{"action":"opened","issue":{"url":"https://api.github.com/repos/NCBI-Hackathons/Graph_Genomes_CSHL/issues/11","repository_url":"https://api.github.com/repos/NCBI-Hackathons/Graph_Genomes_CSHL","labels_url":"https://api.github.com/repos/NCBI-Hackathons/Graph_Genomes_CSHL/issues/11/labels{/name}","comments_url":"https://api.github.com/repos/NCBI-Hackathons/Graph_Genomes_CSHL/issues/11/comments","events_url":"https://api.github.com/repos/NCBI-Hackathons/Graph_Genomes_CSHL/issues/11/events","html_url":"https://github.com/NCBI-Hackathons/Graph_Genomes_CSHL/issues/11","id":185552495,"number":11,"title":"CSHL graph genome talk","user":{"login":"evanbiederstedt","id":6968193,"avatar_url":"https://avatars.githubusercontent.com/u/6968193?v=3","gravatar_id":"","url":"https://api.github.com/users/evanbiederstedt","html_url":"https://github.com/evanbiederstedt","followers_url":"https://api.github.com/users/evanbiederstedt/followers","following_url":"https://api.github.com/users/evanbiederstedt/following{/other_user}","gists_url":"https://api.github.com/users/evanbiederstedt/gists{/gist_id}","starred_url":"https://api.github.com/users/evanbiederstedt/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/evanbiederstedt/subscriptions","organizations_url":"https://api.github.com/users/evanbiederstedt/orgs","repos_url":"https://api.github.com/users/evanbiederstedt/repos","events_url":"https://api.github.com/users/evanbiederstedt/events{/privacy}","received_events_url":"https://api.github.com/users/evanbiederstedt/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2016-10-27T01:36:31Z","updated_at":"2016-10-27T01:36:31Z","closed_at":null,"body":"Just heard talk by Jacob Pritt (student with Steven Salzberg and Ben Langmead at JHU) about their attempt at a graph genome. Other hackathon members were around as well, i.e. @nhansen @nathandunn @DCGenomics)\r\n\r\nDiscussed some challenges they were trying to tackle with regards to constructing a graph genome (e.g. should we treat all variants as equally relevant? If treated the same, what bias are we introducing?)\r\n\r\nIntroduced hisat2: https://github.com/infphilo/hisat2, with this background: http://www.nature.com/nature/journal/v526/n7571/full/nature15393.html\r\n\r\nTheir project could benefit from ours (or at least, there's collaboration to be made here). They're naturally having issues with scaling. We could definite us their benchmarks for our own paper.\r\n\r\nWhat details do you have to add, @DCGenomics? @nhansen? @nathandunn ?"}}
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