In 1547, routing Norimasa UESUGI, Kanto Kanrei (the shogunal deputy for the Kanto region), who maintained his influence in the region to some extent, in Otaihara and taking Shiga-jo Castle of the Kasahara clan (located in Saku City), the Takeda clan became to confront the Murakami clan.
天文16年（1547年）には佐久に影響力を残していた関東管領上杉憲政を小田井原で大敗させ、笠原氏の志賀城（佐久市）を落として村上氏と対峙する。