During stair ascent and descent , lateral wedge insoles significantly ( P < 0.05 ) reduced the 1st peak external knee adduction moment in early stance ( ascent 6.8 % , descent 8.4 % ) , the trough in mid stance ( ascent 13 % , descent 10.7 % ) , 2nd peak in the late stance ( ascent 15 % , descent 8.3 % ) and the knee adduction angular impulse compared to the control ( standard shoe ) with large effect sizes ( 0.75-0 .95 ) .