After 40 months , compared with baseline , mean ( SD ) creatinine-cystatin C-based GFR was -6.9 ( 12.6 ) , -4.8 ( 13.4 ) , -6.2 ( 12.8 ) , and -6.0 ( 13.0 ) ml/min per 1.73 m ( 2 ) in the placebo , eicosapentaenoic acid-docosahexaenoic acid , - linolenic acid , and eicosapentaenoic acid-docosahexaenoic acid plus - linolenic acid groups , respectively .