{"action":"created","issue":{"url":"https://api.github.com/repos/obophenotype/cell-ontology/issues/448","repository_url":"https://api.github.com/repos/obophenotype/cell-ontology","labels_url":"https://api.github.com/repos/obophenotype/cell-ontology/issues/448/labels{/name}","comments_url":"https://api.github.com/repos/obophenotype/cell-ontology/issues/448/comments","events_url":"https://api.github.com/repos/obophenotype/cell-ontology/issues/448/events","html_url":"https://github.com/obophenotype/cell-ontology/issues/448","id":181225714,"number":448,"title":"NTR: cancer cell","user":{"login":"markwoon","id":215141,"avatar_url":"https://avatars.githubusercontent.com/u/215141?v=3","gravatar_id":"","url":"https://api.github.com/users/markwoon","html_url":"https://github.com/markwoon","followers_url":"https://api.github.com/users/markwoon/followers","following_url":"https://api.github.com/users/markwoon/following{/other_user}","gists_url":"https://api.github.com/users/markwoon/gists{/gist_id}","starred_url":"https://api.github.com/users/markwoon/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/markwoon/subscriptions","organizations_url":"https://api.github.com/users/markwoon/orgs","repos_url":"https://api.github.com/users/markwoon/repos","events_url":"https://api.github.com/users/markwoon/events{/privacy}","received_events_url":"https://api.github.com/users/markwoon/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":10,"created_at":"2016-10-05T18:06:47Z","updated_at":"2016-10-27T18:50:27Z","closed_at":null,"body":"label: cancer cell\r\ndefinition: A cell that has undergone transformation to become cancerous.\r\nis_a: CL_0000000 (cell)"},"comment":{"url":"https://api.github.com/repos/obophenotype/cell-ontology/issues/comments/256735079","html_url":"https://github.com/obophenotype/cell-ontology/issues/448#issuecomment-256735079","issue_url":"https://api.github.com/repos/obophenotype/cell-ontology/issues/448","id":256735079,"user":{"login":"addiehl","id":11201751,"avatar_url":"https://avatars.githubusercontent.com/u/11201751?v=3","gravatar_id":"","url":"https://api.github.com/users/addiehl","html_url":"https://github.com/addiehl","followers_url":"https://api.github.com/users/addiehl/followers","following_url":"https://api.github.com/users/addiehl/following{/other_user}","gists_url":"https://api.github.com/users/addiehl/gists{/gist_id}","starred_url":"https://api.github.com/users/addiehl/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/addiehl/subscriptions","organizations_url":"https://api.github.com/users/addiehl/orgs","repos_url":"https://api.github.com/users/addiehl/repos","events_url":"https://api.github.com/users/addiehl/events{/privacy}","received_events_url":"https://api.github.com/users/addiehl/received_events","type":"User","site_admin":false},"created_at":"2016-10-27T18:50:27Z","updated_at":"2016-10-27T18:50:27Z","body":"Here are some proposed definitions for the cell types ‘abnormal cell’, ‘neoplastic cell’, ‘malignant cell’, developed by me and William Duncan and Carmelo Gaudioso of the Roswell Park Cancer Institute.\r\n\r\nabnormal cell: A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism.  Abnormal cells are typically found in disease states or disease models.\r\n\r\nneoplastic cell: An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism.\r\n\r\nmalignant cell: A neoplastic cell that is capable of entering a surrounding tissue or metastasizing to a regional or distant bodily location.\r\n\r\nNotes:  The labels are identical to the NCIT labels, but the definitions are substantially different.  The NCIT definition of  ‘Abnormal Cell’, “An abnormal human cell type which can occur in either disease states or disease models,” makes no attempt to define what abnormality means in this context, and defines this cell type as necessarily human, which is far too restrictive for the CL.  As this is the parent of the other two cell types, this is not appropriate.\r\n\r\nWe define ‘neoplastic cell’ based on its specific phentotype, rather than its origin.  The NCIT definition of ‘Neoplastic Cell’, “Cells of, or derived from, a tumor,” is unnecessarily broad in that normal cell types can be found in tumors (vascular cells, TILs, etc.), but also too restrictive, as neoplastic cells can occur outside of tumors.\r\n\r\nWe define ‘malignant cell’ in reference to the definition of the NCIT term ‘Malignant’, “Cancerous. Malignant cells can invade and destroy nearby tissue and spread to other parts of the body,” rather than the NCIT term ‘Malignant Cell’, “Cells of, or derived from, a malignant tumor.”\r\n\r\nWe welcome comments on the suggested definitions for these cell types.\r\n\r\nThanks,\r\nAlex\r\n"}}
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