What is the theological misconception? What is the scientific reality? We know that people are born with disabilities both physical and mental, that is the reality. The reality also is that someone with an perfectly normal male body is of the male sex and not female. The same goes for a woman with a perfectly normal female body is of the female sex and not male.
A middle-aged married man with children who suddenly decides he is in the wrong body obviously has a mental problem.  To humour him and encourage him to pretend that he is a woman is cruel. Medical science can give him the cosmetic appearance of a woman up to a point but cannot alter his DNA. There is no misconception of any sort here.
I am not here referring to those whose sex at birth cannot be determined physically. That is an entirely different issue.