{"action":"created","issue":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/issues/759","repository_url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim","labels_url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/issues/759/labels{/name}","comments_url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/issues/759/comments","events_url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/issues/759/events","html_url":"https://github.com/Open-Systems-Pharmacology/PK-Sim/issues/759","id":324123601,"number":759,"title":"Allow user defined variability for more parameters","user":{"login":"msevestre","id":1041237,"avatar_url":"https://avatars2.githubusercontent.com/u/1041237?v=4","gravatar_id":"","url":"https://api.github.com/users/msevestre","html_url":"https://github.com/msevestre","followers_url":"https://api.github.com/users/msevestre/followers","following_url":"https://api.github.com/users/msevestre/following{/other_user}","gists_url":"https://api.github.com/users/msevestre/gists{/gist_id}","starred_url":"https://api.github.com/users/msevestre/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/msevestre/subscriptions","organizations_url":"https://api.github.com/users/msevestre/orgs","repos_url":"https://api.github.com/users/msevestre/repos","events_url":"https://api.github.com/users/msevestre/events{/privacy}","received_events_url":"https://api.github.com/users/msevestre/received_events","type":"User","site_admin":false},"labels":[{"id":536706817,"url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/labels/type:%20feature","name":"type: feature","color":"fbca04","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":7,"created_at":"2018-05-17T17:50:49Z","updated_at":"2018-05-21T18:03:00Z","closed_at":null,"author_association":"MEMBER","body":"Dose would be  a great candidate.\r\nLet's list out all potential parameters for which `CanBeVariedInPopulation` should be set to `true`"},"comment":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/issues/comments/390734099","html_url":"https://github.com/Open-Systems-Pharmacology/PK-Sim/issues/759#issuecomment-390734099","issue_url":"https://api.github.com/repos/Open-Systems-Pharmacology/PK-Sim/issues/759","id":390734099,"user":{"login":"StephanSchaller","id":25477643,"avatar_url":"https://avatars3.githubusercontent.com/u/25477643?v=4","gravatar_id":"","url":"https://api.github.com/users/StephanSchaller","html_url":"https://github.com/StephanSchaller","followers_url":"https://api.github.com/users/StephanSchaller/followers","following_url":"https://api.github.com/users/StephanSchaller/following{/other_user}","gists_url":"https://api.github.com/users/StephanSchaller/gists{/gist_id}","starred_url":"https://api.github.com/users/StephanSchaller/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/StephanSchaller/subscriptions","organizations_url":"https://api.github.com/users/StephanSchaller/orgs","repos_url":"https://api.github.com/users/StephanSchaller/repos","events_url":"https://api.github.com/users/StephanSchaller/events{/privacy}","received_events_url":"https://api.github.com/users/StephanSchaller/received_events","type":"User","site_admin":false},"created_at":"2018-05-21T18:03:00Z","updated_at":"2018-05-21T18:03:00Z","author_association":"MEMBER","body":"> should we use Mean(Dosing_time_i) for calculations\r\n\r\nIt should be calculated relative to the intended dosing time. Variation of dosing time is to simulate delays in applying your dose as planned (few may be earlier, most are later). So it probably looks like a log-normal distribution with a large (> 1) sigma with the intended dosing time at its maximum (e^(µ-sigma^2)).\r\nThis may be a problem if intended dosing time is supposed to be t = 0 min as we will get quite a few \"Start Times\" < 0?\r\n\r\nIn any case variation of \"dosing time\" is a nice to have, but I believe if it's too much of an effort, that there are more important features (and anyone really interested can code sth. in R/MATLAB to simulate this)"}}
{"actor":{"display_login":"StephanSchaller"}}