It was for her (Dr. Crusher). But Star Trek: Deep Space Nine featured another Trill (the "parasite") who has lived in both male and female bodies - though Dax was always heterosexual (I think), it offered some interesting opportunities for the female Dax (Jadzia) in most of the episodes. It was interesting and a great plot device.

I also look forward to the next incarnation of the Doctor - Missy was great. I've liked the past Doctors as well, but I personally think this will be fun. And I find Caldara's writing on this topic vacuous. What he takes as PC nonsense is just lived experience for millions (billions?) of people.