Argentines have received three Nobel Prizes in the Sciences. Bernardo Houssay, the first Latin American recipient, discovered the role of pituitary hormones in regulating glucose in animals, and shared the Nobel Prize in Physiology or Medicine in 1947. Luis Leloir discovered how organisms store energy converting glucose into glycogen and the compounds which are fundamental in metabolizing carbohydrates, receiving the Nobel Prize in Chemistry in 1970. César Milstein did extensive research in antibodies, sharing the Nobel Prize in Physiology or Medicine in 1984. Argentine research has led to treatments for heart diseases and several forms of cancer. Domingo Liotta designed and developed the first artificial heart that was successfully implanted in a human being in 1969. René Favaloro developed the techniques and performed the world's first coronary bypass surgery.