Crown Prince Takahito already had a prince consort, Miyasundokoro FUJIWARA no Moshi (an adopted daughter of FUJIWARA no Yoshinobu), who entered the court through Soibushi (the acquisition ceremony of a feminine bed partner) and had given birth to their first child shortly before the Imperial Princess Keishi's entry into the court, and in succeeding years, one male and four female children were born between Crown Prince Takahito and Moshi.
また尊仁親王には添伏として入内した御息所藤原茂子（藤原能信養女）がおり、馨子内親王の入内は茂子が第一子を出産後間もなくであったのだが、その後も尊仁親王と茂子の間には合計一男四女が生まれた。