The mean change from baseline BCVA was also significantly higher in the IAI 2Q4 + PRN group compared with the sham + IAI PRN group at week 24 ( +17.3 vs. -4.0 letters ; P < 0.001 ) , week 52 ( +16.2 vs. +3.8 letters ; P < 0.001 ) , and week 100 ( +13.0 vs. +1.5 letters ; P < 0.0001 ) .