Fluralaner was administered on three occasions at 8-week intervals at doses of up to 56 , 168 , and 280 mg fluralaner/kg body weight , equivalent to 1 , 3 , and 5 times the highest recommended treatment dose of fluralaner ; sham dosed dogs served as controls.During the study , all dogs were clinically observed , and their health was carefully monitored including body weight development , food consumption and measurement of hematology , coagulation , clinical chemistry ( including measurement of levels of ACTH and C-reactive protein ) and urinalysis .