One was that Kenshin still in his twenties fell in love with Isehime, a daughter of Uneme CHIBA an enemy commander and lord of Hirai-jo Castle in Kozuke Province, they were torn apart by strong opposition from a senior vassal (Kageie KAKIZAKI and others), after taking tonsure and becoming a priest, the daughter killed herself, Kenshin was distressed to the extent of not eating and finally becoming bedridden ('Shorin Yawa').
ひとつは、彼がまだ二十代の折、敵将の上野・平井城主千葉采女の娘である伊勢姫と恋に落ちたが、重臣（柿崎景家ら）の猛烈な反対によって引き裂かれ、娘が剃髪出家した後、ほどなくして自害してしまい、食事ものどを通らず病床に伏せてしまうほどに心を痛めたというもの（「松隣夜話」）。