Patients with uncomplicated painful bone metastases were randomized ( 1:1:1 ) and blinded to receive either 8Gy in a single fraction with conventionally planned radiotherapy ( arm A ) or 8Gy in a single fraction with DPBN ( dose range between 610Gy and 10Gy ) ( arm B ) or 16Gy in a single fraction with DPBN ( dose range between 1410Gy and 18Gy ) ( arm C ) .