The Symbol Digit Modalities Test scores improved in all groups at 12 month vs. baseline ( Avonex : 34.50 vs. 38.95 , p = 0.011 ; Rebif : 35.30 vs. 40.13 , p = 0.001 ; Betaferon : 26.18 vs. 29.32 , p = 0.029 ) .