Improvements for UMEC/VI 125/25 mcg vs placebo were observed for the transition dyspnea index ( 1.0 unit ; p < 0.001 ) , rescue albuterol use at Weeks 1-24 ( -1.5 puffs/day ) and St. George 's Respiratory Questionnaire ( -3.60 units , p < 0.001 ) .