The serum creatinine level was lower in the RIC group compared with that of the control group ( 12h , days 1-14 , P < 0.05 ; other P > 0.05 ) ; the estimated glomerular filtration rate was higher in the RIC group compared with that of the control group ( 12h , days 1-14 , P < 0.05 ; other P > 0.05 ) ; urine neutrophil gelatinase-associated lipocalin , an early marker of IRI , was lower in the RIC group at hours 2 , 12 , 24 , and 48 ( 2 h , 48h , P > 0.05 ; 12h , 24h , P < 0.05 ) compared with that of the control group .