The Ogigayatsu-Uesugi family, which held power in Musashi Province, was defeated and destroyed by the Gohojo clan at the Kawagoe Night Battle in 1545, and Norimasa UESUGI of the Yamanouchi-Uesugi family, who was based in Kozuke Province, began to receive direct attacks from the Gohojo Clan, causing their power to also deteriorate.
武蔵国に勢力をもっていた扇谷上杉家は、1545年の河越夜戦で後北条氏に敗れて滅亡し、上野国を本拠としていた山内上杉家の上杉憲政も、河越夜戦以降は後北条氏の攻撃を直に受けるようになって勢力を衰退させていった。