Just before Iesada's death, Tairo (chief minister), Naosuke II, and Iesada's biological mother, Honjuin, decided to give his doctors permission to come to Edo-jo castle; and those doctors were Chinese medicine doctors, Choan TODA, and Ranpoi (a person who studied Western medicine by means of the Dutch language), Genboku ITO and Seikai TOTSUKA.
家定の死の直前、大老井伊直弼と実母の本寿院との判断で、漢方医青木春岱・遠田澄庵、蘭方医伊東玄朴・戸塚静海が江戸城登城を許される。