In the crossover phase ( n = 28 ) , least squares mean changes in the UPDRS part III score from pre-dose were -24.5 points with apomorphine and -2.3 points with placebo , showing that apomorphine , compared with placebo , provided a significantly greater improvement in the UPDRS part III score change ( difference between treatments : -22.1 [ 95 % confidence interval , -27.8 , -16.4 ] ; P < 0.001 ) .