In young infants , compared with 6170 episodes of clinical malaria that met the primary case definition in the C3C group , 4993 episodes occurred in the R3R group ( VE 259 % , 95 % CI 199-315 ) and 5444 occurred in the R3C group ( 183 % , 117-244 ) ; and compared with 116 infants who experienced at least one episode of severe malaria in the C3C group , 96 infants experienced at least one episode of severe malaria in the R3R group ( 173 % , 95 % CI -94 to 375 ) and 104 in the R3C group ( 103 % , -179 to 318 ) .