During long-term , NT-proBNP-guided therapy did not improve hospital-free ( primary end point : hazard ratio , 0.87 ; 95 % confidence interval , 0.71-1 .06 ; P = 0.16 ) or overall survival ( hazard ratio , 0.85 ; 95 % confidence interval , 0.64-1 .13 ; P = 0.25 ) but did improve HF hospitalization-free survival ( hazard ratio , 0.70 ; 95 % confidence interval , 0.55-0 .90 ; P = 0.005 ) .