Participants ( 18-55 years , 10 cigarettes/day within 1 hr of waking , expired carbon monoxide > 10 ppm on screening ) received single doses of nicotine on consecutive days ( 0.45 and 0.67 mg [ Part B ] and 0.45 mg [ Part D ] via the novel device ; 10 mg via Nicorette [ Parts B and D ] ) .