{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/15693","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15693/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15693/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15693/events","html_url":"https://github.com/geneontology/go-ontology/issues/15693","id":320092299,"number":15693,"title":"query about Lem3p-Dnf1p complex","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[{"id":240607772,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/protein%20complex","name":"protein complex","color":"fbca04","default":false}],"state":"open","locked":false,"assignee":{"login":"hdrabkin","id":10440080,"avatar_url":"https://avatars0.githubusercontent.com/u/10440080?v=4","gravatar_id":"","url":"https://api.github.com/users/hdrabkin","html_url":"https://github.com/hdrabkin","followers_url":"https://api.github.com/users/hdrabkin/followers","following_url":"https://api.github.com/users/hdrabkin/following{/other_user}","gists_url":"https://api.github.com/users/hdrabkin/gists{/gist_id}","starred_url":"https://api.github.com/users/hdrabkin/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/hdrabkin/subscriptions","organizations_url":"https://api.github.com/users/hdrabkin/orgs","repos_url":"https://api.github.com/users/hdrabkin/repos","events_url":"https://api.github.com/users/hdrabkin/events{/privacy}","received_events_url":"https://api.github.com/users/hdrabkin/received_events","type":"User","site_admin":false},"assignees":[{"login":"hdrabkin","id":10440080,"avatar_url":"https://avatars0.githubusercontent.com/u/10440080?v=4","gravatar_id":"","url":"https://api.github.com/users/hdrabkin","html_url":"https://github.com/hdrabkin","followers_url":"https://api.github.com/users/hdrabkin/followers","following_url":"https://api.github.com/users/hdrabkin/following{/other_user}","gists_url":"https://api.github.com/users/hdrabkin/gists{/gist_id}","starred_url":"https://api.github.com/users/hdrabkin/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/hdrabkin/subscriptions","organizations_url":"https://api.github.com/users/hdrabkin/orgs","repos_url":"https://api.github.com/users/hdrabkin/repos","events_url":"https://api.github.com/users/hdrabkin/events{/privacy}","received_events_url":"https://api.github.com/users/hdrabkin/received_events","type":"User","site_admin":false}],"milestone":null,"comments":11,"created_at":"2018-05-03T21:49:40Z","updated_at":"2018-05-08T08:27:57Z","closed_at":null,"author_association":"NONE","body":"Accession GO:1990531\r\nNameLem3p-Dnf1p complex\r\ndef: A protein complex that functions as a phospholipid-translocating P-Type ATPase. \r\nSource: PMID:15090616, \r\nGOC:dph, GOC:rb\r\n\r\nThis definition does not seem to be specific enough for the term name , there are quite a few combinations of proteins that fit this definition.\r\n\r\nCould we make a more generic \"flippase\" complex term?  \r\n\r\nsee\r\nCoordinated Overexpression in Yeast of a P4-ATPase and Its Associated Cdc50 Subunit: The Case of the Drs2p/Cdc50p Lipid Flippase Complex.\r\nMethods Mol Biol. 2016;1377:37-55. \r\nPMID: 26695021\r\n\r\nA high-yield co-expression system for the purification of an intact Drs2p-Cdc50p lipid flippase complex, critically dependent on and stabilized by phosphatidylinositol-4-phosphate.\r\nPLoS One. 2014  PMID: 25393116\r\n\r\n\r\nThese complexes appear to have (at least one) member from each of these families \r\nIPR006539 | P-type ATPase, subfamily IV\r\nand a \r\nIPR005045 | CDC50/LEM3 family member\r\n\r\nIs it possible to say which way the flippase acts to refine the def?  (I think this one is external to internal PM membrane but I'm not completely sure, I'm guessing  because I have a flippase which is not either of these families and it seems to be  internal to external)\r\n\r\nthanks,\r\n\r\nval\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/387325897","html_url":"https://github.com/geneontology/go-ontology/issues/15693#issuecomment-387325897","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15693","id":387325897,"user":{"login":"bmeldal","id":10517124,"avatar_url":"https://avatars2.githubusercontent.com/u/10517124?v=4","gravatar_id":"","url":"https://api.github.com/users/bmeldal","html_url":"https://github.com/bmeldal","followers_url":"https://api.github.com/users/bmeldal/followers","following_url":"https://api.github.com/users/bmeldal/following{/other_user}","gists_url":"https://api.github.com/users/bmeldal/gists{/gist_id}","starred_url":"https://api.github.com/users/bmeldal/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/bmeldal/subscriptions","organizations_url":"https://api.github.com/users/bmeldal/orgs","repos_url":"https://api.github.com/users/bmeldal/repos","events_url":"https://api.github.com/users/bmeldal/events{/privacy}","received_events_url":"https://api.github.com/users/bmeldal/received_events","type":"User","site_admin":false},"created_at":"2018-05-08T08:27:57Z","updated_at":"2018-05-08T08:27:57Z","author_association":"NONE","body":"Ok, so transporter complex is correct then as is_a parent as it's defined for all types of transport.\r\n\r\nIn that case, this could be closed and I update the annotation in the CP."}}
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