For cumulative opioid use , the hazard ratios ( HRs ) for dementia were 1.06 ( 95 % confidence interval ( CI ) = 0.88-1 .26 ) for 11 to 30 TSDs , 0.88 ( 95 % CI = 0.70-1 .09 ) for 31 to 90 TSDs , and 1.29 ( 95 % CI = 1.02-1 .62 ) for 91 or more TSDs , versus 0 to 10 TSDs .