At the age of 22, he went to Edo to enter Gentaku OTSUKI's private school called Shiran-do, and after that, he followed one of the best four of Shiran-do, Sanpaku INAMURA who moved to Kyoto, and studied Western learning and Western medical science under him.
22歳の時に江戸に出て大槻玄沢の私塾・芝蘭堂に入門、のちに京都府に移り住んだ芝蘭堂四天王の一人、稲村三伯を追って師事し蘭学や蘭方医学を学んだ。