The number of total T1-hypointense lesions was lower in the BCG group at months 6 , 12 , and 18 : mean changes from baseline were -0.09 0.72 vs 0.75 1.81 ( p = 0.01 ) , 0.0 0.83 vs 0.88 2.21 ( p = 0.08 ) , and -0.21 1.03 vs 1.00 2.49 ( p = 0.02 ) .