{"action":"created","issue":{"url":"https://api.github.com/repos/SamStudio8/gretel/issues/3","repository_url":"https://api.github.com/repos/SamStudio8/gretel","labels_url":"https://api.github.com/repos/SamStudio8/gretel/issues/3/labels{/name}","comments_url":"https://api.github.com/repos/SamStudio8/gretel/issues/3/comments","events_url":"https://api.github.com/repos/SamStudio8/gretel/issues/3/events","html_url":"https://github.com/SamStudio8/gretel/issues/3","id":184715432,"number":3,"title":"Is the intuition for `L` correct?","user":{"login":"SamStudio8","id":1105722,"avatar_url":"https://avatars.githubusercontent.com/u/1105722?v=3","gravatar_id":"","url":"https://api.github.com/users/SamStudio8","html_url":"https://github.com/SamStudio8","followers_url":"https://api.github.com/users/SamStudio8/followers","following_url":"https://api.github.com/users/SamStudio8/following{/other_user}","gists_url":"https://api.github.com/users/SamStudio8/gists{/gist_id}","starred_url":"https://api.github.com/users/SamStudio8/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/SamStudio8/subscriptions","organizations_url":"https://api.github.com/users/SamStudio8/orgs","repos_url":"https://api.github.com/users/SamStudio8/repos","events_url":"https://api.github.com/users/SamStudio8/events{/privacy}","received_events_url":"https://api.github.com/users/SamStudio8/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/SamStudio8/gretel/labels/question","name":"question","color":"cc317c"}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":1,"created_at":"2016-10-23T21:00:26Z","updated_at":"2016-10-23T21:09:40Z","closed_at":null,"body":"`L` is set to be the average number of SNPs covered by all parsed aligned reads. In regions where the value of `L` turns out to be greater than the evidence available, is performance damaged?\r\nMy guess is no, as evidence will be lacking across all options (symbols) for that particular (i, j) symbol pair, and thus there won't be any bias towards selection - but does this make comparing the likelihoods of paths more difficult?\r\n\r\nCould we instead use a varying L? Would that improve performance?\r\n...How sensitive is L anyway?"},"comment":{"url":"https://api.github.com/repos/SamStudio8/gretel/issues/comments/255614599","html_url":"https://github.com/SamStudio8/gretel/issues/3#issuecomment-255614599","issue_url":"https://api.github.com/repos/SamStudio8/gretel/issues/3","id":255614599,"user":{"login":"SamStudio8","id":1105722,"avatar_url":"https://avatars.githubusercontent.com/u/1105722?v=3","gravatar_id":"","url":"https://api.github.com/users/SamStudio8","html_url":"https://github.com/SamStudio8","followers_url":"https://api.github.com/users/SamStudio8/followers","following_url":"https://api.github.com/users/SamStudio8/following{/other_user}","gists_url":"https://api.github.com/users/SamStudio8/gists{/gist_id}","starred_url":"https://api.github.com/users/SamStudio8/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/SamStudio8/subscriptions","organizations_url":"https://api.github.com/users/SamStudio8/orgs","repos_url":"https://api.github.com/users/SamStudio8/repos","events_url":"https://api.github.com/users/SamStudio8/events{/privacy}","received_events_url":"https://api.github.com/users/SamStudio8/received_events","type":"User","site_admin":false},"created_at":"2016-10-23T21:09:40Z","updated_at":"2016-10-23T21:09:40Z","body":"In the case where more than `L` pairs of evidence exist, is there quantifiable loss in performance by only considering `L` pairs of evidence? In the case where fewer than `L` pairs of evidence exist, does the smoothing have a non-negligible affect on performance?"}}
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