Rates of TIMI major bleeding were higher with ticagrelor ( 2.60 % with 90 mg and 2.30 % with 60 mg ) than with placebo ( 1.06 % ) ( P < 0.001 for each dose vs. placebo ) ; the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63 % , 0.71 % , and 0.60 % , respectively .