Secondary outcomes include HbA1c , insulin sensitivity , lipid levels , blood pressure , serum glutathione , adiponectin , IL-6 , E-selectin , myeloperoxidase , C-reactive protein , Toll-like Receptor 4 ( TLR4 ) , soluble receptor for AGE ( sRAGE ) , urinary 8-isoprostanes , faecal bacterial composition and short chain fatty acid profile .