{"action":"created","issue":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/157","repository_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum","labels_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/157/labels{/name}","comments_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/157/comments","events_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/157/events","html_url":"https://github.com/Open-Systems-Pharmacology/Forum/issues/157","id":310203795,"number":157,"title":"Non linear Protein Binding Function in PK-Sim/Mobi","user":{"login":"hardik1chandasana","id":37915169,"avatar_url":"https://avatars2.githubusercontent.com/u/37915169?v=4","gravatar_id":"","url":"https://api.github.com/users/hardik1chandasana","html_url":"https://github.com/hardik1chandasana","followers_url":"https://api.github.com/users/hardik1chandasana/followers","following_url":"https://api.github.com/users/hardik1chandasana/following{/other_user}","gists_url":"https://api.github.com/users/hardik1chandasana/gists{/gist_id}","starred_url":"https://api.github.com/users/hardik1chandasana/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/hardik1chandasana/subscriptions","organizations_url":"https://api.github.com/users/hardik1chandasana/orgs","repos_url":"https://api.github.com/users/hardik1chandasana/repos","events_url":"https://api.github.com/users/hardik1chandasana/events{/privacy}","received_events_url":"https://api.github.com/users/hardik1chandasana/received_events","type":"User","site_admin":false},"labels":[{"id":600643033,"url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/labels/answer","name":"answer","color":"0052cc","default":false},{"id":557073136,"url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/labels/question","name":"question","color":"cc317c","default":true}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":9,"created_at":"2018-03-31T02:01:16Z","updated_at":"2018-05-16T18:42:50Z","closed_at":null,"author_association":"NONE","body":"Hello Everyone,\r\n\r\nI am working on a compound which has nonlinear protein binding in human plasma at a therapeutic concentration.\r\n\r\nI would like to know how to add concentration-dependent protein binding (Saturation in plasma and tissue) in PK-Sim/Mobi.\r\n\r\nThanks\r\n"},"comment":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/comments/389624226","html_url":"https://github.com/Open-Systems-Pharmacology/Forum/issues/157#issuecomment-389624226","issue_url":"https://api.github.com/repos/Open-Systems-Pharmacology/Forum/issues/157","id":389624226,"user":{"login":"msevestre","id":1041237,"avatar_url":"https://avatars2.githubusercontent.com/u/1041237?v=4","gravatar_id":"","url":"https://api.github.com/users/msevestre","html_url":"https://github.com/msevestre","followers_url":"https://api.github.com/users/msevestre/followers","following_url":"https://api.github.com/users/msevestre/following{/other_user}","gists_url":"https://api.github.com/users/msevestre/gists{/gist_id}","starred_url":"https://api.github.com/users/msevestre/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/msevestre/subscriptions","organizations_url":"https://api.github.com/users/msevestre/orgs","repos_url":"https://api.github.com/users/msevestre/repos","events_url":"https://api.github.com/users/msevestre/events{/privacy}","received_events_url":"https://api.github.com/users/msevestre/received_events","type":"User","site_admin":false},"created_at":"2018-05-16T18:42:50Z","updated_at":"2018-05-16T18:42:50Z","author_association":"MEMBER","body":"@hardik1chandasana Please let us know if you have any more questions. Cheers"}}
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