Further, as it is the rare Nyorai that presides over worldly interests, many typical (in charge of praying to defend and maintain the nation) Esoteric Buddhism temples, such as Enryaku-ji Temple, Jingo-ji Temple, To-ji Temple and Kanei-ji Temple, enshrine Yakushi Nyorai as their principal image.
また、現世利益を司る数少ない如来である事から、延暦寺、神護寺、東寺、寛永寺のような典型的な(国家護持の祈りを担う)密教寺院においても薬師如来を本尊とするところが多い。