Semi-automated measurements of tumor volume and size in the axial plane before and after IAT had better interobserver agreement ( ICC = 0.854-0 .996 ) compared with manual size measurements ( ICC = 0.543-0 .596 ) , and interobserver agreement for change in tumor RECIST size was also higher using semi-automated measurements ( ICC = 0.655 ) compared with manual measurements ( ICC = 0.169 ) .