Patients were randomized into 3 groups to receive different regimens of antioxidant therapy as an adjunct to standard therapy : control group ( ascorbic acid ; 132 patients ) ; cytoflavin ( 20 ml per day for 10 days ; 133 patients ) ; cytoflavin ( the dose was decreased to 10 ml per day from 11th to 20th day ) ( 108 patients ) .