In the early Sengoku period (Period of Warring States in Japan), Sadahide (貞秀) GAMO strongly supported Shugo (provincial military governors) Takayori ROKKAKU to make the Rokkaku clan one of powerful Sengoku daimyo (Japanese territorial lord in the Sengoku period); however, Sadahide's heir Hideyuki died young and before naming the new heir, Sadahide died, therefore, a conflict arose between Hideyuki's oldest son Hidenori GAMO and Sadahide's son Takasato GAMO.
戦国時代(日本)の初期の蒲生貞秀は、守護の六角高頼をよく補佐し、六角氏の戦国大名化に貢献したが、嫡男の秀行が早世したため、その死後に嫡孫の蒲生秀紀と子の蒲生高郷との間に争いがおきた。