In response, Mototsune sided with Harumoto and fought Ujitsuna, but since one of close retainers of Harumoto, Nagayoshi MIYOSHI, betrayed his master and sided with the Hosokawa clan, Mototsune's army was defeated (in the Battle of Eguchi), and his territory was eventually bereaved by Nagayoshi.
これに対して元常は晴元と共に氏綱と戦ったが、天文18年（1549年）に晴元の重臣・三好長慶が裏切って氏綱に味方したために敗れ（江口の戦い）、結果的には細川氏の所領は長慶によって奪われる形となった。