Platelet activation ( - thromboglobulin [ - TG ] ) and thrombin generation ( prothrombin fragment 1 + 2 [ F1 +2 ] , thrombin-antithrombin complex [ TAT ] ) were studied in an open-label , randomized , parallel group trial in 60 healthy male subjects ( n = 20 per group ) who received ticagrelor and acetylsalicylic acid ( ASA ) in combination with dabigatran ( 150 mg bid ) , rivaroxaban ( 20 mg od ) or phenprocoumon ( INR 2.0-3 .0 ) .