Time to progression with OFF ( 2.9 months ; 95 % CI , 2.4 to 3.2 ) versus FF ( 2.0 months ; 95 % CI , 1.6 to 2.3 ) was significantly extended also ( HR , 0.68 ; 95 % CI , 0.50 to 0.94 ; log-rank P = .019 ) .