On a continuous scale , baseline ALT and AST were associated with 180-day mortality ( hazard ratios [ HRs ; per doubling ] 1.52 [ P = .030 ] and 1.97 [ P = .013 ] , respectively ) and worsening HF through day 5 ( HRs [ per doubling ] 1.72 [ P = .005 ] and 1.95 [ P = .008 ] , respectively ) .