Compared with the placebo-treated sides , topical glycopyrrolate-treated sides showed a reduction in the rate of sweat production at the forehead of 25.16 10.30 % ( mean SD ) at 90 min after the first application ( day 1 ) , 29.63 7.74 % at 24 h after the first application ( day 2 ) and 36.68 11.41 % at 24 h after eight additional successive daily applications ( day 10 ) ( all P < 0.025 ) .