The insulin sensitivity allele score ( GS-InSens ) was positively associated with spontaneous postnatal weight gain ( regression coefficient [ B ] : 0.12 SD scores per allele ; 95 % confidence interval [ CI ] , 0.01-0 .23 ; P = .03 ) and also in response to GH therapy with first-year height velocity ( B : 0.18 cm/y per allele ; 95 % CI , 0.02-0 .35 ; P = .03 ) and change in IGF-1 ( B : 0.17 SD scores per allele ; 95 % CI , 0.00-0 .32 ; P = .03 ) .