There were no statistically significant between-group differences in changes in cartilage loss , synovitis or effusion at the follow-up ( analysis of covariance ; ANCOVA , P > 0.16 ) , while there was an increased number of medial tibiofemoral BMLs in the exercise group ( ANCOVA , P = 0.015 ) compared to both diet ( difference : -0.21 [ 95 % CI -0.40 : -0.03 ] ) and `` no attention '' ( difference : -0.26 [ 95 % CI -0.44 : -0.07 ] ) groups .