His children areYoshinori UESUGI, Norimasa UESUGI, Norikata UESUGI, Noriharu UESUGI, Norikata UESUGI, Noriyoshi UESUGI (Echigo Uesugi Family), Norifusa UESUGI (Kobanawa Uesugi Family), Naokuni IWAMATSU's lawful wife, and Tomofusa UESUGI's lawful wife.
子に上杉能憲、上杉憲将、上杉憲賢、上杉憲春、上杉憲方、上杉憲栄（越後上杉家）、上杉憲英（庁鼻和上杉家）、岩松直国室、上杉朝房室がいる。