Later when the shogun Yoshiaki conflicted with Nobunaga and the anti-Nobunaga network was laid, Yoshitsugu and sanninshu took Yoshiaki's side and conflicted with Nobunaga.
後に、将軍・義昭と信長が対立し、将軍・義昭によって信長包囲網が敷かれると、義継や三人衆は義昭について信長と対立する。