In the overall population ( n = 66 ) , the objective response rate ( ORR ) was 27.3 % ( all PR ; 95 % CI : 17.0-39 .6 ) , with a disease control rate ( DCR ) of 57.6 % ( 95 % CI : 44.8-69 .7 ) , a median time to progression ( TTP ) of 4.8 months ( n = 58 ; 95 % CI : 3.4-5 .9 ) and a median overall survival ( OS ) of 11.5 months ( 95 % CI : 7.9-13 .6 ) .