The Mera clan had strong connections militarily, politically as well as economically, with adjacent clans that shared boundaries with its territory, such as the Hitoyoshi clan in Higo Province, clans in Hyuga Province, and the Satsuma clan.
米良氏は軍事的・政治的・経済的に肥後国人吉藩、日向国諸藩、薩摩藩など領境を接する諸藩と強いつながりを持っていた。