In 1591, one year after the Kasai-Osaki Ikki (the revolt of the former retainers of the Kasai clan and the Osaki clan), Hideyoshi confiscated an additional land of Masamune including Yonezawa and ordered to change his ruling domain to the former Osaki-Kasai domain of 580,000 goku (161,240 cubic meters), which forced Masamune to relocate to the Iwadeyama Castle (present-day, Iwadeyama, Osaki City) as a domain lord.
その年に起きた葛西大崎一揆の戦後処理で翌年の1591年、秀吉に米沢などを更に没収され国替を命じられ、旧大崎葛西領など58万石の領主として岩出山城(現大崎市岩出山)に移った。