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Problem description\r\n\r\n> Some biomass precursors are taken from the media and directly consumed by the biomass reaction. It might not be a problem for some ions or metabolites with known auxotrophy, but when there are too many of these metabolites, it points to artefacts of gap-filling. This mostly happens in case of automatically-generated models. Starting with a complicated automatically generated biomass formulation followed by gap-filling (which basically tries to minimise the added reactions), would lead to many biomass metabolites being \"direct mets\". It might be useful to report the ratio of biomass metabolites that are direct mets.\r\n\r\n- Parizad Babayi, comment on the manuscript."},"comment":{"url":"https://api.github.com/repos/opencobra/memote/issues/comments/362545901","html_url":"https://github.com/opencobra/memote/issues/257#issuecomment-362545901","issue_url":"https://api.github.com/repos/opencobra/memote/issues/257","id":362545901,"user":{"login":"Midnighter","id":135653,"avatar_url":"https://avatars1.githubusercontent.com/u/135653?v=4","gravatar_id":"","url":"https://api.github.com/users/Midnighter","html_url":"https://github.com/Midnighter","followers_url":"https://api.github.com/users/Midnighter/followers","following_url":"https://api.github.com/users/Midnighter/following{/other_user}","gists_url":"https://api.github.com/users/Midnighter/gists{/gist_id}","starred_url":"https://api.github.com/users/Midnighter/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/Midnighter/subscriptions","organizations_url":"https://api.github.com/users/Midnighter/orgs","repos_url":"https://api.github.com/users/Midnighter/repos","events_url":"https://api.github.com/users/Midnighter/events{/privacy}","received_events_url":"https://api.github.com/users/Midnighter/received_events","type":"User","site_admin":false},"created_at":"2018-02-02T10:18:05Z","updated_at":"2018-02-02T10:18:05Z","author_association":"MEMBER","body":"Flux direction in default medium conditions?"}}
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