In patients achieving SVR-12 ( regardless of the regimen ) , significant improvements were noted in general health ( p = 0.0004 ) , CLDQ-HCV ( p < 0.0001 ) , fatigue ( p = 0.005 ) , emotional well-being ( p < 0.0001 ) and physical component summary score of SF-36 ( p = 0.0022 ) .