Ceftobiprole , the active moiety of ceftobiprole medocaril , is a novel broad-spectrum cephalosporin , with bactericidal activity against a wide range of gram-positive bacteria , including Staphylococcus aureus ( including methicillin-resistant strains ) and penicillin - and ceftriaxone-resistant pneumococci , and gram-negative bacteria , including Enterobacteriaceae and Pseudomonas aeruginosa .