However, according to the wish of her brother Masamoto HOSOKAWA, she returned to secular life and married Harima no kuni shugo (provincial constable of Harima Province) Masanori AKAMATSU as his second wife when she was 30, 31, or 33 years old.
しかし、弟の細川政元の意向により還俗して、明応2年4月20日（1493年5月5日）、30歳、31歳もしくは33歳で播磨国守護・赤松政則の後添えとして嫁ぐ。