He deployed the following busho: Katsuie SHIBATA, Toshiie MAEDA, Narimasa SASA, and others against Kagekatsu UESUGI who succeeded the head of the Uesugi family through a family feud after the death of Kenshin UESUGI; his legitimate son Nobutada, Kazumasu TAKIGAWA, Nagayoshi MORI and others against Katsuyori TAKEDA; Mitsuhide AKECHI, Yusai HOSOKAWA and others against Hideharu HATANO (the battle of Kuroi-jo Castle); Hideyoshi HASHIBA against Terumoto MORI and Nobumori SAKUMA against the Ishiyama Hongan-ji Temple.
上杉謙信の死後、お家騒動を経て上杉氏の家督を継いだ上杉景勝に対しては柴田勝家、前田利家、佐々成政らを、武田勝頼に対しては嫡男・信忠、滝川一益、森長可らを、波多野秀治に対しては明智光秀、細川幽斎らを（黒井城の戦い）、毛利輝元に対しては羽柴秀吉を、石山本願寺に対しては佐久間信盛を配備した。