The time to 70 % temperature recovery ( middle finger probe ) was longer with active than placebo treatment : mean ( s.d. ) values for placebo , 30 mg of ORM-12741 and 100 mg of ORM-12741 were 21.4 min ( 12.4 ) , 25.7 min ( 12.2 ) and 26.9 min ( 13.9 ) , respectively .