However, in the Sengoku Period (Period of Warring States), the family suffered consecutive invasions by the Kono clan of the eastern Iyo Province, the Tosa-Ichijo clan of Tosa Province, the Otomo clan of Bungo Province in Kyushu, and the family's influence gradually declined.
戦国時代に入ると、伊予東部の河野氏や、土佐国の土佐一条氏、九州豊後国の大友氏の侵攻に遭って次第に衰退していった。