Non-significant , but nevertheless , large effects were evident favouring the EC over time for TWS restlessness ( ( 2 ) = 0.34 ) , stress ( ( 2 ) = 0.24 ) , irritability ( ( 2 ) = 0.21 ) , tension ( ( 2 ) = 0.15 ) , and depression ( ( 2 ) = 0.14 ) .