In the late Kamakura period, the clan had an internal conflict, and after Takatoki HOJO replaced Suenaga ANDO by Suenaga's cousin Suehisa ANDO as Ezo kanrei in 1325, the conflict resulted in a rebellion against the bakufu (Japanese feudal government headed by a shogun, in this case the Kamakura bakufu) (Ezo War).
鎌倉時代末期には一族で争いが起こり、正中(元号)2年（1325年）に北条高時が蝦夷管領を安藤季長から従兄弟である安藤季久に代えると、争乱は幕府への反乱に発展する（蝦夷大乱）。