For rifampin study , 12 patients were randomized ( 1:1 ) to sequence of a cycle of trabectedin ( 1.3 mg/m ( 2 ) , 3 h , i.v. ) coadministered with rifampin ( 600 mg/day , 6-days ) , and a cycle of trabectedin monotherapy ( 1.3 mg/m ( 2 ) , 3 h , i.v. ) .