In the case of acetaldehyde , the AUC0-4 and Cmax of acetaldehyde of ADH1B * 2 / * 2 after administration of 0.25 g/kg alcohol and the AUC0-4 of acetaldehyde of ADH1B * 2 / * 2 at 0.5 g/kg were significantly higher than corresponding values of ADH1B * 1 / * 2 only in the group of ALDH2 * 1 / * 2 .