{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/15424","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15424/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15424/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15424/events","html_url":"https://github.com/geneontology/go-ontology/issues/15424","id":305607582,"number":15424,"title":"angiotensin term definitions need improving","user":{"login":"RLovering","id":12080010,"avatar_url":"https://avatars3.githubusercontent.com/u/12080010?v=4","gravatar_id":"","url":"https://api.github.com/users/RLovering","html_url":"https://github.com/RLovering","followers_url":"https://api.github.com/users/RLovering/followers","following_url":"https://api.github.com/users/RLovering/following{/other_user}","gists_url":"https://api.github.com/users/RLovering/gists{/gist_id}","starred_url":"https://api.github.com/users/RLovering/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/RLovering/subscriptions","organizations_url":"https://api.github.com/users/RLovering/orgs","repos_url":"https://api.github.com/users/RLovering/repos","events_url":"https://api.github.com/users/RLovering/events{/privacy}","received_events_url":"https://api.github.com/users/RLovering/received_events","type":"User","site_admin":false},"labels":[{"id":240250842,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/Other%20term-related%20request","name":"Other 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from https://github.com/geneontology/go-ontology/issues/15410#issuecomment-373291191 \r\n\r\nGO:0002002 regulation of angiotensin levels in blood\r\nprevious Definition (GO:0002002 GONUTS page)\r\nThe process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin.\r\n\r\nrecently Definition revised to: \"The process that modulates the level of angiotensin in the blood by balancing the maturation angiotensinogen to angiotensin and the catabolism of mature angiotensin. Angiotensinogen is processed by the renin protease.\"\r\n\r\nPlease change this again, as there are many enzymes involved in this process ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214724/ figure 1 ), not just renin, to:\r\n\"The proteolytic cleavage of angiotensinogen leads to the production of a variety of angiotensin isoforms. The process that modulates the level of a variety of angiotensin isoforms in the blood by the proteolytic cleavage of angiotensinogen and angiotensin isoforms to create the active peptide hormone angiotensin isoforms; modulation is also achieved through the removal of these isoforms from the circulation.\"\r\n\r\nWere there any other term definitions that were modified to remove 'renin substrate'? It seems to me that there are still lots of definitions that need revisions to recognise that renin is not the only enzyme involved and 'renin substrate' in the term is not appropriate as renin may digest other proteins than angiotensinogen\r\n\r\nIf you can provide a list of the terms that are being kept and their definitions I can try to workout how to revise these, unless you are happy with the suggestion above and can use this as a 'template'?\r\n\r\nRuth\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/373436560","html_url":"https://github.com/geneontology/go-ontology/issues/15424#issuecomment-373436560","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15424","id":373436560,"user":{"login":"pgaudet","id":4782928,"avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"created_at":"2018-03-15T16:23:34Z","updated_at":"2018-03-15T16:23:34Z","author_association":"CONTRIBUTOR","body":"@RLovering \r\nSorry I just looked more closely - if you start the definition with \"The proteolytic cleavage of angiotensinogen leads to the production of a variety of angiotensin isoforms\" then how is that different from 'angiotensin maturation'? \r\n\r\nHow about: \"The process that modulates the level of a variety of angiotensin isoforms in the blood. This occurs by the proteolytic cleavage of angiotensinogen and angiotensin isoforms to create the active peptide hormone angiotensin isoforms, as well as through the removal of these isoforms from the circulation.\"\r\n\r\nThanks, Pascale\r\n"}}
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