In 1871, she started in practice in Tsukiji, Tokyo, thanks to the supported given by her paternal half-brothers (older brother, Alexander von Siebold and younger brother Heinrich von Siebold), and she was appointed Goyo-gakari (a general official of the Imperial Household) of the Imperial Household Ministry, as her medical skill was highly evaluated.
1871年（明治4年）、異母弟にあたるシーボルト兄弟（兄アレクサンダー・フォン・シーボルト、弟ハインリッヒ・フォン・シーボルト）の支援で東京は築地に開業したのち、宮内省御用掛となるなど、その医学技術は高く評価された。