ACT-246475 C max and AUC0 - ratios of geometric means ( 90 % CI ) using F1 as reference , for F2 were 8.5 ( 5.42 , 13.35 ) and 3.4 ( 2.40 , 4.82 ) , respectively , and for dF 2.2 ( 1.42 , 3.49 ) and 1.5 ( 1.07 , 2.16 ) , respectively .