The authors conducted a randomized trial in patients with TNM stage I to III breast cancer comparing standard care with SIS.NET ( System for Individualized Survivorship Care , based on patient self-reported data , with review by Nurse practitioners , targeted Education , and Triage ) , a follow-up protocol including integration of online health questionnaires at 3-month intervals and the evaluation of self-reported symptoms monitored and addressed remotely by a nurse practitioner ( NP ) .