In multivariate analyses , taking all 4 signs as potential covariates , only rales ( hazard ratio 1.41 ; 95 % confidence interval : 1.07 to 1.86 ; p = 0.013 ) and peripheral edema ( hazard ratio : 1.25 ; 95 % confidence interval : 1.00 to 1.57 ; p = 0.048 ) were associated with cardiovascular mortality , independent of other variables .