The temple was initially located in front of Zao-do Hall in Kinpusen-ji Temple and was referred to as Mitsujo-in Temple, but it was renamed 'Sakuramoto-bo' when the separation of Buddhism and Shintoism took place in 1868.
もとは金峯山寺の蔵王堂の前に在って密乗院と称していたが、明治初年の神仏分離の際に「桜本坊」と改称された。