Grades 3/4 drug-related toxicities ( in 5 % of patients ) in pemetrexed/pemetrexed + erlotinib were febrile neutropenia ( 2.4 % / 10.5 % ) , diarrhoea ( 1.2 % / 5.3 % ) , rash ( 1.2 % / 9.2 % ) ; anaemia ( 6 % / 11.8 % ) , leukopenia ( 9.6 % / 23.7 % ) , neutropenia ( 9.6 % / 25.0 % ) , and thrombocytopenia ( 4.8 % / 14.5 % ) .