I'm over 45 (by quite a bit) and don't ride to work as a rule, but I'm a fairly enthusiastic weekend warrior. Most of the folks in our Saturday group are men (and women) in that age group. Only two of us has been to a hospital with a cycling-related injury during the 10 years or so I've ridden with them. (One broken collar bone, dude tumbled right in front of me; the other with a broken hip when broadsided by a car on his commute.)

Hand signals, being more visible by getting in the lane if needed, and a red blinky rear light are my advice.