The temple was besieged during the Ishiyama War by Nobunaga ODA and after a decade-long battle, the chief priest of the sect, Kennyo, under attack from Nobunaga, made a peace settlement with him in 1580.
織田信長との石山戦争では篭城戦を行ったが、10年に及ぶ戦闘の後、信長の攻勢に、1580年門主顕如は和睦。