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It may be fairly obvious, but I could see putting something like \"To convert all the GTCs in a directory, run with DIR/*.gtc\" in the README helping with use-ability a bit.","created_at":"2018-03-07T23:26:13Z","updated_at":"2018-03-07T23:26:13Z","html_url":"https://github.com/Illumina/GTCtoVCF/pull/9#discussion_r173018538","pull_request_url":"https://api.github.com/repos/Illumina/GTCtoVCF/pulls/9","author_association":"COLLABORATOR","_links":{"self":{"href":"https://api.github.com/repos/Illumina/GTCtoVCF/pulls/comments/173018538"},"html":{"href":"https://github.com/Illumina/GTCtoVCF/pull/9#discussion_r173018538"},"pull_request":{"href":"https://api.github.com/repos/Illumina/GTCtoVCF/pulls/9"}},"in_reply_to_id":172667709},"pull_request":{"url":"https://api.github.com/repos/Illumina/GTCtoVCF/pulls/9","id":173279301,"html_url":"https://github.com/Illumina/GTCtoVCF/pull/9","diff_url":"https://github.com/Illumina/GTCtoVCF/pull/9.diff","patch_url":"https://github.com/Illumina/GTCtoVCF/pull/9.patch","issue_url":"https://api.github.com/repos/Illumina/GTCtoVCF/issues/9","number":9,"state":"open","locked":false,"title":"Multi gtc","user":{"login":"KelleyRyanM","id":3483888,"avatar_url":"https://avatars0.githubusercontent.com/u/3483888?v=4","gravatar_id":"","url":"https://api.github.com/users/KelleyRyanM","html_url":"https://github.com/KelleyRyanM","followers_url":"https://api.github.com/users/KelleyRyanM/followers","following_url":"https://api.github.com/users/KelleyRyanM/following{/other_user}","gists_url":"https://api.github.com/users/KelleyRyanM/gists{/gist_id}","starred_url":"https://api.github.com/users/KelleyRyanM/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/KelleyRyanM/subscriptions","organizations_url":"https://api.github.com/users/KelleyRyanM/orgs","repos_url":"https://api.github.com/users/KelleyRyanM/repos","events_url":"https://api.github.com/users/KelleyRyanM/events{/privacy}","received_events_url":"https://api.github.com/users/KelleyRyanM/received_events","type":"User","site_admin":false},"body":"Allow specification of multiple input GTC files on command-line in order to improve analysis time by avoiding repeated loading and instantiation of manifest and other data.\r\n\r\nFor sample HumanCore dataset, performance is improved from ~50 minutes to ~10 minutes on 48 GTC input files. 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