With the linagliptin 2.5 mg/metformin 500 mg dose , the ratio with linagliptin for AUC0-72 and Cmax was 100.81 % ( 90 % CI : 95.14-106 .82 ) and 111.37 % ( 90 % CI : 100.40-123 .54 ) , respectively ; the same statistical parameters with metformin for AUC0-tz and Cmax were 102.95 % ( 90 % CI : 96.24-110 .12 ) and 102.46 % ( 90 % CI : 92.20-113 .87 ) , respectively .