Serelaxin induced a similar dyspnoea relief in HFpEF vs. HFrEF patients by visual analogue scale-area under the curve ( VAS-AUC ) through Day 5 [ mean change , 461 ( -195 , 1117 ) vs. 397 ( 10 , 783 ) mm h , P = 0.87 ] , but had possibly different effects on the proportion of patients with moderately or markedly dyspnoea improvement by Likert scale at 6 , 12 , and 24 h [ odds ratio for favourable response , 1.70 ( 0.98 , 2.95 ) vs. 0.85 ( 0.62 , 1.15 ) , interaction P = 0.030 ] .