{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12853","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12853/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12853/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12853/events","html_url":"https://github.com/geneontology/go-ontology/issues/12853","id":193294397,"number":12853,"title":"issues with cap binding complexes","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":1,"created_at":"2016-12-03T15:40:24Z","updated_at":"2016-12-03T15:46:29Z","closed_at":null,"body":"\r\n\r\ncurrent arrangement\r\nRNA cap binding complex\r\n--mRNA cap binding complex\r\n----GO:0098745\tDcp1-Dcp2 complex\r\n----GO:0034519\tcytoplasmic RNA cap binding complex\r\n--nuclear cap binding complex\r\n\r\nHowever there don't appear to be any cap binding complexes specific for mRNAs ..the  nuclear cap binding complex members could also be annotated to the  sibling term mRNA cap binding complex.\r\nIn fact nuclear cap binding complex has\r\nnarrow\tmRNA cap binding complex\r\n\r\n - [ ]   obsolete  \"mRNA cap binding complex\"\r\n- [ ]  GO:0098745\tDcp1-Dcp2 complex is_a GO:0034519\r\n- [ ]  nuclear cap binding complex is defined to use for a very specific complex (CBC), \r\nrename CBC cap binding complex (it isn't restricted to the nucleus, so the name is confusing)\r\n\r\n\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/264646630","html_url":"https://github.com/geneontology/go-ontology/issues/12853#issuecomment-264646630","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12853","id":264646630,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2016-12-03T15:46:29Z","updated_at":"2016-12-03T15:46:29Z","body":"Finally this def needs updating\r\nA conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.\r\n\r\nA conserved heterotrimeric protein\r\nScrub: The consists of proteins known as CBP20 and CBP80\r\nReplace with Human members are NCBP1-3\r\n\r\n\r\n\r\n\r\n"}}
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