Treatment with QMF149 resulted in no significant difference in time to first serious exacerbation compared to MF ( 2 ( 0.3 % ) vs 6 events ( 0.8 % ) ; difference -0.52 percentage point ; 95 % CI -1.25 to 0.21 , p = 0.160 , HR = 0.31 ; 95 % CI 0.06 to 1.54 , p = 0.151 ) .