Doyo SASAKI (Takauji) who became the family head, at the end of the Kamakura period, worked as Kebiishi, officers having function of police and judge, in the Imperial court and as gosobanshu, an advisor in the Kamakura bakufu, but in 1333 when Takauji ASHIKAGA received the order from the Emperor Godaigo to topple the bakufu, Doyo contributed to it and was involved in the new administration.
鎌倉時代末期に当主となった佐々木道誉（高氏）は、朝廷で検非違使、鎌倉幕府で御相伴衆を務めていたが、元弘3年（1333年）に後醍醐天皇の綸旨を受けた足利尊氏が倒幕の兵を挙げると、それに寄与し建武の新政に加わる。