The Misawa clan was related by blood to the Iwaki clan of the Kameda Domain and the Date clan of the Uwajima Domain, while matrilineal descendants of the Izumo Misawa clan also thrived in Oshu (Northern Honshu, the region encompassing Mutsu and Dewa Provinces).
三沢氏の血は亀田藩岩城氏、宇和島藩伊達氏にも流れており、出雲三沢氏の母系の子孫は奥州でも繁栄した。