I know of a couple of parishes where the sanctuary is alarmed.  Sometimes the Blessed Sacarament is placed on the altar (in the sanctuary) in a monstrance for adoration--from the nave.  Likewise, at least in a Catholic church, Stations of the Cross are hung in the nave, not the sanctuary.

During the Mass the demarcation between nave and sanctuary symbolically separates the heavenly and earthly action.  (Which is one of the reasons receiving our Lord at the rail instead of at the head of a queue is such a beautiful thing.)  It remains set aside for this purpose and few others even when Mass is not offered.  Typically when vespers or other hours are prayed they are only led from the sanctuary if led by a vested priest or deacon, and even then not always.  

Why open up the sanctuary for devotions that have for centuries taken place in the nave?  And where in the sanctuary do you intend for people to pray the rosary or stations?