The production of Hinowan gradually declined partly because the merchants replaced their major merchandise with medicine, and partly because Hino was devastated in 1756 by a great fire (that reduced about 80% of the downtown to ruins).
その後、日野商人の主力商品が薬に代わったことや、宝暦6年1756年の日野大火（市街地の約８割を焼失）で打撃を受け徐々に衰微。