In Haibutsukisyaku (the anti-Buddhism movement), that started in the first year of the Meiji period, many temples adopted Omononushi-no-mikoto as their enshrined deity, replacing their Honzon (the principle image of Buddha) that had been worshipped for a long time.
明治初年の廃仏毀釈の際、旧来の本尊に替わって大物主大神を祭神とした例が多い。