LCIG-nave patients ( N = 29 ) showed a decrease in `` Off '' time and an increase in `` On '' time without troublesome dyskinesia ( change from baseline to final visit in mean [ SD ] hours = -2.34 [ 2.78 ] P < 0.001 and 2.19 [ 3.70 ] P = 0.005 , respectively ) , while continuing-LCIG patients ( N = 33 ) showed sustained `` Off '' time duration and further improvement in `` On '' time without troublesome dyskinesia ( -0.42 [ 2.67 ] P = 0.377 and 1.00 [ 2.58 ] P = 0.036 , respectively ) .