Overall , 170 patients were randomly assigned to receive axitinib at a starting dose of 5-mg twice daily continuously plus pemetrexed 500 mg/m ( 2 ) and cisplatin 75 mg/m ( 2 ) on day 1 of up to six 21-day cycles ( arm I ) ; axitinib on days 2 through 19 of each cycle plus pemetrexed/cisplatin ( arm II ) ; or pemetrexed/cisplatin alone ( arm III ) .