Rosuvastatin at 10 mg/d ( R10 ) and 40 mg/d ( R40 ) significantly ( all P < .001 unless stated otherwise ) lowered plasma cholesterol ( -34 % and -42 % [ % change with R10 and with R40 , respectively ] ) , low-density lipoprotein cholesterol ( -49 % and -57 % ) and triglyceride ( -24 % , P = .03 and -42 % ) concentrations .