{"action":"created","issue":{"url":"https://api.github.com/repos/stnava/ANTs/issues/314","repository_url":"https://api.github.com/repos/stnava/ANTs","labels_url":"https://api.github.com/repos/stnava/ANTs/issues/314/labels{/name}","comments_url":"https://api.github.com/repos/stnava/ANTs/issues/314/comments","events_url":"https://api.github.com/repos/stnava/ANTs/issues/314/events","html_url":"https://github.com/stnava/ANTs/issues/314","id":151710479,"number":314,"title":"AverageImages Laplacian sharpening reference","user":{"login":"jmtyszka","id":4984927,"avatar_url":"https://avatars.githubusercontent.com/u/4984927?v=3","gravatar_id":"","url":"https://api.github.com/users/jmtyszka","html_url":"https://github.com/jmtyszka","followers_url":"https://api.github.com/users/jmtyszka/followers","following_url":"https://api.github.com/users/jmtyszka/following{/other_user}","gists_url":"https://api.github.com/users/jmtyszka/gists{/gist_id}","starred_url":"https://api.github.com/users/jmtyszka/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jmtyszka/subscriptions","organizations_url":"https://api.github.com/users/jmtyszka/orgs","repos_url":"https://api.github.com/users/jmtyszka/repos","events_url":"https://api.github.com/users/jmtyszka/events{/privacy}","received_events_url":"https://api.github.com/users/jmtyszka/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":5,"created_at":"2016-04-28T18:23:20Z","updated_at":"2016-04-28T20:21:47Z","closed_at":null,"body":"We have a manuscript in revision where we used ANTs to generate a multivariate template for an atlas. We went with the AverageImages normalization flag = True in the template construction script, so the final templates are mean normalized and Laplacian edge enhanced. We'll need to justify going with this normalization in the manuscript.\r\n\r\nIntuitively, it makes sense to edge enhance the template in order to emphasize boundaries in the optimization, but I'm having trouble finding any references to cite on this. Did the ANTs team ever publish this approach? Also, do you know the weight for the Laplacian filtered image used by ITK (sharpened image = original image + weight * Laplacian filtered image)? \r\n\r\nGreat fan of ANTs BTW! Using it almost exclusively for mid-space and group template generation."},"comment":{"url":"https://api.github.com/repos/stnava/ANTs/issues/comments/215550593","html_url":"https://github.com/stnava/ANTs/issues/314#issuecomment-215550593","issue_url":"https://api.github.com/repos/stnava/ANTs/issues/314","id":215550593,"user":{"login":"jmtyszka","id":4984927,"avatar_url":"https://avatars.githubusercontent.com/u/4984927?v=3","gravatar_id":"","url":"https://api.github.com/users/jmtyszka","html_url":"https://github.com/jmtyszka","followers_url":"https://api.github.com/users/jmtyszka/followers","following_url":"https://api.github.com/users/jmtyszka/following{/other_user}","gists_url":"https://api.github.com/users/jmtyszka/gists{/gist_id}","starred_url":"https://api.github.com/users/jmtyszka/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jmtyszka/subscriptions","organizations_url":"https://api.github.com/users/jmtyszka/orgs","repos_url":"https://api.github.com/users/jmtyszka/repos","events_url":"https://api.github.com/users/jmtyszka/events{/privacy}","received_events_url":"https://api.github.com/users/jmtyszka/received_events","type":"User","site_admin":false},"created_at":"2016-04-28T20:21:47Z","updated_at":"2016-04-28T20:21:47Z","body":"Thanks for clarifying - this all makes a lot more sense, particularly with the background from the hippocampus paper, which we'll definitely be citing in the revision. Thanks again for the quick responses!"}}