Fewer patients assigned to the weekly group than those allocated treatment every 3 weeks had grade 3-4 neutropenia ( 167 [ 42 % ] of 399 patients vs 200 [ 50 % ] of 400 patients ) , febrile neutropenia ( two [ 05 % ] vs 11 [ 3 % ] ) , grade 3-4 thrombocytopenia ( four [ 1 % ] vs 27 [ 7 % ] ) , and grade 2 or worse neuropathy ( 24 [ 6 % ] vs 68 [ 17 % ] ) .