Each risk allele ( A ) of rs1558902 showed a trend to be related to a 0.05-unit less reduction in both log ( insulin ) and log ( HOMA-IR ) among the participants assigned to low-fat diets ( both P = 0.06 ) , but this was not significantly related to reduction in those assigned to high-fat diets ( both P > 0.1 ) during the 2-y period of intervention .