Fourteen healthy , male participants underwent a 10-day hypoxic confinement at 4000 m simulated altitude ( FIO2 = 0.139 0.003 % ) either combined with daily moderate intensity exercise ( Exercise group ; N = 8 , Age = 25.8 2.4 yrs , BMI = 22.9 1.2 kg m ( -2 ) ) or without any exercise ( Sedentary group ; N = 6 Age = 24.8 3.1 yrs , BMI = 22.3 2.5 kg m ( -2 ) ) .