Yoriyuki HOSOKAWA's wife was a daughter of Hose JIMYOIN (持明院保世) and became the wet nurse of the third Seii Taishogun (literally, "great general who subdues the barbarians") of Muromachi bakufu Yoshimitsu ASHIKAGA, and so it is thought that his own child, who would have been the same age as Yoshimitsu, died in early.
妻は持明院保世の娘で、室町幕府3代征夷大将軍足利義満の乳母となっているため、義満と同年代の実子が早世していると考えられている。