Although when Nagamasa ASAI had once a military agreement with Nobunaga ODA and drove out the Rokkaku clan, later Nagamasa, joining the Shogun's alliance against Nobunaga, fought against Nobunaga and was defeated in 1573.
織田信長と結んだ浅井長政に至って六角氏を駆逐するが、後に将軍の信長包囲網に加わって信長に抵抗、1573年に滅亡する。