After that, he defended Azuchi-jo Castle, but when Mitsuhide was killed in the Battle of Yamasaki against Hideyoshi HASHIBA, Mitsuharu is said to have moved to Sakamoto-jo Castle and killed himself.
その後安土城の守備につくが、羽柴秀吉との山崎の合戦で光秀が敗死すると坂本城に移って自害したとされる。