{"action":"created","issue":{"url":"https://api.github.com/repos/evidenceontology/evidenceontology/issues/118","repository_url":"https://api.github.com/repos/evidenceontology/evidenceontology","labels_url":"https://api.github.com/repos/evidenceontology/evidenceontology/issues/118/labels{/name}","comments_url":"https://api.github.com/repos/evidenceontology/evidenceontology/issues/118/comments","events_url":"https://api.github.com/repos/evidenceontology/evidenceontology/issues/118/events","html_url":"https://github.com/evidenceontology/evidenceontology/issues/118","id":191310418,"number":118,"title":"NTR under electrophysiology evidence - whole-cell patch-clamp evidence","user":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"labels":[],"state":"closed","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":5,"created_at":"2016-11-23T15:51:49Z","updated_at":"2016-12-07T15:11:41Z","closed_at":"2016-12-07T15:11:41Z","body":"whole-cell patch-clamp\r\n\r\nSynGO suggests: High resolution single cell recordings of whole cell currents, membrane potentials or cell capacitance.\r\nPMID:6143532 http://www.springer.com/us/book/9780306448706\r\n\r\nWikipedia entry looks useful for more experimental details: https://en.wikipedia.org/wiki/Patch_clamp#Whole-cell_recording_or_whole-cell_patch that might align more closely with defs for related terms you already have:\r\n\r\ne.g.\r\n\r\nrdfs:label \"cell-attached single-channel recording evidence\"\r\nid \"ECO:0005573\"\r\ndefinition \"A type of electrophysiology assay evidence that involves isolation of a patch of membrane electrically from the external solution and to record current flowing into the patch and this is achieved by pressing a fire-polished glass pipette, which has been filled with a suitable electrolyte solution, against the surface of a cell and applying light suction.\"\r\n\r\nIt may also be worth adding a general class for patch clamp evidence covering whole cell, cell attached etc.  See https://en.wikipedia.org/wiki/Patch_clamp for mappings to current terms (chase up original refs from WP wherever poss!)\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/evidenceontology/evidenceontology/issues/comments/265472374","html_url":"https://github.com/evidenceontology/evidenceontology/issues/118#issuecomment-265472374","issue_url":"https://api.github.com/repos/evidenceontology/evidenceontology/issues/118","id":265472374,"user":{"login":"rctauber","id":16750150,"avatar_url":"https://avatars.githubusercontent.com/u/16750150?v=3","gravatar_id":"","url":"https://api.github.com/users/rctauber","html_url":"https://github.com/rctauber","followers_url":"https://api.github.com/users/rctauber/followers","following_url":"https://api.github.com/users/rctauber/following{/other_user}","gists_url":"https://api.github.com/users/rctauber/gists{/gist_id}","starred_url":"https://api.github.com/users/rctauber/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/rctauber/subscriptions","organizations_url":"https://api.github.com/users/rctauber/orgs","repos_url":"https://api.github.com/users/rctauber/repos","events_url":"https://api.github.com/users/rctauber/events{/privacy}","received_events_url":"https://api.github.com/users/rctauber/received_events","type":"User","site_admin":false},"created_at":"2016-12-07T15:11:41Z","updated_at":"2016-12-07T15:11:41Z","body":"Going to go ahead and close this since the terms have been added in. Please let me know if there are any other issues."}}
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