According to the descriptions from the journal on December 12, 1866 (in old lunar calendar), when the Emperor developed a fever, Tsuneyoshi TAKASHINA, who was in the rank of Emperor's attending doctor (to manage Emperor's daily health), conducted examinations and dispensed drugs for the Emperor but even the next day the Emperor had never got better.
日記の記述よれば、孝明天皇が発熱した12日、天皇の執匙（天皇の日常健康管理を行う主治医格）であった高階経由が拝診して調薬したが、翌日になっても病状が好転しなかった。