Unimproved QoL increased the probability of future MACE by 2.7 times ( 95 % confidence intervals [ CI ] : 1.26-5 .83 ; P = 0.01 ) and death by 3.2 times ( 95 % CI : 1.23-8 .32 ; P = 0.02 ) independently from clinical and echocardiographic response .