In 1509, he built Johei-ji Castle and became lord of the castle and, after the death of Ienobu KAMISAKA he relied upon Ienobu's heir Nobumitsu KAMISAKA for support, but in 1523, the individual in line to be Takakiyo's successor, his eldest son Takanobu KYOGOKU, came under pressure by Sadanori ASAMI and Sukemasa AZAI, so Takakiyo promoted the interests of his younger son, Takayoshi KYOGOKU (Takatsugu KYOGOKU's father), the families became divided regarding Nobumitsu, and the following year, headed towards conflict, Takakiyo and his losing counterparts escaped to Owari.
1509年（永正6年）には上平寺城を築いて居城とし、上坂家信の死後は家信の後を継いだ上坂信光を頼っていたが、1523年（大永3年）に、高清の後継を巡って、長男の京極高延を押す浅見貞則、浅井亮政らと、次男の京極高吉（京極高次の父）を推す高清、信光らに家中は分かれ、翌年には戦いへとおよび、敗れた高清らは尾張へと逃れる。