In November 1578, Murashige ARAKI, who had taken a key role in attacking Ishiyama Hongan-ji Temple in Settsu, rebelled against Nobunaga (the Battle of Arioka-jo Castle) and Nobunaga's strategy against Hongan-ji Temple began to fell out of order seriously.
天正6年10月、摂津における石山本願寺討伐の要であった荒木村重の離反によって（有岡城の戦い）信長の対石山本願寺戦略に重大な狂いを見せた。