Relative reduction of body weight was significantly greater in the verum group ( -3.73 % ; CI = -4.70 to -2.76 ) than in the placebo group ( -0.70 % ; CI = -1.57 to +0.16 ; p < 0.001 ) In addition we also observed a significant reduction of BMI ( p < 0.001 ) in the verum group ( -3.62 % ; CI = -4.39 to -2.84 ) compared to placebo ( -0.82 % ; CI = -1.55 to -0.10 ; p < 0.001 ) .