In the Ontate Revolt, together with his son Kagehiro, he supported Kagetora UESUGI and fought Kagekatsu UESUGI; however, Kitajo-jo Castle and other sites fell, Kagehiro was killed, and he retreated to Katsuyori TAKEDA (it is also said that his real father, Takatei, was killed by Kagekatsu).
御館の乱では、子の景広と共に上杉景虎を支持して上杉景勝と戦うが、北条城などを落とされ、景広は戦死し、自身は武田勝頼のもとへ走った（実父とされる高定も景勝に殺害されたといわれる）。