In June 1507, Masamoto's hikan (low-level bureaucrat) Motonaga KOZAI and Nagatada YAKUSHIJI brought Eisho Disturbance, which was assassination of Masamoto HOSOKAWA.
永正4年（1507年）6月、政元の被官・香西元長・薬師寺長忠らが政元を暗殺する永正の錯乱が起こる。