After the Eiroku no hen (the Eiroku Incident), Fujitaka and Mitsuhide AKECHI came to rely upon daimyo Nobunaga ODA of Owari Province/Mino Province and backed Yoshiteru's younger brother Yoshiaki as shogun, however, Tadaoki became a vassal of Nobunaga when Nobunaga and Yoshiaki had a confrontation.
永禄の変の後、藤孝や明智光秀らは尾張国・美濃国の大名織田信長を頼って義輝の弟・義昭を将軍に擁立したが、やがて信長と義昭が対立すると信長に臣従した。