Following the death of Empress Komyo, two directors were installed; after the transfer of the national capital to the city of Heian-kyo, the Seyaku-in was also moved to the neighborhood of Gojo-Muromachi in order to continue the work; consequently, a private medicinal plant garden was established in Otokuni-gun, Yamashiro Province.
光明皇后崩御の後は知院事2名が置かれ、平安京へ遷都後も、施薬院は五条室町近くに移されて続行し、山城国乙訓郡に施薬院用の薬園が設けられた。