Before long, due to the death of Nagayoshi, the Miyoshi clan shifted their system to the leaderships by Miyoshi Sanninshu (Miyoshi Triumvirate), but they started to suffer through the correspondence to the 13th Shogun Yoshiteru ASHIKAGA who proposed exclusion of the Miyoshi clan from bakufu.
やがて、長慶の死去に伴い、三好氏では三好三人衆による指導体制に移行されたが、幕政からの三好氏排除を目論む13代将軍・足利義輝への対応に苦慮するようになる。