Decreased LV compliance , measured as reduced LV end-diastolic volume at an idealized LV end-diastolic pressure of 20 mm Hg ( EDV20 ) , and RV remodeling , as indicated by increased RV wall thickness , were the 2 pathophysiologic markers most predictive of worse outcomes : adjusted hazard ratio per 1 SD decrease in EDV20 = 1.39 ( 95 % confidence interval [ CI ] , 1.10-1 .75 ; P = 0.006 ) , and hazard ratio per 1 SD increase in RV wall thickness = 1.37 ( 95 % CI , 1.16-1 .61 ; P < 0.001 ) .