From weeks 4 to 8 , curcumin was significantly more effective than placebo in improving several mood-related symptoms , demonstrated by a significant group x time interaction for IDS-SR30 total score ( F1 , 53 = 4.22 , p = .045 ) and IDS-SR30 mood score ( F1 , 53 = 6.51 , p = .014 ) , and a non-significant trend for STAI trait score ( F1 , 48 = 2.86 , p = .097 ) .