The Incident of Honkoku-ji Temple, on January 31, 1569, was an attack of Miyoshi sanninshu (three chief retainers of the Miyoshi clan) on Yoshiaki ASHIKAGA, seii taishogun (literally, "great general who subdues the barbarians") of the Muromachi bakufu (Japanese feudal government headed by a shogun), who was in his temporary residence (Rokujo Palace) in Kyoto Honkoku-ji Temple (it was called 'Honkoku-ji' then).
本圀寺の変（ほんこくじのへん・本國寺の変）とは、永禄12年1月5日(旧暦)（1569年1月21日）に三好三人衆が京都本圀寺（当時の呼称は「本國寺」）に仮の御所（六条御所）を置いていた室町幕府征夷大将軍・足利義昭を襲撃した事件。