In 1576, after the death of Naomasa BAN, commander of the battle to capture Hongan-ji Temple, Nobumori assumed the role of commander, and his cohorts which included yoriki (mounted warriors) received from seven Kinai provinces were the biggest among those of the Oda family, but the battle was deadlocked because of the strong resistance from Hongan-ji Temple.
天正4年（1576年）には、本願寺攻略戦の指揮官である塙直政の戦死を受け、後任として対本願寺戦の指揮官に就任、畿内7ヶ国の与力をつけられた信盛配下の軍団は、当時の織田家中で最大規模であったが、本願寺の熾烈な抵抗もあって戦線は膠着した。