{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12671","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12671/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12671/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12671/events","html_url":"https://github.com/geneontology/go-ontology/issues/12671","id":178537381,"number":12671,"title":"adaptive immune response","user":{"login":"nnouspikel","id":17926841,"avatar_url":"https://avatars.githubusercontent.com/u/17926841?v=3","gravatar_id":"","url":"https://api.github.com/users/nnouspikel","html_url":"https://github.com/nnouspikel","followers_url":"https://api.github.com/users/nnouspikel/followers","following_url":"https://api.github.com/users/nnouspikel/following{/other_user}","gists_url":"https://api.github.com/users/nnouspikel/gists{/gist_id}","starred_url":"https://api.github.com/users/nnouspikel/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/nnouspikel/subscriptions","organizations_url":"https://api.github.com/users/nnouspikel/orgs","repos_url":"https://api.github.com/users/nnouspikel/repos","events_url":"https://api.github.com/users/nnouspikel/events{/privacy}","received_events_url":"https://api.github.com/users/nnouspikel/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"assignees":[{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false}],"milestone":null,"comments":13,"created_at":"2016-09-22T07:04:37Z","updated_at":"2016-11-09T20:12:26Z","closed_at":null,"body":"Dear GO annotators,\nI am annotating the immune genes and would like to solicit your help to better define the adaptive immune response in GO.\nSpecifically:\n1. I would suggest updating the definition of GO:0002250 adaptive immune response so that it encompasses both the primary and the secondary immune responses of adaptive immunity. I’d suggest quoting Roitt’s textbook of immunology (http://www.roitt.com/) for the definition: “Adaptive immune response is immunity mediated by lymphocytes and characterized by antigen specificity and memory. The first encounter with antigen elicits a primary immune response that is rather slow and not of great magnitude. T and B lymphocytes selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive lymphocytes become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon antigen rechallenge’’.\n2. I feel there is a need to create two GO terms that would distinguish effector functions and immune memory, which as mentioned above are two distinct elements of the adaptive immune response. This is a request from immunologists involved in our project.\nMay I suggest creating the following GO terms:\nGO:1990982: adaptive immune memory response (previously submitted by Sylvain)\ndefinition: The immune response against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. Quoting Zinkernagel in PMID:26831526\nGO:xxx: adaptive immune effector response\ndefinition: Cellular and humoral immune response that takes place during the effector phase of the adaptive immune response. In the case of B lymphocytes, the effector cells are the antibody-secreting plasma cells whereas for T-lymphocytes the effector cells may be T-helper cells, cytotoxic T-cells or regulatory T cells. Quoting Roitt’s textbook of immunology (http://www.roitt.com/)\n\nThank you in advance for your help,\n\nNevila Hyka-Nouspikel\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/259513949","html_url":"https://github.com/geneontology/go-ontology/issues/12671#issuecomment-259513949","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12671","id":259513949,"user":{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"created_at":"2016-11-09T20:12:26Z","updated_at":"2016-11-09T20:12:26Z","body":"Thank you very much @addiehl .  @nnouspikel, please review.  If this is acceptable, I will implement the suggested changes."}}
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