When the Incident at Honno-ji Temple ('Honnoji no hen' in Japanese) occurred, the Saito clan took advantage of the opportunity and changed sides and supported the Uesugi, thereby being ruined by Narimasa SASSA later.
しかし本能寺の変を機に斎藤一族は上杉方に寝返り、後に佐々成政によって没落させられた。