There being little time for restructuring his own administration, on June 13, eleven days after Honno-ji no Hen, in Oyamazaki-cho, which stretched over present Oyamazaki-cho in Kyoto Prefecture and Shimamoto-cho in Osaka Prefecture, Mitsuhide had to intercept Hideyoshi TOYOTOMI's army, which had reconciled itself with the Mori clan on hearing of the incident and returned from Chugoku region (Battle of Yamazaki).
そしてみずからの新政権の統制を整備する間も無く、本能寺の変から11日後の6月13日（西暦7月2日）、変を知って急遽毛利氏と和睦し、中国地方から引き返してきた豊臣秀吉の軍を、現在の京都府大山崎町と大阪府島本町にまたがる大山崎町にて迎撃した（山崎の戦い）。