In Osaka no Eki (the Siege of Osaka), which started in 1614, Nobushige was against the siege and insisted on fighting aggressively at Seta in Uji (Otsu City) (around Seta Bridge, which spanned the Uji-gawa River) at first (some say it was the strategy of his father Nobuyuki who was a knowledgeable warrior).
慶長19年（1614年）に始まる大坂の役で信繁は、当初籠城に反対し、京を抑え、宇治・瀬田(大津市)（宇治川の瀬田橋付近）で積極的に迎え撃つよう主張した（知将である父・昌幸の策とも言われる）。