{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12294","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12294/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12294/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12294/events","html_url":"https://github.com/geneontology/go-ontology/issues/12294","id":134255871,"number":12294,"title":"GO:0043148 mitotic spindle stabilization","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"milestone":null,"comments":4,"created_at":"2016-02-17T11:35:14Z","updated_at":"2016-02-22T18:52:18Z","closed_at":null,"body":"\r\nI have a problem with this term\r\nhttp://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0043148#term=annotation\r\nThe cell cycle process in which spindle integrity is maintained during M phase of mitosis.\r\n\r\nI don't think we are really annotating 'stability' here, its used as a catch  all for phenotypes like \r\n\"spindle collapse' when things go wrong with the spindle assembly or elongation. One problem with this term is that it links to 'regulation'.\r\n\r\nPerhaps the solution would be to merge it with\r\nGO:0007052 mitotic spindle organization\r\nA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.\r\n\r\n\r\nI don't see a difference? (I probably requested this term years ago...)\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/187316330","html_url":"https://github.com/geneontology/go-ontology/issues/12294#issuecomment-187316330","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12294","id":187316330,"user":{"login":"robnash","id":12737663,"avatar_url":"https://avatars.githubusercontent.com/u/12737663?v=3","gravatar_id":"","url":"https://api.github.com/users/robnash","html_url":"https://github.com/robnash","followers_url":"https://api.github.com/users/robnash/followers","following_url":"https://api.github.com/users/robnash/following{/other_user}","gists_url":"https://api.github.com/users/robnash/gists{/gist_id}","starred_url":"https://api.github.com/users/robnash/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/robnash/subscriptions","organizations_url":"https://api.github.com/users/robnash/orgs","repos_url":"https://api.github.com/users/robnash/repos","events_url":"https://api.github.com/users/robnash/events{/privacy}","received_events_url":"https://api.github.com/users/robnash/received_events","type":"User","site_admin":false},"created_at":"2016-02-22T18:52:18Z","updated_at":"2016-02-22T18:52:18Z","body":"Hi,\r\n\r\nI had a quick look at the terms and the annotations at SGD. I have also read the thread. I think Val has a reasonable argument here, as the two terms appear to be very similar, and in reality spindle stabilization is just a downstream consequence of a properly assembled spindle. With respect to our annotations Ase1 is clearly involved in assembly and elongation of the spindle so I think we could re-annotate to the assembly term with no loss in information. For Fin1p, we will need to work on the annotations as its been shown to be a PP1 regulatory subunit and very recently demonstrated to be involved in recovery from the spindle assembly checkpoint (SAC) by kicking the checkpoint protein Bub1p off of the kinetochore in anaphase as part of recovery from SAC. The original annotations as Val argues are probably just a consequence of the premature localization of the mutant protein to the spindle, resulting in spindle instability ... a phenotype. \r\n\r\nHope this helps.\r\n\r\nCheers,\r\nRob\r\n"}}