However, after Shingen TAKEDA, who had been the strongest enemy of Nobunaga, died from a disease in April 1573, a counterattack of the Oda army began, and in July, his brother-in-law, Yoshiaki ASHIKAGA, was expelled from Kyoto; thus the Muromachi shogunate came to an end.
しかし元亀4年（1573年）4月、信長最大の強敵であった武田信玄が病死すると、織田軍の反攻が始まり、7月には義兄にあたる足利義昭が信長によって京都から追放され、室町幕府は滅んだ。