As a man of mature years Tomoteru TAKAYAMA served Hisahide MATSUNAGA, who was a senior vassal of Nagayoshi MIYOSHI, who had assumed control over Kinai region (the five capital provinces surrounding the ancient capitals of Nara and Kyoto: Yamashiro, Yamato, Kawachi, Izumi and Settsu).
壮年期には、畿内の実権を握る三好長慶の重臣であった、松永久秀に仕えた。