In this study , we sought to examine the hypothesis that neoadjuvant chemotherapy ( NAC ) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy ( LRH ) on patients with cervical cancer and to elucidate the potential roles of the p53 : miR-34a : E2F1 and the p53 : miR-605 : Mdm2 signaling pathways in this therapy .