{"action":"created","issue":{"url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment/issues/9","repository_url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment","labels_url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment/issues/9/labels{/name}","comments_url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment/issues/9/comments","events_url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment/issues/9/events","html_url":"https://github.com/waldronlab/MultiAssayExperiment/issues/9","id":31185132,"node_id":"MDU6SXNzdWUzMTE4NTEzMg==","number":9,"title":"how to create target prediction databases","user":{"login":"lwaldron","id":639942,"node_id":"MDQ6VXNlcjYzOTk0Mg==","avatar_url":"https://avatars3.githubusercontent.com/u/639942?v=4","gravatar_id":"","url":"https://api.github.com/users/lwaldron","html_url":"https://github.com/lwaldron","followers_url":"https://api.github.com/users/lwaldron/followers","following_url":"https://api.github.com/users/lwaldron/following{/other_user}","gists_url":"https://api.github.com/users/lwaldron/gists{/gist_id}","starred_url":"https://api.github.com/users/lwaldron/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/lwaldron/subscriptions","organizations_url":"https://api.github.com/users/lwaldron/orgs","repos_url":"https://api.github.com/users/lwaldron/repos","events_url":"https://api.github.com/users/lwaldron/events{/privacy}","received_events_url":"https://api.github.com/users/lwaldron/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":2,"created_at":"2014-04-09T19:02:06Z","updated_at":"2019-01-02T16:33:43Z","closed_at":null,"author_association":"COLLABORATOR","body":"Angela will build databases of RNA binding proteins (RBP) and their targets, and microRNAs and their targets.  Here are my initial suggestions for the RBP binding database, would appreciate further feedback.\n\nHave start and stop locations for RBP binding sites, which are in 3' or 5' UTR.  A given RBP can target multiple UTRs, and a given UTR can be targeted by multiple RBPs (many-to-many).  Also note that one RBP may have predicted target ranges that overlap.  The full set of RBPs for which there is a positional prediction is ~200.  Store as follows, initially as a tab-delimited file:\n\ntarget range, genomic range of RBP, p-value, Q-value, likelihood score.\n\nThis will be huge without any kind of filter, so do a soft filter using Q < 0.2.  We will want the eventual database to be flexible in order to include multiple lines of evidence (e.g. predictions, experimentally validated targets...).\n"},"comment":{"url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment/issues/comments/450912345","html_url":"https://github.com/waldronlab/MultiAssayExperiment/issues/9#issuecomment-450912345","issue_url":"https://api.github.com/repos/waldronlab/MultiAssayExperiment/issues/9","id":450912345,"node_id":"MDEyOklzc3VlQ29tbWVudDQ1MDkxMjM0NQ==","user":{"login":"stale[bot]","id":26384082,"node_id":"MDM6Qm90MjYzODQwODI=","avatar_url":"https://avatars3.githubusercontent.com/in/1724?v=4","gravatar_id":"","url":"https://api.github.com/users/stale%5Bbot%5D","html_url":"https://github.com/apps/stale","followers_url":"https://api.github.com/users/stale%5Bbot%5D/followers","following_url":"https://api.github.com/users/stale%5Bbot%5D/following{/other_user}","gists_url":"https://api.github.com/users/stale%5Bbot%5D/gists{/gist_id}","starred_url":"https://api.github.com/users/stale%5Bbot%5D/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/stale%5Bbot%5D/subscriptions","organizations_url":"https://api.github.com/users/stale%5Bbot%5D/orgs","repos_url":"https://api.github.com/users/stale%5Bbot%5D/repos","events_url":"https://api.github.com/users/stale%5Bbot%5D/events{/privacy}","received_events_url":"https://api.github.com/users/stale%5Bbot%5D/received_events","type":"Bot","site_admin":false},"created_at":"2019-01-02T16:33:43Z","updated_at":"2019-01-02T16:33:43Z","author_association":"NONE","body":"This issue has been automatically marked as stale because it has not had any recent activity. It will be closed if no further activity occurs. Thank you for your contributions.\n"}}
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