The Echigo-Uesugi family, who were hereditary Shugo of Echigo Province, split into the Inukake-Uesugi family (through adoption, it is the Yamanouchi Uesugi family by bloodline), and within Echigo Province, the Sanbonji-Uesugi family, the Yamaura-Uesugi family and the Jojo-Uesugi family.
また、犬懸上杉家から越後守護を世襲する越後上杉家が分かれ（養子により血統的には山内上杉家）、越後国内に山本寺上杉家、山浦氏、上条上杉家を分家した。