Prince Yoshihito's Empress was Seii Taishogun (literally, "great general who subdues the barbarians"), Hidetada TOKUGAWA's adopted daughter, Kame-Hime (Princess Kame) (her real father was Hidetada's nephew and son-in-law, Tadao MATSUDAIRA of Echizen han, Echizen domain); but they did not have a male child, so their nephew, Prince Nagahito, Emperor Mizunoo's prince, was adopted to become the second generation of the court nobility, being so named Hanamachi no miya.
好仁親王は征夷大将軍徳川秀忠の養女・亀姫（実父は秀忠の甥で娘婿にも当たる越前藩松平忠直）を妃としたが嗣子が無かったため、甥にあたる後水尾天皇の皇子・良仁親王が養嗣子として第2代となり、花町宮を名乗った。