In 1465, due to a conflict between Rennyo, who had succeeded the Hongan-ji Temple, and Enryaku-ji Temple, which was the main temple, religious persecution occurred during the Kansei era and Otani Hongan-ji Temple was destroyed.
寛正6年（1465年）、本願寺を継承した蓮如と本寺である延暦寺の対立から大谷本願寺が破壊されるという寛正の法難が発生する。