In the 16th century, during the Spanish colonization, indigenous peoples such as many of the Mariches, themselves descendants of the Kalina, converted to Roman Catholicism. Some of the resisting tribes or leaders are commemorated in place names, including Caracas, Chacao and Los Teques. The early colonial settlements focused on the northern coast, but in the mid-18th century, the Spanish pushed farther inland along the Orinoco River. Here, the Ye'kuana (then known as the Makiritare) organized serious resistance in 1775 and 1776.