At the end of the Edo period, the Mizuno clan members lorded over the Yuki Domain in Shimosa Province, Numazu Domain in Suruga Province, Tsurumaki Domain in Kazusa Province, and Yamagata Domain in Dewa Province.
幕末期において、下総国結城藩、駿河国沼津藩、上総国鶴牧藩、出羽国山形藩の各藩の藩主が水野氏であった。