In 1518, Tsunehisa ordered his younger brother, Hisayuki, to attack Munekatsu NANJO of Hoki Province, while sending his eldest son, Masahisa AMAGO, to Togishi Castle where Soteki SAKURAI, who defected from the Amago clan, locked himself.
永正15年（1518年）、経久は弟の久幸に伯耆国の南条宗勝を攻めさせる一方、嫡男・尼子政久を叛旗を翻した桜井宗的の籠もる磨石城へ差し向けた。