After 7 , 14 , and 30 days : ( 1 ) skin sagging of the face contours was decreased by -0.443 0.286 , -1.124 0.511 , and -1.326 0.649 mm , respectively ; ( 2 ) skin sagging of the cheekbones contours was decreased by -0.989 0.585 , -2.500 0.929 , and -2.517 0.927 mm , respectively ; ( 3 ) cheekbones volume was increased by 0.875 0.519 , 2.186 0.781 , and 2.275 0.725 mm , respectively ; ( 4 ) wrinkle volume was decreased by -11.3 % , -18.4 % , and -26.3 % , respectively ; and ( 5 ) wrinkle depth was decreased by -8.4 % , -14.5 % , and -21.8 % respectively .