Damascus was conquered by Alexander the Great. After the death of Alexander in 323 BC, Damascus became the site of a struggle between the Seleucid and Ptolemaic empires. The control of the city passed frequently from one empire to the other. Seleucus I Nicator, one of Alexander's generals, made Antioch the capital of his vast empire, which led to the decline of Damascus' importance compared with new Seleucid cities such as Latakia in the north. Later, Demetrius III Philopator rebuilt the city according to the Greek hippodamian system and renamed it "Demetrias".