Despite the fact that both the imperial court and the Toyotomi regime were strongly opposed to this, Ieyasu TOKUGAWA who seized political power after winning the Battle of Sekigahara in 1600 accepted the intension of Emperor Go-Yozei on the condition to disinherit Imperial Prince Ryonin, who was strongly in favor of the Toyotomi regime, and Imperial Prince Kotohito (who later became Emperor Go-Mizuno), the third son of Sakiko KONOE who was a court lady and the emperor's lawful wife, to be the next in line for the throne instead.
この時は朝廷・豊臣政権ともに強く反対して中止されるものの、慶長5年（1600年）関ヶ原の戦いに勝利して政治の実権を握った徳川家康は豊臣政権色の強い良仁親王を廃して、天皇の正室である女御近衛前子が生んだ第三皇子の政仁親王（後の後水尾天皇）を代わりに立てることを条件に天皇の意向を受け入れた。