9333 local ( ie , patch-site ) adverse events ( including erythema , rash , pruritus , hyperpigmentation , pain , hypopigmentation , and oedema ) occurred in 943 ( 93 % ) of 1015 participants in the LT-patch group , compared with 1444 local adverse events in 574 ( 56 % ) of 1019 participants in the placebo group ( p < 0.0001 ) .