In multivariable analyses , adjusting for left ventricular ejection fraction , NYHA class , age , body mass index , diabetes mellitus , sex , intermittent claudication , heart rate , estimated glomerular filtration rate , apolipoprotein B/apolipoprotein A-1 ratio , amino-terminal probrain natriuretic peptide , high-sensitivity C-reactive protein , and hs-cTnT ( both dichotomized according to the 99th percentile and as a continuous variable ) was associated with all end points ( primary end point : hazard ratio , 1.87 and 1.51 , respectively , per SD change ; P < 0.001 ; all other end points : hazard ratio , 1.39-1 .70 ) .