Italy was the birthplace and heart of the Renaissance during the 1400s and 1500s. The Italian Renaissance marked the transition from the medieval period to the modern age as Europe recovered, economically and culturally, from the crises of the Late Middle Ages and entered the Early Modern Period. The Italian polities were now regional states effectively ruled by Princes, ''de facto'' monarchs in control of trade and administration, and their courts became major centres of the Arts and Sciences. The Italian princedoms represented a first form of modern states as opposed to feudal monarchies and multinational empires. The princedoms were led by political dynasties and merchant families such as the Medici in Florence, the Visconti and Sforza in the Duchy of Milan, the Doria in the Republic of Genoa, the Loredan, Mocenigo and Barbarigo in the Republic of Venice, the Este in Ferrara, and the Gonzaga in Mantua. The Renaissance was therefore a result of the wealth accumulated by Italian merchant cities combined with the patronage of its dominant families. Italian Renaissance exercised a dominant influence on subsequent European painting and sculpture for centuries afterwards, with artists such as Leonardo da Vinci, Brunelleschi, Botticelli, Michelangelo, Raphael, Giotto, Donatello, and Titian, and architects such as Filippo Brunelleschi, Leon Battista Alberti, Andrea Palladio, and Donato Bramante.