Change from baseline in CGI-S scores was statistically significantly greater in both cariprazine groups compared with placebo ( LSMD [ 95 % CI ] : 3-6 mg/d , -0.6 [ -0.9 to -0.4 ] ; 6-12 mg/d , -0.6 [ -0.9 to -0.3 ] ; P < .001 [ both ] ) .