During mid-Ming Dynasty, O Shujin (priestly name was Yomei) presented a new interpretation of 'Kakubutsu Chichi' (Kakubutsu leads to maximum activation of wisdom) in "Daigaku" (a book describing educational philosophy of Daigaku), which Chu His set forth as a way of attaining law.
明代中期、王守仁（号は陽明）は、朱熹が理を窮めるために掲げた方法の一つである『大学』の「格物致知」について新しい解釈をもたらした。