Change in sedentary time was significantly and beneficially associated with changes in postprandial log-transformed plasma insulin ( = 0.002 ; 95 % CI , 0.001-0 .003 ; P = 0.001 ) , C-peptide ( = 3.7 ; 95 % CI , 1.5-6 .0 ; P = 0.001 ) , and glucose concentration ( = 0.006 ; 95 % CI , 0.002-0 .1 ; P = 0.002 ) , independent of changes in MVPA , waist circumference , and other confounders .