There are many branch families of the Uesugi clan, and the following lineages that branched out during the generations of the sons of Yorishige UESUGI and Norifusa UESUGI are the most well-known.
上杉氏には数多くの分家があり、上杉頼重、上杉憲房の子息の代で分かれた以下の系統が著名である。