At the time Yoshimune started the reform, the cultural center of Japan including the herbalism study ground was still in Kyoto, which had not been changed yet since the establishment of Edo bakufu (Japanese feudal government headed by a shogun).
この時はまだ、江戸幕府開幕後も日本の文化中心地は京都であり本草学の中心地もまた京都であった。