That September, as supreme commander he led warlords (including Hideyoshi TOYOTOMI and Mitsuhide AKECHI, whose forces formed the vanguard) in the Battle of Shigisan-jo Castle in Yamato Province, defeating their enemies, Hisahide MATSUNAGA and Hisamichi MATSUNAGA, father and son.
8月には再び反逆した松永久秀討伐の総大将となり、明智光秀を先陣に豊臣秀吉ら諸将を率い、松永久秀・松永久通父子が篭城する大和信貴山城を落とした（信貴山城の戦い）。