Following the fall of Constantinople, the wars in Lombardy came to an end and a defensive alliance known as Italic League was formed between Venice, Naples, Florence, Milan, and the Papacy. Lorenzo ''the Magnificent'' de Medici was the greatest Florentine patron of the Renaissance and supporter of the Italic League. He notably avoided the collapse of the League in the aftermath of the Pazzi Conspiracy and during the aborted invasion of Italy by the Turks. However, the military campaign of Charles VIII of France in Italy caused the end of the Italic League and initiated the Italian Wars between the Valois and the Habsburgs. During the High Renaissance of the 1500s, Italy was therefore both the main European battleground and the cultural-economic centre of the continent. Popes such as Julius II (1503–1513) fought for the control of Italy against foreign monarchs, others such as Paul III (1534–1549) preferred to mediate between the European powers in order to secure peace in Italy. In the middle of this conflict, the Medici popes Leo X (1513–1521) and Clement VII (1523–1534) opposed the Protestant reformation and advanced the interests of their family. The end of the wars ultimately left northern Italy indirectly subject to the Austrian Habsburgs and Southern Italy under direct Spanish Habsburg rule.