There was a trend toward a reduction ( P = 0.07 ) in the total number of infections in the active group , which was significant when confirmed by one of the investigators ( 268/388 [ 69 % ] vs 293/379 [ 77 % ] , respectively , relative risk 0.89 , 95 % CI 0.82-0 .97 ; P = 0.004 , post hoc ) .