The mean HCV RNA at start , 2 and 4 weeks of treatment were 6.69 0.70 , 1.05 0.74 , 0.22 0.48 log10 IU/ml in the TVR-2250 group and 6.70 0.62 , 1.02 0.62 , 0.13 0.41 log10 IU/ml in the TVR-1500 group .