A double-blind , randomized , multicenter trial at 362 academic and community hospitals in Europe , Australia , New Zealand , India , and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome ( ACS ) to either varespladib ( n = 2572 ) or placebo ( n = 2573 ) with enrollment between June 1 , 2010 , and March 7 , 2012 ( study termination on March 9 , 2012 ) .