After he was strongly impressed with "Rangaku Kaitei" (an introductory book of the Western science study) written by Gentaku OTSUKI, he moved to Edo in 1792 to enter Gentaku's private school Shinrando and began increasing his competence.
大槻玄沢の『蘭学階梯』に感銘を受け、1792年（寛政4年）江戸へのぼり、彼の私塾である芝蘭堂に入門、頭角を現す。