The factors related to adherence when multifactorial intervention was applied were the number of exacerbations ( OR = 0.66 ) , visits to health centre ( OR = 0.93 ) and devices ( OR = 2.4 ) ; illness severity ( OR = 0.67 ) , beta-2-adrenergic ( OR = 0.16 ) and xantine ( OR = 0.19 ) treatment ; activity ( OR = 1.03 ) and impact ( OR = 1.03 ) scales of the Saint George Respiratory Questionnaire .