{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/16152","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16152/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16152/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16152/events","html_url":"https://github.com/geneontology/go-ontology/issues/16152","id":345258309,"node_id":"MDU6SXNzdWUzNDUyNTgzMDk=","number":16152,"title":"Merge terms transcription factor activity, RNA polymerase II distal enhancer  (and proximal) sequence-specific binding and children ","user":{"login":"pgaudet","id":4782928,"node_id":"MDQ6VXNlcjQ3ODI5Mjg=","avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"labels":[{"id":240261629,"node_id":"MDU6TGFiZWwyNDAyNjE2Mjk=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/transcription","name":"transcription","color":"fbca04","default":false}],"state":"open","locked":false,"assignee":{"login":"pgaudet","id":4782928,"node_id":"MDQ6VXNlcjQ3ODI5Mjg=","avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"assignees":[{"login":"pgaudet","id":4782928,"node_id":"MDQ6VXNlcjQ3ODI5Mjg=","avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false}],"milestone":null,"comments":25,"created_at":"2018-07-27T14:56:54Z","updated_at":"2018-08-08T16:32:49Z","closed_at":null,"author_association":"CONTRIBUTOR","body":"The transcription working group has agreed that these terms are too specific under the transcription factor branch, and we propose to merge as indicated below: \r\n - [ ] GO:0003705  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | 161 manual annotations \r\n - [ ] GO:0000982  transcription factor activity, RNA polymerase II proximal promoter   sequence-specific DNA binding | 63 manual annotations \r\n**-> merge into GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific**\r\n\r\n----\r\n\r\n - [ ] GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer   sequence-specific DNA binding | 44 manual annotations \r\n - [ ] GO:0001077  transcriptional activator activity, RNA polymerase II proximal promoter   sequence-specific DNA binding | 651 manual annotations \r\n**-> merge into GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific**\r\n\r\n\r\n----\r\n - [ ] GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer   sequence-specific binding | 12 manual annotations \r\n - [ ] GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter   sequence-specific DNA binding | 275 manual annotations \r\n**-> merge into GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific**\r\n\r\n\r\n----\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/411469908","html_url":"https://github.com/geneontology/go-ontology/issues/16152#issuecomment-411469908","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16152","id":411469908,"node_id":"MDEyOklzc3VlQ29tbWVudDQxMTQ2OTkwOA==","user":{"login":"ValWood","id":7359272,"node_id":"MDQ6VXNlcjczNTkyNzI=","avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2018-08-08T16:32:49Z","updated_at":"2018-08-08T16:32:49Z","author_association":"NONE","body":"Ruth, I don't know what else  you mean by \r\n\r\n\"regulation of DNA binding TF activity\"\r\n\r\n\r\nDo you have a specific example of where you are regulating the \"trancription factor activty\" but  you are not regulating the binding?\r\n\r\n\r\nDNA-binding transcription factor activity (GO:0003700)\r\nA protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.\r\n\r\nThe first part of this def is the DNA binding activity. The second part is the process that is regulated by the binding.\r\n\r\nSo what can you be regulating apart from the DNA binding here?\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n"}}
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