{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/16707","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16707/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16707/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16707/events","html_url":"https://github.com/geneontology/go-ontology/issues/16707","id":385353765,"node_id":"MDU6SXNzdWUzODUzNTM3NjU=","number":16707,"title":"ntr? ATPase coupled to complex remodeling?","user":{"login":"mah11","id":5196259,"node_id":"MDQ6VXNlcjUxOTYyNTk=","avatar_url":"https://avatars0.githubusercontent.com/u/5196259?v=4","gravatar_id":"","url":"https://api.github.com/users/mah11","html_url":"https://github.com/mah11","followers_url":"https://api.github.com/users/mah11/followers","following_url":"https://api.github.com/users/mah11/following{/other_user}","gists_url":"https://api.github.com/users/mah11/gists{/gist_id}","starred_url":"https://api.github.com/users/mah11/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mah11/subscriptions","organizations_url":"https://api.github.com/users/mah11/orgs","repos_url":"https://api.github.com/users/mah11/repos","events_url":"https://api.github.com/users/mah11/events{/privacy}","received_events_url":"https://api.github.com/users/mah11/received_events","type":"User","site_admin":false},"labels":[{"id":240257345,"node_id":"MDU6TGFiZWwyNDAyNTczNDU=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/PomBase","name":"PomBase","color":"bfd4f2","default":false},{"id":407375226,"node_id":"MDU6TGFiZWw0MDczNzUyMjY=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/community%20curation","name":"community curation","color":"c2e0c6","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2018-11-28T16:33:49Z","updated_at":"2018-11-28T16:45:56Z","closed_at":null,"author_association":"MEMBER","body":"We've had a request from a community curator working on PMID:27667686, and I could do with some advice about it. The suggestion as submitted is:\r\n\r\nname: ATPase activity, driving the remodeling of substrate\r\ndef: An \"ATPase activity, driving the remodeling of substrates\" is an ATPase that drives the remodeling of its substrates, such as unfolding, release, during the ATPase cycle.\r\n\r\nIt's intended for Mdn1, a AAA-ATPase involved in 60S ribosomal subunit assembly. Mdn1 seems to contribute to various proteins first associating with, and then dissociating from, the nascent 60S particle, but I think the data in the paper don't directly address whether Mdn1 affects protein folding. It also doesn't feel right to lump folding together with \"remodeling\" in the sense of which proteins are present in a huge RNP like the ribosome or its precursors.\r\n\r\nWe can, of course, simple annotate to the generic 'ATPase activity' term (GO:0016887), but it would be nice to be able to say something a bit more specific than just ATPase activity part_of ribosomal large subunit assembly - i.e. to capture how the ATPase contributes to assembly. Can anyone suggest a term, or additional extensions to use with GO:0016887? (Move this to the annotation tracker if it's more appropriate there.)"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/442517644","html_url":"https://github.com/geneontology/go-ontology/issues/16707#issuecomment-442517644","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16707","id":442517644,"node_id":"MDEyOklzc3VlQ29tbWVudDQ0MjUxNzY0NA==","user":{"login":"pgaudet","id":4782928,"node_id":"MDQ6VXNlcjQ3ODI5Mjg=","avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"created_at":"2018-11-28T16:45:56Z","updated_at":"2018-11-28T16:45:56Z","author_association":"CONTRIBUTOR","body":"This sounds like a protein folding chaperone activity - we do have a process (waiting patiently to be annotated ;)     GO:0061992     ATP-dependent chaperone mediated protein folding; would that work ? \r\n\r\nPascale\r\n"}}
{"actor":{"display_login":"pgaudet"}}