Between Nov 29 , 2010 , and Sept 13 , 2012 , we enrolled 1106 eligible adult patients with chronic plaque psoriasis and randomly assigned them to the four treatment groups ( 330 to tofacitinib 5 mg twice daily , 332 to tofacitinib 10 mg twice daily , 336 to etanercept 50 mg twice weekly , and 108 to placebo ) .