Patients with high OTR ( defined by VerifyNow ( Accumetrics , San Diego , Calif ) assay as 230 P2Y12 reaction units [ PRU ] ) were randomly assigned in a 1:1 ratio to group 1 ( standard-dose clopidogrel therapy : 75 mg/d for 30 days ) or group 2 ( high-dose clopidogrel : 150 mg/d for 30 days ) .