They are not "constructs" of men. They are understandings of God's will   for us through the use of reason and also His revelation. As Jesus said, “If I had not come and spoken unto them, they had not had sin: but now they have no excuse for their sin” (John 15:22). He also said, “I am not come to call the righteous but sinners to repentance” (Luke 5:31-32).

"Whoever commits sin transgresses also the law: for sin is the transgression of the law." (1 John 3:4)

"When you follow the desires of your sinful nature, the results are very clear: sexual immorality, impurity, lustful pleasures, idolatry, sorcery, hostility, quarreling, jealousy, outbursts of anger, selfish ambition, dissension, division,  envy, drunkenness, wild parties, and other sins like these. Let me tell you again, as I have before, that anyone living that sort of life will not inherit the Kingdom of God." (Galatians 5:19-21)