{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12878","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12878/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12878/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12878/events","html_url":"https://github.com/geneontology/go-ontology/issues/12878","id":196526238,"number":12878,"title":"ER membrane targeting","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false},"assignees":[{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false}],"milestone":null,"comments":2,"created_at":"2016-12-19T21:34:41Z","updated_at":"2016-12-20T14:04:04Z","closed_at":null,"body":"\r\nI want to annotate a GP which is involved in post translational targetting to ER membrane.\r\n\r\nThere are 2 applicable terms, in different branches\r\n\r\nprotein targeting to ER; GOid=GO:0045047\r\nposttranslational protein targeting to membrane\r\n\r\nIs it possible to have a term which captures all features of both?\r\n\r\nThanks\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/268250611","html_url":"https://github.com/geneontology/go-ontology/issues/12878#issuecomment-268250611","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12878","id":268250611,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2016-12-20T14:04:04Z","updated_at":"2016-12-20T14:04:04Z","body":"https://www.ncbi.nlm.nih.gov/pubmed/19956640\r\nhttps://www.ncbi.nlm.nih.gov/pubmed/18724936\r\n\r\nCan we make it clear that the targeting process is only for delivery/insertion to the ER (cytoplasmic side) ?\r\n\r\nThis is the pathway for GPs which can't be localized by the SRP because the localization signal  for the GP's which are  attached to the external side of the membrane are in  C-term rather than the N-term. I assume the separation of the signal sequences is an evolutionary mechanism to ensure that resident/integral to ER side, or inserted  into cytoplasmic side go via the correct route.\r\n\r\n\"post-translational targeting to ER membrane\" would appear to cover ?\r\n\r\nI'm not sure of the GET complex targets but I am assuming it is things like the Sre1 cleavage activating protein and sterol regulatory element binding protein, transcription factor Sre1\r\nwhich are external to the ER membrane. The trafficked proteins are internal aren't they (lumen or membrane)? or is that not always the case\r\n\r\n"}}
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