For a period of time after that, he fought against the anti-Nobunaga forces such as Miyoshi Triumvirate in and around Kyoto as a Nobunaga's vassal (the Battle of Noda-jo Castle and Fukushima-jo Castle), but around 1571 he allied himself with Hisahide to rebel against Nobunaga, and took part in the siege around Nobunaga.
その後しばらくは織田氏の家臣として三好三人衆などの畿内の反信長勢力と戦っていたが（野田城・福島城の戦い）、元亀2年（1571年）頃から久秀と手を結んで信長に反逆し、信長包囲網の一角に加わった。