Kenshin UESUGI based himself in Echigo and expanded his territory into Kanto and the Hokuriku Region, but after his death, a fight to become the head of the family (Otate War) developed between his two adopted sons, Kagekatsu UESUGI and Kagetora UESUGI, and because of this turmoil they lost their territories in the Kanto Region.
上杉謙信は、越後を拠点として領国を関東と北陸地方に拡大したが、その死後、二人の養子上杉景勝と上杉景虎の間で家督争い（御館の乱）が起こり、この混乱によって関東地方の領国を喪失した。