The political strife of succession to the 13th shogun Iesada TOKUGAWA of the Edo bakufu in the Ansei era was very famous, and the 'problem of heir of Shogun' usually refers to this strife.
特に江戸幕府13代将軍徳川家定の後継を巡って生じた安政年間の件が著名で単に「将軍継嗣問題」と呼んだ場合、この件を指すことも多い。