The changes in HbA1c ( -0.74 and -0.76 vs + 0.29 % ) , fasting plasma glucose ( 1 mg/dl = 0.0555 mmol/l ; -31.6 and -31.9 vs + 3.7 mg/dl ) , 2-h plasma glucose after 75-g glucose load ( -84.9 and -79.0 vs -0.5 mg/dl ) , body weight ( percent change : -3.76 and -4.02 vs -0.76 % ) and systolic blood pressure ( -7.88 and -6.24 vs -2.72 mmHg ) were significantly greater with 100 and 200 mg canagliflozin than with placebo ( all , p < 0.05 ) .