Until the time of Masayori TAKANASHI, a grandson of Masamori, the Takanashi clan remained independent, but Shingen TAKEDA, of Kai Province, who had destroyed the Murakami clan, invaded the land of the Takanashi clan and they retreated to the Iiyama area close to the boundary of Shinano and Echigo from Nakano, the base, between 1555 and 1558.
それでも政盛の孫の高梨政頼の頃まで独立性を保ってきたが、村上氏を撃破した甲斐国の武田信玄の侵攻を受け、弘治(日本)年間（1555-1558）に本拠地中野郷から信越国境に近い飯山郷まで後退した。