Under these conditions, Sadataka ISE, who had held power over the shogunate with Nagayoshi (Chokei), lost his position as regent of the old Mandokoro and rose in revolt only to be defeated by Nagayoshi (Chokei).
こうした中、永禄5年（1562年）には、長慶と手を結び幕政を壟断していた旧政所執事の伊勢貞孝が失脚し、反乱を起こすも長慶の手で討たれた。