In 1543, Masahira KOBAYAKAWA served in the expedition to Izumo by Yoshitaka OUCHI but was killed at the young age of 21 and his legitimate son Shigehira KOBAYAKAWA took over but Shigehira became blind at a young age.
1543年（天文12年）には、小早川正平が大敗に終わった大内義隆による出雲遠征に従軍して21歳の若さで戦死し、幼い嫡子小早川繁平が後を継いだものの、繁平は幼くして失明する。