In June 1582, Tadaoki's father-in-law Mitsuhide AKECHI instigated the Honnoji Incident and called upon Tadaoki and his father Fujitaka to provide support however, but they refused and Tamako was imprisoned in Midono in Tango Province (vicinity of present-day Sugawa, Yasaka-cho, Kyotango City).
天正10年（1582年）6月、岳父・明智光秀が本能寺の変を起こし藤孝・忠興父子を味方に誘ったが、父子は誘いを拒否したうえ、玉子を丹後国の味土野（現在の京丹後市弥栄町須川付近）に幽閉した。