Adjusted mean SE changes from baseline in HbA1c were -0.50 0.05 % ( -5.5 0.5 mmol/mol ) for placebo versus -0.94 0.05 % ( -10.3 0.5 mmol/mol ) and -1.02 0.05 % ( -11.1 0.5 mmol/mol ) for empagliflozin 10 mg and empagliflozin 25 mg , respectively , at week 18 ( both P < 0.001 ) .