During the Daiei era (1521-1528) the battles against external forces became severer and in 1524, Nobutora joined the battle between the both Uesugi clans and the emerging power of the Hojo clan in the Kanto region and fought against the Hojo force around the border of Sagami Province and Kai Province in Tsuru County.
大永年間には対外勢力との抗争が本格化し、大永4年（1524年）には、関東における両上杉氏と新興勢力の北条氏の争いに介入し、都留郡の甲相国境付近では相模国境で北条勢と争った。