{"action":"closed","issue":{"url":"https://api.github.com/repos/oborel/obo-relations/issues/228","repository_url":"https://api.github.com/repos/oborel/obo-relations","labels_url":"https://api.github.com/repos/oborel/obo-relations/issues/228/labels{/name}","comments_url":"https://api.github.com/repos/oborel/obo-relations/issues/228/comments","events_url":"https://api.github.com/repos/oborel/obo-relations/issues/228/events","html_url":"https://github.com/oborel/obo-relations/issues/228","id":313730168,"number":228,"title":"Definition of 'acts upstream of'","user":{"login":"vanaukenk","id":1730534,"avatar_url":"https://avatars2.githubusercontent.com/u/1730534?v=4","gravatar_id":"","url":"https://api.github.com/users/vanaukenk","html_url":"https://github.com/vanaukenk","followers_url":"https://api.github.com/users/vanaukenk/followers","following_url":"https://api.github.com/users/vanaukenk/following{/other_user}","gists_url":"https://api.github.com/users/vanaukenk/gists{/gist_id}","starred_url":"https://api.github.com/users/vanaukenk/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/vanaukenk/subscriptions","organizations_url":"https://api.github.com/users/vanaukenk/orgs","repos_url":"https://api.github.com/users/vanaukenk/repos","events_url":"https://api.github.com/users/vanaukenk/events{/privacy}","received_events_url":"https://api.github.com/users/vanaukenk/received_events","type":"User","site_admin":false},"labels":[],"state":"closed","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":2,"created_at":"2018-04-12T13:35:58Z","updated_at":"2018-05-11T20:38:30Z","closed_at":"2018-05-11T20:38:30Z","author_association":"NONE","body":"We are working on the gene product-to-GO term relations and have a question about the formal definition of 'acts upsteam of'.\r\n\r\nThe current definition, as seen on OLS, is:\r\nc involved in regulation of p if c enables f and f causally upstream of p\r\n\r\nhttps://www.ebi.ac.uk/ols/ontologies/ro/properties?iri=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FRO_0002263\r\n\r\nWe were not sure about the 'involved in regulation' part and we were wondering if this new definition would be suitable:\r\n\r\nc acts upstream of p1 if c enables some f that is involved in p2 and p2 occurs chronologically before p1, is not part of p1, and affects the execution of p1.  c is a material entity and f, p1, p2 are processes.\r\n\r\nThx.\r\n--Kimberly and Pascale"}}
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