In 645, the first year of the era of Taika, SOGA no Iruka was assassinated by Emperor Tenchi and FUJIWARA no Kamatari; Iruka's father, Emishi, committed suicide and the Soga clan was destroyed (this incident is known as 'Isshi no hen' or otherwise known as 'The Murder in the Year of Isshi').
皇極天皇4年・大化元年（645年）天智天皇と藤原鎌足により蘇我入鹿が暗殺され、父の蝦夷は自殺して蘇我氏は滅亡した（乙巳の変）。