{"action":"created","issue":{"url":"https://api.github.com/repos/ITHIM/ITHIM-R/issues/2","repository_url":"https://api.github.com/repos/ITHIM/ITHIM-R","labels_url":"https://api.github.com/repos/ITHIM/ITHIM-R/issues/2/labels{/name}","comments_url":"https://api.github.com/repos/ITHIM/ITHIM-R/issues/2/comments","events_url":"https://api.github.com/repos/ITHIM/ITHIM-R/issues/2/events","html_url":"https://github.com/ITHIM/ITHIM-R/issues/2","id":289643300,"number":2,"title":"Air pollution RRs (PM2.5)","user":{"login":"markotainio","id":25430495,"avatar_url":"https://avatars1.githubusercontent.com/u/25430495?v=4","gravatar_id":"","url":"https://api.github.com/users/markotainio","html_url":"https://github.com/markotainio","followers_url":"https://api.github.com/users/markotainio/followers","following_url":"https://api.github.com/users/markotainio/following{/other_user}","gists_url":"https://api.github.com/users/markotainio/gists{/gist_id}","starred_url":"https://api.github.com/users/markotainio/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/markotainio/subscriptions","organizations_url":"https://api.github.com/users/markotainio/orgs","repos_url":"https://api.github.com/users/markotainio/repos","events_url":"https://api.github.com/users/markotainio/events{/privacy}","received_events_url":"https://api.github.com/users/markotainio/received_events","type":"User","site_admin":false},"labels":[{"id":808828924,"url":"https://api.github.com/repos/ITHIM/ITHIM-R/labels/Air%20pollution","name":"Air pollution","color":"1aa5af","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":12,"created_at":"2018-01-18T14:15:20Z","updated_at":"2018-02-15T11:48:24Z","closed_at":null,"author_association":"CONTRIBUTOR","body":"This issue is about discussion how we transfer air pollution concentration for RRs. With air pollution we mean at this stage fine particulate matter (PM2.5).\r\n\r\n###\r\nThis divides to two parts:\r\n\r\n1. For disease specific RRs we use the method from IHME Global Burden of Disease study (so called Integrated Risk Functions, IRFs). The methodology has been presented in Burnett et al. 2014 article. http://dx.doi.org/10.1289/ehp.1307049.\r\n2. Diseases for adults are:\r\n- ischemic heart disease (IHD)\r\n- cerebrovascular disease (stroke)\r\n- chronic obstructive pulmonary\r\n- disease (COPD)\r\n- lung cancer (LC) \r\n\r\n3. Methodology to apply these values is in Cohen et al. 2017 paper. http://dx.doi.org/10.1016/\r\nS0140-6736(17)30505-6\r\n\r\n4. Key equation is in page 1910 in Cohen et al. However, that paper wont include parameters needed to do the calculations. This we need to ask from Rick Burnett directly.\r\n\r\n\r\n###\r\nFor all-cause mortality we will use similar method after the new study describing the method and results will be published. This should happen in 2018.\r\n\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/ITHIM/ITHIM-R/issues/comments/365904200","html_url":"https://github.com/ITHIM/ITHIM-R/issues/2#issuecomment-365904200","issue_url":"https://api.github.com/repos/ITHIM/ITHIM-R/issues/2","id":365904200,"user":{"login":"markotainio","id":25430495,"avatar_url":"https://avatars1.githubusercontent.com/u/25430495?v=4","gravatar_id":"","url":"https://api.github.com/users/markotainio","html_url":"https://github.com/markotainio","followers_url":"https://api.github.com/users/markotainio/followers","following_url":"https://api.github.com/users/markotainio/following{/other_user}","gists_url":"https://api.github.com/users/markotainio/gists{/gist_id}","starred_url":"https://api.github.com/users/markotainio/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/markotainio/subscriptions","organizations_url":"https://api.github.com/users/markotainio/orgs","repos_url":"https://api.github.com/users/markotainio/repos","events_url":"https://api.github.com/users/markotainio/events{/privacy}","received_events_url":"https://api.github.com/users/markotainio/received_events","type":"User","site_admin":false},"created_at":"2018-02-15T11:48:24Z","updated_at":"2018-02-15T11:48:24Z","author_association":"CONTRIBUTOR","body":"Typical form for log-linear DRF for PM2.5 has equation:\r\n\r\nRR = EXP(LN(RR)*(PM2.5concentration/PM2.5concentrationRR))\r\n\r\nFor example, based on Heroux et al. 2015 paper, which defines WHO recommended RR for all-cause mortality, the equations is:\r\n\r\nRR = EXP(LN(1.062)*(PM2.5concentration/10))\r\n\r\nSo here parameters needed are:\r\nRR = 1.062\r\nPM2.5 concentration for which the RR has been define = 10\r\nPossible threshold value under which RR is 1 = Here none.\r\n\r\nSo in fact we need 1-3 parameters, if we restrict the RRs for log-linear models (which is the most common way). @syounkin "}}
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