When Masamoto HOSOKAWA was assassinated in 1507, Yoshitada plotted to return to the Shogunate and, supported by Yoshioki OUCHI, Takakuni HOSOKAWA and several daimyo from western Japan and Kyushu, he returned to Kyoto in April 1508, deposed Yoshizumi and was reappointed as the Shogun (the Eisho Disturbance).
永正4年（1507年）に細川政元が暗殺されると、義尹は将軍への復帰をもくろみ、永正5年（1508年）4月に大内義興や細川高国の支援を得て中国地方や九州の諸大名と共に上洛し、義澄を廃して再び将軍になった（永正の錯乱）。