Compared to placebo patients with mixed episodes , asenapine treatment provided significant improvements ( p < 0.05 ) in Bodily Pain ( asenapine = 50.9 , placebo = 45.9 ) , Social Functioning ( asenapine = 44.1 , placebo = 39.6 ) and Mental Health ( asenapine = 46.6 , placebo = 42.7 ) by Week 3 ; by comparison , olanzapine treatment did not lead to significant improvements in any domain of HRQoL compared to placebo .