From psychological viewpoints, one assumes that Kenshin was influenced by his mother, Seiganin, and his older sister, Sentoin (Kagekatsu's mother), who were religious and splendid women (a theory that men who are deeply loved by noble women in childhood, unconsciously seek the same nobleness from other women when growing up, and they are gradually disillusioned with and show less interest in surrounding women), Kenshin may have been one such person, there are other theories including a kind of vulgar belief that Kenshin UESUGI was intersexual or female, also that he strictly observed a ban of marriage based on the belief of Bishamonten or Izuna-gongen.
心理学的な観点から、信心深く立派な女性であった母青岩院と姉仙桃院（景勝の母）の影響があったと推測する見方（幼少期に高潔な人格の女性から深い愛情を注がれた男性は、成長すると他の女性にも同じ高潔さを無意識に求めるため、次第に周囲の女性に幻滅して興味を示さなくなる傾向にあり、謙信もその一人だったのではないかというもの）や、半陰陽説や上杉謙信女性説といった俗談の類から、毘沙門天あるいは飯縄権現信仰の妻帯禁制を堅く守っていたとする説などが存在する。