When Nobunaga ODA backed up the 15th shogun, Yoshiaki ASHIKAGA and drove the Miyoshi clan out from the Kinai region, Akimoto HOSOKAWA served Nobunaga and became the husband of Nobunaga's younger sister, but never retrieved the reins of power in his old days.
織田信長が15代将軍足利義昭を擁立して、畿内から三好氏の勢力を一掃すると、細川昭元は信長に属しその妹婿となったが、昔日の権勢を回復することはなかった。