A significant interaction ( P = 0.004 ) suggests a lower coronary heart disease risk in the obese for lisinopril versus chlorthalidone ( hazard ratio 0.85 , 95 % confidence interval 0.74-0 .98 ) and a significant interaction ( P = 0.011 ) suggests a higher risk of end-stage renal disease for amlodipine versus chlorthalidone in obese participants ( hazard ratio 1.49 , 95 % confidence interval 1.06-2 .08 ) .