{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-annotation/issues/1930","repository_url":"https://api.github.com/repos/geneontology/go-annotation","labels_url":"https://api.github.com/repos/geneontology/go-annotation/issues/1930/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-annotation/issues/1930/comments","events_url":"https://api.github.com/repos/geneontology/go-annotation/issues/1930/events","html_url":"https://github.com/geneontology/go-annotation/issues/1930","id":314066066,"number":1930,"title":" IPR014752 signalling","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[{"id":243702118,"url":"https://api.github.com/repos/geneontology/go-annotation/labels/InterPro%20mapping","name":"InterPro mapping","color":"808ad6","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2018-04-13T11:10:45Z","updated_at":"2018-04-13T11:13:36Z","closed_at":null,"author_association":"NONE","body":"\r\nI'm not super-confident about this, but I'm not convinced that all \"arrestin\" family members have a role in \"signalling\".\r\nalthough wikepedia supports such a role\r\nhttps://en.wikipedia.org/wiki/Arrestin\r\nIt might not always be true.\r\n\r\nIf they are \"endocytic adaptors\". It follows that if they  may have a more general role in endocytosis, they are only involved in signalling when they are endocytosing \"receptors\" or other signalling pathway components...\r\n\r\nSo we would need to be sure about the target molecules to make this annotation?\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-annotation/issues/comments/381104140","html_url":"https://github.com/geneontology/go-annotation/issues/1930#issuecomment-381104140","issue_url":"https://api.github.com/repos/geneontology/go-annotation/issues/1930","id":381104140,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2018-04-13T11:13:36Z","updated_at":"2018-04-13T11:13:36Z","author_association":"NONE","body":"I found this member\r\nhttps://www.pombase.org/gene/SPAC4G9.13c\r\nvps26 is a retromer complex subunit involved in retrograde transport, endosome to Golgi\r\n\r\nso here \"signalling\" isn't right...\r\n\r\n"}}
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