The median overall survival in the OFF group ( 5.9 months ; 95 % CI , 4.1 to 7.4 ) versus the FF group ( 3.3 months ; 95 % CI , 2.7 to 4.0 ) was significantly improved ( hazard ratio [ HR ] , 0.66 ; 95 % CI , 0.48 to 0.91 ; log-rank P = .010 ) .