Patients with pre-stent TIMI 3 flow had significantly lower IS ( 15.5 % [ 4.6 , 21.8 ] vs. 22.6 % [ 14.7 , 28.0 ] for TIMI 2 vs. 19.5 [ 14.4 , 27.8 ] for TIMI 0/1 , p < 0.0001 ) and fewer 30-day clinical events ( p = 0.03 ) .