Although early Santiago appeared to be in imminent danger of permanent destruction, threatened by Indigenous attacks, earthquakes, and a series of floods, the city began to grow rapidly. Of the 126 blocks designed by Gamboa in 1558, 40 were occupied, and in 1580, the first major buildings in the city began to rise, the start of construction highlighted with the placing of the foundation stone of the first Cathedral in 1561 and the building of the church of San Francisco in 1572. Both of these constructions consisted of mainly adobe and stone. In addition to construction of important buildings, the city began to develop as nearby lands welcomed tens of thousands of livestock.