{"action":"closed","issue":{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/374","repository_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List","labels_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/374/labels{/name}","comments_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/374/comments","events_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/374/events","html_url":"https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/374","id":139177811,"number":374,"title":"Sydney Grammar School Daraprim Synthesis","user":{"login":"alintheopen","id":2626599,"avatar_url":"https://avatars.githubusercontent.com/u/2626599?v=3","gravatar_id":"","url":"https://api.github.com/users/alintheopen","html_url":"https://github.com/alintheopen","followers_url":"https://api.github.com/users/alintheopen/followers","following_url":"https://api.github.com/users/alintheopen/following{/other_user}","gists_url":"https://api.github.com/users/alintheopen/gists{/gist_id}","starred_url":"https://api.github.com/users/alintheopen/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/alintheopen/subscriptions","organizations_url":"https://api.github.com/users/alintheopen/orgs","repos_url":"https://api.github.com/users/alintheopen/repos","events_url":"https://api.github.com/users/alintheopen/events{/privacy}","received_events_url":"https://api.github.com/users/alintheopen/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Being%20Synthesised%20Now","name":"Being Synthesised Now","color":"eb6420"},{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Daraprim","name":"Daraprim","color":"5319e7"},{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Synthetic%20Chemistry%20Needed","name":"Synthetic Chemistry Needed","color":"d4c5f9"}],"state":"closed","locked":false,"assignee":{"login":"ErinSheridan","id":8910793,"avatar_url":"https://avatars.githubusercontent.com/u/8910793?v=3","gravatar_id":"","url":"https://api.github.com/users/ErinSheridan","html_url":"https://github.com/ErinSheridan","followers_url":"https://api.github.com/users/ErinSheridan/followers","following_url":"https://api.github.com/users/ErinSheridan/following{/other_user}","gists_url":"https://api.github.com/users/ErinSheridan/gists{/gist_id}","starred_url":"https://api.github.com/users/ErinSheridan/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ErinSheridan/subscriptions","organizations_url":"https://api.github.com/users/ErinSheridan/orgs","repos_url":"https://api.github.com/users/ErinSheridan/repos","events_url":"https://api.github.com/users/ErinSheridan/events{/privacy}","received_events_url":"https://api.github.com/users/ErinSheridan/received_events","type":"User","site_admin":false},"assignees":[{"login":"ErinSheridan","id":8910793,"avatar_url":"https://avatars.githubusercontent.com/u/8910793?v=3","gravatar_id":"","url":"https://api.github.com/users/ErinSheridan","html_url":"https://github.com/ErinSheridan","followers_url":"https://api.github.com/users/ErinSheridan/followers","following_url":"https://api.github.com/users/ErinSheridan/following{/other_user}","gists_url":"https://api.github.com/users/ErinSheridan/gists{/gist_id}","starred_url":"https://api.github.com/users/ErinSheridan/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ErinSheridan/subscriptions","organizations_url":"https://api.github.com/users/ErinSheridan/orgs","repos_url":"https://api.github.com/users/ErinSheridan/repos","events_url":"https://api.github.com/users/ErinSheridan/events{/privacy}","received_events_url":"https://api.github.com/users/ErinSheridan/received_events","type":"User","site_admin":false}],"milestone":null,"comments":65,"created_at":"2016-03-08T04:32:47Z","updated_at":"2016-10-25T10:26:05Z","closed_at":"2016-10-25T10:26:05Z","body":"As decided in issue #311, Sydney Grammar School Students are attempting to synthesise Daraprim at School. Background below is edited from issue #311 \r\n\r\nThis molecule received a lot of press back in 2015 owing to the price hiking over in the USA. Turing pharmaceuticals wanted to raise the price from $13.50 to $750 per dose. Public and media outcry led the company to reconsider the pricing options but a synthesis in the open would be great to see. Daraprim was originally synthesised as an antimalarial (by Nobel prize winner Gertrude Elion) and is now used in combination with a sulfonamide for the treatment of toxoplasmosis.\r\n\r\nThe students could synthesise pyrimethamine using the route highlighted below (nabbed from Wikipedia https://en.wikipedia.org/wiki/Pyrimethamine) and with supporting evidence found in the literature. Stronger bases are typically used for step one, and some routes use diazo compounds for step 2, but I think this method looks quite robust and uses reagents that are accessible and could be handled by the students, under your supervision of course. We could potentially test all compounds against malaria (after designing some novel analogs), TB and also against toxoplasma gondii if we can set up a collaboration.\r\n\r\n![daraprim_num_update](https://cloud.githubusercontent.com/assets/2626599/13592775/8074f52c-e549-11e5-96a7-20559a79d6ee.png)\r\n\r\n"}}
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