He was initially considering taking part in the Eastern squad in the Battle of Sekigahara in 1600, but the Western squad wielded their influence on Ise, he and his younger brother Yukitsugu UJIIE were forced to take part in the Western squad.
慶長5年（1600年）の関ヶ原の戦いでは、当初は東軍に与しようとしていたが、伊勢に西軍の勢力が及んできたため、やむなく弟の氏家行継とともに西軍に与することとなった。