Motoharu and Kagetaka participated in the siege around Nobunaga to fight against the Oda army in the Sanin (mountain provinces behind the Sanyo or Inland Sea provinces) and the Sanyo (Inland Sea provinces), respectively.
元春が山陰、隆景が山陽を担当し、信長包囲網の一角として織田方と戦うこととなる。