Proctitis symptoms were highest scored in the placebo group in both the second ( 19.5 [ 16-25 ] ) and third ( 19 [ 17-24 ] ) weeks than in the synbiotic group ( week 2 : 16.5 [ 15-20 ] , P < .05 ; week 3 : 17 [ 15-23 ] , P < .01 ) .