Despite its modest budget and numerous setbacks, academics and the sciences in Argentina have enjoyed an international respect since the turn of the 1900s, when Luis Agote devised the first safe and effective means of blood transfusion as well as René Favaloro, who was a pioneer in the improvement of the coronary artery bypass surgery. Argentine scientists are still on the cutting edge in fields such as nanotechnology, physics, computer sciences, molecular biology, oncology, ecology and cardiology. Juan Maldacena, an Argentine-American scientist, is a leading figure in string theory.