In the adjusted model , each 1-SD increase in LDL-C variability ( by ASV ) increased the risk of any coronary event by 16 % ( hazard ratio [ HR ] : 1.16 ; 95 % confidence interval [ CI ] : 1.10 to 1.23 ; p < 0.0001 ) , any cardiovascular event by 11 % ( HR : 1.11 ; 95 % CI : 1.07 to 1.15 ; p < 0.0001 ) , death by 23 % ( HR : 1.23 ; 95 % CI : 1.14 to 1.34 ; p < 0.0001 ) , myocardial infarction by 10 % ( HR : 1.10 ; 95 % CI : 1.02 to 1.19 ; p = 0.02 ) , and stroke by 17 % ( HR : 1.17 ; 95 % CI : 1.04 to 1.31 ; p = 0.01 ) , independent of treatment effect and achieved LDL-C levels .