In order to defeat Nobunaga, Yoshiaki issued directions to defeat Nobunaga to Nagamasa ASAI, Yoshikage ASAKURA, Shingen TAKEDA, Kennyo HONGANJI, and Miyoshi sanninshu (three chief retainers of the Miyoshi clan) to form a league and lay a siege to Nobunaga, and opposed Nobunaga.
そして義昭は信長を討伐するため、浅井長政や朝倉義景、武田信玄、本願寺顕如、三好三人衆らに信長討伐令を発して信長包囲網を結成し、信長と敵対することとなる。