After Fusatada's death, there was a mutiny when Tamekage NAGAO, who supported Sadazane UESUGI, staged Fusayoshi UESUGI's suicide, then after Tamekage's death, Sadazane UESUGI attempted to regain power with the support of the Date clan, but he was defeated in the Tenbun War and died without an heir, thereby eliminating the family line in 1550.
房定の死後は、上杉定実を擁する長尾為景によって上杉房能が自害に追い込まれるなど下克上され、上杉定実は為景の死後、伊達氏の支援により復権を図るものの天文の乱により挫折し、後継のないまま死去、1550年に断絶した。