In 1551, however, the Omiya family was attacked and destroyed by Takafusa SUE, who raised an army in rebellion against Yoshitaka OUCHI (an event known as the Taineiji Incident).
しかし、天文(元号)20年（1551年）に大宮家は大内義隆に対する謀反の兵を挙げた陶隆房によって攻められて滅亡した（大寧寺の変）。