And the first commandment? 

"Thou shalt love the Lord thy God with all thy heart, and with all thy soul, and with all thy mind. This is the first and great commandment."

We give our hearts, souls and minds to God by understanding His will, accepting it and living accordingly.

"And the second is like unto it, Thou shalt love thy neighbour as thyself."
 
It is not loving ourselves or our neighbours to contradict God's created order - i.e male and female who physically, spiritually and mentally complement one another. 

"On these two commandments hang all the law and the prophets." 

Whilst the two commandments go together, God comes first and not man's desires or wants.