The Kira clan was related to the Ogigayatsu-Uesugi clan by old marriage connections, and he had two sons and four daughters (the eldest son Tsunanori UESUGI, the second son Saburo KIRA, the eldest daughter Tsuruhime, the second daughter Furihime, the third daughter Akurihime, and the fourth daughter Kikuhime) (however, the second son Saburo and the second daughter Furihime died young).
また、吉良氏が古くからの婚姻関係によって扇谷上杉氏の血を引いており、二男四女（長男上杉綱憲、次男吉良三郎、長女鶴姫、次女振姫、三女阿久利姫、四女菊姫）に恵まれた（ただし次男・三郎と次女・振姫は夭折）。