In 1573, Takamasa`s younger brother Akitaka HATAKEYAMA was killed by Nobuyori, whereupon Takamasa raised an army and marced on Kawachi Province, but he was defeated and was forced to retreat back to Kii Province.
天正元年（1573年）に弟の畠山昭高が信教に殺されると挙兵し河内に進攻したが、信教に敗北し紀伊に後退する。