Naosuke II who selected Iemochi as shogun assigned Yoshiyori TOKUGAWA (head of Tayasu-Tokugawa Family) as pro forma Shogun-kokenshoku (guardian) and purged the opposition faction including the Hitotsubashi family, which is called Ansei no Taigoku.
家茂を将軍とした井伊直弼は、徳川慶頼（田安徳川家当主）を形だけの将軍後見職に立てて、一橋派を初めとする反対派の粛清（安政の大獄）に乗り出す。