C-peptide incremental area under the curve ( AUC ) decreased by 10,208 120 pmol/l min for 6 h from pre to post Fr + active intervention ( P = 0.02 ) leading to a decrease in plasma insulin total AUC ( pre : 58,470.26261.0 pmol/l ; post : 49,444.33883.0 pmol/l ; P = 0.04 ) resulting in a decrease peak [ Insulin ] ( P = 0.009 ) .