As the domain with roju, troops were dispatched from the Yodo-jo Castle to the Battle of Toba-Fushimi and several persons were recorded as being killed in action, but the domain gave obedience to the Imperial Court due to the conclusion of a secret agreement between the chief executives of the domain and the Imperial Court in Kyoto.
老中を抱える藩として鳥羽・伏見の戦いには淀城より出兵、数名の戦死者を記録するも、藩首脳部と京都朝廷との密約成立により朝廷に恭順。