In 1667, the third generation, Shinano no kami (Governor of Shinano Province), Mototomo went mad and killed his wife, the daughter of MIZUNO kenmotsu Tadayoshi of the Mizuno clan in the Yamagata Domain (at the time of this incident, he was the lord of the Okazaki Domain), and was given the sanction of 'kaieki.'
寛文7年（1667年）三代信濃守元知が乱心して妻女である山形藩水野氏水野監物忠善（当時は岡崎藩主）の娘を殺害したため改易となる。