In the 1920's, from the Taisho period through the early Showa period, the National Institute of Brewing conducted researches for higher quality sake, and during the course production of sake yeasts for making archetypes of sake which were later developed and spread as Nihonshu ginjo-shu (high-quality sake brewed at low temperatures from rice grains milled to 60 % weight or less) began.
大正時代から昭和時代初頭、1920年代には、国立醸造研究所を中心として、さらに高度な品質の日本酒の開発が模索され、そうした中でのちに日本酒吟醸酒の誕生として普及する酒の原形を醸造する清酒酵母が造られ始めた。