In June 1738, the kaisho was abolished because the quality of the materials improved as drug traders such as wholesale drug companies or drug sellers learnt to recognize genuine products; however, the true reason is said to be that there was a strong backlash from the traders against the possibility of the control of medicinal material distribution by Wayakushu aratame kaisho.
元文3年（1738年）5月(旧暦)に薬種問屋・薬種屋ら薬種業者が真物を覚えて品質が向上したことを理由に廃止されたが、実際は薬種流通の統制につながる和薬種改会所に対して業者の反感が強かったからと言われている。