In the case of Osaka, for which relatively many data remain, there were three main warehouse merchants serving as Todori (chiefs) of the kaisho, who took turns in supervising officials of the kaisho, and under them, there were 121 people belonging to Yakushuya nakama (the union of drug sellers), who were divided into groups by basically three people (40 groups in total) and worked at the kaisho every other day as the officials to conduct inspection and collect aratameryo.
比較的資料が残っている大坂の例を取ると、主たる問屋3名が会所頭取となり交替で会所役人を指揮し、その下に薬種屋仲間に属する121名が原則3名1組として1日交替（全40組）で会所に詰めて会所役人として検査及び改料徴収の任務を行った。