However, when a group based in Ishiyama Hongan-ji Temple entered the battles of Noda-jo Castle and Fukushima-jo Castle, Saikashu acted in unison to support the Ishiyama Hongan-ji Temple side, and fought against the army of Nobunaga ODA.
しかし石山本願寺が野田城・福島城の戦いに参戦すると、雑賀衆は一致して石山本願寺につき織田信長軍と戦った。