The least squares mean difference ( LSMD ) for change from baseline to week 3 in YMRS total score was statistically significant in favor of both cariprazine groups versus placebo ( LSMD [ 95 % CI ] : 3-6 mg/d , -6.1 [ -8.4 to -3.8 ] ; 6-12 mg/d , -5.9 [ -8.2 , -3.6 ] ; P < .001 [ both ] ) .