{"action":"opened","issue":{"url":"https://api.github.com/repos/statgenlmu/coala/issues/161","repository_url":"https://api.github.com/repos/statgenlmu/coala","labels_url":"https://api.github.com/repos/statgenlmu/coala/issues/161/labels{/name}","comments_url":"https://api.github.com/repos/statgenlmu/coala/issues/161/comments","events_url":"https://api.github.com/repos/statgenlmu/coala/issues/161/events","html_url":"https://github.com/statgenlmu/coala/issues/161","id":141016181,"number":161,"title":"Support for (systematic) variation of mutation rates across loci?","user":{"login":"andrewparkermorgan","id":6525073,"avatar_url":"https://avatars.githubusercontent.com/u/6525073?v=3","gravatar_id":"","url":"https://api.github.com/users/andrewparkermorgan","html_url":"https://github.com/andrewparkermorgan","followers_url":"https://api.github.com/users/andrewparkermorgan/followers","following_url":"https://api.github.com/users/andrewparkermorgan/following{/other_user}","gists_url":"https://api.github.com/users/andrewparkermorgan/gists{/gist_id}","starred_url":"https://api.github.com/users/andrewparkermorgan/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/andrewparkermorgan/subscriptions","organizations_url":"https://api.github.com/users/andrewparkermorgan/orgs","repos_url":"https://api.github.com/users/andrewparkermorgan/repos","events_url":"https://api.github.com/users/andrewparkermorgan/events{/privacy}","received_events_url":"https://api.github.com/users/andrewparkermorgan/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":0,"created_at":"2016-03-15T15:51:07Z","updated_at":"2016-03-15T15:51:07Z","closed_at":null,"body":"Does `coala` provide a means for setting locus-specific mutation rates?  I think `par_variation()` is close to what I want, only I would prefer to specify the deviation from the parent parameter rather than drawing it from a gamma distribution.\r\n\r\nThis would be useful for simulating, for instance, an autosomal and a sex-chromosome locus -- which have different effective population sizes -- in the same scenario.  My specific interest is in using `coala` in an ABC pipeline for estimating the ratio between the two locus-specific thetas.\r\n\r\nIf you can provide some guidance on a possible implementation, I am happy to write something up and submit a pull request."}}