However, his relations with Yoshitsugu MIYOSHI and Hisahide MATSUNAGA gradually worsened as a result of the leadership struggles in the Miyoshi family, and they went to war in 1566.
しかし、三好家中における主導権争いから三好義継や松永久秀とは次第に対立を深め、永禄9年（1566年）に入ると両者は交戦状態に突入した。