Baseline and annual echocardiograms were recorded in 873 hypertensive patients with electrocardiographic signs of LV hypertrophy during 4.8 years randomized losartan - or atenolol-based antihypertensive treatment in the Losartan Intervention For Endpoint ( LIFE ) reduction in hypertension study and classified as having ISH ( n = 128 ) if systolic BP 160 mmHg and diastolic BP < 90 mmHg , or non-ISH divided into two groups by systolic BP 160 mmHg ( non-ISH 160 mmHg ) ( n = 645 ) and systolic BP < 160 mm Hg ( n = 100 ) ( non-ISH < 160 mmHg ) , respectively .