Tadashige was killed by Mitsunari ISHIDA's side just before the Battle of Sekigahara in 1600; yet his sons, Katsunari MIZUNO and Tadakiyo MIZUNO served Ieyasu as great vassals; Katsunari became the originator of the Mizuno family of the Bingo-Fukuyama Domain in Bingo Province and the Yuki Domain in Shimosa Province and while Tadakiyo became the originator of the Mizuno family of the Numazu Domain in Suruga Province and the Tsurumaki Domain in Kazusa Province.
1600年、関ヶ原の合戦の直前に石田三成方に殺害されるが、その子水野勝成と水野忠清は直臣として家康に仕え、勝成が備後国備後福山藩・下総国結城藩水野家の祖、忠清は駿河国沼津藩水野家および上総国鶴牧藩水野家の祖となる。