Current smokers ( n = 5,688 ) had an increased risk of ischemic events compared with never smokers ( n = 4,135 ; hazard ratio [ HR ] : 1.24 [ 95 % confidence interval ( CI ) : 1.08 to 1.42 ] ) and ex-smokers ( n = 9,381 ; HR : 1.32 [ 95 % CI : 1.18 to 1.47 ] ) ( p < 0.001 ) .