{"action":"created","issue":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/195","repository_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum","labels_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/195/labels{/name}","comments_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/195/comments","events_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/195/events","html_url":"https://github.com/Open-Systems-Pharmacology/Forum/issues/195","id":333028495,"node_id":"MDU6SXNzdWUzMzMwMjg0OTU=","number":195,"title":"Incompleted absorbtion","user":{"login":"farzanehmaleki","id":35151285,"node_id":"MDQ6VXNlcjM1MTUxMjg1","avatar_url":"https://avatars1.githubusercontent.com/u/35151285?v=4","gravatar_id":"","url":"https://api.github.com/users/farzanehmaleki","html_url":"https://github.com/farzanehmaleki","followers_url":"https://api.github.com/users/farzanehmaleki/followers","following_url":"https://api.github.com/users/farzanehmaleki/following{/other_user}","gists_url":"https://api.github.com/users/farzanehmaleki/gists{/gist_id}","starred_url":"https://api.github.com/users/farzanehmaleki/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/farzanehmaleki/subscriptions","organizations_url":"https://api.github.com/users/farzanehmaleki/orgs","repos_url":"https://api.github.com/users/farzanehmaleki/repos","events_url":"https://api.github.com/users/farzanehmaleki/events{/privacy}","received_events_url":"https://api.github.com/users/farzanehmaleki/received_events","type":"User","site_admin":false},"labels":[{"id":557073134,"node_id":"MDU6TGFiZWw1NTcwNzMxMzQ=","url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/labels/help%20wanted","name":"help wanted","color":"128A0C","default":true},{"id":557073136,"node_id":"MDU6TGFiZWw1NTcwNzMxMzY=","url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/labels/question","name":"question","color":"cc317c","default":true}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":3,"created_at":"2018-06-17T01:57:27Z","updated_at":"2018-06-21T23:40:50Z","closed_at":null,"author_association":"NONE","body":"Hi,\r\nI am using PK-Sim built-in template for Rifampin. I get this error message for oral dose. Any thought?\r\nI have ABCB1 (Efflux) OATP1B1 (Influx) as transporters\r\n\r\n<img width=\"1019\" alt=\"rif2\" src=\"https://user-images.githubusercontent.com/35151285/41503999-d9cf9cb8-71af-11e8-849c-46b9e4d4c2a7.png\">\r\n\r\n\r\nThank you,\r\nFarzan\r\n"},"comment":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/comments/399276402","html_url":"https://github.com/Open-Systems-Pharmacology/Forum/issues/195#issuecomment-399276402","issue_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/195","id":399276402,"node_id":"MDEyOklzc3VlQ29tbWVudDM5OTI3NjQwMg==","user":{"login":"farzanehmaleki","id":35151285,"node_id":"MDQ6VXNlcjM1MTUxMjg1","avatar_url":"https://avatars1.githubusercontent.com/u/35151285?v=4","gravatar_id":"","url":"https://api.github.com/users/farzanehmaleki","html_url":"https://github.com/farzanehmaleki","followers_url":"https://api.github.com/users/farzanehmaleki/followers","following_url":"https://api.github.com/users/farzanehmaleki/following{/other_user}","gists_url":"https://api.github.com/users/farzanehmaleki/gists{/gist_id}","starred_url":"https://api.github.com/users/farzanehmaleki/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/farzanehmaleki/subscriptions","organizations_url":"https://api.github.com/users/farzanehmaleki/orgs","repos_url":"https://api.github.com/users/farzanehmaleki/repos","events_url":"https://api.github.com/users/farzanehmaleki/events{/privacy}","received_events_url":"https://api.github.com/users/farzanehmaleki/received_events","type":"User","site_admin":false},"created_at":"2018-06-21T23:40:50Z","updated_at":"2018-06-21T23:40:50Z","author_association":"NONE","body":"My model has two issues, fraction absorbed (Fa) and half life (HL). I got Fa~3 with modified PK-Sim template of Rifampin (same processes, different parameters). With the original template however, Fa~1.05 with the same warning mentioned above. Playing with the simulation time did not change the Fa. \r\nReducing the simulation time to 12 hours improves the HL from ~10 to 4-5 hours which is what has been reported in the literature. But I have 24 hours oral data of 600 mg and cannot reduce the simulation time. For that simulation the HL remains 10 hours. The prediction looks good even with such high HL.\r\n\r\n![image](https://user-images.githubusercontent.com/35151285/41750410-b572222c-7589-11e8-846f-a0e164a7023b.png)\r\n\r\n How can I take care of EHC?\r\n\r\nBest,\r\nFarzan"}}
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