Objective response rates are as follows : mutation-positive tumor , 70 % ( 95 % CI , 60.5-77 .7 ) ; mutation-positive tumor and plasma 1 , 76.9 % ( 95 % CI , 65.4-85 .5 ) ; and mutation-positive tumor and mutation-negative plasma 1 , 59.5 % ( 95 % CI , 43.5-73 .7 ) .