When using the combined criteria for cure , 10/26 ( 38 % ) macroadenomas were cured in the pretreatment group compared with 6/25 ( 24 % ) in the direct surgery group 1 year postoperatively ( P = 0.27 ) , and 9/22 ( 41 % ) vs 6/22 ( 27 % ) macroadenomas , respectively , 5 years postoperatively ( P = 0.34 ) .