In manipulation group , there were 9 males and 11 females aged from 58 to 74 years old with an average of ( 66.637.73 ) , the courses of diseases ranged from 3 to 8 months with an average of ( 5.652.58 ) , spinal leveraging manipulation ( following meridian to straighten tendon , relieving spasm , osteopathy and massage , clearing and activating the channels and collaterals ) were performed for 30 min , once a day , 4 days for a period treatment , totally 9 courses .