The frequencies of the genotype C-511C compared to C-511T and T-511T as well as C +3953 C compared to C +3953 T and T +3953 T also differed significantly ( p = 0.0057 ; OR = 2.248 ; 95 % CI : 1.292-3 .912 and p = 0.0043 ; OR = 2.338 ; 95 % CI : 1.305-4 .191 ) between patients and controls .