{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/16704","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16704/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16704/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16704/events","html_url":"https://github.com/geneontology/go-ontology/issues/16704","id":384901668,"node_id":"MDU6SXNzdWUzODQ5MDE2Njg=","number":16704,"title":"ntr: processes in meiotic chromosome organization","user":{"login":"mah11","id":5196259,"node_id":"MDQ6VXNlcjUxOTYyNTk=","avatar_url":"https://avatars0.githubusercontent.com/u/5196259?v=4","gravatar_id":"","url":"https://api.github.com/users/mah11","html_url":"https://github.com/mah11","followers_url":"https://api.github.com/users/mah11/followers","following_url":"https://api.github.com/users/mah11/following{/other_user}","gists_url":"https://api.github.com/users/mah11/gists{/gist_id}","starred_url":"https://api.github.com/users/mah11/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mah11/subscriptions","organizations_url":"https://api.github.com/users/mah11/orgs","repos_url":"https://api.github.com/users/mah11/repos","events_url":"https://api.github.com/users/mah11/events{/privacy}","received_events_url":"https://api.github.com/users/mah11/received_events","type":"User","site_admin":false},"labels":[{"id":240250556,"node_id":"MDU6TGFiZWwyNDAyNTA1NTY=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/New%20term%20request","name":"New term request","color":"cdff8c","default":false},{"id":240257345,"node_id":"MDU6TGFiZWwyNDAyNTczNDU=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/PomBase","name":"PomBase","color":"bfd4f2","default":false},{"id":240585923,"node_id":"MDU6TGFiZWwyNDA1ODU5MjM=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/cell%20cycle%20and%20DNA%20processes","name":"cell cycle and DNA processes","color":"fbca04","default":false},{"id":407375226,"node_id":"MDU6TGFiZWw0MDczNzUyMjY=","url":"https://api.github.com/repos/geneontology/go-ontology/labels/community%20curation","name":"community curation","color":"c2e0c6","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2018-11-27T17:17:25Z","updated_at":"2018-11-27T17:42:54Z","closed_at":null,"author_association":"MEMBER","body":"We've received what amounts to a GO term request from Ayumu Yamamoto, who is doing community curation for PMID:27611693:\r\n\r\n\"We reported that a Taz1 fragment can induce centromere detachment from the SPB and kinetochore disassembly when it is artificially recruited to the SPB. ... I could not find appropriate terms for this.\"\r\n\r\nI haven't gone through the paper in depth, but I gather from what I have read of it that both processes are normal parts of the reorganization that puts chromosomes into the orientation characteristic of meiotic nuclear divisions, and that the fragment mentioned in the request is a construct used to test the normal role of Taz1. @ValWood may know more than I do about the broader processes, and we can also put you in touch with Ayumu directly if you have questions.\r\n\r\nIn the stanzas below, I've put the details I've been able to suss out, plus some questions and comments about the parts I'm less sure of:\r\n\r\nid: GO:new1\r\nname: centromere detachment from spindle pole body involved in meiotic chromosome organization\r\ndef: The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. [GOC:mah,PMID:27611693]\r\nsynonym: \"centromere detachment from SPB involved in meiotic chromosome organization\" EXACT []\r\nsynonym: \"centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle\" EXACT []\r\nis_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle\r\n* some relationship to GO:1990571 ! meiotic centromere clustering ?\r\n- centromeres have to detach from the SPB to be able to cluster away from it during meiosis, but whether the link is really part_of or \"precedes & required for\" isn't totally clear to me. \r\n- GO:0045141 ! meiotic telomere clustering also precedes GO:new1 - from the paper intro: centromeres are located at the SPB during mitotic interphase. Upon entering meiosis, telomeres cluster at the SPB, followed by centromere detachment from the SPB.\r\n\r\nid: GO:new2\r\nname: kinetochore disassembly involved in meiotic chromosome organization\r\ndef: The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. [GOC:mah,PMID:27611693]\r\nsynonym: \"kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle\" EXACT []\r\nis_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle\r\n- I guess this term could be made specific for the outer kinetochore (I have no strong preference)\r\n- Similar considerations for additional parentage as for GO:new1\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/442150992","html_url":"https://github.com/geneontology/go-ontology/issues/16704#issuecomment-442150992","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/16704","id":442150992,"node_id":"MDEyOklzc3VlQ29tbWVudDQ0MjE1MDk5Mg==","user":{"login":"srengel","id":13241825,"node_id":"MDQ6VXNlcjEzMjQxODI1","avatar_url":"https://avatars1.githubusercontent.com/u/13241825?v=4","gravatar_id":"","url":"https://api.github.com/users/srengel","html_url":"https://github.com/srengel","followers_url":"https://api.github.com/users/srengel/followers","following_url":"https://api.github.com/users/srengel/following{/other_user}","gists_url":"https://api.github.com/users/srengel/gists{/gist_id}","starred_url":"https://api.github.com/users/srengel/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/srengel/subscriptions","organizations_url":"https://api.github.com/users/srengel/orgs","repos_url":"https://api.github.com/users/srengel/repos","events_url":"https://api.github.com/users/srengel/events{/privacy}","received_events_url":"https://api.github.com/users/srengel/received_events","type":"User","site_admin":false},"created_at":"2018-11-27T17:42:54Z","updated_at":"2018-11-27T17:42:54Z","author_association":"NONE","body":"all sorts of proteins will mess up all sorts of processes is they are artificially recruited to the wrong place.  is this really something to capture in the GO?"}}
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