Takakazu served both Tsunashige TOKUGAWA and Tsunatoyo TOKUGAWA (Ienobu TOKUGAWA) of the Kofu domain in Kai Province (modern-day Kofu City, Yamanashi Prefecture) and became the Kanjoginmiyaku (a post within the Edo shogunate, whose duty was to support commissioners at the finance ministry).
甲斐国甲府藩（山梨県甲府市）の徳川綱重、徳川綱豊（徳川家宣）に仕え，勘定吟味役となる。