{"action":"created","issue":{"url":"https://api.github.com/repos/DavisBrian/seqMeta/issues/41","repository_url":"https://api.github.com/repos/DavisBrian/seqMeta","labels_url":"https://api.github.com/repos/DavisBrian/seqMeta/issues/41/labels{/name}","comments_url":"https://api.github.com/repos/DavisBrian/seqMeta/issues/41/comments","events_url":"https://api.github.com/repos/DavisBrian/seqMeta/issues/41/events","html_url":"https://github.com/DavisBrian/seqMeta/issues/41","id":344449084,"node_id":"MDU6SXNzdWUzNDQ0NDkwODQ=","number":41,"title":"cmaf greater than 1?","user":{"login":"elise625","id":20329581,"node_id":"MDQ6VXNlcjIwMzI5NTgx","avatar_url":"https://avatars3.githubusercontent.com/u/20329581?v=4","gravatar_id":"","url":"https://api.github.com/users/elise625","html_url":"https://github.com/elise625","followers_url":"https://api.github.com/users/elise625/followers","following_url":"https://api.github.com/users/elise625/following{/other_user}","gists_url":"https://api.github.com/users/elise625/gists{/gist_id}","starred_url":"https://api.github.com/users/elise625/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/elise625/subscriptions","organizations_url":"https://api.github.com/users/elise625/orgs","repos_url":"https://api.github.com/users/elise625/repos","events_url":"https://api.github.com/users/elise625/events{/privacy}","received_events_url":"https://api.github.com/users/elise625/received_events","type":"User","site_admin":false},"labels":[],"state":"closed","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":1,"created_at":"2018-07-25T13:42:42Z","updated_at":"2018-08-08T17:28:51Z","closed_at":"2018-08-08T17:28:51Z","author_association":"NONE","body":"Hello,\r\n\r\nI'm performing meta analysis using skatMeta function for rare variants with maf < 0.05. \r\nI have 5 cohorts in my meta analysis and for a lot of genes, i'm getting cmaf greater than 1. \r\nI'm having trouble explaining this since these are all variants with maf < 0.05 in individual cohorts? I don't have many snps in the gene either so I can't explain cmaf being so big?\r\n\r\nalso is there internal filtering done? It seems like the number of snps inputted doesn't match the output in meta-analysis."},"comment":{"url":"https://api.github.com/repos/DavisBrian/seqMeta/issues/comments/411487446","html_url":"https://github.com/DavisBrian/seqMeta/issues/41#issuecomment-411487446","issue_url":"https://api.github.com/repos/DavisBrian/seqMeta/issues/41","id":411487446,"node_id":"MDEyOklzc3VlQ29tbWVudDQxMTQ4NzQ0Ng==","user":{"login":"DavisBrian","id":7526919,"node_id":"MDQ6VXNlcjc1MjY5MTk=","avatar_url":"https://avatars2.githubusercontent.com/u/7526919?v=4","gravatar_id":"","url":"https://api.github.com/users/DavisBrian","html_url":"https://github.com/DavisBrian","followers_url":"https://api.github.com/users/DavisBrian/followers","following_url":"https://api.github.com/users/DavisBrian/following{/other_user}","gists_url":"https://api.github.com/users/DavisBrian/gists{/gist_id}","starred_url":"https://api.github.com/users/DavisBrian/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/DavisBrian/subscriptions","organizations_url":"https://api.github.com/users/DavisBrian/orgs","repos_url":"https://api.github.com/users/DavisBrian/repos","events_url":"https://api.github.com/users/DavisBrian/events{/privacy}","received_events_url":"https://api.github.com/users/DavisBrian/received_events","type":"User","site_admin":false},"created_at":"2018-08-08T17:28:51Z","updated_at":"2018-08-08T17:28:51Z","author_association":"OWNER","body":"No reproducible example provided."}}
{"actor":{"display_login":"DavisBrian"}}