Although the subdose of 587 IU is able to trigger equivalent kinetics of IL-8 / CXCL-8 and MCP-1 / CCL-2 , only the subdose of 3,013 IU is able to trigger similar kinetics of MIG/CXCL -9 , pro-inflammatory ( TNF , IFN - and IL-2 ) and modulatory cytokines ( IL-5 and IL-10 ) .