After the death of Prince Shotoku, his prince, Prince Yamashiro no oe lived in the palace, however, the palace was burnt away by SOGA no Iruka's soldiers in 643, and Prince Yamashiro no oe and other people in Jogu Oke (Prince Shotoku's family) were forced to kill themselves in Horyu-ji Temple.
太子の薨去後、太子の王子山背大兄王が住んだが、皇極天皇2年（643年）に蘇我入鹿の兵によって宮は焼き払われ、山背大兄王以下、上宮王家の人々は法隆寺で自殺に追い込まれた。