Gender is base on the physical features  of the reproductive organ not how you feel.  Transgender, well i believe they fall in male or female up until final physical changes have been made. So for example,  Bruce Jenner, would still be male by description if  the physical feature remained.   I would be more concern with reason why it has become a concern these days....we need to make sure our environment is not contaminated to a point that we have challenges with our physical form.