With the translation of "Kaitai Shinsho" (New Book of Anatomy), followed by the apprentice's education in Genpaku SUGITA's Tenshinro Building, and in addition, Gentaku OTSUKI's publication of "Rangaku Kaitei" (an introductory book of the Western science study by Masatsuna KUTSUKI), the apprentice's education in Shiran-do, the western sciences came to have a general popularity.
『解体新書』の翻訳、それに続く杉田玄白の天真楼での弟子の育成、さらに大槻玄沢の『蘭学階梯』の出版と芝蘭堂での弟子の育成によって、蘭学は一般的な広がりを持つようになった。