{"action":"closed","issue":{"url":"https://api.github.com/repos/statisticalbiotechnology/maracluster/issues/15","repository_url":"https://api.github.com/repos/statisticalbiotechnology/maracluster","labels_url":"https://api.github.com/repos/statisticalbiotechnology/maracluster/issues/15/labels{/name}","comments_url":"https://api.github.com/repos/statisticalbiotechnology/maracluster/issues/15/comments","events_url":"https://api.github.com/repos/statisticalbiotechnology/maracluster/issues/15/events","html_url":"https://github.com/statisticalbiotechnology/maracluster/issues/15","id":394729095,"node_id":"MDU6SXNzdWUzOTQ3MjkwOTU=","number":15,"title":"More aggressive clustering","user":{"login":"bittremieux","id":10773123,"node_id":"MDQ6VXNlcjEwNzczMTIz","avatar_url":"https://avatars3.githubusercontent.com/u/10773123?v=4","gravatar_id":"","url":"https://api.github.com/users/bittremieux","html_url":"https://github.com/bittremieux","followers_url":"https://api.github.com/users/bittremieux/followers","following_url":"https://api.github.com/users/bittremieux/following{/other_user}","gists_url":"https://api.github.com/users/bittremieux/gists{/gist_id}","starred_url":"https://api.github.com/users/bittremieux/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/bittremieux/subscriptions","organizations_url":"https://api.github.com/users/bittremieux/orgs","repos_url":"https://api.github.com/users/bittremieux/repos","events_url":"https://api.github.com/users/bittremieux/events{/privacy}","received_events_url":"https://api.github.com/users/bittremieux/received_events","type":"User","site_admin":false},"labels":[],"state":"closed","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":4,"created_at":"2018-12-28T22:12:51Z","updated_at":"2019-01-04T01:51:54Z","closed_at":"2019-01-04T01:51:54Z","author_association":"NONE","body":"I have some data generated with dynamic exclusion disabled, so a lot of spectra a very similar to each other.\r\n\r\nTo condense this data I tried running MaRaCluster. However, a lot of the different clusters still have extremely similar consensus spectra and seem to correspond to the same peptide. Yet, those spectra have not been merged into a single cluster.\r\n\r\nSee for example:\r\n![image](https://user-images.githubusercontent.com/10773123/50529507-43386c00-0aaa-11e9-83b9-b2a214e0f17e.png)\r\nEach node is a consensus spectrum, with the width of the edges corresponding to the dot product similarity.\r\nYou can see four cliques that should probably be represented by a single consensus spectrum, yet MaRaCluster hasn't merged these spectra.\r\n\r\nHow can I set MaRaCluster to be more aggressive and combine more spectra into clusters?"}}
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