The least squares mean WAI ( uNTx/Cr ) at week 4 was 42.8 % ( 90 % CI , 35.5 % -49.3 % ) for men and 42.7 % ( 90 % CI , 30.3 % -52.9 % ) for women ; mean values were > 40 % , but lower bounds were < 40 % as prespecified in the primary hypothesis .