After a 1-month run-in period using twice-daily insulin glargine ( or usual basal insulin therapy for pump users ) with prandial lispro , 46 subjects with T1D ( 42 13 years ; body mass index : 26 4 kg/m ( 2 ) ; A1c : 6.8 0.5 % ) were assigned to INSULIN-PH20 or lispro in a random sequence for two consecutive , 12-week periods as the prandial insulin in an intensive treatment regimen .