{"action":"created","issue":{"url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology/issues/925","repository_url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology","labels_url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology/issues/925/labels{/name}","comments_url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology/issues/925/comments","events_url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology/issues/925/events","html_url":"https://github.com/obophenotype/human-phenotype-ontology/issues/925","id":161409353,"number":925,"title":"IgA nephropathy disease definition","user":{"login":"dgale25","id":18548652,"avatar_url":"https://avatars.githubusercontent.com/u/18548652?v=3","gravatar_id":"","url":"https://api.github.com/users/dgale25","html_url":"https://github.com/dgale25","followers_url":"https://api.github.com/users/dgale25/followers","following_url":"https://api.github.com/users/dgale25/following{/other_user}","gists_url":"https://api.github.com/users/dgale25/gists{/gist_id}","starred_url":"https://api.github.com/users/dgale25/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dgale25/subscriptions","organizations_url":"https://api.github.com/users/dgale25/orgs","repos_url":"https://api.github.com/users/dgale25/repos","events_url":"https://api.github.com/users/dgale25/events{/privacy}","received_events_url":"https://api.github.com/users/dgale25/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":1,"created_at":"2016-06-21T11:12:10Z","updated_at":"2016-08-06T23:04:48Z","closed_at":null,"body":"Diagnostic phenotype: IgA two orders of magnitude (ie ++) greater than IgM and IgG (eg IgG +, IgA +++, IgM +) deposited in glomerulus in immunofluorescence, combined with mesangial proliferation.\r\n\r\nOther phenotypic features:\r\nMicroscopic hematuria\r\nMacroscopic hematuria\r\nProteinuria\r\nRenal impairment (CKD or AKI)\r\n\r\nC3 deposition\r\nSubendothelial dense deposits on Electron Microscopy\r\nMesangial dense deposits on EM\r\nOther features correlated with disease activity/stage: Extracapillary glomerular hypercellularity, endocapillary hypercellularity, glomerulosclerosis,  Tubulointerstitial scarring etc.\r\n"},"comment":{"url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology/issues/comments/238053572","html_url":"https://github.com/obophenotype/human-phenotype-ontology/issues/925#issuecomment-238053572","issue_url":"https://api.github.com/repos/obophenotype/human-phenotype-ontology/issues/925","id":238053572,"user":{"login":"pnrobinson","id":4943420,"avatar_url":"https://avatars.githubusercontent.com/u/4943420?v=3","gravatar_id":"","url":"https://api.github.com/users/pnrobinson","html_url":"https://github.com/pnrobinson","followers_url":"https://api.github.com/users/pnrobinson/followers","following_url":"https://api.github.com/users/pnrobinson/following{/other_user}","gists_url":"https://api.github.com/users/pnrobinson/gists{/gist_id}","starred_url":"https://api.github.com/users/pnrobinson/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pnrobinson/subscriptions","organizations_url":"https://api.github.com/users/pnrobinson/orgs","repos_url":"https://api.github.com/users/pnrobinson/repos","events_url":"https://api.github.com/users/pnrobinson/events{/privacy}","received_events_url":"https://api.github.com/users/pnrobinson/received_events","type":"User","site_admin":false},"created_at":"2016-08-06T23:04:48Z","updated_at":"2016-08-06T23:04:48Z","body":"Note HP:0004746, dense deposit disease, should be altered the phenotype of dense deposits on EM. Need to read the original literature."}}
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