Day 28 change from baseline ( mean ( SD ) ) : fasting insulin ( mmoll ( -1 ) ) = 1.0 ( 51.66 ) , 8.9 ( 95.04 ) , -6.9 ( 41.45 ) , 4.1 ( 57.16 ) and 15.2 ( 138.79 ) for placebo , 0.25 g , 0.5 g , 1.0 g and 2.0 g , respectively ) Treatment with SRT2104 was associated with improvement in lipid profiles .