Mixed-effects models revealed a significant difference between the venlafaxine XR and placebo groups in improvement on the Maier subscale from baseline to 12 weeks ( treatment effect , 1.6 ; 95 % CI , 0.3-2 .9 ; P = .02 ) but not on the HAM-D 17-item version ( treatment effect , 1.0 ; 95 % CI , -1.4 to 3.4 ; P = .42 ) .