However, the resistance from the old power did not stop, and Takamasa HATAKEYAMA, one of sankanrei (three families in the post of kanrei, or shogunal deputy) and Yoshikata ROKKAKU, the hankoku shugo (military governor in charge of the half area of the province) and male cousin of Harumoto HOSOKAWA raised rebellion against Miyoshi.
しかし、旧勢力の抵抗は止むことなく、河内・紀伊の守護で三管領のひとつ畠山氏の畠山高政、南近江の半国守護で細川晴元の従兄弟の六角義賢らは反三好の兵を起こすなどした。