Since then, Takakage actively cooperated with Hideyoshi, defeated Michinao KONO of the Iyo Province and rendered other great services in the Conquest of Shikoku in 1585, and was granted the Iyo Province by Hideyoshi after the conquest.
その後は秀吉に積極的に協力し、天正13年（1585年）の四国征伐では伊予国の河野通直を破るなどの功績を挙げ、戦後に秀吉から伊予一国を与えられた。