Across all dosing regimens , the most common adverse events were diarrhoea ( 83 patients , 64 % ) , non-acneiform rash ( 77 patients , 60 % ) , liver enzyme abnormalities ( 64 patients , 50 % ) , fatigue ( 62 patients , 48 % ) , nausea ( 58 patients , 45 % ) , and photosensitivity ( 52 patients , 40 % ) .