In the Kaei era (1848-1854), a young general practitioner, Yukiyasu SHIMADA had been treating people in his 'Jinriki Toyaku-chogojo' (gods' power pharmacy) in Wakayama City (Kii Province), and his treatment and prescription by gods' power was very popular among the city as the demonstration of gods' power had great effects.
嘉永の時代に、紀州若山在住の若い町医者島田幸安は、その城下町で「神力睹薬調合所」を開き、彼の神通力と神の導きによる薬の調合は実に霊験あらたかで、和歌山市中ではかなりの評判を呼んでいた。