The eldest son Takanobu succeeded as the heir, but she struggled in conflicts with her father-in-law Shigenobu, who attended once again to government affairs as Tadanobu's guardian, and in coping with the Edo bakufu (Japanese feudal government headed by a shogun), which treated Christians and the Matsura clan sternly.
長男・隆信が跡目を相続したものの、後見として再び政務を取り始めた舅・鎮信との対立や、キリシタン及び松浦氏に厳しい目を向ける江戸幕府との間で対応に苦慮することとなる。