Patients with abnormal MPS had more MACE ( 9.8 % ; hazard ratio : 3.44 ; 95 % confidence interval [ CI ] : 1.32 to 8.95 ; p = 0.011 ) and ischemia or new scar ( 34.2 % ; odds ratio : 15.91 ; 95 % CI : 7.24 to 38.03 ; p < 0.001 ) despite therapy , resulting in `` overt or silent CAD progression '' of 35.6 % versus 4.6 % ( odds ratio : 11.53 ; 95 % CI : 5.63 to 24.70 ; p < 0.001 ) .