{"action":"created","issue":{"url":"https://api.github.com/repos/pombase/curation/issues/947","repository_url":"https://api.github.com/repos/pombase/curation","labels_url":"https://api.github.com/repos/pombase/curation/issues/947/labels{/name}","comments_url":"https://api.github.com/repos/pombase/curation/issues/947/comments","events_url":"https://api.github.com/repos/pombase/curation/issues/947/events","html_url":"https://github.com/pombase/curation/issues/947","id":159917736,"number":947,"title":"rqh1 term diff?","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"mah11","id":5196259,"avatar_url":"https://avatars.githubusercontent.com/u/5196259?v=3","gravatar_id":"","url":"https://api.github.com/users/mah11","html_url":"https://github.com/mah11","followers_url":"https://api.github.com/users/mah11/followers","following_url":"https://api.github.com/users/mah11/following{/other_user}","gists_url":"https://api.github.com/users/mah11/gists{/gist_id}","starred_url":"https://api.github.com/users/mah11/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mah11/subscriptions","organizations_url":"https://api.github.com/users/mah11/orgs","repos_url":"https://api.github.com/users/mah11/repos","events_url":"https://api.github.com/users/mah11/events{/privacy}","received_events_url":"https://api.github.com/users/mah11/received_events","type":"User","site_admin":false},"milestone":null,"comments":2,"created_at":"2016-06-13T10:21:02Z","updated_at":"2016-06-13T11:41:50Z","closed_at":null,"body":"\r\n\r\nI was looking at rqh1 for the paper I am curating where it is functionally linked to cut8  (out of my comfort zone)\r\n\r\nI spotted\r\nGO:1903221\tregulation of mitotic recombination involved in replication fork processing\tIMP\t\tIraqui I et al. (2012)\t\r\n\r\nbut other genes have\r\nGO:1990426\thomologous recombination-dependent replication fork processing\r\n\r\nmaybe  GO:1990426 is a better term to use?\r\n\r\nIs there a difference between\r\nrecombination-dependent replication fork processing\r\nand\r\nrecombination involved in replication fork processing\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/pombase/curation/issues/comments/225557937","html_url":"https://github.com/pombase/curation/issues/947#issuecomment-225557937","issue_url":"https://api.github.com/repos/pombase/curation/issues/947","id":225557937,"user":{"login":"mah11","id":5196259,"avatar_url":"https://avatars.githubusercontent.com/u/5196259?v=3","gravatar_id":"","url":"https://api.github.com/users/mah11","html_url":"https://github.com/mah11","followers_url":"https://api.github.com/users/mah11/followers","following_url":"https://api.github.com/users/mah11/following{/other_user}","gists_url":"https://api.github.com/users/mah11/gists{/gist_id}","starred_url":"https://api.github.com/users/mah11/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mah11/subscriptions","organizations_url":"https://api.github.com/users/mah11/orgs","repos_url":"https://api.github.com/users/mah11/repos","events_url":"https://api.github.com/users/mah11/events{/privacy}","received_events_url":"https://api.github.com/users/mah11/received_events","type":"User","site_admin":false},"created_at":"2016-06-13T11:41:50Z","updated_at":"2016-06-13T11:41:50Z","body":"The GO:1903221 and GO:1990426 annotations come from papers Sarah Lambert curated (coincidentally, the same papers that came up wrt your question about DNA replication annotations a week or two ago); as I mentioned, I did the session approvals but had to trust that Sarah picked sensible GO BP terms because I don't know this area particularly well. It looks like I added terms in TG based on her comments. The two terms used for rqh1 come from different papers, with different evidence, so that may well account for why different terms are used (I can reread the papers to confirm if it's important).\r\n\r\nPMID:23093942 (40fd88a127db667a)\r\nPMID:25313826 (e8a53aa5aa4d49f7)\r\n\r\nI haven't really done much annotation for rqh1 myself (mostly phenotypes as they've come up in papers on tangentially related topics). I do not know the precise role of rqh1 in fork processing, so I don't know whether \"resolution of (mitotic) recombination intermediates involved in replication fork processing\" is applicable. How high a priority is it to investigate further?\r\n\r\nAs for the existing terms, it looks like GO:1903221 should be part_of GO:1903211 and the names might as well match. I'll open a GO ticket for that.\r\n\r\nre ISO: The unwinding annotation could probably be moved up to 'DNA duplex unwinding' GO:0032508 for both the S. cerevisiae SGS1 IDA and the inferred pombe annotation -- SGD's annotation dates back to 2002, when GO:0006268 was named 'DNA unwinding'. The cited paper unequivocally supports annotation to unwinding but doesn't address whether the context is replication, repair or something else."}}
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