Ansei no Taigoku lead to a decrease in general awareness and a shortfall in human resources in the shogunate, plus intensified Sonno activities by the anti-shogunate group, and it is said these were underlying causes in the fall of the government.
安政の大獄は幕府の規範意識の低下や人材の欠如を招き、反幕派による尊攘活動を激化させ、幕府滅亡の遠因ともなったとも言われる。