Life science is a key sector with extensive research and development activities. Danish engineers are world-leading in providing diabetes care equipment and medication products from Novo Nordisk and, since 2000, the Danish biotech company Novozymes, the world market leader in enzymes for first generation starch-based bioethanol, has pioneered development of enzymes for converting waste to cellulosic ethanol. ''Medicon Valley'', spanning the Øresund Region between Zealand and Sweden, is one of Europe's largest life science clusters, containing a large number of life science companies and research institutions located within a very small geographical area.