In 1568, with Yoshiaki ASHIKAGA, brother of the former shogun Yoshiteru ASHIKAGA as his lord, Nobunaga successfully banished and subdued Miyoshi and Matsunaga and their administration which had been in power in Kyoto.
永禄11年（1568年）には前将軍・足利義輝の弟・足利義昭を奉じて上洛し、それまで京都にて政権を確立していた三好・松永政権を追放・屈服させることに成功した。