Placebo-subtracted least squares mean ( LSM ) ( SEM ) changes were 23 ( 9 ) and 18 ( 9 ) pmol min ( -1 ) m ( -2 ) ( mmol/l ) ( -1 ) with canagliflozin 100 and 300 mg , respectively ( p < 0.002 , Study 1 ) , and 16 ( 8 ) and 10 ( 9 ) pmol min ( -1 ) m ( -2 ) ( mmol/l ) ( -1 ) ( p < 0.02 , Study 2 ) .