Compared with SC , the NI group had a significantly higher EORTC global QoL score at the first mid-study follow-up ( coefficient ( 95 % CI ) 21.0 ( 12.1 , 29.9 ) adjusted for baseline , p < 0.001 ) and at 26 weeks ( 28.4 ( 21.3 , 35.4 ) adjusted for baseline , p < 0.001 ) .