{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12548","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12548/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12548/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12548/events","html_url":"https://github.com/geneontology/go-ontology/issues/12548","id":166320102,"number":12548,"title":"need to look at “endosomal secretion” too","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/PomBase","name":"PomBase","color":"bfd4f2"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/vesicle_mediated_transport","name":"vesicle_mediated_transport","color":"e99695"}],"state":"open","locked":false,"assignee":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"assignees":[{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false}],"milestone":null,"comments":2,"created_at":"2016-07-19T12:35:14Z","updated_at":"2016-07-21T20:38:03Z","closed_at":null,"body":"\r\nQuestion, in yeast are exosomes contained within a MVB?\r\nhttp://www.ebi.ac.uk/QuickGO/GTerm?id=GO:1990182\r\nthe term “exosomal secretion” is defined in terms of the MVB/multivesicular body fusion\r\n\r\nThere are 16 EXP annotations\r\n9 from a fly paper which says this in the abstract:\r\n This signaling is involved in blocking the rapid remating of mated females, which contributes to the reproductive advantage of the first male to mate. In this paper, we show that SCs secrete exosomes, membrane-bound vesicles generated inside late endosomal multivesicular bodies (MVBs).\r\nThis doesn’t sound as thought the MVB itself fuses this the PM, but MVB derived vesicles.\r\n\r\nAlthough this paper implies that it is\r\nhttp://europepmc.org/abstract/MED/26459596\r\nCould this term be more clearly defined to indicate exosomal fusion via MVB? Has this  direct fusion been demonstrated directly? lots of the pictures seem to  display it in this way...\r\n\r\nThe way this is defined and placed will depend upon\r\ni) whether the MVB fuses with the membrane and releases exosomal\r\nor \r\nii)  whether the exosomal vesicles leave the MVB before fusion with the membrane\r\n\r\nI also need to find out what happens in yeast. I thought that  exosomal vesicles left the endosome, but it might be that the process is similar to that described above.   I can check up on this...\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/234376518","html_url":"https://github.com/geneontology/go-ontology/issues/12548#issuecomment-234376518","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12548","id":234376518,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2016-07-21T20:38:03Z","updated_at":"2016-07-21T20:38:03Z","body":"Maybe the issue here is simple. Perhaps just the term name needs to be changed (all exocytosis is 'exosomal secretion' right, not only when an MVB  fuses with the PM?)"}}
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