Weight loss was 6.0 % ( 6.4 kg ) with liraglutide ( 3.0-mg dose ) , 4.7 % ( 5.0 kg ) with liraglutide ( 1.8-mg dose ) , and 2.0 % ( 2.2 kg ) with placebo ( estimated difference for liraglutide [ 3.0 mg ] vs placebo , -4.00 % [ 95 % CI , -5.10 % to -2.90 % ] ; liraglutide [ 1.8 mg ] vs placebo , -2.71 % [ 95 % CI , -4.00 % to -1.42 % ] ; P < .001 for both ) .