Clopidogrel was associated with a reduction in ischemic events among current smokers ( 8.3 % vs. 10.8 % ; HR : 0.76 [ 95 % CI : 0.64 to 0.90 ] ) , whereas no benefit over aspirin was seen in the combined group of ex-smokers/never-smoked patients ( 10.4 % vs. 10.6 % ; HR : 0.99 [ 95 % CI : 0.89 to 1.10 ] ; p = 0.01 for interaction ) .