Sadamune ISE, a child of Sadachika, and Sadamichi ISE, a grandson of Sadachika, cooperated with Masamoto HOSOKAWA who was from the rising Hosokawa clan and continued to have the influential position in the bakufu..
貞親の子の伊勢貞宗、孫の伊勢貞陸は台頭する細川氏の細川政元と協調し引き続き幕政に重きをなした。