Major bleeding rate was similar between treatment groups ( 13.4 vs. 12.6 % ; HR 1.07 ; 95 % CI = 0.95-1 .19 ) , but ticagrelor was associated with an increase in non-CABG major bleeding ( 4.8 vs. 3.8 % ; HR 1.28 ; 95 % CI = 1.05-1 .56 ) .