Influenced by Nanmei KAMEI, he enrolled in a government-backed school operated by Kien MINAGAWA and immersed himself in writing the book "Genen" (Fundamental Flow), whereby he criticized the old-fashioned medicine based on Onmyo-gogyo-setsu (Chinese traditional pseudo-science built on five elements).
安永6年（1777年）亀井冥南の影響で皆川淇園の家塾に入門し、『元衍』の著述に専念、陰陽五行説に基づく旧態医学を批判。