According to "Baishoron," Takauji regretted having turned against Emperor Go-Daigo, and he for a while he was talking about becoming a priest. In the heat of battle he also talked about killing himself, so Shin'ichi SATO took these descriptions into consideration, and presumed that Takauji might have been a manic depressive.
『梅松論』などによると、尊氏は後醍醐に背いて朝敵となったことを悔やんで一時は出家を宣言したり、合戦で苦戦した際には切腹すると言い出すなどの記述があり、佐藤進一は尊氏を躁鬱病ではないかと推測している。