In men , the HF F&V diet increased endothelium-dependent microvascular reactivity ( P = 0.017 ) with +2 portions/d ( at 6 wk ) and reduced C-reactive protein ( P = 0.001 ) , E-selectin ( P = 0.0005 ) , and vascular cell adhesion molecule ( P = 0.0468 ) with +4 portions/d ( at 12 wk ) .