In 1853, with the recommendation of Tsunetami SANO, Hisashige assumed the post of 'Seiren gata' (a research and development section of advanced technologies) in the Saga Domain, Hizen Province which area was ruled by a Western-studies geek, Naomasa NABESHIMA, where Hisashige succeeded in building Japan's first models of a steam locomotive and a steamboat.
嘉永6年（1853年）、佐野常民の薦めで蘭学狂いと言われた鍋島直正が治める肥前国佐賀藩の精煉方に着任し、国産では日本初の蒸気機関車及び蒸気船の模型を製造。