In 1360 he was awarded Shugoshiki of Ise Province position, so Yoriyasu became the Shugo of three important provinces in Tokai-do Road and the Toki clan enjoyed the most prosperous time.
延文5年（1360年）に伊勢国守護職を与えられ、頼康は東海道の要衝3ヶ国の守護を兼ねて土岐氏の最盛期を築き上げた。