HbA1c decreased significantly at the end of treatment in the 1 , 2.5 , 5 , and 10mg luseogliflozin groups compared with placebo ( -0.29 , -0.39 , -0.46 , and -0.43 % , respectively , versus +0.22 % ; all P < 0.001 ) , as did FPG and PPG ( all P < 0.001 ) .