In a multivariate model , haplogroup B was associated with increased ENFD ( = 3.5 , P = 0.009 ) at week 24 , whereas older age ( P = 0.02 ) , higher baseline CD4 cell count , ( P = 0.03 ) , higher complex I level ( P = 0.03 ) , and higher ENFD ( P < 0.001 ) at baseline were all associated with decreased ENFD .