The first reference to Kannoosan-jo Castle in historical sources can be found in the descriptions of the Battle of Katsuragawa River, and the Battles of Yagami-jo Castle and Kannoosan-jo Castle, which state that a castle called Kannoosan-jo Castle was built in Settsu Province by Tadakata HOSOKAWA in early 1526.
神尾山城が史上に現れるのが桂川原の戦い八上・神尾山両城の戦いの時で、大永6年（1526年）の初旬、細川尹賢が摂津国で築城していた。