And then on May 19th, 1565, Hisahide and the Miyoshi Triumvirate revolted against Yoshiteru with their lord Yoshitsugu MIYOSHI (Nagayoshi's (Chokei's) adopted heir), setting up Yoshihide ASHIKAGA as their puppet leader (Eiroku no Hen).
そして、永禄8年（1565年）5月19日、久秀と三好三人衆は主君・三好義継（長慶の養嗣子）とともに足利義栄を奉じて謀叛を起こした（永禄の変）。