{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/15251","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15251/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15251/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15251/events","html_url":"https://github.com/geneontology/go-ontology/issues/15251","id":299709249,"number":15251,"title":"Is 'peptidyl-diphthine' a real compund? ","user":{"login":"pgaudet","id":4782928,"avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"pgaudet","id":4782928,"avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"assignees":[{"login":"pgaudet","id":4782928,"avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false}],"milestone":null,"comments":2,"created_at":"2018-02-23T13:20:56Z","updated_at":"2018-02-24T13:06:26Z","closed_at":null,"author_association":"CONTRIBUTOR","body":"When I google it I only find GO terms. \r\n\r\nPerhaps we mean just 'diphthine'? I thought the peptidyl was used when the synthesis/modification occured within a protein. Here I dont think this is the case (for eg peptidyl-diphthine biosynthetic process from peptidyl-histidine has Def: The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine.\" \r\n\r\nwhich I think is produced by 'diphthine synthase activity' , 'Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.' \r\n\r\nSo it seems we should remove the 'peptidyl' from the term label ? \r\n\r\n\r\nApplies to \r\n\r\n'peptidyl-diphthine biosynthetic process from peptidyl-histidine' \r\n'peptidyl-diphthine catabolic process' \r\n'peptidyl-diphthine metabolic process' \r\nand possibly also to \r\n'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine'\r\n'peptidyl-diphthamide biosynthetic process from peptidyl-histidine'\r\n'peptidyl-thyronine biosynthetic process from peptidyl-tyrosine'\r\nanother potential PTM: \r\npeptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine\r\n\r\nThanks, Pascale"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/368227324","html_url":"https://github.com/geneontology/go-ontology/issues/15251#issuecomment-368227324","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/15251","id":368227324,"user":{"login":"pgaudet","id":4782928,"avatar_url":"https://avatars0.githubusercontent.com/u/4782928?v=4","gravatar_id":"","url":"https://api.github.com/users/pgaudet","html_url":"https://github.com/pgaudet","followers_url":"https://api.github.com/users/pgaudet/followers","following_url":"https://api.github.com/users/pgaudet/following{/other_user}","gists_url":"https://api.github.com/users/pgaudet/gists{/gist_id}","starred_url":"https://api.github.com/users/pgaudet/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pgaudet/subscriptions","organizations_url":"https://api.github.com/users/pgaudet/orgs","repos_url":"https://api.github.com/users/pgaudet/repos","events_url":"https://api.github.com/users/pgaudet/events{/privacy}","received_events_url":"https://api.github.com/users/pgaudet/received_events","type":"User","site_admin":false},"created_at":"2018-02-24T13:06:26Z","updated_at":"2018-02-24T13:06:26Z","author_association":"CONTRIBUTOR","body":"Thanks all ! \r\nWe seem to ahave two different term label patterns for PTMs: \r\n\r\n'peptidyl-lysine myristoylation'\r\n'peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine'\r\n\r\nI think the latter is confusing, I will reformulate as the former. \r\n\r\nPascale"}}
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