In July of that year, Ieyasu, who returned to Hamamatsu and got to know about the rebellion of Masayuki, started the subjugation of Sanada and sent an army about 7,000 strong including his vassals Mototada TORII, Tadayo OKUBO, and Chikayoshi HIRAIWA to the base of the Sanada clan, Ueda-jo Castle.
同年7月、浜松に帰還した家康は昌幸の造反を知ると八月に真田討伐を起こし、家臣の鳥居元忠、大久保忠世、平岩親吉ら約7000の兵を真田氏の本拠・上田城に派遣する。