In 1333, during the late Kamakura period, when the Genko Rebellion occurred as a result of an anti-shogunate movement led by Emperor Godaigo, the Hosokawa clan joined the army of Takauji ASHIKAGA.
鎌倉時代後期の1333年(元弘3)に後醍醐天皇の討幕運動から元弘の乱が起こると、細川氏は足利尊氏の挙兵に参加している。