The Ii Tairo's policy to prevent the Imperial Court from taking initiatives in politics by removing the coalition of dominant clans from government in favor of the Shogunate government failed, and, not only that, but the authority of the Shogunate had begun to fade, leading to the escalation of the Sonno Joi Movement (the movement that supported the Emperor and the expulsion of foreigners).
井伊大老が試みていた、幕政を雄藩との協調体制から幕閣主導型に回帰させ、朝廷の政治化を阻止する、という路線が破綻したばかりか、幕府の権威も失墜し、幕末の尊王攘夷運動が激化する端緒となる。