In 1582, Takatsugu was expelled after Mitsuhide AKECHI was defeated and killed because he provoked Hideyoshi's wrath by reason that he was on the side of Mitsuhide in the Honnoji Incident.
天正10年（1582年）、本能寺の変において明智光秀に与したために光秀の敗死後に秀吉の怒りを買って追放された。