The difference between AZLI and placebo for adjusted mean change from baseline QOL-B-RSS was not significant at 4 weeks ( 0.8 [ 95 % CI -3.1 to 4.7 ] , p = 0.68 ) in AIR-BX1 , but was significant ( 4.6 [ 1.1 to 8.2 ] , p = 0.011 ) in AIR-BX2 .