On September 19, 1862, Hisamitsu started from Edo after the Imperial envoy achieved his aim to going to Edo, but on the way to Kyoto on Tokai-do Road his procession met with four English citizens at the Namamugi Village, Musashi Province (present Tsurumi Ward, Yokohama City, Kanagawa Prefecture), and following feudal retainers of Satsuma killed and injured them because they obstructed Hisamitsu's procession (the Namamugi Incident).
勅使東下の目的を達成したことで8月21日、久光は江戸を出発、東海道を帰京の途上、武蔵国橘樹郡生麦村（現神奈川県横浜市鶴見区(横浜市)）でイギリス民間人4名と遭遇、久光一行の行列の通行を妨害したという理由で随伴の薩摩藩士がイギリス人を殺傷する生麦事件が起こる。