To assess the interobserver agreement in 50 patients with hepatocellular carcinoma ( HCC ) before and 1 month after intra-arterial therapy ( IAT ) using two semi-automated methods and a manual approach for the following functional , volumetric and morphologic parameters : ( 1 ) apparent diffusion coefficient ( ADC ) , ( 2 ) arterial phase enhancement ( AE ) , ( 3 ) portal venous phase enhancement ( VE ) , ( 4 ) tumor volume , and assessment according to ( 5 ) the Response Evaluation Criteria in Solid Tumors ( RECIST ) , and ( 6 ) the European Association for the Study of the Liver ( EASL ) .