During the Muromachi period, the Misawa clan became affiliated with the Yamana clan, then ruler of Izumo Province, and accompanied Mitsuyuki YAMANA, who was a provincial constable of Izumo Province, to fight in the Meitoku War in 1391.
室町時代には出雲国を支配していた山名氏の傘下に入り、1391年には出雲守護山名満幸に従って明徳の乱に出陣。