Kanyaimimi no mikoto, a son of Emperor Jinmu, was the ancestor of the clan and Iotake, a grandson of Kanyaimimi no mikoto, was appointed Shinanonokuni no miyatsuko during the reign of Emperor Seimu.
神武天皇の子の神八井耳命が祖で、成務天皇朝にその孫の五百建命が科野国造に任じられたという。