Two treatment regimens were compared : No Titration dosing ( full 50mcg/m ( 2 ) subcutaneously [ s.c. ] three times weekly for 3 weeks ) and Titration ( 15mcg/m ( 2 ) s.c. three times weekly during week 1 , 30mcg/m ( 2 ) s.c. three times weekly during week 2 followed by the full dose of 50mcg/m ( 2 ) s.c. three times weekly during week 3 ) .