Akizane UESUGI (a son of Shigeuji ASHIKAGA) had succeeded the post of Kanto Kanrei in accordance with a will of Akisada, but Norifusa disputed and won to succeed the reign of the Yamanouchi-Uesugi clan in 1512 and also succeeded the post of Kanto Kanrei at Akizane's death in 1515.
関東管領職は顕定の遺言により上杉顕実（足利成氏の子）が継いでいたが、憲房はこれと争って勝利し、1512年に山内上杉氏の家督を継ぎ、1515年の顕実の死によって関東管領職をも継いだ。