{"action":"created","issue":{"url":"https://api.github.com/repos/Ensembl/VEP_plugins/issues/103","repository_url":"https://api.github.com/repos/Ensembl/VEP_plugins","labels_url":"https://api.github.com/repos/Ensembl/VEP_plugins/issues/103/labels{/name}","comments_url":"https://api.github.com/repos/Ensembl/VEP_plugins/issues/103/comments","events_url":"https://api.github.com/repos/Ensembl/VEP_plugins/issues/103/events","html_url":"https://github.com/Ensembl/VEP_plugins/issues/103","id":363997478,"node_id":"MDU6SXNzdWUzNjM5OTc0Nzg=","number":103,"title":"MaxEntScan score interpretation","user":{"login":"thedam","id":634773,"node_id":"MDQ6VXNlcjYzNDc3Mw==","avatar_url":"https://avatars1.githubusercontent.com/u/634773?v=4","gravatar_id":"","url":"https://api.github.com/users/thedam","html_url":"https://github.com/thedam","followers_url":"https://api.github.com/users/thedam/followers","following_url":"https://api.github.com/users/thedam/following{/other_user}","gists_url":"https://api.github.com/users/thedam/gists{/gist_id}","starred_url":"https://api.github.com/users/thedam/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/thedam/subscriptions","organizations_url":"https://api.github.com/users/thedam/orgs","repos_url":"https://api.github.com/users/thedam/repos","events_url":"https://api.github.com/users/thedam/events{/privacy}","received_events_url":"https://api.github.com/users/thedam/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":1,"created_at":"2018-09-26T12:12:16Z","updated_at":"2018-09-26T12:54:28Z","closed_at":null,"author_association":"NONE","body":"What is the interpretation of MaxEntScan scores?\r\n\r\nfor wariant: `11_117863938_C_G` I get such numbers.\r\n```\r\nMaxEntScan_alt    3.8294583218888\r\nMaxEntScan_diff   1.02692945321821\r\nMaxEntScan_ref    4.85638777510701\r\n```\r\nI guess these numbers are for splicing acceptor, as we have ` NM_001558.3:c.368-18C>G`\r\nIs there any min/max value? I can't find any clear answer...\r\n\r\nThanks\r\nDamian"},"comment":{"url":"https://api.github.com/repos/Ensembl/VEP_plugins/issues/comments/424704220","html_url":"https://github.com/Ensembl/VEP_plugins/issues/103#issuecomment-424704220","issue_url":"https://api.github.com/repos/Ensembl/VEP_plugins/issues/103","id":424704220,"node_id":"MDEyOklzc3VlQ29tbWVudDQyNDcwNDIyMA==","user":{"login":"ima23","id":6177217,"node_id":"MDQ6VXNlcjYxNzcyMTc=","avatar_url":"https://avatars2.githubusercontent.com/u/6177217?v=4","gravatar_id":"","url":"https://api.github.com/users/ima23","html_url":"https://github.com/ima23","followers_url":"https://api.github.com/users/ima23/followers","following_url":"https://api.github.com/users/ima23/following{/other_user}","gists_url":"https://api.github.com/users/ima23/gists{/gist_id}","starred_url":"https://api.github.com/users/ima23/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ima23/subscriptions","organizations_url":"https://api.github.com/users/ima23/orgs","repos_url":"https://api.github.com/users/ima23/repos","events_url":"https://api.github.com/users/ima23/events{/privacy}","received_events_url":"https://api.github.com/users/ima23/received_events","type":"User","site_admin":false},"created_at":"2018-09-26T12:54:28Z","updated_at":"2018-09-26T12:54:28Z","author_association":"CONTRIBUTOR","body":"Hi Damian,\r\n\r\nThe scores represent the maximum entropy scores of the model the authors built to reflect the difference between the reference splice region and the splice region with the variation (see Eng et al. 2004: https://www.ncbi.nlm.nih.gov/pubmed/14695534). \r\nFor min/max values you could have a look at the info on their website: http://genes.mit.edu/burgelab/maxent/Xmaxentscan_scoreseq.html.\r\n\r\nBest wishes,\r\nIrina"}}
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