The concentrations of vasoactive factors such as brain natriuretic peptide ( BNP , 279.07 128.17 vs. 457.67 221.30 ) , endothelin ( ET , 3.30 0.61 vs. 4.98 1.24 ) and thromboxane ( TXA2 , 97.2 24.0 vs. 163.22 24.4 ) were also significantly lower in group B than in group C ( all P < 0.05 ) .