Patients given E/C/F / tenofovir alafenamide had significantly smaller mean serum creatinine increases than those given E/C/F / tenofovir disoproxil fumarate ( 008 vs 012 mg/dL ; p < 00001 ) , significantly less proteinuria ( median % change -3 vs 20 ; p < 00001 ) , and a significantly smaller decrease in bone mineral density at spine ( mean % change -130 vs -286 ; p < 00001 ) and hip ( -066 vs -295 ; p < 00001 ) at 48 weeks .