INF - , ICAM-1 , TGF - and IL-4 were significantly reduced in the LA group compared to the placebo group [ ( INF - : 0.82 0.2 vs. 0.2 0.2 pg/ml , p < 0.0001 ) , ( ICAM-1 : 20.2 9.4 vs. 8 10 ng/ml , p = 0.0001 ) , ( TGF - : 103.1 20.2 vs. 54.9 26 ng/ml , p < 0.0001 ) and ( IL-4 : 0.1 0.1 vs. 1.02 1.7 ng/ml , p = 0.0112 ) ] .