{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12789","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12789/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12789/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12789/events","html_url":"https://github.com/geneontology/go-ontology/issues/12789","id":188215755,"number":12789,"title":"NTR for Sca1 protein complex","user":{"login":"rjdodson","id":1750323,"avatar_url":"https://avatars.githubusercontent.com/u/1750323?v=3","gravatar_id":"","url":"https://api.github.com/users/rjdodson","html_url":"https://github.com/rjdodson","followers_url":"https://api.github.com/users/rjdodson/followers","following_url":"https://api.github.com/users/rjdodson/following{/other_user}","gists_url":"https://api.github.com/users/rjdodson/gists{/gist_id}","starred_url":"https://api.github.com/users/rjdodson/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/rjdodson/subscriptions","organizations_url":"https://api.github.com/users/rjdodson/orgs","repos_url":"https://api.github.com/users/rjdodson/repos","events_url":"https://api.github.com/users/rjdodson/events{/privacy}","received_events_url":"https://api.github.com/users/rjdodson/received_events","type":"User","site_admin":false},"labels":[{"id":478208409,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/editors-discussion","name":"editors-discussion","color":"d4c5f9","default":false}],"state":"open","locked":false,"assignee":{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false},"assignees":[{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false}],"milestone":null,"comments":10,"created_at":"2016-11-09T10:42:56Z","updated_at":"2016-11-17T10:15:41Z","closed_at":null,"body":"Hello:\r\nI would like to request a new GO component term for a protein complex identified in Dictyostelium discoideum. \r\n\r\nName: Sca1 complex\r\n\r\nOntology: cellular_component\r\n\r\nSynonyms: Ras signaling complex, Sca1 signaling complex\r\n\r\nDefinition: A multi-protein complex which functions biologically to control the RasC-TorC2 pathway and thereby regulate cell motility, chemotaxis, and the relay of the cAMP chemoattractant signal in Dictyostelium cells. The core components of the Sca1 complex are the Ras guanine exchange factor (RasGEF) Aimless, RasGEFH, protein phosphatase 2A subunit A (PP2A), and a scaffold protein designated Sca1, and also including the pleckstrin homology domain protein PHR and protein phosphatase PP2A-C2.\r\n\r\nThe position of this term in the GO hierarchy should be as a child of:\r\n\r\nGO:0043234   protein complex\r\n\r\nReferences:\r\nPMID:20493808, A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.\r\n\r\nSee Fig. 1K in the above reference for a diagram of the complex. Please let me know if you have any questions. \r\nBob Dodson"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/261208154","html_url":"https://github.com/geneontology/go-ontology/issues/12789#issuecomment-261208154","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12789","id":261208154,"user":{"login":"rjdodson","id":1750323,"avatar_url":"https://avatars.githubusercontent.com/u/1750323?v=3","gravatar_id":"","url":"https://api.github.com/users/rjdodson","html_url":"https://github.com/rjdodson","followers_url":"https://api.github.com/users/rjdodson/followers","following_url":"https://api.github.com/users/rjdodson/following{/other_user}","gists_url":"https://api.github.com/users/rjdodson/gists{/gist_id}","starred_url":"https://api.github.com/users/rjdodson/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/rjdodson/subscriptions","organizations_url":"https://api.github.com/users/rjdodson/orgs","repos_url":"https://api.github.com/users/rjdodson/repos","events_url":"https://api.github.com/users/rjdodson/events{/privacy}","received_events_url":"https://api.github.com/users/rjdodson/received_events","type":"User","site_admin":false},"created_at":"2016-11-17T10:15:41Z","updated_at":"2016-11-17T10:15:41Z","body":"Hi Birgit:\r\n\r\nThanks for your comment-just two follow-up points from me.\r\nFirst, it may be important to note that the Ras guanyl-nucleotide exchange activity function is based on IMP evidence. That is, this activity for these proteins is inferred by me based on a process phenotype-which I have curated as positive regulation of Ras protein signal transduction. There is no IDA evidence that gefA and gefH have this activity. I think this is allowed annotation practice, but I am always hesitant to curate MF terms using IMP as ev_code. \r\nSecond, I completely agree with David's concern about too many species-specific component terms (same for MF and BP terms too). An inflated and unwieldy ontology is in no one's best interests. So if you'd prefer me to add this just to the complex portal instead, I'm fine with that. \r\n\r\nLet me know, and in the meantime I'll try and poke around a bit in the complex portal if I have time. \r\n\r\nThanks,\r\nBob"}}
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