After conquering Shikoku, the Hosokawa clan fought in the Battle of Minato-gawa River and other battles, while Yoriharu himself fought in the Battle of Uchino in Kyoto and joined the attack on Yoshisada NITTA, who supported the Southern Court group and escaped to the Hokuriku region along with Takatsune SHIBA after the establishment of two separate imperial courts represented by different emperors (the Southern and Northern Courts).
細川氏は四国を平定して湊川の戦いなどで戦い、頼春は京都内野での戦いや、南北朝成立後には斯波高経らに従い北陸落ちした南朝の新田義貞攻めなどに従軍する。