Noninferiority ( ie , meeting the prespecified 90 % CI lower limit of 0.8 ) was then confirmed in stage 2 , with geometric mean Ctrough SC : Ctrough IV ratios for the 2 - and 3-month regimens of 1.24 ( 90 % CI , 1.02 to 1.51 ) and 1.12 ( 90 % CI , 0.86 to 1.45 ) , respectively .