In 1493, the tenth Ashikaga Shogun, Yoshitane, was deposed by Masamoto HOSOKAWA and allies and replaced by the eleventh Ashikaga Shogun, Yoshizumi, while Masamoto himself assumed de facto leadership of the shogunate.
1493年(明応3)には細川政元らにより10代将軍足利義稙を廃立する明応の政変で11代将軍足利義澄を擁立し、自身が幕政を主導する。