Explorative outcomes will be : all cause mortality at 28 days after randomisation ; days until discharge from the intensive care unit ; days until the participant is without mechanical ventilation ; days until discharge from the hospital ; organ failure.Trial size : we will include 700 participants ( 2350 ) in order to detect or reject 25 % relative risk reduction in mortality with a type I error risk of 5 % and a type II error risk of 20 % ( power at 80 % ) .