{"action":"opened","issue":{"url":"https://api.github.com/repos/rdkit/rdkit/issues/1233","repository_url":"https://api.github.com/repos/rdkit/rdkit","labels_url":"https://api.github.com/repos/rdkit/rdkit/issues/1233/labels{/name}","comments_url":"https://api.github.com/repos/rdkit/rdkit/issues/1233/comments","events_url":"https://api.github.com/repos/rdkit/rdkit/issues/1233/events","html_url":"https://github.com/rdkit/rdkit/issues/1233","id":197771733,"number":1233,"title":"Embed Conformer failures","user":{"login":"proteneer","id":2280724,"avatar_url":"https://avatars.githubusercontent.com/u/2280724?v=3","gravatar_id":"","url":"https://api.github.com/users/proteneer","html_url":"https://github.com/proteneer","followers_url":"https://api.github.com/users/proteneer/followers","following_url":"https://api.github.com/users/proteneer/following{/other_user}","gists_url":"https://api.github.com/users/proteneer/gists{/gist_id}","starred_url":"https://api.github.com/users/proteneer/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/proteneer/subscriptions","organizations_url":"https://api.github.com/users/proteneer/orgs","repos_url":"https://api.github.com/users/proteneer/repos","events_url":"https://api.github.com/users/proteneer/events{/privacy}","received_events_url":"https://api.github.com/users/proteneer/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2016-12-27T23:29:42Z","updated_at":"2016-12-27T23:29:42Z","closed_at":null,"body":"Rather ordinary looking molecule. Changing either the left or the right most chiral centers allows embedding to work. Changing the middle chiral center makes no difference. I've also tried all the other args, including setting various settings of enforcing stereo.\r\n\r\nAny ideas?\r\n\r\n```\r\nprint(AllChem.EmbedMolecule(Chem.MolFromSmiles(\"OC[C@H](O)[C@@H](O)[C@H](O)CO\")))\r\nprint(AllChem.EmbedMolecule(Chem.MolFromSmiles(\"OC[C@H](O)[CH](O)[C@H](O)CO\")))\r\nprint(AllChem.EmbedMolecule(Chem.MolFromSmiles(\"OC[CH](O)[C@@H](O)[C@H](O)CO\")))\r\nprint(AllChem.EmbedMolecule(Chem.MolFromSmiles(\"OC[C@H](O)[C@@H](O)[CH](O)CO\")))\r\n\r\n>> -1\r\n>> -1\r\n>> 0\r\n>> 0\r\n```"}}
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