Shogun Yoshiteru observed these events and resolved, even as he accepted the support of Sengoku daimyo families closely allied with the Shogun, especially Kenshin UESUGI (the Kanrei of the Kanto region), to try to wrest back the power and prestige of the office of Shogun, only to be assassinated during a coup d'etat (known as the Eiroku Incident) by the faction led by Matsunaga, who was the primary target of Yoshiteru's efforts.
この状況を見た将軍・義輝は上杉謙信（関東管領）をはじめとする親将軍家の戦国大名の支援を受けながら、将軍権威の再建に努めるが、その矢先松永一派のクーデター（永禄の変）によって暗殺された。