In the case of EtOH , the area under the concentration-time curve from 0 to 4 hours ( AUC0-4 ) and the peak blood concentration of EtOH ( Cmax ) in subjects with ADH1B * 2 / * 2 were significantly higher than those in subjects with ADH1B * 1 / * 2 at all 3 dosages before stratifying by ALDH2 genotype .