Fasting leptin was significantly decreased in both groups ( LoGIX : preintervention = 33.8 4.7 , postintervention = 19.2 4.5 ; HiGIX : preintervention = 27.9 4.2 , postintervention = 11.9 2.2 ngmL ; P = 0.004 ) , and HMW adiponectin was significantly increased ( LoGIX : preintervention = 1606.9 34.6 , postintervention = 3502.3 57 ; HiGIX : preintervention = 3704.8 38.1 , postintervention = 4284.3 52.8 pgmL ; P = 0.003 ) after the 12-wk intervention .