Composite mean Female Sexual Function Index change from baseline to week 8 was 1.4 ( 95 % confidence interval [ CI ] -0.4 to 3.2 ) for estradiol , 1.1 ( 95 % CI -0.5 to 2.7 ) for venlafaxine , and -0.3 ( 95 % CI -1.6 to 1.0 ) for placebo .