We noted statistically significant increases between both eprotirome groups and placebo in aspartate aminotransferase ( AST ; p < 0.0001 ) , alanine aminotransferase ( ALT ; p < 0.0001 ) , conjugated bilirubin ( p = 0.0006 ) , and gamma-glutamyltranspeptidase ( p < 0.0001 ) .