{"action":"created","issue":{"url":"https://api.github.com/repos/sg-s/xolotl/issues/302","repository_url":"https://api.github.com/repos/sg-s/xolotl","labels_url":"https://api.github.com/repos/sg-s/xolotl/issues/302/labels{/name}","comments_url":"https://api.github.com/repos/sg-s/xolotl/issues/302/comments","events_url":"https://api.github.com/repos/sg-s/xolotl/issues/302/events","html_url":"https://github.com/sg-s/xolotl/issues/302","id":390957116,"node_id":"MDU6SXNzdWUzOTA5NTcxMTY=","number":302,"title":"x.(compName).add() syntax issue and Leak issue","user":{"login":"luadam4c","id":36715881,"node_id":"MDQ6VXNlcjM2NzE1ODgx","avatar_url":"https://avatars3.githubusercontent.com/u/36715881?v=4","gravatar_id":"","url":"https://api.github.com/users/luadam4c","html_url":"https://github.com/luadam4c","followers_url":"https://api.github.com/users/luadam4c/followers","following_url":"https://api.github.com/users/luadam4c/following{/other_user}","gists_url":"https://api.github.com/users/luadam4c/gists{/gist_id}","starred_url":"https://api.github.com/users/luadam4c/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/luadam4c/subscriptions","organizations_url":"https://api.github.com/users/luadam4c/orgs","repos_url":"https://api.github.com/users/luadam4c/repos","events_url":"https://api.github.com/users/luadam4c/events{/privacy}","received_events_url":"https://api.github.com/users/luadam4c/received_events","type":"User","site_admin":false},"labels":[{"id":1161522119,"node_id":"MDU6TGFiZWwxMTYxNTIyMTE5","url":"https://api.github.com/repos/sg-s/xolotl/labels/more-information-needed","name":"more-information-needed","color":"0052cc","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":25,"created_at":"2018-12-14T04:02:56Z","updated_at":"2018-12-17T17:56:39Z","closed_at":null,"author_association":"CONTRIBUTOR","body":"I realized that if I only clamp the soma and not the dendrites (i.e., leave the V_clamp setting for dendrites as NaN), the currents in the dendrites goes to **infinity**, which is not physiological. \r\n\r\nI know in large invertebrates axons two-electrode voltage clamp is often performed. That's probably why you set the voltage clamp option to work that way. However, in mammalian neurons one usually performs a whole cell patch clamp, which is a single electrode voltage clamp. Therefore, I don't think it is safe to assume that the voltage is constant throughout the cell. You basically need to inject enough current to account for the entire surface area of the cell.\r\n\r\nThat's how NEURON works too. You can place an IClamp or a VClamp at a particular position in a particular compartment."},"comment":{"url":"https://api.github.com/repos/sg-s/xolotl/issues/comments/447937635","html_url":"https://github.com/sg-s/xolotl/issues/302#issuecomment-447937635","issue_url":"https://api.github.com/repos/sg-s/xolotl/issues/302","id":447937635,"node_id":"MDEyOklzc3VlQ29tbWVudDQ0NzkzNzYzNQ==","user":{"login":"sg-s","id":6005346,"node_id":"MDQ6VXNlcjYwMDUzNDY=","avatar_url":"https://avatars3.githubusercontent.com/u/6005346?v=4","gravatar_id":"","url":"https://api.github.com/users/sg-s","html_url":"https://github.com/sg-s","followers_url":"https://api.github.com/users/sg-s/followers","following_url":"https://api.github.com/users/sg-s/following{/other_user}","gists_url":"https://api.github.com/users/sg-s/gists{/gist_id}","starred_url":"https://api.github.com/users/sg-s/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/sg-s/subscriptions","organizations_url":"https://api.github.com/users/sg-s/orgs","repos_url":"https://api.github.com/users/sg-s/repos","events_url":"https://api.github.com/users/sg-s/events{/privacy}","received_events_url":"https://api.github.com/users/sg-s/received_events","type":"User","site_admin":false},"created_at":"2018-12-17T17:56:39Z","updated_at":"2018-12-17T17:56:39Z","author_association":"OWNER","body":"just uploaded a new release.\r\n\r\nBTW since you're familiar with git, you should probably not use the toolbox since it is (by design) meant to be a slow, stable release channel. if you clone this repo, cpplab, and the mtools dep., everything should work \r\n\r\nsee: https://xolotl.readthedocs.io/en/master/how-to/install-configure/#install-using-git\r\n\r\n"}}
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