After Mitsuaki's days were over, the Irako family was divided in two family lines (Kendosai and Sen no do) but the both families succeeded to Irako-style surgery, and till they encountered the Meiji Restoration in the days of Mitsuoki IRAKO and Mitsunobu IRAKO, respectively, they had served chotei (the Imperial Court) as goteni (a doctor who is hired by bakufu [Japanese feudal government headed by a shogun] or daimyo [a feudal lord]).
光顕以後、伊良子家は二家（見道斎・千之堂）に系統が分かれるが、両家とも伊良子流外科を継承し、それぞれ伊良子光順・光信の時代に明治維新を迎えるまで、御典医として朝廷に仕えた。