Due to his achievements, he was transferred to Kuwana Domain, Ise Province (present Kuwana City, Mie Prefecture) with 100,000 koku (another theory holds that it was 150,000 koku) in 1601, and the former territory in Otaki was given to his second son Tadatomo HONDA with 50,000 koku as a branch family.
この功績により、慶長6年（1601年）、伊勢国桑名藩（現在の三重県桑名市）10万石（一説に15万石）に移されると、それまでの大多喜領は次男・本多忠朝に別家5万石で与えられた。