The results of Generalised Estimating Equations test followed by pairwise contrasts tests indicated that the participants who received CS showed significantly greater reduction of symptoms ( mean difference of CS vs. placebo = 26.13-34 .55 , P < 0.0005 ) and improvements in quality of life ( mean difference of CS vs. placebo = 12.81-16 .76 , P < 0.001 ) , and body constitution in ` Qi-deficiency ' , ` Yang-deficiency ' , and ` Inherited Special ' ( mean difference of CS vs. placebo = 7.05-8 .12 , 7.56-8 .92 , and 4.48-8 .10 , P = 0.01 - < 0.0005 , 0.001-0 .004 , and 0.01 - < 0.0005 , accordingly , at three post-tests ) .