Pooled analyses of computed tomographic substudies in the pilot phase ( INTERACT1 ) and main phase ( INTERACT2 ) , both international , prospective , open , blinded end point , randomized controlled trials , of patients with spontaneous intracerebral hemorrhage ( < 6 hours ) and elevated systolic blood pressure , randomly assigned to intensive ( target systolic blood pressure , < 140 mm Hg ) or guideline-based ( systolic blood pressure , < 180 mm Hg ) blood-pressure management .