The intention-to-treat and per-protocol eradication rates were significantly higher in the BOTMO group ( 86.5 % , 95 % CI : 0.85-0 .87 and 86.7 % , 95 % CI : 0.80-0 .89 , respectively ) compared with the BOACT group ( 75.5 % , 95 % CI : 0.73-0 .76 and 76 % , 95 % CI : 0.69-0 .80 , respectively ) ( P < 0.05 ) .