In Study 3 , beta cell glucose sensitivity was minimally affected , but the insulin secretion rate at 9 mmol/l glucose increased to similar degrees from baseline with canagliflozin and sitagliptin [ LSM ( SEM ) changes 38 ( 8 ) and 28 ( 9 ) pmol min ( -1 ) m ( -2 ) , respectively ; p < 0.05 for both ] .