In 645, Prince Naka no Oe (later, Emperor Tenji) and Kamako NAKATOMI (later, Kamatari FUJIWARA) assassinated Iruka SOGA at the Imperial Court, drove Emishi SOGA to suicide and annihilated the Soga clan, in what is known as the The Isshi Incident, or Incident of 645.
645年（皇極4年）の乙巳の変で、天智天皇・中臣鎌子（藤原鎌足）らが宮中（板蓋宮）で蘇我入鹿を暗殺し、蘇我蝦夷を自殺に追いやり、半世紀も続いた蘇我氏の体制を滅ぼした。