The Takum-Uesugi family declined early, and the Inukake-Uesugi family dropped out from the main lineage after the Uprising of Zenshu UESUGI, therefore, from the mid-15th century the 2 families of the Yamanouchi-Uesugi, descendants of Noriaki, and the Ogigayatsu-Uesugi, descendants of Noriaki's cousin, became dominant, with the Kanto Kanrei position being dominated by the head of the Yamanouchi-Uesugi family.
宅間上杉家は早くに衰え、犬懸上杉家は上杉禅秀の乱により主流派から脱落したので、15世紀半ばからは憲顕の子孫山内上杉家と、憲顕の従兄弟の子孫扇谷上杉家の2家が有力となるが、関東管領の職はもっぱら山内上杉家の当主が独占した。