In the later Kamakura period, a branch family of the Isawa-lineage Takeda clan, having a connection with the Tokuso Family of Hojo clan, inherited Kai no Shugo (the provincial constable of Kai Province) instead of the Nobutoki-lineage Takeda clan who had transferred the headquarters as Aki no Shugo.
鎌倉時代後期には、安芸守護として本拠を移した信時流武田氏に代わって甲斐守護は北条得宗家と結びついた庶流石和流武田氏が継承した。