Multivariate analyses revealed NT-proCNP to be strongly predictive for the primary endpoint [ hazard ratio ( HR ) 1.78 , 95 % confidence interval ( CI ) 1.18-2 .67 , P = 0.006 ) in patients with HFpEF , but not in patients with a reduced ejection fraction ( HFrEF ) ( HR 1.07 , 95 % CI 0.81-1 .43 , P = 0.616 ) .