Initially they aligned with the Ogasawara clan of Shinano Province in battles against the Takeda clan however, in 1561 on behalf of Morimasa NISHINA they fell to the Takeda Clan whereby Morinobu NISHINA (the 5th son of Shingen TAKEDA) was adopted into the family and became successor of the Nishina clan.
初め信濃小笠原氏に属して武田氏と戦っていたが、1561年（永禄4年）の仁科盛政の代に武田氏に降り武田信玄の五男、仁科盛信が養子となり仁科氏を継いだ