The significant statistical differences between the frequency of C and T allele for both SNPs ( C-511T and C +3953 T ) in the group studied and in the controls were found ( p = 0.0081 ; OR = 1.846 ; 95 % CI : 1.183-2 .878 and p = 0.0099 ; OR = 1.953 ; 95 % CI : 1.183-3 .224 ) .