In 1416 during the days of the fourth Shogun Yoshimochi ASHIKAGA, the War of Zenshu UESUGI occurred, where the former Kanto Kanrei Zenshu Uesugi (Zenshu) raised an army against Mochiuji ASHIKAGA, the fourth Kamakura Kubo.
4代将軍足利義持時代の1416年（応永23年）には前関東管領の上杉禅秀（禅秀）が4代鎌倉公方足利持氏に反して挙兵する上杉禅秀の乱が起きた。