Higashi Koya-kaido road parted from Kyo-kaido road (Osaka-kaido road) at Yahata (Yahata City, Kyoto Prefecture), ran through the eastern part of Kawachi Province, and joined Nishi Koya-kaido road at Nagano (Kawachi-nagano City, Osaka Prefecture).
八幡（京都府八幡市）で京街道(大坂街道)と別れ、河内国の東部を通り、長野（大阪府河内長野市）で西高野街道と合流し、