{"action":"opened","issue":{"url":"https://api.github.com/repos/clingen-data-model/clingen-interpretation/issues/241","repository_url":"https://api.github.com/repos/clingen-data-model/clingen-interpretation","labels_url":"https://api.github.com/repos/clingen-data-model/clingen-interpretation/issues/241/labels{/name}","comments_url":"https://api.github.com/repos/clingen-data-model/clingen-interpretation/issues/241/comments","events_url":"https://api.github.com/repos/clingen-data-model/clingen-interpretation/issues/241/events","html_url":"https://github.com/clingen-data-model/clingen-interpretation/issues/241","id":353042333,"node_id":"MDU6SXNzdWUzNTMwNDIzMzM=","number":241,"title":"base structure for gene dosage","user":{"login":"tnavatar","id":382512,"node_id":"MDQ6VXNlcjM4MjUxMg==","avatar_url":"https://avatars3.githubusercontent.com/u/382512?v=4","gravatar_id":"","url":"https://api.github.com/users/tnavatar","html_url":"https://github.com/tnavatar","followers_url":"https://api.github.com/users/tnavatar/followers","following_url":"https://api.github.com/users/tnavatar/following{/other_user}","gists_url":"https://api.github.com/users/tnavatar/gists{/gist_id}","starred_url":"https://api.github.com/users/tnavatar/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tnavatar/subscriptions","organizations_url":"https://api.github.com/users/tnavatar/orgs","repos_url":"https://api.github.com/users/tnavatar/repos","events_url":"https://api.github.com/users/tnavatar/events{/privacy}","received_events_url":"https://api.github.com/users/tnavatar/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2018-08-22T17:01:09Z","updated_at":"2018-08-22T17:01:09Z","closed_at":null,"author_association":"CONTRIBUTOR","body":"In subject, predicate, form, we would state a gene dosage assertion as:\r\n\r\nSubject: <GENE> SHANK3\r\nPredicate: with reduced dosage, is pathogenic for\r\nObject: <CONDITION> Phelan-McDermid Syndrome\r\n\r\nvs\r\n\r\nstmt 1:\r\nVariation Class\r\nSubject: <GENE> SHANK3\r\nPredicate: has dosage\r\nObject: 1 | reduced\r\n\r\nstmt 2:\r\nAssertion:\r\nSubject: stmt 1\r\nPredicate: is pathogenic for\r\nObject: <CONDITION>\r\n\r\nhttps://www.ncbi.nlm.nih.gov/projects/dbvar/clingen/clingen_gene.cgi?sym=SHANK3"}}
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