At first, he was in a cooperative relationship with Nobunaga, but gradually came into conflict with him because of Nabunaga's attempts to control the Shogun's power, such as Denchu on okite (regulations for the shogunal residence) issued by Nobunaga in 1569.
当初は信長と協調関係にあったが、将軍権力の抑制を図る信長の一連の動き（永禄12年（1569年）1月に信長が出した殿中御掟等）により次第に信長と対立するようになった。