In 1563, when Takamoto suddenly died and Terumoto MORI, who was his nephew, took over as head of the family, Takakage and Motoharu supported young Terumoto.
永禄6年（1563年）隆元が急死し、甥毛利輝元が家督を継ぐと、元春と共に幼少の輝元を補佐した。