In 1544, in order to get Yorizumi TOKI (the legitimate son of Yoritake TOKI), who had escaped into Echizen Province, appointed as Shugo (Governor) of Mino Province, Takakage enlisted the help of Nobuhide ODA from Owari Province and attacked Dosan SAITO and Yorinari TOKI of Mino Province, then proceeded to burn down the town surrounding Inokuchi-jo Castle (Inabayama-jo Castle).
天文13年、越前に逃れてきていた土岐頼純（土岐頼武嫡男）を美濃守護とするため、尾張の織田信秀と共闘し、美濃の斎藤道三および土岐頼芸を攻め、井口城（稲葉山城）下を焼き払う。