There appeared some Uchi-kanrei whose political power overshadowed the regents and the Tokuso family; for example, Yoritsuna destroyed Yasumori ADACHI, a senior vassal, in the Shimotsuki Incident and unleashed a reign of terror, or Takatsuna (Enki) NAGASAKI and his son Takasuke NAGASAKI ruled with tyranny in the time of Takatoki HOJO.
頼綱が有力御家人の安達泰盛を霜月騒動で滅ぼして恐怖政治を敷いたり、北条高時の時代に長崎高綱（円喜）・長崎高資父子が専横を極めたように、内管領には執権や得宗を凌駕する者も現れた。