PAR was lower after treatment with valsartan ( 11.49 0.69 % vs. 18.71 2.47 % , P < 0.001 ) , associated with more reduced plasma levels of COX-2 ( 76.94 7.07 U/L vs. 116.4 15.89 U/L , P < 0.001 ) and TXB 2 ( 1667 56.50 pg/ml vs. 2207 180.20 pg/ml ) ( all P < 0.001 ) .