Mean LDL cholesterol concentrations increased by 9 % ( 95 % CI -2 to 20 ) in the placebo group , decreased by 12 % ( -28 to 4 % ; p = 0.0677 vs placebo ) in the 50 g eprotirome group , and decreased by 22 % ( -32 to -13 % ; p = 0.0045 vs placebo ) in the 100 g eprotirome group .