On day 7 , 27/30 ( 90 % ) patients who received imiquimod and intradermal TIV achieved seroconversion against the H1N1 strain by HI , compared with 4/30 ( 13.3 % ) who received aqueous-cream and intramuscular TIV ( P < .001 ) , and 12/31 ( 38.7 % ) who received aqueous-cream and intradermal TIV ( P < .001 ) .