Blood samples were harvested on the morning of the 2nd admission day ( TO ) , immediately after operation ( T1 ) , on the morning of the 3rd day after operation ( T3 ) , and on the morning of the 5th day after operation ( T4 ) to detect prothrombin time ( PT ) , thrombin time ( TT ) , activated partial thromboplastin time ( APTT ) , levels of FIB and D-dimer ( D-D ) , changes of white blood cell ( WBC ) , neutrophils ( N ) , C-reactive protein ( CRP ) , erythrocyte sedimentation rate ( ESR ) , and IL-6 .