Reponding to the request for the military power by Takauji ASHIKAGA who had defected from Emperor Godaigo's Kenmu government established after the fall of the Kamakura bakufu, Nobutake raised an army in 1335 and offended Yano-jo Castle (Hiroshima City) which was the headquarters of Rengaku KUMAGAI who hoisted the opposition banner.
鎌倉幕府滅亡後のに発足した後醍醐天皇の建武政権から離反した足利尊氏の軍勢催促に応じ、建武2年に挙兵し、叛旗を翻した熊谷蓮覚の本拠矢野城（広島市）を攻略している。