There was a significant decline in the mean viral loads of HPV-6 ( from 0.011108 to 0.00000154108 copies/mg of tissue ; P = .003 ) and HPV-11 ( from 0.121108 to 0.017108 copies/mg of tissue ; P = .03 ) after treatment in the Mw group but only in the viral load of HPV-6 ( from 1.41108 to 0.004108 copies/mg of tissue ; P = .01 ) in the imiquimod group .