The gyaku-en indicates the concept of not believing in the teachings of Buddha (i.e., defying the 'en', or connection with Buddha) unquestioningly or someone who can not be saved.
逆縁（ぎゃくえん）とは、仏の教えを素直に信じない（縁に背く）こと、またはそのような救い難い人をいう。