Patients with any ciprofloxacin-containing antibiotic regimen the first 3 days in the trial had a higher risk of invasive Candida infection than did patients on any antibiotic regimen not containing ciprofloxacin ( unadjusted hazard ratio = 3.7 ; 95 % CI , 1.6-8 .7 ; p = 0.003 ; adjusted hazard ratio , 3.4 ; 95 % CI , 1.4-8 .0 ; p = 0.006 ) .