In an intention-to-treat analysis , the proportion of patients reaching the ACR50 response criteria was 46.4 % ( 32/69 ) , 55.1 % ( 38/69 ) and 76.8 % ( 53/69 ) , respectively , in the MTX , TwHF and MTX+T wHF groups ( TwHF vs MTX monotherapy , p = 0.014 ; MTX+T wHF vs MTX monotherapy , p < 0.001 ) .