During the hypoglycemic clamp , glucagon responses were markedly diminished ( 16.0 4.2 vs. 48.6 6.0 ng/L , P < 0.05 ) , but other hormonal responses and the decrement in the required exogenous glucose infusion rate ( GIR ) from the euglycemic clamp were normal ( -10.4 1.1 vs. -7.8 1.9 mol kg ( -1 ) min ( -1 ) in control subjects ) ; however , endogenous glucose production ( EGP ) did not increase ( -0.8 1.0 vs. 2.2 0.7 mol kg ( -1 ) min ( -1 ) in control subjects , P < 0.05 ) , whereas systemic glucose disposal decreased normally .