Therefore, in 1549 he was reconciled with the Saito family by the strategic marriage between his son Nobunaga and Dozan SAITO's daughter Nohime, but as the confrontation with the Imagawa clan still continued and afflicted him, he suddenly died by epidemic disease in Suemori-jo Castle (Owari Province) in April 18, 1551.
そこで天文18年（1549年）、子の信長と斎藤道三の娘・濃姫を政略結婚させることで斎藤家とは和睦したものの、今川氏との対立はなおも続き苦しめられつづける中、天文20年（1551年）3月3日、流行病により末森城(尾張国)で急死した。