PANSS total score improvement at Week 6 was statistically significant versus placebo for cariprazine 1.5 mg/d , 3.0 mg/d , and 4.5 mg/d ( least squares mean difference [ LSMD ] : -7.6 , -8.8 , -10.4 , respectively ; p < 0.001 ; LOCF ) and risperidone ( -15.1 , p < 0.001 ; LOCF ) ; significant improvement on CGI-S was demonstrated for all active treatments ( p < 0.05 ) .