The Cancer and Leukemia Group B 30504 trial was a randomized , placebo-controlled , phase II study that enrolled patients before chemotherapy ( cisplatin 80 mg/m ( 2 ) or carboplatin area under the curve of 5 on day 1 plus etoposide 100 mg/m ( 2 ) per day on days 1 to 3 every 21 days for four to six cycles ) .