In patients assigned to STICH Hypothesis 2 ( n = 714 ) , no genetic variant met the prespecified Bonferroni-adjusted threshold for statistical significance ( p < 0.002 ) ; however , several variants met nominal prognostic significance : variants in the 2-adrenergic receptor gene ( 2-AR Gln27Glu ) and in the A1-adenosine receptor gene ( A1-717 T/G ) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem ( p = 0.027 and 0.031 , respectively ) .