The Rome III score improved significantly in patients receiving mineral oil ( 10.55.0 to 4.14.0 ; P < .01 ) , olive oil ( 10.34.2 to 3.23.8 ; P = .01 ) , and flaxseed oil ( 9.64.2 to 6.05.1 ; P < .01 ) , with no significant group-by-time interaction ( P = .15 ) .