In a full analysis set , increases in the total exercise duration ( TED ) were 54.3120.1 seconds with Iva 5mg and 58.8114.7 seconds with Aten 12.5 mg at the fourth week , and at the 12th week , TED improved by 84.1130.5 seconds with Iva and 77.8126.6 seconds with Aten ( 95 % CI : -21.4 -34.1 seconds , p = 0.0011 for noninferiority ) .