At 20 weeks , the alanine aminotransferase level was normal in 11 of 36 patients ( 31 % ) in the sebelipase alfa group and in 2 of 30 ( 7 % ) in the placebo group ( P = 0.03 ) , with mean changes from baseline of -58 U per liter versus -7 U per liter ( P < 0.001 ) .