Forty-eight healthy adults aged 18-45 years were randomized into 4 cohorts of 12 to receive three vaccine doses ( day 0 , 28 and 84 ) of 10 ( 9 ) , 10 ( 10 ) , 5X10 ( 10 ) , 10 ( 11 ) vp of Ad35.CS .01 or normal saline by intra muscular injection .