There was some evidence of a differential effect ( nominal interaction p = .008 ) for a prespecified comparison : Intensive lifestyle intervention was associated with a relative mean benefit for composite cognitive function of 0.276 ( 95 % confidence interval : 0.033 , 0.520 ) SDs among individuals with body mass index less than 30 kg/m ( 2 ) at baseline compared with a relative mean deficit of 0.086 ( -0.021 , 0.194 ) SDs among individuals with body mass more than or equal to 30 kg/m ( 2 ) .