The objective response rate ( ORR ) and disease control rate ( DCR ) were 64.7 % ( 11/17 ) and 82.4 % ( 14/17 ) in observational group and 25.0 % ( 4/16 ) and 37.5 % ( 6/16 ) in the control group ( ORR and DCR between 2 groups , 2 = 5.2412 , P = 0.0221 and 2 = 6.9453 , P = 0.0084 ) .