Week 26 mean HbA1c reductions from baseline ( 8.45 % ) were -1.22 and -1.55 % with A+M 12.5 / 500 and 12.5 / 1000 versus -0.56 , -0.65 , and -1.11 % with A12 .5 , M500 and M1000 ( p < 0.001 , A+M vs. component monotherapies ) .