By 1826, the town was called ''Dushanbe Qurghan'' (, ''Dushanbe Qurghon'', with the suffix ''qurƣon'' from Turkic ''qurğan'', meaning "fortress"). It was first Russified as ''Dyushambe'' () in 1875. It had a caravanserai, a stopping point for travelers to Samarkand, Khujand, Kulob and the Pamirs. It boasted 14 mosques with maktabs, 2 madrassas, and 14 teahouses at the turn of the 19th century. At that time, the town was a citadel on a steep bank on the left bank of the Varzob River with 10,000 residents. It was a center for weaving, tanning, and iron smelting production in the region. Various states, including Hisor, exercised control over the city during the 18th and early 19th century despite Bukharan claims of sovereignty. In 1868, the Tsarist government established suzerainty over Bukhara. In the unstable environment of Russian intervention and local revolts, Bukhara took over the Dushanbe region, control over which the Emirate was able to sustain through the gradual establishment of a Russian-influenced centralized state. The first hospital in the village was constructed in 1915 by Russian investment and an early railroad was proposed to connect the market town with the Russian railway system in 1909, but was abandoned after a review determined the venture would not be profitable, although the town did have a functioning railroad to Kagan.