{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/11255","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11255/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11255/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11255/events","html_url":"https://github.com/geneontology/go-ontology/issues/11255","id":97267411,"node_id":"MDU6SXNzdWU5NzI2NzQxMQ==","number":11255,"title":"insulin secretion - always from pancreatic cells?","user":{"login":"gocentral","id":12972975,"node_id":"MDQ6VXNlcjEyOTcyOTc1","avatar_url":"https://avatars3.githubusercontent.com/u/12972975?v=4","gravatar_id":"","url":"https://api.github.com/users/gocentral","html_url":"https://github.com/gocentral","followers_url":"https://api.github.com/users/gocentral/followers","following_url":"https://api.github.com/users/gocentral/following{/other_user}","gists_url":"https://api.github.com/users/gocentral/gists{/gist_id}","starred_url":"https://api.github.com/users/gocentral/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/gocentral/subscriptions","organizations_url":"https://api.github.com/users/gocentral/orgs","repos_url":"https://api.github.com/users/gocentral/repos","events_url":"https://api.github.com/users/gocentral/events{/privacy}","received_events_url":"https://api.github.com/users/gocentral/received_events","type":"User","site_admin":false},"labels":[{"id":240251883,"node_id":"MDU6TGFiZWwyNDAyNTE4ODM=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/low%20priority","name":"low priority","color":"ededed","default":false},{"id":240600474,"node_id":"MDU6TGFiZWwyNDA2MDA0NzQ=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/metabolism","name":"metabolism","color":"fbca04","default":false}],"state":"open","locked":false,"assignee":{"login":"cmungall","id":50745,"node_id":"MDQ6VXNlcjUwNzQ1","avatar_url":"https://avatars1.githubusercontent.com/u/50745?v=4","gravatar_id":"","url":"https://api.github.com/users/cmungall","html_url":"https://github.com/cmungall","followers_url":"https://api.github.com/users/cmungall/followers","following_url":"https://api.github.com/users/cmungall/following{/other_user}","gists_url":"https://api.github.com/users/cmungall/gists{/gist_id}","starred_url":"https://api.github.com/users/cmungall/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/cmungall/subscriptions","organizations_url":"https://api.github.com/users/cmungall/orgs","repos_url":"https://api.github.com/users/cmungall/repos","events_url":"https://api.github.com/users/cmungall/events{/privacy}","received_events_url":"https://api.github.com/users/cmungall/received_events","type":"User","site_admin":false},"assignees":[{"login":"cmungall","id":50745,"node_id":"MDQ6VXNlcjUwNzQ1","avatar_url":"https://avatars1.githubusercontent.com/u/50745?v=4","gravatar_id":"","url":"https://api.github.com/users/cmungall","html_url":"https://github.com/cmungall","followers_url":"https://api.github.com/users/cmungall/followers","following_url":"https://api.github.com/users/cmungall/following{/other_user}","gists_url":"https://api.github.com/users/cmungall/gists{/gist_id}","starred_url":"https://api.github.com/users/cmungall/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/cmungall/subscriptions","organizations_url":"https://api.github.com/users/cmungall/orgs","repos_url":"https://api.github.com/users/cmungall/repos","events_url":"https://api.github.com/users/cmungall/events{/privacy}","received_events_url":"https://api.github.com/users/cmungall/received_events","type":"User","site_admin":false}],"milestone":null,"comments":5,"created_at":"2014-08-13T18:59:20Z","updated_at":"2018-10-02T07:45:06Z","closed_at":null,"author_association":"NONE","body":"```\n[Term]\nid: GO:0030073\nname: insulin secretion\ndef: \"The regulated release of proinsulin from ***secretory granules (B granules) in the B cells of the pancreas***; accompanied by cleavage of proinsulin to form mature insulin.\" [GOC:mah, ISBN:0198506732]\nis_a: GO:0030072 ! peptide hormone secretion\n```\n\nWe have a two annotations to regulation of insulin secretion in worm and fly.\n\nthe pancreas and proto-pancreas structures are vertebrate-specific PMID:16417468, but insulin is a billion years old:\n\nhttp://en.wikipedia.org/wiki/Insulin\n\nLooked at the drosophila annotation abstract, insulin is indeed being secreted:\nhttp://www.ncbi.nlm.nih.gov/pubmed/23874700\n\nThere are two possible courses of action here:\n1. Weak: alter text definition to be: \"The regulated release of insulin from a cell. In vertebrates, this is always from beta cells of the pancreas, and is accompanied by cleavage of the secreted proinsulin to form mature insulin\"\n2. Strong: change label to be \"insulin secretion from B cell\" and axiomatize accordingly. This will invalidate the 4 invert annotations. To accommodate, create a new grouping class \"insulin secretion\"\n\nNote that 1 could be accompanied by a taxon GCI as in uberon, but we don't use these in GO yet, and probably shouldn't until Protege 5.\n\nI would therefore vote for 2, even though this contributes to the drunk-christmas-tree effect.\n\nUse case driving decision: a user is looking for animal models of diabetes, or disorders involving pancreatic B cells. They query GO using the CL class, they get the specific GO class, which does not yield the FB gene. They have to go one level up (note this isn't necessary with the taxon-GCI route, but the query machinery is harder), e.g. via semantic similarity query, then they get the fly genes.\n\nReported by: cmungall\n\nOriginal Ticket: [geneontology/ontology-requests/11073](https://sourceforge.net/p/geneontology/ontology-requests/11073)\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/426180086","html_url":"https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426180086","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11255","id":426180086,"node_id":"MDEyOklzc3VlQ29tbWVudDQyNjE4MDA4Ng==","user":{"login":"hattrill","id":11865746,"node_id":"MDQ6VXNlcjExODY1NzQ2","avatar_url":"https://avatars1.githubusercontent.com/u/11865746?v=4","gravatar_id":"","url":"https://api.github.com/users/hattrill","html_url":"https://github.com/hattrill","followers_url":"https://api.github.com/users/hattrill/followers","following_url":"https://api.github.com/users/hattrill/following{/other_user}","gists_url":"https://api.github.com/users/hattrill/gists{/gist_id}","starred_url":"https://api.github.com/users/hattrill/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/hattrill/subscriptions","organizations_url":"https://api.github.com/users/hattrill/orgs","repos_url":"https://api.github.com/users/hattrill/repos","events_url":"https://api.github.com/users/hattrill/events{/privacy}","received_events_url":"https://api.github.com/users/hattrill/received_events","type":"User","site_admin":false},"created_at":"2018-10-02T07:45:06Z","updated_at":"2018-10-02T07:45:06Z","author_association":"NONE","body":"All of our annotations relate to release of insulin-like peptides from insulin-producing cells (IPCs) in the brain (in FBbt insulin secreting cell of pars intercerebralis FBbt:00004011). These behave like and are equivalent to vertebrate beta cells (ie respond to nutrient levels) and downstream the insulin-like peptides act like insulin. We have other cell-types that produce insulin-like peptides, but they are not part of the response to nutrients. \r\n"}}
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