But in 1506, when Jitsunyo agreed to Masamoto HOSOKAWA's request to cooperate in the subjugation of Yoshihide HATAKEYAMA, Jodo Shinshu followers from Settsu and Kawachi Provinces, who had strong ties to the Hatakeyama clan, furiously opposed him, and consequently Jitsunyo's younger brother by a different mother, Jitsugen, himself descended from the Hatakeyama clan, demanded, with the backing of Ishiyama Gobo (later became Omi Province's Shotoku-ji Temple), that he replaced Jitsunyo as Hoshu (high priest) of the Jodo Shinshu Sect.
だが、1506年（永正3年）、細川政元の要請を受けて畠山義英討伐への協力に応じると、畠山氏との関係が深かった摂津国・河内国の門徒が猛反発し、実如の異母弟で畠山氏の血を引く実賢（後に近江国称徳寺）を石山御坊にて擁立して法主交替を求める。