The mean cumulative ICP burden ( 15.52 % [ HTS ] vs 36.5 % [ mannitol ] ; p = 0.003 ) and the mean ( SD ) daily ICP burden ( 0.3 0.6 hours/day [ HTS ] vs 1.3 1.3 hours/day [ mannitol ] ; p = 0.001 ) were significantly lower in the HTS group .