The power of the Soga clan was significantly diminished by a coup (Isshi Incident, which takes its name from the Zodiacal name of the year the incident occurred and can alternatively called the "Incident of 645.") led by Emperor Tenchi in 645, in which Iruka was assassinated and Emishi prompted to commit suicide.
蘇我氏は、645年の天智天皇、藤原鎌足らのクーデター（乙巳の変）によって、入鹿が暗殺されるとともに蝦夷が自殺するとその勢力は大幅にそがれてしまった。