Healthy volunteers were randomized to receive 4 consecutive inhalations ( each administered as a single dose ) via a single ELLIPT dry powder inhaler : in study 1 ( CTT116415/NCT01691547 ) , FF/UMEC/VI at total doses of 400/500/100 g , FF/UMEC 400/500 g , UMEC/VI 500/100 g , or FF/VI 400/100 g ; in study 2 ( 200587/NCT01894386 ) , FF/UMEC/VI at total doses of 400/500/100 g or 400/250/100 g , FF/VI 400/100 g , or UMEC/VI 250/100 g. PK and PD parameters and safety were assessed .