Callinicum early became the seat of a Christian diocese. In 388, Byzantine Emperor Theodosius the Great was informed that a crowd of Christians, led by their bishop, had destroyed the synagogue. He ordered the synagogue rebuilt at the expense of the bishop. Ambrose wrote to Theodosius, pointing out he was thereby "exposing the bishop to the danger of either acting against the truth or of death", and Theodosius rescinded his decree.