In the same year, when local lords in Shinano Province such as Yoshikiyo MURAKAMI, Masayori TAKANASHI (Kagetora's uncle) and so on who were disposed of their territories due to the invasion of Shinano Province by Harunobu TAKEDA in Kai Province and escaped to Kagetora with the hope of reinstatement of their territories, Kagetora dispatched troops to Shinano Province in response to the request in September and confronted Harunobu at Kawanakajima (southern surburb of Nagano City) (the first Battle of Kawanakajima).
同年、甲斐国の武田晴信の信濃侵攻によって領地を追われた村上義清・高梨政頼（景虎の叔父）らの信濃国人が領地復権を望んで景虎のもとへ逃亡してくると、8月にはこれに応じて信濃に出兵し、川中島（長野市南郊）で晴信と対峙する（第1次川中島の戦い）。