In 1580 he attacked Nagaharu BESSHO, who was a lord of Harima Miki Castle and rose in revolt ODA clan, and defeated him by starving strategy for two years, although he lost important vassals such as Hanbei TAKENAKA and Sigenori FURUTA (the battle at Miki) in the middle of the battle.
天正8年（1580年）には織田家に反旗を翻した播磨三木城主・別所長治を攻撃、途上において竹中半兵衛や古田重則といった有力家臣を失うものの、2年に渡る兵糧攻めの末、降した（三木合戦）。