The composite fingernail score improved with the Early and Monthly regimens , but worsened with placebo [ percentage mean change from baseline ( SE ) : -19.1 % ( 6.12 ) and -10.6 % ( 7.06 ) vs. 14.4 % ( 11.92 ) ; P = 0.010 vs. placebo for Early , P = 0.027 for Monthly ) .