The Hojo clan, who had an amicable relationship with the Oda clan, invaded Oda's territory Ueno with army 56,000 strong led by Ujinao HOJO, defeated the army 20,000 strong lead by Kanto Kanrei (A shogunal deputy for the Kanto region) Kazumasu TAKIGAWA, one of the big four of Oda, at the Battle of Kannagawa River, and Kazumasu TAKIGAWA was routed to his home ground Ise.
織田家と友好関係だった北条家が、北条氏直率いる5万6,000の兵で織田領上野に侵攻し、織田四天王の１人で関東管領・滝川一益率いる２万を神流川の戦いで撃破し、滝川一益は本拠地の伊勢まで敗走する。