Toyotomi was completely defeated by the Tokugawa force at the Siege of Osaka in 1614 and in 1615, and in the same year, she was considered to have committed suicide with Hideyori and Harunaga ONO when Osaka-jo Castle fell.
慶長19年（1614年）と慶長20年（1615年）の大坂の役で徳川勢に完敗し、大坂城落城に際して秀頼や大野治長らと共に自害したとされる。