With the linagliptin 2.5 mg/metformin 850 mg dose , the adjusted geometric mean ratio of the SPC to the separate tablets for linagliptin was 99.53 % ( 90 % confidence interval ( CI ) : 94.75-104 .55 ) for AUC0-72 and 101.93 % ( 90 % CI : 95.36-108 .95 ) for Cmax ; for metformin the ratio was 96.99 % ( 90 % CI : 90.62-103 .81 ) for AUC0-tz and 94.64 % ( 90 % CI : 85.43-104 .84 ) for Cmax .