However, in the time of Masamoto after Katsumoto HOSOKAWA died, the family often opposed to the Keicho family, which was seeking the concentration of its power, and the family was involved in the rebellion of Motokazu YAKUSHIJI, who was a deputy Shugo of the Settsu Province.
しかし、細川勝元の没後、政元の時代においては、権力集中を図る京兆家としばしば対立し、摂津守護代の薬師寺元一の反乱に関与するなどした。