When initial procalcitonin was 0.25 g/L , procalcitonin-guided patients had significantly reduced antibiotic exposure due to early stop of therapy without any difference in adverse outcomes ( 25.8 % vs. 24.6 % , difference [ 95 % CI ] 1.2 % [ -14.5 % to 16.9 % , P = 0.88 ] ) .