In 1333, when a senior vassal named Takauzi ASHIKAGA who had been dispatched to Kyoto to eliminate the anti-bakufu forces defected to the Godaigo faction and deposed the Rokuhara Tandai, Yoshisada NITTA raised an army in Kozuke Province and with Kanto gokenin, who agreed to this, captured Kamakura and thus overthrew the Kamakura bakufu and the Hojo clan (Genko War).
1333年（元弘3/正慶2）、反幕府勢力の討伐のために京都へ派遣された有力御家人の足利尊氏が、一転して後醍醐側へつき六波羅探題を落とすと、新田義貞が上野国で挙兵し、これに呼応した関東の御家人たちと鎌倉を攻略して、鎌倉幕府と北条氏は滅亡した（元弘の乱）。