In the late Kamakura period, the eighth family head, Yoshisada NITTA, following the movement to overthrow the bakufu by the Emperor Godaigo, raised an army and attacked Kamakura, while adding Senjuo (later Yoshiakira ASHIKAGA), the legitimate son of Takauji ASHIKAGA who was the most dominant gokenin coming from the same family descended from Yoshikuni with a matrimonial relation with the Hojo clan for generations, and overthrew the bakufu.
鎌倉時代後期には、8代新田義貞が後醍醐天皇の倒幕運動に従い挙兵、源義国流の同族にして北条氏と重代の姻戚の最有力御家人足利尊氏（後の尊氏）の嫡男千寿王（後の足利義詮）を加えて鎌倉を攻め、幕府を滅亡させる。