Administration of nemonoxacin concomitantly with ferrous sulfate markedly decreased AUC0 - by 63.7 % , Cmax by 57.0 % , and Ae by 59.7 % , while concomitant administration of nemonoxacin with calcium carbonate mildly decreased AUC0 - by 17.8 % , Cmax by 14.3 % , and Ae by 18.4 % .