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Simulation data generation: \n+Simulated single cell data was generated by splatter [@doi:10.1186/s13059-017-1305-0]. \n+\n+Parameters used:\n+* nCells - The number of cells to simulate: 500 - 5000\n+* nGenes - The number of genes to simulate: 20000 - 6000\n+* nGroups - The number of celltypes: 5 - 15\n+* outlier - probability of a gene that is an expression outlier:  0.1 - 0.5\n+* default parameter is ncells = 600, nGenes = 20000, celltypes = 5, batchsize = 1\n+\n+Simulation statistics under different parameters:\n+\n+![](images/mean.gene.exp.bmp)","path":"content/03.aim1.md","position":18,"original_position":18,"commit_id":"69dfce33208e6368623a1ba6d025723cf06d8f0f","original_commit_id":"69dfce33208e6368623a1ba6d025723cf06d8f0f","user":{"login":"huqiwen0313","id":8357654,"avatar_url":"https://avatars2.githubusercontent.com/u/8357654?v=4","gravatar_id":"","url":"https://api.github.com/users/huqiwen0313","html_url":"https://github.com/huqiwen0313","followers_url":"https://api.github.com/users/huqiwen0313/followers","following_url":"https://api.github.com/users/huqiwen0313/following{/other_user}","gists_url":"https://api.github.com/users/huqiwen0313/gists{/gist_id}","starred_url":"https://api.github.com/users/huqiwen0313/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/huqiwen0313/subscriptions","organizations_url":"https://api.github.com/users/huqiwen0313/orgs","repos_url":"https://api.github.com/users/huqiwen0313/repos","events_url":"https://api.github.com/users/huqiwen0313/events{/privacy}","received_events_url":"https://api.github.com/users/huqiwen0313/received_events","type":"User","site_admin":false},"body":"It is the mean expression of genes from different samples for different simulation parameters. I will describe it 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