Weight loss-induced improvements in risk factors were similar among the three groups , except for a greater reduction in fasted glucose in the HT group ( difference in change [ 95 % CI ] from placebo ; -0.40 [ -0.76 , -0.05 ] ) and greater reductions in LDL ( -0.36 [ -0.63 , -0.09 ] ) and increases in HDL ( 0.15 [ 0.07 , 0.24 ] ) in both treatment groups .