It was the residence of Sekkan-ke (the family lines which produced regents) of the Nijo family before becoming 'Nijo New Imperial Palace' of Imperial Prince Sanehito, which was where Nobutada ODA died in battle during the Honnoji Incident.
後に二条家摂関家の邸宅を経て、本能寺の変の際に織田信忠が戦死した二条城織田信長・誠仁親王の「二条新御所」となる。