During the Period of the Southern and Northern Courts, Shigefusa's grandson, Norifusa UESUGI, whose younger sister, Kiyoko UESUGI, was Takauji and Tadayoshi ASHIKAGA's mother, was assigned as Shugo (governor) of Kozuke Province as a reward for helping Takauji, and he fought against the Southern Court supporters, the Nitta clan, in the Kanto Area.
南北朝時代(日本)、重房の孫・上杉憲房は妹の上杉清子が足利尊氏・足利直義兄弟の母であったことから尊氏を助けて功績を立て、上野国の守護に任ぜられて関東地方で南朝方の新田氏と戦った。