But, a serious incident occurred -- In collusion with Yoshioki OUCHI, Takakuni HOSOKAWA fled from Kyoto on April 27, 1508 on the pretext of visiting Ise Shrine and took refuge with Iga no kuni Shugo (Provincial Constable of Iga Province) Takanaga NIKI.
しかし細川高国は逆に大内義興らと気脈を通じ、永正5年（1508年）3月17日伊勢参宮と称して京都を脱出、伊賀国守護の仁木高長に身を寄せるという大事件がおきた。