The Mimasaka-kaido road was branched from the Saigoku-kaido road (Sanyo-do road) slightly west of the Himeji-jo Castle town towards the northwest direct, reaching the area of Tsuyama-jo Castle town in Mimasaka Province.
美作街道は姫路城の城下町のやや西で西国街道（山陽道）から分岐し、北西に伸びて美作国津山城下に達する。