From month 0 until study end , compared with 9585 episodes of clinical malaria that met the primary case definition in children in the C3C group , 6616 episodes occurred in the R3R group ( VE 363 % , 95 % CI 318-405 ) and 7396 occurred in the R3C group ( 283 % , 233-329 ) ; compared with 171 children who experienced at least one episode of severe malaria in the C3C group , 116 children experienced at least one episode of severe malaria in the R3R group ( 322 % , 137 to 469 ) and 169 in the R3C group ( 11 % , -230 to 205 ) .