Once the Sengoku Period (Japan's Warring States period) began, the family relocated to Echigo Province, strengthening their involvement in local politics in Echigo through such means as arranging to have Ryumatsu HACHIJO adopted by Fusayoshi UESUGI; in the process, however, they came into conflict with Echigo's Shugodai (deputy governor) family, the Nagao clan.
戦国時代(日本)になると越後国に下り、八条龍松を上杉房能の養子とするなどして越後への政治的介入を強めたが、その過程で越後守護代長尾氏と対立するようになる。