At month 3 , LGH increased clamp glucose infusion rates ( P < .01 ) and IGF-1 to IGFBP-3 molar ratio ( P < .05 ) , but fasting glucose , insulin , C-peptide , free fatty acid , adiponectin , IGF-1 bioactivity , IGF-2 , IGFBP-2 , 24-hour CPRs , adipocyte size , adipocyte 11-hydroxysteroid dehydrogenase activity , intrahepatic lipid , extramyocellular , or intramyocellular were unchanged .