When Takauji rebelled against the Kenmu government after the Nakasendai Rebellion, the Hosokawa clan followed Takauji and was dispatched to Shikoku when Takauji's army retreated to Kyushu.
中先代の乱を契機に尊氏が建武政権から離反すると細川氏も従い、九州へ落ちる際には四国へ分遣される。