Following evaluation of the maximum tolerated dose , SERT occupancy was determined by applying [ ( 11 ) C ] DASB positron emission tomography ( PET ) after single-dose BMS-820836 ( 0.5 or 3 mg ; n = 3 each ) and DAT occupancy by applying [ ( 11 ) C ] PE2I PET after single-dose BMS-820836 ( 3 mg ; n = 6 ) .