In multivariate analysis evaluating renal events requiring treatment modification , only baseline HIV-1 RNA and creatinine clearance were significantly associated ( OR 4.41 , 95 % CI 1.65 , 11.78 per 1 log10 copies/ml higher ; P = 0.003 and OR 0.80 , 95 % CI 0.64 , 0.99 per 10 ml/min higher ; P = 0.040 , respectively ) .