Regarding the two levels of the two examined factors for aconite cake-separated moxibustion , after the first course of treatment , the changes in HAMA scores were significantly different for the two tested moxibustion frequencies ( P = 0.011 ) , with greater changes for the `` 6 treatments/wk '' groups than for the `` 3 treatments/wk '' groups ; in addition , there were interaction effects between the number of cones and moxibustion frequency ( P = 0.028 ) .