In Masamori TAKANASHI's time, to strengthen the connection between the Takanashi and Nagao clans, the deputy governor of Echigo, Masamori, had his daughter marry Yoshikage NAGAO (since Masamori and Yoshikage were at the same age, she was probably a daughter of Masataka) and the daughter bore Tamekage NAGAO (the father of Kenshin UESUGI), who ultimately became a deputy governor of Echigo, so that the Takanashi clan was involved in the conflict between the Uesugi clan, the governor of Echigo, and the Nagao clan in Echigo during the late Muromachi period.
高梨政盛の代に、越後守護代の長尾氏と関係を強めるため、長尾能景に娘（政盛と能景は同年代であるため、政高の娘である可能性が高い）を嫁がせるが、その娘が産んだ長尾為景（上杉謙信の父）が越後守護代となり、室町末期には越後で守護上杉氏と長尾家の争いが起きると、高梨氏もそれに巻き込まれることになった。