{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/16238","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16238/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16238/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16238/events","html_url":"https://github.com/geneontology/go-ontology/issues/16238","id":350096821,"node_id":"MDU6SXNzdWUzNTAwOTY4MjE=","number":16238,"title":"refine  cell separation after cytokinesis and *during* cytokinesis are  different processes","user":{"login":"ValWood","id":7359272,"node_id":"MDQ6VXNlcjczNTkyNzI=","avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"pgaudet","id":4782928,"node_id":"MDQ6VXNlcjQ3ODI5Mjg=","avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"assignees":[{"login":"pgaudet","id":4782928,"node_id":"MDQ6VXNlcjQ3ODI5Mjg=","avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false}],"milestone":null,"comments":8,"created_at":"2018-08-13T16:13:55Z","updated_at":"2018-08-14T15:44:56Z","closed_at":null,"author_association":"NONE","body":"related tickets\r\nhttps://github.com/geneontology/go-ontology/issues/16237\r\nhttps://github.com/geneontology/go-ontology/issues/15939\r\n\r\nGO:0000920  cell separation after cytokinesis\r\nThe process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components.\r\nand has child terms related to cell wall degradation\r\nhttps://www.pombase.org/term/GO:0000920\r\n\r\nWas created for fungi\r\nwhere \"cell separation\" occurs after the completion of cytokinesis (the  cell wall is digested during this process,  but  in mutants where this does not occur there is no cell cytokinesis/cycle defect, cells can keep cycling but 'chain together' (like a string of sausages in pombe).\r\n\r\n\r\nWe did not define this well enough to exclude cell separation which occurs  *during* cytokinesis  (i.e abscission) in  for example mammalian cells,\r\n\r\n- [x] 1. Suggest refine def to\r\nThe process of physically separating progeny cells after cytokinesis; this ~may involve~ involves enzymatic digestion of septum or cell wall components.\r\n(I don't know why it says \"may\")\r\n\r\nTo illustrate how the process differs in fungi:\r\n![speration](https://user-images.githubusercontent.com/7359272/44043771-9417398a-9f1b-11e8-8ec6-34055bdbd620.jpg)\r\n\r\n\r\nYou can see that the plasma membrane exists (and two daughter cells are no longer conjoined), before separation.\r\n(cytokinesis is complete when two daughter cells are created, even if they are still 'stuck' together via  their cell wall)\r\n\r\n- [ ] Add taxon constraint \"only in fungi\"  (possibly plant, I remember discussing with Tanya?)\r\nor maybe add never ins?\r\n\r\n- [3] \r\n\r\nAdd a comment:\r\n\r\nThis term is not for use to describe cell separation via abscission. Abscission is a different process. It is part of cytokinesis and involves ingression of the midbody?  and repair of the disrupted plasma membrane.\r\nHere the dausghter cells are still conjined:\r\n![abscission](https://user-images.githubusercontent.com/7359272/44044020-3c1916c6-9f1c-11e8-9b22-aa710fd2bb3c.jpg)\r\n\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/412918626","html_url":"https://github.com/geneontology/go-ontology/issues/16238#issuecomment-412918626","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16238","id":412918626,"node_id":"MDEyOklzc3VlQ29tbWVudDQxMjkxODYyNg==","user":{"login":"tberardini","id":4998871,"node_id":"MDQ6VXNlcjQ5OTg4NzE=","avatar_url":"https://avatars2.githubusercontent.com/u/4998871?v=4","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"created_at":"2018-08-14T15:44:56Z","updated_at":"2018-08-14T15:44:56Z","author_association":"CONTRIBUTOR","body":"How about _septum digestion after cytokinesis_?     It does not look like this process occurs in plant cells."}}
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