While the Miyoshi's government kept having the internal conflict, the younger brother of Yoshiteru, Yoshiaki ASHIKAGA, who was on the run with the support by vassals such as Yusai HOSOKAWA due to the Eiroku Incident, gained support by Nobunaga ODA, who governed the Owari Province and the Mino Province and was on a roll, and headed to Kyoto in September 1568.
このように三好政権内部で内紛が続いている中、永禄の変で細川幽斎ら幕臣の援助を受けて逃亡していた義輝の弟・足利義昭は、尾張国・美濃国を領して勢いに乗る織田信長の援助を受け、永禄11年（1568年）9月に上洛を開始する。