GMTs were statistically significantly lower for an HPV-16 / 18/31/45 AS04 vaccine containing 20/20/10 / 10 g VLPs for both anti-HPV-16 and anti-HPV-18 antibodies , and for an HPV-16 / 18/33/58 AS04 vaccine containing 20/20/20 / 20 g VLPs for anti-HPV-16 antibodies .