It is believed that Yamato Takeru no Mikoto is thought to have been buried in Isozaki-jinja Shrine in Omi, and TAKENOUCHI no Nobuzane (武内信實,) a descendant of TAKENOUCHI no Sukune, was sent from Kyoto to Isozaki-jinja Shrine in Omi to take the post of Shinto priest and began to use a family name of Gamo; that was the beginning of the Isozaki family.
この礒崎家は日本武尊の埋葬地と言われる近江の礒崎神社に神官として武内宿禰の後裔、武内信實が京都より派遣され、蒲生姓を名のる。