In 1846, he entered Genkyo HIROSE's Jishudo school in Kyoto, and then in 1848, he studied in the Tekijuku (the school of the Western studies) opened by Koan OGATA in Osaka and also entered Shunrinken (Medical school, hospital and accommodation in Edo period) founded by Seishu HANAOKA in Kii.
1846年（弘化3年）、京都で広瀬元恭の時習堂に入門し、1848年（嘉永元年）には大坂の緒方洪庵の適塾で学び、さらに紀伊で華岡青洲が開いた春林軒塾に入門する。