Takasato's son, Sadahide (定秀) GAMO served the Rokkaku clan as Syukuro (a chief vassal of a samurai family); however, during the period of Katahide GAMO, the Rokkaku clan was destroyed by the Oda clan; after that, the Gamo clan served the Oda clan and was given important status by the achievements and some occasion including the marriage between Katahide's son Ujisato GAMO and a daughter of Nobunaga ODA; therefore, the Gamo clan at last successfully became Daidaimyo (a feudal lord with a greater stipend) and played important roles during the period of the Oda government and the Toyotomi government.
高郷の子の蒲生定秀は六角氏の宿老として活躍するが、蒲生賢秀の代に六角氏が織田氏に滅ぼされると、蒲生氏は織田氏に属し、賢秀の子である蒲生氏郷が織田信長の娘婿に迎えられるなど重用されたため、織田政権とそれを継承した豊臣政権において蒲生氏は大大名として大きく躍進した。