After anakinra , there was a greater improvement of flow-mediated dilation ( 574 % versus 475 % ) , coronary flow reserve ( 374 % versus 292 % ) , arterial compliance ( 2018 % versus 217 % ) , resistance ( -1119 % versus 921 % ) , longitudinal strain ( 335 % versus 182 % ) , circumferential strain ( 225 % versus 135 % ) , peak twisting ( 305 % versus 125 % ) , untwisting velocity ( 235 % versus 135 % ) , ejection fraction ( 125 % versus 0.55 % ) , apoptotic and oxidative markers , and , in particular , of protein carbonyl ( 3520 % versus 149 % ) in CAD than in non-CAD patients ( P < 0.01 ) .