In the whole cohort , aspartate aminotransferase ( AST ) serum levels were ( mean SD ) 35 3 at entry , 39 5 , 41 7 , and 38 4 at 14 , 30 , and 54 weeks , respectively ; alanine aminotransferase ( ALT ) serum levels were 43 5 at entry , 47 5 , 53 9 , and 50 6 at 14 , 30 , and 54 weeks , respectively .