During the first century BCE, the Parthian Empire subjugated the region but lost it to their Indo-Parthian vassals. In the mid-to-late first century CE the vast Kushan Empire, centered in Afghanistan, became great patrons of Buddhist culture, making Buddhism flourish throughout the region. The Kushans were overthrown by the Sassanids in the 3rd century CE, though the Indo-Sassanids continued to rule at least parts of the region. They were followed by the Kidarites who, in turn, was replaced by the Hephthalites. They were replaced by the Turk Shahi in the 7th century. The Buddhist Turk Shahi of Kabul was replaced by a Hindu dynasty before the Saffarids conquered the area in 870, this Hindu dynasty was called Hindu Shahi. Much of the northeastern and southern areas of the country remained dominated by Buddhist culture.