0001 ) .