Epidermal growth factor receptor assessed as a continuous ( logarithmic transformed ) variable shows an association with disease-free survival in Arm C ( P = 0.009 ) but not in Arm A or B. High EGFR expression was associated with worse outcome ( Hazard ratio ( HR ) = 2.15 ; 95 % CI 1.28-3 .60 , P = 0.004 ) .