As pufferfish have poison in their internal organs (it is widely known that tiger puffer, which are recognized as an upmarket fish, have tetrodotoxin inside while trunkfish have puff toxin) it is difficult to deal with the fish.
フグはその内臓などに毒（高級魚とされるトラフグなどにが体内に持つのはテトロドトキシンが広く知られている。またハコフグが持つパフトキシンもある）を持つため扱いが難しい。