Mean SE TOTPAR-8 scores were 10.8 1.4 ( indomethacin submicron particle capsules 20 mg ) , 12.6 1.3 ( indomethacin submicron particle capsules 40 mg ) , 14.8 1.3 ( celecoxib ) , and 3.0 1.3 ( placebo ; P < 0.001 for active treatments vs. placebo ) .