With the collapse of the Kamakura bakufu and the ensuing turmoil of the Northern and Southern Court Period, the Edo clan initially allied itself to the Southern Court serving Yoshisada NITTA, but later changed allegiances to the Northern Court and served as the Kamakura Kubo (Governor-general of the Kanto region).
鎌倉幕府が滅びると、江戸氏は南北朝時代(日本)の騒乱において初め新田義貞に従って南朝(日本)方につき、後に北朝(日本)に帰順して鎌倉公方に仕えた。