During the Muromachi period being enrolled on the hokoshu (or banshu; the shogunal military guard), the Nose clan became gokenin (immediate vassal of the shogunate) and grew into a powerful local lord in Settsu Province.
室町時代には幕府の奉公衆（番衆）に加えられ直参の御家人となり、摂津の有力国人へと成長する。