Subsequently, however, Nobushige YODA, who was on Ieyasu's side, was killed in battle in the northern region, and Masayuki SANADA, a former vassal of Takeda who had also served under Nobunaga ODA, resided in the newly built Ueda-jo Castle, resisting the rule of the Tokugawa clan with the support of the Uesugi clan.
しかし、その後北部では家康に従う依田信蕃が戦死し、武田旧臣で、一時は織田政権に臣従した真田昌幸が新たに築城した上田城に拠り、上杉氏の援助を得て徳川氏の支配を拒んだ。