At week 12 , adjusted mean difference versus placebo in change from baseline in mean 24-h SBP ( ambulatory blood pressure monitoring [ ABPM ] ) was -3.44 mmHg ( 95 % CI -4.78 , -2.09 ) with 10 mg empagliflozin and -4.16 mmHg ( -5.50 , -2.83 ) with 25 mg empagliflozin ( both P < 0.001 ) .