Of all-grade adverse events that occurred in 5 % or more of patients , paraesthesia ( 61 [ 47 % ] events in 131 patients in the FOLFOX group vs three [ 2 % ] in 128 patients in the cisplatin-fluorouracil group , p < 00001 ) , sensory neuropathy ( 24 [ 18 % ] vs one [ 1 % ] , p < 00001 ) , increases in aspartate aminotransferase concentrations ( 14 [ 11 % ] vs two [ 2 % ] , p = 0002 ) , and increases in alanine aminotransferase concentrations ( 11 [ 8 % ] vs two [ 2 % ] , p = 0012 ) were more common in the FOLFOX group , whereas serum creatinine increases ( four [ 3 % ] vs 15 [ 12 % ] , p = 0007 ) , mucositis ( 35 [ 27 % ] vs 41 [ 32 % ] , p = 0011 ) , and alopecia ( two [ 2 % ] vs 12 [ 9 % ] , p = 0005 ) were more common in the fluorouracil and cisplatin group .