The clan declined in one stroke when it was defeated in the Battle of Nagashino and lost senior vassals who had served from the era of Shingen, and it was eventually ruined in 1575 by the attack of Nobunaga ODA (the Battle of Tenmokuzan).
1575年長篠の戦いに敗北、信玄時代からの重臣を失うと一挙に衰退し、1582年織田信長に攻め込まれて滅亡した（天目山の戦い）。