He was assigned to the high positions of Naidaijin, Udaijin (Minister of the Right), Sadaijin (Minister of the Left), and when his older brother, Motozane, died early and his son, Motomichi KONOE, was still young, Motofusa became the sessho for Emperor Rokujo.
その後も内大臣、右大臣、左大臣などの高官を歴任し、兄の基実が早世すると、その息子である近衛基通が幼少のため、六条天皇の摂政に就任した。