In 1577, in response to Kenshin UESUGI's invasion of Noto-no-kuni and Kaga-no-kuni, Hisahide raised a rebellion again and was shut up within Shigisan Castle.
そして1577年、上杉謙信の能登国・加賀国侵攻に呼応して、再び謀反を起こし信貴山城に立て籠もる。