After 22 weeks , although the changes in the estimated glomerular filtration rate and blood pressure were not significant , the percent change in the serum urate level ( -45.38 vs. -0.08 % , P < 0.0001 ) and the percent change in urinary albumin-to-creatinine ratio ( -33.0 vs. -6.0 % , P = 0.0092 ) were found to have decreased in the topiroxostat as compared with the placebo .