Furthermore , the recurrent rate was higher in negative control ( placebo ) group ( 47.3 % ) than that in positive control group ACV ( 26.7 % ) and test GCV group ( 17.2 % ) , and there was a great significant difference among the three groups ( P = 0.007 ) , but there was no significant difference between positive control ACV group and test GCV group ( P = 0.358 ) .