{"action":"created","issue":{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/379","repository_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List","labels_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/379/labels{/name}","comments_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/379/comments","events_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/379/events","html_url":"https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/379","id":147910716,"number":379,"title":"Cubane?","user":{"login":"mattodd","id":4386101,"avatar_url":"https://avatars.githubusercontent.com/u/4386101?v=3","gravatar_id":"","url":"https://api.github.com/users/mattodd","html_url":"https://github.com/mattodd","followers_url":"https://api.github.com/users/mattodd/followers","following_url":"https://api.github.com/users/mattodd/following{/other_user}","gists_url":"https://api.github.com/users/mattodd/gists{/gist_id}","starred_url":"https://api.github.com/users/mattodd/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mattodd/subscriptions","organizations_url":"https://api.github.com/users/mattodd/orgs","repos_url":"https://api.github.com/users/mattodd/repos","events_url":"https://api.github.com/users/mattodd/events{/privacy}","received_events_url":"https://api.github.com/users/mattodd/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/question","name":"question","color":"cc317c"},{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Series%204","name":"Series 4","color":"8A0829"}],"state":"open","locked":false,"assignee":{"login":"mattodd","id":4386101,"avatar_url":"https://avatars.githubusercontent.com/u/4386101?v=3","gravatar_id":"","url":"https://api.github.com/users/mattodd","html_url":"https://github.com/mattodd","followers_url":"https://api.github.com/users/mattodd/followers","following_url":"https://api.github.com/users/mattodd/following{/other_user}","gists_url":"https://api.github.com/users/mattodd/gists{/gist_id}","starred_url":"https://api.github.com/users/mattodd/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mattodd/subscriptions","organizations_url":"https://api.github.com/users/mattodd/orgs","repos_url":"https://api.github.com/users/mattodd/repos","events_url":"https://api.github.com/users/mattodd/events{/privacy}","received_events_url":"https://api.github.com/users/mattodd/received_events","type":"User","site_admin":false},"milestone":null,"comments":10,"created_at":"2016-04-13T00:22:54Z","updated_at":"2016-04-28T11:48:00Z","closed_at":null,"body":"I was speaking with Craig Williams at UQ yesterday about his [lovely cubane work](http://onlinelibrary.wiley.com/doi/10.1002/anie.201510675/abstract), which largely validates cubane as a bioisostere of phenyl, and one with potentially lower metabolic liability. Surely we could incorporate this in the side chains of Series 4, given that we might be able to obtain derivatised cubane (e.g. the carboxylic acid) from CSIRO here in Aus.\r\n\r\nOne could imagine a number of ways of doing this, e.g. the most obvious\r\n\r\n![cubane possib](https://cloud.githubusercontent.com/assets/4386101/14479409/7b1a4d8c-0161-11e6-8f62-504006c1acf2.jpg)\r\n\r\nBut there may be others. The replacement certainly helps with deplanarisation. What say you all?\r\n"},"comment":{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/comments/215399624","html_url":"https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/379#issuecomment-215399624","issue_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/379","id":215399624,"user":{"login":"drc007","id":7080516,"avatar_url":"https://avatars.githubusercontent.com/u/7080516?v=3","gravatar_id":"","url":"https://api.github.com/users/drc007","html_url":"https://github.com/drc007","followers_url":"https://api.github.com/users/drc007/followers","following_url":"https://api.github.com/users/drc007/following{/other_user}","gists_url":"https://api.github.com/users/drc007/gists{/gist_id}","starred_url":"https://api.github.com/users/drc007/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/drc007/subscriptions","organizations_url":"https://api.github.com/users/drc007/orgs","repos_url":"https://api.github.com/users/drc007/repos","events_url":"https://api.github.com/users/drc007/events{/privacy}","received_events_url":"https://api.github.com/users/drc007/received_events","type":"User","site_admin":false},"created_at":"2016-04-28T11:48:00Z","updated_at":"2016-04-28T11:48:00Z","body":"One of the features of the two aryl systems is that there is the possibility of hydrophobic collapse with the two aryl rings pi-stacking (this was seen in the NMR). It would be interesting to see how the proposed cubane behaves."}}