During the Warring States Period, they served Ujitsuna HOJO and, after the decline of the Gohojo clan, they used the name Takuma-Uesugi family and became Ieyasu TOKUGAWA's hatamoto.
戦国期には北条氏綱に降り、後北条氏滅亡後は宅間上杉家を名乗り、徳川家康の旗本となった。