Mothers who had the GG/GA genotype and first trimester fever had an elevated risk of NTDs ( adjusted odds ratio , 11.73 ; 95 % confidence interval , 3.02-45 .58 ) as compared to absence of maternal first trimester fever and AA genotype after adjusting for maternal education , paternal education , and age , and had a significant interactive coefficient ( = 3.17 ) between maternal GG/GA genotype and first trimester fever .