Data from an RCT ( Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes [ TEMPO ] ; n = 682 ) and an observational registry ( Rheumatoid Arthritis DMARD Intervention and Utilization Study [ RADIUS II ] ; n = 4341 ) were used to evaluate disease activity ( Clinical Disease Activity Index [ CDAI ] score ) over time in patients initiating etanercept ( monotherapy or with methotrexate ) .