Trying to eliminate the religious wars supposedly based on Machiavelli only gets you back to 1512.  But then, 300 years of religious wars eliminated is better than nothing.  

You can eliminate:

The War of the League of Cambrai, sometimes known as the War of the Holy League  
and the Spanish conquest of the Aztec Empire.

and the Spanish conquest of Yucatán

and The First War of Kappel (Erster Kappelerkrieg) was an armed conflict in 1529 between the Protestant and the Catholic cantons of the Old Swiss Confederacy during the Reformation in Switzerland

and The Second War of Kappel (Zweiter Kappelerkrieg) was an armed conflict in 1531 between the Protestant and the Roman Catholic cantons of the Old Swiss Confederacy during the Reformation in Switzerland.

and The Prayer Book Rebellion of 1549 

and