It is said that she had a very lonely newly-married life because Yoshinobu was very intimate with Tsuneko TOMENOMIYA, a widow of Yoshihisa TOKUGAWA, and also because her engagement to Yoshinobu had been determined as a replacement on very short notice.
慶喜との婚約自体が、代役として急遽決められた物であった上、慶喜は徳川慶壽未亡人・東明宮直子（とめのみやつねこ）女王と大変に仲が良かったため、美賀子は非常に寂しい新婚生活を送ったと言われる。