With a median follow-up of 5.9 years , the 3-year EFSs were 75.4 % and 78.2 % , respectively , the 3-year EFS difference was -2.8 % ( 91.4 % CI , -7.8 to 2.2 % ) , the HR ( event ) was 1.12 ( 91.4 % CI , 0.89 to 1.41 ) , and the HR ( death ) was 1.09 ( 91.4 % CI , 0.84 to 1.42 ; intention-to-treat ) .