In the low-fat group , as compared to the G allele , the A allele tended to be related to the decrease in TC and LDL cholesterol concentrations [ TC ( SE ) : -5.5 3.0 , P = 0.07 ; LDL cholesterol : -4.8 2.5 , P = 0.06 ] and a lower increase in HDL cholesterol concentrations ( SE : -1.37 0.69 , P = 0.048 ) , whereas an opposite effect in the high-fat diet group was evident [ TC ( SE ) : 7.3 2.7 , P = 0.008 ; LDL cholesterol : 4.1 2.3 , P = 0.07 ] , and there was no genetic effect on changes in HDL cholesterol concentrations ( P = 0.54 ) .