When the Eikyo War broke out, the Kamakura kubo entered into conflict with the Kantokanryo as well, and after losing the battle in 1439, the fourth Kamakura kubo Mochiuji ASHIKAGA was defeated and ordered to commit suicide leading to the post being temporarily discontinued.
永享の乱の際には関東管領とも対立し、第4代鎌倉公方足利持氏が敗れ、1439年に自害させられたことで一旦断絶した。