After using the noninferiority test , the mean difference ( 95 % confidence interval ) of WOMAC total , WOMAC pain , and WOMAC function scores at week 4 adjusted by values at week 0 of C. domestica extracts were noninferior to those for the ibuprofen group ( P = 0.010 , P = 0.018 , and P = 0.010 , respectively ) , except for the WOMAC stiffness subscale , which showed a trend toward significance ( P = 0.060 ) .