Resveratrol supplementation led to a significant reduction in plasma levels of TNF - ( 19.70 12.80 to 17.20 10.09 pg/mL ) and hs-CRP ( 4764.25 2260.48 to 2584.50 1792.80 ng/mL ) and activity of NF-B in PBMCs ( 0.19 0.05 to 0.10 0.04 OD ) ( p < 0.001 ) , whereas there were no significant changes of these factors in placebo group .