According to the condition certificate that the doctors of the Bureau of Medicine residing in Edo and the interior doctors of the shogunate prescribed, symptoms that seemed to be beriberi such as 'iresomeness and rough blood flow', 'heartache', 'urinary incompetence', 'moisture' and 'hands and feet paralysis' were recorded.
江戸に常駐していた典薬寮医師や幕府の奥医師たちが発行した容態書には、「御気血御不順」「御心痛」「御小水不利」「水気」「御手足麻痺」など、脚気と思われる症状が記されている。