For one thing, men tend to have short finger nails, don't wear high heels or skirts, and things like seat belts can be uncomfortable if the cut across the chest - women have breasts and men do not. Women also tend to be smaller, and have smaller hands. So there are practical differences.

But obviously men and women have different tastes and preferences, much like they have different tastes in clothing, books and movies. So certainly marketing if different.

Age is another factor here too - cars for seniors are different from ones with young children, but that is a different article