He later was employed as an apprentice domain doctor with a salary of 50 koku (13.9 cubic meters), and in 1823, Genpo accompanied the lord of the domain to visit Edo and started to study Western studies under Genshin UDAGAWA.
やがて高50石御小姓組御匙代にすすみ、文政6年（1823年）には、藩主の供で江戸に行き、宇田川玄真の門に入り、以後洋学の研鑚を重ねる。