Meanwhile, Motonaga's progeny Nagayoshi MIYOSHI, who was taking over the family estate as the head of the Miyoshi family, requested Harumoto to kill his kin Masanaga MIYOSHI in 1548, however, this request was rejected by Harumoto and Nagayoshi switched to the Ujitsuna side in 1549.
しかし天文17年（1548年）、元長の嫡男で三好宗家の家督を相続していた三好長慶が、晴元に一族の三好政長の討伐を要請し、これを拒否されたため、天文18年（1549年）に氏綱側に寝返った。