There was a significant decrease of 4.9 % ( 3.25 DRD ) in the IG ( 95 % CI : 1.0 % -8.6 % ) ( P = 0.02 ) compared with a significant increase of 5.1 % ( 2.24 DRD ) in the CG ( 95 % CI : 0.2 % -10.2 % ) ( P = 0.04 ) .