Responses were not different at 4 weeks , but greater improvement was observed at 8 weeks in the thalidomide group ( 75 % response , 13/28 [ 46.4 % ] vs 3/26 [ 11.5 % ] ; RR , 4.0 [ 95 % CI , 1.2-12 .5 ] ; NNT = 2.86 ; P = .01 ; and 25 % response , 18/28 [ 64.2 % ] vs 8/26 [ 30.8 % ] ; RR , 2.1 [ 95 % CI , 1.1-3 .9 ] ; NNT = 2.99 ; P = .01 ) .