Although he fought against Takakuni and Yoshioki from 1509 to recover Kyoto, he was defeated (Battle of Nyoigatake) and lost his son, Nagahide MIYOSHI.
永正6年（1509年）から高国・義興と戦って京都奪還を目指したが敗れ（如意ケ嶽の戦い）、子の三好長秀を失った。