GH dosing titrated to an IGF-I target of 0 SDS was the most dose-sparing treatment regimen for GHD or ISS children ( meanSE HSDS/GH dose ratios 481 44 and 325 28 , respectively ) compared with conventional dosing ( 303 66 and 213 35 , respectively ; P = 002 , P = 0005 ) and IGF2T ( 327 48 and 163 28 , respectively ; P = 002 , P < 00001 ) .