In addition, "Agechi-rei" (the decree he was going to implement for national defense, whose contents were to take away the territory of 'daimyo' and 'hatamoto' in Edo and Osaka) caused fierce resistance of "daimyo" and merchants, so Shogun Ieyoshi himself was made withdraw the decree and Mizuno lost his position, when Tenpo Reforms ended with a span of just two years.
また、国防上の必要性から江戸・大坂の大名・旗本領を幕府に召し上げようとする上知令を推進しようとしたところ、大名・商人らの猛反撥を招くこととなり、将軍家慶自ら撤回を命ずる事態となり、水野は失脚し、天保の改革はわずか2年にして崩壊した。