During the Kyotoku Incident, the Ogigayatsu- and Yamanouchi-Uesugi families formed an alliance and fought against the Koga Kubo (the later form of the Kamakura Kubo) but after making peace, they began to fight among themselves, leading to a decline in their power, and they came under pressure from the emerging Gohojo clan.
享徳の乱の際、扇谷・山内両上杉家は連合して古河公方（鎌倉公方の後身）と敵対していたが、古河公方との和睦後は両家で争うようになり、内紛の末に衰退し、新興の後北条氏に圧迫されるようになる。