{"action":"created","issue":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/issues/227","repository_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R","labels_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/issues/227/labels{/name}","comments_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/issues/227/comments","events_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/issues/227/events","html_url":"https://github.com/Open-Systems-Pharmacology/OSPSuite-R/pull/227","id":530102219,"node_id":"MDExOlB1bGxSZXF1ZXN0MzQ2ODU0MDM3","number":227,"title":"WIP #220 sensitivity calculation","user":{"login":"msevestre","id":1041237,"node_id":"MDQ6VXNlcjEwNDEyMzc=","avatar_url":"https://avatars2.githubusercontent.com/u/1041237?v=4","gravatar_id":"","url":"https://api.github.com/users/msevestre","html_url":"https://github.com/msevestre","followers_url":"https://api.github.com/users/msevestre/followers","following_url":"https://api.github.com/users/msevestre/following{/other_user}","gists_url":"https://api.github.com/users/msevestre/gists{/gist_id}","starred_url":"https://api.github.com/users/msevestre/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/msevestre/subscriptions","organizations_url":"https://api.github.com/users/msevestre/orgs","repos_url":"https://api.github.com/users/msevestre/repos","events_url":"https://api.github.com/users/msevestre/events{/privacy}","received_events_url":"https://api.github.com/users/msevestre/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":2,"created_at":"2019-11-28T23:50:39Z","updated_at":"2019-11-28T23:57:09Z","closed_at":null,"author_association":"MEMBER","pull_request":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/pulls/227","html_url":"https://github.com/Open-Systems-Pharmacology/OSPSuite-R/pull/227","diff_url":"https://github.com/Open-Systems-Pharmacology/OSPSuite-R/pull/227.diff","patch_url":"https://github.com/Open-Systems-Pharmacology/OSPSuite-R/pull/227.patch"},"body":""},"comment":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/issues/comments/559621127","html_url":"https://github.com/Open-Systems-Pharmacology/OSPSuite-R/pull/227#issuecomment-559621127","issue_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite-R/issues/227","id":559621127,"node_id":"MDEyOklzc3VlQ29tbWVudDU1OTYyMTEyNw==","user":{"login":"msevestre","id":1041237,"node_id":"MDQ6VXNlcjEwNDEyMzc=","avatar_url":"https://avatars2.githubusercontent.com/u/1041237?v=4","gravatar_id":"","url":"https://api.github.com/users/msevestre","html_url":"https://github.com/msevestre","followers_url":"https://api.github.com/users/msevestre/followers","following_url":"https://api.github.com/users/msevestre/following{/other_user}","gists_url":"https://api.github.com/users/msevestre/gists{/gist_id}","starred_url":"https://api.github.com/users/msevestre/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/msevestre/subscriptions","organizations_url":"https://api.github.com/users/msevestre/orgs","repos_url":"https://api.github.com/users/msevestre/repos","events_url":"https://api.github.com/users/msevestre/events{/privacy}","received_events_url":"https://api.github.com/users/msevestre/received_events","type":"User","site_admin":false},"created_at":"2019-11-28T23:57:08Z","updated_at":"2019-11-28T23:57:08Z","author_association":"MEMBER","body":"Example of output\r\n```\r\nPKParameterSensitivity: \r\n  Parameter path: Applications-IV-Application_1-ProtocolSchemaItem-DosePerBodyWeight\r\n  pK-Parameter: AUC\r\n  Output path: Organism|PeripheralVenousBlood|Caffeine|Plasma (Peripheral Venous Blood)\r\n  Value: 0.9999982\r\nPKParameterSensitivity: \r\n  Parameter path: Organism-Plasma protein scale factor\r\n  pK-Parameter: AUC\r\n  Output path: Organism|PeripheralVenousBlood|Caffeine|Plasma (Peripheral Venous Blood)\r\n  Value: -0.8416749\r\nPKParameterSensitivity: \r\n  Parameter path: Caffeine-Fraction unbound (plasma, reference value)\r\n  pK-Parameter: AUC\r\n  Output path: Organism|PeripheralVenousBlood|Caffeine|Plasma (Peripheral Venous Blood)\r\n  Value: -0.8416749\r\nPKParameterSensitivity: \r\n  Parameter path: Organism-Skin-Peripheral blood flow fraction\r\n  pK-Parameter: AUC\r\n  Output path: Organism|PeripheralVenousBlood|Caffeine|Plasma (Peripheral Venous Blood)\r\n  Value: 0.7150603\r\nPKParameterSensitivity: \r\n  Parameter path: Organism-Muscle-Vf (water)\r\n  pK-Parameter: AUC\r\n  Output path: Organism|PeripheralVenousBlood|Caffeine|Plasma (Peripheral Venous Blood)\r\n  Value: -0.3286448\r\nPKParameterSensitivity: \r\n  Parameter path: Organism-Muscle-Peripheral blood flow fraction\r\n  pK-Parameter: AUC\r\n  Output path: Organism|PeripheralVenousBlood|Caffeine|Plasma (Peripheral Venous Blood)\r\n  Value: 0.2849398\r\n```"}}
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