However, he could not achieve any results in the siege of the Ishiyama, which irritated Nobunaga; when Nobunaga made peace with the Hongan-ji Temple by pressuring the Imperial Court in 1580, Nobuhide and his father were expelled to Koyasan with a letter of reprimand which consisted of 19 articles.
しかし、石山攻めでは一向に結果が出せず、業を煮やした信長が天正8年（1580年）朝廷を動かして本願寺と和睦すると、19ヶ条に渉る譴責状を突きつけられて父共々高野山に追放された。