The primary end-point ( treatment failure ) occurred in 13.3 % ( 12/90 ) of the low-dose cyclosporine group and 16.7 % ( 15/90 ) of the standard-dose cyclosporine group ( p = 0.53 ) ( difference -3.4 % , 95 % confidence interval -11.7 % to 7.5 % , based on a noninferiority margin of 20 % ) .