When the domain of the Hosokawa family was transferred, the family of Nagasada moved to Kumamoto City; however, the fact that the family of Nagasada was Christian was reported to bakufu through the Nagasaki magistrate that received the information from a betrayer--after all, Nagasada was martyred with his family and followers in Zenjoji Temple in Kumamoto on January 30, 1636.
細川家の移封に従い熊本市に移るが、長崎奉行への密告があって幕府に露見したため、寛永12年12月22日（1636年1月30日）、熊本禅定寺において家族・従者と共に殉教した。