The insulin secretion allele score ( GS-InSec ) was positively associated with spontaneous postnatal height gain ( B : 0.15 ; 95 % CI , 0.01-0 .30 ; P = .03 ) and disposition index both before ( B : 0.02 ; 95 % CI , 0.00-0 .04 ; P = .04 ) and after 1 year of GH therapy ( B : 0.03 ; 95 % CI , 0.01-0 .05 ; P = .002 ) , but not with growth and IGF-1 responses to GH therapy .