Sadako was born weak and died when she was twenty three years old, after two years of the marriage, while Imperial Prince Taruhito was away to Fukuoka, the Prince remarried, in July 1873, with the head of the former Lord of Echigo Shibata Domain, Naohiro MIZOGUCHI's adopted daughter, Tadako. (the oldest son of the Lord of Ise Kobe Domain, Tadahiko HONDA's daughter.)
しかし、病弱であった貞子は婚儀の2年後、熾仁親王の福岡赴任中に23歳の若さで死去したため、明治6年7月に旧越後新発田藩主・溝口直溥の養女・董子（＝ただこ、伊勢神戸藩嫡子・本多忠穆の娘）と再婚した。