West Ham are close to agreeing a £10m deal to sell Pedro Obiang to Fiorentina, according to Sky in Italy.
The 26-year-old, who joined West Ham from Sampdoria in 2015, has made 17 appearances for Manuel Pellegrini's side this season.
He was on the bench for Saturday's 1-0 win over Arsenal as Declan Rice, who scored the winning goal, and captain Mark Noble started in midfield with new signing Samir Nasri playing ahead of them.
It is understood West Ham would not be willing to part with Obiang without securing a replacement. They are interested in signing versatile Chile international Gary Medel from Besiktas.
Jack Wilshere, who has made just five appearances since signing leaving Arsenal to join West Ham last summer, missed the win over his former side as he remains out with an ankle injury.
Colombia international Carlos Sanchez is out for the season after injuring his knee in the Carabao Cup against Macclesfield in September.