ORRs were 13 % [ 95 % confidence interval ( CI ) 6 % -24 % ] and 17 % ( 95 % CI 8 % -29 % ) , and disease control rates were 48 % ( 95 % CI 35 % -61 % ) and 63 % ( 95 % CI 50 % -75 % ) for the 21 - and 28-day regimens , respectively .